ferrous sulfate ๐Ÿถ Veterinary Use | Indications/Contra | FAERs-F | FAERs-M | Orange Bk | BioActivity |

Stem definitionDrug idCAS RN
4528 7720-78-7

Description:

MoleculeDescription

Synonyms:

  • ferrous sulfate
  • ferrous sulfate, dried
Ferro-Gradumet is ferrous sulfate in controlled release form; RN given refers to Fe(+2)[1:1] salt
  • Molecular weight: 151.90
  • Formula: FeO4S
  • CLOGP:
  • LIPINSKI: None
  • HAC: None
  • HDO: None
  • TPSA: 80.26
  • ALOGS:
  • ROTB: None

Drug dosage:

DoseUnitRoute
0.20 g O

ADMET properties:

PropertyValueReference
BDDCS (Biopharmaceutical Drug Disposition Classification System) 3 Benet LZ, Broccatelli F, Oprea TI
S (Water solubility) 570 mg/mL Benet LZ, Broccatelli F, Oprea TI
MRTD (Maximum Recommended Therapeutic Daily Dose) 30.56 ยตM/kg/day Contrera JF, Matthews EJ, Kruhlak NL, Benz RD

Approvals:

DateAgencyCompanyOrphan
Aug. 13, 1946 FDA LEDERLE

FDA Adverse Event Reporting System (Female)

