Stem definition | Drug id | CAS RN |
---|---|---|
peptides and glycopeptides | 4514 | 52232-67-4 |
Dose | Unit | Route |
---|---|---|
20 | mcg | P |
Property | Value | Reference |
---|---|---|
Vd (Volume of distribution) | 0.17 L/kg | Lombardo F, Berellini G, Obach RS |
CL (Clearance) | 21.40 mL/min/kg | Lombardo F, Berellini G, Obach RS |
t_half (Half-life) | 0.14 hours | Lombardo F, Berellini G, Obach RS |
Date | Agency | Company | Orphan |
---|---|---|---|
July 23, 2019 | PMDA | Eli Lilly Japan | |
June 10, 2003 | EMA | ||
Nov. 26, 2002 | FDA | LILLY |
MedDRA adverse event term | Likelihood ratio | Likelihood ratio threshold | Patients taking drug having adverse event | Patients taking drug not having adverse event | Patients not taking drug having adverse event | Patients not taking drug not having adverse event |
---|---|---|---|---|---|---|
Fall | 1261.69 | 13.20 | 1834 | 63585 | 333098 | 50206607 |
Product complaint | 1205.75 | 13.20 | 480 | 64939 | 10986 | 50528719 |
Blood calcium increased | 945.35 | 13.20 | 361 | 65058 | 7358 | 50532347 |
Hip fracture | 740.53 | 13.20 | 445 | 64974 | 25486 | 50514219 |
Bone pain | 710.87 | 13.20 | 545 | 64874 | 46684 | 50493021 |
Muscle spasms | 529.36 | 13.20 | 728 | 64691 | 124825 | 50414880 |
Therapy cessation | 483.31 | 13.20 | 341 | 65078 | 25670 | 50514035 |
Drug ineffective | 475.60 | 13.20 | 235 | 65184 | 819098 | 49720607 |
Injection site haemorrhage | 468.08 | 13.20 | 310 | 65109 | 21036 | 50518669 |
Hospitalisation | 443.13 | 13.20 | 491 | 64928 | 67446 | 50472259 |
Spinal fracture | 441.19 | 13.20 | 266 | 65153 | 15307 | 50524398 |
Product storage error | 423.66 | 13.20 | 238 | 65181 | 11986 | 50527719 |
Dizziness | 423.20 | 13.20 | 1188 | 64231 | 345181 | 50194524 |
Femur fracture | 329.44 | 13.20 | 318 | 65101 | 37146 | 50502559 |
Pelvic fracture | 319.14 | 13.20 | 194 | 65225 | 11326 | 50528379 |
Hypercalcaemia | 311.18 | 13.20 | 251 | 65168 | 23101 | 50516604 |
Pain in extremity | 277.52 | 13.20 | 878 | 64541 | 271987 | 50267718 |
Fracture | 272.33 | 13.20 | 203 | 65216 | 16630 | 50523075 |
Injection site erythema | 271.95 | 13.20 | 405 | 65014 | 74531 | 50465174 |
Wrist fracture | 261.91 | 13.20 | 171 | 65248 | 11316 | 50528389 |
Back pain | 245.91 | 13.20 | 732 | 64687 | 219298 | 50320407 |
Injection site bruising | 239.98 | 13.20 | 266 | 65153 | 36502 | 50503203 |
Toxicity to various agents | 219.55 | 13.20 | 14 | 65405 | 212485 | 50327220 |
Bone density decreased | 219.19 | 13.20 | 151 | 65268 | 10924 | 50528781 |
Rib fracture | 201.47 | 13.20 | 180 | 65239 | 19041 | 50520664 |
Off label use | 198.53 | 13.20 | 193 | 65226 | 474233 | 50065472 |
Injection site haematoma | 185.90 | 13.20 | 109 | 65310 | 5951 | 50533754 |
Arthralgia | 177.71 | 13.20 | 1069 | 64350 | 437633 | 50102072 |
Drug intolerance | 177.64 | 13.20 | 34 | 65385 | 219070 | 50320635 |
Upper limb fracture | 173.03 | 13.20 | 152 | 65267 | 15721 | 50523984 |
Infusion related reaction | 167.00 | 13.20 | 14 | 65405 | 169543 | 50370162 |
Feeling abnormal | 164.86 | 13.20 | 443 | 64976 | 125049 | 50414656 |
Spinal operation | 164.63 | 13.20 | 102 | 65317 | 6158 | 50533547 |
Injection site pain | 164.43 | 13.20 | 410 | 65009 | 110614 | 50429091 |
Completed suicide | 151.70 | 13.20 | 4 | 65415 | 131885 | 50407820 |
Treatment failure | 148.50 | 13.20 | 7 | 65412 | 137630 | 50402075 |
Neutropenia | 143.57 | 13.20 | 13 | 65406 | 147952 | 50391753 |
Asthenia | 142.95 | 13.20 | 799 | 64620 | 318243 | 50221462 |
Acute kidney injury | 135.01 | 13.20 | 63 | 65356 | 227995 | 50311710 |
Drug hypersensitivity | 134.34 | 13.20 | 79 | 65340 | 250931 | 50288774 |
Lumbar vertebral fracture | 133.97 | 13.20 | 80 | 65339 | 4517 | 50535188 |
Femoral neck fracture | 129.40 | 13.20 | 94 | 65325 | 7396 | 50532309 |
Product dose omission issue | 128.60 | 13.20 | 524 | 64895 | 183314 | 50356391 |
Chronic obstructive pulmonary disease | 124.48 | 13.20 | 237 | 65182 | 53198 | 50486507 |
Nephrolithiasis | 123.58 | 13.20 | 186 | 65233 | 34507 | 50505198 |
Vertebroplasty | 121.41 | 13.20 | 35 | 65384 | 279 | 50539426 |
Synovitis | 119.84 | 13.20 | 11 | 65408 | 123854 | 50415851 |
Therapeutic product effect decreased | 119.35 | 13.20 | 17 | 65402 | 136033 | 50403672 |
Febrile neutropenia | 108.56 | 13.20 | 4 | 65415 | 97663 | 50442042 |
Drug interaction | 107.94 | 13.20 | 62 | 65357 | 199559 | 50340146 |
Bone disorder | 107.65 | 13.20 | 127 | 65292 | 18625 | 50521080 |
Spinal compression fracture | 106.62 | 13.20 | 105 | 65314 | 12551 | 50527154 |
Compression fracture | 104.82 | 13.20 | 75 | 65344 | 5762 | 50533943 |
Glossodynia | 104.80 | 13.20 | 13 | 65406 | 115556 | 50424149 |
Hand deformity | 102.22 | 13.20 | 7 | 65412 | 100192 | 50439513 |
Pyrexia | 100.99 | 13.20 | 213 | 65206 | 379990 | 50159715 |
Foot fracture | 99.03 | 13.20 | 126 | 65293 | 19965 | 50519740 |
Surgery | 97.84 | 13.20 | 155 | 65264 | 30050 | 50509655 |
Product use issue | 96.93 | 13.20 | 36 | 65383 | 149439 | 50390266 |
Thoracic vertebral fracture | 93.72 | 13.20 | 61 | 65358 | 4012 | 50535693 |
Systemic lupus erythematosus | 92.65 | 13.20 | 33 | 65386 | 140589 | 50399116 |
Blood alkaline phosphatase increased | 91.81 | 13.20 | 170 | 65249 | 37356 | 50502349 |
Therapeutic product effect incomplete | 91.61 | 13.20 | 7 | 65412 | 91508 | 50448197 |
Heart rate increased | 90.77 | 13.20 | 262 | 65157 | 76988 | 50462717 |
Product use in unapproved indication | 89.59 | 13.20 | 20 | 65399 | 115799 | 50423906 |
Gait disturbance | 88.27 | 13.20 | 406 | 65013 | 149599 | 50390106 |
Humerus fracture | 87.15 | 13.20 | 75 | 65344 | 7543 | 50532162 |
Palpitations | 79.64 | 13.20 | 286 | 65133 | 94220 | 50445485 |
Hepatic enzyme increased | 79.62 | 13.20 | 39 | 65380 | 137341 | 50402364 |
Thrombocytopenia | 79.06 | 13.20 | 33 | 65386 | 127640 | 50412065 |
Osteitis deformans | 77.81 | 13.20 | 23 | 65396 | 202 | 50539503 |
