teriparatide Indications/Contra | FAERs-F | FAERs-M | Orange Bk | BioActivity |

Stem definitionDrug idCAS RN
peptides and glycopeptides 4514 52232-67-4

Description:

MoleculeDescription

Molfile Inchi Smiles

Synonyms:

  • teriparatide recombinant human
  • forsteo
  • teriparatide
  • teriparatide acetate
  • hPTH 1-34
  • parathar
A polypeptide that consists of the 1-34 amino-acid fragment of human PARATHYROID HORMONE, the biologically active N-terminal region. The acetate form is given by intravenous infusion in the differential diagnosis of HYPOPARATHYROIDISM and PSEUDOHYPOPARATHYROIDISM. (Reynolds JEF(Ed): Martindale: The Extra Pharmacopoeia (electronic version). Micromedex, Inc, Englewood, CO, 1995)
  • Molecular weight: 4117.77
  • Formula: C181H291N55O51S2
  • CLOGP:
  • LIPINSKI: None
  • HAC: 106
  • HDO: 60
  • TPSA: 1752.65
  • ALOGS:
  • ROTB: 144

Drug dosage:

DoseUnitRoute
20 mcg P

ADMET properties:

PropertyValueReference
Vd (Volume of distribution) 0.17 L/kg Lombardo F, Berellini G, Obach RS
CL (Clearance) 21.40 mL/min/kg Lombardo F, Berellini G, Obach RS
t_half (Half-life) 0.14 hours Lombardo F, Berellini G, Obach RS

Approvals:

DateAgencyCompanyOrphan
July 23, 2019 PMDA Eli Lilly Japan
June 10, 2003 EMA
Nov. 26, 2002 FDA LILLY

FDA Adverse Event Reporting System (Female)

