teriparatide 🐶 Veterinary Use | Indications/Contra | FAERs-F | FAERs-M | Orange Bk | BioActivity |

Stem definitionDrug idCAS RN
peptides and glycopeptides 4514 52232-67-4

Description:

MoleculeDescription

Molfile Inchi Smiles

Synonyms:

  • teriparatide recombinant human
  • forsteo
  • teriparatide
  • teriparatide acetate
  • hPTH 1-34
  • parathar
A polypeptide that consists of the 1-34 amino-acid fragment of human PARATHYROID HORMONE, the biologically active N-terminal region. The acetate form is given by intravenous infusion in the differential diagnosis of HYPOPARATHYROIDISM and PSEUDOHYPOPARATHYROIDISM. (Reynolds JEF(Ed): Martindale: The Extra Pharmacopoeia (electronic version). Micromedex, Inc, Englewood, CO, 1995)
  • Molecular weight: 4117.77
  • Formula: C181H291N55O51S2
  • CLOGP:
  • LIPINSKI: None
  • HAC: 106
  • HDO: 60
  • TPSA: 1752.65
  • ALOGS:
  • ROTB: 144

Drug dosage:

DoseUnitRoute
20 mcg P

ADMET properties:

PropertyValueReference
Vd (Volume of distribution) 0.17 L/kg Lombardo F, Berellini G, Obach RS
CL (Clearance) 21.40 mL/min/kg Lombardo F, Berellini G, Obach RS
t_half (Half-life) 0.14 hours Lombardo F, Berellini G, Obach RS

Approvals:

DateAgencyCompanyOrphan
July 23, 2019 PMDA Eli Lilly Japan
June 10, 2003 EMA
Nov. 26, 2002 FDA LILLY

FDA Adverse Event Reporting System (Female)