MedDRA adverse event termLikelihood ratioLikelihood ratio thresholdPatients taking drug having adverse eventPatients taking drug not having adverse eventPatients not taking drug having adverse eventPatients not taking drug not having adverse event
Drug ineffective 184.81 10.23 254 42400 819079 49743391
Acute kidney injury 130.95 10.23 456 42198 227602 50334868
Anaemia 114.42 10.23 468 42186 251988 50310482
Drug intolerance 85.28 10.23 39 42615 219065 50343405
Hypervolaemia 81.55 10.23 104 42550 25395 50537075
Contraindicated product administered 80.99 10.23 14 42640 148944 50413526
Treatment failure 76.91 10.23 12 42642 137625 50424845
Hand deformity 71.52 10.23 3 42651 100196 50462274
Completed suicide 70.38 10.23 13 42641 131876 50430594
Haemoglobin decreased 69.09 10.23 250 42404 126966 50435504
Systemic lupus erythematosus 68.64 10.23 17 42637 140605 50421865
Glossodynia 64.74 10.23 10 42644 115559 50446911
Rheumatoid arthritis 58.27 10.23 51 42603 202499 50359971
Hepatic enzyme increased 57.36 10.23 22 42632 137358 50425112
Joint swelling 52.91 10.23 78 42576 245208 50317262
Pulmonary malformation 51.99 10.23 15 42639 192 50562278
Arthropathy 51.46 10.23 35 42619 157871 50404599
Gastrointestinal haemorrhage 48.51 10.23 154 42500 73167 50489303
Alopecia 48.06 10.23 83 42571 244964 50317506
Discomfort 47.54 10.23 16 42638 108364 50454106
Pulmonary hypertension 47.50 10.23 94 42560 33323 50529147
Melaena 47.50 10.23 83 42571 26781 50535689
Therapeutic product effect decreased 47.29 10.23 28 42626 136022 50426448
Pulmonary arterial hypertension 45.71 10.23 70 42584 20249 50542221
Drug hypersensitivity 45.68 10.23 89 42565 250921 50311549
Premature delivery 45.65 10.23 76 42578 23587 50538883
Pericarditis 43.63 10.23 7 42647 78682 50483788
Hyperkalaemia 41.41 10.23 111 42543 47978 50514492
Hospitalisation 40.73 10.23 138 42516 67799 50494671
Cardiac failure acute 38.71 10.23 41 42613 8209 50554261
Lung cyst 36.64 10.23 11 42643 163 50562307
Iron deficiency anaemia 36.47 10.23 57 42597 16777 50545693
Wound 36.44 10.23 22 42632 105772 50456698
Abdominal discomfort 35.68 10.23 90 42564 231551 50330919
Right ventricular failure 34.69 10.23 54 42600 15839 50546631
Metabolic alkalosis 34.57 10.23 24 42630 2707 50559763
Hypoxia 34.37 10.23 108 42546 51015 50511455
Hypersensitivity 32.82 10.23 84 42570 215077 50347393
Arthralgia 32.75 10.23 226 42428 438476 50123994
Transfusion 32.68 10.23 47 42607 12858 50549612
Congenital ovarian anomaly 32.32 10.23 6 42648 6 50562464
Musculoskeletal stiffness 31.62 10.23 37 42617 128444 50434026
Helicobacter infection 31.00 10.23 3 42651 49699 50512771
Infusion related reaction 30.92 10.23 60 42594 169497 50392973
Pain 30.78 10.23 326 42328 578577 49983893
Pneumonia 30.66 10.23 468 42186 377933 50184537
Acute respiratory failure 30.61 10.23 72 42582 28710 50533760
Urinary tract infection 30.23 10.23 305 42349 223715 50338755
Faeces discoloured 30.05 10.23 51 42603 16073 50546397
Transferrin saturation increased 29.88 10.23 7 42647 36 50562434
Metabolic acidosis 29.85 10.23 86 42568 38739 50523731
Autoimmune haemolytic anaemia 28.47 10.23 25 42629 3974 50558496
Congenital skin dimples 26.94 10.23 8 42646 114 50562356
Gastrointestinal tract mucosal pigmentation 26.82 10.23 12 42642 572 50561898
Cardiac failure congestive 26.67 10.23 141 42513 84241 50478229
Foetal exposure during pregnancy 26.48 10.23 66 42588 27293 50535177
Transferrin increased 26.46 10.23 5 42649 6 50562464
Death 25.79 10.23 401 42253 324978 50237492
Lactic acidosis 24.79 10.23 73 42581 33282 50529188
Dyspnoea exertional 24.72 10.23 97 42557 51136 50511334
Toxicity to various agents 24.59 10.23 94 42560 212405 50350065
Respiratory tract malformation 24.23 10.23 7 42647 90 50562380
Product use issue 23.84 10.23 57 42597 149418 50413052
Dyspnoea 23.35 10.23 615 42039 546993 50015477
Hypotension 22.95 10.23 301 42353 235168 50327302
Fluid retention 22.92 10.23 94 42560 50555 50511915
Maternal exposure during breast feeding 22.48 10.23 20 42634 3234 50559236
Exposure via breast milk 22.42 10.23 15 42639 1593 50560877
Impaired healing 22.01 10.23 16 42638 69770 50492700
Gingival hypertrophy 21.94 10.23 14 42640 1372 50561098
Blood loss anaemia 21.13 10.23 30 42624 8109 50554361
Therapeutic product effect incomplete 20.79 10.23 28 42626 91487 50470983
General physical health deterioration 20.64 10.23 57 42597 142377 50420093
Folliculitis 20.62 10.23 4 42650 39221 50523249
Oesophageal injury 20.42 10.23 5 42649 32 50562438
Haemoptysis 20.00 10.23 57 42597 25516 50536954
Pre-eclampsia 19.93 10.23 29 42625 8015 50554455
Hypoosmolar state 19.86 10.23 7 42647 176 50562294
Hypothermia 19.79 10.23 36 42618 11980 50550490
Diastasis recti abdominis 19.79 10.23 5 42649 37 50562433
Fall 19.46 10.23 393 42261 334539 50227931
Blood iron decreased 19.39 10.23 35 42619 11580 50550890
Hypoglycaemia 19.37 10.23 93 42561 53488 50508982
Hepatic encephalopathy 18.65 10.23 31 42623 9605 50552865
Diarrhoea 18.61 10.23 637 42017 587839 49974631
