Stem definition | Drug id | CAS RN |
---|---|---|
peptides and glycopeptides | 4514 | 52232-67-4 |
Dose | Unit | Route |
---|---|---|
20 | mcg | P |
Property | Value | Reference |
---|---|---|
Vd (Volume of distribution) | 0.17 L/kg | Lombardo F, Berellini G, Obach RS |
CL (Clearance) | 21.40 mL/min/kg | Lombardo F, Berellini G, Obach RS |
t_half (Half-life) | 0.14 hours | Lombardo F, Berellini G, Obach RS |
Date | Agency | Company | Orphan |
---|---|---|---|
July 23, 2019 | PMDA | Eli Lilly Japan | |
June 10, 2003 | EMA | ||
Nov. 26, 2002 | FDA | LILLY |
MedDRA adverse event term | Likelihood ratio | Likelihood ratio threshold | Patients taking drug having adverse event | Patients taking drug not having adverse event | Patients not taking drug having adverse event | Patients not taking drug not having adverse event |
---|---|---|---|---|---|---|
Fall | 1369.87 | 13.47 | 1864 | 65160 | 390470 | 63031528 |
Product complaint | 1259.23 | 13.47 | 483 | 66541 | 12326 | 63409672 |
Blood calcium increased | 956.36 | 13.47 | 363 | 66661 | 8987 | 63413011 |
Hip fracture | 792.67 | 13.47 | 453 | 66571 | 29021 | 63392977 |
Bone pain | 761.05 | 13.47 | 555 | 66469 | 54086 | 63367912 |
Muscle spasms | 526.51 | 13.47 | 732 | 66292 | 155418 | 63266580 |
Therapy cessation | 520.90 | 13.47 | 351 | 66673 | 30106 | 63391892 |
Drug ineffective | 491.87 | 13.47 | 247 | 66777 | 1044518 | 62377480 |
Injection site haemorrhage | 491.08 | 13.47 | 311 | 66713 | 24003 | 63397995 |
Spinal fracture | 470.21 | 13.47 | 273 | 66751 | 17998 | 63404000 |
Hospitalisation | 456.40 | 13.47 | 504 | 66520 | 84577 | 63337421 |
Product storage error | 429.29 | 13.47 | 240 | 66784 | 14716 | 63407282 |
Dizziness | 428.74 | 13.47 | 1204 | 65820 | 428721 | 62993277 |
Femur fracture | 374.98 | 13.47 | 328 | 66696 | 41428 | 63380570 |
Pelvic fracture | 344.90 | 13.47 | 200 | 66824 | 13148 | 63408850 |
Hypercalcaemia | 326.16 | 13.47 | 257 | 66767 | 28065 | 63393933 |
Injection site erythema | 305.78 | 13.47 | 407 | 66617 | 82767 | 63339231 |
Fracture | 290.83 | 13.47 | 207 | 66817 | 19377 | 63402621 |
Pain in extremity | 288.22 | 13.47 | 885 | 66139 | 330601 | 63091397 |
Wrist fracture | 282.32 | 13.47 | 177 | 66847 | 13410 | 63408588 |
Back pain | 268.59 | 13.47 | 746 | 66278 | 263399 | 63158599 |
Injection site bruising | 262.98 | 13.47 | 270 | 66754 | 41640 | 63380358 |
Off label use | 257.49 | 13.47 | 202 | 66822 | 674260 | 62747738 |
Drug intolerance | 213.39 | 13.47 | 35 | 66989 | 308626 | 63113372 |
Rib fracture | 211.87 | 13.47 | 182 | 66842 | 22415 | 63399583 |
Bone density decreased | 211.32 | 13.47 | 152 | 66872 | 14460 | 63407538 |
Toxicity to various agents | 198.03 | 13.47 | 17 | 67007 | 247233 | 63174765 |
Injection site haematoma | 194.28 | 13.47 | 109 | 66915 | 6723 | 63415275 |
Infusion related reaction | 193.62 | 13.47 | 18 | 67006 | 245503 | 63176495 |
Upper limb fracture | 184.42 | 13.47 | 156 | 66868 | 18812 | 63403186 |
Feeling abnormal | 183.20 | 13.47 | 451 | 66573 | 147941 | 63274057 |
Injection site pain | 181.36 | 13.47 | 414 | 66610 | 129386 | 63292612 |
Treatment failure | 179.62 | 13.47 | 7 | 67017 | 199036 | 63222962 |
Spinal operation | 162.45 | 13.47 | 104 | 66920 | 8167 | 63413831 |
Asthenia | 159.82 | 13.47 | 813 | 66211 | 382791 | 63039207 |
Arthralgia | 155.99 | 13.47 | 1081 | 65943 | 568629 | 62853369 |
Synovitis | 154.83 | 13.47 | 11 | 67013 | 186907 | 63235091 |
Therapeutic product effect decreased | 142.51 | 13.47 | 18 | 67006 | 193169 | 63228829 |
Lumbar vertebral fracture | 142.01 | 13.47 | 84 | 66940 | 5726 | 63416272 |
Glossodynia | 141.28 | 13.47 | 13 | 67011 | 178863 | 63243135 |
Femoral neck fracture | 140.32 | 13.47 | 96 | 66928 | 8427 | 63413571 |
Hand deformity | 139.27 | 13.47 | 7 | 67017 | 159450 | 63262548 |
Chronic obstructive pulmonary disease | 138.19 | 13.47 | 242 | 66782 | 62444 | 63359554 |
Completed suicide | 135.35 | 13.47 | 4 | 67020 | 145669 | 63276329 |
Neutropenia | 134.85 | 13.47 | 14 | 67010 | 174991 | 63247007 |
Nephrolithiasis | 128.13 | 13.47 | 188 | 66836 | 41796 | 63380202 |
Product use issue | 128.03 | 13.47 | 37 | 66987 | 220483 | 63201515 |
Product dose omission issue | 126.47 | 13.47 | 536 | 66488 | 233777 | 63188221 |
Drug hypersensitivity | 125.97 | 13.47 | 87 | 66937 | 310600 | 63111398 |
Vertebroplasty | 124.27 | 13.47 | 35 | 66989 | 319 | 63421679 |
Spinal compression fracture | 119.78 | 13.47 | 108 | 66916 | 14175 | 63407823 |
Product use in unapproved indication | 117.81 | 13.47 | 23 | 67001 | 179057 | 63242941 |
Systemic lupus erythematosus | 117.75 | 13.47 | 37 | 66987 | 208881 | 63213117 |
Compression fracture | 116.63 | 13.47 | 77 | 66947 | 6371 | 63415627 |
Acute kidney injury | 116.06 | 13.47 | 67 | 66957 | 263348 | 63158650 |
Bone disorder | 115.32 | 13.47 | 127 | 66897 | 21199 | 63400799 |
Hepatic enzyme increased | 108.50 | 13.47 | 39 | 66985 | 202289 | 63219709 |
Surgery | 106.97 | 13.47 | 159 | 66865 | 35753 | 63386245 |
Foot fracture | 105.12 | 13.47 | 128 | 66896 | 23786 | 63398212 |
Febrile neutropenia | 104.06 | 13.47 | 5 | 67019 | 118444 | 63303554 |
Thoracic vertebral fracture | 103.45 | 13.47 | 63 | 66961 | 4529 | 63417469 |
Therapeutic product effect incomplete | 101.71 | 13.47 | 8 | 67016 | 125048 | 63296950 |
Pericarditis | 100.13 | 13.47 | 11 | 67013 | 131568 | 63290430 |
Blood alkaline phosphatase increased | 100.08 | 13.47 | 170 | 66854 | 42797 | 63379201 |
Pyrexia | 98.10 | 13.47 | 220 | 66804 | 470258 | 62951740 |
Wound | 97.34 | 13.47 | 26 | 66998 | 163237 | 63258761 |
Heart rate increased | 93.34 | 13.47 | 264 | 66760 | 93974 | 63328024 |
Humerus fracture | 92.19 | 13.47 | 76 | 66948 | 8840 | 63413158 |
Drug interaction | 91.71 | 13.47 | 65 | 66959 | 229066 | 63192932 |
Gait disturbance | 91.10 | 13.47 | 409 | 66615 | 182769 | 63239229 |
Therapy interrupted | 88.61 | 13.47 | 138 | 66886 | 32317 | 63389681 |
Palpitations | 87.47 | 13.47 | 290 | 66734 | 112480 | 63309518 |
Myalgia | 86.70 | 13.47 | 345 | 66679 | 146184 | 63275814 |
Ankle fracture | 84.10 | 13.47 | 99 | 66925 | 17756 | 63404242 |
Osteitis deformans | 81.53 | 13.47 | 23 | 67001 | 211 | 63421787 |