MedDRA adverse event termLikelihood ratioLikelihood ratio thresholdPatients taking drug having adverse eventPatients taking drug not having adverse eventPatients not taking drug having adverse eventPatients not taking drug not having adverse event
Fall 1318.49 13.14 1900 64361 356540 52926265
Product complaint 1193.31 13.14 480 65781 11777 53271028
Blood calcium increased 936.63 13.14 361 65900 7875 53274930
Hip fracture 747.24 13.14 455 65806 27802 53255003
Bone pain 697.86 13.14 546 65715 50176 53232629
Muscle spasms 516.26 13.14 731 65530 134064 53148741
Injection site haemorrhage 477.50 13.14 313 65948 21738 53261067
Therapy cessation 472.69 13.14 341 65920 27684 53255121
Hospitalisation 456.99 13.14 500 65761 70512 53212293
Drug ineffective 436.45 13.14 238 66023 817007 52465798
Spinal fracture 434.47 13.14 265 65996 16220 53266585
Product storage error 416.67 13.14 238 66023 12892 53269913
Dizziness 405.22 13.14 1194 65067 371065 52911740
Femur fracture 351.87 13.14 332 65929 39253 53243552
Pelvic fracture 326.40 13.14 199 66062 12165 53270640
Hypercalcaemia 321.44 13.14 256 66005 24092 53258713
Pain in extremity 284.78 13.14 888 65373 284162 52998643
Injection site erythema 276.36 13.14 406 65855 76843 53205962
Fracture 271.67 13.14 205 66056 17814 53264991
Wrist fracture 270.23 13.14 176 66085 12079 53270726
Injection site bruising 241.83 13.14 265 65996 37381 53245424
Back pain 240.47 13.14 737 65524 233510 53049295
Bone density decreased 234.46 13.14 155 66106 10909 53271896
Toxicity to various agents 214.74 13.14 15 66246 219583 53063222
Rib fracture 209.28 13.14 185 66076 20093 53262712
Arthralgia 201.18 13.14 1075 65186 438708 52844097
Injection site haematoma 186.26 13.14 109 66152 6176 53276629
Off label use 177.94 13.14 195 66066 472017 52810788
Upper limb fracture 171.98 13.14 153 66108 16754 53266051
Drug intolerance 170.24 13.14 26 66235 205467 53077338
Injection site pain 168.43 13.14 409 65852 112982 53169823
Rheumatoid arthritis 164.85 13.14 93 66168 314438 52968367
Spinal operation 163.03 13.14 101 66160 6350 53276455
Feeling abnormal 155.03 13.14 443 65818 134858 53147947
Completed suicide 152.83 13.14 4 66257 138197 53144608
Acute kidney injury 151.34 13.14 63 66198 253805 53029000
Neutropenia 146.90 13.14 14 66247 159171 53123634
Infusion related reaction 143.17 13.14 14 66247 155943 53126862
Drug hypersensitivity 138.11 13.14 79 66182 265163 53017642
Lumbar vertebral fracture 133.70 13.14 81 66180 4891 53277914
Asthenia 133.09 13.14 804 65457 342786 52940019
Treatment failure 130.77 13.14 7 66254 128396 53154409
Nephrolithiasis 128.21 13.14 191 66070 36556 53246249
Femoral neck fracture 127.72 13.14 96 66165 8287 53274518
Product dose omission issue 125.80 13.14 521 65740 191099 53091706
Vertebroplasty 119.84 13.14 35 66226 307 53282498
Drug interaction 118.98 13.14 62 66199 219267 53063538
Febrile neutropenia 112.52 13.14 4 66257 104932 53177873
Spinal compression fracture 106.88 13.14 107 66154 13583 53269222
Chronic obstructive pulmonary disease 106.78 13.14 235 66026 60838 53221967
Bone disorder 106.56 13.14 130 66131 20553 53262252
Compression fracture 105.23 13.14 77 66184 6379 53276426
Pyrexia 104.61 13.14 215 66046 402978 52879827
Foot fracture 101.59 13.14 128 66133 20911 53261894
Therapeutic product effect decreased 101.52 13.14 17 66244 125638 53157167
Synovitis 95.62 13.14 11 66250 107882 53174923
Humerus fracture 92.40 13.14 79 66182 8200 53274605
Surgery 91.86 13.14 152 66109 31812 53250993
Thoracic vertebral fracture 89.24 13.14 60 66201 4341 53278464
Heart rate increased 87.93 13.14 263 65998 82052 53200753
Therapeutic product effect incomplete 87.55 13.14 7 66254 91777 53191028
Gait disturbance 86.81 13.14 409 65852 158433 53124372
