teriparatide Indications/Contra | FAERs-F | FAERs-M | Orange Bk | BioActivity |

Stem definition	Drug id	CAS RN
peptides and glycopeptides	4514	52232-67-4

Description:

Molecule

Description

Molfile Inchi Smiles Synonyms: teriparatide recombinant human forsteo teriparatide teriparatide acetate hPTH 1-34 parathar

A polypeptide that consists of the 1-34 amino-acid fragment of human PARATHYROID HORMONE, the biologically active N-terminal region. The acetate form is given by intravenous infusion in the differential diagnosis of HYPOPARATHYROIDISM and PSEUDOHYPOPARATHYROIDISM. (Reynolds JEF(Ed): Martindale: The Extra Pharmacopoeia (electronic version). Micromedex, Inc, Englewood, CO, 1995) Molecular weight: 4117.77 Formula: C181H291N55O51S2 CLOGP: LIPINSKI: None HAC: 106 HDO: 60 TPSA: 1752.65 ALOGS: ROTB: 144

Drug dosage:

Dose	Unit	Route
20	mcg	P

ADMET properties:

Property	Value	Reference
Vd (Volume of distribution)	0.17 L/kg	Lombardo F, Berellini G, Obach RS
CL (Clearance)	21.40 mL/min/kg	Lombardo F, Berellini G, Obach RS
t_half (Half-life)	0.14 hours	Lombardo F, Berellini G, Obach RS

Approvals:

Date	Agency	Company	Orphan
July 23, 2019	PMDA	Eli Lilly Japan
June 10, 2003	EMA
Nov. 26, 2002	FDA	LILLY

FDA Adverse Event Reporting System (Female)

