All FDA-approved EMA-approved PMDA-approved
Target Card Uniprot Example: P23975

ferrous sulfate 🐶 Veterinary Use | Indications/Contra | FAERs-F | FAERs-M | Orange Bk | PK/Tox | Related Drugs | BioActivity |

Stem definition	Drug id	CAS RN
	4528	7720-78-7

Description:

Molecule	Description
Synonyms: ferrous sulfate ferrous sulfate, dried	Ferro-Gradumet is ferrous sulfate in controlled release form; RN given refers to Fe(+2)[1:1] salt Molecular weight: 151.90 Formula: FeO4S CLOGP: LIPINSKI: None HAC: None HDO: None TPSA: 80.26 ALOGS: ROTB: None

Drug dosage:

Dose	Unit	Route
0.20	g	O

ADMET properties:

Property	Value	Reference
BDDCS (Biopharmaceutical Drug Disposition Classification System)	3	Benet LZ, Broccatelli F, Oprea TI
S (Water solubility)	570 mg/mL	Benet LZ, Broccatelli F, Oprea TI
MRTD (Maximum Recommended Therapeutic Daily Dose)	30.56 µM/kg/day	Contrera JF, Matthews EJ, Kruhlak NL, Benz RD

Predicted pharmacokinetic/toxicological properties (PK-AZ):

None

Approvals:

Date	Agency	Company	Orphan
Aug. 13, 1946	FDA	LEDERLE

FDA Adverse Event Reporting System (Female)