Blood alkaline phosphatase increased 86.12 13.14 171 66090 41191 53241614
Thrombocytopenia 84.91 13.14 33 66228 138694 53144111
Glossodynia 82.28 13.14 13 66248 100278 53182527
Product use issue 80.92 13.14 36 66225 139548 53143257
Product use in unapproved indication 80.73 13.14 20 66241 112269 53170536
Disease progression 79.69 13.14 15 66246 101905 53180900
Hand deformity 79.48 13.14 7 66254 84842 53197963
Ankle fracture 77.40 13.14 99 66162 16416 53266389
Palpitations 77.33 13.14 291 65970 102057 53180748
Myalgia 76.07 13.14 348 65913 133143 53149662
Osteitis deformans 74.92 13.14 23 66238 243 53282562
Therapy interrupted 72.08 13.14 104 66157 19332 53263473
Medication error 71.72 13.14 147 66114 36218 53246587
Patella fracture 68.83 13.14 38 66223 1924 53280881
Systemic lupus erythematosus 68.62 13.14 35 66226 125379 53157426
Contusion 67.08 13.14 294 65967 110438 53172367
Malignant neoplasm progression 66.74 13.14 6 66255 71535 53211270
Tibia fracture 66.54 13.14 52 66209 4755 53278050
Cerebrovascular accident 65.81 13.14 282 65979 104892 53177913
Hand fracture 64.97 13.14 51 66210 4694 53278111
Lower limb fracture 64.76 13.14 84 66177 14121 53268684
Vitamin D decreased 64.08 13.14 66 66195 8663 53274142
Hepatic enzyme increased 63.59 13.14 39 66222 126156 53156649
White blood cell count decreased 63.38 13.14 38 66223 124437 53158368
Drug abuse 62.48 13.14 5 66256 65521 53217284
Diarrhoea 62.17 13.14 489 65772 625057 52657748
Intentional overdose 61.72 13.14 6 66255 67199 53215606
Recalled product 60.24 13.14 31 66230 1360 53281445
Psoriasis 59.77 13.14 17 66244 87072 53195733
Leukopenia 59.18 13.14 10 66251 73453 53209352
Stomatitis 58.98 13.14 24 66237 98134 53184671
Rash 58.86 13.14 320 65941 445871 52836934
Stress fracture 58.14 13.14 58 66203 7329 53275476
Pancytopenia 53.40 13.14 23 66238 90905 53191900
Condition aggravated 52.49 13.14 191 66070 296943 52985862
Platelet count decreased 52.28 13.14 35 66226 108064 53174741
Cardiac disorder 51.97 13.14 152 66109 46814 53235991
Lower respiratory tract infection 51.88 13.14 24 66237 90957 53191848
Hip arthroplasty 51.86 13.14 110 66151 27752 53255053
Wound 49.41 13.14 26 66235 91531 53191274
Fractured sacrum 47.74 13.14 30 66231 1933 53280872
Hip surgery 47.63 13.14 34 66227 2709 53280096
Pericarditis 47.21 13.14 11 66250 64395 53218410
Anaphylactic reaction 46.85 13.14 8 66253 58318 53224487
Balance disorder 46.32 13.14 197 66064 73010 53209795
Blood parathyroid hormone increased 46.02 13.14 35 66226 3074 53279731
Nausea 45.87 13.14 1245 65016 754846 52527959
Suicide attempt 44.53 13.14 9 66252 58159 53224646
Head injury 43.54 13.14 98 66163 25735 53257070
Neutrophil count decreased 43.50 13.14 5 66256 49093 53233712
Malaise 42.76 13.14 652 65609 356965 52925840
Myocardial infarction 42.49 13.14 239 66022 99115 53183690
Breast cancer 42.05 13.14 146 66115 49212 53233593
Urine calcium increased 42.03 13.14 11 66250 61 53282744
Therapeutic response decreased 41.76 13.14 5 66256 47564 53235241
Calciphylaxis 41.75 13.14 32 66229 2843 53279962
Musculoskeletal discomfort 41.71 13.14 72 66189 15588 53267217
Swelling 41.36 13.14 112 66149 190993 53091812
Pain 41.23 13.14 988 65273 587410 52695395
Nervousness 40.68 13.14 105 66156 30073 53252732
Dyspnoea 40.59 13.14 500 65761 585732 52697073
Hypotension 40.57 13.14 170 66091 253906 53028899
Abdominal pain 40.38 13.14 172 66089 255731 53027074
Pathological fracture 40.26 13.14 51 66210 8373 53274432
Bradycardia 40.11 13.14 19 66242 71037 53211768
Cervical vertebral fracture 40.00 13.14 29 66232 2368 53280437
Intentional product use issue 39.99 13.14 20 66241 72474 53210331
Body height decreased 39.79 13.14 55 66206 9824 53272981
Arrhythmia 39.70 13.14 118 66143 36661 53246144