Sight disability 18.50 10.23 6 42648 116 50562354
Thermohypoaesthesia 18.45 10.23 6 42648 117 50562353
Renal arteriosclerosis 18.36 10.23 5 42649 51 50562419
Foetal death 18.14 10.23 28 42626 8152 50554318
Glucocorticoids increased 18.04 10.23 6 42648 126 50562344
Mobility decreased 17.62 10.23 25 42629 79923 50482547
Drug abuse 17.27 10.23 15 42639 59831 50502639
Asthenia 17.11 10.23 370 42284 318672 50243798
Cellulitis 16.98 10.23 110 42544 70688 50491782
Sepsis 16.96 10.23 179 42475 132746 50429724
Discharge 16.96 10.23 10 42644 851 50561619
Haemorrhagic erosive gastritis 16.92 10.23 7 42647 275 50562195
Haematochezia 16.47 10.23 72 42582 39810 50522660
Cardiac failure 16.35 10.23 115 42539 75925 50486545
Epistaxis 16.35 10.23 101 42553 63853 50498617
Sopor 16.22 10.23 45 42609 19834 50542636
Hypokalaemia 16.05 10.23 128 42526 87864 50474606
Renal tubular acidosis 16.03 10.23 12 42642 1522 50560948
Hyponatraemia 16.01 10.23 137 42517 96002 50466468
Chronic obstructive pulmonary disease 16.00 10.23 88 42566 53347 50509123
Chronic kidney disease 15.82 10.23 71 42583 39700 50522770
Lactation disorder 15.78 10.23 7 42647 327 50562143
Internal haemorrhage 15.69 10.23 19 42635 4398 50558072
Foetal malnutrition 15.45 10.23 5 42649 96 50562374
Mental status changes 15.38 10.23 66 42588 36206 50526264
Constipation 15.11 10.23 230 42424 185478 50376992
Haematocrit decreased 15.10 10.23 64 42590 34912 50527558
Infected neoplasm 14.97 10.23 6 42648 217 50562253
Blood creatine phosphokinase MM increased 14.95 10.23 4 42650 38 50562432
N-terminal prohormone brain natriuretic peptide increased 14.88 10.23 12 42642 1698 50560772
Genital prolapse 14.76 10.23 4 42650 40 50562430
Rectal haemorrhage 14.72 10.23 68 42586 38490 50523980
Infective pulmonary exacerbation of cystic fibrosis 14.72 10.23 25 42629 7884 50554586
Respiratory failure 14.70 10.23 129 42525 91052 50471418
Congenital cystic lung 14.58 10.23 4 42650 42 50562428
Troponin increased 14.24 10.23 25 42629 8093 50554377
Hypermagnesaemia 14.08 10.23 9 42645 885 50561585
Sinus node dysfunction 14.03 10.23 17 42637 3938 50558532
Abdominal pain 13.97 10.23 278 42376 235950 50326520
Periodontitis 13.95 10.23 15 42639 3054 50559416
Haematemesis 13.78 10.23 53 42601 27672 50534798
Arteriovenous malformation 13.50 10.23 10 42644 1248 50561222
Therapeutic response decreased 13.43 10.23 12 42642 47219 50515251
Psoriatic arthropathy 13.31 10.23 12 42642 47020 50515450
Urticaria 13.30 10.23 60 42594 129501 50432969
Blister 13.27 10.23 33 42621 85385 50477085
Product dose omission issue 13.19 10.23 223 42431 183615 50378855
Ketosis 12.80 10.23 7 42647 516 50561954
Hypovolaemia 12.70 10.23 26 42628 9439 50553031
Threatened labour 12.58 10.23 8 42646 779 50561691
Maternal condition affecting foetus 12.57 10.23 5 42649 177 50562293
Regressive behaviour 12.40 10.23 4 42650 76 50562394
Rash 12.31 10.23 278 42376 437193 50125277
Azotaemia 12.26 10.23 16 42638 3992 50558478
International normalised ratio increased 12.21 10.23 70 42584 43082 50519388
Abdominal distension 12.19 10.23 104 42550 72799 50489671
Cholestasis 12.17 10.23 48 42606 25353 50537117
Meningism 12.16 10.23 6 42648 357 50562113
Urine output decreased 12.11 10.23 27 42627 10394 50552076
Atrial fibrillation 12.04 10.23 135 42519 101610 50460860
Application site haematoma 11.90 10.23 3 42651 22 50562448
Hospice care 11.75 10.23 19 42635 5753 50556717
C-reactive protein increased 11.69 10.23 24 42630 66450 50496020
Swelling 11.49 10.23 111 42543 200761 50361709
Clostridium difficile colitis 11.48 10.23 37 42617 17705 50544765
Exposure during pregnancy 11.48 10.23 154 42500 120861 50441609
Irritable bowel syndrome 11.42 10.23 16 42638 51425 50511045
Hyponatraemic seizure 11.39 10.23 6 42648 410 50562060
Full blood count decreased 11.34 10.23 43 42611 22303 50540167
Portal hypertensive gastropathy 11.28 10.23 7 42647 653 50561817
Pulmonary oedema 11.10 10.23 75 42579 48863 50513607
Cellulitis orbital 11.10 10.23 6 42648 432 50562038
Haemoglobin abnormal 11.07 10.23 16 42638 4396 50558074
Anastomotic stenosis 11.06 10.23 5 42649 244 50562226
Umbilical discharge 11.01 10.23 4 42650 110 50562360
Syncope 11.00 10.23 134 42520 102868 50459602
Uterine leiomyoma 10.97 10.23 22 42632 7869 50554601
Angina unstable 10.93 10.23 20 42634 6686 50555784
Mixed liver injury 10.91 10.23 14 42640 3437 50559033
Sinus arrest 10.87 10.23 10 42644 1688 50560782
Hepatic cirrhosis 10.78 10.23 36 42618 17541 50544929
Haemoperitoneum 10.77 10.23 12 42642 2543 50559927
Lethargy 10.77 10.23 75 42579 49357 50513113
Optic ischaemic neuropathy 10.73 10.23 8 42646 1009 50561461
Injection site reaction 10.67 10.23 16 42638 50016 50512454
Oedema 10.64 10.23 98 42556 70083 50492387
Oxygen consumption increased 10.64 10.23 14 42640 3522 50558948
Chronic hepatic failure 10.57 10.23 6 42648 475 50561995
Unwanted awareness during anaesthesia 10.42 10.23 5 42649 280 50562190
Total bile acids increased 10.38 10.23 4 42650 130 50562340
Accidental overdose 10.25 10.23 38 42616 19495 50542975

