magnesium silicate 🐶 Veterinary Use | Indications/Contra | FAERs-F | FAERs-M | Orange Bk | BioActivity |

Stem definitionDrug idCAS RN
4513 14987-04-3

Description:

MoleculeDescription

Synonyms:

  • magnesium silicate
  • magnesium trisilicate
  • trisilicalm
  • magnesium mesotrisilicate
hard, porous, granular substance used in vitamin analysis, chromatography, & antibiotic processing
  • Molecular weight: 260.86
  • Formula: Mg2O8Si3
  • CLOGP:
  • LIPINSKI: None
  • HAC: None
  • HDO: None
  • TPSA: 144.84
  • ALOGS:
  • ROTB: None

Drug dosage:

None

ADMET properties:

None

Approvals:

DateAgencyCompanyOrphan
Dec. 9, 1983 FDA SANOFI AVENTIS US

FDA Adverse Event Reporting System (Female)

MedDRA adverse event termLikelihood ratioLikelihood ratio thresholdPatients taking drug having adverse eventPatients taking drug not having adverse eventPatients not taking drug having adverse eventPatients not taking drug not having adverse event
Hyponatraemia 34.68 24.09 31 2409 111869 63374713
Acute kidney injury 31.01 24.09 44 2396 263371 63223211
Coma scale abnormal 29.44 24.09 10 2430 5143 63481439
Maternal drugs affecting foetus 29.27 24.09 10 2430 5232 63481350
Morbid thoughts 27.17 24.09 6 2434 617 63485965
Vomiting 25.49 24.09 62 2378 559555 62927027
Confusional state 24.21 24.09 37 2403 236343 63250239

FDA Adverse Event Reporting System (Male)

MedDRA adverse event termLikelihood ratioLikelihood ratio thresholdPatients taking drug having adverse eventPatients taking drug not having adverse eventPatients not taking drug having adverse eventPatients not taking drug not having adverse event
Appendicolith 81.26 22.69 28 2332 8573 34945998
Blood phosphorus increased 80.25 22.69 27 2333 7694 34946877
Appendicitis 69.83 22.69 29 2331 14778 34939793
Cardiogenic shock 59.26 22.69 31 2329 26587 34927984
Ventricular fibrillation 57.66 22.69 29 2331 22925 34931646
Dry mouth 52.90 22.69 30 2330 30135 34924436
Myasthenia gravis 51.89 22.69 19 2341 6921 34947650
Stress 50.06 22.69 29 2331 30318 34924253
Blood uric acid increased 49.27 22.69 20 2340 9604 34944967
Mesothelioma 48.13 22.69 10 2350 435 34954136
Abdominal distension 47.73 22.69 36 2324 58456 34896115
Hyponatraemia 42.63 22.69 39 2321 82652 34871919
Ascites 36.50 22.69 28 2332 46543 34908028
Multiple organ dysfunction syndrome 35.39 22.69 34 2326 76532 34878039
Blood cholesterol increased 34.83 22.69 20 2340 20523 34934048
Vomiting 33.79 22.69 60 2300 247561 34707010
General physical health deterioration 28.55 22.69 39 2321 128230 34826341
Abdominal pain 25.35 22.69 42 2318 163576 34790995
Violence-related symptom 24.71 22.69 6 2354 530 34954041
Incorrect route of product administration 23.95 22.69 14 2346 14831 34939740

FDA Adverse Event Reporting System (Geriatric)