Disease progression | 77.35 | 13.20 | 15 | 65404 | 95851 | 50443854 |
Myalgia | 77.24 | 13.20 | 342 | 65077 | 123977 | 50415728 |
Ankle fracture | 73.41 | 13.20 | 96 | 65323 | 15626 | 50524079 |
Therapy interrupted | 73.11 | 13.20 | 109 | 65310 | 20043 | 50519662 |
Rheumatoid arthritis | 72.79 | 13.20 | 93 | 65326 | 202457 | 50337248 |
Wound | 67.69 | 13.20 | 26 | 65393 | 105768 | 50433937 |
Vitamin D decreased | 67.59 | 13.20 | 68 | 65351 | 8338 | 50531367 |
Medication error | 67.25 | 13.20 | 146 | 65273 | 35958 | 50503747 |
Patella fracture | 66.89 | 13.20 | 37 | 65382 | 1805 | 50537900 |
Pericarditis | 66.32 | 13.20 | 11 | 65408 | 78678 | 50461027 |
Malignant neoplasm progression | 66 | 13.20 | 6 | 65413 | 68118 | 50471587 |
Rash | 65.51 | 13.20 | 317 | 65102 | 437154 | 50102551 |
Stomatitis | 64.69 | 13.20 | 25 | 65394 | 101319 | 50438386 |
White blood cell count decreased | 63.40 | 13.20 | 36 | 65383 | 116686 | 50423019 |
Cerebrovascular accident | 63.03 | 13.20 | 266 | 65153 | 94414 | 50445291 |
Tibia fracture | 61.49 | 13.20 | 49 | 65370 | 4426 | 50535279 |
Condition aggravated | 60.61 | 13.20 | 190 | 65229 | 296868 | 50242837 |
Lower respiratory tract infection | 59.91 | 13.20 | 24 | 65395 | 95177 | 50444528 |
Hand fracture | 59.43 | 13.20 | 48 | 65371 | 4420 | 50535285 |
Intentional overdose | 59.24 | 13.20 | 6 | 65413 | 62498 | 50477207 |
Lower limb fracture | 58.91 | 13.20 | 82 | 65337 | 14164 | 50525541 |
Drug abuse | 58.71 | 13.20 | 5 | 65414 | 59841 | 50479864 |
Contusion | 57.55 | 13.20 | 292 | 65127 | 111891 | 50427814 |
Recalled product | 57.40 | 13.20 | 30 | 65389 | 1305 | 50538400 |
Diarrhoea | 56.21 | 13.20 | 489 | 64930 | 587987 | 49951718 |
Stress fracture | 55.98 | 13.20 | 56 | 65363 | 6819 | 50532886 |
Leukopenia | 55.67 | 13.20 | 10 | 65409 | 67518 | 50472187 |
Swelling | 53.66 | 13.20 | 112 | 65307 | 200760 | 50338945 |
Nausea | 53.52 | 13.20 | 1239 | 64180 | 704159 | 49835546 |
Platelet count decreased | 51.99 | 13.20 | 33 | 65386 | 100693 | 50439012 |
Cardiac disorder | 49.72 | 13.20 | 145 | 65274 | 42834 | 50496871 |
Blood parathyroid hormone increased | 49.71 | 13.20 | 36 | 65383 | 2818 | 50536887 |
Helicobacter infection | 49.17 | 13.20 | 4 | 65415 | 49698 | 50490007 |
Myocardial infarction | 48.68 | 13.20 | 236 | 65183 | 88791 | 50450914 |
Pancytopenia | 48.45 | 13.20 | 24 | 65395 | 84006 | 50455699 |
Duodenal ulcer perforation | 47.05 | 13.20 | 3 | 65416 | 45608 | 50494097 |
Intentional product use issue | 45.83 | 13.20 | 21 | 65398 | 76897 | 50462808 |
Psoriasis | 45.75 | 13.20 | 16 | 65403 | 68984 | 50470721 |
Breast cancer | 45.17 | 13.20 | 140 | 65279 | 42750 | 50496955 |
Balance disorder | 45.17 | 13.20 | 196 | 65223 | 70394 | 50469311 |
Malaise | 45.02 | 13.20 | 645 | 64774 | 334887 | 50204818 |
Head injury | 44.57 | 13.20 | 97 | 65322 | 23923 | 50515782 |
Anaphylactic reaction | 44.57 | 13.20 | 8 | 65411 | 54047 | 50485658 |
Urine calcium increased | 44.14 | 13.20 | 11 | 65408 | 46 | 50539659 |
Pathological fracture | 44.04 | 13.20 | 52 | 65367 | 7630 | 50532075 |
Fractured sacrum | 44.02 | 13.20 | 28 | 65391 | 1770 | 50537935 |
Nervousness | 43.92 | 13.20 | 105 | 65314 | 27546 | 50512159 |
Therapeutic response decreased | 43.57 | 13.20 | 5 | 65414 | 47226 | 50492479 |
Musculoskeletal discomfort | 43.55 | 13.20 | 73 | 65346 | 14825 | 50524880 |
Calciphylaxis | 43.06 | 13.20 | 32 | 65387 | 2606 | 50537099 |
Hypersensitivity | 42.87 | 13.20 | 139 | 65280 | 215022 | 50324683 |
Hip surgery | 42.85 | 13.20 | 32 | 65387 | 2626 | 50537079 |
Body height decreased | 42.53 | 13.20 | 55 | 65364 | 8853 | 50530852 |
Neutrophil count decreased | 42.14 | 13.20 | 5 | 65414 | 46021 | 50493684 |
Suicide attempt | 41.92 | 13.20 | 8 | 65411 | 51724 | 50487981 |
Peripheral swelling | 41.76 | 13.20 | 132 | 65287 | 205804 | 50333901 |
Joint swelling | 41.28 | 13.20 | 170 | 65249 | 245116 | 50294589 |
Fear | 40.82 | 13.20 | 70 | 65349 | 14479 | 50525226 |
Bone fissure | 40.72 | 13.20 | 13 | 65406 | 151 | 50539554 |
Sinusitis | 39.97 | 13.20 | 102 | 65317 | 170456 | 50369249 |
Incorrect product administration duration | 39.27 | 13.20 | 54 | 65365 | 9221 | 50530484 |
Cervical vertebral fracture | 39.11 | 13.20 | 28 | 65391 | 2152 | 50537553 |
Fracture nonunion | 38.84 | 13.20 | 28 | 65391 | 2176 | 50537529 |
Arrhythmia | 38.53 | 13.20 | 112 | 65307 | 33020 | 50506685 |
Injection site rash | 37.95 | 13.20 | 72 | 65347 | 16105 | 50523600 |
Abdominal pain | 37.73 | 13.20 | 167 | 65252 | 236061 | 50303644 |
Lung neoplasm malignant | 37.67 | 13.20 | 70 | 65349 | 15414 | 50524291 |
Transient ischaemic attack | 37.57 | 13.20 | 109 | 65310 | 32101 | 50507604 |
Breast cancer in situ | 36.82 | 13.20 | 23 | 65396 | 1408 | 50538297 |
Folliculitis | 36.57 | 13.20 | 4 | 65415 | 39221 | 50500484 |
Bradycardia | 36.24 | 13.20 | 19 | 65400 | 64407 | 50475298 |
Neuropathy peripheral | 36.22 | 13.20 | 43 | 65376 | 96714 | 50442991 |
Dyspnoea | 36.17 | 13.20 | 495 | 64924 | 547113 | 49992592 |
Road traffic accident | 36.05 | 13.20 | 90 | 65329 | 24262 | 50515443 |
Alanine aminotransferase increased | 35.56 | 13.20 | 37 | 65382 | 88322 | 50451383 |
Death | 35.43 | 13.20 | 604 | 64815 | 324775 | 50214930 |
Ulna fracture | 35.41 | 13.20 | 20 | 65399 | 1016 | 50538689 |
Wheezing | 35.34 | 13.20 | 18 | 65401 | 62029 | 50477676 |
Hypokalaemia | 35.24 | 13.20 | 37 | 65382 | 87955 | 50451750 |
Hypotension | 34.92 | 13.20 | 171 | 65248 | 235298 | 50304407 |
Hip arthroplasty | 34.55 | 13.20 | 102 | 65317 | 30327 | 50509378 |
Post procedural complication | 33.93 | 13.20 | 66 | 65353 | 15038 | 50524667 |
Osteocalcin increased | 33.91 | 13.20 | 6 | 65413 | 0 | 50539705 |
N-telopeptide urine increased | 33.91 | 13.20 | 6 | 65413 | 0 | 50539705 |
Calcinosis | 33.37 | 13.20 | 24 | 65395 | 1858 | 50537847 |
Fibula fracture | 33.13 | 13.20 | 29 | 65390 | 2983 | 50536722 |