FDA Adverse Event Reporting System (Male)

MedDRA adverse event termLikelihood ratioLikelihood ratio thresholdPatients taking drug having adverse eventPatients taking drug not having adverse eventPatients not taking drug having adverse eventPatients not taking drug not having adverse event
Acute kidney injury 67.58 11.83 391 22422 264876 29286838
Drug ineffective 57.28 11.83 122 22691 363048 29188666
Completed suicide 51.54 11.83 5 22808 90241 29461473
Hyperkalaemia 47.78 11.83 129 22684 61263 29490451
Foetal disorder 47.14 11.83 19 22794 764 29550950
Faeces discoloured 45.82 11.83 54 22759 13297 29538417
Encephalitis toxic 44.28 11.83 14 22799 273 29551441
Foetal exposure during pregnancy 42.67 11.83 86 22727 33781 29517933
Anaemia 40.33 11.83 279 22534 200672 29351042
Periodontitis 39.99 11.83 22 22791 1795 29549919
Neutropenia neonatal 39.75 11.83 16 22797 641 29551073
Lymph node calcification 39.22 11.83 11 22802 139 29551575
Hospitalisation 37.14 11.83 98 22715 45890 29505824
Drug abuse 35.37 11.83 9 22804 79874 29471840
Premature baby 34.91 11.83 54 22759 17226 29534488
Cardiac dysfunction 34.67 11.83 20 22793 1787 29549927
Gastrointestinal haemorrhage 32.15 11.83 134 22679 79399 29472315
Hyperlactacidaemia 29.77 11.83 21 22792 2657 29549057
Asthenia 27.06 11.83 269 22544 214981 29336733
Low birth weight baby 26.53 11.83 29 22784 6579 29545135
Blood loss anaemia 24.28 11.83 29 22784 7237 29544477
Death 23.50 11.83 382 22431 341702 29210012
Gingival hypertrophy 23.16 11.83 15 22798 1650 29550064
Full blood count decreased 23.05 11.83 43 22770 15949 29535765
Febrile neutropenia 22.79 11.83 32 22781 112208 29439506
Toxicity to various agents 22.06 11.83 65 22748 173596 29378118
Fall 22.04 11.83 221 22592 176957 29374757
Haemoglobin decreased 21.39 11.83 150 22663 108225 29443489
Pancreatic duct stenosis 20.32 11.83 7 22806 180 29551534
Pancreatic calcification 20.14 11.83 7 22806 185 29551529
Iron deficiency anaemia 19.56 11.83 29 22784 8913 29542801
Implant site inflammation 19.53 11.83 6 22807 106 29551608
Gastrointestinal angiodysplasia 18.72 11.83 9 22804 554 29551160
Pancreatic mass 18.03 11.83 10 22803 829 29550885
Clostridium difficile infection 18.00 11.83 39 22774 16102 29535612
Transfusion 17.91 11.83 25 22788 7273 29544441
Urinary tract infection 17.86 11.83 106 22707 72248 29479466
Foreign body aspiration 17.39 11.83 6 22807 155 29551559
Cortical visual impairment 16.77 11.83 4 22809 25 29551689
Exposure during pregnancy 16.26 11.83 26 22787 8528 29543186
Hypervolaemia 15.83 11.83 39 22774 17506 29534208
Tubulointerstitial nephritis 15.68 11.83 39 22774 17604 29534110
Gastrointestinal tract mucosal pigmentation 15.45 11.83 7 22806 376 29551338
Feeding intolerance 15.12 11.83 5 22808 113 29551601
Hospice care 14.96 11.83 19 22794 5049 29546665
Dyspnoea 14.92 11.83 343 22470 326389 29225325
Cardiac ventricular disorder 14.84 11.83 6 22807 243 29551471
Pancreatic injury 14.80 11.83 5 22808 121 29551593
Therapeutic product effect incomplete 14.61 11.83 6 22807 39299 29512415
Enterocolitis bacterial 14.35 11.83 6 22807 265 29551449
Pericardial effusion 13.97 11.83 42 22771 21166 29530548
Therapy interrupted 13.94 11.83 24 22789 8362 29543352
Asocial behaviour 13.57 11.83 4 22809 61 29551653
Bronchial obstruction 13.40 11.83 10 22803 1381 29550333
Ventricular septal defect 13.33 11.83 15 22798 3514 29548200
Ludwig angina 13.22 11.83 5 22808 169 29551545
Suicide attempt 13.02 11.83 5 22808 34105 29517609
Flight of ideas 12.88 11.83 6 22807 344 29551370
Crystal urine 12.80 11.83 4 22809 75 29551639
Acute respiratory failure 12.69 11.83 47 22766 26355 29525359
Bronchial disorder 12.67 11.83 9 22804 1152 29550562
Radiation proctitis 12.65 11.83 4 22809 78 29551636
Lip blister 12.53 11.83 7 22806 588 29551126
Bone marrow failure 12.32 11.83 3 22810 27446 29524268

FDA Adverse Event Reporting System (Geriatric)