MedDRA adverse event termLikelihood ratioLikelihood ratio thresholdPatients taking drug having adverse eventPatients taking drug not having adverse eventPatients not taking drug having adverse eventPatients not taking drug not having adverse event
Appendicolith 90.94 19.83 28 3773 8523 79732064
Blood phosphorus increased 85.69 19.83 28 3773 10319 79730268
Appendicitis 70.00 19.83 29 3772 20765 79719822
Hyponatraemia 68.23 19.83 61 3740 177787 79562800
Ventricular fibrillation 61.07 19.83 30 3771 31896 79708691
Cardiogenic shock 53.38 19.83 30 3771 41884 79698703
Myasthenia gravis 50.82 19.83 19 3782 10380 79730207
Blood uric acid increased 49.63 19.83 20 3781 13340 79727247
Abdominal distension 43.77 19.83 40 3761 119610 79620977
Dry mouth 39.37 19.83 33 3768 87986 79652601
Vomiting 39.22 19.83 93 3708 665735 79074852
Violence-related symptom 35.53 19.83 8 3793 723 79739864
Stress 33.86 19.83 29 3772 79583 79661004
Ascites 33.10 19.83 28 3773 75534 79665053
Multiple organ dysfunction syndrome 30.60 19.83 33 3768 120213 79620374
General physical health deterioration 30.20 19.83 50 3751 275188 79465399
Morbid thoughts 24.38 19.83 6 3795 796 79739791
Drug ineffective 23.76 19.83 11 3790 1080902 78659685
Mesothelioma 23.34 19.83 5 3796 359 79740228
Abdominal pain 22.38 19.83 54 3747 389515 79351072
Coma scale abnormal 22.28 19.83 10 3791 8668 79731919
Hyperphosphataemia 21.81 19.83 9 3792 6367 79734220
Blood cholesterol increased 21.32 19.83 23 3778 83697 79656890
Iron deficiency 20.32 19.83 10 3791 10644 79729943

FDA Adverse Event Reporting System (Pediatric)

None

Pharmacologic Action:

SourceCodeDescription
ATC A02AA05 ALIMENTARY TRACT AND METABOLISM
DRUGS FOR ACID RELATED DISORDERS
ANTACIDS
Magnesium compounds
MeSH PA D000863 Antacids
MeSH PA D005765 Gastrointestinal Agents

Drug Use | Suggest Off label Use Form| |View source of the data|

DiseaseRelationSNOMED_IDDOID
Peptic ulcer indication 13200003 DOID:750
Heartburn indication 16331000
Indigestion indication 162031009
Gastroesophageal reflux disease indication 235595009 DOID:8534
Gastric Hypersecretory Conditions indication
Hiatal Hernia with Reflux Esophagitis indication
Multiple endocrine adenomas off-label use 60549007
Systemic mast cell disease off-label use 397016004 DOID:349
Stress-Related GI Mucosal Bleeding Prevention off-label use
Hypophosphatemia contraindication 4996001
Constipation contraindication 14760008 DOID:2089
Fecal impaction contraindication 44635007
Chronic heart failure contraindication 48447003
Acute nephropathy contraindication 58574008
Diarrhea contraindication 62315008
Hemorrhoids contraindication 70153002 DOID:9746
Oliguria contraindication 83128009
Kidney disease contraindication 90708001 DOID:557
Gastrointestinal obstruction contraindication 126765001
Chronic diarrhea contraindication 236071009
Aluminum intoxication contraindication 236546003
Edema contraindication 267038008




🐶 Veterinary Drug Use

None

🐶 Veterinary products

None

Acid dissociation constants calculated using MoKa v3.0.0

None

Orange Book patent data (new drug applications)

None

Orange Book exclusivity data (new drug applications)

None

Bioactivity Summary:

None

External reference:

IDSource
9B9691B2N9 UNII
D03271 KEGG_DRUG
39365-87-2 SECONDARY_CAS_RN
4019384 VANDF
C0851342 UMLSCUI
CHEMBL2109133 ChEMBL_ID
66225 PUBCHEM_CID
DB13249 DRUGBANK_ID
CHEMBL2096633 ChEMBL_ID
C005013 MESH_SUPPLEMENTAL_RECORD_UI
C001671 MESH_SUPPLEMENTAL_RECORD_UI
DB09281 DRUGBANK_ID
1310566 RXNORM
5018 MMSL
5593 MMSL
d03587 MMSL
001121 NDDF
008286 NDDF
21691008 SNOMEDCT_US
387117008 SNOMEDCT_US
1343-88-0 SECONDARY_CAS_RN

Pharmaceutical products:

ProductCategoryIngredientsNDCFormQuantityRouteMarketingLabel
GavisconRegular Strength HUMAN OTC DRUG LABEL 2 0135-0096 TABLET, CHEWABLE 14.20 mg ORAL NDA 15 sections
GavisconRegular Strength HUMAN OTC DRUG LABEL 2 0135-0096 TABLET, CHEWABLE 14.20 mg ORAL NDA 15 sections
VIRUS BLOCKER CL-40 HUMAN OTC DRUG LABEL 1 80965-201 STICK 80 g TOPICAL unapproved drug other 11 sections