Helicobacter infection | 81.22 | 13.47 | 4 | 67020 | 92781 | 63329217 |
Disease progression | 80.22 | 13.47 | 16 | 67008 | 122742 | 63299256 |
Condition aggravated | 79.05 | 13.47 | 194 | 66830 | 402023 | 63019975 |
Duodenal ulcer perforation | 78.85 | 13.47 | 3 | 67021 | 87206 | 63334792 |
Stomatitis | 77.36 | 13.47 | 25 | 66999 | 138700 | 63283298 |
Cerebrovascular accident | 76.93 | 13.47 | 270 | 66754 | 107754 | 63314244 |
Rash | 75.74 | 13.47 | 320 | 66704 | 560551 | 62861447 |
Patella fracture | 73.92 | 13.47 | 39 | 66985 | 2127 | 63419871 |
Lower respiratory tract infection | 73.50 | 13.47 | 24 | 67000 | 132283 | 63289715 |
Intentional product use issue | 73.19 | 13.47 | 22 | 67002 | 127870 | 63294128 |
Thrombocytopenia | 73.12 | 13.47 | 34 | 66990 | 151123 | 63270875 |
Swelling | 72.12 | 13.47 | 112 | 66912 | 275266 | 63146732 |
Vitamin D decreased | 69.72 | 13.47 | 69 | 66955 | 10173 | 63411825 |
Rheumatoid arthritis | 67.64 | 13.47 | 102 | 66922 | 253717 | 63168281 |
Recalled product | 64.77 | 13.47 | 31 | 66993 | 1372 | 63420626 |
Malignant neoplasm progression | 64.72 | 13.47 | 6 | 67018 | 82115 | 63339883 |
Tibia fracture | 64.44 | 13.47 | 49 | 66975 | 5071 | 63416927 |
Nausea | 62.76 | 13.47 | 1256 | 65768 | 853215 | 62568783 |
Stress fracture | 62.45 | 13.47 | 58 | 66966 | 7905 | 63414093 |
Myocardial infarction | 61.32 | 13.47 | 238 | 66786 | 99655 | 63322343 |
Hand fracture | 60.45 | 13.47 | 49 | 66975 | 5564 | 63416434 |
Folliculitis | 58.59 | 13.47 | 4 | 67020 | 70313 | 63351685 |
Drug abuse | 57.95 | 13.47 | 5 | 67019 | 72513 | 63349485 |
White blood cell count decreased | 57.57 | 13.47 | 38 | 66986 | 139066 | 63282932 |
Intentional overdose | 56.91 | 13.47 | 6 | 67018 | 74146 | 63347852 |
Hypersensitivity | 56.79 | 13.47 | 142 | 66882 | 292543 | 63129455 |
Blood parathyroid hormone increased | 56.70 | 13.47 | 37 | 66987 | 3001 | 63418997 |
Death | 56.60 | 13.47 | 624 | 66400 | 373757 | 63048241 |
Cardiac disorder | 55.91 | 13.47 | 148 | 66876 | 50668 | 63371330 |
Breast cancer | 53.31 | 13.47 | 141 | 66883 | 48242 | 63373756 |
Head injury | 53.02 | 13.47 | 100 | 66924 | 27296 | 63394702 |
Pathological fracture | 51.94 | 13.47 | 55 | 66969 | 8779 | 63413219 |
Wheezing | 51.94 | 13.47 | 18 | 67006 | 95577 | 63326421 |
Medication error | 51.28 | 13.47 | 146 | 66878 | 52138 | 63369860 |
Body height decreased | 51.02 | 13.47 | 58 | 66966 | 10020 | 63411978 |
Balance disorder | 50.88 | 13.47 | 200 | 66824 | 84222 | 63337776 |
Leukopenia | 50.64 | 13.47 | 10 | 67014 | 77280 | 63344718 |
Joint swelling | 50.53 | 13.47 | 177 | 66847 | 327489 | 63094509 |
Fracture nonunion | 50.45 | 13.47 | 31 | 66993 | 2264 | 63419734 |
Nervousness | 50.22 | 13.47 | 105 | 66919 | 30874 | 63391124 |
Calciphylaxis | 49.15 | 13.47 | 34 | 66990 | 3038 | 63418960 |
Diarrhoea | 49.09 | 13.47 | 501 | 66523 | 714865 | 62707133 |
Muscle injury | 48.36 | 13.47 | 6 | 67018 | 65339 | 63356659 |
Contusion | 47.61 | 13.47 | 296 | 66728 | 149748 | 63272250 |
Fear | 47.22 | 13.47 | 70 | 66954 | 15696 | 63406302 |
Therapeutic response decreased | 47.16 | 13.47 | 5 | 67019 | 61520 | 63360478 |
Musculoskeletal discomfort | 47.10 | 13.47 | 75 | 66949 | 17892 | 63404106 |
Abdominal discomfort | 46.41 | 13.47 | 178 | 66846 | 320707 | 63101291 |
Fractured sacrum | 46.29 | 13.47 | 28 | 66996 | 1988 | 63420010 |
Liver injury | 46.18 | 13.47 | 5 | 67019 | 60515 | 63361483 |
Psoriasis | 46.17 | 13.47 | 17 | 67007 | 86940 | 63335058 |
Malaise | 45.58 | 13.47 | 653 | 66371 | 415301 | 63006697 |
Lower limb fracture | 45.13 | 13.47 | 87 | 66937 | 24134 | 63397864 |
Platelet count decreased | 45.04 | 13.47 | 34 | 66990 | 116088 | 63305910 |
Sinusitis | 44.70 | 13.47 | 109 | 66915 | 226544 | 63195454 |
Hip surgery | 44.41 | 13.47 | 33 | 66991 | 3298 | 63418700 |
Blister | 44.27 | 13.47 | 43 | 66981 | 129771 | 63292227 |
Cervical vertebral fracture | 44.14 | 13.47 | 30 | 66994 | 2604 | 63419394 |
Urine calcium increased | 43.95 | 13.47 | 11 | 67013 | 60 | 63421938 |
Discomfort | 43.85 | 13.47 | 68 | 66956 | 167306 | 63254692 |
Peripheral swelling | 43.48 | 13.47 | 140 | 66884 | 265802 | 63156196 |
Arrhythmia | 42.88 | 13.47 | 112 | 66912 | 38028 | 63383970 |
Bone fissure | 42.78 | 13.47 | 13 | 67011 | 158 | 63421840 |
Ulna fracture | 42.45 | 13.47 | 22 | 67002 | 1156 | 63420842 |
Neutrophil count decreased | 42.18 | 13.47 | 5 | 67019 | 56401 | 63365597 |
Pancytopenia | 42.14 | 13.47 | 25 | 66999 | 96908 | 63325090 |
Injection site rash | 41.92 | 13.47 | 73 | 66951 | 18736 | 63403262 |
Transient ischaemic attack | 40.56 | 13.47 | 109 | 66915 | 37644 | 63384354 |
Anaphylactic reaction | 40.38 | 13.47 | 10 | 67014 | 66090 | 63355908 |
Type 2 diabetes mellitus | 40.33 | 13.47 | 9 | 67015 | 63859 | 63358139 |
Breast cancer in situ | 40.02 | 13.47 | 23 | 67001 | 1485 | 63420513 |
Radius fracture | 39.71 | 13.47 | 32 | 66992 | 3603 | 63418395 |
Suicide attempt | 39.66 | 13.47 | 8 | 67016 | 60910 | 63361088 |
Lung neoplasm malignant | 39.66 | 13.47 | 73 | 66951 | 19560 | 63402438 |
Loss of consciousness | 39.34 | 13.47 | 236 | 66788 | 117885 | 63304113 |
Incorrect product administration duration | 38.58 | 13.47 | 54 | 66970 | 11492 | 63410506 |
Abdominal pain | 38.53 | 13.47 | 169 | 66855 | 293287 | 63128711 |
Post procedural complication | 37.70 | 13.47 | 66 | 66958 | 17008 | 63404990 |
Osteonecrosis | 37.29 | 13.47 | 81 | 66943 | 24449 | 63397549 |
Device failure | 36.37 | 13.47 | 38 | 66986 | 5973 | 63416025 |
Atypical femur fracture | 36.21 | 13.47 | 36 | 66988 | 5336 | 63416662 |
Multiple fractures | 36.05 | 13.47 | 45 | 66979 | 8573 | 63413425 |
Alopecia | 35.45 | 13.47 | 210 | 66814 | 337326 | 63084672 |
Blood calcium abnormal | 35.42 | 13.47 | 20 | 67004 | 1248 | 63420750 |
Arthropathy | 35.38 | 13.47 | 128 | 66896 | 234664 | 63187334 |
N-telopeptide urine increased | 35.13 | 13.47 | 6 | 67018 | 0 | 63421998 |
Osteocalcin increased | 35.13 | 13.47 | 6 | 67018 | 0 | 63421998 |
Calcinosis | 34.65 | 13.47 | 24 | 67000 | 2148 | 63419850 |
Fibula fracture | 34.15 | 13.47 | 29 | 66995 | 3513 | 63418485 |
