teriparatide 🐶 Veterinary Use | Indications/Contra | FAERs-F | FAERs-M | Orange Bk | PK/Tox | Related Drugs | BioActivity |

Stem definitionDrug idCAS RN
peptides and glycopeptides 4514 52232-67-4

Description:

MoleculeDescription

Molfile Inchi Smiles

Synonyms:

  • teriparatide recombinant human
  • forsteo
  • teriparatide
  • teriparatide acetate
  • hPTH 1-34
  • parathar
A polypeptide that consists of the 1-34 amino-acid fragment of human PARATHYROID HORMONE, the biologically active N-terminal region. The acetate form is given by intravenous infusion in the differential diagnosis of HYPOPARATHYROIDISM and PSEUDOHYPOPARATHYROIDISM. (Reynolds JEF(Ed): Martindale: The Extra Pharmacopoeia (electronic version). Micromedex, Inc, Englewood, CO, 1995)
  • Molecular weight: 4117.77
  • Formula: C181H291N55O51S2
  • CLOGP:
  • LIPINSKI: None
  • HAC: 106
  • HDO: 60
  • TPSA: 1752.65
  • ALOGS:
  • ROTB: 144

Drug dosage:

DoseUnitRoute
20 mcg P

ADMET properties:

PropertyValueReference
Vd (Volume of distribution) 0.17 L/kg Lombardo F, Berellini G, Obach RS
CL (Clearance) 21.40 mL/min/kg Lombardo F, Berellini G, Obach RS
t_half (Half-life) 0.14 hours Lombardo F, Berellini G, Obach RS

Predicted pharmacokinetic/toxicological properties (PK-AZ):

None

Approvals:

DateAgencyCompanyOrphan
July 23, 2019 PMDA Eli Lilly Japan
June 10, 2003 EMA
Nov. 26, 2002 FDA LILLY

FDA Adverse Event Reporting System (Female)