MedDRA adverse event term	Likelihood ratio	Likelihood ratio threshold	Patients taking drug having adverse event	Patients taking drug not having adverse event	Patients not taking drug having adverse event	Patients not taking drug not having adverse event
Fall	1318.49	13.14	1900	64361	356540	52926265
Product complaint	1193.31	13.14	480	65781	11777	53271028
Blood calcium increased	936.63	13.14	361	65900	7875	53274930
Hip fracture	747.24	13.14	455	65806	27802	53255003
Bone pain	697.86	13.14	546	65715	50176	53232629
Muscle spasms	516.26	13.14	731	65530	134064	53148741
Injection site haemorrhage	477.50	13.14	313	65948	21738	53261067
Therapy cessation	472.69	13.14	341	65920	27684	53255121
Hospitalisation	456.99	13.14	500	65761	70512	53212293
Drug ineffective	436.45	13.14	238	66023	817007	52465798
Spinal fracture	434.47	13.14	265	65996	16220	53266585
Product storage error	416.67	13.14	238	66023	12892	53269913
Dizziness	405.22	13.14	1194	65067	371065	52911740
Femur fracture	351.87	13.14	332	65929	39253	53243552
Pelvic fracture	326.40	13.14	199	66062	12165	53270640
Hypercalcaemia	321.44	13.14	256	66005	24092	53258713
Pain in extremity	284.78	13.14	888	65373	284162	52998643
Injection site erythema	276.36	13.14	406	65855	76843	53205962
Fracture	271.67	13.14	205	66056	17814	53264991
Wrist fracture	270.23	13.14	176	66085	12079	53270726
Injection site bruising	241.83	13.14	265	65996	37381	53245424
Back pain	240.47	13.14	737	65524	233510	53049295
Bone density decreased	234.46	13.14	155	66106	10909	53271896
Toxicity to various agents	214.74	13.14	15	66246	219583	53063222
Rib fracture	209.28	13.14	185	66076	20093	53262712
Arthralgia	201.18	13.14	1075	65186	438708	52844097
Injection site haematoma	186.26	13.14	109	66152	6176	53276629
Off label use	177.94	13.14	195	66066	472017	52810788
Upper limb fracture	171.98	13.14	153	66108	16754	53266051
Drug intolerance	170.24	13.14	26	66235	205467	53077338
Injection site pain	168.43	13.14	409	65852	112982	53169823
Rheumatoid arthritis	164.85	13.14	93	66168	314438	52968367
Spinal operation	163.03	13.14	101	66160	6350	53276455
Feeling abnormal	155.03	13.14	443	65818	134858	53147947
Completed suicide	152.83	13.14	4	66257	138197	53144608
Acute kidney injury	151.34	13.14	63	66198	253805	53029000
Neutropenia	146.90	13.14	14	66247	159171	53123634
Infusion related reaction	143.17	13.14	14	66247	155943	53126862
Drug hypersensitivity	138.11	13.14	79	66182	265163	53017642
Lumbar vertebral fracture	133.70	13.14	81	66180	4891	53277914
Asthenia	133.09	13.14	804	65457	342786	52940019
Treatment failure	130.77	13.14	7	66254	128396	53154409
Nephrolithiasis	128.21	13.14	191	66070	36556	53246249
Femoral neck fracture	127.72	13.14	96	66165	8287	53274518
Product dose omission issue	125.80	13.14	521	65740	191099	53091706
Vertebroplasty	119.84	13.14	35	66226	307	53282498
Drug interaction	118.98	13.14	62	66199	219267	53063538
Febrile neutropenia	112.52	13.14	4	66257	104932	53177873
Spinal compression fracture	106.88	13.14	107	66154	13583	53269222
Chronic obstructive pulmonary disease	106.78	13.14	235	66026	60838	53221967
Bone disorder	106.56	13.14	130	66131	20553	53262252
Compression fracture	105.23	13.14	77	66184	6379	53276426
Pyrexia	104.61	13.14	215	66046	402978	52879827
Foot fracture	101.59	13.14	128	66133	20911	53261894
Therapeutic product effect decreased	101.52	13.14	17	66244	125638	53157167
Synovitis	95.62	13.14	11	66250	107882	53174923
Humerus fracture	92.40	13.14	79	66182	8200	53274605
Surgery	91.86	13.14	152	66109	31812	53250993
Thoracic vertebral fracture	89.24	13.14	60	66201	4341	53278464
Heart rate increased	87.93	13.14	263	65998	82052	53200753
Therapeutic product effect incomplete	87.55	13.14	7	66254	91777	53191028
Gait disturbance	86.81	13.14	409	65852	158433	53124372
