hydrocortisone probutate 🐶 Veterinary Use | Indications/Contra | FAERs-F | FAERs-M | Orange Bk | BioActivity |

Stem definition	Drug id	CAS RN
corticosteroids, except prednisolone derivatives	4569	72590-77-3

Description:

Molecule

Description

Molfile Inchi Smiles

Synonyms:

hydrocortisone buteprate
hydrocortisone probutate
pandel

Molecular weight: 488.62
Formula: C28H40O7
CLOGP: 4.55
LIPINSKI: 0
HAC: 7
HDO: 1
TPSA: 106.97
ALOGS: -5.24
ROTB: 9

Status: OFP

Legend:
OFP - off patent
OFM - off market
ONP - on patent

Drug dosage:

None

ADMET properties:

Property	Value	Reference
S (Water solubility)	0.23 mg/mL	Bocci G, Oprea TI, Benet LZ

Approvals:

Date	Agency	Company	Orphan
Feb. 28, 1997	FDA	FOUGERA PHARMS

FDA Adverse Event Reporting System (Female)

MedDRA adverse event term	Likelihood ratio	Likelihood ratio threshold	Patients taking drug having adverse event	Patients taking drug not having adverse event	Patients not taking drug having adverse event	Patients not taking drug not having adverse event
C-reactive protein	55.22	36.82	15	1817	4867	63482323
Deep vein thrombosis postoperative	46.59	36.82	16	1816	11353	63475837
Lip dry	41.78	36.82	16	1816	15454	63471736
Autoimmune disorder	40.15	36.82	16	1816	17161	63470029

FDA Adverse Event Reporting System (Male)

None

FDA Adverse Event Reporting System (Geriatric)

MedDRA adverse event term	Likelihood ratio	Likelihood ratio threshold	Patients taking drug having adverse event	Patients taking drug not having adverse event	Patients not taking drug having adverse event	Patients not taking drug not having adverse event
C-reactive protein	58.29	50.19	15	1820	4964	79737589
Deep vein thrombosis postoperative	51.02	50.19	16	1819	10736	79731817

FDA Adverse Event Reporting System (Pediatric)

None

Pharmacologic Action:

Source	Code	Description
ATC	D07AB11	DERMATOLOGICALS CORTICOSTEROIDS, DERMATOLOGICAL PREPARATIONS CORTICOSTEROIDS, PLAIN Corticosteroids, moderately potent (group II)
FDA MoA	N0000175450	Corticosteroid Hormone Receptor Agonists
FDA EPC	N0000175576	Corticosteroid
MeSH PA	D000893	Anti-Inflammatory Agents
CHEBI has role	CHEBI:35472	anti-inflammatory drugs
CHEBI has role	CHEBI:49167	anti-asthmatic drugs
CHEBI has role	CHEBI:50857	anti-allergic drugs
CHEBI has role	CHEBI:75771	Mus musculus metabolites
CHEBI has role	CHEBI:77746	Homo sapiens metabolite
CHEBI has role	CHEBI:88188	allergenic drug

Drug Use | Suggest Off label Use Form| |View source of the data|

None

🐶 Veterinary Drug Use

None

🐶 Veterinary products

None

Acid dissociation constants calculated using MoKa v3.0.0

None

Orange Book patent data (new drug applications)

None

Orange Book exclusivity data (new drug applications)

None

Bioactivity Summary:

Target	Class	Pharos	UniProt	Action	Type	Activity value (-log[M])	Mechanism action	Bioact source	MoA source
Glucocorticoid receptor	Nuclear hormone receptor	P04150	GCR_HUMAN	AGONIST				CHEMBL	CHEMBL

External reference:

ID	Source
4025074	VUID
N0000179153	NUI
4017941	VANDF
4021000	VANDF
4025074	VANDF
CHEBI:31675	CHEBI
CHEBI:17650	CHEBI
CHEMBL1200953	ChEMBL_ID
C033014	MESH_SUPPLEMENTAL_RECORD_UI
DB14543	DRUGBANK_ID
O6550D6K3A	UNII
DB00741	DRUGBANK_ID
219083	RXNORM
17268	MMSL
2500	MMSL
4837	MMSL
4839	MMSL
9839	MMSL
d00254	MMSL
002147	NDDF
006405	NDDF
126150008	SNOMEDCT_US
16602005	SNOMEDCT_US
396458002	SNOMEDCT_US
C0063076	UMLSCUI
C0020268	UMLSCUI
636398	PUBCHEM_CID
38	INN_ID
5754	PUBCHEM_CID
D006854	MESH_DESCRIPTOR_UI

Pharmaceutical products:

Product	Category	Ingredients	NDC	Form	Quantity	Route	Marketing	Label
PANDEL	HUMAN PRESCRIPTION DRUG LABEL	1	10337-153	CREAM	1 mg	TOPICAL	NDA	22 sections
PANDEL	HUMAN PRESCRIPTION DRUG LABEL	1	62559-325	CREAM	1 mg	TOPICAL	NDA	22 sections