Weight decreased | 32.75 | 13.20 | 433 | 64986 | 220812 | 50318893 |
Device failure | 32.65 | 13.20 | 38 | 65381 | 5490 | 50534215 |
Movement disorder | 32.48 | 13.20 | 71 | 65348 | 17561 | 50522144 |
Injury associated with device | 32.27 | 13.20 | 29 | 65390 | 3088 | 50536617 |
Abdominal discomfort | 32.21 | 13.20 | 172 | 65247 | 231469 | 50308236 |
Blood calcium abnormal | 31.91 | 13.20 | 19 | 65400 | 1067 | 50538638 |
Radius fracture | 31.55 | 13.20 | 29 | 65390 | 3180 | 50536525 |
Pain | 31.16 | 13.20 | 973 | 64446 | 577930 | 49961775 |
Muscular weakness | 31.13 | 13.20 | 220 | 65199 | 94793 | 50444912 |
Blister | 30.87 | 13.20 | 39 | 65380 | 85379 | 50454326 |
Multiple fractures | 30.29 | 13.20 | 40 | 65379 | 6571 | 50533134 |
Loss of consciousness | 29.86 | 13.20 | 234 | 65185 | 104119 | 50435586 |
Accident | 29.80 | 13.20 | 35 | 65384 | 5106 | 50534599 |
Memory impairment | 29.74 | 13.20 | 190 | 65229 | 79170 | 50460535 |
Muscle injury | 29.52 | 13.20 | 6 | 65413 | 37105 | 50502600 |
Atypical femur fracture | 29.38 | 13.20 | 34 | 65385 | 4882 | 50534823 |
Back disorder | 29.09 | 13.20 | 47 | 65372 | 9258 | 50530447 |
Neck pain | 28.86 | 13.20 | 148 | 65271 | 56919 | 50482786 |
Hypercalciuria | 28.83 | 13.20 | 11 | 65408 | 223 | 50539482 |
Suicidal ideation | 28.77 | 13.20 | 18 | 65401 | 55367 | 50484338 |
Multiple sclerosis relapse | 28.41 | 13.20 | 10 | 65409 | 42954 | 50496751 |
Haemoglobin decreased | 28.33 | 13.20 | 78 | 65341 | 127138 | 50412567 |
Hyperparathyroidism | 28.08 | 13.20 | 24 | 65395 | 2390 | 50537315 |
Clavicle fracture | 27.81 | 13.20 | 26 | 65393 | 2913 | 50536792 |
Emphysema | 27.17 | 13.20 | 45 | 65374 | 9048 | 50530657 |
Osteonecrosis | 27.03 | 13.20 | 77 | 65342 | 22440 | 50517265 |
Agitation | 26.84 | 13.20 | 18 | 65401 | 53366 | 50486339 |
Spinal deformity | 26.24 | 13.20 | 16 | 65403 | 938 | 50538767 |
Accidental underdose | 26.06 | 13.20 | 14 | 65405 | 644 | 50539061 |
Breast calcifications | 25.85 | 13.20 | 17 | 65402 | 1138 | 50538567 |
Metabolic acidosis | 25.74 | 13.20 | 9 | 65410 | 38816 | 50500889 |
C-reactive protein increased | 25.46 | 13.20 | 29 | 65390 | 66445 | 50473260 |
Bone marrow failure | 25.29 | 13.20 | 3 | 65416 | 27621 | 50512084 |
Dementia Alzheimer's type | 25.06 | 13.20 | 16 | 65403 | 1018 | 50538687 |
Headache | 24.79 | 13.20 | 842 | 64577 | 505693 | 50034012 |
Calcium ionised increased | 24.67 | 13.20 | 8 | 65411 | 98 | 50539607 |
Vomiting | 24.44 | 13.20 | 434 | 64985 | 460324 | 50079381 |
Bone scan abnormal | 24.32 | 13.20 | 11 | 65408 | 347 | 50539358 |
Facial bones fracture | 24.27 | 13.20 | 25 | 65394 | 3152 | 50536553 |
Joint dislocation | 24.26 | 13.20 | 51 | 65368 | 12282 | 50527423 |
Oxygen saturation decreased | 23.90 | 13.20 | 36 | 65383 | 73212 | 50466493 |
Blood bilirubin increased | 23.84 | 13.20 | 6 | 65413 | 32032 | 50507673 |
Discomfort | 23.72 | 13.20 | 67 | 65352 | 108313 | 50431392 |
Enchondromatosis | 23.53 | 13.20 | 7 | 65412 | 63 | 50539642 |
Hernial eventration | 23.49 | 13.20 | 5 | 65414 | 8 | 50539697 |
Sternal fracture | 23.49 | 13.20 | 20 | 65399 | 1982 | 50537723 |
Colon cancer | 23.32 | 13.20 | 41 | 65378 | 8650 | 50531055 |
Hypoacusis | 23.24 | 13.20 | 69 | 65350 | 20578 | 50519127 |
Bone cancer | 23.05 | 13.20 | 16 | 65403 | 1171 | 50538534 |
Heart rate irregular | 23.04 | 13.20 | 66 | 65353 | 19294 | 50520411 |
Liver function test increased | 22.91 | 13.20 | 3 | 65416 | 25603 | 50514102 |
Angioedema | 22.89 | 13.20 | 10 | 65409 | 37666 | 50502039 |
Vein disorder | 22.74 | 13.20 | 28 | 65391 | 4291 | 50535414 |
Rhabdomyolysis | 22.71 | 13.20 | 11 | 65408 | 39016 | 50500689 |
Osteoporotic fracture | 22.68 | 13.20 | 24 | 65395 | 3121 | 50536584 |
Cementoplasty | 22.61 | 13.20 | 4 | 65415 | 0 | 50539705 |
Ilium fracture | 22.55 | 13.20 | 8 | 65411 | 131 | 50539574 |
Addison's disease | 22.44 | 13.20 | 7 | 65412 | 75 | 50539630 |
Nerve compression | 22.39 | 13.20 | 37 | 65382 | 7425 | 50532280 |
Aspartate aminotransferase increased | 22.08 | 13.20 | 42 | 65377 | 77956 | 50461749 |
Encephalopathy | 22.03 | 13.20 | 8 | 65411 | 33703 | 50506002 |
Breast cancer female | 21.92 | 13.20 | 35 | 65384 | 6827 | 50532878 |
Hallucination, synaesthetic | 21.74 | 13.20 | 6 | 65413 | 40 | 50539665 |
Dysstasia | 21.45 | 13.20 | 61 | 65358 | 17758 | 50521947 |
Visual acuity reduced | 21.44 | 13.20 | 66 | 65353 | 20073 | 50519632 |
Groin pain | 21.38 | 13.20 | 40 | 65379 | 8851 | 50530854 |
Sleep disorder due to general medical condition, insomnia type | 21.35 | 13.20 | 7 | 65412 | 31440 | 50508265 |
Cardio-respiratory arrest | 21.20 | 13.20 | 23 | 65396 | 53869 | 50485836 |
Type 2 diabetes mellitus | 21.08 | 13.20 | 9 | 65410 | 34366 | 50505339 |
Alopecia | 20.95 | 13.20 | 209 | 65210 | 244838 | 50294867 |
General physical health deterioration | 20.77 | 13.20 | 104 | 65315 | 142330 | 50397375 |
Limb discomfort | 20.73 | 13.20 | 74 | 65345 | 24283 | 50515422 |
Hernia hiatus repair | 20.68 | 13.20 | 6 | 65413 | 49 | 50539656 |
Hyperkalaemia | 20.66 | 13.20 | 19 | 65400 | 48070 | 50491635 |
Leukaemia | 20.58 | 13.20 | 24 | 65395 | 3475 | 50536230 |
Drug eruption | 20.56 | 13.20 | 3 | 65416 | 23603 | 50516102 |
Hypervolaemia | 20.53 | 13.20 | 4 | 65415 | 25495 | 50514210 |
Extraskeletal ossification | 20.17 | 13.20 | 7 | 65412 | 107 | 50539598 |
Hepatic cancer | 20.16 | 13.20 | 23 | 65396 | 3252 | 50536453 |
Drug withdrawal syndrome | 20.06 | 13.20 | 4 | 65415 | 25077 | 50514628 |
Plasma cell myeloma | 20.05 | 13.20 | 87 | 65332 | 31235 | 50508470 |
Vertigo | 19.97 | 13.20 | 125 | 65294 | 51707 | 50487998 |
Prosthesis implantation | 19.79 | 13.20 | 6 | 65413 | 58 | 50539647 |
Serotonin syndrome | 19.64 | 13.20 | 4 | 65415 | 24709 | 50514996 |
Influenza | 19.46 | 13.20 | 189 | 65230 | 89349 | 50450356 |
Complication associated with device | 19.46 | 13.20 | 52 | 65367 | 14603 | 50525102 |