MedDRA adverse event term	Likelihood ratio	Likelihood ratio threshold	Patients taking drug having adverse event	Patients taking drug not having adverse event	Patients not taking drug having adverse event	Patients not taking drug not having adverse event
Acute kidney injury	282.01	10.37	662	62539	319725	90245521
Anaemia	199.26	10.37	619	62582	352183	90213063
Synovitis	188.99	10.37	10	63191	329742	90235504
Hand deformity	183.39	10.37	5	63196	296357	90268889
Glossodynia	177.61	10.37	12	63189	321767	90243479
Systemic lupus erythematosus	177.12	10.37	22	63179	361874	90203372
Drug ineffective	172.49	10.37	452	62749	1383846	89181400
Pericarditis	149.29	10.37	10	63191	270141	90295105
Drug intolerance	137.95	10.37	70	63131	447521	90117725
Contraindicated product administered	131.34	10.37	31	63170	320108	90245138
Wound	124.96	10.37	29	63172	302951	90262295
Arthropathy	124.20	10.37	50	63151	366192	90199054
Folliculitis	120.91	10.37	5	63196	204348	90360898
Hepatic enzyme increased	119.49	10.37	51	63150	360685	90204561
Joint swelling	118.55	10.37	106	63095	503194	90062052
Treatment failure	115.98	10.37	34	63167	303894	90261352
Infusion related reaction	107.79	10.37	80	63121	416700	90148546
Muscle injury	105.60	10.37	4	63197	176650	90388596
Hypervolaemia	103.64	10.37	121	63080	32636	90532610
Impaired healing	99.41	10.37	21	63180	234178	90331068
Therapeutic product effect decreased	95.54	10.37	37	63164	277534	90287712
Irritable bowel syndrome	93.57	10.37	16	63185	207432	90357814
Haemoglobin decreased	92.91	10.37	286	62915	161670	90403576
Discomfort	90.47	10.37	39	63162	274296	90290950
Alopecia	88.64	10.37	130	63071	494941	90070305
Rheumatoid arthritis	86.97	10.37	75	63126	362539	90202707
Death	83.80	10.37	575	62626	455976	90109270
Mobility decreased	83.71	10.37	35	63166	250699	90314547
Gastrointestinal haemorrhage	83.00	10.37	190	63011	90058	90475188
Abdominal discomfort	80.97	10.37	130	63071	477198	90088048
Psoriatic arthropathy	77.64	10.37	31	63170	228304	90336942
Pulmonary hypertension	76.07	10.37	119	63082	42404	90522842
Hyperkalaemia	72.59	10.37	148	63053	64816	90500430
Urinary tract infection	72.34	10.37	411	62790	305221	90260025
Premature delivery	71.47	10.37	110	63091	38652	90526594
Hypersensitivity	71.45	10.37	130	63071	454547	90110699
Blister	69.77	10.37	46	63155	254952	90310294
Fibromyalgia	68.51	10.37	29	63172	206240	90359006
Musculoskeletal stiffness	67.89	10.37	64	63137	296468	90268778
General physical health deterioration	66.75	10.37	90	63111	355025	90210221
Pulmonary malformation	66.23	10.37	20	63181	370	90564876
Liver injury	65.18	10.37	19	63182	170548	90394698
Pulmonary arterial hypertension	64.01	10.37	85	63116	26102	90539144
Melaena	63.11	10.37	98	63103	34699	90530547
Fall	62.46	10.37	560	62641	481250	90083996
Hypotension	61.52	10.37	413	62788	324984	90240262
Foetal exposure during pregnancy	60.47	10.37	108	63093	42867	90522379
Hospitalisation	59.80	10.37	211	62990	127889	90437357
Lower respiratory tract infection	58.67	10.37	53	63148	250606	90314640
Drug hypersensitivity	58.35	10.37	150	63051	463459	90101787
Blood cholesterol increased	57.60	10.37	37	63164	207975	90357271
Acute respiratory failure	53.04	10.37	102	63099	42816	90522430
Grip strength decreased	52.38	10.37	3	63198	92573	90472673
Hypoxia	52.32	10.37	139	63062	72260	90492986
Product use issue	52.08	10.37	94	63107	329825	90235421
C-reactive protein increased	51.97	10.37	31	63170	181358	90383888
Bursitis	51.53	10.37	14	63187	131640	90433606
Hypophosphataemia	50.57	10.37	57	63144	14797	90550449
Lung cyst	50.28	10.37	17	63184	458	90564788
Faeces discoloured	50.27	10.37	68	63133	21252	90543994
Metabolic acidosis	49.83	10.37	116	63085	55560	90509686
Dyspnoea	49.71	10.37	876	62325	880079	89685167
Ill-defined disorder	49.69	10.37	34	63167	184857	90380389
Lip dry	49.66	10.37	6	63195	100949	90464297
Injury	49.52	10.37	39	63162	197310	90367936
Iron deficiency anaemia	49.13	10.37	71	63130	23591	90541655
Cardiac failure congestive	49.05	10.37	166	63035	98528	90466718
Sleep disorder	48.61	10.37	40	63161	197990	90367256
Stomatitis	48.25	10.37	73	63128	274625	90290621
Transfusion	47.81	10.37	60	63141	17428	90547818
Respiratory tract malformation	47.24	10.37	13	63188	170	90565076
Cardiac failure acute	46.22	10.37	49	63152	11880	90553366
Diarrhoea	46.10	10.37	914	62287	938276	89626970
Pre-eclampsia	45.71	10.37	47	63154	11001	90554245
Hypoglycaemia	45.40	10.37	129	63072	69719	90495527
Joint range of motion decreased	45.14	10.37	19	63182	135624	90429622
Right ventricular failure	44.90	10.37	61	63140	19144	90546102
Lactic acidosis	41.77	10.37	102	63099	50361	90514885
Inflammation	41.49	10.37	38	63163	178554	90386692
Sepsis	41.30	10.37	240	62961	179574	90385672
Completed suicide	41.26	10.37	25	63176	145033	90420213
Cellulitis	40.53	10.37	148	63053	91189	90474057
Swelling	40.38	10.37	153	63048	418905	90146341
Dyspnoea exertional	39.88	10.37	126	63075	72162	90493084
Autoimmune disorder	39.16	10.37	4	63197	76740	90488506
Cardiac failure	38.55	10.37	165	63036	109331	90455915
Pneumonia	37.16	10.37	638	62563	637421	89927825
Hypokalaemia	36.88	10.37	185	63016	130931	90434315
Gastrointestinal tract mucosal pigmentation	36.68	10.37	15	63186	694	90564552
Hypomagnesaemia	36.16	10.37	78	63123	35510	90529736
Arthralgia	36.11	10.37	358	62843	778164	89787082
Therapeutic product effect incomplete	35.53	10.37	50	63151	193846	90371400
Urticaria	35.00	10.37	107	63094	312627	90252619
Chronic kidney disease	34.89	10.37	95	63106	50096	90515150
Exposure via breast milk	34.49	10.37	21	63180	2294	90562952
Dehydration	34.45	10.37	243	62958	194204	90371042
Product administration interrupted	34.37	10.37	43	63158	12449	90552797
COVID-19	34.11	10.37	218	62983	168625	90396621
Hyponatraemia	33.81	10.37	183	63018	133355	90431891
Prescribed overdose	33.58	10.37	13	63188	97612	90467634
Chronic obstructive pulmonary disease	33.07	10.37	120	63081	73709	90491537
Metabolic alkalosis	33.00	10.37	24	63177	3525	90561721
Product dose omission issue	32.73	10.37	329	62872	291358	90273888
Respiratory failure	32.54	10.37	166	63035	118252	90446994
Renal failure	32.14	10.37	178	63023	130829	90434417
Congenital umbilical hernia	31.57	10.37	11	63190	325	90564921
Pulmonary fibrosis	31.31	10.37	18	63183	107485	90457761
Congenital ovarian anomaly	31.03	10.37	6	63195	12	90565234
Haematocrit decreased	30.91	10.37	81	63120	41751	90523495
Peripheral venous disease	30.87	10.37	10	63191	83911	90481335
Hypercholesterolaemia	30.69	10.37	16	63185	100876	90464370
Blood iron decreased	30.38	10.37	49	63152	17910	90547336
Haematemesis	29.88	10.37	70	63131	33656	90531590
Blood loss anaemia	29.67	10.37	36	63165	10104	90555142
Epistaxis	28.99	10.37	127	63074	84998	90480248
Pain	28.96	10.37	505	62696	995836	89569410
Musculoskeletal pain	28.64	10.37	47	63154	171204	90394042
Congenital skin dimples	28.63	10.37	8	63193	111	90565135
Atrial fibrillation	28.53	10.37	175	63026	133436	90431810
Type 2 diabetes mellitus	28.52	10.37	62	63139	203182	90362064
Full blood count abnormal	28.21	10.37	72	63129	36525	90528721
Heavy menstrual bleeding	28.12	10.37	51	63150	20479	90544767
Night sweats	28.05	10.37	29	63172	128737	90436509
Transferrin saturation increased	27.81	10.37	7	63194	63	90565183
Upper gastrointestinal haemorrhage	27.64	10.37	54	63147	22922	90542324
Transferrin increased	27.41	10.37	5	63196	6	90565240
Red blood cell sedimentation rate increased	26.79	10.37	12	63189	82583	90482663
Asthenia	26.59	10.37	521	62680	533230	90032016
Haemorrhoids	26.53	10.37	58	63143	26644	90538602
Troponin increased	26.34	10.37	39	63162	13242	90552004
Stillbirth	26.09	10.37	29	63172	7414	90557832
Infection	26.07	10.37	147	63054	361947	90203299
Constipation	25.78	10.37	304	62897	280091	90285155
Wound infection	25.48	10.37	22	63179	106380	90458866
Clostridium difficile colitis	25.40	10.37	57	63144	26649	90538597
Pulmonary oedema	25.38	10.37	98	63103	61982	90503264
Autoimmune haemolytic anaemia	25.15	10.37	25	63176	5620	90559626
Dry mouth	25.13	10.37	57	63144	184002	90381244
Syncope	24.79	10.37	168	63033	132495	90432751
Anhedonia	24.76	10.37	35	63166	11396	90553850
Mental status changes	24.75	10.37	78	63123	44601	90520645
Blood creatinine increased	24.36	10.37	137	63064	101249	90463997
Hypothyroidism	24.34	10.37	87	63114	53040	90512206
Osteoarthritis	23.31	10.37	65	63136	195665	90369581
Maternal exposure during breast feeding	23.13	10.37	25	63176	6195	90559051
Infective pulmonary exacerbation of cystic fibrosis	23.05	10.37	32	63169	10247	90554999
Intentional product use issue	22.99	10.37	76	63125	216816	90348430
Hepatic encephalopathy	22.51	10.37	37	63164	13735	90551511
Sinus polyp degeneration	22.51	10.37	6	63195	69	90565177
Haemorrhage	22.49	10.37	102	63099	69267	90495979
International normalised ratio increased	22.12	10.37	78	63123	47238	90518008
Haemoptysis	22.10	10.37	62	63139	33258	90531988
Therapy interrupted	22.06	10.37	81	63120	50027	90515219
Gastrointestinal disorder	22.02	10.37	98	63103	256589	90308657
Onychomadesis	21.98	10.37	3	63198	45995	90519251
Product confusion	21.87	10.37	7	63194	158	90565088
Platelet count decreased	21.86	10.37	167	63034	136802	90428444
Sopor	21.67	10.37	51	63150	24593	90540653
Hypovolaemia	21.14	10.37	34	63167	12397	90552849
Nasopharyngitis	21.06	10.37	182	63019	406922	90158324
Wheezing	20.96	10.37	90	63111	237990	90327256
Clostridium difficile infection	20.75	10.37	64	63137	36181	90529065
Gingival hypertrophy	20.74	10.37	15	63186	2185	90563061