Blood alkaline phosphatase increased	86.12	13.14	171	66090	41191	53241614
Thrombocytopenia	84.91	13.14	33	66228	138694	53144111
Glossodynia	82.28	13.14	13	66248	100278	53182527
Product use issue	80.92	13.14	36	66225	139548	53143257
Product use in unapproved indication	80.73	13.14	20	66241	112269	53170536
Disease progression	79.69	13.14	15	66246	101905	53180900
Hand deformity	79.48	13.14	7	66254	84842	53197963
Ankle fracture	77.40	13.14	99	66162	16416	53266389
Palpitations	77.33	13.14	291	65970	102057	53180748
Myalgia	76.07	13.14	348	65913	133143	53149662
Osteitis deformans	74.92	13.14	23	66238	243	53282562
Therapy interrupted	72.08	13.14	104	66157	19332	53263473
Medication error	71.72	13.14	147	66114	36218	53246587
Patella fracture	68.83	13.14	38	66223	1924	53280881
Systemic lupus erythematosus	68.62	13.14	35	66226	125379	53157426
Contusion	67.08	13.14	294	65967	110438	53172367
Malignant neoplasm progression	66.74	13.14	6	66255	71535	53211270
Tibia fracture	66.54	13.14	52	66209	4755	53278050
Cerebrovascular accident	65.81	13.14	282	65979	104892	53177913
Hand fracture	64.97	13.14	51	66210	4694	53278111
Lower limb fracture	64.76	13.14	84	66177	14121	53268684
Vitamin D decreased	64.08	13.14	66	66195	8663	53274142
Hepatic enzyme increased	63.59	13.14	39	66222	126156	53156649
White blood cell count decreased	63.38	13.14	38	66223	124437	53158368
Drug abuse	62.48	13.14	5	66256	65521	53217284
Diarrhoea	62.17	13.14	489	65772	625057	52657748
Intentional overdose	61.72	13.14	6	66255	67199	53215606
Recalled product	60.24	13.14	31	66230	1360	53281445
Psoriasis	59.77	13.14	17	66244	87072	53195733
Leukopenia	59.18	13.14	10	66251	73453	53209352
Stomatitis	58.98	13.14	24	66237	98134	53184671
Rash	58.86	13.14	320	65941	445871	52836934
Stress fracture	58.14	13.14	58	66203	7329	53275476
Pancytopenia	53.40	13.14	23	66238	90905	53191900
Condition aggravated	52.49	13.14	191	66070	296943	52985862
Platelet count decreased	52.28	13.14	35	66226	108064	53174741
Cardiac disorder	51.97	13.14	152	66109	46814	53235991
Lower respiratory tract infection	51.88	13.14	24	66237	90957	53191848
Hip arthroplasty	51.86	13.14	110	66151	27752	53255053
Wound	49.41	13.14	26	66235	91531	53191274
Fractured sacrum	47.74	13.14	30	66231	1933	53280872
Hip surgery	47.63	13.14	34	66227	2709	53280096
Pericarditis	47.21	13.14	11	66250	64395	53218410
Anaphylactic reaction	46.85	13.14	8	66253	58318	53224487
Balance disorder	46.32	13.14	197	66064	73010	53209795
Blood parathyroid hormone increased	46.02	13.14	35	66226	3074	53279731
Nausea	45.87	13.14	1245	65016	754846	52527959
Suicide attempt	44.53	13.14	9	66252	58159	53224646
Head injury	43.54	13.14	98	66163	25735	53257070
Neutrophil count decreased	43.50	13.14	5	66256	49093	53233712
Malaise	42.76	13.14	652	65609	356965	52925840
Myocardial infarction	42.49	13.14	239	66022	99115	53183690
Breast cancer	42.05	13.14	146	66115	49212	53233593
Urine calcium increased	42.03	13.14	11	66250	61	53282744
Therapeutic response decreased	41.76	13.14	5	66256	47564	53235241
Calciphylaxis	41.75	13.14	32	66229	2843	53279962
Musculoskeletal discomfort	41.71	13.14	72	66189	15588	53267217
Swelling	41.36	13.14	112	66149	190993	53091812
Pain	41.23	13.14	988	65273	587410	52695395
Nervousness	40.68	13.14	105	66156	30073	53252732
Dyspnoea	40.59	13.14	500	65761	585732	52697073
Hypotension	40.57	13.14	170	66091	253906	53028899
Abdominal pain	40.38	13.14	172	66089	255731	53027074
Pathological fracture	40.26	13.14	51	66210	8373	53274432
Bradycardia	40.11	13.14	19	66242	71037	53211768
Cervical vertebral fracture	40.00	13.14	29	66232	2368	53280437
Intentional product use issue	39.99	13.14	20	66241	72474	53210331
Body height decreased	39.79	13.14	55	66206	9824	53272981
Arrhythmia	39.70	13.14	118	66143	36661	53246144