Sleep disorder due to general medical condition, insomnia type | 33.70 | 13.47 | 7 | 67017 | 52210 | 63369788 |
Injury associated with device | 33.28 | 13.47 | 29 | 66995 | 3637 | 63418361 |
Neuropathy peripheral | 32.91 | 13.47 | 43 | 66981 | 113624 | 63308374 |
Weight decreased | 32.88 | 13.47 | 441 | 66583 | 276357 | 63145641 |
Accident | 32.74 | 13.47 | 36 | 66988 | 5996 | 63416002 |
Alanine aminotransferase increased | 32.43 | 13.47 | 37 | 66987 | 103733 | 63318265 |
Movement disorder | 32.33 | 13.47 | 71 | 66953 | 21590 | 63400408 |
General physical health deterioration | 32.23 | 13.47 | 107 | 66917 | 201295 | 63220703 |
Irritable bowel syndrome | 32.12 | 13.47 | 24 | 67000 | 82388 | 63339610 |
Hyperparathyroidism | 31.74 | 13.47 | 25 | 66999 | 2724 | 63419274 |
Bradycardia | 31.67 | 13.47 | 19 | 67005 | 73208 | 63348790 |
C-reactive protein increased | 31.56 | 13.47 | 32 | 66992 | 94675 | 63327323 |
Hypercalciuria | 31.11 | 13.47 | 12 | 67012 | 310 | 63421688 |
Neck pain | 30.88 | 13.47 | 150 | 66874 | 69168 | 63352830 |
Back disorder | 30.28 | 13.47 | 47 | 66977 | 10970 | 63411028 |
Dyspnoea | 30.20 | 13.47 | 504 | 66520 | 660809 | 62761189 |
Intestinal obstruction | 29.05 | 13.47 | 85 | 66939 | 30814 | 63391184 |
Clavicle fracture | 28.72 | 13.47 | 26 | 66998 | 3429 | 63418569 |
Heart rate irregular | 28.51 | 13.47 | 69 | 66955 | 22352 | 63399646 |
Fibromyalgia | 28.16 | 13.47 | 26 | 66998 | 80394 | 63341604 |
Emphysema | 27.77 | 13.47 | 45 | 66979 | 10893 | 63411105 |
Dementia Alzheimer's type | 27.68 | 13.47 | 16 | 67008 | 1044 | 63420954 |
Spinal deformity | 27.49 | 13.47 | 16 | 67008 | 1058 | 63420940 |
Breast calcifications | 27.42 | 13.47 | 17 | 67007 | 1261 | 63420737 |
Road traffic accident | 27.30 | 13.47 | 93 | 66931 | 36539 | 63385459 |
Memory impairment | 27.22 | 13.47 | 196 | 66828 | 104062 | 63317936 |
Colon cancer | 26.95 | 13.47 | 42 | 66982 | 9836 | 63412162 |
Muscular weakness | 26.92 | 13.47 | 221 | 66803 | 122132 | 63299866 |
Hypotension | 26.84 | 13.47 | 173 | 66851 | 272431 | 63149567 |
Visual acuity reduced | 26.51 | 13.47 | 66 | 66958 | 21760 | 63400238 |
Hypoacusis | 26.21 | 13.47 | 70 | 66954 | 24081 | 63397917 |
Oedema | 26.19 | 13.47 | 39 | 66985 | 97583 | 63324415 |
Accidental underdose | 26.11 | 13.47 | 14 | 67010 | 789 | 63421209 |
Facial bones fracture | 25.58 | 13.47 | 26 | 66998 | 3956 | 63418042 |
Vertigo | 25.54 | 13.47 | 128 | 66896 | 59759 | 63362239 |
Calcium ionised increased | 25.29 | 13.47 | 8 | 67016 | 112 | 63421886 |
Vein disorder | 25.03 | 13.47 | 29 | 66995 | 5112 | 63416886 |
Sternal fracture | 24.96 | 13.47 | 20 | 67004 | 2234 | 63419764 |
Pain | 24.91 | 13.47 | 986 | 66038 | 739642 | 62682356 |
Multiple sclerosis relapse | 24.86 | 13.47 | 10 | 67014 | 48468 | 63373530 |
Bone scan abnormal | 24.84 | 13.47 | 11 | 67013 | 406 | 63421592 |
Groin pain | 24.58 | 13.47 | 41 | 66983 | 10162 | 63411836 |
Suicidal ideation | 24.56 | 13.47 | 18 | 67006 | 62403 | 63359595 |
Hernial eventration | 24.50 | 13.47 | 5 | 67019 | 8 | 63421990 |
Angioedema | 24.43 | 13.47 | 10 | 67014 | 47955 | 63374043 |
Enchondromatosis | 24.18 | 13.47 | 7 | 67017 | 71 | 63421927 |
Plasma cell myeloma | 24.04 | 13.47 | 88 | 66936 | 35817 | 63386181 |
Illness | 23.76 | 13.47 | 11 | 67013 | 49048 | 63372950 |
Constipation | 23.72 | 13.47 | 351 | 66673 | 224592 | 63197406 |
Hypokalaemia | 23.68 | 13.47 | 46 | 66978 | 103758 | 63318240 |
Metabolic acidosis | 23.60 | 13.47 | 9 | 67015 | 45060 | 63376938 |
Cementoplasty | 23.42 | 13.47 | 4 | 67020 | 0 | 63421998 |
Ilium fracture | 23.38 | 13.47 | 8 | 67016 | 145 | 63421853 |
Hip arthroplasty | 23.34 | 13.47 | 106 | 66918 | 47540 | 63374458 |
Addison's disease | 23.27 | 13.47 | 7 | 67017 | 82 | 63421916 |
Osteoporotic fracture | 23.23 | 13.47 | 24 | 67000 | 3722 | 63418276 |
Drug ineffective for unapproved indication | 23.18 | 13.47 | 4 | 67020 | 34059 | 63387939 |
Headache | 23.16 | 13.47 | 851 | 66173 | 632390 | 62789608 |
Bone cancer | 23.16 | 13.47 | 16 | 67008 | 1426 | 63420572 |
Dysstasia | 22.62 | 13.47 | 61 | 66963 | 21105 | 63400893 |
Cardiac failure congestive | 22.55 | 13.47 | 171 | 66853 | 92262 | 63329736 |
Nerve compression | 22.54 | 13.47 | 37 | 66987 | 9050 | 63412948 |
Agitation | 22.53 | 13.47 | 18 | 67006 | 59739 | 63362259 |
Complication associated with device | 22.40 | 13.47 | 53 | 66971 | 16925 | 63405073 |
Haemoglobin decreased | 22.11 | 13.47 | 79 | 66945 | 145406 | 63276592 |
Liver function test increased | 22.01 | 13.47 | 4 | 67020 | 32807 | 63389191 |
Blood bilirubin increased | 21.95 | 13.47 | 6 | 67018 | 37134 | 63384864 |
Limb discomfort | 21.76 | 13.47 | 75 | 66949 | 29641 | 63392357 |
Influenza | 21.61 | 13.47 | 192 | 66832 | 108530 | 63313468 |
Vomiting | 21.59 | 13.47 | 439 | 66585 | 559178 | 62862820 |
Musculoskeletal stiffness | 21.46 | 13.47 | 111 | 66913 | 184507 | 63237491 |
Oxygen saturation decreased | 21.32 | 13.47 | 38 | 66986 | 88547 | 63333451 |
Spinal stenosis | 21.24 | 13.47 | 48 | 66976 | 14877 | 63407121 |
Hallucination, synaesthetic | 21.18 | 13.47 | 6 | 67018 | 56 | 63421942 |
Leukaemia | 20.93 | 13.47 | 24 | 67000 | 4184 | 63417814 |
Bone marrow failure | 20.93 | 13.47 | 3 | 67021 | 29287 | 63392711 |
Extraskeletal ossification | 20.88 | 13.47 | 7 | 67017 | 119 | 63421879 |
Injection site irritation | 20.83 | 13.47 | 26 | 66998 | 4952 | 63417046 |
Musculoskeletal chest pain | 20.79 | 13.47 | 59 | 66965 | 21024 | 63400974 |
Parkinson's disease | 20.70 | 13.47 | 14 | 67010 | 1205 | 63420793 |
Loss of personal independence in daily activities | 20.60 | 13.47 | 45 | 66979 | 97245 | 63324753 |
Infection | 20.29 | 13.47 | 150 | 66874 | 229023 | 63192975 |
Spinal disorder | 20.23 | 13.47 | 37 | 66987 | 9865 | 63412133 |
Hernia hiatus repair | 19.67 | 13.47 | 6 | 67018 | 74 | 63421924 |
Pneumonia | 19.47 | 13.47 | 625 | 66399 | 456142 | 62965856 |
Pain in jaw | 19.28 | 13.47 | 94 | 66930 | 43402 | 63378596 |
Tremor | 19.26 | 13.47 | 219 | 66805 | 132020 | 63289978 |
Prosthesis implantation | 19.17 | 13.47 | 6 | 67018 | 81 | 63421917 |
Hepatitis | 19.15 | 13.47 | 9 | 67015 | 39779 | 63382219 |