Diastasis recti abdominis	20.73	10.37	5	63196	37	90565209
Haematochezia	20.60	10.37	101	63100	70812	90494434
Gastritis	20.53	10.37	70	63131	41683	90523563
Nail disorder	20.09	10.37	8	63193	59059	90506187
Transfusion-associated dyspnoea	20.07	10.37	5	63196	43	90565203
Prescribed underdose	19.87	10.37	14	63187	75005	90490241
Drug abuse	19.75	10.37	17	63184	82330	90482916
Internal haemorrhage	19.71	10.37	23	63178	6197	90559049
Epilepsy	19.68	10.37	17	63184	82189	90483057
Glucocorticoids increased	19.43	10.37	6	63195	120	90565126
Hypothermia	19.22	10.37	37	63164	15538	90549708
Fluid retention	19.19	10.37	116	63085	87975	90477271
Thermohypoaesthesia	19.11	10.37	6	63195	127	90565119
Thrombosis	18.95	10.37	101	63100	73150	90492096
Therapy non-responder	18.93	10.37	42	63159	136662	90428584
Oesophagitis	18.91	10.37	39	63162	17210	90548036
Uterine leiomyoma	18.87	10.37	30	63171	10834	90554412
Hyperglycaemia	18.86	10.37	78	63123	50892	90514354
Sinus node dysfunction	18.82	10.37	21	63180	5391	90559855
Sciatica	18.71	10.37	26	63175	101356	90463890
Gait inability	18.68	10.37	47	63154	146409	90418837
Lower limb fracture	18.68	10.37	19	63182	84994	90480252
Hospice care	18.53	10.37	28	63173	9676	90555570
Exostosis	18.40	10.37	7	63194	53127	90512119
Lethargy	18.39	10.37	90	63111	63049	90502197
Oesophageal injury	18.34	10.37	5	63196	63	90565183
Sight disability	18.17	10.37	6	63195	150	90565096
Lactation disorder	18.15	10.37	8	63193	446	90564800
Urine output decreased	18.15	10.37	32	63169	12571	90552675
Abnormal cord insertion	18.09	10.37	4	63197	19	90565227
Non-cardiogenic pulmonary oedema	17.97	10.37	11	63190	1213	90564033
Illness	17.90	10.37	108	63093	81861	90483385
Knee arthroplasty	17.81	10.37	19	63182	83163	90482083
Vaginal haemorrhage	17.70	10.37	55	63146	31216	90534030
Postpartum haemorrhage	17.41	10.37	14	63187	2387	90562859
Duodenitis	17.04	10.37	18	63183	4345	90560901
Rash	17.02	10.37	424	62777	795676	89769570
Nasal congestion	17.02	10.37	108	63093	83306	90481940
Cough	16.97	10.37	356	62845	368606	90196640
Lung disorder	16.95	10.37	51	63150	149832	90415414
Discharge	16.56	10.37	12	63189	1752	90563494
Blepharospasm	16.55	10.37	9	63192	55436	90509810
Neuroleptic malignant syndrome	16.39	10.37	34	63167	15062	90550184
Back injury	16.38	10.37	6	63195	46616	90518630
Off label use	16.24	10.37	617	62584	1101635	89463611
Lower gastrointestinal haemorrhage	16.06	10.37	25	63176	8867	90556379
Abdominal pain	16.04	10.37	375	62826	395346	90169900
Wrong patient	16.01	10.37	9	63192	848	90564398
Foetal malnutrition	15.96	10.37	5	63196	105	90565141
Ischaemic gastritis	15.87	10.37	3	63198	5	90565241
Maternal condition affecting foetus	15.87	10.37	6	63195	225	90565021
Blood urea increased	15.85	10.37	52	63149	30361	90534885
Hypoosmolar state	15.82	10.37	6	63195	227	90565019
Haemoglobin abnormal	15.76	10.37	22	63179	7078	90558168
Blood creatine phosphokinase MM increased	15.70	10.37	4	63197	38	90565208
Hip arthroplasty	15.67	10.37	18	63183	76190	90489056
Azotaemia	15.67	10.37	19	63182	5329	90559917
Threatened labour	15.61	10.37	9	63192	889	90564357
Blood pressure abnormal	15.51	10.37	39	63162	19606	90545640
Secretion discharge	15.20	10.37	34	63167	15862	90549384
Drug interaction	15.16	10.37	274	62927	276179	90289067
Poor sucking reflex	15.12	10.37	7	63194	438	90564808
Congenital cystic lung	15.09	10.37	4	63197	45	90565201
Atrial flutter	15.08	10.37	27	63174	10731	90554515
Contusion	14.98	10.37	108	63093	251108	90314138
Agranulocytosis	14.92	10.37	56	63145	34946	90530300
Full blood count decreased	14.80	10.37	50	63151	29639	90535607
Injection site reaction	14.72	10.37	26	63175	92054	90473192
Essential hypertension	14.67	10.37	20	63181	6295	90558951
Palatal polyp	14.65	10.37	3	63198	9	90565237
Oxygen consumption increased	14.59	10.37	17	63184	4572	90560674
Haemoperitoneum	14.58	10.37	15	63186	3513	90561733
Haemorrhagic erosive gastritis	14.36	10.37	7	63194	492	90564754
Blood alkaline phosphatase increased	14.34	10.37	69	63132	48010	90517236
Portal hypertensive gastropathy	14.34	10.37	9	63192	1038	90564208
Myelosuppression	14.20	10.37	10	63191	53581	90511665
Carbuncle	14.01	10.37	10	63191	1426	90563820
Genital prolapse	13.91	10.37	4	63197	62	90565184
Bradycardia	13.80	10.37	103	63098	83744	90481502
Ketosis	13.78	10.37	8	63193	801	90564445
Glomerular filtration rate decreased	13.77	10.37	34	63167	16898	90548348
Left ventricular failure	13.76	10.37	20	63181	6680	90558566
Renal tubular acidosis	13.69	10.37	12	63189	2303	90562943
Presyncope	13.65	10.37	51	63150	31754	90533492
Balance disorder	13.65	10.37	115	63086	96965	90468281
Diabetic ketosis	13.58	10.37	7	63194	554	90564692
Periodontitis	13.48	10.37	15	63186	3838	90561408
Insurance issue	13.48	10.37	26	63175	10932	90554314
Haemoglobin increased	13.46	10.37	21	63180	7460	90557786
Euglycaemic diabetic ketoacidosis	13.45	10.37	19	63182	6182	90559064
Nocturia	13.44	10.37	25	63176	10230	90555016
Drug ineffective for unapproved indication	13.42	10.37	16	63185	66628	90498618
Road traffic accident	13.37	10.37	35	63166	107591	90457655
Sinusitis	13.36	10.37	164	63037	342924	90222322
Renal arteriosclerosis	13.36	10.37	5	63196	182	90565064
Iron deficiency	13.32	10.37	24	63177	9588	90555658
Blood iron increased	13.31	10.37	11	63190	1948	90563298
Scleroderma	13.31	10.37	19	63182	6242	90559004
Arteriovenous malformation	13.30	10.37	10	63191	1545	90563701
Enuresis	13.19	10.37	14	63187	3400	90561846
Respiratory distress	13.17	10.37	58	63143	38888	90526358
Abdominal distension	13.07	10.37	144	63057	130457	90434789
Metabolic surgery	12.99	10.37	10	63191	1601	90563645
Inflammatory bowel disease	12.97	10.37	17	63184	5154	90560092
Infected neoplasm	12.95	10.37	6	63195	376	90564870
Dyspepsia	12.90	10.37	83	63118	198077	90367169
Therapeutic response decreased	12.89	10.37	27	63174	89702	90475544
Blood albumin decreased	12.89	10.37	33	63168	16770	90548476
Hypermagnesaemia	12.89	10.37	9	63192	1240	90564006
Palpitations	12.89	10.37	149	63052	136579	90428667
Onychomycosis	12.81	10.37	5	63196	37371	90527875
Angina unstable	12.78	10.37	20	63181	7123	90558123
Laryngitis	12.76	10.37	10	63191	50743	90514503
Peritoneal disorder	12.66	10.37	7	63194	638	90564608
Urosepsis	12.63	10.37	38	63163	21194	90544052
Small intestinal obstruction	12.62	10.37	38	63163	21196	90544050
Gestational hypertension	12.62	10.37	13	63188	3049	90562197
Obesity	12.58	10.37	35	63166	105472	90459774
Pyuria	12.56	10.37	11	63190	2108	90563138
Unwanted awareness during anaesthesia	12.55	10.37	6	63195	404	90564842
Rhinovirus infection	12.53	10.37	18	63183	5945	90559301
Chronic hepatic failure	12.52	10.37	7	63194	652	90564594
Nasal obstruction	12.45	10.37	12	63189	2600	90562646
Blood glucose increased	12.44	10.37	111	63090	95135	90470111
Umbilical discharge	12.39	10.37	4	63197	93	90565153
Coeliac disease	12.25	10.37	8	63193	44602	90520644
Cholestasis	12.23	10.37	54	63147	36245	90529001
Rectal haemorrhage	12.16	10.37	99	63102	82645	90482601
Somnolence	12.09	10.37	209	62992	208875	90356371
Intentional product misuse	12.02	10.37	28	63173	89576	90475670
Upper airway obstruction	11.99	10.37	8	63193	1024	90564222
Vitamin D deficiency	11.97	10.37	33	63168	17523	90547723
Adverse reaction	11.93	10.37	3	63198	29709	90535537
Urinary retention	11.86	10.37	55	63146	37689	90527557
Adverse event	11.86	10.37	42	63159	117376	90447870
Renal impairment	11.85	10.37	119	63082	105302	90459944
Haematoma muscle	11.77	10.37	10	63191	1840	90563406
Hip fracture	11.75	10.37	50	63151	33027	90532219
Intentional dose omission	11.70	10.37	33	63168	17750	90547496
Application site haematoma	11.63	10.37	3	63198	30	90565216
Drug tolerance decreased	11.52	10.37	4	63197	32126	90533120
Sedation	11.48	10.37	10	63191	48161	90517085
Back pain	11.47	10.37	296	62905	316879	90248367
Flatulence	11.36	10.37	58	63143	41309	90523937
Foetal death	11.31	10.37	36	63165	20687	90544559
Hyponatraemic seizure	11.31	10.37	6	63195	504	90564742
Oedema peripheral	11.25	10.37	247	62954	257668	90307578
N-terminal prohormone brain natriuretic peptide increased	11.18	10.37	12	63189	2950	90562296
Hyperdynamic left ventricle	11.18	10.37	5	63196	289	90564957
Total bile acids increased	11.15	10.37	4	63197	129	90565117
Pericardial effusion	11.08	10.37	53	63148	36780	90528466
Internal fixation of fracture	11.08	10.37	7	63194	817	90564429
Subdural haematoma	11.06	10.37	31	63170	16614	90548632
Meningism	11.04	10.37	6	63195	529	90564717
Gastric antral vascular ectasia	11.04	10.37	7	63194	822	90564424
Cardiac hypertrophy	11.03	10.37	8	63193	1170	90564076
Hypophagia	11.02	10.37	52	63149	35885	90529361
Surgery	11.01	10.37	61	63140	44826	90520420
Brain natriuretic peptide increased	11.01	10.37	17	63184	5988	90559258
Uterine haemorrhage	10.96	10.37	15	63186	4737	90560509
Haematoma	10.90	10.37	55	63146	38993	90526253
Endometritis	10.90	10.37	8	63193	1192	90564054
Meconium in amniotic fluid	10.71	10.37	5	63196	319	90564927
Abnormal loss of weight	10.71	10.37	18	63183	6805	90558441
Diabetes mellitus inadequate control	10.70	10.37	33	63168	18651	90546595
Gastrointestinal arteriovenous malformation	10.64	10.37	6	63195	569	90564677
Exposure during pregnancy	10.61	10.37	229	62972	238181	90327065
Bronchial wall thickening	10.55	10.37	10	63191	2121	90563125
Sinus arrest	10.49	10.37	10	63191	2136	90563110
Emotional distress	10.49	10.37	52	63149	36610	90528636
Right ventricular dilatation	10.43	10.37	9	63192	1690	90563556
Varices oesophageal	10.38	10.37	13	63188	3766	90561480