MedDRA adverse event termLikelihood ratioLikelihood ratio thresholdPatients taking drug having adverse eventPatients taking drug not having adverse eventPatients not taking drug having adverse eventPatients not taking drug not having adverse event
Fall 1261.69 13.20 1834 63585 333098 50206607
Product complaint 1205.75 13.20 480 64939 10986 50528719
Blood calcium increased 945.35 13.20 361 65058 7358 50532347
Hip fracture 740.53 13.20 445 64974 25486 50514219
Bone pain 710.87 13.20 545 64874 46684 50493021
Muscle spasms 529.36 13.20 728 64691 124825 50414880
Therapy cessation 483.31 13.20 341 65078 25670 50514035
Drug ineffective 475.60 13.20 235 65184 819098 49720607
Injection site haemorrhage 468.08 13.20 310 65109 21036 50518669
Hospitalisation 443.13 13.20 491 64928 67446 50472259
Spinal fracture 441.19 13.20 266 65153 15307 50524398
Product storage error 423.66 13.20 238 65181 11986 50527719
Dizziness 423.20 13.20 1188 64231 345181 50194524
Femur fracture 329.44 13.20 318 65101 37146 50502559
Pelvic fracture 319.14 13.20 194 65225 11326 50528379
Hypercalcaemia 311.18 13.20 251 65168 23101 50516604
Pain in extremity 277.52 13.20 878 64541 271987 50267718
Fracture 272.33 13.20 203 65216 16630 50523075
Injection site erythema 271.95 13.20 405 65014 74531 50465174
Wrist fracture 261.91 13.20 171 65248 11316 50528389
Back pain 245.91 13.20 732 64687 219298 50320407
Injection site bruising 239.98 13.20 266 65153 36502 50503203
Toxicity to various agents 219.55 13.20 14 65405 212485 50327220
Bone density decreased 219.19 13.20 151 65268 10924 50528781
Rib fracture 201.47 13.20 180 65239 19041 50520664
Off label use 198.53 13.20 193 65226 474233 50065472
Injection site haematoma 185.90 13.20 109 65310 5951 50533754
Arthralgia 177.71 13.20 1069 64350 437633 50102072
Drug intolerance 177.64 13.20 34 65385 219070 50320635
Upper limb fracture 173.03 13.20 152 65267 15721 50523984
Infusion related reaction 167.00 13.20 14 65405 169543 50370162
Feeling abnormal 164.86 13.20 443 64976 125049 50414656
Spinal operation 164.63 13.20 102 65317 6158 50533547
Injection site pain 164.43 13.20 410 65009 110614 50429091
Completed suicide 151.70 13.20 4 65415 131885 50407820
Treatment failure 148.50 13.20 7 65412 137630 50402075
Neutropenia 143.57 13.20 13 65406 147952 50391753
Asthenia 142.95 13.20 799 64620 318243 50221462
Acute kidney injury 135.01 13.20 63 65356 227995 50311710
Drug hypersensitivity 134.34 13.20 79 65340 250931 50288774
Lumbar vertebral fracture 133.97 13.20 80 65339 4517 50535188
Femoral neck fracture 129.40 13.20 94 65325 7396 50532309
Product dose omission issue 128.60 13.20 524 64895 183314 50356391
Chronic obstructive pulmonary disease 124.48 13.20 237 65182 53198 50486507
Nephrolithiasis 123.58 13.20 186 65233 34507 50505198
Vertebroplasty 121.41 13.20 35 65384 279 50539426
Synovitis 119.84 13.20 11 65408 123854 50415851
Therapeutic product effect decreased 119.35 13.20 17 65402 136033 50403672
Febrile neutropenia 108.56 13.20 4 65415 97663 50442042
Drug interaction 107.94 13.20 62 65357 199559 50340146
Bone disorder 107.65 13.20 127 65292 18625 50521080
Spinal compression fracture 106.62 13.20 105 65314 12551 50527154
Compression fracture 104.82 13.20 75 65344 5762 50533943
Glossodynia 104.80 13.20 13 65406 115556 50424149
Hand deformity 102.22 13.20 7 65412 100192 50439513
Pyrexia 100.99 13.20 213 65206 379990 50159715
Foot fracture 99.03 13.20 126 65293 19965 50519740
Surgery 97.84 13.20 155 65264 30050 50509655
Product use issue 96.93 13.20 36 65383 149439 50390266
Thoracic vertebral fracture 93.72 13.20 61 65358 4012 50535693
Systemic lupus erythematosus 92.65 13.20 33 65386 140589 50399116
Blood alkaline phosphatase increased 91.81 13.20 170 65249 37356 50502349
Therapeutic product effect incomplete 91.61 13.20 7 65412 91508 50448197
Heart rate increased 90.77 13.20 262 65157 76988 50462717
Product use in unapproved indication 89.59 13.20 20 65399 115799 50423906
Gait disturbance 88.27 13.20 406 65013 149599 50390106
Humerus fracture 87.15 13.20 75 65344 7543 50532162
Palpitations 79.64 13.20 286 65133 94220 50445485
Hepatic enzyme increased 79.62 13.20 39 65380 137341 50402364
Thrombocytopenia 79.06 13.20 33 65386 127640 50412065
Osteitis deformans 77.81 13.20 23 65396 202 50539503
Disease progression 77.35 13.20 15 65404 95851 50443854
Myalgia 77.24 13.20 342 65077 123977 50415728
Ankle fracture 73.41 13.20 96 65323 15626 50524079
Therapy interrupted 73.11 13.20 109 65310 20043 50519662
Rheumatoid arthritis 72.79 13.20 93 65326 202457 50337248
Wound 67.69 13.20 26 65393 105768 50433937
Vitamin D decreased 67.59 13.20 68 65351 8338 50531367
Medication error 67.25 13.20 146 65273 35958 50503747
Patella fracture 66.89 13.20 37 65382 1805 50537900
Pericarditis 66.32 13.20 11 65408 78678 50461027
Malignant neoplasm progression 66 13.20 6 65413 68118 50471587
Rash 65.51 13.20 317 65102 437154 50102551
Stomatitis 64.69 13.20 25 65394 101319 50438386
White blood cell count decreased 63.40 13.20 36 65383 116686 50423019
Cerebrovascular accident 63.03 13.20 266 65153 94414 50445291
Tibia fracture 61.49 13.20 49 65370 4426 50535279
Condition aggravated 60.61 13.20 190 65229 296868 50242837
Lower respiratory tract infection 59.91 13.20 24 65395 95177 50444528
Hand fracture 59.43 13.20 48 65371 4420 50535285
Intentional overdose 59.24 13.20 6 65413 62498 50477207
Lower limb fracture 58.91 13.20 82 65337 14164 50525541
Drug abuse 58.71 13.20 5 65414 59841 50479864
Contusion 57.55 13.20 292 65127 111891 50427814
Recalled product 57.40 13.20 30 65389 1305 50538400
Diarrhoea 56.21 13.20 489 64930 587987 49951718
Stress fracture 55.98 13.20 56 65363 6819 50532886
Leukopenia 55.67 13.20 10 65409 67518 50472187
Swelling 53.66 13.20 112 65307 200760 50338945
Nausea 53.52 13.20 1239 64180 704159 49835546
Platelet count decreased 51.99 13.20 33 65386 100693 50439012
Cardiac disorder 49.72 13.20 145 65274 42834 50496871
Blood parathyroid hormone increased 49.71 13.20 36 65383 2818 50536887
Helicobacter infection 49.17 13.20 4 65415 49698 50490007
Myocardial infarction 48.68 13.20 236 65183 88791 50450914
Pancytopenia 48.45 13.20 24 65395 84006 50455699