MedDRA adverse event termLikelihood ratioLikelihood ratio thresholdPatients taking drug having adverse eventPatients taking drug not having adverse eventPatients not taking drug having adverse eventPatients not taking drug not having adverse event
Acute kidney injury 186.19 10.04 820 54519 448420 63994973
Drug ineffective 163.08 10.04 296 55043 839951 63603442
Completed suicide 132.16 10.04 18 55321 224396 64218997
Anaemia 125.91 10.04 649 54690 378031 64065362
Hypervolaemia 94.47 10.04 139 55200 38146 64405247
Hyperkalaemia 84.12 10.04 233 55106 100896 64342497
Drug intolerance 80.99 10.04 30 55309 187962 64255431
Gastrointestinal haemorrhage 80.30 10.04 273 55066 132039 64311354
Haemoglobin decreased 70.77 10.04 343 54996 194720 64248673
Faeces discoloured 68.71 10.04 97 55242 25632 64417761
Toxicity to various agents 61.64 10.04 138 55201 363375 64080018
Hospitalisation 55.48 10.04 166 55173 75041 64368352
Drug abuse 53.92 10.04 23 55316 132351 64311042
Treatment failure 53.13 10.04 17 55322 116799 64326594
Periodontitis 53.11 10.04 37 55302 4122 64439271
Contraindicated product administered 50.28 10.04 15 55324 107814 64335579
Pulmonary arterial hypertension 48.57 10.04 82 55257 25285 64418108
Pulmonary hypertension 46.88 10.04 110 55229 43029 64400364
Transfusion 46.81 10.04 67 55272 17927 64425466
Gingival hypertrophy 46.15 10.04 29 55310 2718 64440675
Joint swelling 45.04 10.04 72 55267 215310 64228083
Drug hypersensitivity 43.87 10.04 86 55253 237729 64205664
Iron deficiency anaemia 43.56 10.04 72 55267 21817 64421576
Hepatic enzyme increased 43.50 10.04 29 55310 129914 64313479
Dyspnoea 42.93 10.04 859 54480 717815 63725578
Pulmonary malformation 42.71 10.04 12 55327 136 64443257
Melaena 42.17 10.04 121 55218 53427 64389966
Gastrointestinal tract mucosal pigmentation 42.09 10.04 19 55320 908 64442485
Encephalitis toxic 38.63 10.04 13 55326 278 64443115
Death 38.39 10.04 604 54735 482101 63961292
Cardiac failure acute 38.39 10.04 58 55281 16286 64427107
Blood loss anaemia 38.02 10.04 53 55286 13839 64429554
Hypoxia 37.87 10.04 163 55176 87986 64355407
Acute respiratory failure 36.61 10.04 110 55229 49824 64393569
Rheumatoid arthritis 34.27 10.04 55 55284 164239 64279154
Fall 34.05 10.04 524 54815 416302 64027091
Musculoskeletal stiffness 33.19 10.04 34 55305 123172 64320221
Arthropathy 33.02 10.04 33 55306 120934 64322459
Haematemesis 33.02 10.04 102 55237 46897 64396496
Therapeutic product effect decreased 32.03 10.04 31 55308 115320 64328073
Metabolic acidosis 31.86 10.04 133 55206 70825 64372568
Urinary tract infection 31.80 10.04 321 55018 231275 64212118
Therapeutic product effect incomplete 30.89 10.04 26 55313 103456 64339937
Systemic lupus erythematosus 30.78 10.04 14 55325 77598 64365795
Arthralgia 30.62 10.04 238 55101 442022 64001371
Lymph node calcification 29.91 10.04 11 55328 308 64443085
Right ventricular failure 29.29 10.04 60 55279 21411 64421982
Alopecia 28.77 10.04 62 55277 165628 64277765
Lung cyst 28.41 10.04 9 55330 158 64443235
Febrile neutropenia 28.02 10.04 76 55263 187581 64255812
Cardiac failure congestive 27.43 10.04 199 55140 130381 64313012
Glossodynia 26.72 10.04 11 55328 64685 64378708
Infusion related reaction 26.56 10.04 64 55275 164403 64278990
Metabolic alkalosis 26.49 10.04 24 55315 3904 64439489
Transferrin saturation increased 26.36 10.04 8 55331 121 64443272
Asthenia 26.24 10.04 514 54825 427530 64015863
Discomfort 25.80 10.04 19 55320 80859 64362534
Hyponatraemia 25.60 10.04 216 55123 148123 64295270
Dyspnoea exertional 25.51 10.04 128 55211 73602 64369791
Fluid retention 25.42 10.04 110 55229 59496 64383897
Pericarditis 25.23 10.04 11 55328 62505 64380888
Foetal death 24.84 10.04 28 55311 5902 64437491
Premature delivery 24.24 10.04 51 55288 18538 64424855
Hypotension 23.17 10.04 457 54882 380517 64062876