Injection site irritation | 19.44 | 13.20 | 26 | 65393 | 4324 | 50535381 |
Transaminases increased | 19.23 | 13.20 | 6 | 65413 | 27818 | 50511887 |
Hyponatraemia | 19.20 | 13.20 | 62 | 65357 | 96077 | 50443628 |
Constipation | 19.18 | 13.20 | 342 | 65077 | 185366 | 50354339 |
Gammopathy | 19.17 | 13.20 | 7 | 65412 | 125 | 50539580 |
Productive cough | 19.10 | 13.20 | 24 | 65395 | 52670 | 50487035 |
Irritable bowel syndrome | 19.10 | 13.20 | 23 | 65396 | 51418 | 50488287 |
Arthropathy | 18.87 | 13.20 | 123 | 65296 | 157783 | 50381922 |
Pleural effusion | 18.84 | 13.20 | 49 | 65370 | 81405 | 50458300 |
Oedema | 18.82 | 13.20 | 39 | 65380 | 70142 | 50469563 |
Tetany | 18.62 | 13.20 | 16 | 65403 | 1605 | 50538100 |
Cough | 18.51 | 13.20 | 211 | 65208 | 241053 | 50298652 |
Neoplasm malignant | 18.46 | 13.20 | 70 | 65349 | 23645 | 50516060 |
Parkinson's disease | 18.40 | 13.20 | 14 | 65405 | 1181 | 50538524 |
Musculoskeletal chest pain | 18.23 | 13.20 | 59 | 65360 | 18427 | 50521278 |
Intestinal obstruction | 18.22 | 13.20 | 75 | 65344 | 26308 | 50513397 |
Hepatitis | 18.10 | 13.20 | 9 | 65410 | 31444 | 50508261 |
Injection site streaking | 18.04 | 13.20 | 5 | 65414 | 34 | 50539671 |
Rash maculo-papular | 17.96 | 13.20 | 6 | 65413 | 26635 | 50513070 |
Drug ineffective for unapproved indication | 17.87 | 13.20 | 3 | 65416 | 21278 | 50518427 |
Liver injury | 17.78 | 13.20 | 5 | 65414 | 24801 | 50514904 |
Sleep disorder due to a general medical condition | 17.53 | 13.20 | 33 | 65386 | 7338 | 50532367 |
Cystitis | 17.50 | 13.20 | 108 | 65311 | 44456 | 50495249 |
Fracture malunion | 17.33 | 13.20 | 7 | 65412 | 166 | 50539539 |
Sedation | 17.25 | 13.20 | 9 | 65410 | 30601 | 50509104 |
Rehabilitation therapy | 17.24 | 13.20 | 14 | 65405 | 1299 | 50538406 |
Hepatocellular injury | 17.22 | 13.20 | 6 | 65413 | 25941 | 50513764 |
Spinal disorder | 17.20 | 13.20 | 35 | 65384 | 8235 | 50531470 |
Product distribution issue | 17.18 | 13.20 | 11 | 65408 | 703 | 50539002 |
Infection | 17.17 | 13.20 | 142 | 65277 | 172812 | 50366893 |
Growing pains | 17.08 | 13.20 | 4 | 65415 | 12 | 50539693 |
Posture abnormal | 16.98 | 13.20 | 17 | 65402 | 2072 | 50537633 |
Basosquamous carcinoma of skin | 16.96 | 13.20 | 3 | 65416 | 0 | 50539705 |
Wrong product stored | 16.96 | 13.20 | 3 | 65416 | 0 | 50539705 |
Pulmonary arterial hypertension | 16.76 | 13.20 | 3 | 65416 | 20316 | 50519389 |
Joint arthroplasty | 16.75 | 13.20 | 17 | 65402 | 2106 | 50537599 |
Blood creatinine increased | 16.72 | 13.20 | 47 | 65372 | 76113 | 50463592 |
Joint injury | 16.70 | 13.20 | 64 | 65355 | 21725 | 50517980 |
Upper respiratory tract infection | 16.53 | 13.20 | 38 | 65381 | 65860 | 50473845 |
Face injury | 16.31 | 13.20 | 19 | 65400 | 2747 | 50536958 |
Injection site discolouration | 16.31 | 13.20 | 31 | 65388 | 6943 | 50532762 |
Liver function test abnormal | 16.27 | 13.20 | 20 | 65399 | 44319 | 50495386 |
Dystrophic calcification | 16.19 | 13.20 | 6 | 65413 | 112 | 50539593 |
Cataract operation | 16.01 | 13.20 | 23 | 65396 | 4088 | 50535617 |
Gait inability | 15.99 | 13.20 | 92 | 65327 | 36935 | 50502770 |
Parathyroid tumour benign | 15.98 | 13.20 | 10 | 65409 | 614 | 50539091 |
Spinal stenosis | 15.94 | 13.20 | 46 | 65373 | 13504 | 50526201 |
Coma | 15.77 | 13.20 | 31 | 65388 | 56848 | 50482857 |
Urinary bladder polyp | 15.51 | 13.20 | 5 | 65414 | 60 | 50539645 |
Jaw disorder | 15.50 | 13.20 | 25 | 65394 | 4918 | 50534787 |
International normalised ratio increased | 15.28 | 13.20 | 20 | 65399 | 43132 | 50496573 |
Extrasystoles | 15.22 | 13.20 | 24 | 65395 | 4631 | 50535074 |
Septic shock | 15.14 | 13.20 | 32 | 65387 | 57143 | 50482562 |
Scoliosis | 15.09 | 13.20 | 29 | 65390 | 6547 | 50533158 |
Spinal fusion surgery | 15.05 | 13.20 | 22 | 65397 | 3973 | 50535732 |
Cardiac failure congestive | 14.99 | 13.20 | 171 | 65248 | 84211 | 50455494 |
Skeletal injury | 14.88 | 13.20 | 12 | 65407 | 1102 | 50538603 |
Traumatic shock | 14.88 | 13.20 | 3 | 65416 | 3 | 50539702 |
Acetabulum fracture | 14.85 | 13.20 | 7 | 65412 | 243 | 50539462 |
Loss of personal independence in daily activities | 14.81 | 13.20 | 44 | 65375 | 70006 | 50469699 |
Cardiac flutter | 14.75 | 13.20 | 20 | 65399 | 3370 | 50536335 |
Depressed level of consciousness | 14.68 | 13.20 | 28 | 65391 | 51925 | 50487780 |
Neoplasm | 14.67 | 13.20 | 27 | 65392 | 5901 | 50533804 |
Psychotic disorder | 14.55 | 13.20 | 5 | 65414 | 21807 | 50517898 |
Wrong technique in device usage process | 14.53 | 13.20 | 17 | 65402 | 2469 | 50537236 |
Lymphocyte count decreased | 14.44 | 13.20 | 8 | 65411 | 26299 | 50513406 |
Knee operation | 14.40 | 13.20 | 24 | 65395 | 4849 | 50534856 |
Pain in jaw | 14.39 | 13.20 | 92 | 65327 | 38336 | 50501369 |
Multiple organ dysfunction syndrome | 14.33 | 13.20 | 27 | 65392 | 50310 | 50489395 |
Pseudarthrosis | 14.19 | 13.20 | 8 | 65411 | 405 | 50539300 |
Dyspnoea exertional | 14.14 | 13.20 | 28 | 65391 | 51205 | 50488500 |
Cytomegalovirus infection | 14.08 | 13.20 | 3 | 65416 | 17959 | 50521746 |
Mass | 14.04 | 13.20 | 41 | 65378 | 12116 | 50527589 |
Manufacturing product shipping issue | 14.03 | 13.20 | 5 | 65414 | 83 | 50539622 |
Kyphosis | 13.93 | 13.20 | 16 | 65403 | 2279 | 50537426 |
Blood lactate dehydrogenase increased | 13.92 | 13.20 | 4 | 65415 | 19558 | 50520147 |
Pulmonary embolism | 13.85 | 13.20 | 76 | 65343 | 101628 | 50438077 |
Hyperglycaemia | 13.81 | 13.20 | 16 | 65403 | 36389 | 50503316 |
Limb crushing injury | 13.80 | 13.20 | 6 | 65413 | 172 | 50539533 |
N-telopeptide urine decreased | 13.67 | 13.20 | 3 | 65416 | 6 | 50539699 |
Oestrogen receptor assay positive | 13.67 | 13.20 | 8 | 65411 | 435 | 50539270 |
Cardiac pacemaker insertion | 13.59 | 13.20 | 20 | 65399 | 3633 | 50536072 |
Arterial disorder | 13.57 | 13.20 | 11 | 65408 | 1018 | 50538687 |
Intentional product misuse | 13.47 | 13.20 | 105 | 65314 | 46629 | 50493076 |