Bone fissure 39.63 13.14 13 66248 173 53282632
Fracture nonunion 39.62 13.14 29 66232 2403 53280402
Injection site rash 38.74 13.14 72 66189 16507 53266298
Neuropathy peripheral 38.26 13.14 43 66218 103144 53179661
Peripheral swelling 38.02 13.14 130 66131 205978 53076827
Lung neoplasm malignant 37.60 13.14 72 66189 16880 53265925
Device failure 37.32 13.14 42 66219 6093 53276712
Fear 37.31 13.14 71 66190 16570 53266235
Hypokalaemia 37.13 13.14 39 66222 96478 53186327
Ulna fracture 37.12 13.14 21 66240 1115 53281690
Alanine aminotransferase increased 37.07 13.14 38 66223 95057 53187748
Breast cancer in situ 36.88 13.14 23 66238 1462 53281343
Incorrect product administration duration 36.72 13.14 55 66206 10569 53272236
Osteoporosis 36.64 13.14 134 66127 46326 53236479
Road traffic accident 36.44 13.14 91 66170 25540 53257265
Radius fracture 36.24 13.14 32 66229 3467 53279338
Wheezing 36.01 13.14 18 66243 65257 53217548
Death 35.90 13.14 633 65628 356599 52926206
Accident 35.66 13.14 39 66222 5482 53277323
Fibula fracture 35.19 13.14 30 66231 3101 53279704
Sinusitis 34.83 13.14 101 66160 168463 53114342
Helicobacter infection 34.56 13.14 4 66257 39065 53243740
Hypersensitivity 34.21 13.14 140 66121 210525 53072280
N-telopeptide urine increased 34.15 13.14 6 66255 0 53282805
Osteocalcin increased 34.15 13.14 6 66255 0 53282805
Calcinosis 33.74 13.14 24 66237 1902 53280903
Transient ischaemic attack 33.37 13.14 109 66152 35616 53247189
Multiple fractures 33.30 13.14 41 66220 6540 53276265
Movement disorder 32.75 13.14 72 66189 18609 53264196
Duodenal ulcer perforation 32.68 13.14 3 66258 35180 53247625
Injury associated with device 32.50 13.14 29 66232 3186 53279619
Blood calcium abnormal 32.46 13.14 19 66242 1076 53281729
Haemoglobin decreased 32.38 13.14 77 66184 137230 53145575
Suicidal ideation 31.46 13.14 18 66243 60493 53222312
Weight decreased 31.44 13.14 437 65824 234511 53048294
Post procedural complication 31.25 13.14 66 66195 16600 53266205
Joint swelling 31.00 13.14 168 66093 234470 53048335
Agitation 29.68 13.14 18 66243 58608 53224197
Joint dislocation 29.33 13.14 54 66207 12291 53270514
Muscular weakness 29.11 13.14 220 66041 100772 53182033
Accidental underdose 28.96 13.14 15 66246 667 53282138
Back disorder 28.91 13.14 47 66214 9688 53273117
Neck pain 28.78 13.14 149 66112 59867 53222938
Hernial eventration 28.67 13.14 6 66255 9 53282796
Multiple sclerosis relapse 28.55 13.14 10 66251 44843 53237962
Atypical femur fracture 28.41 13.14 34 66227 5267 53277538
Vomiting 27.93 13.14 442 65819 496697 52786108
Metabolic acidosis 27.61 13.14 9 66252 42233 53240572
Loss of consciousness 27.60 13.14 239 66022 113973 53168832
Sternal fracture 27.47 13.14 21 66240 1858 53280947
Hyperparathyroidism 27.27 13.14 24 66237 2589 53280216
Clavicle fracture 27.24 13.14 26 66235 3112 53279693
Memory impairment 26.93 13.14 189 66072 84568 53198237
Bone marrow failure 26.84 13.14 3 66258 30112 53252693
Emphysema 26.80 13.14 46 66215 9913 53272892
Neoplasm progression 26.62 13.14 3 66258 29916 53252889
Folliculitis 26.25 13.14 4 66257 31705 53251100
Hypercalciuria 26.06 13.14 10 66251 215 53282590
Breast calcifications 25.85 13.14 17 66244 1185 53281620
Angioedema 25.74 13.14 10 66251 42066 53240739
Oxygen saturation decreased 25.27 13.14 35 66226 76690 53206115
Blood bilirubin increased 24.46 13.14 7 66254 35723 53247082
Bone scan abnormal 24.42 13.14 11 66250 358 53282447
Rhabdomyolysis 24.40 13.14 12 66249 43911 53238894
C-reactive protein increased 24.39 13.14 29 66232 67857 53214948
Hyperkalaemia 24.35 13.14 19 66242 54237 53228568
Facial bones fracture 24.34 13.14 26 66235 3558 53279247
Headache 23.90 13.14 852 65409 535969 52746836
Encephalopathy 23.78 13.14 8 66253 36800 53246005