Duodenal ulcer perforation 47.05 13.20 3 65416 45608 50494097
Intentional product use issue 45.83 13.20 21 65398 76897 50462808
Psoriasis 45.75 13.20 16 65403 68984 50470721
Breast cancer 45.17 13.20 140 65279 42750 50496955
Balance disorder 45.17 13.20 196 65223 70394 50469311
Malaise 45.02 13.20 645 64774 334887 50204818
Head injury 44.57 13.20 97 65322 23923 50515782
Anaphylactic reaction 44.57 13.20 8 65411 54047 50485658
Urine calcium increased 44.14 13.20 11 65408 46 50539659
Pathological fracture 44.04 13.20 52 65367 7630 50532075
Fractured sacrum 44.02 13.20 28 65391 1770 50537935
Nervousness 43.92 13.20 105 65314 27546 50512159
Therapeutic response decreased 43.57 13.20 5 65414 47226 50492479
Musculoskeletal discomfort 43.55 13.20 73 65346 14825 50524880
Calciphylaxis 43.06 13.20 32 65387 2606 50537099
Hypersensitivity 42.87 13.20 139 65280 215022 50324683
Hip surgery 42.85 13.20 32 65387 2626 50537079
Body height decreased 42.53 13.20 55 65364 8853 50530852
Neutrophil count decreased 42.14 13.20 5 65414 46021 50493684
Suicide attempt 41.92 13.20 8 65411 51724 50487981
Peripheral swelling 41.76 13.20 132 65287 205804 50333901
Joint swelling 41.28 13.20 170 65249 245116 50294589
Fear 40.82 13.20 70 65349 14479 50525226
Bone fissure 40.72 13.20 13 65406 151 50539554
Sinusitis 39.97 13.20 102 65317 170456 50369249
Incorrect product administration duration 39.27 13.20 54 65365 9221 50530484
Cervical vertebral fracture 39.11 13.20 28 65391 2152 50537553
Fracture nonunion 38.84 13.20 28 65391 2176 50537529
Arrhythmia 38.53 13.20 112 65307 33020 50506685
Injection site rash 37.95 13.20 72 65347 16105 50523600
Abdominal pain 37.73 13.20 167 65252 236061 50303644
Lung neoplasm malignant 37.67 13.20 70 65349 15414 50524291
Transient ischaemic attack 37.57 13.20 109 65310 32101 50507604
Breast cancer in situ 36.82 13.20 23 65396 1408 50538297
Folliculitis 36.57 13.20 4 65415 39221 50500484
Bradycardia 36.24 13.20 19 65400 64407 50475298
Neuropathy peripheral 36.22 13.20 43 65376 96714 50442991
Dyspnoea 36.17 13.20 495 64924 547113 49992592
Road traffic accident 36.05 13.20 90 65329 24262 50515443
Alanine aminotransferase increased 35.56 13.20 37 65382 88322 50451383
Death 35.43 13.20 604 64815 324775 50214930
Ulna fracture 35.41 13.20 20 65399 1016 50538689
Wheezing 35.34 13.20 18 65401 62029 50477676
Hypokalaemia 35.24 13.20 37 65382 87955 50451750
Hypotension 34.92 13.20 171 65248 235298 50304407
Hip arthroplasty 34.55 13.20 102 65317 30327 50509378
Post procedural complication 33.93 13.20 66 65353 15038 50524667
Osteocalcin increased 33.91 13.20 6 65413 0 50539705
N-telopeptide urine increased 33.91 13.20 6 65413 0 50539705
Calcinosis 33.37 13.20 24 65395 1858 50537847
Fibula fracture 33.13 13.20 29 65390 2983 50536722
Weight decreased 32.75 13.20 433 64986 220812 50318893
Device failure 32.65 13.20 38 65381 5490 50534215
Movement disorder 32.48 13.20 71 65348 17561 50522144
Injury associated with device 32.27 13.20 29 65390 3088 50536617
Abdominal discomfort 32.21 13.20 172 65247 231469 50308236
Blood calcium abnormal 31.91 13.20 19 65400 1067 50538638
Radius fracture 31.55 13.20 29 65390 3180 50536525
Pain 31.16 13.20 973 64446 577930 49961775
Muscular weakness 31.13 13.20 220 65199 94793 50444912
Blister 30.87 13.20 39 65380 85379 50454326
Multiple fractures 30.29 13.20 40 65379 6571 50533134
Loss of consciousness 29.86 13.20 234 65185 104119 50435586
Accident 29.80 13.20 35 65384 5106 50534599
Memory impairment 29.74 13.20 190 65229 79170 50460535
Muscle injury 29.52 13.20 6 65413 37105 50502600
Atypical femur fracture 29.38 13.20 34 65385 4882 50534823
Back disorder 29.09 13.20 47 65372 9258 50530447
Neck pain 28.86 13.20 148 65271 56919 50482786
Hypercalciuria 28.83 13.20 11 65408 223 50539482
Suicidal ideation 28.77 13.20 18 65401 55367 50484338
Multiple sclerosis relapse 28.41 13.20 10 65409 42954 50496751
Haemoglobin decreased 28.33 13.20 78 65341 127138 50412567
Hyperparathyroidism 28.08 13.20 24 65395 2390 50537315
Clavicle fracture 27.81 13.20 26 65393 2913 50536792
Emphysema 27.17 13.20 45 65374 9048 50530657
Osteonecrosis 27.03 13.20 77 65342 22440 50517265
Agitation 26.84 13.20 18 65401 53366 50486339
Spinal deformity 26.24 13.20 16 65403 938 50538767
Accidental underdose 26.06 13.20 14 65405 644 50539061
Breast calcifications 25.85 13.20 17 65402 1138 50538567
Metabolic acidosis 25.74 13.20 9 65410 38816 50500889
C-reactive protein increased 25.46 13.20 29 65390 66445 50473260
Bone marrow failure 25.29 13.20 3 65416 27621 50512084
Dementia Alzheimer's type 25.06 13.20 16 65403 1018 50538687
Headache 24.79 13.20 842 64577 505693 50034012
Calcium ionised increased 24.67 13.20 8 65411 98 50539607
Vomiting 24.44 13.20 434 64985 460324 50079381
Bone scan abnormal 24.32 13.20 11 65408 347 50539358
Facial bones fracture 24.27 13.20 25 65394 3152 50536553
Joint dislocation 24.26 13.20 51 65368 12282 50527423
Oxygen saturation decreased 23.90 13.20 36 65383 73212 50466493
Blood bilirubin increased 23.84 13.20 6 65413 32032 50507673
Discomfort 23.72 13.20 67 65352 108313 50431392
Enchondromatosis 23.53 13.20 7 65412 63 50539642
Hernial eventration 23.49 13.20 5 65414 8 50539697
Sternal fracture 23.49 13.20 20 65399 1982 50537723
Colon cancer 23.32 13.20 41 65378 8650 50531055
Hypoacusis 23.24 13.20 69 65350 20578 50519127
Bone cancer 23.05 13.20 16 65403 1171 50538534
Heart rate irregular 23.04 13.20 66 65353 19294 50520411
Liver function test increased 22.91 13.20 3 65416 25603 50514102
Angioedema 22.89 13.20 10 65409 37666 50502039
Vein disorder 22.74 13.20 28 65391 4291 50535414
Rhabdomyolysis 22.71 13.20 11 65408 39016 50500689
Osteoporotic fracture 22.68 13.20 24 65395 3121 50536584
Cementoplasty 22.61 13.20 4 65415 0 50539705
Ilium fracture 22.55 13.20 8 65411 131 50539574
Addison's disease 22.44 13.20 7 65412 75 50539630
Nerve compression 22.39 13.20 37 65382 7425 50532280
Aspartate aminotransferase increased 22.08 13.20 42 65377 77956 50461749
Encephalopathy 22.03 13.20 8 65411 33703 50506002
Breast cancer female 21.92 13.20 35 65384 6827 50532878
Hallucination, synaesthetic 21.74 13.20 6 65413 40 50539665