FDA Adverse Event Reporting System (Male)

MedDRA adverse event term	Likelihood ratio	Likelihood ratio threshold	Patients taking drug having adverse event	Patients taking drug not having adverse event	Patients not taking drug having adverse event	Patients not taking drug not having adverse event
Drug ineffective	109.05	11.01	219	34500	629978	41956638
Acute kidney injury	83.09	11.01	547	34172	366790	42219826
Hyperkalaemia	63.57	11.01	176	34543	80282	42506334
Foetal exposure during pregnancy	60.73	11.01	125	34594	47186	42539430
Foetal disorder	59.59	11.01	25	34694	1054	42585562
Anaemia	57.06	11.01	407	34312	279871	42306745
Gastrointestinal haemorrhage	52.47	11.01	187	34532	97539	42489077
Neutropenia neonatal	49.75	11.01	21	34698	899	42585717
Completed suicide	48.03	11.01	10	34709	96455	42490161
Gastrointestinal tract mucosal pigmentation	48.03	11.01	18	34701	561	42586055
Hospitalisation	47.66	11.01	151	34568	74179	42512437
Premature baby	46.06	11.01	74	34645	23079	42563537
Haemoglobin decreased	45.52	11.01	221	34498	132250	42454366
Encephalitis toxic	44.02	11.01	14	34705	263	42586353
Faeces discoloured	41.81	11.01	60	34659	16954	42569662
Toxicity to various agents	41.65	11.01	77	34642	229059	42357557
Low birth weight baby	40.24	11.01	45	34674	9910	42576706
Lymph node calcification	38.20	11.01	11	34708	145	42586471
Death	36.20	11.01	561	34158	470624	42115992
Periodontitis	34.87	11.01	22	34697	2189	42584427
Asthenia	33.18	11.01	362	34357	280431	42306185
Blood loss anaemia	31.06	11.01	39	34680	9697	42576919
Febrile neutropenia	27.43	11.01	70	34649	185633	42400983
Iron deficiency anaemia	26.38	11.01	42	34677	12997	42573619
Normocytic anaemia	25.39	11.01	22	34697	3555	42583061
Drug abuse	25.09	11.01	29	34690	104742	42481874
Fibrin D dimer increased	24.51	11.01	25	34694	4960	42581656
Cardiac dysfunction	24.32	11.01	21	34698	3378	42583238
Transfusion	24.27	11.01	36	34683	10478	42576138
Fall	23.94	11.01	294	34425	234226	42352390
Upper gastrointestinal haemorrhage	23.62	11.01	66	34653	30233	42556383
Therapy interrupted	23.10	11.01	54	34665	22196	42564420
Hyperlactacidaemia	22.84	11.01	23	34696	4493	42582123
Drug ineffective for unapproved indication	22.53	11.01	5	34714	46158	42540458
Gastrointestinal angiodysplasia	22.46	11.01	11	34708	667	42585949
Clostridium difficile infection	22.45	11.01	54	34665	22605	42564011
Diarrhoea	21.94	11.01	510	34209	460339	42126277
Urinary tract infection	21.77	11.01	147	34572	99137	42487479
Red blood cell sedimentation rate decreased	20.83	11.01	8	34711	267	42586349
Pancreatic duct stenosis	19.98	11.01	7	34712	179	42586437
Foreign body aspiration	19.61	11.01	8	34711	314	42586302
Lower gastrointestinal haemorrhage	19.42	11.01	33	34686	10775	42575841
Implant site inflammation	19.32	11.01	6	34713	104	42586512
Full blood count decreased	19.30	11.01	48	34671	20512	42566104
Pancreatic calcification	19.25	11.01	7	34712	200	42586416
Congenital umbilical hernia	18.83	11.01	8	34711	348	42586268
Decreased appetite	18.78	11.01	240	34479	192897	42393719
Pancreatic mass	18.78	11.01	11	34708	957	42585659
Mental impairment	18.77	11.01	35	34684	12282	42574334
Hypervolaemia	18.65	11.01	51	34668	23074	42563542
Neglect of personal appearance	18.53	11.01	8	34711	362	42586254
Ventricular septal defect	17.98	11.01	20	34699	4379	42582237
Gingival hypertrophy	17.31	11.01	15	34704	2424	42584192
Cardiac ventricular disorder	17.03	11.01	7	34712	280	42586336
Dyspnoea	16.97	11.01	476	34243	442145	42144471
Myelosuppression	16.75	11.01	6	34713	40455	42546161
Essential thrombocythaemia	16.48	11.01	6	34713	172	42586444
Mental status changes	16.45	11.01	73	34646	42042	42544574
Fatigue	16.28	11.01	467	34252	435174	42151442
Cortical visual impairment	15.48	11.01	4	34715	34	42586582
Treatment failure	15.35	11.01	17	34702	62607	42524009
Hospice care	15.30	11.01	26	34693	8487	42578129
Exposure during pregnancy	15.22	11.01	26	34693	8522	42578094
Haematemesis	14.68	11.01	56	34663	30143	42556473
Therapeutic product effect incomplete	14.56	11.01	22	34697	70917	42515699
Interstitial lung disease	14.55	11.01	26	34693	78436	42508180
Benign soft tissue neoplasm	14.53	11.01	5	34714	121	42586495
Hypotension	14.41	11.01	292	34427	257339	42329277
Clostridium difficile colitis	14.37	11.01	44	34675	21208	42565408
Colon injury	14.27	11.01	5	34714	128	42586488
Body temperature abnormal	14.00	11.01	9	34710	925	42585691
Tendinous contracture	13.88	11.01	5	34714	139	42586477
Hepatic function abnormal	13.77	11.01	13	34706	51554	42535062
Drug-induced liver injury	13.73	11.01	7	34712	38266	42548350
Mucosal inflammation	13.72	11.01	12	34707	49362	42537254
Off label use	13.46	11.01	407	34312	637928	41948688
Failure to thrive	13.40	11.01	26	34693	9396	42577220
Cytomegalovirus infection	13.02	11.01	5	34714	32301	42554315
Dysaesthesia	12.89	11.01	13	34706	2544	42584072
Parkinsonian rest tremor	12.89	11.01	6	34713	325	42586291
Hydrocele	12.78	11.01	13	34706	2570	42584046
Depressed mood	12.74	11.01	45	34674	23339	42563277
Product use in unapproved indication	12.69	11.01	93	34626	184363	42402253
Asocial behaviour	12.68	11.01	4	34715	73	42586543
Drug resistance	12.68	11.01	6	34713	34242	42552374
Fistula discharge	12.60	11.01	9	34710	1099	42585517
Flight of ideas	12.60	11.01	6	34713	342	42586274
Fluid retention	12.49	11.01	55	34664	31564	42555052
Capillaritis	12.48	11.01	12	34707	2216	42584400
Crystal urine	12.44	11.01	4	34715	78	42586538
Respiratory distress	12.40	11.01	67	34652	41753	42544863
Lip blister	12.30	11.01	8	34711	839	42585777
Cardiac failure congestive	12.29	11.01	115	34604	85487	42501129
Serotonin syndrome	12.21	11.01	3	34716	25842	42560774
Pancreatic injury	12.14	11.01	5	34714	201	42586415
Intracardiac mass	12.09	11.01	5	34714	203	42586413
Hypovolaemia	12.06	11.01	28	34691	11457	42575159
Enterocolitis bacterial	11.96	11.01	6	34713	383	42586233
Regurgitation	11.93	11.01	11	34708	1929	42584687
Nasal flaring	11.88	11.01	3	34716	23	42586593
Ludwig angina	11.87	11.01	5	34714	213	42586403
Chronic kidney disease	11.60	11.01	72	34647	47169	42539447
Depression	11.56	11.01	49	34670	111314	42475302
Acute respiratory failure	11.35	11.01	62	34657	38796	42547820
Joint swelling	11.34	11.01	24	34695	67998	42518618
Haemoptysis	11.11	11.01	70	34649	46097	42540519