Bone fissure	39.63	13.14	13	66248	173	53282632
Fracture nonunion	39.62	13.14	29	66232	2403	53280402
Injection site rash	38.74	13.14	72	66189	16507	53266298
Neuropathy peripheral	38.26	13.14	43	66218	103144	53179661
Peripheral swelling	38.02	13.14	130	66131	205978	53076827
Lung neoplasm malignant	37.60	13.14	72	66189	16880	53265925
Device failure	37.32	13.14	42	66219	6093	53276712
Fear	37.31	13.14	71	66190	16570	53266235
Hypokalaemia	37.13	13.14	39	66222	96478	53186327
Ulna fracture	37.12	13.14	21	66240	1115	53281690
Alanine aminotransferase increased	37.07	13.14	38	66223	95057	53187748
Breast cancer in situ	36.88	13.14	23	66238	1462	53281343
Incorrect product administration duration	36.72	13.14	55	66206	10569	53272236
Osteoporosis	36.64	13.14	134	66127	46326	53236479
Road traffic accident	36.44	13.14	91	66170	25540	53257265
Radius fracture	36.24	13.14	32	66229	3467	53279338
Wheezing	36.01	13.14	18	66243	65257	53217548
Death	35.90	13.14	633	65628	356599	52926206
Accident	35.66	13.14	39	66222	5482	53277323
Fibula fracture	35.19	13.14	30	66231	3101	53279704
Sinusitis	34.83	13.14	101	66160	168463	53114342
Helicobacter infection	34.56	13.14	4	66257	39065	53243740
Hypersensitivity	34.21	13.14	140	66121	210525	53072280
N-telopeptide urine increased	34.15	13.14	6	66255	0	53282805
Osteocalcin increased	34.15	13.14	6	66255	0	53282805
Calcinosis	33.74	13.14	24	66237	1902	53280903
Transient ischaemic attack	33.37	13.14	109	66152	35616	53247189
Multiple fractures	33.30	13.14	41	66220	6540	53276265
Movement disorder	32.75	13.14	72	66189	18609	53264196
Duodenal ulcer perforation	32.68	13.14	3	66258	35180	53247625
Injury associated with device	32.50	13.14	29	66232	3186	53279619
Blood calcium abnormal	32.46	13.14	19	66242	1076	53281729
Haemoglobin decreased	32.38	13.14	77	66184	137230	53145575
Suicidal ideation	31.46	13.14	18	66243	60493	53222312
Weight decreased	31.44	13.14	437	65824	234511	53048294
Post procedural complication	31.25	13.14	66	66195	16600	53266205
Joint swelling	31.00	13.14	168	66093	234470	53048335
Agitation	29.68	13.14	18	66243	58608	53224197
Joint dislocation	29.33	13.14	54	66207	12291	53270514
Muscular weakness	29.11	13.14	220	66041	100772	53182033
Accidental underdose	28.96	13.14	15	66246	667	53282138
Back disorder	28.91	13.14	47	66214	9688	53273117
Neck pain	28.78	13.14	149	66112	59867	53222938
Hernial eventration	28.67	13.14	6	66255	9	53282796
Multiple sclerosis relapse	28.55	13.14	10	66251	44843	53237962
Atypical femur fracture	28.41	13.14	34	66227	5267	53277538
Vomiting	27.93	13.14	442	65819	496697	52786108
Metabolic acidosis	27.61	13.14	9	66252	42233	53240572
Loss of consciousness	27.60	13.14	239	66022	113973	53168832
Sternal fracture	27.47	13.14	21	66240	1858	53280947
Hyperparathyroidism	27.27	13.14	24	66237	2589	53280216
Clavicle fracture	27.24	13.14	26	66235	3112	53279693
Memory impairment	26.93	13.14	189	66072	84568	53198237
Bone marrow failure	26.84	13.14	3	66258	30112	53252693
Emphysema	26.80	13.14	46	66215	9913	53272892
Neoplasm progression	26.62	13.14	3	66258	29916	53252889
Folliculitis	26.25	13.14	4	66257	31705	53251100
Hypercalciuria	26.06	13.14	10	66251	215	53282590
Breast calcifications	25.85	13.14	17	66244	1185	53281620
Angioedema	25.74	13.14	10	66251	42066	53240739
Oxygen saturation decreased	25.27	13.14	35	66226	76690	53206115
Blood bilirubin increased	24.46	13.14	7	66254	35723	53247082
Bone scan abnormal	24.42	13.14	11	66250	358	53282447
Rhabdomyolysis	24.40	13.14	12	66249	43911	53238894
C-reactive protein increased	24.39	13.14	29	66232	67857	53214948
Hyperkalaemia	24.35	13.14	19	66242	54237	53228568
Facial bones fracture	24.34	13.14	26	66235	3558	53279247
Headache	23.90	13.14	852	65409	535969	52746836
Encephalopathy	23.78	13.14	8	66253	36800	53246005