Tremor | 13.45 | 13.20 | 216 | 65203 | 114687 | 50425018 |
Bone graft | 13.37 | 13.20 | 10 | 65409 | 822 | 50538883 |
Ascites | 13.35 | 13.20 | 16 | 65403 | 35845 | 50503860 |
Angina pectoris | 13.29 | 13.20 | 68 | 65351 | 26120 | 50513585 |
MedDRA adverse event term | Likelihood ratio | Likelihood ratio threshold | Patients taking drug having adverse event | Patients taking drug not having adverse event | Patients not taking drug having adverse event | Patients not taking drug not having adverse event |
---|---|---|---|---|---|---|
Hip fracture | 124.07 | 21.92 | 54 | 5820 | 10438 | 29558215 |
Hospitalisation | 118.74 | 21.92 | 87 | 5787 | 45901 | 29522752 |
Product complaint | 113.22 | 21.92 | 42 | 5832 | 5363 | 29563290 |
Bone pain | 89.79 | 21.92 | 52 | 5822 | 18400 | 29550253 |
Fall | 88.06 | 21.92 | 139 | 5735 | 177039 | 29391614 |
Spinal fracture | 75.40 | 21.92 | 33 | 5841 | 6453 | 29562200 |
Therapy cessation | 68.34 | 21.92 | 40 | 5834 | 14422 | 29554231 |
Spinal operation | 62.69 | 21.92 | 22 | 5852 | 2392 | 29566261 |
Bone density decreased | 54.14 | 21.92 | 18 | 5856 | 1662 | 29566991 |
Muscle spasms | 45.22 | 21.92 | 60 | 5814 | 65022 | 29503631 |
Back pain | 43.53 | 21.92 | 75 | 5799 | 102209 | 29466444 |
Arthralgia | 42.84 | 21.92 | 89 | 5785 | 139528 | 29429125 |
Vertebroplasty | 41.83 | 21.92 | 7 | 5867 | 26 | 29568627 |
Femur fracture | 40.21 | 21.92 | 22 | 5852 | 6969 | 29561684 |
Death | 39.77 | 21.92 | 153 | 5721 | 341931 | 29226722 |
Pain in extremity | 38.15 | 21.92 | 74 | 5800 | 110359 | 29458294 |
Thoracic vertebral fracture | 37.29 | 21.92 | 13 | 5861 | 1385 | 29567268 |
Blood calcium increased | 36.18 | 21.92 | 16 | 5858 | 3203 | 29565450 |
Injection site pain | 35.96 | 21.92 | 38 | 5836 | 32408 | 29536245 |
Injection site erythema | 32.80 | 21.92 | 25 | 5849 | 13931 | 29554722 |
Dizziness | 31.76 | 21.92 | 96 | 5778 | 189588 | 29379065 |
Acute kidney injury | 31.74 | 21.92 | 7 | 5867 | 265260 | 29303393 |
Injection site haemorrhage | 31.41 | 21.92 | 20 | 5854 | 8366 | 29560287 |
Fracture | 29.26 | 21.92 | 17 | 5857 | 6036 | 29562617 |
Pneumonia | 28.40 | 21.92 | 132 | 5742 | 320040 | 29248613 |
Pain | 27.96 | 21.92 | 86 | 5788 | 171346 | 29397307 |
Chronic obstructive pulmonary disease | 27.25 | 21.92 | 37 | 5837 | 40918 | 29527735 |
Atypical femur fracture | 26.64 | 21.92 | 7 | 5867 | 284 | 29568369 |
Injection site bruising | 25.74 | 21.92 | 17 | 5857 | 7563 | 29561090 |
Osteoporotic fracture | 25.61 | 21.92 | 9 | 5865 | 982 | 29567671 |
Incorrect product administration duration | 24.02 | 21.92 | 13 | 5861 | 4028 | 29564625 |
Upper limb fracture | 23.99 | 21.92 | 13 | 5861 | 4038 | 29564615 |
Product storage error | 23.16 | 21.92 | 15 | 5859 | 6455 | 29562198 |
MedDRA adverse event term | Likelihood ratio | Likelihood ratio threshold | Patients taking drug having adverse event | Patients taking drug not having adverse event | Patients not taking drug having adverse event | Patients not taking drug not having adverse event |
---|---|---|---|---|---|---|
Product complaint | 1530.79 | 14.19 | 486 | 41769 | 11468 | 64445009 |
Fall | 743.81 | 14.19 | 1121 | 41134 | 415705 | 64040772 |
Blood calcium increased | 608.63 | 14.19 | 224 | 42031 | 8318 | 64448159 |
Bone pain | 492.82 | 14.19 | 335 | 41920 | 47237 | 64409240 |
Product storage error | 419.96 | 14.19 | 195 | 42060 | 13123 | 64443354 |
Injection site haemorrhage | 411.62 | 14.19 | 234 | 42021 | 24044 | 64432433 |
Hip fracture | 403.32 | 14.19 | 240 | 42015 | 26859 | 64429618 |
Muscle spasms | 390.29 | 14.19 | 471 | 41784 | 140552 | 64315925 |
Spinal fracture | 389.78 | 14.19 | 193 | 42062 | 14981 | 64441496 |
Therapy cessation | 310.92 | 14.19 | 218 | 42037 | 32271 | 64424206 |
Dizziness | 293.73 | 14.19 | 775 | 41480 | 429388 | 64027089 |
Injection site erythema | 290.48 | 14.19 | 291 | 41964 | 70509 | 64385968 |
Injection site bruising | 249.68 | 14.19 | 200 | 42055 | 36173 | 64420304 |
Hypercalcaemia | 229.05 | 14.19 | 179 | 42076 | 31237 | 64425240 |
Femur fracture | 226.46 | 14.19 | 184 | 42071 | 33951 | 64422526 |
Pain in extremity | 221.80 | 14.19 | 561 | 41694 | 302524 | 64153953 |
Back pain | 219.57 | 14.19 | 497 | 41758 | 249674 | 64206803 |
Wrist fracture | 201.33 | 14.19 | 108 | 42147 | 9893 | 64446584 |
Drug ineffective | 197.10 | 14.19 | 158 | 42097 | 840089 | 63616388 |
Toxicity to various agents | 193.94 | 14.19 | 11 | 42244 | 363502 | 64092975 |
Pelvic fracture | 184.87 | 14.19 | 104 | 42151 | 10459 | 64446018 |
Arthralgia | 180.59 | 14.19 | 667 | 41588 | 441593 | 64014884 |
Injection site pain | 178.12 | 14.19 | 286 | 41969 | 111122 | 64345355 |
Bone density decreased | 174.21 | 14.19 | 98 | 42157 | 9854 | 64446623 |
Hospitalisation | 172.49 | 14.19 | 229 | 42026 | 74978 | 64381499 |
Acute kidney injury | 167.44 | 14.19 | 44 | 42211 | 449196 | 64007281 |
Feeling abnormal | 166.36 | 14.19 | 307 | 41948 | 133295 | 64323182 |
Spinal operation | 157.43 | 14.19 | 78 | 42177 | 6055 | 64450422 |
Upper limb fracture | 140.41 | 14.19 | 99 | 42156 | 14767 | 64441710 |
Fracture | 132.66 | 14.19 | 105 | 42150 | 18650 | 64437827 |
Neutropenia | 131.67 | 14.19 | 6 | 42249 | 239618 | 64216859 |
Completed suicide | 128.85 | 14.19 | 4 | 42251 | 224410 | 64232067 |
Vertebroplasty | 125.78 | 14.19 | 30 | 42225 | 226 | 64456251 |
Rib fracture | 125.55 | 14.19 | 113 | 42142 | 23925 | 64432552 |
Femoral neck fracture | 121.28 | 14.19 | 74 | 42181 | 8650 | 64447827 |
Product dose omission issue | 117.46 | 14.19 | 336 | 41919 | 194411 | 64262066 |
Therapy interrupted | 110.22 | 14.19 | 97 | 42158 | 19939 | 64436538 |
Lumbar vertebral fracture | 104.01 | 14.19 | 57 | 42198 | 5445 | 64451032 |
Off label use | 99.23 | 14.19 | 164 | 42091 | 632642 | 63823835 |
Drug interaction | 95.11 | 14.19 | 60 | 42195 | 362023 | 64094454 |
Thoracic vertebral fracture | 93.97 | 14.19 | 50 | 42205 | 4503 | 64451974 |