Dysstasia 21.45 13.20 61 65358 17758 50521947
Visual acuity reduced 21.44 13.20 66 65353 20073 50519632
Groin pain 21.38 13.20 40 65379 8851 50530854
Sleep disorder due to general medical condition, insomnia type 21.35 13.20 7 65412 31440 50508265
Cardio-respiratory arrest 21.20 13.20 23 65396 53869 50485836
Type 2 diabetes mellitus 21.08 13.20 9 65410 34366 50505339
Alopecia 20.95 13.20 209 65210 244838 50294867
General physical health deterioration 20.77 13.20 104 65315 142330 50397375
Limb discomfort 20.73 13.20 74 65345 24283 50515422
Hernia hiatus repair 20.68 13.20 6 65413 49 50539656
Hyperkalaemia 20.66 13.20 19 65400 48070 50491635
Leukaemia 20.58 13.20 24 65395 3475 50536230
Drug eruption 20.56 13.20 3 65416 23603 50516102
Hypervolaemia 20.53 13.20 4 65415 25495 50514210
Extraskeletal ossification 20.17 13.20 7 65412 107 50539598
Hepatic cancer 20.16 13.20 23 65396 3252 50536453
Drug withdrawal syndrome 20.06 13.20 4 65415 25077 50514628
Plasma cell myeloma 20.05 13.20 87 65332 31235 50508470
Vertigo 19.97 13.20 125 65294 51707 50487998
Prosthesis implantation 19.79 13.20 6 65413 58 50539647
Serotonin syndrome 19.64 13.20 4 65415 24709 50514996
Influenza 19.46 13.20 189 65230 89349 50450356
Complication associated with device 19.46 13.20 52 65367 14603 50525102
Injection site irritation 19.44 13.20 26 65393 4324 50535381
Transaminases increased 19.23 13.20 6 65413 27818 50511887
Hyponatraemia 19.20 13.20 62 65357 96077 50443628
Constipation 19.18 13.20 342 65077 185366 50354339
Gammopathy 19.17 13.20 7 65412 125 50539580
Productive cough 19.10 13.20 24 65395 52670 50487035
Irritable bowel syndrome 19.10 13.20 23 65396 51418 50488287
Arthropathy 18.87 13.20 123 65296 157783 50381922
Pleural effusion 18.84 13.20 49 65370 81405 50458300
Oedema 18.82 13.20 39 65380 70142 50469563
Tetany 18.62 13.20 16 65403 1605 50538100
Cough 18.51 13.20 211 65208 241053 50298652
Neoplasm malignant 18.46 13.20 70 65349 23645 50516060
Parkinson's disease 18.40 13.20 14 65405 1181 50538524
Musculoskeletal chest pain 18.23 13.20 59 65360 18427 50521278
Intestinal obstruction 18.22 13.20 75 65344 26308 50513397
Hepatitis 18.10 13.20 9 65410 31444 50508261
Injection site streaking 18.04 13.20 5 65414 34 50539671
Rash maculo-papular 17.96 13.20 6 65413 26635 50513070
Drug ineffective for unapproved indication 17.87 13.20 3 65416 21278 50518427
Liver injury 17.78 13.20 5 65414 24801 50514904
Sleep disorder due to a general medical condition 17.53 13.20 33 65386 7338 50532367
Cystitis 17.50 13.20 108 65311 44456 50495249
Fracture malunion 17.33 13.20 7 65412 166 50539539
Sedation 17.25 13.20 9 65410 30601 50509104
Rehabilitation therapy 17.24 13.20 14 65405 1299 50538406
Hepatocellular injury 17.22 13.20 6 65413 25941 50513764
Spinal disorder 17.20 13.20 35 65384 8235 50531470
Product distribution issue 17.18 13.20 11 65408 703 50539002
Infection 17.17 13.20 142 65277 172812 50366893
Growing pains 17.08 13.20 4 65415 12 50539693
Posture abnormal 16.98 13.20 17 65402 2072 50537633
Basosquamous carcinoma of skin 16.96 13.20 3 65416 0 50539705
Wrong product stored 16.96 13.20 3 65416 0 50539705
Pulmonary arterial hypertension 16.76 13.20 3 65416 20316 50519389
Joint arthroplasty 16.75 13.20 17 65402 2106 50537599
Blood creatinine increased 16.72 13.20 47 65372 76113 50463592
Joint injury 16.70 13.20 64 65355 21725 50517980
Upper respiratory tract infection 16.53 13.20 38 65381 65860 50473845
Face injury 16.31 13.20 19 65400 2747 50536958
Injection site discolouration 16.31 13.20 31 65388 6943 50532762
Liver function test abnormal 16.27 13.20 20 65399 44319 50495386
Dystrophic calcification 16.19 13.20 6 65413 112 50539593
Cataract operation 16.01 13.20 23 65396 4088 50535617
Gait inability 15.99 13.20 92 65327 36935 50502770
Parathyroid tumour benign 15.98 13.20 10 65409 614 50539091
Spinal stenosis 15.94 13.20 46 65373 13504 50526201
Coma 15.77 13.20 31 65388 56848 50482857
Urinary bladder polyp 15.51 13.20 5 65414 60 50539645
Jaw disorder 15.50 13.20 25 65394 4918 50534787
International normalised ratio increased 15.28 13.20 20 65399 43132 50496573
Extrasystoles 15.22 13.20 24 65395 4631 50535074
Septic shock 15.14 13.20 32 65387 57143 50482562
Scoliosis 15.09 13.20 29 65390 6547 50533158
Spinal fusion surgery 15.05 13.20 22 65397 3973 50535732
Cardiac failure congestive 14.99 13.20 171 65248 84211 50455494
Skeletal injury 14.88 13.20 12 65407 1102 50538603
Traumatic shock 14.88 13.20 3 65416 3 50539702
Acetabulum fracture 14.85 13.20 7 65412 243 50539462
Loss of personal independence in daily activities 14.81 13.20 44 65375 70006 50469699
Cardiac flutter 14.75 13.20 20 65399 3370 50536335
Depressed level of consciousness 14.68 13.20 28 65391 51925 50487780
Neoplasm 14.67 13.20 27 65392 5901 50533804
Psychotic disorder 14.55 13.20 5 65414 21807 50517898
Wrong technique in device usage process 14.53 13.20 17 65402 2469 50537236
Lymphocyte count decreased 14.44 13.20 8 65411 26299 50513406
Knee operation 14.40 13.20 24 65395 4849 50534856
Pain in jaw 14.39 13.20 92 65327 38336 50501369
Multiple organ dysfunction syndrome 14.33 13.20 27 65392 50310 50489395
Pseudarthrosis 14.19 13.20 8 65411 405 50539300
Dyspnoea exertional 14.14 13.20 28 65391 51205 50488500
Cytomegalovirus infection 14.08 13.20 3 65416 17959 50521746
Mass 14.04 13.20 41 65378 12116 50527589
Manufacturing product shipping issue 14.03 13.20 5 65414 83 50539622
Kyphosis 13.93 13.20 16 65403 2279 50537426
Blood lactate dehydrogenase increased 13.92 13.20 4 65415 19558 50520147
Pulmonary embolism 13.85 13.20 76 65343 101628 50438077
Hyperglycaemia 13.81 13.20 16 65403 36389 50503316
Limb crushing injury 13.80 13.20 6 65413 172 50539533
N-telopeptide urine decreased 13.67 13.20 3 65416 6 50539699
Oestrogen receptor assay positive 13.67 13.20 8 65411 435 50539270
Cardiac pacemaker insertion 13.59 13.20 20 65399 3633 50536072
Arterial disorder 13.57 13.20 11 65408 1018 50538687
Intentional product misuse 13.47 13.20 105 65314 46629 50493076
Tremor 13.45 13.20 216 65203 114687 50425018
Bone graft 13.37 13.20 10 65409 822 50538883
Ascites 13.35 13.20 16 65403 35845 50503860
Angina pectoris 13.29 13.20 68 65351 26120 50513585