MedDRA adverse event termLikelihood ratioLikelihood ratio thresholdPatients taking drug having adverse eventPatients taking drug not having adverse eventPatients not taking drug having adverse eventPatients not taking drug not having adverse event
Fall 1606.06 13.37 1911 68036 479899 90078601
Product complaint 1366.62 13.37 479 69468 13021 90545479
Blood calcium increased 995.51 13.37 368 69579 11690 90546810
Hip fracture 899.83 13.37 461 69486 32616 90525884
Bone pain 867.38 13.37 560 69387 61423 90497077
Therapy cessation 587.44 13.37 360 69587 36001 90522499
Injection site haemorrhage 547.92 13.37 315 69632 28003 90530497
Spinal fracture 541.79 13.37 287 69660 21729 90536771
Muscle spasms 461.95 13.37 752 69195 251131 90307369
Hospitalisation 458.44 13.37 529 69418 127571 90430929
Dizziness 457.91 13.37 1235 68712 588049 89970451
Femur fracture 457.03 13.37 337 69610 45745 90512755
Product storage error 453.67 13.37 248 69699 19993 90538507
Drug ineffective 411.23 13.37 285 69662 1384013 89174487
Hypercalcaemia 396.03 13.37 275 69672 33965 90524535
Pelvic fracture 376.13 13.37 199 69748 15020 90543480
Injection site erythema 369.61 13.37 417 69530 98085 90460415
Fracture 360.13 13.37 220 69727 21856 90536644
Back pain 354.57 13.37 766 69181 316409 90242091
Off label use 310.98 13.37 239 69708 1102013 89456487
Wrist fracture 310.74 13.37 177 69770 15447 90543053
Pain in extremity 306.78 13.37 901 69046 449628 90108872
Injection site bruising 303.06 13.37 280 69667 52027 90506473
Feeling abnormal 250.64 13.37 457 69490 166778 90391722
Rib fracture 247.89 13.37 187 69760 26248 90532252
Bone density decreased 245.53 13.37 158 69789 17187 90541313
Infusion related reaction 241.30 13.37 22 69925 416758 90141742
Injection site haematoma 234.22 13.37 112 69835 6810 90551690
Contraindicated product administered 227.01 13.37 4 69943 320135 90238365
Drug intolerance 224.25 13.37 38 69909 447553 90110947
Upper limb fracture 223.35 13.37 162 69785 21416 90537084
Spinal operation 209.47 13.37 118 69829 10078 90548422
Injection site pain 207.02 13.37 431 69516 173268 90385232
Synovitis 206.27 13.37 12 69935 329740 90228760
Glossodynia 197.40 13.37 13 69934 321766 90236734
Product dose omission issue 194.93 13.37 580 69367 291107 90267393
Hand deformity 194.26 13.37 8 69939 296354 90262146
Treatment failure 193.38 13.37 10 69937 303918 90254582
Arthralgia 183.42 13.37 1125 68822 777397 89781103
Device operational issue 175.66 13.37 54 69893 956 90557544
Nephrolithiasis 170.83 13.37 200 69747 48885 90509615
Chronic obstructive pulmonary disease 168.12 13.37 244 69703 73585 90484915
Systemic lupus erythematosus 167.94 13.37 37 69910 361859 90196641
Femoral neck fracture 166.92 13.37 102 69845 10131 90548369
Hepatic enzyme increased 161.21 13.37 40 69907 360696 90197804
Exposure during pregnancy 161.21 13.37 5 69942 238405 90320095
Lumbar vertebral fracture 160.52 13.37 89 69858 7369 90551131
Asthenia 159.73 13.37 823 69124 532928 90025572
Pericarditis 159.70 13.37 13 69934 270138 90288362
Compression fracture 157.32 13.37 93 69854 8696 90549804
Toxicity to various agents 156.74 13.37 19 69928 287827 90270673
Helicobacter infection 156.18 13.37 4 69943 226846 90331654
Duodenal ulcer perforation 155.87 13.37 3 69944 221285 90337215
Therapeutic product effect decreased 151.93 13.37 18 69929 277553 90280947
Wound 148.86 13.37 27 69920 302953 90255547
Product use in unapproved indication 148.85 13.37 38 69909 336198 90222302
Spinal compression fracture 148.15 13.37 110 69837 15068 90543432
Bone disorder 148.09 13.37 131 69816 22989 90535511
Therapy interrupted 143.39 13.37 185 69762 49923 90508577
Foot fracture 141.74 13.37 136 69811 26470 90532030
Drug hypersensitivity 141.36 13.37 92 69855 463517 90094983
Folliculitis 139.19 13.37 4 69943 204349 90354151
Vertebroplasty 131.59 13.37 35 69912 357 90558143
Stomatitis 129.62 13.37 27 69920 274671 90283829
Surgery 128.87 13.37 166 69781 44721 90513779
Blood alkaline phosphatase increased 127.50 13.37 171 69776 47908 90510592
Heart rate increased 125.00 13.37 272 69675 112630 90445870
Death 124.19 13.37 686 69261 455865 90102635
Myalgia 122.35 13.37 354 69593 174771 90383729
Type 2 diabetes mellitus 122.30 13.37 9 69938 203235 90355265
Palpitations 121.35 13.37 302 69645 136426 90422074
Product use issue 120.32 13.37 52 69895 329867 90228633
Neutropenia 119.61 13.37 16 69931 224888 90333612
Lower respiratory tract infection 115.48 13.37 26 69921 250633 90307867
Thoracic vertebral fracture 114.20 13.37 64 69883 5410 90553090
Humerus fracture 114.05 13.37 79 69868 9706 90548794
Cerebrovascular accident 114.01 13.37 277 69670 123256 90435244
Wheezing 113.14 13.37 23 69924 238057 90320443
Muscle injury 111.72 13.37 6 69941 176648 90381852
Therapeutic product effect incomplete 110.07 13.37 11 69936 193885 90364615
Liver injury 107.23 13.37 6 69941 170561 90387939
Nausea 102.69 13.37 1306 68641 1109010 89449490
Tibia fracture 102.68 13.37 62 69885 6025 90552475
Myocardial infarction 101.41 13.37 241 69706 105731 90452769
Febrile neutropenia 101.33 13.37 5 69942 158344 90400156
Ankle fracture 100.79 13.37 100 69847 20270 90538230
Pyrexia 100.51 13.37 226 69721 660259 89898241
Intentional product use issue 96.93 13.37 24 69923 216868 90341632
Device malfunction 96.50 13.37 99 69848 20878 90537622
Completed suicide 94.71 13.37 4 69943 145054 90413446
Cardiac disorder 93.54 13.37 162 69785 56710 90501790
Irritable bowel syndrome 90.69 13.37 24 69923 207424 90351076
Osteitis deformans 89.76 13.37 23 69924 200 90558300
Swelling 88.79 13.37 116 69831 418942 90139558
Gait disturbance 88.60 13.37 417 69530 260079 90298421
Blister 87.06 13.37 44 69903 254954 90303546
Acute kidney injury 85.43 13.37 73 69874 320314 90238186
Recalled product 84.64 13.37 34 69913 1354 90557146
Condition aggravated 84.02 13.37 212 69735 595333 89963167
Fibromyalgia 80.94 13.37 29 69918 206240 90352260
Vitamin D decreased 76.96 13.37 68 69879 11911 90546589
Patella fracture 76.58 13.37 38 69909 2505 90555995
Hypersensitivity 76.31 13.37 147 69800 454530 90103970
Breast cancer 75.50 13.37 143 69804 53618 90504882
Balance disorder 75.38 13.37 204 69743 96876 90461624
Pathological fracture 74.69 13.37 61 69886 9599 90548901
Stress fracture 74.32 13.37 58 69889 8553 90549947
Rash 73.18 13.37 341 69606 795759 89762741
Thrombocytopenia 72.78 13.37 35 69912 208690 90349810
Drug interaction 71.26 13.37 65 69882 276388 90282112
Sleep disorder due to general medical condition, insomnia type 71.23 13.37 8 69939 128686 90429814
Disease progression 70.61 13.37 17 69930 156598 90401902
Atypical femur fracture 68.24 13.37 49 69898 6372 90552128
Nervousness 68.14 13.37 106 69841 33950 90524550
Head injury 66.53 13.37 100 69847 31088 90527412
Injury 65.94 13.37 35 69912 197314 90361186
Blood parathyroid hormone increased 65.82 13.37 38 69909 3399 90555101
Hand fracture 65.31 13.37 49 69898 6816 90551684
Arrhythmia 64.98 13.37 117 69830 42215 90516285
Psoriasis 64.75 13.37 17 69930 147737 90410763
Rheumatoid arthritis 63.68 13.37 114 69833 362500 90196000
Discomfort 63.30 13.37 71 69876 274264 90284236
General physical health deterioration 62.94 13.37 111 69836 355004 90203496
Fracture nonunion 62.43 13.37 32 69915 2260 90556240
Joint swelling 62.14 13.37 191 69756 503109 90055391
Fear 61.63 13.37 70 69877 16552 90541948
Calciphylaxis 61.14 13.37 36 69911 3340 90555160
Malignant neoplasm progression 60.80 13.37 6 69941 106864 90451636
Sinusitis 60.11 13.37 108 69839 342980 90215520
Obesity 59.82 13.37 6 69941 105501 90452999
