samarium (153Sm) lexidronam 🐶 Veterinary Use | Indications/Contra | FAERs-F | FAERs-M | Orange Bk | BioActivity |

Stem definitionDrug idCAS RN
4533 160369-78-8

Description:

MoleculeDescription

Synonyms:

  • samarium [153Sm] lexidronam pentasodium
  • Samarium Sm 153 lexidronam pentasodium
  • samarium (153Sm) lexidronam
  • quadramet
  • samarium SM-153 lexidronam pentasodium
  • Molecular weight: 695.93
  • Formula: C6H12N2Na5O12P4Sm
  • CLOGP:
  • LIPINSKI: None
  • HAC: None
  • HDO: None
  • TPSA:
  • ALOGS:
  • ROTB: None

Drug dosage:

None

ADMET properties:

None

Approvals:

DateAgencyCompanyOrphan
Feb. 5, 1998 EMA
March 28, 1997 FDA LANTHEUS MEDICAL

FDA Adverse Event Reporting System (Female)

None

FDA Adverse Event Reporting System (Male)

None

FDA Adverse Event Reporting System (Geriatric)

None

FDA Adverse Event Reporting System (Pediatric)

None

Pharmacologic Action:

SourceCodeDescription
ATC V10BX02 VARIOUS
THERAPEUTIC RADIOPHARMACEUTICALS
PAIN PALLIATION (BONE SEEKING AGENTS)
Various pain palliation radiopharmaceuticals
FDA MoA N0000000205 Radiopharmaceutical Activity
MeSH PA D000700 Analgesics
MeSH PA D018712 Analgesics, Non-Narcotic
MeSH PA D002491 Central Nervous System Agents
MeSH PA D018373 Peripheral Nervous System Agents
MeSH PA D018689 Sensory System Agents
FDA EPC N0000175872 Radioactive Therapeutic Agent

Drug Use | Suggest Off label Use Form| |View source of the data|

DiseaseRelationSNOMED_IDDOID
Pain due to Osteoblastic Bone Metastasis indication
Chronic heart failure contraindication 48447003
Kidney disease contraindication 90708001 DOID:557
Secondary malignant neoplasm of bone marrow contraindication 94217008
Pregnancy, function contraindication 289908002
Thrombocytopenic disorder contraindication 302215000 DOID:1588
Neutropenic disorder contraindication 303011007 DOID:1227
Bone marrow depression contraindication 307762000
Breastfeeding (mother) contraindication 413712001




🐶 Veterinary Drug Use

None

🐶 Veterinary products

None

Acid dissociation constants calculated using MoKa v3.0.0

None

Orange Book patent data (new drug applications)

None

Orange Book exclusivity data (new drug applications)

None

Bioactivity Summary:

None

External reference:

IDSource
176669-18-4 SECONDARY_CAS_RN
CHEMBL2096660 ChEMBL_ID
C061972 MESH_SUPPLEMENTAL_RECORD_UI
DB05273 DRUGBANK_ID
118987134 PUBCHEM_CID
177906 RXNORM
21654 MMSL
83197 MMSL
d04531 MMSL
006717 NDDF
006718 NDDF
1173066007 SNOMEDCT_US
125699003 SNOMEDCT_US
420098005 SNOMEDCT_US
C0772051 UMLSCUI
7389YR3OOV UNII

Pharmaceutical products:

ProductCategoryIngredientsNDCFormQuantityRouteMarketingLabel
Quadramet HUMAN PRESCRIPTION DRUG LABEL 1 11994-016 INJECTION, SOLUTION 50 mCi INTRAVENOUS NDA 22 sections