FDA Adverse Event Reporting System (Geriatric)

MedDRA adverse event term	Likelihood ratio	Likelihood ratio threshold	Patients taking drug having adverse event	Patients taking drug not having adverse event	Patients not taking drug having adverse event	Patients not taking drug not having adverse event
Acute kidney injury	348.09	9.97	1157	81847	634273	109872022
Anaemia	219.91	9.97	902	82102	546184	109960111
Drug ineffective	210.13	9.97	526	82478	1520014	108986281
Synovitis	162.74	9.97	11	82993	274081	110232214
Hand deformity	149.16	9.97	3	83001	218503	110287792
Hyperkalaemia	143.76	9.97	316	82688	135480	110370815
Gastrointestinal haemorrhage	136.03	9.97	349	82655	165169	110341126
Systemic lupus erythematosus	132.96	9.97	17	82987	254321	110251974
Haemoglobin decreased	126.90	9.97	443	82561	248284	110258011
Duodenal ulcer perforation	119.09	9.97	3	83001	177697	110328598
Drug intolerance	118.33	9.97	80	82924	406432	110099863
Glossodynia	118.09	9.97	14	82990	221990	110284305
Death	116.78	9.97	910	82094	697959	109808336
Helicobacter infection	115.08	9.97	5	82999	181872	110324423
Joint swelling	113.81	9.97	99	82905	442746	110063549
Hypervolaemia	112.43	9.97	161	82843	49299	110456996
Pericarditis	111.31	9.97	16	82988	219098	110287197
Folliculitis	101.66	9.97	6	82998	167647	110338648
Faeces discoloured	96.18	9.97	123	82881	33825	110472470
Arthropathy	95.82	9.97	48	82956	287474	110218821
Contraindicated product administered	92.95	9.97	35	82969	248232	110258063
Treatment failure	92.81	9.97	46	82958	277188	110229107
Hepatic enzyme increased	92.22	9.97	64	82940	320828	110185467
Impaired healing	91.87	9.97	18	82986	196699	110309596
Completed suicide	91.03	9.97	34	82970	242347	110263948
Infusion related reaction	85.48	9.97	96	82908	381066	110125229
Gastrointestinal tract mucosal pigmentation	84.75	9.97	33	82971	1244	110505051
Wound	82.96	9.97	36	82968	234401	110271894
Irritable bowel syndrome	81.09	9.97	13	82991	164202	110342093
Therapeutic product effect decreased	81.08	9.97	41	82963	244275	110262020
Fall	77.68	9.97	742	82262	602740	109903555
Fibromyalgia	77.00	9.97	17	82987	170892	110335403
Hospitalisation	73.65	9.97	255	82749	142238	110364057
Pulmonary hypertension	71.92	9.97	140	82864	55080	110451215
Psoriatic arthropathy	71.56	9.97	29	82975	196732	110309563
Transfusion	70.13	9.97	91	82913	25381	110480914
Mobility decreased	70.01	9.97	46	82958	237376	110268919
Dyspnoea	69.92	9.97	1192	81812	1105680	109400615
Urinary tract infection	69.55	9.97	451	82553	325831	110180464
Alopecia	67.36	9.97	106	82898	364647	110141648
Discomfort	66.91	9.97	39	82965	214668	110291627
Blood cholesterol increased	65.97	9.97	28	82976	184757	110321538
Iron deficiency anaemia	64.88	9.97	98	82906	31461	110474834
Bursitis	64.78	9.97	10	82994	129908	110376387
Hypotension	64.38	9.97	638	82366	523211	109983084
Rheumatoid arthritis	63.36	9.97	79	82925	299534	110206761
Drug hypersensitivity	63.11	9.97	156	82848	453934	110052361
Melaena	62.79	9.97	151	82853	68606	110437689
Musculoskeletal stiffness	62.14	9.97	71	82933	279751	110226544
Lip dry	59.42	9.97	4	83000	100079	110406216
Inflammation	58.94	9.97	36	82968	193202	110313093
Pulmonary arterial hypertension	58.44	9.97	95	82909	32473	110473822
Cardiac failure congestive	58.09	9.97	246	82758	150754	110355541
Haematemesis	56.34	9.97	132	82872	58976	110447319
Hypoxia	56.17	9.97	219	82785	129296	110376999
Upper gastrointestinal haemorrhage	55.74	9.97	119	82885	49977	110456318
Pulmonary malformation	55.64	9.97	16	82988	229	110506066
Blood loss anaemia	52.14	9.97	66	82938	17959	110488336
Liver injury	50.25	9.97	25	82979	150388	110355907
Blister	50.14	9.97	58	82946	227318	110278977
Periodontitis	50.08	9.97	37	82967	5171	110501124
Acute respiratory failure	49.18	9.97	146	82858	75114	110431181
Hypersensitivity	47.09	9.97	151	82853	403847	110102448
Toxicity to various agents	46.55	9.97	194	82810	480361	110025934
Diarrhoea	45.72	9.97	1148	81856	1138357	109367938
Ill-defined disorder	45.41	9.97	31	82973	156822	110349473
Cardiac failure	45.37	9.97	268	82736	187358	110318937
Lactic acidosis	45.28	9.97	163	82841	92648	110413647
Mental status changes	44.46	9.97	142	82862	75980	110430315
Urticaria	43.92	9.97	110	82894	318747	110187548
Therapeutic product effect incomplete	43.26	9.97	63	82941	223742	110282553
Stomatitis	43.12	9.97	86	82918	270156	110236139
Cardiac failure acute	42.88	9.97	70	82934	24008	110482287
Drug abuse	41.60	9.97	43	82961	177368	110328927
Metabolic acidosis	41.10	9.97	166	82838	99578	110406717
Abdominal discomfort	40.66	9.97	155	82849	393703	110112592
Lung cyst	40.38	9.97	15	82989	496	110505799
Encephalitis toxic	40.04	9.97	13	82991	285	110506010
Hypoglycaemia	39.97	9.97	183	82821	115921	110390374
Gingival hypertrophy	39.93	9.97	30	82974	4301	110501994
Chronic kidney disease	39.81	9.97	137	82867	76154	110430141
Clostridium difficile infection	38.80	9.97	106	82898	52023	110454272
Sleep disorder	38.31	9.97	56	82948	198588	110307707
Hyponatraemia	38.18	9.97	287	82717	217366	110288929
Joint range of motion decreased	38.13	9.97	22	82982	121810	110384485
General physical health deterioration	37.37	9.97	178	82826	425117	110081178
Arthralgia	37.15	9.97	390	82614	779242	109727053
Dehydration	37.02	9.97	346	82658	279165	110227130
Dyspnoea exertional	36.55	9.97	165	82839	103895	110402400
Injury	36.16	9.97	48	82956	177217	110329078
Lower gastrointestinal haemorrhage	36.02	9.97	56	82948	18430	110487865
Asthenia	35.33	9.97	719	82285	688280	109818015
Right ventricular failure	35.26	9.97	67	82937	25887	110480408
Drug ineffective for unapproved indication	33.00	9.97	18	82986	102820	110403475
Musculoskeletal pain	32.99	9.97	54	82950	182969	110323326
Respiratory tract malformation	32.91	9.97	9	82995	106	110506189
Hypokalaemia	32.80	9.97	242	82762	182206	110324089
Clostridium difficile colitis	32.56	9.97	89	82915	43689	110462606
Myelosuppression	32.55	9.97	15	82989	94325	110411970
Premature delivery	32.06	9.97	71	82933	30561	110475734
Hypovolaemia	32.01	9.97	58	82946	21616	110484679
Dry mouth	31.57	9.97	64	82940	199884	110306411
Haemoptysis	31.21	9.97	121	82883	71233	110435062
C-reactive protein increased	30.92	9.97	74	82930	217845	110288450
Pre-eclampsia	30.46	9.97	35	82969	8615	110497680
Exposure via breast milk	30.28	9.97	15	82989	1013	110505282
Haemorrhoids	30.08	9.97	76	82928	35596	110470699
Cellulitis	29.81	9.97	179	82825	125837	110380458
Peripheral venous disease	29.61	9.97	13	82991	84104	110422191