Body height decreased 59.74 13.37 59 69888 11890 90546610
Transient ischaemic attack 59.58 13.37 114 69833 43062 90515438
Loss of consciousness 59.48 13.37 240 69707 139998 90418502
Musculoskeletal discomfort 59.25 13.37 77 69870 20914 90537586
Bone fissure 58.28 13.37 20 69927 508 90557992
C-reactive protein increased 57.96 13.37 34 69913 181355 90377145
Oedema 57.95 13.37 42 69905 200253 90358247
Abdominal discomfort 57.61 13.37 183 69764 477145 90081355
Peripheral swelling 57.46 13.37 148 69799 412958 90145542
Cervical vertebral fracture 54.15 13.37 33 69914 3260 90555240
Grip strength decreased 53.18 13.37 5 69942 92571 90465929
Fractured sacrum 52.33 13.37 29 69918 2398 90556102
Arthropathy 51.86 13.37 130 69817 366112 90192388
Joint range of motion decreased 51.64 13.37 20 69927 135623 90422877
Osteonecrosis 51.56 13.37 81 69866 26160 90532340
Intentional overdose 51.51 13.37 6 69941 93828 90464672
Liver function test increased 50.34 13.37 4 69943 84851 90473649
Injection site rash 48.03 13.37 75 69872 24098 90534402
Post procedural complication 47.85 13.37 66 69881 18976 90539524
Ulna fracture 46.99 13.37 22 69925 1275 90557225
Hip surgery 46.86 13.37 33 69914 4162 90554338
Prescribed underdose 46.04 13.37 3 69944 75016 90483484
Device failure 46.01 13.37 40 69907 6857 90551643
Drug abuse 45.87 13.37 5 69942 82342 90476158
Urine calcium increased 45.67 13.37 11 69936 72 90558428
Radius fracture 45.61 13.37 32 69915 4012 90554488
Cardiac failure congestive 45.15 13.37 173 69774 98521 90459979
Malaise 44.35 13.37 666 69281 585320 89973180
Alopecia 44.24 13.37 214 69733 494857 90063643
Therapeutic response decreased 44.01 13.37 8 69939 89721 90468779
Multiple fractures 43.75 13.37 45 69902 9517 90548983
Heart rate irregular 43.70 13.37 72 69875 24196 90534304
Lung neoplasm malignant 43.69 13.37 72 69875 24201 90534299
Breast cancer in situ 43.68 13.37 23 69924 1717 90556783
Blood calcium abnormal 43.66 13.37 24 69923 1953 90556547
White blood cell count decreased 43.39 13.37 39 69908 167070 90391430
Leukopenia 43.34 13.37 12 69935 100698 90457802
Intestinal obstruction 42.83 13.37 91 69856 37040 90521460
Device defective 42.65 13.37 29 69918 3457 90555043
Blood cholesterol increased 42.56 13.37 59 69888 207953 90350547
Sleep disorder 41.70 13.37 55 69892 197975 90360525
Constipation 40.80 13.37 362 69585 280033 90278467
Gastrointestinal disorder 40.44 13.37 86 69861 256601 90301899
Peripheral venous disease 40.06 13.37 8 69939 83913 90474587
Accident 39.81 13.37 37 69910 6917 90551583
Vertigo 39.31 13.37 131 69816 69680 90488820
Inflammation 39.26 13.37 48 69899 178544 90379956
Osteoporotic fracture 38.93 13.37 31 69916 4705 90553795
Pain 38.73 13.37 1024 68923 995317 89563183
Anaphylactic reaction 38.47 13.37 10 69937 87514 90470986
Injury associated with device 38.38 13.37 30 69917 4434 90554066
Visual acuity reduced 37.59 13.37 66 69881 23344 90535156
Fibula fracture 37.57 13.37 29 69918 4208 90554292
Autoimmune disorder 37.30 13.37 7 69940 76737 90481763
Plasma cell myeloma 37.04 13.37 91 69856 40737 90517763
N-telopeptide urine increased 37.01 13.37 6 69941 0 90558500
Osteocalcin increased 37.01 13.37 6 69941 0 90558500
Movement disorder 36.86 13.37 74 69873 28945 90529555
Calcinosis 36.78 13.37 24 69923 2671 90555829
Tremor 36.19 13.37 222 69725 152951 90405549
Prescribed overdose 36.16 13.37 15 69932 97610 90460890
Hypercalciuria 36.03 13.37 13 69934 384 90558116
Medication error 35.98 13.37 145 69802 84507 90473993
Neutrophil count decreased 35.91 13.37 6 69941 71526 90486974
Colon cancer 35.44 13.37 43 69904 10901 90547599
Wound infection 35.34 13.37 19 69928 106383 90452117
Clavicle fracture 35.15 13.37 27 69920 3889 90554611
Emphysema 34.95 13.37 45 69902 12110 90546390
Pain in jaw 34.43 13.37 98 69849 47887 90510613
Urinary tract infection 34.40 13.37 374 69573 305258 90253242
Hyperparathyroidism 34.40 13.37 25 69922 3312 90555188
Suicide attempt 34.34 13.37 8 69939 75391 90483109
Musculoskeletal stiffness 34.13 13.37 116 69831 296416 90262084
Weight decreased 34.02 13.37 445 69502 379465 90179035
Facial bones fracture 34.00 13.37 26 69921 3721 90554779
Ill-defined disorder 33.44 13.37 57 69890 184834 90373666
Dementia Alzheimer's type 33.26 13.37 16 69931 985 90557515
Hypoacusis 32.99 13.37 69 69878 27781 90530719
Urticaria 32.91 13.37 127 69820 312607 90245893
Diarrhoea 32.45 13.37 520 69427 938670 89619830
Dysstasia 31.96 13.37 64 69883 24988 90533512
Liver disorder 31.84 13.37 28 69919 121241 90437259
Nasopharyngitis 31.33 13.37 185 69762 406919 90151581
Headache 31.01 13.37 878 69069 861868 89696632
Platelet count decreased 30.97 13.37 36 69911 136933 90421567
Infection 30.90 13.37 159 69788 361935 90196565
Abdominal pain 30.89 13.37 179 69768 395542 90162958
Breast calcifications 30.84 13.37 17 69930 1391 90557109
Vein disorder 30.81 13.37 29 69918 5507 90552993
Nerve compression 30.20 13.37 39 69908 10527 90547973
Neoplasm malignant 30.19 13.37 75 69872 33805 90524695
Spinal disorder 30.13 13.37 41 69906 11638 90546862
Pancytopenia 30.11 13.37 29 69918 120234 90438266
Spinal deformity 30.01 13.37 16 69931 1225 90557275
Influenza 29.90 13.37 197 69750 139067 90419433
Musculoskeletal chest pain 29.49 13.37 60 69887 23690 90534810
Hepatitis 29.39 13.37 9 69938 70730 90487770
Incorrect product administration duration 29.13 13.37 53 69894 19269 90539231
Parkinson's disease 29.06 13.37 15 69932 1075 90557425
Groin pain 28.71 13.37 41 69906 12172 90546328
Sternal fracture 28.34 13.37 21 69926 2866 90555634
Bursitis 28.29 13.37 36 69911 131618 90426882
Complication associated with device 27.63 13.37 52 69895 19397 90539103
Bone scan abnormal 27.48 13.37 11 69936 434 90558066
Dehydration 27.22 13.37 249 69698 194198 90364302
Jaw disorder 26.96 13.37 27 69920 5532 90552968
Atrial fibrillation 26.88 13.37 186 69761 133425 90425075
Wrong technique in product usage process 26.83 13.37 118 69829 71453 90487047
Drug ineffective for unapproved indication 26.76 13.37 9 69938 66635 90491865
Therapy non-responder 26.74 13.37 40 69907 136664 90421836
Limb discomfort 26.59 13.37 77 69870 37983 90520517
Addison's disease 26.44 13.37 7 69940 70 90558430
Accidental underdose 26.20 13.37 14 69933 1077 90557423
Contusion 25.80 13.37 302 69645 250914 90307586
Cystitis 25.78 13.37 111 69836 66607 90491893
Joint injury 25.70 13.37 69 69878 32595 90525905
Pulmonary fibrosis 25.68 13.37 27 69920 107476 90451024
Bone cancer 25.66 13.37 16 69931 1646 90556854
Hypercholesterolaemia 25.64 13.37 24 69923 100868 90457632
Leukaemia 25.61 13.37 25 69922 4967 90553533
Ilium fracture 25.59 13.37 8 69939 150 90558350
Dislocation of vertebra 25.36 13.37 6 69941 55962 90502538
Hernial eventration 25.35 13.37 5 69942 10 90558490
Spinal stenosis 25.27 13.37 47 69900 17377 90541123
Injection site irritation 25.18 13.37 27 69920 5988 90552512
Product quality issue 25.14 13.37 15 69932 79310 90479190
Onychomadesis 25.10 13.37 3 69944 45995 90512505
Posture abnormal 25.01 13.37 19 69928 2692 90555808
Night sweats 24.88 13.37 38 69909 128728 90429772
Cementoplasty 24.67 13.37 4 69943 0 90558500
Pneumonia 24.19 13.37 654 69293 637405 89921095
Blood pressure decreased 24.04 13.37 118 69829 74777 90483723
Mass 23.83 13.37 43 69904 15534 90542966
Kyphosis 23.83 13.37 19 69928 2889 90555611
Osteonecrosis of jaw 23.47 13.37 75 69872 39028 90519472
Blood sodium decreased 23.43 13.37 60 69887 27553 90530947
Bone erosion 23.41 13.37 6 69941 53015 90505485
Hallucination, synaesthetic 23.04 13.37 6 69941 56 90558444