FDA Adverse Event Reporting System (Male)

MedDRA adverse event termLikelihood ratioLikelihood ratio thresholdPatients taking drug having adverse eventPatients taking drug not having adverse eventPatients not taking drug having adverse eventPatients not taking drug not having adverse event
Hip fracture 124.07 21.92 54 5820 10438 29558215
Hospitalisation 118.74 21.92 87 5787 45901 29522752
Product complaint 113.22 21.92 42 5832 5363 29563290
Bone pain 89.79 21.92 52 5822 18400 29550253
Fall 88.06 21.92 139 5735 177039 29391614
Spinal fracture 75.40 21.92 33 5841 6453 29562200
Therapy cessation 68.34 21.92 40 5834 14422 29554231
Spinal operation 62.69 21.92 22 5852 2392 29566261
Bone density decreased 54.14 21.92 18 5856 1662 29566991
Muscle spasms 45.22 21.92 60 5814 65022 29503631
Back pain 43.53 21.92 75 5799 102209 29466444
Arthralgia 42.84 21.92 89 5785 139528 29429125
Vertebroplasty 41.83 21.92 7 5867 26 29568627
Femur fracture 40.21 21.92 22 5852 6969 29561684
Death 39.77 21.92 153 5721 341931 29226722
Pain in extremity 38.15 21.92 74 5800 110359 29458294
Thoracic vertebral fracture 37.29 21.92 13 5861 1385 29567268
Blood calcium increased 36.18 21.92 16 5858 3203 29565450
Injection site pain 35.96 21.92 38 5836 32408 29536245
Injection site erythema 32.80 21.92 25 5849 13931 29554722
Dizziness 31.76 21.92 96 5778 189588 29379065
Acute kidney injury 31.74 21.92 7 5867 265260 29303393
Injection site haemorrhage 31.41 21.92 20 5854 8366 29560287
Fracture 29.26 21.92 17 5857 6036 29562617
Pneumonia 28.40 21.92 132 5742 320040 29248613
Pain 27.96 21.92 86 5788 171346 29397307
Chronic obstructive pulmonary disease 27.25 21.92 37 5837 40918 29527735
Atypical femur fracture 26.64 21.92 7 5867 284 29568369
Injection site bruising 25.74 21.92 17 5857 7563 29561090
Osteoporotic fracture 25.61 21.92 9 5865 982 29567671
Incorrect product administration duration 24.02 21.92 13 5861 4028 29564625
Upper limb fracture 23.99 21.92 13 5861 4038 29564615
Product storage error 23.16 21.92 15 5859 6455 29562198