Heart rate irregular 23.54 13.14 67 66194 20317 53262488
Dementia Alzheimer's type 23.51 13.14 16 66245 1181 53281624
Cardio-respiratory arrest 23.44 13.14 23 66238 58735 53224070
Pulmonary arterial hypertension 23.44 13.14 3 66258 27119 53255686
Enchondromatosis 23.33 13.14 7 66254 68 53282737
Aspartate aminotransferase increased 23.27 13.14 43 66218 83986 53198819
Nerve compression 23.22 13.14 37 66224 7499 53275306
Vein disorder 23.21 13.14 28 66233 4373 53278432
Breast cancer female 23.19 13.14 35 66226 6769 53276036
Spinal deformity 23.18 13.14 15 66246 1017 53281788
Prosthesis implantation 23.15 13.14 7 66254 70 53282735
Blister 22.98 13.14 39 66222 78714 53204091
Liver function test increased 22.88 13.14 3 66258 26625 53256180
Hyponatraemia 22.47 13.14 65 66196 108542 53174263
Addison's disease 22.23 13.14 7 66254 81 53282724
Drug withdrawal syndrome 22.16 13.14 4 66257 28018 53254787
Colon cancer 22.12 13.14 42 66219 9783 53273022
Ilium fracture 22.06 13.14 8 66253 146 53282659
Fluid overload 21.95 13.14 4 66257 27827 53254978
Cough 21.74 13.14 209 66052 256684 53026121
Abdominal discomfort 21.74 13.14 173 66088 220889 53061916
Groin pain 21.73 13.14 41 66220 9507 53273298
Hallucination, synaesthetic 21.61 13.14 6 66255 43 53282762
Calcium ionised increased 21.47 13.14 8 66253 158 53282647
Vertigo 21.43 13.14 131 66130 55950 53226855
Hepatic cancer 21.35 13.14 24 66237 3477 53279328
Drug eruption 21.15 13.14 3 66258 25091 53257714
Fracture malunion 20.98 13.14 8 66253 169 53282636
Hernia hiatus repair 20.92 13.14 6 66255 49 53282756
Bone cancer 20.65 13.14 15 66246 1228 53281577
Productive cough 20.63 13.14 24 66237 56705 53226100
Pleural effusion 20.61 13.14 50 66211 88529 53194276
Extraskeletal ossification 20.61 13.14 6 66255 52 53282753
Cementoplasty 20.53 13.14 4 66257 3 53282802
Transaminases increased 20.45 13.14 6 66255 30126 53252679
Limb discomfort 20.45 13.14 74 66187 25448 53257357
Serotonin syndrome 20.39 13.14 4 66257 26402 53256403
Dysstasia 20.35 13.14 61 66200 19038 53263767
Neoplasm malignant 20.32 13.14 74 66187 25527 53257278
Hepatocellular injury 20.30 13.14 6 66255 29980 53252825
Hypoacusis 20.25 13.14 68 66193 22531 53260274
Leukaemia 20.24 13.14 24 66237 3682 53279123
Muscle injury 20.07 13.14 6 66255 29760 53253045
Rash maculo-papular 20.05 13.14 6 66255 29743 53253062
Oedema 19.75 13.14 39 66222 74307 53208498
Injection site irritation 19.69 13.14 26 66235 4446 53278359
Gammopathy 19.65 13.14 7 66254 121 53282684
Product distribution issue 19.53 13.14 11 66250 579 53282226
Joint injury 19.36 13.14 66 66195 22034 53260771
Osteoporotic fracture 19.23 13.14 22 66239 3249 53279556
Hepatitis 19.22 13.14 9 66252 33885 53248920
Visual acuity reduced 18.70 13.14 66 66195 22419 53260386
Intestinal obstruction 18.68 13.14 78 66183 28663 53254142
Musculoskeletal chest pain 18.26 13.14 60 66201 19662 53263143
Sleep disorder due to a general medical condition 18.20 13.14 33 66228 7424 53275381
Blood creatinine increased 18.20 13.14 48 66213 82614 53200191
General physical health deterioration 17.89 13.14 108 66153 146834 53135971
Parkinson's disease 17.88 13.14 15 66246 1516 53281289
Influenza 17.79 13.14 189 66072 95190 53187615
Spinal disorder 17.67 13.14 36 66225 8828 53273977
Face injury 17.67 13.14 20 66241 2920 53279885
International normalised ratio increased 17.59 13.14 20 66241 47741 53235064
Injection site streaking 17.53 13.14 5 66256 40 53282765
Tetany 17.40 13.14 16 66245 1827 53280978
Cataract operation 17.29 13.14 24 66237 4304 53278501
Growing pains 17.24 13.14 4 66257 12 53282793
Septic shock 17.09 13.14 32 66229 62197 53220608
Mucinous breast carcinoma 17.08 13.14 3 66258 0 53282805
Wrong product stored 17.08 13.14 3 66258 0 53282805