Extrasystoles 22.99 13.37 25 69922 5632 90552868
Injection site discolouration 22.96 13.37 32 69915 9288 90549212
Face injury 22.78 13.37 21 69926 3884 90554616
Bradycardia 22.44 13.37 19 69928 83828 90474672
Hepatic cancer 22.38 13.37 23 69924 4858 90553642
Frequent bowel movements 22.32 13.37 8 69939 56927 90501573
Calcium ionised increased 22.31 13.37 8 69939 232 90558268
Neuropathy peripheral 22.31 13.37 45 69902 136925 90421575
Enchondromatosis 22.26 13.37 7 69940 134 90558366
Blood calcium decreased 22.00 13.37 62 69885 30120 90528380
Delirium 21.94 13.37 29 69918 104330 90454170
Tetany 21.43 13.37 17 69930 2567 90555933
Vomiting 21.38 13.37 455 69492 787838 89770662
Skeletal injury 21.32 13.37 13 69934 1286 90557214
Gammopathy 21.30 13.37 7 69940 155 90558345
Scoliosis 21.08 13.37 30 69917 8877 90549623
Fracture malunion 21.05 13.37 7 69940 161 90558339
Angioedema 20.94 13.37 12 69935 64864 90493636
Joint arthroplasty 20.87 13.37 19 69928 3458 90555042
Rehabilitation therapy 20.83 13.37 15 69932 1959 90556541
Extraskeletal ossification 20.81 13.37 7 69940 167 90558333
Cardiac pacemaker insertion 20.63 13.37 21 69926 4386 90554114
Injection site urticaria 20.61 13.37 44 69903 17967 90540533
Injection site streaking 20.59 13.37 5 69942 34 90558466
Bronchitis 20.47 13.37 194 69753 152733 90405767
Thrombosis 20.45 13.37 111 69836 73140 90485360
Alanine aminotransferase increased 20.03 13.37 38 69909 118300 90440200
Open fracture 20.01 13.37 9 69938 475 90558025
Hot flush 20.01 13.37 95 69852 59393 90499107
Lumbar spinal stenosis 19.79 13.37 23 69924 5574 90552926
Cardiac flutter 19.74 13.37 21 69926 4617 90553883
Atypical fracture 19.73 13.37 11 69936 920 90557580
Neck pain 19.69 13.37 153 69794 113810 90444690
Neoplasm 19.63 13.37 29 69918 8874 90549626
Ligament sprain 19.47 13.37 38 69909 14561 90543939
Illness 19.12 13.37 21 69926 81948 90476552
Angina pectoris 19.03 13.37 70 69877 39090 90519410
Knee operation 18.89 13.37 25 69922 6911 90551589
Immunodeficiency 18.88 13.37 5 69942 43229 90515271
Laryngeal pain 18.78 13.37 20 69927 4402 90554098
Kidney infection 18.66 13.37 53 69894 25863 90532637
Upper respiratory tract infection 18.56 13.37 45 69902 128273 90430227
Wrong product stored 18.50 13.37 3 69944 0 90558500
Traumatic shock 18.50 13.37 3 69944 0 90558500
Ear infection 18.44 13.37 16 69931 69759 90488741
Metabolic acidosis 18.40 13.37 10 69937 55666 90502834
Hiatus hernia 18.39 13.37 52 69895 25309 90533191
Red blood cell sedimentation rate increased 18.35 13.37 22 69925 82573 90475927
Suicidal ideation 18.26 13.37 18 69929 73837 90484663
Periprosthetic fracture 18.24 13.37 9 69938 586 90557914
Hypokalaemia 18.17 13.37 47 69900 131069 90427431
Cataract operation 18.01 13.37 23 69924 6140 90552360
Urinary bladder polyp 17.98 13.37 5 69942 61 90558439
Dry mouth 17.93 13.37 77 69870 183982 90374518
Inguinal hernia 17.82 13.37 14 69933 2084 90556416
Pollakiuria 17.75 13.37 61 69886 32944 90525556
Drug eruption 17.70 13.37 3 69944 35404 90523096
Fracture delayed union 17.66 13.37 15 69932 2491 90556009
Limb injury 17.62 13.37 59 69888 31449 90527051
Dyspnoea 17.56 13.37 532 69415 880423 89678077
Renal stone removal 17.42 13.37 6 69941 154 90558346
Wrong technique in device usage process 17.40 13.37 22 69925 5813 90552687
Serotonin syndrome 17.29 13.37 4 69943 37883 90520617
Epilepsy 17.12 13.37 23 69924 82183 90476317
Pseudarthrosis 17.11 13.37 8 69939 462 90558038
Hip arthroplasty 17.08 13.37 109 69838 76099 90482401
Parathyroid tumour benign 17.00 13.37 10 69937 926 90557574
Colitis ulcerative 16.95 13.37 13 69934 60253 90498247
Onychomycosis 16.95 13.37 4 69943 37372 90521128
Laryngitis 16.94 13.37 9 69938 50744 90507756
Burning sensation 16.94 13.37 95 69852 63357 90495143
Muscle disorder 16.89 13.37 21 69926 5458 90553042
Jaw fracture 16.80 13.37 15 69932 2663 90555837
Bone development abnormal 16.79 13.37 5 69942 79 90558421
Drug reaction with eosinophilia and systemic symptoms 16.78 13.37 6 69941 42752 90515748
Cataract 16.71 13.37 104 69843 71988 90486512
Empyema 16.69 13.37 14 69933 2286 90556214
Pruritus 16.64 13.37 306 69641 541219 90017281
Spondylolisthesis 16.55 13.37 18 69929 4057 90554443
Basosquamous carcinoma of skin 16.43 13.37 3 69944 3 90558497
Multiple sclerosis relapse 16.42 13.37 10 69937 52295 90506205
Clostridial infection 16.30 13.37 19 69928 4617 90553883
Dystrophic calcification 16.29 13.37 6 69941 188 90558312
Bone graft 16.21 13.37 10 69937 1010 90557490
Oestrogen receptor assay positive 16.03 13.37 8 69939 534 90557966
Loose tooth 16.02 13.37 17 69930 3726 90554774
Growing pains 15.91 13.37 4 69943 32 90558468
Accidental overdose 15.86 13.37 53 69894 28220 90530280
Thrombophlebitis 15.68 13.37 19 69928 4809 90553691
Impaired healing 15.67 13.37 111 69836 234088 90324412
Gastric disorder 15.66 13.37 59 69888 33325 90525175
Blood bilirubin increased 15.59 13.37 7 69940 43463 90515037
Arterial disorder 15.56 13.37 11 69936 1395 90557105
Bone marrow failure 15.53 13.37 3 69944 32218 90526282
Breast cancer female 15.48 13.37 35 69912 14851 90543649
Manufacturing product shipping issue 15.46 13.37 5 69942 105 90558395
Tooth disorder 15.46 13.37 56 69891 31034 90527466
Dementia 15.46 13.37 47 69900 23814 90534686
Migraine 15.44 13.37 85 69862 190307 90368193
Fatigue 15.37 13.37 1060 68887 1152963 89405537
Prosthesis implantation 15.29 13.37 5 69942 109 90558391
Hernia hiatus repair 15.25 13.37 6 69941 226 90558274
N-telopeptide urine decreased 15.21 13.37 3 69944 6 90558494
Cardiac pacemaker replacement 15.09 13.37 7 69940 397 90558103
Thyroid neoplasm 15.02 13.37 17 69930 4004 90554496
Concussion 14.95 13.37 29 69918 11062 90547438
Cholelithiasis 14.95 13.37 80 69867 52426 90506074
Hypoaesthesia 14.80 13.37 163 69784 314047 90244453
Agitation 14.77 13.37 18 69929 67080 90491420
Limb crushing injury 14.77 13.37 6 69941 246 90558254
Acetabulum fracture 14.75 13.37 7 69940 418 90558082
Tooth fracture 14.67 13.37 31 69916 12569 90545931
Cardiac valve disease 14.66 13.37 18 69929 4617 90553883
Bone density abnormal 14.61 13.37 17 69930 4123 90554377
Osteoma 14.60 13.37 4 69943 46 90558454
Hair growth abnormal 14.52 13.37 16 69931 3660 90554840
Loss of personal independence in daily activities 14.48 13.37 55 69892 136050 90422450
Intentional dose omission 14.43 13.37 38 69909 17745 90540755
Blood urine 14.37 13.37 7 69940 443 90558057
Back disorder 14.34 13.37 48 69899 25583 90532917
Tooth resorption 14.30 13.37 4 69943 50 90558450
Medical device implantation 14.18 13.37 8 69939 685 90557815
Surgical procedure repeated 14.12 13.37 6 69941 276 90558224
Fractured coccyx 14.09 13.37 10 69937 1277 90557223
Hyperparathyroidism primary 14.06 13.37 7 69940 465 90558035
Sedation 14.05 13.37 10 69937 48161 90510339
Brain neoplasm 13.97 13.37 18 69929 4846 90553654
Disability 13.94 13.37 7 69940 40738 90517762
Skin laceration 13.90 13.37 48 69899 25987 90532513
Oral candidiasis 13.87 13.37 5 69942 35450 90523050
Localised infection 13.87 13.37 57 69890 33505 90524995
Aortic aneurysm 13.86 13.37 17 69930 4358 90554142
Medical device removal 13.77 13.37 10 69937 1323 90557177
Drug delivery system issue 13.66 13.37 5 69942 154 90558346
Cardiac operation 13.58 13.37 16 69931 3933 90554567
Dysgeusia 13.57 13.37 78 69869 52482 90506018
Lung adenocarcinoma 13.55 13.37 19 69928 5546 90552954
Primary biliary cholangitis 13.50 13.37 10 69937 1364 90557136
Breast enlargement 13.39 13.37 11 69936 1744 90556756
Syncope 13.39 13.37 159 69788 132504 90425996