FDA Adverse Event Reporting System (Geriatric)

MedDRA adverse event termLikelihood ratioLikelihood ratio thresholdPatients taking drug having adverse eventPatients taking drug not having adverse eventPatients not taking drug having adverse eventPatients not taking drug not having adverse event
Product complaint 1530.79 14.19 486 41769 11468 64445009
Fall 743.81 14.19 1121 41134 415705 64040772
Blood calcium increased 608.63 14.19 224 42031 8318 64448159
Bone pain 492.82 14.19 335 41920 47237 64409240
Product storage error 419.96 14.19 195 42060 13123 64443354
Injection site haemorrhage 411.62 14.19 234 42021 24044 64432433
Hip fracture 403.32 14.19 240 42015 26859 64429618
Muscle spasms 390.29 14.19 471 41784 140552 64315925
Spinal fracture 389.78 14.19 193 42062 14981 64441496
Therapy cessation 310.92 14.19 218 42037 32271 64424206
Dizziness 293.73 14.19 775 41480 429388 64027089
Injection site erythema 290.48 14.19 291 41964 70509 64385968
Injection site bruising 249.68 14.19 200 42055 36173 64420304
Hypercalcaemia 229.05 14.19 179 42076 31237 64425240
Femur fracture 226.46 14.19 184 42071 33951 64422526
Pain in extremity 221.80 14.19 561 41694 302524 64153953
Back pain 219.57 14.19 497 41758 249674 64206803
Wrist fracture 201.33 14.19 108 42147 9893 64446584
Drug ineffective 197.10 14.19 158 42097 840089 63616388
Toxicity to various agents 193.94 14.19 11 42244 363502 64092975
Pelvic fracture 184.87 14.19 104 42151 10459 64446018
Arthralgia 180.59 14.19 667 41588 441593 64014884
Injection site pain 178.12 14.19 286 41969 111122 64345355
Bone density decreased 174.21 14.19 98 42157 9854 64446623
Hospitalisation 172.49 14.19 229 42026 74978 64381499
Acute kidney injury 167.44 14.19 44 42211 449196 64007281
Feeling abnormal 166.36 14.19 307 41948 133295 64323182
Spinal operation 157.43 14.19 78 42177 6055 64450422
Upper limb fracture 140.41 14.19 99 42156 14767 64441710
Fracture 132.66 14.19 105 42150 18650 64437827
Neutropenia 131.67 14.19 6 42249 239618 64216859
Completed suicide 128.85 14.19 4 42251 224410 64232067
Vertebroplasty 125.78 14.19 30 42225 226 64456251
Rib fracture 125.55 14.19 113 42142 23925 64432552
Femoral neck fracture 121.28 14.19 74 42181 8650 64447827
Product dose omission issue 117.46 14.19 336 41919 194411 64262066
Therapy interrupted 110.22 14.19 97 42158 19939 64436538
Lumbar vertebral fracture 104.01 14.19 57 42198 5445 64451032
Off label use 99.23 14.19 164 42091 632642 63823835
Drug interaction 95.11 14.19 60 42195 362023 64094454
Thoracic vertebral fracture 93.97 14.19 50 42205 4503 64451974
Spinal compression fracture 84.22 14.19 73 42182 14702 64441775
Foot fracture 82.52 14.19 79 42176 18078 64438399
Asthenia 80.98 14.19 518 41737 427526 64028951
Nephrolithiasis 80.73 14.19 120 42135 43563 64412914
Pyrexia 77.48 14.19 156 42099 558488 63897989
Pain 73.27 14.19 615 41640 552896 63903581
Product use in unapproved indication 72.26 14.19 14 42241 176604 64279873
Thrombocytopenia 69.18 14.19 30 42225 223771 64232706
Palpitations 67.54 14.19 185 42070 104303 64352174
Humerus fracture 66.43 14.19 49 42206 7836 64448641
Nausea 65.78 14.19 794 41461 785006 63671471
Infusion related reaction 65.28 14.19 14 42241 164453 64292024
Drug abuse 64.77 14.19 6 42249 132368 64324109
Drug intolerance 63.39 14.19 22 42233 187970 64268507
Blood alkaline phosphatase increased 60.94 14.19 122 42133 56157 64400320
Contusion 60.43 14.19 188 42067 113777 64342700
Heart rate increased 60.12 14.19 171 42084 98504 64357973
Disease progression 58.44 14.19 11 42244 141669 64314808
Atypical femur fracture 58.10 14.19 37 42218 4661 64451816
Treatment failure 57.95 14.19 5 42250 116811 64339666
Osteitis deformans 57.08 14.19 15 42240 174 64456303
Hand fracture 56.85 14.19 37 42218 4837 64451640
Compression fracture 55.92 14.19 39 42216 5713 64450764
Chronic obstructive pulmonary disease 53.27 14.19 133 42122 70915 64385562
Malignant neoplasm progression 52.93 14.19 6 42249 112865 64343612
Body height decreased 52.78 14.19 42 42213 7512 64448965
Gait disturbance 52.71 14.19 238 42017 171917 64284560
Pathological fracture 52.35 14.19 45 42210 8960 64447517
Calciphylaxis 50.98 14.19 30 42225 3282 64453195
Therapeutic product effect incomplete 49.81 14.19 5 42250 103477 64353000
Bone disorder 49.54 14.19 58 42197 16701 64439776
Surgery 48.57 14.19 75 42180 28138 64428339
Synovitis 47.14 14.19 5 42250 99085 64357392
Lower limb fracture 47.08 14.19 51 42204 13494 64442983
Urine calcium increased 45.87 14.19 11 42244 85 64456392
Tibia fracture 45.73 14.19 32 42223 4713 64451764
Hypotension 45.69 14.19 115 42140 380859 64075618
Headache 45.44 14.19 538 41717 528929 63927548
Patella fracture 43.28 14.19 21 42234 1557 64454920
Stress fracture 43.04 14.19 33 42222 5591 64450886
Diarrhoea 42.71 14.19 288 41967 722416 63734061
Nervousness 41.95 14.19 72 42183 29484 64426993
Breast cancer 41.37 14.19 71 42184 29077 64427400
Neck pain 40.79 14.19 110 42145 61423 64395054
Pancytopenia 40.02 14.19 22 42233 143287 64313190
Therapeutic product effect decreased 39.74 14.19 13 42242 115338 64341139
Leukopenia 39.39 14.19 9 42246 101233 64355244
Intentional overdose 39.25 14.19 6 42249 89938 64366539
Myalgia 39.01 14.19 206 42049 158411 64298066
Platelet count decreased 38.47 14.19 32 42223 167679 64288798
Musculoskeletal discomfort 37.94 14.19 50 42205 16227 64440250
Bradycardia 37.87 14.19 15 42240 118204 64338273
Injection site rash 37.69 14.19 49 42206 15693 64440784
Blood parathyroid hormone increased 37.07 14.19 24 42231 3110 64453367
Stomatitis 36.63 14.19 13 42242 109592 64346885
White blood cell count decreased 36.34 14.19 30 42225 157807 64298670
Post procedural complication 35.69 14.19 56 42199 21297 64435180
Cerebrovascular accident 35.42 14.19 181 42074 137402 64319075
Drug hypersensitivity 34.96 14.19 64 42191 237751 64218726
Radius fracture 34.30 14.19 23 42232 3161 64453316
Neutrophil count decreased 34.03 14.19 5 42250 77191 64379286
Ankle fracture 34.00 14.19 45 42210 14665 64441812
Fracture nonunion 32.82 14.19 17 42238 1449 64455028
Medication error 32.79 14.19 89 42166 49877 64406600
Blood calcium abnormal 32.33 14.19 16 42239 1238 64455239
Injury associated with device 31.67 14.19 21 42234 2832 64453645
Breast cancer in situ 31.36 14.19 14 42241 858 64455619
Multiple fractures 30.75 14.19 28 42227 6012 64450465
Suicide attempt 30.39 14.19 5 42250 71002 64385475
Bone scan abnormal 30.18 14.19 9 42246 170 64456307
Product use issue 30.06 14.19 33 42222 151682 64304795
Fractured sacrum 29.88 14.19 16 42239 1459 64455018
Cervical vertebral fracture 29.88 14.19 21 42234 3114 64453363
Ulna fracture 29.58 14.19 14 42241 982 64455495
Anaphylactic reaction 29.02 14.19 5 42250 68659 64387818
Hyperkalaemia 29.00 14.19 15 42240 101114 64355363