Type 2 diabetes mellitus 17.07 13.14 9 66252 31661 53251144
Joint arthroplasty 17.05 13.14 17 66244 2147 53280658
Rehabilitation therapy 16.96 13.14 14 66247 1384 53281421
Gait inability 16.92 13.14 93 66168 38218 53244587
Upper respiratory tract infection 16.88 13.14 38 66223 69059 53213746
Anaemia 16.88 13.14 242 66019 276476 53006329
Liver function test abnormal 16.77 13.14 21 66240 48050 53234755
Pseudarthrosis 16.70 13.14 9 66252 434 53282371
Product quality issue 16.57 13.14 13 66248 37010 53245795
Cardiac pacemaker insertion 16.42 13.14 22 66239 3815 53278990
Injection site discolouration 16.39 13.14 31 66230 7199 53275606
Hallucination 16.32 13.14 26 66235 53812 53228993
Drug ineffective for unapproved indication 16.29 13.14 3 66258 20717 53262088
Cystitis 16.24 13.14 107 66154 46881 53235924
Scoliosis 16.22 13.14 30 66231 6852 53275953
Pulmonary embolism 16.19 13.14 80 66181 114362 53168443
Constipation 15.93 13.14 340 65921 198072 53084733
Posture abnormal 15.92 13.14 17 66244 2326 53280479
Coma 15.90 13.14 33 66228 61750 53221055
Knee arthroplasty 15.85 13.14 83 66178 33486 53249319
Spinal fusion surgery 15.70 13.14 22 66239 3979 53278826
Osteonecrosis 15.64 13.14 70 66191 26505 53256300
Parathyroid tumour benign 15.57 13.14 10 66251 669 53282136
Blood calcium decreased 15.53 13.14 57 66204 19737 53263068
Knee operation 15.41 13.14 25 66236 5143 53277662
Blood lactate dehydrogenase increased 15.41 13.14 4 66257 21777 53261028
Dyspnoea exertional 15.35 13.14 28 66233 54972 53227833
Ascites 15.34 13.14 16 66245 39719 53243086
Somnolence 15.24 13.14 134 66127 167600 53115205
Sedation 15.18 13.14 9 66252 29666 53253139
Lymphocyte count decreased 15.08 13.14 8 66253 28044 53254761
Intentional product misuse 15.02 13.14 109 66152 49283 53233522
Traumatic shock 15.00 13.14 3 66258 3 53282802
Basosquamous carcinoma of skin 15.00 13.14 3 66258 3 53282802
Dystrophic calcification 14.94 13.14 6 66255 146 53282659
Depressed level of consciousness 14.93 13.14 28 66233 54400 53228405
Inguinal hernia 14.84 13.14 15 66246 1925 53280880
Complication associated with device 14.80 13.14 49 66212 16116 53266689
Stevens-Johnson syndrome 14.77 13.14 6 66255 24576 53258229
Spinal stenosis 14.71 13.14 45 66216 14196 53268609
Psychotic disorder 14.58 13.14 6 66255 24379 53258426
Gastrointestinal haemorrhage 14.57 13.14 51 66210 80279 53202526
Jaw disorder 14.54 13.14 25 66236 5393 53277412
Wrong technique in device usage process 14.54 13.14 17 66244 2570 53280235
Hyperglycaemia 14.53 13.14 17 66244 40067 53242738
Cardiac flutter 14.34 13.14 20 66241 3602 53279203
Skeletal injury 14.30 13.14 12 66249 1214 53281591
Cholestasis 14.26 13.14 9 66252 28686 53254119
Infection 14.17 13.14 141 66120 172064 53110741
Urinary bladder polyp 14.17 13.14 5 66256 84 53282721
Acetabulum fracture 14.13 13.14 7 66254 283 53282522
Hepatic function abnormal 14.08 13.14 15 66246 36884 53245921
Extrasystoles 14.08 13.14 24 66237 5142 53277663
Mass 14.00 13.14 41 66220 12628 53270177
Neoplasm 13.98 13.14 27 66234 6369 53276436
Liver injury 13.94 13.14 5 66256 22098 53260707
Manufacturing product shipping issue 13.90 13.14 5 66256 89 53282716
Uterine operation 13.79 13.14 3 66258 6 53282799
N-telopeptide urine decreased 13.79 13.14 3 66258 6 53282799
Oestrogen receptor assay positive 13.75 13.14 8 66253 448 53282357
Pain in jaw 13.69 13.14 92 66169 40577 53242228
Cardiac arrest 13.52 13.14 65 66196 93602 53189203
Limb crushing injury 13.50 13.14 6 66255 189 53282616
Vascular injury 13.48 13.14 10 66251 846 53281959
Hiatus hernia 13.34 13.14 54 66207 19566 53263239
Femoral hernia 13.23 13.14 4 66257 40 53282765
Hypoglycaemia 13.19 13.14 34 66227 58979 53223826
Abdominal strangulated hernia 13.18 13.14 5 66256 104 53282701