Heart rate irregular	23.54	13.14	67	66194	20317	53262488
Dementia Alzheimer's type	23.51	13.14	16	66245	1181	53281624
Cardio-respiratory arrest	23.44	13.14	23	66238	58735	53224070
Pulmonary arterial hypertension	23.44	13.14	3	66258	27119	53255686
Enchondromatosis	23.33	13.14	7	66254	68	53282737
Aspartate aminotransferase increased	23.27	13.14	43	66218	83986	53198819
Nerve compression	23.22	13.14	37	66224	7499	53275306
Vein disorder	23.21	13.14	28	66233	4373	53278432
Breast cancer female	23.19	13.14	35	66226	6769	53276036
Spinal deformity	23.18	13.14	15	66246	1017	53281788
Prosthesis implantation	23.15	13.14	7	66254	70	53282735
Blister	22.98	13.14	39	66222	78714	53204091
Liver function test increased	22.88	13.14	3	66258	26625	53256180
Hyponatraemia	22.47	13.14	65	66196	108542	53174263
Addison's disease	22.23	13.14	7	66254	81	53282724
Drug withdrawal syndrome	22.16	13.14	4	66257	28018	53254787
Colon cancer	22.12	13.14	42	66219	9783	53273022
Ilium fracture	22.06	13.14	8	66253	146	53282659
Fluid overload	21.95	13.14	4	66257	27827	53254978
Cough	21.74	13.14	209	66052	256684	53026121
Abdominal discomfort	21.74	13.14	173	66088	220889	53061916
Groin pain	21.73	13.14	41	66220	9507	53273298
Hallucination, synaesthetic	21.61	13.14	6	66255	43	53282762
Calcium ionised increased	21.47	13.14	8	66253	158	53282647
Vertigo	21.43	13.14	131	66130	55950	53226855
Hepatic cancer	21.35	13.14	24	66237	3477	53279328
Drug eruption	21.15	13.14	3	66258	25091	53257714
Fracture malunion	20.98	13.14	8	66253	169	53282636
Hernia hiatus repair	20.92	13.14	6	66255	49	53282756
Bone cancer	20.65	13.14	15	66246	1228	53281577
Productive cough	20.63	13.14	24	66237	56705	53226100
Pleural effusion	20.61	13.14	50	66211	88529	53194276
Extraskeletal ossification	20.61	13.14	6	66255	52	53282753
Cementoplasty	20.53	13.14	4	66257	3	53282802
Transaminases increased	20.45	13.14	6	66255	30126	53252679
Limb discomfort	20.45	13.14	74	66187	25448	53257357
Serotonin syndrome	20.39	13.14	4	66257	26402	53256403
Dysstasia	20.35	13.14	61	66200	19038	53263767
Neoplasm malignant	20.32	13.14	74	66187	25527	53257278
Hepatocellular injury	20.30	13.14	6	66255	29980	53252825
Hypoacusis	20.25	13.14	68	66193	22531	53260274
Leukaemia	20.24	13.14	24	66237	3682	53279123
Muscle injury	20.07	13.14	6	66255	29760	53253045
Rash maculo-papular	20.05	13.14	6	66255	29743	53253062
Oedema	19.75	13.14	39	66222	74307	53208498
Injection site irritation	19.69	13.14	26	66235	4446	53278359
Gammopathy	19.65	13.14	7	66254	121	53282684
Product distribution issue	19.53	13.14	11	66250	579	53282226
Joint injury	19.36	13.14	66	66195	22034	53260771
Osteoporotic fracture	19.23	13.14	22	66239	3249	53279556
Hepatitis	19.22	13.14	9	66252	33885	53248920
Visual acuity reduced	18.70	13.14	66	66195	22419	53260386
Intestinal obstruction	18.68	13.14	78	66183	28663	53254142
Musculoskeletal chest pain	18.26	13.14	60	66201	19662	53263143
Sleep disorder due to a general medical condition	18.20	13.14	33	66228	7424	53275381
Blood creatinine increased	18.20	13.14	48	66213	82614	53200191
General physical health deterioration	17.89	13.14	108	66153	146834	53135971
Parkinson's disease	17.88	13.14	15	66246	1516	53281289
Influenza	17.79	13.14	189	66072	95190	53187615
Spinal disorder	17.67	13.14	36	66225	8828	53273977
Face injury	17.67	13.14	20	66241	2920	53279885
International normalised ratio increased	17.59	13.14	20	66241	47741	53235064
Injection site streaking	17.53	13.14	5	66256	40	53282765
Tetany	17.40	13.14	16	66245	1827	53280978
Cataract operation	17.29	13.14	24	66237	4304	53278501
Growing pains	17.24	13.14	4	66257	12	53282793
Septic shock	17.09	13.14	32	66229	62197	53220608
Mucinous breast carcinoma	17.08	13.14	3	66258	0	53282805
Wrong product stored	17.08	13.14	3	66258	0	53282805