Gammopathy | 19.11 | 13.47 | 7 | 67017 | 156 | 63421842 |
Injection site streaking | 19.04 | 13.47 | 5 | 67019 | 34 | 63421964 |
Drug reaction with eosinophilia and systemic symptoms | 19.02 | 13.47 | 6 | 67018 | 33830 | 63388168 |
Neoplasm malignant | 19.00 | 13.47 | 72 | 66952 | 29789 | 63392209 |
Aspartate aminotransferase increased | 18.91 | 13.47 | 42 | 66982 | 90235 | 63331763 |
Fracture malunion | 18.67 | 13.47 | 7 | 67017 | 167 | 63421831 |
Face injury | 18.53 | 13.47 | 20 | 67004 | 3262 | 63418736 |
Tetany | 18.51 | 13.47 | 16 | 67008 | 1985 | 63420013 |
Sedation | 18.34 | 13.47 | 9 | 67015 | 38800 | 63383198 |
Posture abnormal | 18.31 | 13.47 | 17 | 67007 | 2315 | 63419683 |
Drug eruption | 18.20 | 13.47 | 4 | 67020 | 28690 | 63393308 |
Injection site discolouration | 18.20 | 13.47 | 31 | 66993 | 7817 | 63414181 |
Serotonin syndrome | 18.19 | 13.47 | 4 | 67020 | 28678 | 63393320 |
Hepatic cancer | 18.08 | 13.47 | 23 | 67001 | 4464 | 63417534 |
Skeletal injury | 18.06 | 13.47 | 13 | 67011 | 1237 | 63420761 |
Hypervolaemia | 17.94 | 13.47 | 4 | 67020 | 28409 | 63393589 |
Jaw disorder | 17.84 | 13.47 | 25 | 66999 | 5324 | 63416674 |
Cystitis | 17.74 | 13.47 | 109 | 66915 | 54882 | 63367116 |
Wrong product stored | 17.56 | 13.47 | 3 | 67021 | 0 | 63421998 |
Basosquamous carcinoma of skin | 17.56 | 13.47 | 3 | 67021 | 0 | 63421998 |
Obesity | 17.40 | 13.47 | 5 | 67019 | 29947 | 63392051 |
Growing pains | 17.20 | 13.47 | 4 | 67020 | 15 | 63421983 |
Angina pectoris | 17.10 | 13.47 | 70 | 66954 | 30008 | 63391990 |
Kyphosis | 17.08 | 13.47 | 17 | 67007 | 2523 | 63419475 |
Extrasystoles | 17.04 | 13.47 | 24 | 67000 | 5136 | 63416862 |
Cardio-respiratory arrest | 17.03 | 13.47 | 23 | 67001 | 59936 | 63362062 |
Joint dislocation | 16.99 | 13.47 | 51 | 66973 | 18749 | 63403249 |
Rehabilitation therapy | 16.92 | 13.47 | 14 | 67010 | 1636 | 63420362 |
Transaminases increased | 16.87 | 13.47 | 6 | 67018 | 31361 | 63390637 |
Rhabdomyolysis | 16.87 | 13.47 | 13 | 67011 | 43938 | 63378060 |
Drug withdrawal syndrome | 16.83 | 13.47 | 4 | 67020 | 27190 | 63394808 |
Dystrophic calcification | 16.63 | 13.47 | 6 | 67018 | 128 | 63421870 |
Cardiac flutter | 16.51 | 13.47 | 21 | 67003 | 4075 | 63417923 |
Urinary bladder polyp | 16.51 | 13.47 | 5 | 67019 | 60 | 63421938 |
Cardiac pacemaker insertion | 16.39 | 13.47 | 21 | 67003 | 4105 | 63417893 |
Gastrointestinal disorder | 16.35 | 13.47 | 77 | 66947 | 131162 | 63290836 |
Hyperkalaemia | 16.21 | 13.47 | 20 | 67004 | 54183 | 63367815 |
Therapy non-responder | 16.15 | 13.47 | 35 | 66989 | 75866 | 63346132 |
Nasopharyngitis | 16.15 | 13.47 | 181 | 66843 | 254076 | 63167922 |
Parathyroid tumour benign | 16.12 | 13.47 | 10 | 67014 | 743 | 63421255 |
Cough | 16.10 | 13.47 | 215 | 66809 | 292528 | 63129470 |
Joint arthroplasty | 16.00 | 13.47 | 17 | 67007 | 2724 | 63419274 |
Blood sodium decreased | 15.87 | 13.47 | 59 | 66965 | 24193 | 63397805 |
Renal stone removal | 15.74 | 13.47 | 6 | 67018 | 150 | 63421848 |
Neoplasm | 15.71 | 13.47 | 28 | 66996 | 7317 | 63414681 |
Rash maculo-papular | 15.68 | 13.47 | 7 | 67017 | 31889 | 63390109 |
Spondylolisthesis | 15.65 | 13.47 | 19 | 67005 | 3517 | 63418481 |
Mass | 15.62 | 13.47 | 41 | 66983 | 13959 | 63408039 |
Scoliosis | 15.52 | 13.47 | 29 | 66995 | 7859 | 63414139 |
Traumatic shock | 15.49 | 13.47 | 3 | 67021 | 3 | 63421995 |
Joint injury | 15.40 | 13.47 | 67 | 66957 | 29505 | 63392493 |
Wrong technique in device usage process | 15.39 | 13.47 | 19 | 67005 | 3579 | 63418419 |
Encephalopathy | 15.37 | 13.47 | 11 | 67013 | 38609 | 63383389 |
Productive cough | 15.31 | 13.47 | 27 | 66997 | 63181 | 63358817 |
Pseudarthrosis | 14.92 | 13.47 | 8 | 67016 | 451 | 63421547 |
Manufacturing product shipping issue | 14.86 | 13.47 | 5 | 67019 | 86 | 63421912 |
Ligament sprain | 14.81 | 13.47 | 38 | 66986 | 12762 | 63409236 |
Pulmonary arterial hypertension | 14.62 | 13.47 | 3 | 67021 | 22574 | 63399424 |
Injury | 14.60 | 13.47 | 35 | 66989 | 73212 | 63348786 |
Pleural effusion | 14.57 | 13.47 | 50 | 66974 | 93160 | 63328838 |
Inguinal hernia | 14.56 | 13.47 | 14 | 67010 | 1993 | 63420005 |
Product distribution issue | 14.49 | 13.47 | 12 | 67012 | 1404 | 63420594 |
Injection site urticaria | 14.48 | 13.47 | 40 | 66984 | 14033 | 63407965 |
Acetabulum fracture | 14.41 | 13.47 | 7 | 67017 | 320 | 63421678 |
Cataract operation | 14.40 | 13.47 | 23 | 67001 | 5499 | 63416499 |
Empyema | 14.31 | 13.47 | 14 | 67010 | 2035 | 63419963 |
N-telopeptide urine decreased | 14.27 | 13.47 | 3 | 67021 | 6 | 63421992 |
Knee operation | 14.27 | 13.47 | 24 | 67000 | 5989 | 63416009 |
Limb injury | 14.25 | 13.47 | 59 | 66965 | 25418 | 63396580 |
Upper respiratory tract infection | 14.23 | 13.47 | 42 | 66982 | 82005 | 63339993 |
Oestrogen receptor assay positive | 14.10 | 13.47 | 8 | 67016 | 504 | 63421494 |
Fracture delayed union | 14.10 | 13.47 | 15 | 67009 | 2407 | 63419591 |
Cystocele | 14.09 | 13.47 | 11 | 67013 | 1183 | 63420815 |
Spinal fusion surgery | 14.08 | 13.47 | 23 | 67001 | 5605 | 63416393 |
Osteoma | 13.87 | 13.47 | 4 | 67020 | 40 | 63421958 |
Bone graft | 13.80 | 13.47 | 10 | 67014 | 961 | 63421037 |
Depressed level of consciousness | 13.74 | 13.47 | 28 | 66996 | 62050 | 63359948 |
Psychotic disorder | 13.69 | 13.47 | 5 | 67019 | 25707 | 63396291 |
Arterial disorder | 13.56 | 13.47 | 11 | 67013 | 1250 | 63420748 |
Blood pressure decreased | 13.52 | 13.47 | 116 | 66908 | 64906 | 63357092 |
Laryngeal pain | 13.51 | 13.47 | 20 | 67004 | 4478 | 63417520 |
Hepatocellular injury | 13.48 | 13.47 | 6 | 67018 | 27375 | 63394623 |
MedDRA adverse event term | Likelihood ratio | Likelihood ratio threshold | Patients taking drug having adverse event | Patients taking drug not having adverse event | Patients not taking drug having adverse event | Patients not taking drug not having adverse event |
---|---|---|---|---|---|---|
Hip fracture | 137.03 | 20.90 | 58 | 6076 | 11867 | 34938930 |
Hospitalisation | 120.62 | 20.90 | 91 | 6043 | 56811 | 34893986 |
Product complaint | 114.77 | 20.90 | 42 | 6092 | 5848 | 34944949 |
Bone pain | 101.08 | 20.90 | 56 | 6078 | 20630 | 34930167 |