Spinal compression fracture | 84.22 | 14.19 | 73 | 42182 | 14702 | 64441775 |
Foot fracture | 82.52 | 14.19 | 79 | 42176 | 18078 | 64438399 |
Asthenia | 80.98 | 14.19 | 518 | 41737 | 427526 | 64028951 |
Nephrolithiasis | 80.73 | 14.19 | 120 | 42135 | 43563 | 64412914 |
Pyrexia | 77.48 | 14.19 | 156 | 42099 | 558488 | 63897989 |
Pain | 73.27 | 14.19 | 615 | 41640 | 552896 | 63903581 |
Product use in unapproved indication | 72.26 | 14.19 | 14 | 42241 | 176604 | 64279873 |
Thrombocytopenia | 69.18 | 14.19 | 30 | 42225 | 223771 | 64232706 |
Palpitations | 67.54 | 14.19 | 185 | 42070 | 104303 | 64352174 |
Humerus fracture | 66.43 | 14.19 | 49 | 42206 | 7836 | 64448641 |
Nausea | 65.78 | 14.19 | 794 | 41461 | 785006 | 63671471 |
Infusion related reaction | 65.28 | 14.19 | 14 | 42241 | 164453 | 64292024 |
Drug abuse | 64.77 | 14.19 | 6 | 42249 | 132368 | 64324109 |
Drug intolerance | 63.39 | 14.19 | 22 | 42233 | 187970 | 64268507 |
Blood alkaline phosphatase increased | 60.94 | 14.19 | 122 | 42133 | 56157 | 64400320 |
Contusion | 60.43 | 14.19 | 188 | 42067 | 113777 | 64342700 |
Heart rate increased | 60.12 | 14.19 | 171 | 42084 | 98504 | 64357973 |
Disease progression | 58.44 | 14.19 | 11 | 42244 | 141669 | 64314808 |
Atypical femur fracture | 58.10 | 14.19 | 37 | 42218 | 4661 | 64451816 |
Treatment failure | 57.95 | 14.19 | 5 | 42250 | 116811 | 64339666 |
Osteitis deformans | 57.08 | 14.19 | 15 | 42240 | 174 | 64456303 |
Hand fracture | 56.85 | 14.19 | 37 | 42218 | 4837 | 64451640 |
Compression fracture | 55.92 | 14.19 | 39 | 42216 | 5713 | 64450764 |
Chronic obstructive pulmonary disease | 53.27 | 14.19 | 133 | 42122 | 70915 | 64385562 |
Malignant neoplasm progression | 52.93 | 14.19 | 6 | 42249 | 112865 | 64343612 |
Body height decreased | 52.78 | 14.19 | 42 | 42213 | 7512 | 64448965 |
Gait disturbance | 52.71 | 14.19 | 238 | 42017 | 171917 | 64284560 |
Pathological fracture | 52.35 | 14.19 | 45 | 42210 | 8960 | 64447517 |
Calciphylaxis | 50.98 | 14.19 | 30 | 42225 | 3282 | 64453195 |
Therapeutic product effect incomplete | 49.81 | 14.19 | 5 | 42250 | 103477 | 64353000 |
Bone disorder | 49.54 | 14.19 | 58 | 42197 | 16701 | 64439776 |
Surgery | 48.57 | 14.19 | 75 | 42180 | 28138 | 64428339 |
Synovitis | 47.14 | 14.19 | 5 | 42250 | 99085 | 64357392 |
Lower limb fracture | 47.08 | 14.19 | 51 | 42204 | 13494 | 64442983 |
Urine calcium increased | 45.87 | 14.19 | 11 | 42244 | 85 | 64456392 |
Tibia fracture | 45.73 | 14.19 | 32 | 42223 | 4713 | 64451764 |
Hypotension | 45.69 | 14.19 | 115 | 42140 | 380859 | 64075618 |
Headache | 45.44 | 14.19 | 538 | 41717 | 528929 | 63927548 |
Patella fracture | 43.28 | 14.19 | 21 | 42234 | 1557 | 64454920 |
Stress fracture | 43.04 | 14.19 | 33 | 42222 | 5591 | 64450886 |
Diarrhoea | 42.71 | 14.19 | 288 | 41967 | 722416 | 63734061 |
Nervousness | 41.95 | 14.19 | 72 | 42183 | 29484 | 64426993 |
Breast cancer | 41.37 | 14.19 | 71 | 42184 | 29077 | 64427400 |
Neck pain | 40.79 | 14.19 | 110 | 42145 | 61423 | 64395054 |
Pancytopenia | 40.02 | 14.19 | 22 | 42233 | 143287 | 64313190 |
Therapeutic product effect decreased | 39.74 | 14.19 | 13 | 42242 | 115338 | 64341139 |
Leukopenia | 39.39 | 14.19 | 9 | 42246 | 101233 | 64355244 |
Intentional overdose | 39.25 | 14.19 | 6 | 42249 | 89938 | 64366539 |
Myalgia | 39.01 | 14.19 | 206 | 42049 | 158411 | 64298066 |
Platelet count decreased | 38.47 | 14.19 | 32 | 42223 | 167679 | 64288798 |
Musculoskeletal discomfort | 37.94 | 14.19 | 50 | 42205 | 16227 | 64440250 |
Bradycardia | 37.87 | 14.19 | 15 | 42240 | 118204 | 64338273 |
Injection site rash | 37.69 | 14.19 | 49 | 42206 | 15693 | 64440784 |
Blood parathyroid hormone increased | 37.07 | 14.19 | 24 | 42231 | 3110 | 64453367 |
Stomatitis | 36.63 | 14.19 | 13 | 42242 | 109592 | 64346885 |
White blood cell count decreased | 36.34 | 14.19 | 30 | 42225 | 157807 | 64298670 |
Post procedural complication | 35.69 | 14.19 | 56 | 42199 | 21297 | 64435180 |
Cerebrovascular accident | 35.42 | 14.19 | 181 | 42074 | 137402 | 64319075 |
Drug hypersensitivity | 34.96 | 14.19 | 64 | 42191 | 237751 | 64218726 |
Radius fracture | 34.30 | 14.19 | 23 | 42232 | 3161 | 64453316 |
Neutrophil count decreased | 34.03 | 14.19 | 5 | 42250 | 77191 | 64379286 |
Ankle fracture | 34.00 | 14.19 | 45 | 42210 | 14665 | 64441812 |
Fracture nonunion | 32.82 | 14.19 | 17 | 42238 | 1449 | 64455028 |
Medication error | 32.79 | 14.19 | 89 | 42166 | 49877 | 64406600 |
Blood calcium abnormal | 32.33 | 14.19 | 16 | 42239 | 1238 | 64455239 |
Injury associated with device | 31.67 | 14.19 | 21 | 42234 | 2832 | 64453645 |
Breast cancer in situ | 31.36 | 14.19 | 14 | 42241 | 858 | 64455619 |
Multiple fractures | 30.75 | 14.19 | 28 | 42227 | 6012 | 64450465 |
Suicide attempt | 30.39 | 14.19 | 5 | 42250 | 71002 | 64385475 |
Bone scan abnormal | 30.18 | 14.19 | 9 | 42246 | 170 | 64456307 |
Product use issue | 30.06 | 14.19 | 33 | 42222 | 151682 | 64304795 |
Fractured sacrum | 29.88 | 14.19 | 16 | 42239 | 1459 | 64455018 |
Cervical vertebral fracture | 29.88 | 14.19 | 21 | 42234 | 3114 | 64453363 |
Ulna fracture | 29.58 | 14.19 | 14 | 42241 | 982 | 64455495 |
Anaphylactic reaction | 29.02 | 14.19 | 5 | 42250 | 68659 | 64387818 |
Hyperkalaemia | 29.00 | 14.19 | 15 | 42240 | 101114 | 64355363 |
Rhabdomyolysis | 28.79 | 14.19 | 12 | 42243 | 91714 | 64364763 |
Lower respiratory tract infection | 28.71 | 14.19 | 13 | 42242 | 94601 | 64361876 |
Balance disorder | 28.69 | 14.19 | 120 | 42135 | 83806 | 64372671 |
Agitation | 28.65 | 14.19 | 11 | 42244 | 88356 | 64368121 |
Hepatic enzyme increased | 28.33 | 14.19 | 26 | 42229 | 129917 | 64326560 |
Hand deformity | 27.82 | 14.19 | 4 | 42251 | 62767 | 64393710 |
Osteocalcin increased | 27.72 | 14.19 | 5 | 42250 | 6 | 64456471 |
Recalled product | 27.54 | 14.19 | 13 | 42242 | 906 | 64455571 |
Osteoporotic fracture | 27.29 | 14.19 | 21 | 42234 | 3577 | 64452900 |