FDA Adverse Event Reporting System (Male)

MedDRA adverse event termLikelihood ratioLikelihood ratio thresholdPatients taking drug having adverse eventPatients taking drug not having adverse eventPatients not taking drug having adverse eventPatients not taking drug not having adverse event
Hospitalisation 127.70 20.22 91 5987 48880 32458568
Hip fracture 120.78 20.22 54 6024 11821 32495627
Product complaint 112.79 20.22 42 6036 5761 32501687
Bone pain 88.00 20.22 52 6026 20292 32487156
Spinal fracture 87.48 20.22 37 6041 7079 32500369
Fall 86.45 20.22 141 5937 196060 32311388
Therapy cessation 66.81 20.22 40 6038 15973 32491475
Spinal operation 62.69 20.22 22 6056 2543 32504905
Bone density decreased 52.65 20.22 18 6060 1924 32505524
Back pain 46.28 20.22 78 6000 110975 32396473
Muscle spasms 45.89 20.22 61 6017 70357 32437091
Death 43.51 20.22 163 5915 382354 32125094
Arthralgia 42.78 20.22 89 5989 148359 32359089
Femur fracture 41.92 20.22 23 6055 7785 32499663
Thoracic vertebral fracture 41.05 20.22 14 6064 1485 32505963
Vertebroplasty 40.56 20.22 7 6071 35 32507413
Pain in extremity 38.67 20.22 75 6003 118826 32388622
Injection site pain 37.28 20.22 38 6040 33020 32474428
Blood calcium increased 35.71 20.22 16 6062 3509 32503939
Acute kidney injury 33.64 20.22 7 6071 293461 32213987
Injection site erythema 33.04 20.22 25 6053 14643 32492805
Injection site haemorrhage 32.21 20.22 20 6058 8508 32498940
Osteoporotic fracture 32.16 20.22 11 6067 1177 32506271
Chronic obstructive pulmonary disease 31.37 20.22 42 6036 48711 32458737
Atypical femur fracture 30.45 20.22 8 6070 345 32507103
Dizziness 30.38 20.22 97 5981 209521 32297927
Fracture 28.66 20.22 17 6061 6662 32500786
Pneumonia 28.30 20.22 136 5942 355116 32152332
Pain 26.44 20.22 86 5992 187470 32319978
Injection site bruising 26.19 20.22 17 6061 7803 32499645
Product storage error 25.02 20.22 16 6062 7162 32500286
Incorrect product administration duration 23.78 20.22 13 6065 4365 32503083
Upper limb fracture 23.45 20.22 13 6065 4485 32502963
Hypercalcaemia 23.45 20.22 20 6058 13874 32493574
Tibia fracture 22.60 20.22 9 6069 1475 32505973
Injection site haematoma 22.23 20.22 9 6069 1539 32505909
Nephrolithiasis 21.43 20.22 26 6052 27328 32480120
Hernia repair 20.82 20.22 8 6070 1192 32506256
Recalled product 20.45 20.22 6 6072 390 32507058
Accidental underdose 20.33 20.22 6 6072 398 32507050