Fall | 89.59 | 20.90 | 141 | 5993 | 202744 | 34748053 |
Spinal fracture | 81.24 | 20.90 | 35 | 6099 | 7463 | 34943334 |
Therapy cessation | 69.61 | 20.90 | 41 | 6093 | 16932 | 34933865 |
Spinal operation | 61.09 | 20.90 | 22 | 6112 | 2922 | 34947875 |
Bone density decreased | 53.89 | 20.90 | 18 | 6116 | 1911 | 34948886 |
Death | 49.20 | 20.90 | 167 | 5967 | 397882 | 34552915 |
Muscle spasms | 45.90 | 20.90 | 61 | 6073 | 74940 | 34875857 |
Arthralgia | 45.21 | 20.90 | 95 | 6039 | 169946 | 34780851 |
Back pain | 43.32 | 20.90 | 77 | 6057 | 121712 | 34829085 |
Vertebroplasty | 42.69 | 20.90 | 7 | 6127 | 26 | 34950771 |
Pain in extremity | 39.97 | 20.90 | 76 | 6058 | 126437 | 34824360 |
Femur fracture | 39.66 | 20.90 | 22 | 6112 | 8102 | 34942695 |
Injection site pain | 37.55 | 20.90 | 40 | 6094 | 38965 | 34911832 |
Blood calcium increased | 36.39 | 20.90 | 16 | 6118 | 3578 | 34947219 |
Thoracic vertebral fracture | 36.16 | 20.90 | 13 | 6121 | 1717 | 34949080 |
Pneumonia | 32.92 | 20.90 | 138 | 5996 | 362489 | 34588308 |
Injection site erythema | 32.65 | 20.90 | 25 | 6109 | 15874 | 34934923 |
Acute kidney injury | 32.46 | 20.90 | 7 | 6127 | 304981 | 34645816 |
Dizziness | 31.65 | 20.90 | 97 | 6037 | 218424 | 34732373 |
Injection site haemorrhage | 30.88 | 20.90 | 20 | 6114 | 9748 | 34941049 |
Osteoporotic fracture | 29.72 | 20.90 | 10 | 6124 | 1085 | 34949712 |
Fracture | 29.26 | 20.90 | 17 | 6117 | 6832 | 34943965 |
Therapy interrupted | 29.15 | 20.90 | 22 | 6112 | 13675 | 34937122 |
Product storage error | 29.10 | 20.90 | 18 | 6116 | 8104 | 34942693 |
Pain | 27.91 | 20.90 | 89 | 6045 | 204586 | 34746211 |
Atypical femur fracture | 26.54 | 20.90 | 7 | 6127 | 327 | 34950470 |
Upper limb fracture | 26.30 | 20.90 | 14 | 6120 | 4752 | 34946045 |
Chronic obstructive pulmonary disease | 25.71 | 20.90 | 37 | 6097 | 48881 | 34901916 |
Injection site bruising | 25.59 | 20.90 | 17 | 6117 | 8646 | 34942151 |
Incorrect product administration duration | 23.40 | 20.90 | 13 | 6121 | 4798 | 34945999 |
Recalled product | 21.61 | 20.90 | 6 | 6128 | 341 | 34950456 |
Spinal compression fracture | 21.10 | 20.90 | 14 | 6120 | 7102 | 34943695 |
MedDRA adverse event term | Likelihood ratio | Likelihood ratio threshold | Patients taking drug having adverse event | Patients taking drug not having adverse event | Patients not taking drug having adverse event | Patients not taking drug not having adverse event |
---|---|---|---|---|---|---|
Product complaint | 1576.91 | 13.71 | 489 | 43125 | 12860 | 79687914 |
Fall | 798.98 | 13.71 | 1145 | 42469 | 486484 | 79214290 |
Blood calcium increased | 605.05 | 13.71 | 224 | 43390 | 10176 | 79690598 |
Bone pain | 509.14 | 13.71 | 339 | 43275 | 55403 | 79645371 |
Hip fracture | 436.71 | 13.71 | 248 | 43366 | 30513 | 79670261 |
Injection site haemorrhage | 423.64 | 13.71 | 235 | 43379 | 27635 | 79673139 |
Product storage error | 419.89 | 13.71 | 196 | 43418 | 16030 | 79684744 |
Spinal fracture | 405.95 | 13.71 | 198 | 43416 | 17856 | 79682918 |
Muscle spasms | 382.28 | 13.71 | 474 | 43140 | 174256 | 79526518 |
Therapy cessation | 334.57 | 13.71 | 225 | 43389 | 37337 | 79663437 |
Injection site erythema | 314.33 | 13.71 | 293 | 43321 | 77904 | 79622870 |
Dizziness | 296.18 | 13.71 | 788 | 42826 | 525653 | 79175121 |
Injection site bruising | 260.42 | 13.71 | 200 | 43414 | 40802 | 79659972 |
Femur fracture | 253.09 | 13.71 | 192 | 43422 | 38460 | 79662314 |
Hypercalcaemia | 236.52 | 13.71 | 184 | 43430 | 38246 | 79662528 |
Pain in extremity | 225.50 | 13.71 | 566 | 43048 | 363972 | 79336802 |
Wrist fracture | 224.59 | 13.71 | 116 | 43498 | 11805 | 79688969 |
Back pain | 224.55 | 13.71 | 506 | 43108 | 303674 | 79397100 |
Drug ineffective | 213.88 | 13.71 | 168 | 43446 | 1080745 | 78620029 |
Pelvic fracture | 199.45 | 13.71 | 108 | 43506 | 12096 | 79688678 |
Injection site pain | 188.20 | 13.71 | 289 | 43325 | 129549 | 79571225 |
Hospitalisation | 182.68 | 13.71 | 241 | 43373 | 93995 | 79606779 |
Toxicity to various agents | 177.87 | 13.71 | 14 | 43600 | 421526 | 79279248 |
Feeling abnormal | 171.30 | 13.71 | 310 | 43304 | 158889 | 79541885 |
Bone density decreased | 166.52 | 13.71 | 99 | 43515 | 13248 | 79687526 |
Arthralgia | 157.80 | 13.71 | 674 | 42940 | 571129 | 79129645 |
Spinal operation | 154.80 | 13.71 | 79 | 43535 | 7838 | 79692936 |
Acute kidney injury | 151.37 | 13.71 | 48 | 43566 | 519356 | 79181418 |
Upper limb fracture | 146.59 | 13.71 | 102 | 43512 | 17865 | 79682909 |
Therapy interrupted | 144.62 | 13.71 | 127 | 43487 | 31214 | 79669560 |
Off label use | 142.11 | 13.71 | 173 | 43441 | 907042 | 78793732 |
Fracture | 142.02 | 13.71 | 108 | 43506 | 21693 | 79679081 |
Rib fracture | 132.48 | 13.71 | 115 | 43499 | 27832 | 79672942 |
Femoral neck fracture | 129.64 | 13.71 | 76 | 43538 | 9908 | 79690866 |
Neutropenia | 128.83 | 13.71 | 7 | 43607 | 287703 | 79413071 |
Vertebroplasty | 127.24 | 13.71 | 30 | 43584 | 262 | 79700512 |
Completed suicide | 116.55 | 13.71 | 4 | 43610 | 245763 | 79455011 |
Lumbar vertebral fracture | 114.33 | 13.71 | 62 | 43552 | 6960 | 79693814 |
Febrile neutropenia | 112.29 | 13.71 | 3 | 43611 | 230996 | 79469778 |
Product dose omission issue | 108.95 | 13.71 | 340 | 43274 | 247197 | 79453577 |
Thoracic vertebral fracture | 98.60 | 13.71 | 51 | 43563 | 5202 | 79695572 |
Product use in unapproved indication | 91.18 | 13.71 | 14 | 43600 | 250345 | 79450429 |
Spinal compression fracture | 91.09 | 13.71 | 75 | 43539 | 16883 | 79683891 |
Asthenia | 89.04 | 13.71 | 530 | 43084 | 511159 | 79189615 |
Foot fracture | 83.70 | 13.71 | 80 | 43534 | 21901 | 79678873 |
Drug interaction | 83.61 | 13.71 | 63 | 43551 | 415120 | 79285654 |
Nephrolithiasis | 81.91 | 13.71 | 122 | 43492 | 53169 | 79647605 |
Drug intolerance | 81.22 | 13.71 | 22 | 43592 | 264097 | 79436677 |
Treatment failure | 73.70 | 13.71 | 5 | 43609 | 170481 | 79530293 |
Pyrexia | 72.91 | 13.71 | 165 | 43449 | 678544 | 79022230 |
Infusion related reaction | 71.12 | 13.71 | 19 | 43595 | 230218 | 79470556 |
Palpitations | 68.18 | 13.71 | 187 | 43427 | 126423 | 79574351 |
Humerus fracture | 67.05 | 13.71 | 49 | 43565 | 9264 | 79691510 |