International normalised ratio increased	29.30	9.97	136	82868	86636	110419659
Haematochezia	29.21	9.97	167	82837	115357	110390938
Product dose omission issue	29.02	9.97	369	82635	321413	110184882
Essential thrombocythaemia	28.70	9.97	11	82993	397	110505898
Full blood count abnormal	28.67	9.97	100	82904	55952	110450343
Pneumonia	28.49	9.97	860	82144	875854	109630441
Product use issue	28.22	9.97	129	82875	311566	110194729
Sopor	27.88	9.97	75	82929	36471	110469824
Atrial fibrillation	27.80	9.97	279	82725	229363	110276932
Pulmonary oedema	27.78	9.97	149	82855	100510	110405785
Hypomagnesaemia	27.74	9.97	104	82900	60266	110446029
Sepsis	27.68	9.97	371	82633	326975	110179320
Fluid retention	27.68	9.97	142	82862	94165	110412130
Gastrointestinal angiodysplasia	27.65	9.97	15	82989	1223	110505072
Hospice care	27.46	9.97	40	82964	12433	110493862
Syncope	27.45	9.97	252	82752	202284	110304011
Lymph node calcification	27.22	9.97	11	82993	458	110505837
Obesity	27.11	9.97	27	82977	113324	110392971
Nasopharyngitis	27.05	9.97	179	82825	394182	110112113
Lower respiratory tract infection	26.84	9.97	93	82911	243013	110263282
Night sweats	26.59	9.97	37	82967	133946	110372349
Hypercholesterolaemia	26.22	9.97	18	82986	90819	110415476
Haemorrhage	26.17	9.97	153	82851	106539	110399756
Infection	26.06	9.97	162	82842	362038	110144257
Prescribed overdose	25.76	9.97	17	82987	87564	110418731
Therapy interrupted	25.58	9.97	89	82915	49733	110456562
Lethargy	25.47	9.97	138	82866	93438	110412857
Blood iron decreased	25.36	9.97	49	82955	19165	110487130
Chronic obstructive pulmonary disease	25.15	9.97	154	82850	109004	110397291
Red blood cell sedimentation rate increased	24.70	9.97	14	82990	78288	110428007
Respiratory failure	24.35	9.97	258	82746	215074	110291221
Swelling	24.24	9.97	159	82845	350882	110155413
Intentional product use issue	24.02	9.97	100	82904	247806	110258489
Blood creatinine increased	24.00	9.97	226	82778	182663	110323632
Small intestinal obstruction	23.47	9.97	65	82939	32148	110474147
Cytomegalovirus infection	23.36	9.97	6	82998	54438	110451857
Haematocrit decreased	23.34	9.97	105	82899	66012	110440283
Sinusitis	23.31	9.97	129	82875	296559	110209736
Heavy menstrual bleeding	23.17	9.97	43	82961	16322	110489973
Transferrin saturation increased	22.90	9.97	8	82996	221	110506074
Sinus node dysfunction	22.87	9.97	31	82973	9016	110497279
Poor sucking reflex	22.65	9.97	7	82997	130	110506165
Drug dependence	22.47	9.97	5	82999	50015	110456280
Product use in unapproved indication	22.42	9.97	221	82783	447156	110059139
Secretion discharge	22.41	9.97	48	82956	20196	110486099
Transferrin increased	22.04	9.97	5	82999	25	110506270
Metabolic alkalosis	22.04	9.97	24	82980	5571	110500724
Blood iron increased	22.00	9.97	16	82988	2182	110504113
Sinus polyp degeneration	21.99	9.97	6	82998	70	110506225
Nail disorder	21.95	9.97	8	82996	57927	110448368
Wound infection	21.92	9.97	24	82980	96441	110409854
Insurance issue	21.88	9.97	33	82971	10579	110495716
Stillbirth	21.71	9.97	21	82983	4243	110502052
COVID-19	21.65	9.97	280	82724	244780	110261515
Migraine	21.52	9.97	62	82942	171590	110334705
Transfusion-associated dyspnoea	21.26	9.97	6	82998	80	110506215
Epistaxis	21.23	9.97	169	82835	130203	110376092
Hip fracture	20.91	9.97	66	82938	35085	110471210
Nocturia	20.82	9.97	42	82962	16948	110489347
Hepatic encephalopathy	20.57	9.97	57	82947	28199	110478096
Epilepsy	20.57	9.97	27	82977	100182	110406113
Injection site reaction	20.41	9.97	22	82982	89048	110417247
Hyperlactacidaemia	20.35	9.97	28	82976	8258	110498037
Product administration interrupted	20.34	9.97	33	82971	11259	110495036
Hypothermia	20.09	9.97	54	82950	26248	110480047
Off label use	19.96	9.97	922	82082	1499263	109007032
Pain	19.71	9.97	556	82448	954399	109551896
Renal failure	19.64	9.97	258	82746	226316	110279979
Therapy non-responder	19.58	9.97	57	82947	157250	110349045
Fibrin D dimer increased	19.43	9.97	30	82974	9815	110496480
Foreign body aspiration	19.39	9.97	9	82995	526	110505769
Fibroma	18.96	9.97	11	82993	1021	110505274
Glucocorticoids increased	18.90	9.97	6	82998	122	110506173
Osteoarthritis	18.74	9.97	72	82932	182551	110323744
Vaginal haemorrhage	18.67	9.97	51	82953	25023	110481272
Varices oesophageal	18.66	9.97	25	82979	7190	110499105
Flight of ideas	18.54	9.97	10	82994	806	110505489
Pancreatic duct stenosis	18.50	9.97	7	82997	244	110506051
Abdominal pain	18.48	9.97	510	82494	512479	109993816
Neglect of personal appearance	18.30	9.97	8	82996	406	110505889
Rectal haemorrhage	18.25	9.97	153	82851	119680	110386615
Intentional product misuse	18.16	9.97	46	82958	132858	110373437
Maternal exposure during breast feeding	18.14	9.97	19	82985	4219	110502076
Pancreatic calcification	17.97	9.97	7	82997	264	110506031
Lower limb fracture	17.96	9.97	18	82986	75330	110430965
Rash	17.70	9.97	475	82529	820489	109685806
Mucosal inflammation	17.66	9.97	28	82976	96113	110410182
Drug-induced liver injury	17.64	9.97	40	82964	120027	110386268
Implant site inflammation	17.54	9.97	7	82997	282	110506013
Gastrointestinal disorder	17.51	9.97	108	82896	241844	110264451
Infective pulmonary exacerbation of cystic fibrosis	17.49	9.97	36	82968	14735	110491560
Type 2 diabetes mellitus	17.47	9.97	71	82933	177161	110329134
Discharge	17.46	9.97	14	82990	2208	110504087
Gastric antral vascular ectasia	17.45	9.97	11	82993	1186	110505109
Lactation disorder	17.37	9.97	7	82997	289	110506006
Gastritis	17.27	9.97	83	82921	53616	110452679
Postpartum haemorrhage	17.22	9.97	13	82991	1876	110504419
Uterine leiomyoma	17.15	9.97	25	82979	7775	110498520
Portal hypertensive gastropathy	17.11	9.97	13	82991	1895	110504400
Haemoglobin abnormal	17.08	9.97	27	82977	9011	110497284
Respiratory distress	17.04	9.97	99	82905	68775	110437520
Acidosis	16.95	9.97	46	82958	22485	110483810
Maternal condition affecting foetus	16.52	9.97	6	82998	186	110506109
Exostosis	16.33	9.97	7	82997	45949	110460346
Hypothyroidism	16.26	9.97	102	82902	72797	110433498
Oesophagitis	16.25	9.97	53	82951	28662	110477633
Tubulointerstitial nephritis	16.11	9.97	82	82922	54202	110452093
Pericardial effusion	15.99	9.97	85	82919	57132	110449163
Glomerular filtration rate decreased	15.99	9.97	53	82951	28903	110477392
Back injury	15.64	9.97	8	82996	47391	110458904
Ischaemic gastritis	15.50	9.97	4	83000	37	110506258
Foetal death	15.47	9.97	36	82968	16009	110490286
Serotonin syndrome	15.44	9.97	13	82991	59140	110447155
Haematuria	15.42	9.97	111	82893	82894	110423401
