All FDA-approved EMA-approved PMDA-approved
Target Card Uniprot Example: P23975

ferrous sulfate 🐶 Veterinary Use | Indications/Contra | FAERs-F | FAERs-M | Orange Bk | BioActivity |

Stem definition	Drug id	CAS RN
	4528	7720-78-7

Description:

Molecule	Description
Synonyms: ferrous sulfate ferrous sulfate, dried	Ferro-Gradumet is ferrous sulfate in controlled release form; RN given refers to Fe(+2)[1:1] salt Molecular weight: 151.90 Formula: FeO4S CLOGP: LIPINSKI: None HAC: None HDO: None TPSA: 80.26 ALOGS: ROTB: None

Drug dosage:

Dose	Unit	Route
0.20	g	O

ADMET properties:

Property	Value	Reference
BDDCS (Biopharmaceutical Drug Disposition Classification System)	3	Benet LZ, Broccatelli F, Oprea TI
S (Water solubility)	570 mg/mL	Benet LZ, Broccatelli F, Oprea TI
MRTD (Maximum Recommended Therapeutic Daily Dose)	30.56 µM/kg/day	Contrera JF, Matthews EJ, Kruhlak NL, Benz RD

Approvals:

Date	Agency	Company	Orphan
Aug. 13, 1946	FDA	LEDERLE

FDA Adverse Event Reporting System (Female)