FDA Adverse Event Reporting System (Male)

MedDRA adverse event termLikelihood ratioLikelihood ratio thresholdPatients taking drug having adverse eventPatients taking drug not having adverse eventPatients not taking drug having adverse eventPatients not taking drug not having adverse event
Hip fracture 144.09 21.83 60 6516 13412 42601347
Product complaint 111.83 21.83 40 6536 5937 42608822
Hospitalisation 109.44 21.83 91 6485 74239 42540520
Bone pain 103.22 21.83 57 6519 23735 42591024
Fall 101.93 21.83 151 6425 234369 42380390
Spinal fracture 85.20 21.83 37 6539 9153 42605606
Therapy cessation 75.23 21.83 44 6532 20406 42594353
Spinal operation 63.26 21.83 24 6552 4196 42610563
Death 61.47 21.83 185 6391 471000 42143759
Device operational issue 56.06 21.83 12 6564 257 42614502
Back pain 52.55 21.83 85 6491 141691 42473068
Arthralgia 51.74 21.83 104 6472 205134 42409625
Bone density decreased 49.85 21.83 17 6559 2189 42612570
Muscle spasms 45.47 21.83 61 6515 85983 42528776
Therapy interrupted 45.18 21.83 33 6543 22217 42592542
Vertebroplasty 41.58 21.83 7 6569 37 42614722
Thoracic vertebral fracture 41.23 21.83 15 6561 2333 42612426
Pneumonia 39.14 21.83 148 6428 422001 42192758
Pain in extremity 38.71 21.83 77 6499 150527 42464232
Femur fracture 38.43 21.83 22 6554 9790 42604969
Injection site pain 36.86 21.83 45 6531 57753 42557006
Dizziness 35.28 21.83 101 6475 249153 42365606
Acute kidney injury 33.19 21.83 8 6568 367329 42247430
Injection site erythema 32.32 21.83 26 6550 20169 42594590
Injection site haemorrhage 32.31 21.83 21 6555 11715 42603044
Osteoporotic fracture 31.64 21.83 11 6565 1500 42613259
Fracture 31.28 21.83 18 6558 8085 42606674
Product storage error 30.83 21.83 20 6556 11120 42603639
Blood calcium increased 30.57 21.83 18 6558 8436 42606323
Injection site bruising 30.21 21.83 20 6556 11505 42603254
Spinal compression fracture 29.90 21.83 17 6559 7466 42607293
Upper limb fracture 28.80 21.83 15 6561 5541 42609218
Pain 27.89 21.83 92 6484 244756 42370003
Atypical femur fracture 26.95 21.83 7 6569 351 42614408
Lumbar vertebral fracture 26.87 21.83 12 6564 3167 42611592
Device malfunction 26.65 21.83 19 6557 12308 42602451
Nephrolithiasis 23.99 21.83 29 6547 36801 42577958
Accidental underdose 22.60 21.83 7 6569 664 42614095
Incorrect product administration duration 22.53 21.83 13 6563 5867 42608892
Hypercalcaemia 22.23 21.83 20 6556 18038 42596721
Chronic obstructive pulmonary disease 22.19 21.83 37 6539 63077 42551682