Pharmacologic Action:

SourceCodeDescription
ATC H05AA02 SYSTEMIC HORMONAL PREPARATIONS, EXCL. SEX HORMONES AND INSULINS
CALCIUM HOMEOSTASIS
PARATHYROID HORMONES AND ANALOGUES
Parathyroid hormones and analogues
FDA CS M0015931 Parathyroid Hormone
FDA EPC N0000180852 Parathyroid Hormone Analog
MeSH PA D050071 Bone Density Conservation Agents
MeSH PA D000077264 Calcium-Regulating Hormones and Agents

Drug Use (View source of the data)

DiseaseRelationSNOMED_IDDOID
Postmenopausal osteoporosis indication 102447009
Glucocorticoid Induced Osteoporosis indication
Hypogonadal Osteoporosis in Males indication
Osteitis deformans contraindication 2089002 DOID:5408
Osteomalacia contraindication 4598005 DOID:10573
Renal osteodystrophy contraindication 16726004 DOID:13068
Hepatic osteodystrophy contraindication 28193003
Rickets contraindication 41345002 DOID:10609
Low blood pressure contraindication 45007003
Hypercalcemia contraindication 66931009 DOID:12678
Osteitis fibrosa cystica generalisata contraindication 84727000 DOID:3341
Urolithiasis contraindication 95566004
Osteosarcoma of bone contraindication 307576001 DOID:3376
Breastfeeding (mother) contraindication 413712001
Bone Metastases contraindication
Malignant Bone Disease contraindication
Radiation Therapy Involving Bone contraindication

Acid dissociation constants calculated using MoKa v3.0.0

Dissociation levelDissociation constantType (acidic/basic)
pKa1 3.23 acidic
pKa2 3.31 acidic
pKa3 3.82 acidic
pKa4 4.11 acidic
pKa5 4.44 acidic
pKa6 11.68 acidic
pKa7 12.17 acidic
pKa8 12.35 acidic
pKa9 12.6 acidic
pKa10 12.63 acidic
pKa11 12.75 acidic
pKa12 12.78 acidic
pKa13 12.93 acidic
pKa14 13.16 acidic
pKa15 13.18 acidic
pKa16 13.37 acidic
pKa17 13.37 acidic
pKa18 13.44 acidic
pKa19 13.47 acidic
pKa20 13.57 acidic
pKa21 13.72 acidic
pKa22 13.72 acidic
pKa23 13.74 acidic
pKa24 13.82 acidic
pKa25 13.89 acidic
pKa26 11.47 Basic
pKa27 11.08 Basic
pKa28 10.81 Basic
pKa29 10.48 Basic
pKa30 10.09 Basic
pKa31 7.63 Basic
pKa32 7.16 Basic
pKa33 6.69 Basic
pKa34 6.21 Basic

Orange Book patent data (new drug applications)

None

Orange Book exclusivity data (new drug applications)

None

Bioactivity Summary:

TargetClassPharosUniProtActionTypeActivity value
(-log[M])
Mechanism
action
Bioact sourceMoA source
Parathyroid hormone/parathyroid hormone-related peptide receptor GPCR AGONIST IC50 7.40 IUPHAR CHEMBL
Parathyroid hormone 2 receptor GPCR AGONIST IC50 7.80 IUPHAR
Parathyroid hormone 2 receptor GPCR AGONIST IC50 6.30 IUPHAR
Parathyroid hormone/parathyroid hormone-related peptide receptor GPCR AGONIST IC50 8.70 IUPHAR

External reference:

IDSource
D03358 KEGG_DRUG
4019512 VUID
N0000147632 NUI
99294-94-7 SECONDARY_CAS_RN
4019512 VANDF
CHEBI:135983 CHEBI
CHEMBL525610 ChEMBL_ID
CHEMBL1201549 ChEMBL_ID
4448 IUPHAR_LIGAND_ID
5411 INN_ID
DB06285 DRUGBANK_ID
10T9CSU89I UNII
155817470 PUBCHEM_CID
114260 RXNORM
17041 MMSL
336918 MMSL
d04828 MMSL
002142 NDDF
004944 NDDF
109198008 SNOMEDCT_US
398823001 SNOMEDCT_US
425438001 SNOMEDCT_US
D019379 MESH_DESCRIPTOR_UI
C0070093 UMLSCUI

Pharmaceutical products:

ProductCategoryIngredientsNDCFormQuantityRouteMarketingLabel
Forteo HUMAN PRESCRIPTION DRUG LABEL 1 0002-8400 INJECTION, SOLUTION 250 ug SUBCUTANEOUS NDA 35 sections
teriparatide HUMAN PRESCRIPTION DRUG LABEL 1 47781-652 INJECTION, SOLUTION 250 ug SUBCUTANEOUS NDA 30 sections