Type 2 diabetes mellitus	17.07	13.14	9	66252	31661	53251144
Joint arthroplasty	17.05	13.14	17	66244	2147	53280658
Rehabilitation therapy	16.96	13.14	14	66247	1384	53281421
Gait inability	16.92	13.14	93	66168	38218	53244587
Upper respiratory tract infection	16.88	13.14	38	66223	69059	53213746
Anaemia	16.88	13.14	242	66019	276476	53006329
Liver function test abnormal	16.77	13.14	21	66240	48050	53234755
Pseudarthrosis	16.70	13.14	9	66252	434	53282371
Product quality issue	16.57	13.14	13	66248	37010	53245795
Cardiac pacemaker insertion	16.42	13.14	22	66239	3815	53278990
Injection site discolouration	16.39	13.14	31	66230	7199	53275606
Hallucination	16.32	13.14	26	66235	53812	53228993
Drug ineffective for unapproved indication	16.29	13.14	3	66258	20717	53262088
Cystitis	16.24	13.14	107	66154	46881	53235924
Scoliosis	16.22	13.14	30	66231	6852	53275953
Pulmonary embolism	16.19	13.14	80	66181	114362	53168443
Constipation	15.93	13.14	340	65921	198072	53084733
Posture abnormal	15.92	13.14	17	66244	2326	53280479
Coma	15.90	13.14	33	66228	61750	53221055
Knee arthroplasty	15.85	13.14	83	66178	33486	53249319
Spinal fusion surgery	15.70	13.14	22	66239	3979	53278826
Osteonecrosis	15.64	13.14	70	66191	26505	53256300
Parathyroid tumour benign	15.57	13.14	10	66251	669	53282136
Blood calcium decreased	15.53	13.14	57	66204	19737	53263068
Knee operation	15.41	13.14	25	66236	5143	53277662
Blood lactate dehydrogenase increased	15.41	13.14	4	66257	21777	53261028
Dyspnoea exertional	15.35	13.14	28	66233	54972	53227833
Ascites	15.34	13.14	16	66245	39719	53243086
Somnolence	15.24	13.14	134	66127	167600	53115205
Sedation	15.18	13.14	9	66252	29666	53253139
Lymphocyte count decreased	15.08	13.14	8	66253	28044	53254761
Intentional product misuse	15.02	13.14	109	66152	49283	53233522
Traumatic shock	15.00	13.14	3	66258	3	53282802
Basosquamous carcinoma of skin	15.00	13.14	3	66258	3	53282802
Dystrophic calcification	14.94	13.14	6	66255	146	53282659
Depressed level of consciousness	14.93	13.14	28	66233	54400	53228405
Inguinal hernia	14.84	13.14	15	66246	1925	53280880
Complication associated with device	14.80	13.14	49	66212	16116	53266689
Stevens-Johnson syndrome	14.77	13.14	6	66255	24576	53258229
Spinal stenosis	14.71	13.14	45	66216	14196	53268609
Psychotic disorder	14.58	13.14	6	66255	24379	53258426
Gastrointestinal haemorrhage	14.57	13.14	51	66210	80279	53202526
Jaw disorder	14.54	13.14	25	66236	5393	53277412
Wrong technique in device usage process	14.54	13.14	17	66244	2570	53280235
Hyperglycaemia	14.53	13.14	17	66244	40067	53242738
Cardiac flutter	14.34	13.14	20	66241	3602	53279203
Skeletal injury	14.30	13.14	12	66249	1214	53281591
Cholestasis	14.26	13.14	9	66252	28686	53254119
Infection	14.17	13.14	141	66120	172064	53110741
Urinary bladder polyp	14.17	13.14	5	66256	84	53282721
Acetabulum fracture	14.13	13.14	7	66254	283	53282522
Hepatic function abnormal	14.08	13.14	15	66246	36884	53245921
Extrasystoles	14.08	13.14	24	66237	5142	53277663
Mass	14.00	13.14	41	66220	12628	53270177
Neoplasm	13.98	13.14	27	66234	6369	53276436
Liver injury	13.94	13.14	5	66256	22098	53260707
Manufacturing product shipping issue	13.90	13.14	5	66256	89	53282716
Uterine operation	13.79	13.14	3	66258	6	53282799
N-telopeptide urine decreased	13.79	13.14	3	66258	6	53282799
Oestrogen receptor assay positive	13.75	13.14	8	66253	448	53282357
Pain in jaw	13.69	13.14	92	66169	40577	53242228
Cardiac arrest	13.52	13.14	65	66196	93602	53189203
Limb crushing injury	13.50	13.14	6	66255	189	53282616
Vascular injury	13.48	13.14	10	66251	846	53281959
Hiatus hernia	13.34	13.14	54	66207	19566	53263239
Femoral hernia	13.23	13.14	4	66257	40	53282765
Hypoglycaemia	13.19	13.14	34	66227	58979	53223826
Abdominal strangulated hernia	13.18	13.14	5	66256	104	53282701