Peritonitis bacterial	15.32	9.97	28	82976	10505	110495790
Pancreatic mass	15.24	9.97	12	82992	1843	110504452
Inability to afford medication	15.22	9.97	17	82987	4059	110502236
Bradycardia	15.15	9.97	181	82823	155336	110350959
Blood creatine phosphokinase MM increased	15.13	9.97	4	83000	41	110506254
Blood pressure abnormal	15.12	9.97	44	82960	22380	110483915
Thermohypoaesthesia	15.09	9.97	5	82999	117	110506178
Drug eruption	15.00	9.97	11	82993	53648	110452647
Cortical visual impairment	14.88	9.97	4	83000	44	110506251
Non-cardiogenic pulmonary oedema	14.53	9.97	12	82992	1972	110504323
Benign soft tissue neoplasm	14.52	9.97	5	82999	132	110506163
Gait inability	14.49	9.97	53	82951	136323	110369972
Blepharospasm	14.38	9.97	12	82992	54839	110451456
Urine output decreased	14.37	9.97	40	82964	19836	110486459
Hyperglycaemia	14.23	9.97	111	82893	84979	110421316
Inflammatory bowel disease	14.21	9.97	22	82982	7212	110499083
Constipation	14.11	9.97	360	82644	357426	110148869
Autoimmune haemolytic anaemia	14.01	9.97	27	82977	10540	110495755
Meconium in amniotic fluid	13.83	9.97	5	82999	153	110506142
Regurgitation	13.81	9.97	15	82989	3470	110502825
Abnormal cord insertion	13.77	9.97	3	83001	12	110506283
Failure to thrive	13.69	9.97	31	82973	13543	110492752
Internal haemorrhage	13.68	9.97	26	82978	10045	110496250
Oesophageal injury	13.68	9.97	6	82998	307	110505988
Azotaemia	13.66	9.97	26	82978	10059	110496236
Oedema peripheral	13.64	9.97	333	82671	328327	110177968
Onychomycosis	13.49	9.97	6	82998	38525	110467770
Haemorrhagic erosive gastritis	13.49	9.97	8	82996	774	110505521
Internal fixation of fracture	13.44	9.97	7	82997	526	110505769
Incorrect route of product administration	13.41	9.97	17	82987	64044	110442251
Lip swelling	13.30	9.97	74	82930	50593	110455702
Gestational hypertension	13.29	9.97	12	82992	2222	110504073
Coeliac disease	13.23	9.97	8	82996	43179	110463116
Carbuncle	13.17	9.97	10	82994	1457	110504838
Complication associated with device	13.16	9.97	39	82965	20034	110486261
Coma	13.06	9.97	45	82959	117824	110388471
Hiatus hernia	13.05	9.97	48	82956	27558	110478737
Mental impairment	13.00	9.97	42	82962	22597	110483698
Wrong patient	12.97	9.97	10	82994	1489	110504806
Poisoning	12.89	9.97	3	83001	29102	110477193
Haemosiderosis	12.83	9.97	7	82997	577	110505718
Laryngitis	12.79	9.97	8	82996	42403	110463892
Cardiac hypertrophy	12.67	9.97	11	82993	1936	110504359
Troponin increased	12.63	9.97	50	82954	29716	110476579
Illness	12.56	9.97	105	82899	82066	110424229
Haematoma	12.53	9.97	81	82923	58395	110447900
Vitamin B12 deficiency	12.49	9.97	25	82979	10030	110496265
Capillaritis	12.39	9.97	12	82992	2427	110503868
Hypermagnesaemia	12.27	9.97	10	82994	1613	110504682
Iron deficiency	12.21	9.97	36	82968	18440	110487855
Chronic hepatic failure	12.15	9.97	9	82995	1262	110505033
Unwanted awareness during anaesthesia	12.14	9.97	6	82998	403	110505892
Sight disability	12.13	9.97	5	82999	219	110506076
Asocial behaviour	12.10	9.97	4	83000	93	110506202
Renal cyst ruptured	12.10	9.97	4	83000	93	110506202
Hydrocele	12.09	9.97	9	82995	1272	110505023
Uterine haemorrhage	12.07	9.97	14	82990	3480	110502815
Hypoosmolar state	12.01	9.97	6	82998	413	110505882
Blood chloride increased	11.99	9.97	19	82985	6353	110499942
Therapeutic response decreased	11.98	9.97	35	82969	96464	110409831
Wheezing	11.98	9.97	128	82876	255102	110251193
Antipsychotic drug level increased	11.96	9.97	20	82984	6995	110499300
Prescribed underdose	11.95	9.97	19	82985	65155	110441140
Road traffic accident	11.90	9.97	41	82963	107357	110398938
Blood prolactin increased	11.88	9.97	16	82988	4626	110501669
Knee arthroplasty	11.85	9.97	19	82985	64929	110441366
Abdominal distension	11.85	9.97	191	82813	174912	110331383
Colon cancer	11.80	9.97	33	82971	16410	110489885
Normocytic anaemia	11.78	9.97	19	82985	6448	110499847
Lung consolidation	11.78	9.97	25	82979	10451	110495844
Drug resistance	11.76	9.97	15	82989	56359	110449936
Brain natriuretic peptide increased	11.75	9.97	26	82978	11183	110495112
Unresponsive to stimuli	11.68	9.97	85	82919	63705	110442590
Eosinophilia	11.66	9.97	79	82925	57857	110448438
Productive cough	11.56	9.97	134	82870	114171	110392124
Pyuria	11.51	9.97	12	82992	2651	110503644
Hip arthroplasty	11.49	9.97	15	82989	55798	110450497
Cardiac disorder	11.40	9.97	97	82907	76183	110430112
Mitral valve stenosis	11.37	9.97	9	82995	1393	110504902
Adverse reaction	11.36	9.97	4	83000	29590	110476705
Full blood count decreased	11.34	9.97	51	82953	32048	110474247
Nasal congestion	11.21	9.97	118	82886	98164	110408131
Crystal urine	11.20	9.97	4	83000	118	110506177
Sciatica	11.12	9.97	34	82970	92365	110413930
Blood urea increased	11.10	9.97	75	82929	54882	110451413
Balance disorder	11.06	9.97	135	82869	116425	110389870
Meningism	11.05	9.97	7	82997	762	110505533
Foetal exposure during pregnancy	10.98	9.97	20	82984	7485	110498810
Device dislocation	10.93	9.97	50	82954	31654	110474641
Dialysis	10.91	9.97	36	82968	19583	110486712
Influenza	10.90	9.97	183	82821	168918	110337377
Ludwig angina	10.89	9.97	5	82999	285	110506010
Pancreatitis	10.85	9.97	35	82969	93498	110412797
Chronic respiratory failure	10.83	9.97	14	82990	3889	110502406
Angiodysplasia	10.82	9.97	9	82995	1493	110504802
Large intestinal obstruction	10.82	9.97	14	82990	3894	110502401
Administration site warmth	10.77	9.97	3	83001	38	110506257
Oxygen consumption increased	10.77	9.97	17	82987	5668	110500627
Polyhydramnios	10.76	9.97	10	82994	1923	110504372
Renal arteriosclerosis	10.74	9.97	6	82998	518	110505777
Intracardiac mass	10.71	9.97	5	82999	296	110505999
Arteriovenous malformation	10.68	9.97	10	82994	1941	110504354
Oxygen saturation decreased	10.53	9.97	171	82833	156811	110349484
Pancreatic injury	10.45	9.97	5	82999	313	110505982
Premature labour	10.45	9.97	22	82982	9150	110497145
Essential hypertension	10.34	9.97	20	82984	7827	110498468
Gastric ulcer	10.34	9.97	58	82946	39769	110466526
Walking aid user	10.31	9.97	3	83001	25072	110481223
Pleural effusion	10.27	9.97	189	82815	177520	110328775
Gastric varices	10.19	9.97	7	82997	872	110505423
Monoclonal immunoglobulin present	10.19	9.97	11	82993	2529	110503766
Disability	10.13	9.97	5	82999	30218	110476077
Acute hepatic failure	10.07	9.97	54	82950	36414	110469881
Hyperdynamic left ventricle	10.06	9.97	6	82998	586	110505709
Tricuspid valve incompetence	10.04	9.97	40	82964	23833	110482462
Infected neoplasm	10.03	9.97	6	82998	589	110505706