MedDRA adverse event term	Likelihood ratio	Likelihood ratio threshold	Patients taking drug having adverse event	Patients taking drug not having adverse event	Patients not taking drug having adverse event	Patients not taking drug not having adverse event
Drug ineffective	184.81	10.23	254	42400	819079	49743391
Acute kidney injury	130.95	10.23	456	42198	227602	50334868
Anaemia	114.42	10.23	468	42186	251988	50310482
Drug intolerance	85.28	10.23	39	42615	219065	50343405
Hypervolaemia	81.55	10.23	104	42550	25395	50537075
Contraindicated product administered	80.99	10.23	14	42640	148944	50413526
Treatment failure	76.91	10.23	12	42642	137625	50424845
Hand deformity	71.52	10.23	3	42651	100196	50462274
Completed suicide	70.38	10.23	13	42641	131876	50430594
Haemoglobin decreased	69.09	10.23	250	42404	126966	50435504
Systemic lupus erythematosus	68.64	10.23	17	42637	140605	50421865
Glossodynia	64.74	10.23	10	42644	115559	50446911
Rheumatoid arthritis	58.27	10.23	51	42603	202499	50359971
Hepatic enzyme increased	57.36	10.23	22	42632	137358	50425112
Joint swelling	52.91	10.23	78	42576	245208	50317262
Pulmonary malformation	51.99	10.23	15	42639	192	50562278
Arthropathy	51.46	10.23	35	42619	157871	50404599
Gastrointestinal haemorrhage	48.51	10.23	154	42500	73167	50489303
Alopecia	48.06	10.23	83	42571	244964	50317506
Discomfort	47.54	10.23	16	42638	108364	50454106
Pulmonary hypertension	47.50	10.23	94	42560	33323	50529147
Melaena	47.50	10.23	83	42571	26781	50535689
Therapeutic product effect decreased	47.29	10.23	28	42626	136022	50426448
Pulmonary arterial hypertension	45.71	10.23	70	42584	20249	50542221
Drug hypersensitivity	45.68	10.23	89	42565	250921	50311549
Premature delivery	45.65	10.23	76	42578	23587	50538883
Pericarditis	43.63	10.23	7	42647	78682	50483788
Hyperkalaemia	41.41	10.23	111	42543	47978	50514492
Hospitalisation	40.73	10.23	138	42516	67799	50494671
Cardiac failure acute	38.71	10.23	41	42613	8209	50554261
Lung cyst	36.64	10.23	11	42643	163	50562307
Iron deficiency anaemia	36.47	10.23	57	42597	16777	50545693
Wound	36.44	10.23	22	42632	105772	50456698
Abdominal discomfort	35.68	10.23	90	42564	231551	50330919
Right ventricular failure	34.69	10.23	54	42600	15839	50546631
Metabolic alkalosis	34.57	10.23	24	42630	2707	50559763
Hypoxia	34.37	10.23	108	42546	51015	50511455
Hypersensitivity	32.82	10.23	84	42570	215077	50347393
Arthralgia	32.75	10.23	226	42428	438476	50123994
Transfusion	32.68	10.23	47	42607	12858	50549612
Congenital ovarian anomaly	32.32	10.23	6	42648	6	50562464
Musculoskeletal stiffness	31.62	10.23	37	42617	128444	50434026
Helicobacter infection	31.00	10.23	3	42651	49699	50512771
Infusion related reaction	30.92	10.23	60	42594	169497	50392973
Pain	30.78	10.23	326	42328	578577	49983893
Pneumonia	30.66	10.23	468	42186	377933	50184537
Acute respiratory failure	30.61	10.23	72	42582	28710	50533760
Urinary tract infection	30.23	10.23	305	42349	223715	50338755
Faeces discoloured	30.05	10.23	51	42603	16073	50546397
Transferrin saturation increased	29.88	10.23	7	42647	36	50562434
Metabolic acidosis	29.85	10.23	86	42568	38739	50523731
Autoimmune haemolytic anaemia	28.47	10.23	25	42629	3974	50558496
Congenital skin dimples	26.94	10.23	8	42646	114	50562356
Gastrointestinal tract mucosal pigmentation	26.82	10.23	12	42642	572	50561898
Cardiac failure congestive	26.67	10.23	141	42513	84241	50478229
Foetal exposure during pregnancy	26.48	10.23	66	42588	27293	50535177
Transferrin increased	26.46	10.23	5	42649	6	50562464
Death	25.79	10.23	401	42253	324978	50237492
Lactic acidosis	24.79	10.23	73	42581	33282	50529188
Dyspnoea exertional	24.72	10.23	97	42557	51136	50511334
Toxicity to various agents	24.59	10.23	94	42560	212405	50350065
Respiratory tract malformation	24.23	10.23	7	42647	90	50562380
Product use issue	23.84	10.23	57	42597	149418	50413052
Dyspnoea	23.35	10.23	615	42039	546993	50015477
Hypotension	22.95	10.23	301	42353	235168	50327302
Fluid retention	22.92	10.23	94	42560	50555	50511915
Maternal exposure during breast feeding	22.48	10.23	20	42634	3234	50559236
Exposure via breast milk	22.42	10.23	15	42639	1593	50560877
Impaired healing	22.01	10.23	16	42638	69770	50492700
Gingival hypertrophy	21.94	10.23	14	42640	1372	50561098
Blood loss anaemia	21.13	10.23	30	42624	8109	50554361
Therapeutic product effect incomplete	20.79	10.23	28	42626	91487	50470983
General physical health deterioration	20.64	10.23	57	42597	142377	50420093
Folliculitis	20.62	10.23	4	42650	39221	50523249
Oesophageal injury	20.42	10.23	5	42649	32	50562438
Haemoptysis	20.00	10.23	57	42597	25516	50536954
Pre-eclampsia	19.93	10.23	29	42625	8015	50554455
Hypoosmolar state	19.86	10.23	7	42647	176	50562294
Hypothermia	19.79	10.23	36	42618	11980	50550490
Diastasis recti abdominis	19.79	10.23	5	42649	37	50562433
Fall	19.46	10.23	393	42261	334539	50227931
Blood iron decreased	19.39	10.23	35	42619	11580	50550890
Hypoglycaemia	19.37	10.23	93	42561	53488	50508982
Hepatic encephalopathy	18.65	10.23	31	42623	9605	50552865
Diarrhoea	18.61	10.23	637	42017	587839	49974631