FDA Adverse Event Reporting System (Geriatric)

MedDRA adverse event termLikelihood ratioLikelihood ratio thresholdPatients taking drug having adverse eventPatients taking drug not having adverse eventPatients not taking drug having adverse eventPatients not taking drug not having adverse event
Product complaint 1659.03 12.91 483 45632 13489 110529695
Fall 910.76 12.91 1184 44931 602298 109940886
Bone pain 565.28 12.91 347 45768 64786 110478398
Blood calcium increased 551.04 12.91 226 45889 17814 110525370
Hip fracture 480.07 12.91 252 45863 34899 110508285
Injection site haemorrhage 451.67 12.91 237 45878 32791 110510393
Spinal fracture 451.38 12.91 210 45905 22423 110520761
Product storage error 422.15 12.91 198 45917 21530 110521654
Therapy cessation 371.36 12.91 232 45883 44625 110498559
Injection site erythema 345.93 12.91 298 45817 93878 110449306
Muscle spasms 324.90 12.91 484 45631 277673 110265511
Dizziness 320.18 12.91 817 45298 697376 109845808
Femur fracture 292.16 12.91 199 45916 44270 110498914
Hypercalcaemia 288.18 12.91 201 45914 46456 110496728
Injection site bruising 287.01 12.91 208 45907 51055 110492129
Back pain 278.87 12.91 530 45585 370466 110172718
Wrist fracture 233.49 12.91 116 45999 14301 110528883
Pain in extremity 232.16 12.91 579 45536 486539 110056645
Feeling abnormal 214.42 12.91 317 45798 180394 110362790
Pelvic fracture 209.05 12.91 107 46008 14047 110529137
Drug ineffective 208.87 12.91 197 45918 1520343 109022841
Therapy interrupted 204.16 12.91 168 45947 49654 110493530
Injection site pain 198.11 12.91 303 45812 177619 110365565
Spinal operation 191.77 12.91 93 46022 10879 110532305
Off label use 188.23 12.91 210 45905 1499975 109043209
Bone density decreased 182.68 12.91 102 46013 15940 110527244
Hospitalisation 179.21 12.91 257 45858 142236 110400948
Arthralgia 178.49 12.91 719 45396 778913 109764271
Fracture 172.52 12.91 115 46000 24673 110518511
Upper limb fracture 162.72 12.91 104 46011 20784 110522400
Femoral neck fracture 148.83 12.91 82 46033 12485 110530699
Rib fracture 147.04 12.91 118 45997 33652 110509532
Toxicity to various agents 144.32 12.91 16 46099 480539 110062645
Lumbar vertebral fracture 140.58 12.91 71 46044 9060 110534124
Vertebroplasty 129.76 12.91 30 46085 322 110542862
Acute kidney injury 123.98 12.91 55 46060 635375 109907809
Product dose omission issue 122.18 12.91 352 45763 321430 110221754
Neutropenia 121.76 12.91 9 46106 374611 110168573
Febrile neutropenia 117.92 12.91 3 46112 316764 110226420
Spinal compression fracture 115.31 12.91 80 46035 18312 110524872
Foot fracture 114.92 12.91 91 46024 25455 110517729
Thoracic vertebral fracture 109.09 12.91 54 46061 6601 110536583
Nephrolithiasis 102.26 12.91 132 45983 66080 110477104
Atypical femur fracture 100.57 12.91 50 46065 6169 110537015
Product use in unapproved indication 100.18 12.91 31 46084 447346 110095838
Drug intolerance 96.89 12.91 25 46090 406487 110136697
Compression fracture 92.13 12.91 54 46061 9245 110533939
Infusion related reaction 91.68 12.91 23 46092 381139 110162045
Synovitis 90.74 12.91 6 46109 274086 110269098
Asthenia 88.75 12.91 540 45575 688459 109854725
Nausea 88.44 12.91 843 45272 1234847 109308337
Contraindicated product administered 86.62 12.91 4 46111 248263 110294921
Treatment failure 86.37 12.91 8 46107 277226 110265958
Tibia fracture 83.61 12.91 45 46070 6540 110536644
Blood alkaline phosphatase increased 81.96 12.91 123 45992 70812 110472372
Palpitations 81.67 12.91 195 45920 159017 110384167
Completed suicide 81.14 12.91 5 46110 242376 110300808
Heart rate increased 79.06 12.91 181 45934 143653 110399531
Pathological fracture 76.99 12.91 53 46062 11979 110531205
Humerus fracture 74.99 12.91 50 46065 10726 110532458
Hand deformity 71.68 12.91 5 46110 218501 110324683
Pain 70.91 12.91 657 45458 954298 109588886
Pyrexia 70.73 12.91 170 45945 898095 109645089
Stomatitis 69.60 12.91 14 46101 270228 110272956
Calciphylaxis 68.71 12.91 34 46081 4153 110539031
Drug interaction 68.01 12.91 65 46050 500118 110043066
Bone disorder 67.66 12.91 62 46053 21130 110522054
Surgery 66.41 12.91 84 46031 41199 110501985
Therapeutic product effect incomplete 65.75 12.91 8 46107 223797 110319387
Pericarditis 63.96 12.91 8 46107 219106 110324078
Hepatic enzyme increased 63.72 12.91 27 46088 320865 110222319
Thrombocytopenia 63.66 12.91 33 46082 348852 110194332
Helicobacter infection 63.21 12.91 3 46112 181874 110361310
Disease progression 62.10 12.91 13 46102 244021 110299163
Chronic obstructive pulmonary disease 61.79 12.91 139 45976 109019 110434165
Cerebrovascular accident 61.78 12.91 191 45924 181093 110362091
Body height decreased 61.69 12.91 44 46071 10519 110532665
Duodenal ulcer perforation 61.53 12.91 3 46112 177697 110365487
Osteitis deformans 61.08 12.91 15 46100 212 110542972
Glossodynia 60.39 12.91 10 46105 221994 110321190
Therapeutic product effect decreased 60.18 12.91 14 46101 244302 110298882
Hand fracture 59.70 12.91 39 46076 8083 110535101
Myalgia 59.54 12.91 216 45899 222165 110321019
Nervousness 59.30 12.91 75 46040 36776 110506408
Wheezing 58.33 12.91 17 46098 255213 110287971
Death 58.05 12.91 493 45622 698376 109844808
Lower respiratory tract infection 55.91 12.91 16 46099 243090 110300094
Type 2 diabetes mellitus 55.49 12.91 5 46110 177227 110365957
Gait disturbance 55.10 12.91 246 45869 277962 110265222
Breast cancer 53.59 12.91 73 46042 38469 110504715
Drug abuse 52.96 12.91 6 46109 177405 110365779
Malignant neoplasm progression 51.87 12.91 6 46109 174561 110368623
Exposure during pregnancy 51.68 12.91 5 46110 167419 110375765
Stress fracture 51.44 12.91 34 46081 7187 110535997
Drug hypersensitivity 48.86 12.91 71 46044 454019 110089165
Urine calcium increased 48.46 12.91 11 46104 108 110543076
Blood parathyroid hormone increased 48.33 12.91 27 46088 4221 110538963
Headache 48.33 12.91 571 45544 881806 109661378
Systemic lupus erythematosus 47.98 12.91 23 46092 254315 110288869
Musculoskeletal discomfort 47.91 12.91 54 46061 23484 110519700
Liver injury 47.75 12.91 4 46111 150409 110392775
Wound 47.70 12.91 19 46096 234418 110308766
Osteoporotic fracture 47.69 12.91 29 46086 5308 110537876
Intentional product use issue 47.41 12.91 22 46093 247884 110295300
Post procedural complication 47.31 12.91 57 46058 26601 110516583
Product use issue 46.58 12.91 37 46078 311658 110231526
Fracture nonunion 46.08 12.91 19 46096 1515 110541669
Balance disorder 45.59 12.91 129 45986 116431 110426753
Ankle fracture 44.73 12.91 48 46067 19771 110523413
Patella fracture 43.71 12.91 21 46094 2405 110540779
Blood calcium abnormal 43.47 12.91 19 46096 1750 110541434
Multiple fractures 42.70 12.91 33 46082 8907 110534277
Bone fissure 42.28 12.91 14 46101 600 110542584
Radius fracture 41.67 12.91 24 46091 3976 110539208
Injection site rash 41.44 12.91 50 46065 23369 110519815
Cervical vertebral fracture 41.09 12.91 25 46090 4580 110538604
Cardiac disorder 39.71 12.91 94 46021 76186 110466998
Ulna fracture 39.21 12.91 16 46099 1242 110541942
Recalled product 38.45 12.91 15 46100 1035 110542149
Osteonecrosis 38.24 12.91 58 46057 33683 110509501
Contusion 37.96 12.91 195 45920 233166 110310018
Obesity 36.02 12.91 3 46112 113348 110429836
Intentional overdose 35.96 12.91 6 46109 132495 110410689
Fractured sacrum 34.80 12.91 17 46098 2019 110541165
General physical health deterioration 34.57 12.91 79 46036 425216 110117968
Complication associated with device 34.13 12.91 42 46073 20031 110523153
Blister 33.95 12.91 27 46088 227349 110315835
Leukopenia 33.82 12.91 10 46105 148781 110394403
Breast cancer in situ 33.13 12.91 14 46101 1187 110541997
Fibromyalgia 32.93 12.91 15 46100 170894 110372290
Diarrhoea 32.64 12.91 311 45804 1139194 109403990
Fear 32.35 12.91 44 46071 23149 110520035
Injury associated with device 32.08 12.91 21 46094 4368 110538816
Neutrophil count decreased 31.68 12.91 6 46109 120935 110422249
Bone scan abnormal 30.91 12.91 9 46106 250 110542934
Lip dry 30.85 12.91 3 46112 100080 110443104
Irritable bowel syndrome 30.73 12.91 15 46100 164200 110378984
Sleep disorder due to general medical condition, insomnia type 30.47 12.91 4 46111 105639 110437545
Arrhythmia 30.19 12.91 80 46035 69495 110473689
Osteocalcin increased 29.98 12.91 5 46110 6 110543178
Myocardial infarction 29.50 12.91 158 45957 191925 110351259
Head injury 29.20 12.91 59 46056 42958 110500226
Neck pain 29.12 12.91 115 46000 123015 110420169
Vertigo 29.08 12.91 91 46024 86779 110456405
Device failure 28.88 12.91 24 46091 7183 110536001
C-reactive protein increased 28.79 12.91 29 46086 217890 110325294
Pancytopenia 28.73 12.91 27 46088 209586 110333598
Atypical fracture 28.15 12.91 12 46103 1040 110542144
Intestinal obstruction 28.14 12.91 66 46049 53161 110490023