Rhabdomyolysis 28.79 14.19 12 42243 91714 64364763
Lower respiratory tract infection 28.71 14.19 13 42242 94601 64361876
Balance disorder 28.69 14.19 120 42135 83806 64372671
Agitation 28.65 14.19 11 42244 88356 64368121
Hepatic enzyme increased 28.33 14.19 26 42229 129917 64326560
Hand deformity 27.82 14.19 4 42251 62767 64393710
Osteocalcin increased 27.72 14.19 5 42250 6 64456471
Recalled product 27.54 14.19 13 42242 906 64455571
Osteoporotic fracture 27.29 14.19 21 42234 3577 64452900
Complication associated with device 27.24 14.19 41 42214 15039 64441438
Breast cancer female 26.66 14.19 24 42231 5079 64451398
Memory impairment 26.60 14.19 119 42136 85563 64370914
Metabolic acidosis 26.25 14.19 7 42248 70951 64385526
Cardio-respiratory arrest 26.19 14.19 16 42239 98377 64358100
Calcium ionised increased 26.12 14.19 8 42247 166 64456311
Incorrect product administration duration 25.94 14.19 32 42223 9726 64446751
Hypercalciuria 25.91 14.19 10 42245 423 64456054
Product distribution issue 25.57 14.19 12 42243 826 64455651
Calcinosis 25.44 14.19 16 42239 1972 64454505
Vitamin D decreased 25.08 14.19 28 42227 7659 64448818
Neuropathy peripheral 25.05 14.19 24 42231 117501 64338976
Multiple organ dysfunction syndrome 24.96 14.19 18 42237 101395 64355082
Anaemia 24.81 14.19 146 42109 378534 64077943
Injection site irritation 24.77 14.19 19 42236 3221 64453256
Hallucination, synaesthetic 24.62 14.19 6 42249 50 64456427
Device failure 24.42 14.19 24 42231 5668 64450809
Dystrophic calcification 24.06 14.19 7 42248 121 64456356
Road traffic accident 23.50 14.19 58 42197 30687 64425790
Pericarditis 23.45 14.19 6 42249 62510 64393967
Encephalopathy 23.34 14.19 5 42250 58814 64397663
Cementoplasty 23.09 14.19 4 42251 3 64456474
Vertigo 23.07 14.19 88 42167 58923 64397554
Hip arthroplasty 22.76 14.19 46 42209 21305 64435172
Dyspnoea 22.72 14.19 333 41922 718341 63738136
Bone fissure 22.69 14.19 7 42248 149 64456328
Alanine aminotransferase increased 22.65 14.19 35 42220 138996 64317481
Fear 22.15 14.19 44 42211 20127 64436350
Weight decreased 22.11 14.19 285 41970 285454 64171023
Intentional product use issue 22.10 14.19 18 42237 95346 64361131
Wheezing 21.59 14.19 13 42242 80566 64375911
Osteonecrosis 21.31 14.19 53 42202 28176 64428301
Sternal fracture 21.30 14.19 15 42240 2232 64454245
Dementia Alzheimer's type 20.77 14.19 11 42244 981 64455496
Injection site discolouration 20.66 14.19 24 42231 6851 64449626
Depressed level of consciousness 20.64 14.19 14 42241 81422 64375055
Gammopathy 20.45 14.19 7 42248 209 64456268
Enchondromatosis 20.38 14.19 5 42250 43 64456434
Hip surgery 20.01 14.19 15 42240 2458 64454019
Urinary bladder polyp 19.93 14.19 7 42248 226 64456251
Hypokalaemia 19.56 14.19 31 42224 121872 64334605
Colon cancer 19.36 14.19 32 42223 12707 64443770
Lung neoplasm malignant 19.16 14.19 43 42212 21405 64435072
Fibula fracture 19.11 14.19 16 42239 3072 64453405
Head injury 19.10 14.19 56 42199 32786 64423691
Prosthesis implantation 19.03 14.19 5 42250 58 64456419
Sepsis 18.95 14.19 82 42173 230259 64226218
Growing pains 18.52 14.19 4 42251 18 64456459
C-reactive protein increased 18.40 14.19 21 42234 94888 64361589
Arrhythmia 18.32 14.19 76 42179 52868 64403609
Parkinson's disease 18.30 14.19 12 42243 1589 64454888
Injection site urticaria 18.24 14.19 29 42226 11152 64445325
Hyperparathyroidism 18.12 14.19 15 42240 2837 64453640
Cardiac arrest 18.04 14.19 47 42208 154017 64302460
Extraskeletal ossification 18.03 14.19 5 42250 72 64456405
Musculoskeletal chest pain 18.01 14.19 42 42213 21437 64435040
Wrong technique in device usage process 17.98 14.19 15 42240 2867 64453610
Angioedema 17.98 14.19 9 42246 61812 64394665
Glossodynia 17.96 14.19 10 42245 64686 64391791
Fatigue 17.91 14.19 628 41627 748102 63708375
Groin pain 17.83 14.19 29 42226 11364 64445113
Joint dislocation 17.69 14.19 29 42226 11436 64445041
Oxygen saturation decreased 17.43 14.19 27 42228 107149 64349328
Leukaemia 17.41 14.19 19 42236 5069 64451408
Blood bilirubin increased 17.31 14.19 8 42247 57545 64398932
General physical health deterioration 17.29 14.19 72 42183 204353 64252124
Tetany 17.18 14.19 13 42242 2159 64454318
Vein disorder 17.10 14.19 17 42238 4070 64452407
Breast calcifications 17.01 14.19 9 42246 801 64455676
Cardiac disorder 16.93 14.19 77 42178 55739 64400738
Unresponsive to stimuli 16.79 14.19 6 42249 50387 64406090
Pneumonitis 16.78 14.19 6 42249 50359 64406118
Manufacturing product shipping issue 16.74 14.19 5 42250 95 64456382
Rash maculo-papular 16.72 14.19 5 42250 47021 64409456
Gastrointestinal haemorrhage 16.56 14.19 39 42216 132273 64324204
Clavicle fracture 16.44 14.19 16 42239 3733 64452744
Back disorder 16.42 14.19 26 42229 9964 64446513
Bone cancer 16.32 14.19 11 42244 1524 64454953
Neoplasm malignant 16.22 14.19 44 42211 24644 64431833
Suicidal ideation 16.13 14.19 12 42243 66530 64389947
Delirium 16.11 14.19 13 42242 69181 64387296
Hyperglycaemia 16.10 14.19 10 42245 60958 64395519
Muscle disorder 16.09 14.19 18 42237 4933 64451544
Pleural effusion 16.08 14.19 37 42218 126522 64329955
Hyponatraemia 16.07 14.19 47 42208 148292 64308185
Aspartate aminotransferase increased 16.06 14.19 34 42221 119754 64336723
Atypical fracture 15.82 14.19 8 42247 648 64455829
Helicobacter infection 15.76 14.19 3 42252 38359 64418118
Laryngeal pain 15.73 14.19 19 42236 5649 64450828
Wrong product stored 15.70 14.19 3 42252 6 64456471
Haemoglobin decreased 15.70 14.19 70 42185 194993 64261484
Agranulocytosis 15.69 14.19 3 42252 38226 64418251
N-telopeptide urine increased 15.50 14.19 4 42251 43 64456434
Limb discomfort 15.48 14.19 46 42209 27129 64429348
Blood creatinine increased 15.46 14.19 42 42213 135740 64320737
Hypoglycaemia 15.25 14.19 22 42233 89870 64366607
Breast enlargement 15.19 14.19 10 42245 1332 64455145
Intervertebral disc compression 15.15 14.19 9 42246 1002 64455475
Pseudarthrosis 15.11 14.19 6 42249 274 64456203
Face injury 15.04 14.19 14 42241 3091 64453386
Oestrogen receptor assay positive 14.99 14.19 6 42249 280 64456197
Septic shock 14.93 14.19 29 42226 105408 64351069
Psoriasis 14.86 14.19 15 42240 71688 64384789
International normalised ratio increased 14.83 14.19 18 42237 79149 64377328
Extrasystoles 14.82 14.19 20 42235 6638 64449839
Emphysema 14.63 14.19 30 42225 14039 64442438
Hypoxia 14.53 14.19 22 42233 88127 64368350
Pain in jaw 14.49 14.19 59 42196 40696 64415781
Productive cough 14.41 14.19 16 42239 73187 64383290
Abdominal pain 14.39 14.19 133 42122 312242 64144235
Accident 14.39 14.19 20 42235 6826 64449651
Serotonin syndrome 14.29 14.19 4 42251 39278 64417199
Hepatitis 14.24 14.19 6 42249 45576 64410901
Cardiac pacemaker insertion 14.21 14.19 17 42238 5006 64451471
Transient ischaemic attack 14.19 14.19 62 42193 44120 64412357