Complication associated with device | 27.24 | 14.19 | 41 | 42214 | 15039 | 64441438 |
Breast cancer female | 26.66 | 14.19 | 24 | 42231 | 5079 | 64451398 |
Memory impairment | 26.60 | 14.19 | 119 | 42136 | 85563 | 64370914 |
Metabolic acidosis | 26.25 | 14.19 | 7 | 42248 | 70951 | 64385526 |
Cardio-respiratory arrest | 26.19 | 14.19 | 16 | 42239 | 98377 | 64358100 |
Calcium ionised increased | 26.12 | 14.19 | 8 | 42247 | 166 | 64456311 |
Incorrect product administration duration | 25.94 | 14.19 | 32 | 42223 | 9726 | 64446751 |
Hypercalciuria | 25.91 | 14.19 | 10 | 42245 | 423 | 64456054 |
Product distribution issue | 25.57 | 14.19 | 12 | 42243 | 826 | 64455651 |
Calcinosis | 25.44 | 14.19 | 16 | 42239 | 1972 | 64454505 |
Vitamin D decreased | 25.08 | 14.19 | 28 | 42227 | 7659 | 64448818 |
Neuropathy peripheral | 25.05 | 14.19 | 24 | 42231 | 117501 | 64338976 |
Multiple organ dysfunction syndrome | 24.96 | 14.19 | 18 | 42237 | 101395 | 64355082 |
Anaemia | 24.81 | 14.19 | 146 | 42109 | 378534 | 64077943 |
Injection site irritation | 24.77 | 14.19 | 19 | 42236 | 3221 | 64453256 |
Hallucination, synaesthetic | 24.62 | 14.19 | 6 | 42249 | 50 | 64456427 |
Device failure | 24.42 | 14.19 | 24 | 42231 | 5668 | 64450809 |
Dystrophic calcification | 24.06 | 14.19 | 7 | 42248 | 121 | 64456356 |
Road traffic accident | 23.50 | 14.19 | 58 | 42197 | 30687 | 64425790 |
Pericarditis | 23.45 | 14.19 | 6 | 42249 | 62510 | 64393967 |
Encephalopathy | 23.34 | 14.19 | 5 | 42250 | 58814 | 64397663 |
Cementoplasty | 23.09 | 14.19 | 4 | 42251 | 3 | 64456474 |
Vertigo | 23.07 | 14.19 | 88 | 42167 | 58923 | 64397554 |
Hip arthroplasty | 22.76 | 14.19 | 46 | 42209 | 21305 | 64435172 |
Dyspnoea | 22.72 | 14.19 | 333 | 41922 | 718341 | 63738136 |
Bone fissure | 22.69 | 14.19 | 7 | 42248 | 149 | 64456328 |
Alanine aminotransferase increased | 22.65 | 14.19 | 35 | 42220 | 138996 | 64317481 |
Fear | 22.15 | 14.19 | 44 | 42211 | 20127 | 64436350 |
Weight decreased | 22.11 | 14.19 | 285 | 41970 | 285454 | 64171023 |
Intentional product use issue | 22.10 | 14.19 | 18 | 42237 | 95346 | 64361131 |
Wheezing | 21.59 | 14.19 | 13 | 42242 | 80566 | 64375911 |
Osteonecrosis | 21.31 | 14.19 | 53 | 42202 | 28176 | 64428301 |
Sternal fracture | 21.30 | 14.19 | 15 | 42240 | 2232 | 64454245 |
Dementia Alzheimer's type | 20.77 | 14.19 | 11 | 42244 | 981 | 64455496 |
Injection site discolouration | 20.66 | 14.19 | 24 | 42231 | 6851 | 64449626 |
Depressed level of consciousness | 20.64 | 14.19 | 14 | 42241 | 81422 | 64375055 |
Gammopathy | 20.45 | 14.19 | 7 | 42248 | 209 | 64456268 |
Enchondromatosis | 20.38 | 14.19 | 5 | 42250 | 43 | 64456434 |
Hip surgery | 20.01 | 14.19 | 15 | 42240 | 2458 | 64454019 |
Urinary bladder polyp | 19.93 | 14.19 | 7 | 42248 | 226 | 64456251 |
Hypokalaemia | 19.56 | 14.19 | 31 | 42224 | 121872 | 64334605 |
Colon cancer | 19.36 | 14.19 | 32 | 42223 | 12707 | 64443770 |
Lung neoplasm malignant | 19.16 | 14.19 | 43 | 42212 | 21405 | 64435072 |
Fibula fracture | 19.11 | 14.19 | 16 | 42239 | 3072 | 64453405 |
Head injury | 19.10 | 14.19 | 56 | 42199 | 32786 | 64423691 |
Prosthesis implantation | 19.03 | 14.19 | 5 | 42250 | 58 | 64456419 |
Sepsis | 18.95 | 14.19 | 82 | 42173 | 230259 | 64226218 |
Growing pains | 18.52 | 14.19 | 4 | 42251 | 18 | 64456459 |
C-reactive protein increased | 18.40 | 14.19 | 21 | 42234 | 94888 | 64361589 |
Arrhythmia | 18.32 | 14.19 | 76 | 42179 | 52868 | 64403609 |
Parkinson's disease | 18.30 | 14.19 | 12 | 42243 | 1589 | 64454888 |
Injection site urticaria | 18.24 | 14.19 | 29 | 42226 | 11152 | 64445325 |
Hyperparathyroidism | 18.12 | 14.19 | 15 | 42240 | 2837 | 64453640 |
Cardiac arrest | 18.04 | 14.19 | 47 | 42208 | 154017 | 64302460 |
Extraskeletal ossification | 18.03 | 14.19 | 5 | 42250 | 72 | 64456405 |
Musculoskeletal chest pain | 18.01 | 14.19 | 42 | 42213 | 21437 | 64435040 |
Wrong technique in device usage process | 17.98 | 14.19 | 15 | 42240 | 2867 | 64453610 |
Angioedema | 17.98 | 14.19 | 9 | 42246 | 61812 | 64394665 |
Glossodynia | 17.96 | 14.19 | 10 | 42245 | 64686 | 64391791 |
Fatigue | 17.91 | 14.19 | 628 | 41627 | 748102 | 63708375 |
Groin pain | 17.83 | 14.19 | 29 | 42226 | 11364 | 64445113 |
Joint dislocation | 17.69 | 14.19 | 29 | 42226 | 11436 | 64445041 |
Oxygen saturation decreased | 17.43 | 14.19 | 27 | 42228 | 107149 | 64349328 |
Leukaemia | 17.41 | 14.19 | 19 | 42236 | 5069 | 64451408 |
Blood bilirubin increased | 17.31 | 14.19 | 8 | 42247 | 57545 | 64398932 |
General physical health deterioration | 17.29 | 14.19 | 72 | 42183 | 204353 | 64252124 |
Tetany | 17.18 | 14.19 | 13 | 42242 | 2159 | 64454318 |
Vein disorder | 17.10 | 14.19 | 17 | 42238 | 4070 | 64452407 |
Breast calcifications | 17.01 | 14.19 | 9 | 42246 | 801 | 64455676 |
Cardiac disorder | 16.93 | 14.19 | 77 | 42178 | 55739 | 64400738 |
Unresponsive to stimuli | 16.79 | 14.19 | 6 | 42249 | 50387 | 64406090 |
Pneumonitis | 16.78 | 14.19 | 6 | 42249 | 50359 | 64406118 |
Manufacturing product shipping issue | 16.74 | 14.19 | 5 | 42250 | 95 | 64456382 |
Rash maculo-papular | 16.72 | 14.19 | 5 | 42250 | 47021 | 64409456 |
Gastrointestinal haemorrhage | 16.56 | 14.19 | 39 | 42216 | 132273 | 64324204 |
Clavicle fracture | 16.44 | 14.19 | 16 | 42239 | 3733 | 64452744 |
Back disorder | 16.42 | 14.19 | 26 | 42229 | 9964 | 64446513 |
Bone cancer | 16.32 | 14.19 | 11 | 42244 | 1524 | 64454953 |
Neoplasm malignant | 16.22 | 14.19 | 44 | 42211 | 24644 | 64431833 |
Suicidal ideation | 16.13 | 14.19 | 12 | 42243 | 66530 | 64389947 |
Delirium | 16.11 | 14.19 | 13 | 42242 | 69181 | 64387296 |
Hyperglycaemia | 16.10 | 14.19 | 10 | 42245 | 60958 | 64395519 |
Muscle disorder | 16.09 | 14.19 | 18 | 42237 | 4933 | 64451544 |
Pleural effusion | 16.08 | 14.19 | 37 | 42218 | 126522 | 64329955 |
Hyponatraemia | 16.07 | 14.19 | 47 | 42208 | 148292 | 64308185 |
Aspartate aminotransferase increased | 16.06 | 14.19 | 34 | 42221 | 119754 | 64336723 |