Hypercalciuria 27.67 12.91 10 46105 558 110542626
Injection site irritation 27.58 12.91 20 46095 4904 110538280
White blood cell count decreased 27.58 12.91 33 46082 229357 110313827
Suicide attempt 27.36 12.91 5 46110 103389 110439795
Therapeutic response decreased 27.02 12.91 4 46111 96495 110446689
Calcinosis 26.78 12.91 16 46099 2836 110540348
Pain in jaw 26.56 12.91 63 46052 51114 110492070
Bradycardia 26.48 12.91 16 46099 155501 110387683
Liver function test increased 26.41 12.91 3 46112 88545 110454639
Hallucination, synaesthetic 26.34 12.91 6 46109 60 110543124
Dementia Alzheimer's type 26.20 12.91 11 46104 918 110542266
Platelet count decreased 25.79 12.91 35 46080 230408 110312776
Colon cancer 25.72 12.91 33 46082 16410 110526774
Anaphylactic reaction 25.40 12.91 8 46107 114292 110428892
Injury 25.29 12.91 22 46093 177243 110365941
Loss of consciousness 25.24 12.91 154 45961 196152 110347032
Cementoplasty 24.89 12.91 4 46111 3 110543181
Osteonecrosis of jaw 24.80 12.91 59 46056 47958 110495226
Dystrophic calcification 24.71 12.91 7 46108 176 110543008
Fatigue 24.62 12.91 672 45443 1215286 109327898
Oedema 24.41 12.91 31 46084 209945 110333239
Delirium 24.27 12.91 13 46102 135012 110408172
Injection site discolouration 24.06 12.91 24 46091 9079 110534105
Plasma cell myeloma 23.96 12.91 69 46046 62867 110480317
Musculoskeletal chest pain 23.82 12.91 43 46072 28804 110514380
Parkinson's disease 23.79 12.91 12 46103 1527 110541657
Calcium ionised increased 23.70 12.91 8 46107 364 110542820
Gammopathy 23.37 12.91 7 46108 215 110542969
Grip strength decreased 23.21 12.91 3 46112 80171 110463013
Drug ineffective for unapproved indication 23.21 12.91 7 46108 102831 110440353
Vitamin D decreased 23.13 12.91 27 46088 12188 110530996
Growing pains 23.06 12.91 5 46110 39 110543145
Tremor 22.52 12.91 153 45962 202079 110341105
Urinary bladder polyp 22.47 12.91 7 46108 246 110542938
Peripheral venous disease 22.40 12.91 4 46111 84113 110459071
Neuropathy peripheral 22.40 12.91 25 46090 179252 110363932
Sternal fracture 22.14 12.91 15 46100 3301 110539883
Laryngeal pain 22.09 12.91 19 46096 5956 110537228
Blood calcium decreased 21.80 12.91 47 46068 35798 110507386
Neoplasm malignant 21.79 12.91 48 46067 37095 110506089
Weight decreased 21.73 12.91 294 45821 467763 110075421
Injection site urticaria 21.53 12.91 31 46084 17184 110526000
Multiple organ dysfunction syndrome 21.43 12.91 19 46096 151691 110391493
Groin pain 21.11 12.91 29 46086 15399 110527785
Hypotension 21.06 12.91 130 45985 523719 110019465
Bone cancer 20.99 12.91 13 46102 2457 110540727
Dysstasia 20.93 12.91 44 46071 32942 110510242
Hernia repair 20.68 12.91 13 46102 2523 110540661
Metabolic acidosis 20.42 12.91 8 46107 99736 110443448
Pollakiuria 20.38 12.91 52 46063 44143 110499041
Sinusitis 20.34 12.91 60 46055 296628 110246556
Hyperparathyroidism 20.27 12.91 15 46100 3795 110539389
Leukaemia 20.20 12.91 20 46095 7498 110535686
Face injury 20.20 12.91 16 46099 4476 110538708
Lung neoplasm malignant 20.16 12.91 44 46071 33798 110509386
Jaw disorder 20.14 12.91 17 46098 5195 110537989
Fibula fracture 19.87 12.91 16 46099 4582 110538602
Clavicle fracture 19.66 12.91 17 46098 5367 110537817
Transient ischaemic attack 19.58 12.91 65 46050 63917 110479267
Vein disorder 19.34 12.91 18 46097 6252 110536932
Intentional dose omission 19.28 12.91 32 46083 20048 110523136
Cardiac pacemaker insertion 19.27 12.91 18 46097 6283 110536901
Psoriasis 19.22 12.91 18 46097 139975 110403209
Breast calcifications 19.15 12.91 9 46106 981 110542203
Spinal disorder 19.07 12.91 24 46091 11704 110531480
Intervertebral disc compression 19.01 12.91 10 46105 1387 110541797
Constipation 18.82 12.91 230 45885 357556 110185628
Bronchitis 18.81 12.91 121 45994 156911 110386273
Hepatitis 18.80 12.91 7 46108 90047 110453137
Incorrect product administration duration 18.80 12.91 32 46083 20466 110522718
Limb discomfort 18.77 12.91 48 46067 40806 110502378
Agitation 18.74 12.91 12 46103 113039 110430145
Liver disorder 18.70 12.91 19 46096 142224 110400960
Bursitis 18.68 12.91 16 46099 129902 110413282
Extrasystoles 18.51 12.91 20 46095 8298 110534886
Manufacturing product shipping issue 18.41 12.91 5 46110 107 110543077
Muscle disorder 18.39 12.91 18 46097 6654 110536530
Rhabdomyolysis 18.34 12.91 14 46101 120387 110422797
Discomfort 18.15 12.91 39 46076 214668 110328516
Urinary tract infection 18.14 12.91 212 45903 326070 110217114
Skeletal injury 18.13 12.91 10 46105 1525 110541659
Hyperkalaemia 18.01 12.91 18 46097 135778 110407406
Kyphosis 17.98 12.91 13 46102 3174 110540010
Periprosthetic fracture 17.98 12.91 8 46107 769 110542415
Enchondromatosis 17.95 12.91 5 46110 118 110543066
Rash 17.94 12.91 238 45877 820726 109722458
Breast cancer female 17.91 12.91 24 46091 12444 110530740
Extraskeletal ossification 17.79 12.91 5 46110 122 110543062
Wound infection 17.76 12.91 9 46106 96456 110446728
Taste disorder 17.65 12.91 3 46112 65384 110477800
Joint range of motion decreased 17.52 12.91 15 46100 121817 110421367
Open fracture 17.44 12.91 7 46108 521 110542663
N-telopeptide urine increased 17.29 12.91 4 46111 43 110543141
Exostosis of jaw 17.26 12.91 9 46106 1226 110541958
Breast enlargement 17.24 12.91 10 46105 1679 110541505
Visual acuity reduced 17.12 12.91 40 46075 32133 110511051
Fractured coccyx 17.11 12.91 9 46106 1249 110541935
Hip surgery 17.06 12.91 14 46101 4116 110539068
Wrong product stored 17.06 12.91 3 46112 6 110543178
Emphysema 17.02 12.91 30 46085 19726 110523458
Pseudarthrosis 16.91 12.91 6 46109 317 110542867
Nerve compression 16.87 12.91 22 46093 11115 110532069
Facial bones fracture 16.76 12.91 15 46100 4956 110538228
Cardiac flutter 16.75 12.91 16 46099 5741 110537443
Hot flush 16.69 12.91 63 46052 65973 110477211
Procedural complication 16.62 12.91 19 46096 8386 110534798
Tetany 16.55 12.91 13 46102 3591 110539593
Heart rate irregular 16.51 12.91 41 46074 34233 110508951
Medication error 16.39 12.91 87 46028 105279 110437905
Hypersensitivity 16.36 12.91 100 46015 403898 110139286
Wrong technique in product usage process 16.34 12.91 76 46039 87272 110455912
Agranulocytosis 16.31 12.91 3 46112 61757 110481427
Posture abnormal 16.18 12.91 14 46101 4424 110538760
Wrong technique in device usage process 16.08 12.91 17 46098 6884 110536300
Sleep disorder 16.04 12.91 37 46078 198607 110344577
Femoral hernia 15.95 12.91 3 46112 10 110543174
Depressed level of consciousness 15.93 12.91 14 46101 112264 110430920
Skin laceration 15.86 12.91 40 46075 33713 110509471
Oestrogen receptor assay positive 15.86 12.91 6 46109 381 110542803
Peripheral swelling 15.85 12.91 101 46014 403933 110139251
Cholecystectomy 15.83 12.91 21 46094 10788 110532396
Accident 15.61 12.91 21 46094 10931 110532253
Angioedema 15.59 12.91 11 46104 98489 110444695
Prescribed underdose 15.52 12.91 4 46111 65170 110478014
Tooth loss 15.51 12.91 18 46097 8078 110535106
Swelling 15.22 12.91 85 46030 350956 110192228
Gastric disorder 15.13 12.91 39 46076 33318 110509866
Incorrect route of product administration 15.12 12.91 4 46111 64057 110479127
Device operational issue 15.11 12.91 8 46107 1124 110542060
Limb injury 15.05 12.91 42 46073 37594 110505590
Sjogren's syndrome 15.03 12.91 7 46108 748 110542436
Condition aggravated 14.63 12.91 217 45898 734619 109808565
Colitis ulcerative 14.57 12.91 7 46108 77356 110465828
Joint injury 14.41 12.91 43 46072 39951 110503233
Spinal deformity 14.40 12.91 8 46107 1237 110541947
Prosthesis implantation 14.38 12.91 4 46111 94 110543090
Encephalopathy 14.28 12.91 8 46107 81047 110462137
Basosquamous carcinoma of skin 14.25 12.91 3 46112 20 110543164
Renal disorder 14.02 12.91 49 46066 49430 110493754
Spondylolisthesis 13.89 12.91 12 46103 3786 110539398
Kidney infection 13.81 12.91 32 46083 25567 110517617
Abdominal pain 13.79 12.91 142 45973 512847 110030337
Ilium fracture 13.75 12.91 5 46110 284 110542900
Jaw fracture 13.67 12.91 11 46104 3145 110540039
Bone density abnormal 13.60 12.91 12 46103 3891 110539293
Sedation 13.60 12.91 6 46109 69677 110473507
Cardio-respiratory arrest 13.56 12.91 17 46098 115819 110427365
Rash maculo-papular 13.55 12.91 7 46108 74215 110468969
Burning sensation 13.52 12.91 61 46054 69151 110474033
Lumbar spinal stenosis 13.50 12.91 15 46100 6418 110536766
Infection 13.47 12.91 92 46023 362108 110181076
Serotonin syndrome 13.39 12.91 4 46111 59149 110484035
Ligament sprain 13.33 12.91 24 46091 16044 110527140
Primary biliary cholangitis 13.32 12.91 8 46107 1431 110541753
Anaemia 13.28 12.91 155 45960 546931 109996253
Bone callus excessive 12.99 12.91 3 46112 32 110543152
Suicidal ideation 12.98 12.91 12 46103 93925 110449259
Thrombophlebitis 12.94 12.91 16 46099 7663 110535521