FDA Adverse Event Reporting System (Male)

MedDRA adverse event term	Likelihood ratio	Likelihood ratio threshold	Patients taking drug having adverse event	Patients taking drug not having adverse event	Patients not taking drug having adverse event	Patients not taking drug not having adverse event
Hospitalisation	127.70	20.22	91	5987	48880	32458568
Hip fracture	120.78	20.22	54	6024	11821	32495627
Product complaint	112.79	20.22	42	6036	5761	32501687
Bone pain	88.00	20.22	52	6026	20292	32487156
Spinal fracture	87.48	20.22	37	6041	7079	32500369
Fall	86.45	20.22	141	5937	196060	32311388
Therapy cessation	66.81	20.22	40	6038	15973	32491475
Spinal operation	62.69	20.22	22	6056	2543	32504905
Bone density decreased	52.65	20.22	18	6060	1924	32505524
Back pain	46.28	20.22	78	6000	110975	32396473
Muscle spasms	45.89	20.22	61	6017	70357	32437091
Death	43.51	20.22	163	5915	382354	32125094
Arthralgia	42.78	20.22	89	5989	148359	32359089
Femur fracture	41.92	20.22	23	6055	7785	32499663
Thoracic vertebral fracture	41.05	20.22	14	6064	1485	32505963
Vertebroplasty	40.56	20.22	7	6071	35	32507413
Pain in extremity	38.67	20.22	75	6003	118826	32388622
Injection site pain	37.28	20.22	38	6040	33020	32474428
Blood calcium increased	35.71	20.22	16	6062	3509	32503939
Acute kidney injury	33.64	20.22	7	6071	293461	32213987
Injection site erythema	33.04	20.22	25	6053	14643	32492805
Injection site haemorrhage	32.21	20.22	20	6058	8508	32498940
Osteoporotic fracture	32.16	20.22	11	6067	1177	32506271
Chronic obstructive pulmonary disease	31.37	20.22	42	6036	48711	32458737
Atypical femur fracture	30.45	20.22	8	6070	345	32507103
Dizziness	30.38	20.22	97	5981	209521	32297927
Fracture	28.66	20.22	17	6061	6662	32500786
Pneumonia	28.30	20.22	136	5942	355116	32152332
Pain	26.44	20.22	86	5992	187470	32319978
Injection site bruising	26.19	20.22	17	6061	7803	32499645
Product storage error	25.02	20.22	16	6062	7162	32500286
Incorrect product administration duration	23.78	20.22	13	6065	4365	32503083
Upper limb fracture	23.45	20.22	13	6065	4485	32502963
Hypercalcaemia	23.45	20.22	20	6058	13874	32493574
Tibia fracture	22.60	20.22	9	6069	1475	32505973
Injection site haematoma	22.23	20.22	9	6069	1539	32505909
Nephrolithiasis	21.43	20.22	26	6052	27328	32480120
Hernia repair	20.82	20.22	8	6070	1192	32506256
Recalled product	20.45	20.22	6	6072	390	32507058
Accidental underdose	20.33	20.22	6	6072	398	32507050