Sight disability	18.50	10.23	6	42648	116	50562354
Thermohypoaesthesia	18.45	10.23	6	42648	117	50562353
Renal arteriosclerosis	18.36	10.23	5	42649	51	50562419
Foetal death	18.14	10.23	28	42626	8152	50554318
Glucocorticoids increased	18.04	10.23	6	42648	126	50562344
Mobility decreased	17.62	10.23	25	42629	79923	50482547
Drug abuse	17.27	10.23	15	42639	59831	50502639
Asthenia	17.11	10.23	370	42284	318672	50243798
Cellulitis	16.98	10.23	110	42544	70688	50491782
Sepsis	16.96	10.23	179	42475	132746	50429724
Discharge	16.96	10.23	10	42644	851	50561619
Haemorrhagic erosive gastritis	16.92	10.23	7	42647	275	50562195
Haematochezia	16.47	10.23	72	42582	39810	50522660
Cardiac failure	16.35	10.23	115	42539	75925	50486545
Epistaxis	16.35	10.23	101	42553	63853	50498617
Sopor	16.22	10.23	45	42609	19834	50542636
Hypokalaemia	16.05	10.23	128	42526	87864	50474606
Renal tubular acidosis	16.03	10.23	12	42642	1522	50560948
Hyponatraemia	16.01	10.23	137	42517	96002	50466468
Chronic obstructive pulmonary disease	16.00	10.23	88	42566	53347	50509123
Chronic kidney disease	15.82	10.23	71	42583	39700	50522770
Lactation disorder	15.78	10.23	7	42647	327	50562143
Internal haemorrhage	15.69	10.23	19	42635	4398	50558072
Foetal malnutrition	15.45	10.23	5	42649	96	50562374
Mental status changes	15.38	10.23	66	42588	36206	50526264
Constipation	15.11	10.23	230	42424	185478	50376992
Haematocrit decreased	15.10	10.23	64	42590	34912	50527558
Infected neoplasm	14.97	10.23	6	42648	217	50562253
Blood creatine phosphokinase MM increased	14.95	10.23	4	42650	38	50562432
N-terminal prohormone brain natriuretic peptide increased	14.88	10.23	12	42642	1698	50560772
Genital prolapse	14.76	10.23	4	42650	40	50562430
Rectal haemorrhage	14.72	10.23	68	42586	38490	50523980
Infective pulmonary exacerbation of cystic fibrosis	14.72	10.23	25	42629	7884	50554586
Respiratory failure	14.70	10.23	129	42525	91052	50471418
Congenital cystic lung	14.58	10.23	4	42650	42	50562428
Troponin increased	14.24	10.23	25	42629	8093	50554377
Hypermagnesaemia	14.08	10.23	9	42645	885	50561585
Sinus node dysfunction	14.03	10.23	17	42637	3938	50558532
Abdominal pain	13.97	10.23	278	42376	235950	50326520
Periodontitis	13.95	10.23	15	42639	3054	50559416
Haematemesis	13.78	10.23	53	42601	27672	50534798
Arteriovenous malformation	13.50	10.23	10	42644	1248	50561222
Therapeutic response decreased	13.43	10.23	12	42642	47219	50515251
Psoriatic arthropathy	13.31	10.23	12	42642	47020	50515450
Urticaria	13.30	10.23	60	42594	129501	50432969
Blister	13.27	10.23	33	42621	85385	50477085
Product dose omission issue	13.19	10.23	223	42431	183615	50378855
Ketosis	12.80	10.23	7	42647	516	50561954
Hypovolaemia	12.70	10.23	26	42628	9439	50553031
Threatened labour	12.58	10.23	8	42646	779	50561691
Maternal condition affecting foetus	12.57	10.23	5	42649	177	50562293
Regressive behaviour	12.40	10.23	4	42650	76	50562394
Rash	12.31	10.23	278	42376	437193	50125277
Azotaemia	12.26	10.23	16	42638	3992	50558478
International normalised ratio increased	12.21	10.23	70	42584	43082	50519388
Abdominal distension	12.19	10.23	104	42550	72799	50489671
Cholestasis	12.17	10.23	48	42606	25353	50537117
Meningism	12.16	10.23	6	42648	357	50562113
Urine output decreased	12.11	10.23	27	42627	10394	50552076
Atrial fibrillation	12.04	10.23	135	42519	101610	50460860
Application site haematoma	11.90	10.23	3	42651	22	50562448
Hospice care	11.75	10.23	19	42635	5753	50556717
C-reactive protein increased	11.69	10.23	24	42630	66450	50496020
Swelling	11.49	10.23	111	42543	200761	50361709
Clostridium difficile colitis	11.48	10.23	37	42617	17705	50544765
Exposure during pregnancy	11.48	10.23	154	42500	120861	50441609
Irritable bowel syndrome	11.42	10.23	16	42638	51425	50511045
Hyponatraemic seizure	11.39	10.23	6	42648	410	50562060
Full blood count decreased	11.34	10.23	43	42611	22303	50540167
Portal hypertensive gastropathy	11.28	10.23	7	42647	653	50561817
Pulmonary oedema	11.10	10.23	75	42579	48863	50513607
Cellulitis orbital	11.10	10.23	6	42648	432	50562038
Haemoglobin abnormal	11.07	10.23	16	42638	4396	50558074
Anastomotic stenosis	11.06	10.23	5	42649	244	50562226
Umbilical discharge	11.01	10.23	4	42650	110	50562360
Syncope	11.00	10.23	134	42520	102868	50459602
Uterine leiomyoma	10.97	10.23	22	42632	7869	50554601
Angina unstable	10.93	10.23	20	42634	6686	50555784
Mixed liver injury	10.91	10.23	14	42640	3437	50559033
Sinus arrest	10.87	10.23	10	42644	1688	50560782
Hepatic cirrhosis	10.78	10.23	36	42618	17541	50544929
Haemoperitoneum	10.77	10.23	12	42642	2543	50559927
Lethargy	10.77	10.23	75	42579	49357	50513113
Optic ischaemic neuropathy	10.73	10.23	8	42646	1009	50561461
Injection site reaction	10.67	10.23	16	42638	50016	50512454
Oedema	10.64	10.23	98	42556	70083	50492387
Oxygen consumption increased	10.64	10.23	14	42640	3522	50558948
Chronic hepatic failure	10.57	10.23	6	42648	475	50561995
Unwanted awareness during anaesthesia	10.42	10.23	5	42649	280	50562190
Total bile acids increased	10.38	10.23	4	42650	130	50562340
Accidental overdose	10.25	10.23	38	42616	19495	50542975