Chronic kidney disease 22.53 10.04 104 55235 57815 64385578
Haemoptysis 22.06 10.04 92 55247 48956 64394437
Hypothermia 21.97 10.04 51 55288 19805 64423588
Bone marrow failure 21.76 10.04 7 55332 47945 64395448
Chronic obstructive pulmonary disease 21.59 10.04 119 55220 70929 64372464
Transferrin increased 21.37 10.04 5 55334 25 64443368
Oesophageal injury 21.04 10.04 6 55333 72 64443321
Mental status changes 21.03 10.04 106 55233 61056 64382337
Lactic acidosis 20.81 10.04 106 55233 61304 64382089
Hospice care 20.73 10.04 29 55310 7596 64435797
Tubulointerstitial nephritis 20.71 10.04 66 55273 30843 64412550
Discharge 20.56 10.04 12 55327 984 64442409
Helicobacter infection 20.49 10.04 4 55335 38358 64405035
Pre-eclampsia 20.48 10.04 26 55313 6205 64437188
Cardiac failure 20.37 10.04 188 55151 132185 64311208
Drug resistance 20.20 10.04 3 55336 35099 64408294
Pneumonia 19.87 10.04 624 54715 558952 63884441
Duodenal ulcer perforation 19.84 10.04 3 55336 34622 64408771
Clostridium difficile infection 19.65 10.04 72 55267 36091 64407302
Impaired healing 19.56 10.04 14 55325 60459 64382934
Maternal exposure during breast feeding 19.13 10.04 15 55324 2001 64441392
C-reactive protein increased 18.65 10.04 33 55306 94876 64348517
Flight of ideas 18.58 10.04 10 55329 701 64442692
Off label use 18.53 10.04 408 54931 632398 63810995
Implant site inflammation 18.33 10.04 7 55332 218 64443175
Pancreatic calcification 18.24 10.04 7 55332 221 64443172
Urticaria 18.20 10.04 65 55274 147252 64296141
Glucocorticoids increased 17.93 10.04 6 55333 126 64443267
Pancreatic duct stenosis 17.92 10.04 7 55332 232 64443161
Product dose omission issue 17.88 10.04 250 55089 194497 64248896
Hypoglycaemia 17.73 10.04 135 55204 89757 64353636
Cytomegalovirus infection 17.65 10.04 5 55334 37194 64406199
Iron deficiency 17.61 10.04 26 55313 7151 64436242
Exposure via breast milk 17.55 10.04 10 55329 784 64442609
Hypovolaemia 17.38 10.04 40 55299 15446 64427947
Hypoosmolar state 17.24 10.04 7 55332 257 64443136
Hypokalaemia 17.21 10.04 170 55169 121733 64321660
Drug eruption 16.89 10.04 5 55334 36131 64407262
Cortical visual impairment 16.78 10.04 4 55335 22 64443371
Drug dependence 16.72 10.04 4 55335 33308 64410085
Upper gastrointestinal haemorrhage 16.58 10.04 67 55272 35153 64408240
Pulmonary oedema 16.57 10.04 120 55219 78554 64364839
Diarrhoea 16.16 10.04 766 54573 721938 63721455
Infective pulmonary exacerbation of cystic fibrosis 16.13 10.04 33 55306 11763 64431630
Respiratory failure 16.06 10.04 210 55129 160973 64282420
Gastrointestinal angiodysplasia 16.05 10.04 10 55329 923 64442470
Mucosal inflammation 16.03 10.04 18 55321 62566 64380827
Lactation disorder 15.77 10.04 6 55333 185 64443208
Haematochezia 15.60 10.04 104 55235 66269 64377124
Hyperlactacidaemia 15.58 10.04 20 55319 4824 64438569
Pain 15.58 10.04 359 54980 553152 63890241
Hypersensitivity 15.36 10.04 102 55237 196350 64247043
Cardiac dysfunction 15.35 10.04 16 55323 3090 64440303
International normalised ratio increased 15.12 10.04 118 55221 79049 64364344
Autoimmune haemolytic anaemia 15.06 10.04 24 55315 7052 64436341
Cellulitis 14.91 10.04 134 55205 93523 64349870
Thermohypoaesthesia 14.86 10.04 5 55334 107 64443286
Respiratory tract malformation 14.69 10.04 4 55335 40 64443353
Pancreatic mass 14.68 10.04 11 55328 1373 64442020
Wound 14.65 10.04 27 55312 76450 64366943
Blood creatine phosphokinase MM increased 14.60 10.04 4 55335 41 64443352
Abdominal distension 14.60 10.04 136 55203 95858 64347535
Hypermagnesaemia 14.57 10.04 10 55329 1087 64442306
Therapeutic response decreased 14.51 10.04 14 55325 52174 64391219
Sight disability 14.44 10.04 5 55334 117 64443276
Accidental overdose 14.36 10.04 62 55277 33495 64409898
Folliculitis 14.35 10.04 4 55335 30073 64413320