Atypical fracture | 15.82 | 14.19 | 8 | 42247 | 648 | 64455829 |
Helicobacter infection | 15.76 | 14.19 | 3 | 42252 | 38359 | 64418118 |
Laryngeal pain | 15.73 | 14.19 | 19 | 42236 | 5649 | 64450828 |
Wrong product stored | 15.70 | 14.19 | 3 | 42252 | 6 | 64456471 |
Haemoglobin decreased | 15.70 | 14.19 | 70 | 42185 | 194993 | 64261484 |
Agranulocytosis | 15.69 | 14.19 | 3 | 42252 | 38226 | 64418251 |
N-telopeptide urine increased | 15.50 | 14.19 | 4 | 42251 | 43 | 64456434 |
Limb discomfort | 15.48 | 14.19 | 46 | 42209 | 27129 | 64429348 |
Blood creatinine increased | 15.46 | 14.19 | 42 | 42213 | 135740 | 64320737 |
Hypoglycaemia | 15.25 | 14.19 | 22 | 42233 | 89870 | 64366607 |
Breast enlargement | 15.19 | 14.19 | 10 | 42245 | 1332 | 64455145 |
Intervertebral disc compression | 15.15 | 14.19 | 9 | 42246 | 1002 | 64455475 |
Pseudarthrosis | 15.11 | 14.19 | 6 | 42249 | 274 | 64456203 |
Face injury | 15.04 | 14.19 | 14 | 42241 | 3091 | 64453386 |
Oestrogen receptor assay positive | 14.99 | 14.19 | 6 | 42249 | 280 | 64456197 |
Septic shock | 14.93 | 14.19 | 29 | 42226 | 105408 | 64351069 |
Psoriasis | 14.86 | 14.19 | 15 | 42240 | 71688 | 64384789 |
International normalised ratio increased | 14.83 | 14.19 | 18 | 42237 | 79149 | 64377328 |
Extrasystoles | 14.82 | 14.19 | 20 | 42235 | 6638 | 64449839 |
Emphysema | 14.63 | 14.19 | 30 | 42225 | 14039 | 64442438 |
Hypoxia | 14.53 | 14.19 | 22 | 42233 | 88127 | 64368350 |
Pain in jaw | 14.49 | 14.19 | 59 | 42196 | 40696 | 64415781 |
Productive cough | 14.41 | 14.19 | 16 | 42239 | 73187 | 64383290 |
Abdominal pain | 14.39 | 14.19 | 133 | 42122 | 312242 | 64144235 |
Accident | 14.39 | 14.19 | 20 | 42235 | 6826 | 64449651 |
Serotonin syndrome | 14.29 | 14.19 | 4 | 42251 | 39278 | 64417199 |
Hepatitis | 14.24 | 14.19 | 6 | 42249 | 45576 | 64410901 |
Cardiac pacemaker insertion | 14.21 | 14.19 | 17 | 42238 | 5006 | 64451471 |
Transient ischaemic attack | 14.19 | 14.19 | 62 | 42193 | 44120 | 64412357 |
None
Source | Code | Description |
---|---|---|
ATC | H05AA02 | SYSTEMIC HORMONAL PREPARATIONS, EXCL. SEX HORMONES AND INSULINS CALCIUM HOMEOSTASIS PARATHYROID HORMONES AND ANALOGUES Parathyroid hormones and analogues |
FDA CS | M0015931 | Parathyroid Hormone |
FDA EPC | N0000180852 | Parathyroid Hormone Analog |
MeSH PA | D050071 | Bone Density Conservation Agents |
MeSH PA | D000077264 | Calcium-Regulating Hormones and Agents |
Disease | Relation | SNOMED_ID | DOID |
---|---|---|---|
Postmenopausal osteoporosis | indication | 102447009 | |
Glucocorticoid Induced Osteoporosis | indication | ||
Hypogonadal Osteoporosis in Males | indication | ||
Osteitis deformans | contraindication | 2089002 | DOID:5408 |
Osteomalacia | contraindication | 4598005 | DOID:10573 |
Renal osteodystrophy | contraindication | 16726004 | DOID:13068 |
Hepatic osteodystrophy | contraindication | 28193003 | |
Rickets | contraindication | 41345002 | DOID:10609 |
Low blood pressure | contraindication | 45007003 | |
Hypercalcemia | contraindication | 66931009 | DOID:12678 |
Osteitis fibrosa cystica generalisata | contraindication | 84727000 | DOID:3341 |
Urolithiasis | contraindication | 95566004 | |
Osteosarcoma of bone | contraindication | 307576001 | DOID:3376 |
Breastfeeding (mother) | contraindication | 413712001 | |
Bone Metastases | contraindication | ||
Malignant Bone Disease | contraindication | ||
Radiation Therapy Involving Bone | contraindication |
None
None
Dissociation level | Dissociation constant | Type (acidic/basic) |
---|---|---|
pKa1 | 3.23 | acidic |
pKa2 | 3.31 | acidic |
pKa3 | 3.82 | acidic |
pKa4 | 4.11 | acidic |
pKa5 | 4.44 | acidic |
pKa6 | 11.68 | acidic |
pKa7 | 12.17 | acidic |
pKa8 | 12.35 | acidic |
pKa9 | 12.6 | acidic |
pKa10 | 12.63 | acidic |
pKa11 | 12.75 | acidic |
pKa12 | 12.78 | acidic |
pKa13 | 12.93 | acidic |
pKa14 | 13.16 | acidic |
pKa15 | 13.18 | acidic |
pKa16 | 13.37 | acidic |
pKa17 | 13.37 | acidic |
pKa18 | 13.44 | acidic |
pKa19 | 13.47 | acidic |
pKa20 | 13.57 | acidic |
pKa21 | 13.72 | acidic |
pKa22 | 13.72 | acidic |
pKa23 | 13.74 | acidic |
pKa24 | 13.82 | acidic |
pKa25 | 13.89 | acidic |
pKa26 | 11.47 | Basic |
pKa27 | 11.08 | Basic |
pKa28 | 10.81 | Basic |
pKa29 | 10.48 | Basic |
pKa30 | 10.09 | Basic |
pKa31 | 7.63 | Basic |
pKa32 | 7.16 | Basic |
pKa33 | 6.69 | Basic |
pKa34 | 6.21 | Basic |
None
None
Target | Class | Pharos | UniProt | Action | Type | Activity value (-log[M]) | Mechanism action | Bioact source | MoA source |
---|---|---|---|---|---|---|---|---|---|
Parathyroid hormone/parathyroid hormone-related peptide receptor | GPCR | AGONIST | IC50 | 7.40 | IUPHAR | CHEMBL | |||
Parathyroid hormone 2 receptor | GPCR | AGONIST | IC50 | 7.80 | IUPHAR | ||||
Parathyroid hormone 2 receptor | GPCR | AGONIST | IC50 | 6.30 | IUPHAR | ||||
Parathyroid hormone/parathyroid hormone-related peptide receptor | GPCR | AGONIST | IC50 | 8.70 | IUPHAR |
ID | Source |
---|---|
D03358 | KEGG_DRUG |
4019512 | VUID |
N0000147632 | NUI |
99294-94-7 | SECONDARY_CAS_RN |
4019512 | VANDF |
CHEBI:135983 | CHEBI |
CHEMBL525610 | ChEMBL_ID |
4448 | IUPHAR_LIGAND_ID |
5411 | INN_ID |
DB06285 | DRUGBANK_ID |
10T9CSU89I | UNII |
155817470 | PUBCHEM_CID |
114260 | RXNORM |
17041 | MMSL |
336918 | MMSL |
d04828 | MMSL |
002142 | NDDF |
004944 | NDDF |
109198008 | SNOMEDCT_US |
398823001 | SNOMEDCT_US |
425438001 | SNOMEDCT_US |
D019379 | MESH_DESCRIPTOR_UI |
C0070093 | UMLSCUI |
CHEMBL1201549 | ChEMBL_ID |
Product | Category | Ingredients | NDC | Form | Quantity | Route | Marketing | Label |
---|---|---|---|---|---|---|---|---|
Forteo | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0002-8400 | INJECTION, SOLUTION | 250 ug | SUBCUTANEOUS | NDA | 35 sections |
teriparatide | HUMAN PRESCRIPTION DRUG LABEL | 1 | 47781-652 | INJECTION, SOLUTION | 250 ug | SUBCUTANEOUS | NDA | 30 sections |