Pharmacologic Action:

Source	Code	Description
ATC	H05AA02	SYSTEMIC HORMONAL PREPARATIONS, EXCL. SEX HORMONES AND INSULINS CALCIUM HOMEOSTASIS PARATHYROID HORMONES AND ANALOGUES Parathyroid hormones and analogues
FDA CS	M0015931	Parathyroid Hormone
FDA EPC	N0000180852	Parathyroid Hormone Analog
MeSH PA	D050071	Bone Density Conservation Agents
MeSH PA	D000077264	Calcium-Regulating Hormones and Agents

Drug Use (View source of the data)

Disease	Relation	SNOMED_ID	DOID
Postmenopausal osteoporosis	indication	102447009
Glucocorticoid Induced Osteoporosis	indication
Hypogonadal Osteoporosis in Males	indication
Osteitis deformans	contraindication	2089002	DOID:5408
Osteomalacia	contraindication	4598005	DOID:10573
Renal osteodystrophy	contraindication	16726004	DOID:13068
Hepatic osteodystrophy	contraindication	28193003
Rickets	contraindication	41345002	DOID:10609
Low blood pressure	contraindication	45007003
Hypercalcemia	contraindication	66931009	DOID:12678
Osteitis fibrosa cystica generalisata	contraindication	84727000	DOID:3341
Urolithiasis	contraindication	95566004
Osteosarcoma of bone	contraindication	307576001	DOID:3376
Breastfeeding (mother)	contraindication	413712001
Bone Metastases	contraindication
Malignant Bone Disease	contraindication
Radiation Therapy Involving Bone	contraindication

Acid dissociation constants calculated using MoKa v3.0.0

Dissociation level	Dissociation constant	Type (acidic/basic)
pKa1	3.23	acidic
pKa2	3.31	acidic
pKa3	3.82	acidic
pKa4	4.11	acidic
pKa5	4.44	acidic
pKa6	11.68	acidic
pKa7	12.17	acidic
pKa8	12.35	acidic
pKa9	12.6	acidic
pKa10	12.63	acidic
pKa11	12.75	acidic
pKa12	12.78	acidic
pKa13	12.93	acidic
pKa14	13.16	acidic
pKa15	13.18	acidic
pKa16	13.37	acidic
pKa17	13.37	acidic
pKa18	13.44	acidic
pKa19	13.47	acidic
pKa20	13.57	acidic
pKa21	13.72	acidic
pKa22	13.72	acidic
pKa23	13.74	acidic
pKa24	13.82	acidic
pKa25	13.89	acidic
pKa26	11.47	Basic
pKa27	11.08	Basic
pKa28	10.81	Basic
pKa29	10.48	Basic
pKa30	10.09	Basic
pKa31	7.63	Basic
pKa32	7.16	Basic
pKa33	6.69	Basic
pKa34	6.21	Basic

Orange Book patent data (new drug applications)

None

Orange Book exclusivity data (new drug applications)

None

Bioactivity Summary:

Target	Class	Pharos	UniProt	Action	Type	Activity value (-log[M])	Mechanism action	Bioact source	MoA source
Parathyroid hormone/parathyroid hormone-related peptide receptor	GPCR	Q03431	PTH1R_HUMAN	AGONIST	IC50	7.40		IUPHAR	CHEMBL
Parathyroid hormone 2 receptor	GPCR	P49190	PTH2R_HUMAN	AGONIST	IC50	7.80		IUPHAR
Parathyroid hormone 2 receptor	GPCR		PTH2R_RAT	AGONIST	IC50	6.30		IUPHAR
Parathyroid hormone/parathyroid hormone-related peptide receptor	GPCR		PTH1R_RAT	AGONIST	IC50	8.70		IUPHAR

External reference:

ID	Source
D03358	KEGG_DRUG
4019512	VUID
N0000147632	NUI
99294-94-7	SECONDARY_CAS_RN
4019512	VANDF
CHEBI:135983	CHEBI
CHEMBL525610	ChEMBL_ID
CHEMBL1201549	ChEMBL_ID
4448	IUPHAR_LIGAND_ID
5411	INN_ID
DB06285	DRUGBANK_ID
10T9CSU89I	UNII
155817470	PUBCHEM_CID
114260	RXNORM
17041	MMSL
336918	MMSL
d04828	MMSL
002142	NDDF
004944	NDDF
109198008	SNOMEDCT_US
398823001	SNOMEDCT_US
425438001	SNOMEDCT_US
D019379	MESH_DESCRIPTOR_UI
C0070093	UMLSCUI

Pharmaceutical products:

Product	Category	Ingredients	NDC	Form	Quantity	Route	Marketing	Label
Forteo	HUMAN PRESCRIPTION DRUG LABEL	1	0002-8400	INJECTION, SOLUTION	250 ug	SUBCUTANEOUS	NDA	35 sections
teriparatide	HUMAN PRESCRIPTION DRUG LABEL	1	47781-652	INJECTION, SOLUTION	250 ug	SUBCUTANEOUS	NDA	30 sections