FDA Adverse Event Reporting System (Male)

MedDRA adverse event term	Likelihood ratio	Likelihood ratio threshold	Patients taking drug having adverse event	Patients taking drug not having adverse event	Patients not taking drug having adverse event	Patients not taking drug not having adverse event
Acute kidney injury	67.58	11.83	391	22422	264876	29286838
Drug ineffective	57.28	11.83	122	22691	363048	29188666
Completed suicide	51.54	11.83	5	22808	90241	29461473
Hyperkalaemia	47.78	11.83	129	22684	61263	29490451
Foetal disorder	47.14	11.83	19	22794	764	29550950
Faeces discoloured	45.82	11.83	54	22759	13297	29538417
Encephalitis toxic	44.28	11.83	14	22799	273	29551441
Foetal exposure during pregnancy	42.67	11.83	86	22727	33781	29517933
Anaemia	40.33	11.83	279	22534	200672	29351042
Periodontitis	39.99	11.83	22	22791	1795	29549919
Neutropenia neonatal	39.75	11.83	16	22797	641	29551073
Lymph node calcification	39.22	11.83	11	22802	139	29551575
Hospitalisation	37.14	11.83	98	22715	45890	29505824
Drug abuse	35.37	11.83	9	22804	79874	29471840
Premature baby	34.91	11.83	54	22759	17226	29534488
Cardiac dysfunction	34.67	11.83	20	22793	1787	29549927
Gastrointestinal haemorrhage	32.15	11.83	134	22679	79399	29472315
Hyperlactacidaemia	29.77	11.83	21	22792	2657	29549057
Asthenia	27.06	11.83	269	22544	214981	29336733
Low birth weight baby	26.53	11.83	29	22784	6579	29545135
Blood loss anaemia	24.28	11.83	29	22784	7237	29544477
Death	23.50	11.83	382	22431	341702	29210012
Gingival hypertrophy	23.16	11.83	15	22798	1650	29550064
Full blood count decreased	23.05	11.83	43	22770	15949	29535765
Febrile neutropenia	22.79	11.83	32	22781	112208	29439506
Toxicity to various agents	22.06	11.83	65	22748	173596	29378118
Fall	22.04	11.83	221	22592	176957	29374757
Haemoglobin decreased	21.39	11.83	150	22663	108225	29443489
Pancreatic duct stenosis	20.32	11.83	7	22806	180	29551534
Pancreatic calcification	20.14	11.83	7	22806	185	29551529
Iron deficiency anaemia	19.56	11.83	29	22784	8913	29542801
Implant site inflammation	19.53	11.83	6	22807	106	29551608
Gastrointestinal angiodysplasia	18.72	11.83	9	22804	554	29551160
Pancreatic mass	18.03	11.83	10	22803	829	29550885
Clostridium difficile infection	18.00	11.83	39	22774	16102	29535612
Transfusion	17.91	11.83	25	22788	7273	29544441
Urinary tract infection	17.86	11.83	106	22707	72248	29479466
Foreign body aspiration	17.39	11.83	6	22807	155	29551559
Cortical visual impairment	16.77	11.83	4	22809	25	29551689
Exposure during pregnancy	16.26	11.83	26	22787	8528	29543186
Hypervolaemia	15.83	11.83	39	22774	17506	29534208
Tubulointerstitial nephritis	15.68	11.83	39	22774	17604	29534110
Gastrointestinal tract mucosal pigmentation	15.45	11.83	7	22806	376	29551338
Feeding intolerance	15.12	11.83	5	22808	113	29551601
Hospice care	14.96	11.83	19	22794	5049	29546665
Dyspnoea	14.92	11.83	343	22470	326389	29225325
Cardiac ventricular disorder	14.84	11.83	6	22807	243	29551471
Pancreatic injury	14.80	11.83	5	22808	121	29551593
Therapeutic product effect incomplete	14.61	11.83	6	22807	39299	29512415
Enterocolitis bacterial	14.35	11.83	6	22807	265	29551449
Pericardial effusion	13.97	11.83	42	22771	21166	29530548
Therapy interrupted	13.94	11.83	24	22789	8362	29543352
Asocial behaviour	13.57	11.83	4	22809	61	29551653
Bronchial obstruction	13.40	11.83	10	22803	1381	29550333
Ventricular septal defect	13.33	11.83	15	22798	3514	29548200
Ludwig angina	13.22	11.83	5	22808	169	29551545
Suicide attempt	13.02	11.83	5	22808	34105	29517609
Flight of ideas	12.88	11.83	6	22807	344	29551370
Crystal urine	12.80	11.83	4	22809	75	29551639
Acute respiratory failure	12.69	11.83	47	22766	26355	29525359
Bronchial disorder	12.67	11.83	9	22804	1152	29550562
Radiation proctitis	12.65	11.83	4	22809	78	29551636
Lip blister	12.53	11.83	7	22806	588	29551126
Bone marrow failure	12.32	11.83	3	22810	27446	29524268

FDA Adverse Event Reporting System (Geriatric)