Drug abuse | 66.88 | 13.71 | 6 | 43608 | 162685 | 79538089 |
Nausea | 66.69 | 13.71 | 807 | 42807 | 956389 | 78744385 |
Thrombocytopenia | 66.38 | 13.71 | 31 | 43583 | 265228 | 79435546 |
Blood alkaline phosphatase increased | 65.88 | 13.71 | 122 | 43492 | 63542 | 79637232 |
Compression fracture | 65.52 | 13.71 | 42 | 43572 | 6418 | 79694356 |
Pain | 64.02 | 13.71 | 626 | 42988 | 703176 | 78997598 |
Synovitis | 63.50 | 13.71 | 5 | 43609 | 150729 | 79550045 |
Atypical femur fracture | 63.44 | 13.71 | 38 | 43576 | 5151 | 79695623 |
Disease progression | 63.38 | 13.71 | 12 | 43602 | 184350 | 79516424 |
Heart rate increased | 59.80 | 13.71 | 173 | 43441 | 120551 | 79580223 |
Pathological fracture | 59.53 | 13.71 | 48 | 43566 | 10489 | 79690285 |
Therapeutic product effect incomplete | 58.83 | 13.71 | 5 | 43609 | 141640 | 79559134 |
Osteitis deformans | 58.20 | 13.71 | 15 | 43599 | 195 | 79700579 |
Calciphylaxis | 57.82 | 13.71 | 32 | 43582 | 3738 | 79697036 |
Chronic obstructive pulmonary disease | 57.20 | 13.71 | 137 | 43477 | 85282 | 79615492 |
Body height decreased | 54.76 | 13.71 | 42 | 43572 | 8538 | 79692236 |
Hand fracture | 54.69 | 13.71 | 37 | 43577 | 6188 | 79694586 |
Contusion | 53.48 | 13.71 | 191 | 43423 | 148585 | 79552189 |
Gait disturbance | 53.42 | 13.71 | 240 | 43374 | 207266 | 79493508 |
Malignant neoplasm progression | 53.33 | 13.71 | 6 | 43608 | 135984 | 79564790 |
Surgery | 53.22 | 13.71 | 77 | 43537 | 32689 | 79668085 |
Bone disorder | 51.86 | 13.71 | 58 | 43556 | 19055 | 79681719 |
Therapeutic product effect decreased | 49.70 | 13.71 | 14 | 43600 | 163849 | 79536925 |
Tibia fracture | 47.42 | 13.71 | 32 | 43582 | 5329 | 79695445 |
Stress fracture | 46.43 | 13.71 | 34 | 43580 | 6446 | 79694328 |
Nervousness | 46.41 | 13.71 | 73 | 43541 | 33342 | 79667432 |
Urine calcium increased | 46.06 | 13.71 | 11 | 43603 | 102 | 79700672 |
Patella fracture | 45.97 | 13.71 | 22 | 43592 | 1899 | 79698875 |
Breast cancer | 44.44 | 13.71 | 72 | 43542 | 33709 | 79667065 |
Cerebrovascular accident | 44.07 | 13.71 | 185 | 43429 | 155107 | 79545667 |
Stomatitis | 43.65 | 13.71 | 13 | 43601 | 146744 | 79554030 |
Headache | 43.10 | 13.71 | 546 | 43068 | 653226 | 79047548 |
Hand deformity | 42.25 | 13.71 | 4 | 43610 | 103915 | 79596859 |
Neck pain | 42.19 | 13.71 | 113 | 43501 | 75304 | 79625470 |
Myalgia | 42.12 | 13.71 | 207 | 43407 | 185434 | 79515340 |
Blood parathyroid hormone increased | 41.53 | 13.71 | 25 | 43589 | 3420 | 79697354 |
Diarrhoea | 41.41 | 13.71 | 297 | 43317 | 880192 | 78820582 |
Injection site rash | 41.22 | 13.71 | 50 | 43564 | 17904 | 79682870 |
Product use issue | 40.71 | 13.71 | 33 | 43581 | 209789 | 79490985 |
Musculoskeletal discomfort | 40.36 | 13.71 | 52 | 43562 | 19783 | 79680991 |
Hypotension | 39.54 | 13.71 | 117 | 43497 | 440200 | 79260574 |
Hepatic enzyme increased | 38.95 | 13.71 | 26 | 43588 | 182584 | 79518190 |
Post procedural complication | 38.70 | 13.71 | 56 | 43558 | 23773 | 79677001 |
Ankle fracture | 38.54 | 13.71 | 47 | 43567 | 16922 | 79683852 |
Intentional overdose | 38.38 | 13.71 | 6 | 43608 | 105954 | 79594820 |
Lower limb fracture | 38.35 | 13.71 | 55 | 43559 | 23160 | 79677614 |
Radius fracture | 38.21 | 13.71 | 24 | 43590 | 3540 | 79697234 |
Fracture nonunion | 38.16 | 13.71 | 18 | 43596 | 1504 | 79699270 |
Multiple fractures | 37.97 | 13.71 | 33 | 43581 | 7993 | 79692781 |
Pericarditis | 37.53 | 13.71 | 6 | 43608 | 104230 | 79596544 |
Leukopenia | 37.14 | 13.71 | 9 | 43605 | 116504 | 79584270 |
Ulna fracture | 36.48 | 13.71 | 16 | 43598 | 1129 | 79699645 |
Pancytopenia | 36.16 | 13.71 | 23 | 43591 | 165722 | 79535052 |
Lower respiratory tract infection | 35.70 | 13.71 | 13 | 43601 | 129207 | 79571567 |
Bradycardia | 35.21 | 13.71 | 15 | 43599 | 135542 | 79565232 |
Cervical vertebral fracture | 35.06 | 13.71 | 23 | 43591 | 3655 | 79697119 |
Platelet count decreased | 34.88 | 13.71 | 33 | 43581 | 194631 | 79506143 |
Neutrophil count decreased | 34.76 | 13.71 | 5 | 43609 | 93954 | 79606820 |
Intentional product use issue | 34.73 | 13.71 | 20 | 43594 | 152092 | 79548682 |
Drug hypersensitivity | 34.21 | 13.71 | 70 | 43544 | 298846 | 79401928 |
Balance disorder | 33.89 | 13.71 | 125 | 43489 | 98732 | 79602042 |
White blood cell count decreased | 33.64 | 13.71 | 32 | 43582 | 188256 | 79512518 |
Blood calcium abnormal | 33.52 | 13.71 | 16 | 43598 | 1373 | 79699401 |
Breast cancer in situ | 32.69 | 13.71 | 14 | 43600 | 932 | 79699842 |
Injury associated with device | 31.19 | 13.71 | 21 | 43593 | 3485 | 79697289 |
Fractured sacrum | 30.97 | 13.71 | 16 | 43598 | 1627 | 79699147 |
Wheezing | 30.15 | 13.71 | 13 | 43601 | 116651 | 79584123 |
Bone scan abnormal | 30.04 | 13.71 | 9 | 43605 | 209 | 79700565 |
Osteoporotic fracture | 29.82 | 13.71 | 22 | 43592 | 4218 | 79696556 |
Complication associated with device | 29.71 | 13.71 | 42 | 43572 | 17454 | 79683320 |
Suicide attempt | 29.35 | 13.71 | 5 | 43609 | 82927 | 79617847 |
Recalled product | 29.33 | 13.71 | 13 | 43601 | 941 | 79699833 |
Glossodynia | 29.22 | 13.71 | 10 | 43604 | 103327 | 79597447 |
Hypercalciuria | 29.09 | 13.71 | 11 | 43603 | 529 | 79700245 |
Osteonecrosis | 28.96 | 13.71 | 57 | 43557 | 31038 | 79669736 |
Osteocalcin increased | 28.62 | 13.71 | 5 | 43609 | 6 | 79700768 |
Helicobacter infection | 27.51 | 13.71 | 3 | 43611 | 69701 | 79631073 |
Incorrect product administration duration | 26.82 | 13.71 | 33 | 43581 | 11989 | 79688785 |
Device failure | 26.16 | 13.71 | 24 | 43590 | 6237 | 79694537 |
Vertigo | 25.93 | 13.71 | 90 | 43524 | 68992 | 79631782 |
Duodenal ulcer perforation | 25.75 | 13.71 | 3 | 43611 | 66208 | 79634566 |
Calcium ionised increased | 25.63 | 13.71 | 8 | 43606 | 214 | 79700560 |
Calcinosis | 25.54 | 13.71 | 16 | 43598 | 2349 | 79698425 |
Medication error | 25.40 | 13.71 | 89 | 43525 | 68553 | 79632221 |
Neuropathy peripheral | 25.25 | 13.71 | 24 | 43590 | 141281 | 79559493 |
Injection site irritation | 25.17 | 13.71 | 19 | 43595 | 3771 | 79697003 |
Fear | 25.12 | 13.71 | 44 | 43570 | 21942 | 79678832 |
Metabolic acidosis | 25.11 | 13.71 | 7 | 43607 | 82522 | 79618252 |