FDA Adverse Event Reporting System (Pediatric)

None

Pharmacologic Action:

SourceCodeDescription
ATC H05AA02 SYSTEMIC HORMONAL PREPARATIONS, EXCL. SEX HORMONES AND INSULINS
CALCIUM HOMEOSTASIS
PARATHYROID HORMONES AND ANALOGUES
Parathyroid hormones and analogues
FDA CS M0015931 Parathyroid Hormone
FDA EPC N0000180852 Parathyroid Hormone Analog
MeSH PA D050071 Bone Density Conservation Agents
MeSH PA D000077264 Calcium-Regulating Hormones and Agents

Drug Use | Suggest Off label Use Form| |View source of the data|

DiseaseRelationSNOMED_IDDOID
Postmenopausal osteoporosis indication 102447009
Glucocorticoid Induced Osteoporosis indication
Hypogonadal Osteoporosis in Males indication
Osteitis deformans contraindication 2089002 DOID:5408
Osteomalacia contraindication 4598005 DOID:10573
Renal osteodystrophy contraindication 16726004 DOID:13068
Hepatic osteodystrophy contraindication 28193003
Rickets contraindication 41345002 DOID:10609
Low blood pressure contraindication 45007003
Hypercalcemia contraindication 66931009 DOID:12678
Osteitis fibrosa cystica generalisata contraindication 84727000 DOID:3341
Urolithiasis contraindication 95566004
Osteosarcoma of bone contraindication 307576001 DOID:3376
Breastfeeding (mother) contraindication 413712001
Bone Metastases contraindication
Malignant Bone Disease contraindication
Radiation Therapy Involving Bone contraindication




🐶 Veterinary Drug Use

None

🐶 Veterinary products

None

Acid dissociation constants calculated using MoKa v3.0.0

Dissociation levelDissociation constantType (acidic/basic)
pKa1 3.23 acidic
pKa2 3.31 acidic
pKa3 3.82 acidic
pKa4 4.11 acidic
pKa5 4.44 acidic
pKa6 11.68 acidic
pKa7 12.17 acidic
pKa8 12.35 acidic
pKa9 12.6 acidic
pKa10 12.63 acidic
pKa11 12.75 acidic
pKa12 12.78 acidic
pKa13 12.93 acidic
pKa14 13.16 acidic
pKa15 13.18 acidic
pKa16 13.37 acidic
pKa17 13.37 acidic
pKa18 13.44 acidic
pKa19 13.47 acidic
pKa20 13.57 acidic
pKa21 13.72 acidic
pKa22 13.72 acidic
pKa23 13.74 acidic
pKa24 13.82 acidic
pKa25 13.89 acidic
pKa26 11.47 Basic
pKa27 11.08 Basic
pKa28 10.81 Basic
pKa29 10.48 Basic
pKa30 10.09 Basic
pKa31 7.63 Basic
pKa32 7.16 Basic
pKa33 6.69 Basic
pKa34 6.21 Basic

Orange Book patent data (new drug applications)

None

Orange Book exclusivity data (new drug applications)

None

Bioactivity Summary:

TargetClassPharosUniProtActionTypeActivity value
(-log[M])
Mechanism
action
Bioact sourceMoA source
Parathyroid hormone/parathyroid hormone-related peptide receptor GPCR AGONIST IC50 7.40 IUPHAR CHEMBL
Parathyroid hormone 2 receptor GPCR AGONIST IC50 7.80 IUPHAR
Parathyroid hormone 2 receptor GPCR AGONIST IC50 6.30 IUPHAR
Parathyroid hormone/parathyroid hormone-related peptide receptor GPCR AGONIST IC50 8.70 IUPHAR

External reference:

IDSource
D03358 KEGG_DRUG
4019512 VUID
N0000147632 NUI
99294-94-7 SECONDARY_CAS_RN
4019512 VANDF
CHEBI:135983 CHEBI
CHEMBL525610 ChEMBL_ID
4448 IUPHAR_LIGAND_ID
5411 INN_ID
DB06285 DRUGBANK_ID
10T9CSU89I UNII
155817470 PUBCHEM_CID
114260 RXNORM
17041 MMSL
336918 MMSL
d04828 MMSL
002142 NDDF
004944 NDDF
109198008 SNOMEDCT_US
398823001 SNOMEDCT_US
425438001 SNOMEDCT_US
D019379 MESH_DESCRIPTOR_UI
C0070093 UMLSCUI
CHEMBL1201549 ChEMBL_ID

Pharmaceutical products:

ProductCategoryIngredientsNDCFormQuantityRouteMarketingLabel
Forteo HUMAN PRESCRIPTION DRUG LABEL 1 0002-8400 INJECTION, SOLUTION 250 ug SUBCUTANEOUS NDA 35 sections
teriparatide HUMAN PRESCRIPTION DRUG LABEL 1 47781-652 INJECTION, SOLUTION 250 ug SUBCUTANEOUS NDA 30 sections