Renal arteriosclerosis 14.23 10.04 6 55333 243 64443150
Syncope 13.92 10.04 201 55138 157434 64285959
Abdominal pain 13.73 10.04 358 54981 312017 64131376
Maternal condition affecting foetus 13.63 10.04 5 55334 139 64443254
Lower gastrointestinal haemorrhage 13.49 10.04 34 55305 13905 64429488
Epistaxis 13.43 10.04 136 55203 97995 64345398
Foreign body aspiration 13.39 10.04 6 55333 282 64443111
Mobility decreased 13.38 10.04 34 55305 85806 64357587
Haemorrhagic erosive gastritis 13.27 10.04 7 55332 471 64442922
Lethargy 13.20 10.04 107 55232 72487 64370906
Poor sucking reflex 13.15 10.04 4 55335 61 64443332
Infected neoplasm 13.09 10.04 6 55333 297 64443096
Bronchopulmonary disease 12.99 10.04 3 55336 14 64443379
Sinus node dysfunction 12.97 10.04 22 55317 6806 64436587
Nasopharyngitis 12.85 10.04 107 55232 195966 64247427
Asocial behaviour 12.74 10.04 4 55335 68 64443325
Therapy interrupted 12.72 10.04 42 55297 19994 64423399
Coma 12.68 10.04 36 55303 87579 64355814
Pancreatic injury 12.65 10.04 5 55334 171 64443222
Injection site reaction 12.42 10.04 13 55326 46651 64396742
Meningism 12.32 10.04 7 55332 546 64442847
General physical health deterioration 12.31 10.04 114 55225 204311 64239082
Suicidal ideation 12.30 10.04 24 55315 66518 64376875
Acidosis 11.92 10.04 38 55301 17757 64425636
Exposure during pregnancy 11.78 10.04 110 55229 77565 64365828
Radiation proctitis 11.78 10.04 4 55335 88 64443305
Inability to afford medication 11.70 10.04 11 55328 1875 64441518
Inflammation 11.69 10.04 24 55315 65276 64378117
Rash 11.63 10.04 302 55037 458247 63985146
Sepsis 11.61 10.04 269 55070 230072 64213321
Psoriatic arthropathy 11.59 10.04 12 55327 43269 64400124
Hip fracture 11.54 10.04 50 55289 27049 64416344
Hepatic encephalopathy 11.49 10.04 42 55297 21024 64422369
Ludwig angina 11.49 10.04 5 55334 219 64443174
Clostridium difficile colitis 11.42 10.04 50 55289 27173 64416220
Depressed level of consciousness 11.39 10.04 34 55305 81402 64361991
Arteriovenous malformation 11.36 10.04 10 55329 1566 64441827
Premature labour 11.24 10.04 22 55317 7598 64435795
Small intestinal obstruction 11.22 10.04 45 55294 23528 64419865
Internal haemorrhage 11.14 10.04 22 55317 7645 64435748
Blood iron decreased 11.11 10.04 29 55310 12113 64431280
Haemoglobin abnormal 10.95 10.04 19 55320 5985 64437408
Pneumocystis jirovecii pneumonia 10.93 10.04 5 55334 27629 64415764
Cellulitis orbital 10.91 10.04 7 55332 680 64442713
Abdominal discomfort 10.84 10.04 102 55237 182220 64261173
Hepatic cirrhosis 10.80 10.04 48 55291 26250 64417143
Sinusitis 10.79 10.04 77 55262 145851 64297542
Failure to thrive 10.73 10.04 26 55313 10378 64433015
Renal tubular acidosis 10.70 10.04 13 55326 2966 64440427
Regurgitation 10.66 10.04 11 55328 2098 64441295
Rectal haemorrhage 10.64 10.04 90 55249 61727 64381666
Musculoskeletal pain 10.63 10.04 35 55304 81259 64362134
Crystal urine 10.61 10.04 4 55335 120 64443273
Sopor 10.61 10.04 52 55287 29609 64413784
Inflammatory bowel disease 10.51 10.04 16 55323 4522 64438871
Uterine haemorrhage 10.50 10.04 12 55327 2567 64440826
Antipsychotic drug level increased 10.41 10.04 17 55322 5098 64438295
Suicide attempt 10.41 10.04 29 55310 70978 64372415
Haemorrhage 10.40 10.04 109 55230 79242 64364151
Oxygen consumption increased 10.39 10.04 16 55323 4565 64438828
Unwanted awareness during anaesthesia 10.33 10.04 5 55334 280 64443113
Infection 10.33 10.04 105 55234 184775 64258618
Enterocolitis bacterial 10.33 10.04 6 55333 488 64442905
Dehydration 10.27 10.04 251 55088 216512 64226881
Hyponatraemic seizure 10.25 10.04 6 55333 495 64442898
Colon cancer 10.23 10.04 29 55310 12710 64430683
Chest pain 10.23 10.04 270 55069 235710 64207683
Colitis ulcerative 10.20 10.04 43 55296 22985 64420408
Stillbirth 10.15 10.04 14 55325 3619 64439774