MedDRA adverse event term	Likelihood ratio	Likelihood ratio threshold	Patients taking drug having adverse event	Patients taking drug not having adverse event	Patients not taking drug having adverse event	Patients not taking drug not having adverse event
Acute kidney injury	186.19	10.04	820	54519	448420	63994973
Drug ineffective	163.08	10.04	296	55043	839951	63603442
Completed suicide	132.16	10.04	18	55321	224396	64218997
Anaemia	125.91	10.04	649	54690	378031	64065362
Hypervolaemia	94.47	10.04	139	55200	38146	64405247
Hyperkalaemia	84.12	10.04	233	55106	100896	64342497
Drug intolerance	80.99	10.04	30	55309	187962	64255431
Gastrointestinal haemorrhage	80.30	10.04	273	55066	132039	64311354
Haemoglobin decreased	70.77	10.04	343	54996	194720	64248673
Faeces discoloured	68.71	10.04	97	55242	25632	64417761
Toxicity to various agents	61.64	10.04	138	55201	363375	64080018
Hospitalisation	55.48	10.04	166	55173	75041	64368352
Drug abuse	53.92	10.04	23	55316	132351	64311042
Treatment failure	53.13	10.04	17	55322	116799	64326594
Periodontitis	53.11	10.04	37	55302	4122	64439271
Contraindicated product administered	50.28	10.04	15	55324	107814	64335579
Pulmonary arterial hypertension	48.57	10.04	82	55257	25285	64418108
Pulmonary hypertension	46.88	10.04	110	55229	43029	64400364
Transfusion	46.81	10.04	67	55272	17927	64425466
Gingival hypertrophy	46.15	10.04	29	55310	2718	64440675
Joint swelling	45.04	10.04	72	55267	215310	64228083
Drug hypersensitivity	43.87	10.04	86	55253	237729	64205664
Iron deficiency anaemia	43.56	10.04	72	55267	21817	64421576
Hepatic enzyme increased	43.50	10.04	29	55310	129914	64313479
Dyspnoea	42.93	10.04	859	54480	717815	63725578
Pulmonary malformation	42.71	10.04	12	55327	136	64443257
Melaena	42.17	10.04	121	55218	53427	64389966
Gastrointestinal tract mucosal pigmentation	42.09	10.04	19	55320	908	64442485
Encephalitis toxic	38.63	10.04	13	55326	278	64443115
Death	38.39	10.04	604	54735	482101	63961292
Cardiac failure acute	38.39	10.04	58	55281	16286	64427107
Blood loss anaemia	38.02	10.04	53	55286	13839	64429554
Hypoxia	37.87	10.04	163	55176	87986	64355407
Acute respiratory failure	36.61	10.04	110	55229	49824	64393569
Rheumatoid arthritis	34.27	10.04	55	55284	164239	64279154
Fall	34.05	10.04	524	54815	416302	64027091
Musculoskeletal stiffness	33.19	10.04	34	55305	123172	64320221
Arthropathy	33.02	10.04	33	55306	120934	64322459
Haematemesis	33.02	10.04	102	55237	46897	64396496
Therapeutic product effect decreased	32.03	10.04	31	55308	115320	64328073
Metabolic acidosis	31.86	10.04	133	55206	70825	64372568
Urinary tract infection	31.80	10.04	321	55018	231275	64212118
Therapeutic product effect incomplete	30.89	10.04	26	55313	103456	64339937
Systemic lupus erythematosus	30.78	10.04	14	55325	77598	64365795
Arthralgia	30.62	10.04	238	55101	442022	64001371
Lymph node calcification	29.91	10.04	11	55328	308	64443085
Right ventricular failure	29.29	10.04	60	55279	21411	64421982
Alopecia	28.77	10.04	62	55277	165628	64277765
Lung cyst	28.41	10.04	9	55330	158	64443235
Febrile neutropenia	28.02	10.04	76	55263	187581	64255812
Cardiac failure congestive	27.43	10.04	199	55140	130381	64313012
Glossodynia	26.72	10.04	11	55328	64685	64378708
Infusion related reaction	26.56	10.04	64	55275	164403	64278990
Metabolic alkalosis	26.49	10.04	24	55315	3904	64439489
Transferrin saturation increased	26.36	10.04	8	55331	121	64443272
Asthenia	26.24	10.04	514	54825	427530	64015863
Discomfort	25.80	10.04	19	55320	80859	64362534
Hyponatraemia	25.60	10.04	216	55123	148123	64295270
Dyspnoea exertional	25.51	10.04	128	55211	73602	64369791
Fluid retention	25.42	10.04	110	55229	59496	64383897
Pericarditis	25.23	10.04	11	55328	62505	64380888
Foetal death	24.84	10.04	28	55311	5902	64437491
Premature delivery	24.24	10.04	51	55288	18538	64424855