Memory impairment | 24.90 | 13.71 | 124 | 43490 | 111610 | 79589164 |
Hyperkalaemia | 24.77 | 13.71 | 16 | 43598 | 114382 | 79586392 |
Dystrophic calcification | 24.74 | 13.71 | 7 | 43607 | 132 | 79700642 |
Multiple organ dysfunction syndrome | 24.47 | 13.71 | 18 | 43596 | 120228 | 79580546 |
Agitation | 24.39 | 13.71 | 12 | 43602 | 99703 | 79601071 |
Hallucination, synaesthetic | 24.20 | 13.71 | 6 | 43608 | 66 | 79700708 |
Head injury | 24.00 | 13.71 | 59 | 43555 | 37310 | 79663464 |
Anaphylactic reaction | 23.86 | 13.71 | 8 | 43606 | 83735 | 79617039 |
Vitamin D decreased | 23.83 | 13.71 | 28 | 43586 | 9697 | 79691077 |
Cementoplasty | 23.81 | 13.71 | 4 | 43610 | 3 | 79700771 |
Bone fissure | 23.47 | 13.71 | 7 | 43607 | 160 | 79700614 |
General physical health deterioration | 23.35 | 13.71 | 75 | 43539 | 275163 | 79425611 |
Rhabdomyolysis | 22.92 | 13.71 | 14 | 43600 | 103117 | 79597657 |
Wound | 22.86 | 13.71 | 18 | 43596 | 116161 | 79584613 |
Cardio-respiratory arrest | 22.40 | 13.71 | 16 | 43598 | 108494 | 79592280 |
Dementia Alzheimer's type | 22.37 | 13.71 | 11 | 43603 | 1008 | 79699766 |
Injection site discolouration | 22.21 | 13.71 | 24 | 43590 | 7590 | 79693184 |
Sternal fracture | 22.14 | 13.71 | 15 | 43599 | 2515 | 79698259 |
Product distribution issue | 21.95 | 13.71 | 12 | 43602 | 1368 | 79699406 |
Alanine aminotransferase increased | 21.32 | 13.71 | 35 | 43579 | 162535 | 79538239 |
Gammopathy | 21.26 | 13.71 | 7 | 43607 | 223 | 79700551 |
Hyperparathyroidism | 21.05 | 13.71 | 16 | 43598 | 3208 | 79697566 |
Liver injury | 20.97 | 13.71 | 3 | 43611 | 56611 | 79644163 |
Weight decreased | 20.97 | 13.71 | 291 | 43323 | 354907 | 79345867 |
Anaemia | 20.89 | 13.71 | 150 | 43464 | 444865 | 79255909 |
Cardiac disorder | 20.75 | 13.71 | 81 | 43533 | 65676 | 79635098 |
C-reactive protein increased | 20.71 | 13.71 | 24 | 43590 | 129003 | 79571771 |
Colon cancer | 20.54 | 13.71 | 32 | 43582 | 14491 | 79686283 |
Enchondromatosis | 20.51 | 13.71 | 5 | 43609 | 51 | 79700723 |
Urinary bladder polyp | 20.39 | 13.71 | 7 | 43607 | 254 | 79700520 |
Depressed level of consciousness | 20.28 | 13.71 | 14 | 43600 | 96638 | 79604136 |
Wrong technique in device usage process | 19.94 | 13.71 | 17 | 43597 | 4011 | 79696763 |
Parkinson's disease | 19.82 | 13.71 | 12 | 43602 | 1659 | 79699115 |
Arrhythmia | 19.77 | 13.71 | 76 | 43538 | 61196 | 79639578 |
Dyspnoea | 19.75 | 13.71 | 340 | 43274 | 856685 | 78844089 |
Fibula fracture | 19.21 | 13.71 | 16 | 43598 | 3658 | 79697116 |
Injection site urticaria | 19.18 | 13.71 | 29 | 43585 | 12797 | 79687977 |
Road traffic accident | 19.17 | 13.71 | 60 | 43554 | 43604 | 79657170 |
Musculoskeletal chest pain | 19.09 | 13.71 | 42 | 43572 | 24722 | 79676052 |
Growing pains | 19.06 | 13.71 | 4 | 43610 | 19 | 79700755 |
Lung neoplasm malignant | 19.05 | 13.71 | 45 | 43569 | 27747 | 79673027 |
Systemic lupus erythematosus | 18.95 | 13.71 | 23 | 43591 | 121126 | 79579648 |
Angioedema | 18.82 | 13.71 | 9 | 43605 | 76026 | 79624748 |
Intestinal obstruction | 18.78 | 13.71 | 59 | 43555 | 42961 | 79657813 |
Hip surgery | 18.75 | 13.71 | 15 | 43599 | 3240 | 79697534 |
Groin pain | 18.75 | 13.71 | 29 | 43585 | 13051 | 79687723 |
Prosthesis implantation | 18.15 | 13.71 | 5 | 43609 | 85 | 79700689 |
Vein disorder | 18.11 | 13.71 | 18 | 43596 | 5164 | 79695610 |
Leukaemia | 17.85 | 13.71 | 19 | 43595 | 5906 | 79694868 |
Extraskeletal ossification | 17.83 | 13.71 | 5 | 43609 | 91 | 79700683 |
Breast calcifications | 17.82 | 13.71 | 9 | 43605 | 873 | 79699901 |
Bone cancer | 17.77 | 13.71 | 12 | 43602 | 2000 | 79698774 |
Death | 17.74 | 13.71 | 420 | 43194 | 566094 | 79134680 |
Rash | 17.66 | 13.71 | 217 | 43397 | 578141 | 79122633 |
Manufacturing product shipping issue | 17.49 | 13.71 | 5 | 43609 | 98 | 79700676 |
Laryngeal pain | 17.36 | 13.71 | 19 | 43595 | 6095 | 79694679 |
Pain in jaw | 17.21 | 13.71 | 60 | 43554 | 46091 | 79654683 |
Face injury | 17.20 | 13.71 | 15 | 43599 | 3649 | 79697125 |
Type 2 diabetes mellitus | 17.09 | 13.71 | 5 | 43609 | 57117 | 79643657 |
Back disorder | 17.06 | 13.71 | 26 | 43588 | 11552 | 79689222 |
Delirium | 16.79 | 13.71 | 13 | 43601 | 84614 | 79616160 |
Clavicle fracture | 16.78 | 13.71 | 16 | 43598 | 4365 | 79696409 |
Muscle disorder | 16.66 | 13.71 | 18 | 43596 | 5689 | 79695085 |
Encephalopathy | 16.65 | 13.71 | 8 | 43606 | 67389 | 79633385 |
Tetany | 16.64 | 13.71 | 13 | 43601 | 2715 | 79698059 |
Atypical fracture | 16.64 | 13.71 | 8 | 43606 | 698 | 79700076 |
Abdominal pain | 16.53 | 13.71 | 135 | 43479 | 389434 | 79311340 |
Skeletal injury | 16.52 | 13.71 | 10 | 43604 | 1382 | 79699392 |
Cardiac pacemaker insertion | 16.37 | 13.71 | 18 | 43596 | 5804 | 79694970 |
Wrong product stored | 16.24 | 13.71 | 3 | 43611 | 6 | 79700768 |
Drug ineffective for unapproved indication | 16.24 | 13.71 | 4 | 43610 | 51234 | 79649540 |
N-telopeptide urine increased | 16.22 | 13.71 | 4 | 43610 | 43 | 79700731 |
Limb discomfort | 16.17 | 13.71 | 47 | 43567 | 32803 | 79667971 |
Blood bilirubin increased | 16.15 | 13.71 | 8 | 43606 | 66224 | 79634550 |
Extrasystoles | 15.96 | 13.71 | 20 | 43594 | 7399 | 79693375 |
Cystocele | 15.92 | 13.71 | 8 | 43606 | 768 | 79700006 |
Pseudarthrosis | 15.80 | 13.71 | 6 | 43608 | 292 | 79700482 |
Hip arthroplasty | 15.58 | 13.71 | 49 | 43565 | 35707 | 79665067 |
Plasma cell myeloma | 15.52 | 13.71 | 64 | 43550 | 53195 | 79647579 |
Blister | 15.40 | 13.71 | 26 | 43588 | 119450 | 79581324 |
Pneumonitis | 15.38 | 13.71 | 7 | 43607 | 60853 | 79639921 |
Emphysema | 15.32 | 13.71 | 30 | 43584 | 16270 | 79684504 |
Agranulocytosis | 15.32 | 13.71 | 3 | 43611 | 45027 | 79655747 |
Breast enlargement | 15.30 | 13.71 | 10 | 43604 | 1579 | 79699195 |
Oestrogen receptor assay positive | 15.20 | 13.71 | 6 | 43608 | 324 | 79700450 |
Neoplasm malignant | 15.17 | 13.71 | 45 | 43569 | 31765 | 79669009 |
Cardiac flutter | 15.13 | 13.71 | 16 | 43598 | 4938 | 79695836 |
Hernia repair | 15.11 | 13.71 | 11 | 43603 | 2067 | 79698707 |
Fatigue | 14.99 | 13.71 | 636 | 42978 | 929091 | 78771683 |
Loss of consciousness | 14.97 | 13.71 | 149 | 43465 | 167794 | 79532980 |