FDA Adverse Event Reporting System (Pediatric)

None

Pharmacologic Action:

SourceCodeDescription
ATC B03AA07 BLOOD AND BLOOD FORMING ORGANS
ANTIANEMIC PREPARATIONS
IRON PREPARATIONS
Iron bivalent, oral preparations
ATC B03AD03 BLOOD AND BLOOD FORMING ORGANS
ANTIANEMIC PREPARATIONS
IRON PREPARATIONS
Iron in combination with folic acid
CHEBI has role CHEBI:63247 reducer

Drug Use (View source of the data)

DiseaseRelationSNOMED_IDDOID
Anemia of prematurity indication 47100003 DOID:11243
Megaloblastic anemia due to folate deficiency indication 85649008 DOID:14026
Vitamin deficiency indication 85670002
Iron deficiency anemia indication 87522002
Mineral deficiency indication 111379007
Mineral Deficiency Prevention indication
Vitamin Deficiency Prevention indication
Peptic ulcer contraindication 13200003 DOID:750
Operation on stomach contraindication 16453004
Primary hyperoxaluria contraindication 17901006 DOID:2977
Gastroenteritis contraindication 25374005 DOID:2326
Hemosiderosis contraindication 39011001 DOID:12119
Hemolytic anemia contraindication 61261009 DOID:583
Ulcerative colitis contraindication 64766004 DOID:8577
Anemia due to enzyme deficiency contraindication 111577008
Hb SS disease contraindication 127040003 DOID:10923
Esophageal dysmotility contraindication 266434009 DOID:9192
Diverticular disease contraindication 397881000
Hemochromatosis contraindication 399187006 DOID:2352
Repeated Blood Transfusions contraindication




๐Ÿถ Veterinary Drug Use

None

๐Ÿถ Veterinary products

None

Acid dissociation constants calculated using MoKa v3.0.0

None

Orange Book patent data (new drug applications)

None

Orange Book exclusivity data (new drug applications)

None

Bioactivity Summary:

None

External reference:

IDSource
D04172 KEGG_DRUG
4017707 VUID
N0000146077 NUI
4017662 VANDF
4017664 VANDF
4017707 VANDF
CHEBI:75832 CHEBI
CHEMBL1200830 ChEMBL_ID
C020748 MESH_SUPPLEMENTAL_RECORD_UI
39R4TAN1VT UNII
24393 PUBCHEM_CID
24947 RXNORM
4725 MMSL
4920 MMSL
6168 MMSL
63844 MMSL
d03824 MMSL
000840 NDDF
007813 NDDF
387402000 SNOMEDCT_US
71724000 SNOMEDCT_US
C0060282 UMLSCUI
7782-63-0 SECONDARY_CAS_RN

Pharmaceutical products:

ProductCategoryIngredientsNDCFormQuantityRouteMarketingLabel
Quflora FE Pediatric Drops HUMAN PRESCRIPTION DRUG LABEL 14 15370-102 LIQUID 9.50 mg ORAL UNAPPROVED DRUG OTHER 11 sections
FERROUS SULFATE HUMAN OTC DRUG LABEL 1 50436-5890 TABLET 325 mg ORAL Unapproved drug other 10 sections
FERROUS SULFATE HUMAN OTC DRUG LABEL 1 53807-177 ELIXIR 220 mg ORAL UNAPPROVED DRUG OTHER 15 sections
FERROUS SULFATE HUMAN OTC DRUG LABEL 1 53808-0918 TABLET 325 mg ORAL UNAPPROVED DRUG OTHER 10 sections
Ferrous Sulfate HUMAN OTC DRUG LABEL 1 54738-963 TABLET 325 mg ORAL unapproved drug other 11 sections
Ferrous Sulfate HUMAN OTC DRUG LABEL 1 54738-963 TABLET 325 mg ORAL unapproved drug other 11 sections
FERROUS SULFATE HUMAN OTC DRUG LABEL 2 58607-113 TABLET 65 mg ORAL unapproved drug other 9 sections
Multi-Vitamin Drops with Fluoride and Iron HUMAN PRESCRIPTION DRUG LABEL 10 58657-327 LIQUID 10 mg ORAL unapproved drug other 10 sections
Ferrous Sulfate HUMAN OTC DRUG LABEL 1 67296-1555 TABLET, FILM COATED 325 mg ORAL unapproved drug other 10 sections
Ferrous Sulfate HUMAN PRESCRIPTION DRUG LABEL 1 69517-133 TABLET 65 mg ORAL unapproved drug other 6 sections
Ferrous Sulfate Human OTC Drug Label 1 76413-308 TABLET, FILM COATED 325 mg ORAL UNAPPROVED DRUG OTHER 10 sections
Ferrous Sulfate Human OTC Drug Label 1 76413-356 TABLET, FILM COATED 325 mg ORAL UNAPPROVED DRUG OTHER 11 sections