Hypotension	23.17	10.04	457	54882	380517	64062876
Chronic kidney disease	22.53	10.04	104	55235	57815	64385578
Haemoptysis	22.06	10.04	92	55247	48956	64394437
Hypothermia	21.97	10.04	51	55288	19805	64423588
Bone marrow failure	21.76	10.04	7	55332	47945	64395448
Chronic obstructive pulmonary disease	21.59	10.04	119	55220	70929	64372464
Transferrin increased	21.37	10.04	5	55334	25	64443368
Oesophageal injury	21.04	10.04	6	55333	72	64443321
Mental status changes	21.03	10.04	106	55233	61056	64382337
Lactic acidosis	20.81	10.04	106	55233	61304	64382089
Hospice care	20.73	10.04	29	55310	7596	64435797
Tubulointerstitial nephritis	20.71	10.04	66	55273	30843	64412550
Discharge	20.56	10.04	12	55327	984	64442409
Helicobacter infection	20.49	10.04	4	55335	38358	64405035
Pre-eclampsia	20.48	10.04	26	55313	6205	64437188
Cardiac failure	20.37	10.04	188	55151	132185	64311208
Drug resistance	20.20	10.04	3	55336	35099	64408294
Pneumonia	19.87	10.04	624	54715	558952	63884441
Duodenal ulcer perforation	19.84	10.04	3	55336	34622	64408771
Clostridium difficile infection	19.65	10.04	72	55267	36091	64407302
Impaired healing	19.56	10.04	14	55325	60459	64382934
Maternal exposure during breast feeding	19.13	10.04	15	55324	2001	64441392
C-reactive protein increased	18.65	10.04	33	55306	94876	64348517
Flight of ideas	18.58	10.04	10	55329	701	64442692
Off label use	18.53	10.04	408	54931	632398	63810995
Implant site inflammation	18.33	10.04	7	55332	218	64443175
Pancreatic calcification	18.24	10.04	7	55332	221	64443172
Urticaria	18.20	10.04	65	55274	147252	64296141
Glucocorticoids increased	17.93	10.04	6	55333	126	64443267
Pancreatic duct stenosis	17.92	10.04	7	55332	232	64443161
Product dose omission issue	17.88	10.04	250	55089	194497	64248896
Hypoglycaemia	17.73	10.04	135	55204	89757	64353636
Cytomegalovirus infection	17.65	10.04	5	55334	37194	64406199
Iron deficiency	17.61	10.04	26	55313	7151	64436242
Exposure via breast milk	17.55	10.04	10	55329	784	64442609
Hypovolaemia	17.38	10.04	40	55299	15446	64427947
Hypoosmolar state	17.24	10.04	7	55332	257	64443136
Hypokalaemia	17.21	10.04	170	55169	121733	64321660
Drug eruption	16.89	10.04	5	55334	36131	64407262
Cortical visual impairment	16.78	10.04	4	55335	22	64443371
Drug dependence	16.72	10.04	4	55335	33308	64410085
Upper gastrointestinal haemorrhage	16.58	10.04	67	55272	35153	64408240
Pulmonary oedema	16.57	10.04	120	55219	78554	64364839
Diarrhoea	16.16	10.04	766	54573	721938	63721455
Infective pulmonary exacerbation of cystic fibrosis	16.13	10.04	33	55306	11763	64431630
Respiratory failure	16.06	10.04	210	55129	160973	64282420
Gastrointestinal angiodysplasia	16.05	10.04	10	55329	923	64442470
Mucosal inflammation	16.03	10.04	18	55321	62566	64380827
Lactation disorder	15.77	10.04	6	55333	185	64443208
Haematochezia	15.60	10.04	104	55235	66269	64377124
Hyperlactacidaemia	15.58	10.04	20	55319	4824	64438569
Pain	15.58	10.04	359	54980	553152	63890241
Hypersensitivity	15.36	10.04	102	55237	196350	64247043
Cardiac dysfunction	15.35	10.04	16	55323	3090	64440303
International normalised ratio increased	15.12	10.04	118	55221	79049	64364344
Autoimmune haemolytic anaemia	15.06	10.04	24	55315	7052	64436341
Cellulitis	14.91	10.04	134	55205	93523	64349870
Thermohypoaesthesia	14.86	10.04	5	55334	107	64443286
Respiratory tract malformation	14.69	10.04	4	55335	40	64443353
Pancreatic mass	14.68	10.04	11	55328	1373	64442020
Wound	14.65	10.04	27	55312	76450	64366943
Blood creatine phosphokinase MM increased	14.60	10.04	4	55335	41	64443352
Abdominal distension	14.60	10.04	136	55203	95858	64347535
Hypermagnesaemia	14.57	10.04	10	55329	1087	64442306
Therapeutic response decreased	14.51	10.04	14	55325	52174	64391219
Sight disability	14.44	10.04	5	55334	117	64443276
Accidental overdose	14.36	10.04	62	55277	33495	64409898
Folliculitis	14.35	10.04	4	55335	30073	64413320