FDA Adverse Event Reporting System (Pediatric)

None

Pharmacologic Action:

SourceCodeDescription
ATC H05AA02 SYSTEMIC HORMONAL PREPARATIONS, EXCL. SEX HORMONES AND INSULINS
CALCIUM HOMEOSTASIS
PARATHYROID HORMONES AND ANALOGUES
Parathyroid hormones and analogues
FDA CS M0015931 Parathyroid Hormone
FDA EPC N0000180852 Parathyroid Hormone Analog
MeSH PA D000077264 Calcium-Regulating Hormones and Agents
MeSH PA D050071 Bone Density Conservation Agents
CHEBI has role CHEBI:50646 bone density conservation agent
CHEBI has role CHEBI:50748 antipsoriatic

Related Drugs by ATC class:

H05AA Parathyroid hormones and analogues 3 drugs
abaloparatidepalopegteriparatideparathyroid hormone

Drug Use | Suggest Off label Use Form| |View source of the data|

DiseaseRelationSNOMED_IDDOID
Postmenopausal osteoporosis indication 102447009
Hypogonadal Osteoporosis in Males indication
Glucocorticoid Induced Osteoporosis indication
Osteitis deformans contraindication 2089002 DOID:5408
Osteomalacia contraindication 4598005 DOID:10573
Renal osteodystrophy contraindication 16726004 DOID:13068
Hepatic osteodystrophy contraindication 28193003
Rickets contraindication 41345002 DOID:10609
Low blood pressure contraindication 45007003
Metabolic bone disease contraindication 50279003
Hypercalcemia contraindication 66931009 DOID:12678
Hyperparathyroidism contraindication 66999008 DOID:13543
Osteitis fibrosa cystica generalisata contraindication 84727000 DOID:3341
Metastatic malignant neoplasm to bone contraindication 94222008
Urolithiasis contraindication 95566004
Renal impairment contraindication 236423003
Alkaline phosphatase raised contraindication 274770006
Pregnancy, function contraindication 289908002
Osteosarcoma of bone contraindication 307576001 DOID:3376
Breastfeeding (mother) contraindication 413712001
Malignant neoplasm of skeletal system contraindication 443679004
Radiation Therapy Involving Bone contraindication
Bone Metastases contraindication




🐶 Veterinary Drug Use

None

🐶 Veterinary products

None

Acid dissociation constants calculated using MoKa v3.0.0

Dissociation levelDissociation constantType (acidic/basic)
pKa1 3.23 acidic
pKa2 3.31 acidic
pKa3 3.82 acidic
pKa4 4.11 acidic
pKa5 4.44 acidic
pKa6 11.68 acidic
pKa7 12.17 acidic
pKa8 12.35 acidic
pKa9 12.6 acidic
pKa10 12.63 acidic
pKa11 12.75 acidic
pKa12 12.78 acidic
pKa13 12.93 acidic
pKa14 13.16 acidic
pKa15 13.18 acidic
pKa16 13.37 acidic
pKa17 13.37 acidic
pKa18 13.44 acidic
pKa19 13.47 acidic
pKa20 13.57 acidic
pKa21 13.72 acidic
pKa22 13.72 acidic
pKa23 13.74 acidic
pKa24 13.82 acidic
pKa25 13.89 acidic
pKa26 11.47 Basic
pKa27 11.08 Basic
pKa28 10.81 Basic
pKa29 10.48 Basic
pKa30 10.09 Basic
pKa31 7.63 Basic
pKa32 7.16 Basic
pKa33 6.69 Basic
pKa34 6.21 Basic

Orange Book patent data (new drug applications)

None

Orange Book exclusivity data (new drug applications)

None

Bioactivity Summary:

TargetClassPharosUniProtActionTypeActivity value
(-log[M])		Mechanism
action		Bioact sourceMoA source
Parathyroid hormone/parathyroid hormone-related peptide receptor GPCR AGONIST IC50 7.40 IUPHAR CHEMBL
Parathyroid hormone 2 receptor GPCR AGONIST IC50 7.80 IUPHAR
Parathyroid hormone 2 receptor GPCR AGONIST IC50 6.30 IUPHAR
Parathyroid hormone/parathyroid hormone-related peptide receptor GPCR AGONIST IC50 8.70 IUPHAR

External reference:

IDSource
D03358 KEGG_DRUG
4019512 VUID
N0000147632 NUI
4019512 VANDF
CHEMBL525610 ChEMBL_ID
CHEMBL1201549 ChEMBL_ID
4448 IUPHAR_LIGAND_ID
5411 INN_ID
99294-94-7 SECONDARY_CAS_RN
DB06285 DRUGBANK_ID
10T9CSU89I UNII
114260 RXNORM
17041 MMSL
336918 MMSL
d04828 MMSL
002142 NDDF
004944 NDDF
109198008 SNOMEDCT_US
398823001 SNOMEDCT_US
425438001 SNOMEDCT_US
C0070093 UMLSCUI
D019379 MESH_DESCRIPTOR_UI
CHEBI:135983 CHEBI
16133850 PUBCHEM_CID

Pharmaceutical products:

ProductCategoryIngredientsNDCFormQuantityRouteMarketingLabel
Forteo HUMAN PRESCRIPTION DRUG LABEL 1 0002-8400 INJECTION, SOLUTION 250 ug SUBCUTANEOUS NDA 34 sections
Forteo HUMAN PRESCRIPTION DRUG LABEL 1 0002-9678 INJECTION, SOLUTION 250 ug SUBCUTANEOUS NDA 34 sections
Teriparatide HUMAN PRESCRIPTION DRUG LABEL 1 0093-1106 INJECTION, SOLUTION 250 ug SUBCUTANEOUS ANDA 28 sections
Teriparatide HUMAN PRESCRIPTION DRUG LABEL 1 0548-2311 INJECTION 250 ug SUBCUTANEOUS ANDA 32 sections
teriparatide HUMAN PRESCRIPTION DRUG LABEL 1 47781-652 INJECTION, SOLUTION 250 ug SUBCUTANEOUS NDA 34 sections
Bonsity HUMAN PRESCRIPTION DRUG LABEL 1 47781-852 INJECTION, SOLUTION 250 ug SUBCUTANEOUS NDA 34 sections
Teriparatide HUMAN PRESCRIPTION DRUG LABEL 1 60505-6188 INJECTION, SOLUTION 250 ug SUBCUTANEOUS ANDA 29 sections
Teriparatide HUMAN PRESCRIPTION DRUG LABEL 1 66993-495 INJECTION, SOLUTION 250 ug SUBCUTANEOUS NDA authorized generic 34 sections
Teriparatide HUMAN PRESCRIPTION DRUG LABEL 1 66993-989 INJECTION, SOLUTION 250 ug SUBCUTANEOUS NDA authorized generic 34 sections
Teriparatide HUMAN PRESCRIPTION DRUG LABEL 1 68001-693 INJECTION 250 ug SUBCUTANEOUS ANDA 32 sections