Oxygen saturation decreased | 14.93 | 13.71 | 30 | 43584 | 129017 | 79571757 |
Spondylolisthesis | 14.91 | 13.71 | 13 | 43601 | 3162 | 79697612 |
Rash maculo-papular | 14.89 | 13.71 | 6 | 43608 | 56072 | 79644702 |
Exostosis of jaw | 14.86 | 13.71 | 9 | 43605 | 1245 | 79699529 |
Suicidal ideation | 14.80 | 13.71 | 12 | 43602 | 76328 | 79624446 |
Unresponsive to stimuli | 14.76 | 13.71 | 6 | 43608 | 55782 | 79644992 |
Hepatitis | 14.73 | 13.71 | 6 | 43608 | 55721 | 79645053 |
Tremor | 14.73 | 13.71 | 150 | 43464 | 169933 | 79530841 |
Sedation | 14.71 | 13.71 | 5 | 43609 | 51890 | 79648884 |
Sleep disorder due to general medical condition, insomnia type | 14.61 | 13.71 | 3 | 43611 | 43553 | 79657221 |
Aspartate aminotransferase increased | 14.58 | 13.71 | 34 | 43580 | 138607 | 79562167 |
Breast cancer female | 14.49 | 13.71 | 24 | 43590 | 11437 | 79689337 |
Intervertebral disc compression | 14.46 | 13.71 | 9 | 43605 | 1307 | 79699467 |
Femoral hernia | 14.34 | 13.71 | 3 | 43611 | 14 | 79700760 |
Pollakiuria | 14.33 | 13.71 | 49 | 43565 | 37268 | 79663506 |
Transient ischaemic attack | 14.33 | 13.71 | 62 | 43552 | 52633 | 79648141 |
Osteonecrosis of jaw | 14.26 | 13.71 | 54 | 43560 | 43172 | 79657602 |
Blood calcium decreased | 14.22 | 13.71 | 44 | 43570 | 31775 | 79668999 |
Spinal deformity | 14.09 | 13.71 | 8 | 43606 | 982 | 79699792 |
Psoriasis | 14.01 | 13.71 | 17 | 43597 | 89570 | 79611204 |
Dysstasia | 13.95 | 13.71 | 40 | 43574 | 27706 | 79673068 |
Pallor | 13.88 | 13.71 | 5 | 43609 | 50057 | 79650717 |
Basosquamous carcinoma of skin | 13.85 | 13.71 | 3 | 43611 | 17 | 79700757 |
Fractured coccyx | 13.85 | 13.71 | 8 | 43606 | 1014 | 79699760 |
Septic shock | 13.83 | 13.71 | 29 | 43585 | 122772 | 79578002 |
None
Source | Code | Description |
---|---|---|
ATC | H05AA02 | SYSTEMIC HORMONAL PREPARATIONS, EXCL. SEX HORMONES AND INSULINS CALCIUM HOMEOSTASIS PARATHYROID HORMONES AND ANALOGUES Parathyroid hormones and analogues |
FDA CS | M0015931 | Parathyroid Hormone |
FDA EPC | N0000180852 | Parathyroid Hormone Analog |
MeSH PA | D050071 | Bone Density Conservation Agents |
MeSH PA | D000077264 | Calcium-Regulating Hormones and Agents |
Disease | Relation | SNOMED_ID | DOID |
---|---|---|---|
Postmenopausal osteoporosis | indication | 102447009 | |
Hypogonadal Osteoporosis in Males | indication | ||
Glucocorticoid Induced Osteoporosis | indication | ||
Osteitis deformans | contraindication | 2089002 | DOID:5408 |
Osteomalacia | contraindication | 4598005 | DOID:10573 |
Renal osteodystrophy | contraindication | 16726004 | DOID:13068 |
Hepatic osteodystrophy | contraindication | 28193003 | |
Rickets | contraindication | 41345002 | DOID:10609 |
Low blood pressure | contraindication | 45007003 | |
Metabolic bone disease | contraindication | 50279003 | |
Hypercalcemia | contraindication | 66931009 | DOID:12678 |
Hyperparathyroidism | contraindication | 66999008 | DOID:13543 |
Osteitis fibrosa cystica generalisata | contraindication | 84727000 | DOID:3341 |
Metastatic malignant neoplasm to bone | contraindication | 94222008 | |
Urolithiasis | contraindication | 95566004 | |
Renal impairment | contraindication | 236423003 | |
Alkaline phosphatase raised | contraindication | 274770006 | |
Pregnancy, function | contraindication | 289908002 | |
Osteosarcoma of bone | contraindication | 307576001 | DOID:3376 |
Breastfeeding (mother) | contraindication | 413712001 | |
Malignant neoplasm of skeletal system | contraindication | 443679004 | |
Radiation Therapy Involving Bone | contraindication | ||
Bone Metastases | contraindication |
None
None
Dissociation level | Dissociation constant | Type (acidic/basic) |
---|---|---|
pKa1 | 3.23 | acidic |
pKa2 | 3.31 | acidic |
pKa3 | 3.82 | acidic |
pKa4 | 4.11 | acidic |
pKa5 | 4.44 | acidic |
pKa6 | 11.68 | acidic |
pKa7 | 12.17 | acidic |
pKa8 | 12.35 | acidic |
pKa9 | 12.6 | acidic |
pKa10 | 12.63 | acidic |
pKa11 | 12.75 | acidic |
pKa12 | 12.78 | acidic |
pKa13 | 12.93 | acidic |
pKa14 | 13.16 | acidic |
pKa15 | 13.18 | acidic |
pKa16 | 13.37 | acidic |
pKa17 | 13.37 | acidic |
pKa18 | 13.44 | acidic |
pKa19 | 13.47 | acidic |
pKa20 | 13.57 | acidic |
pKa21 | 13.72 | acidic |
pKa22 | 13.72 | acidic |
pKa23 | 13.74 | acidic |
pKa24 | 13.82 | acidic |
pKa25 | 13.89 | acidic |
pKa26 | 11.47 | Basic |
pKa27 | 11.08 | Basic |
pKa28 | 10.81 | Basic |
pKa29 | 10.48 | Basic |
pKa30 | 10.09 | Basic |
pKa31 | 7.63 | Basic |
pKa32 | 7.16 | Basic |
pKa33 | 6.69 | Basic |
pKa34 | 6.21 | Basic |
None
None
Target | Class | Pharos | UniProt | Action | Type | Activity value (-log[M]) | Mechanism action | Bioact source | MoA source |
---|---|---|---|---|---|---|---|---|---|
Parathyroid hormone/parathyroid hormone-related peptide receptor | GPCR | AGONIST | IC50 | 7.40 | IUPHAR | CHEMBL | |||
Parathyroid hormone 2 receptor | GPCR | AGONIST | IC50 | 7.80 | IUPHAR | ||||
Parathyroid hormone 2 receptor | GPCR | AGONIST | IC50 | 6.30 | IUPHAR | ||||
Parathyroid hormone/parathyroid hormone-related peptide receptor | GPCR | AGONIST | IC50 | 8.70 | IUPHAR |
ID | Source |
---|---|
D03358 | KEGG_DRUG |
4019512 | VUID |
N0000147632 | NUI |
4019512 | VANDF |
CHEBI:135983 | CHEBI |
CHEMBL525610 | ChEMBL_ID |
4448 | IUPHAR_LIGAND_ID |
5411 | INN_ID |
99294-94-7 | SECONDARY_CAS_RN |
DB06285 | DRUGBANK_ID |
10T9CSU89I | UNII |
114260 | RXNORM |
17041 | MMSL |
336918 | MMSL |
d04828 | MMSL |
002142 | NDDF |
004944 | NDDF |
109198008 | SNOMEDCT_US |
398823001 | SNOMEDCT_US |
425438001 | SNOMEDCT_US |
C0070093 | UMLSCUI |
D019379 | MESH_DESCRIPTOR_UI |
CHEMBL1201549 | ChEMBL_ID |
16132393 | PUBCHEM_CID |
Product | Category | Ingredients | NDC | Form | Quantity | Route | Marketing | Label |
---|---|---|---|---|---|---|---|---|
Forteo | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0002-8400 | INJECTION, SOLUTION | 250 ug | SUBCUTANEOUS | NDA | 35 sections |
teriparatide | HUMAN PRESCRIPTION DRUG LABEL | 1 | 47781-652 | INJECTION, SOLUTION | 250 ug | SUBCUTANEOUS | NDA | 30 sections |
teriparatide | HUMAN PRESCRIPTION DRUG LABEL | 1 | 47781-652 | INJECTION, SOLUTION | 250 ug | SUBCUTANEOUS | NDA | 30 sections |