Renal arteriosclerosis	14.23	10.04	6	55333	243	64443150
Syncope	13.92	10.04	201	55138	157434	64285959
Abdominal pain	13.73	10.04	358	54981	312017	64131376
Maternal condition affecting foetus	13.63	10.04	5	55334	139	64443254
Lower gastrointestinal haemorrhage	13.49	10.04	34	55305	13905	64429488
Epistaxis	13.43	10.04	136	55203	97995	64345398
Foreign body aspiration	13.39	10.04	6	55333	282	64443111
Mobility decreased	13.38	10.04	34	55305	85806	64357587
Haemorrhagic erosive gastritis	13.27	10.04	7	55332	471	64442922
Lethargy	13.20	10.04	107	55232	72487	64370906
Poor sucking reflex	13.15	10.04	4	55335	61	64443332
Infected neoplasm	13.09	10.04	6	55333	297	64443096
Bronchopulmonary disease	12.99	10.04	3	55336	14	64443379
Sinus node dysfunction	12.97	10.04	22	55317	6806	64436587
Nasopharyngitis	12.85	10.04	107	55232	195966	64247427
Asocial behaviour	12.74	10.04	4	55335	68	64443325
Therapy interrupted	12.72	10.04	42	55297	19994	64423399
Coma	12.68	10.04	36	55303	87579	64355814
Pancreatic injury	12.65	10.04	5	55334	171	64443222
Injection site reaction	12.42	10.04	13	55326	46651	64396742
Meningism	12.32	10.04	7	55332	546	64442847
General physical health deterioration	12.31	10.04	114	55225	204311	64239082
Suicidal ideation	12.30	10.04	24	55315	66518	64376875
Acidosis	11.92	10.04	38	55301	17757	64425636
Exposure during pregnancy	11.78	10.04	110	55229	77565	64365828
Radiation proctitis	11.78	10.04	4	55335	88	64443305
Inability to afford medication	11.70	10.04	11	55328	1875	64441518
Inflammation	11.69	10.04	24	55315	65276	64378117
Rash	11.63	10.04	302	55037	458247	63985146
Sepsis	11.61	10.04	269	55070	230072	64213321
Psoriatic arthropathy	11.59	10.04	12	55327	43269	64400124
Hip fracture	11.54	10.04	50	55289	27049	64416344
Hepatic encephalopathy	11.49	10.04	42	55297	21024	64422369
Ludwig angina	11.49	10.04	5	55334	219	64443174
Clostridium difficile colitis	11.42	10.04	50	55289	27173	64416220
Depressed level of consciousness	11.39	10.04	34	55305	81402	64361991
Arteriovenous malformation	11.36	10.04	10	55329	1566	64441827
Premature labour	11.24	10.04	22	55317	7598	64435795
Small intestinal obstruction	11.22	10.04	45	55294	23528	64419865
Internal haemorrhage	11.14	10.04	22	55317	7645	64435748
Blood iron decreased	11.11	10.04	29	55310	12113	64431280
Haemoglobin abnormal	10.95	10.04	19	55320	5985	64437408
Pneumocystis jirovecii pneumonia	10.93	10.04	5	55334	27629	64415764
Cellulitis orbital	10.91	10.04	7	55332	680	64442713
Abdominal discomfort	10.84	10.04	102	55237	182220	64261173
Hepatic cirrhosis	10.80	10.04	48	55291	26250	64417143
Sinusitis	10.79	10.04	77	55262	145851	64297542
Failure to thrive	10.73	10.04	26	55313	10378	64433015
Renal tubular acidosis	10.70	10.04	13	55326	2966	64440427
Regurgitation	10.66	10.04	11	55328	2098	64441295
Rectal haemorrhage	10.64	10.04	90	55249	61727	64381666
Musculoskeletal pain	10.63	10.04	35	55304	81259	64362134
Crystal urine	10.61	10.04	4	55335	120	64443273
Sopor	10.61	10.04	52	55287	29609	64413784
Inflammatory bowel disease	10.51	10.04	16	55323	4522	64438871
Uterine haemorrhage	10.50	10.04	12	55327	2567	64440826
Antipsychotic drug level increased	10.41	10.04	17	55322	5098	64438295
Suicide attempt	10.41	10.04	29	55310	70978	64372415
Haemorrhage	10.40	10.04	109	55230	79242	64364151
Oxygen consumption increased	10.39	10.04	16	55323	4565	64438828
Unwanted awareness during anaesthesia	10.33	10.04	5	55334	280	64443113
Infection	10.33	10.04	105	55234	184775	64258618
Enterocolitis bacterial	10.33	10.04	6	55333	488	64442905
Dehydration	10.27	10.04	251	55088	216512	64226881
Hyponatraemic seizure	10.25	10.04	6	55333	495	64442898
Colon cancer	10.23	10.04	29	55310	12710	64430683
Chest pain	10.23	10.04	270	55069	235710	64207683
Colitis ulcerative	10.20	10.04	43	55296	22985	64420408
Stillbirth	10.15	10.04	14	55325	3619	64439774