FDA Adverse Event Reporting System (Pediatric)

None

Pharmacologic Action:

Source	Code	Description
ATC	B03AA07	BLOOD AND BLOOD FORMING ORGANS ANTIANEMIC PREPARATIONS IRON PREPARATIONS Iron bivalent, oral preparations
ATC	B03AD03	BLOOD AND BLOOD FORMING ORGANS ANTIANEMIC PREPARATIONS IRON PREPARATIONS Iron in combination with folic acid
CHEBI has role	CHEBI:35554	cardiovascular drug
CHEBI has role	CHEBI:50247	antidote
CHEBI has role	CHEBI:75835	anti-anaemic agent

Related Drugs by ATC class:

B03AA Iron bivalent, oral preparations 8 drugs

ferrous ascorbateferrous aspartateferrous carbonateferrous chlorideferrous fumarateferrous gluconateferrous succinateferrous tartrate

B03AD Iron in combination with folic acid 3 drugs

ferrous fumarateferrous gluconatefolic acid

Drug Use | Suggest Off label Use Form| |View source of the data|

Disease	Relation	SNOMED_ID	DOID
Anemia of prematurity	indication	47100003	DOID:11243
Megaloblastic anemia due to folate deficiency	indication	85649008	DOID:14026
Vitamin deficiency	indication	85670002
Iron deficiency anemia	indication	87522002
Mineral deficiency	indication	111379007
Mineral Deficiency Prevention	indication
Vitamin Deficiency Prevention	indication
Peptic ulcer	contraindication	13200003	DOID:750
Operation on stomach	contraindication	16453004
Primary hyperoxaluria	contraindication	17901006	DOID:2977
Gastroenteritis	contraindication	25374005	DOID:2326
Hemosiderosis	contraindication	39011001	DOID:12119
Hemolytic anemia	contraindication	61261009	DOID:583
Ulcerative colitis	contraindication	64766004	DOID:8577
Anemia due to enzyme deficiency	contraindication	111577008
Hb SS disease	contraindication	127040003	DOID:10923
Esophageal dysmotility	contraindication	266434009	DOID:9192
Diverticular disease	contraindication	397881000
Hemochromatosis	contraindication	399187006	DOID:2352
Repeated Blood Transfusions	contraindication

🐶 Veterinary Drug Use

None

🐶 Veterinary products

None

Acid dissociation constants calculated using MoKa v3.0.0

None

Orange Book patent data (new drug applications)

None

Orange Book exclusivity data (new drug applications)

None

Bioactivity Summary:

None

External reference:

ID	Source
D04172	KEGG_DRUG
4017707	VUID
N0000146077	NUI
7782-63-0	SECONDARY_CAS_RN
4017662	VANDF
4017664	VANDF
4017707	VANDF
CHEBI:75832	CHEBI
CHEMBL1200830	ChEMBL_ID
C020748	MESH_SUPPLEMENTAL_RECORD_UI
39R4TAN1VT	UNII
24947	RXNORM
4725	MMSL
4920	MMSL
6168	MMSL
63844	MMSL
d03824	MMSL
000840	NDDF
007813	NDDF
387402000	SNOMEDCT_US
71724000	SNOMEDCT_US
C0060282	UMLSCUI
24393	PUBCHEM_CID

Pharmaceutical products:

Product	Category	Ingredients	NDC	Form	Quantity	Route	Marketing	Label
Quflora FE Pediatric Drops	HUMAN PRESCRIPTION DRUG LABEL	14	15370-102	LIQUID	9.50 mg	ORAL	UNAPPROVED DRUG OTHER	11 sections
FERROUS SULFATE	HUMAN OTC DRUG LABEL	1	50436-5890	TABLET	325 mg	ORAL	Unapproved drug other	10 sections
FERROUS SULFATE	HUMAN OTC DRUG LABEL	1	53807-177	ELIXIR	220 mg	ORAL	UNAPPROVED DRUG OTHER	15 sections
FERROUS SULFATE	HUMAN OTC DRUG LABEL	1	53808-0918	TABLET	325 mg	ORAL	UNAPPROVED DRUG OTHER	10 sections
Ferrous Sulfate	HUMAN OTC DRUG LABEL	1	54738-963	TABLET	325 mg	ORAL	unapproved drug other	11 sections
Ferrous Sulfate	HUMAN OTC DRUG LABEL	1	54738-963	TABLET	325 mg	ORAL	unapproved drug other	11 sections
FERROUS SULFATE	HUMAN OTC DRUG LABEL	2	58607-113	TABLET	65 mg	ORAL	unapproved drug other	9 sections
Multi-Vitamin Drops with Fluoride and Iron	HUMAN PRESCRIPTION DRUG LABEL	10	58657-327	LIQUID	10 mg	ORAL	unapproved drug other	10 sections
Multi-Vitamin Drops with Fluoride and Iron	HUMAN PRESCRIPTION DRUG LABEL	10	58657-327	LIQUID	10 mg	ORAL	unapproved drug other	10 sections
Ferrous Sulfate	HUMAN OTC DRUG LABEL	1	67296-1555	TABLET, FILM COATED	325 mg	ORAL	unapproved drug other	10 sections
Ferrous Sulfate	Human OTC Drug Label	1	76413-308	TABLET, FILM COATED	325 mg	ORAL	UNAPPROVED DRUG OTHER	10 sections
Ferrous Sulfate	Human OTC Drug Label	1	76413-356	TABLET, FILM COATED	325 mg	ORAL	UNAPPROVED DRUG OTHER	11 sections