FDA Adverse Event Reporting System (Pediatric)

None

Pharmacologic Action:

Source	Code	Description
ATC	B03AA07	BLOOD AND BLOOD FORMING ORGANS ANTIANEMIC PREPARATIONS IRON PREPARATIONS Iron bivalent, oral preparations
ATC	B03AD03	BLOOD AND BLOOD FORMING ORGANS ANTIANEMIC PREPARATIONS IRON PREPARATIONS Iron in combination with folic acid
CHEBI has role	CHEBI:63247	reducer

Drug Use | Suggest Off label Use Form| |View source of the data|

Disease	Relation	SNOMED_ID	DOID
Anemia of prematurity	indication	47100003	DOID:11243
Megaloblastic anemia due to folate deficiency	indication	85649008	DOID:14026
Vitamin deficiency	indication	85670002
Iron deficiency anemia	indication	87522002
Mineral deficiency	indication	111379007
Mineral Deficiency Prevention	indication
Vitamin Deficiency Prevention	indication
Peptic ulcer	contraindication	13200003	DOID:750
Operation on stomach	contraindication	16453004
Primary hyperoxaluria	contraindication	17901006	DOID:2977
Gastroenteritis	contraindication	25374005	DOID:2326
Hemosiderosis	contraindication	39011001	DOID:12119
Hemolytic anemia	contraindication	61261009	DOID:583
Ulcerative colitis	contraindication	64766004	DOID:8577
Anemia due to enzyme deficiency	contraindication	111577008
Hb SS disease	contraindication	127040003	DOID:10923
Esophageal dysmotility	contraindication	266434009	DOID:9192
Diverticular disease	contraindication	397881000
Hemochromatosis	contraindication	399187006	DOID:2352
Repeated Blood Transfusions	contraindication

🐶 Veterinary Drug Use

None

🐶 Veterinary products

None

Acid dissociation constants calculated using MoKa v3.0.0

None

Orange Book patent data (new drug applications)

None

Orange Book exclusivity data (new drug applications)

None

Bioactivity Summary:

None

External reference:

ID	Source
D04172	KEGG_DRUG
4017707	VUID
N0000146077	NUI
4017662	VANDF
4017664	VANDF
4017707	VANDF
CHEBI:75832	CHEBI
CHEMBL1200830	ChEMBL_ID
C020748	MESH_SUPPLEMENTAL_RECORD_UI
39R4TAN1VT	UNII
24393	PUBCHEM_CID
24947	RXNORM
4725	MMSL
4920	MMSL
6168	MMSL
63844	MMSL
d03824	MMSL
000840	NDDF
007813	NDDF
387402000	SNOMEDCT_US
71724000	SNOMEDCT_US
C0060282	UMLSCUI
7782-63-0	SECONDARY_CAS_RN

Pharmaceutical products:

Product	Category	Ingredients	NDC	Form	Quantity	Route	Marketing	Label
Quflora FE Pediatric Drops	HUMAN PRESCRIPTION DRUG LABEL	14	15370-102	LIQUID	9.50 mg	ORAL	UNAPPROVED DRUG OTHER	11 sections
FERROUS SULFATE	HUMAN OTC DRUG LABEL	1	50436-5890	TABLET	325 mg	ORAL	Unapproved drug other	10 sections
FERROUS SULFATE	HUMAN OTC DRUG LABEL	1	53807-177	ELIXIR	220 mg	ORAL	UNAPPROVED DRUG OTHER	15 sections
FERROUS SULFATE	HUMAN OTC DRUG LABEL	1	53808-0918	TABLET	325 mg	ORAL	UNAPPROVED DRUG OTHER	10 sections
Ferrous Sulfate	HUMAN OTC DRUG LABEL	1	54738-963	TABLET	325 mg	ORAL	unapproved drug other	11 sections
Ferrous Sulfate	HUMAN OTC DRUG LABEL	1	54738-963	TABLET	325 mg	ORAL	unapproved drug other	11 sections
FERROUS SULFATE	HUMAN OTC DRUG LABEL	2	58607-113	TABLET	65 mg	ORAL	unapproved drug other	9 sections
Multi-Vitamin Drops with Fluoride and Iron	HUMAN PRESCRIPTION DRUG LABEL	10	58657-327	LIQUID	10 mg	ORAL	unapproved drug other	10 sections
Ferrous Sulfate	HUMAN OTC DRUG LABEL	1	67296-1555	TABLET, FILM COATED	325 mg	ORAL	unapproved drug other	10 sections
Ferrous Sulfate	HUMAN PRESCRIPTION DRUG LABEL	1	69517-133	TABLET	65 mg	ORAL	unapproved drug other	6 sections
Ferrous Sulfate	Human OTC Drug Label	1	76413-308	TABLET, FILM COATED	325 mg	ORAL	UNAPPROVED DRUG OTHER	10 sections
Ferrous Sulfate	Human OTC Drug Label	1	76413-356	TABLET, FILM COATED	325 mg	ORAL	UNAPPROVED DRUG OTHER	11 sections