magnesium silicate 🐶 Veterinary Use | Indications/Contra | FAERs-F | FAERs-M | Orange Bk | BioActivity |

Stem definition	Drug id	CAS RN
	4513	14987-04-3

Description:

Molecule	Description
Synonyms: magnesium silicate magnesium trisilicate trisilicalm magnesium mesotrisilicate	hard, porous, granular substance used in vitamin analysis, chromatography, & antibiotic processing Molecular weight: 260.86 Formula: Mg2O8Si3 CLOGP: LIPINSKI: None HAC: None HDO: None TPSA: 144.84 ALOGS: ROTB: None

Molecule

Description

Synonyms:

magnesium silicate
magnesium trisilicate
trisilicalm
magnesium mesotrisilicate

hard, porous, granular substance used in vitamin analysis, chromatography, & antibiotic processing

Molecular weight: 260.86
Formula: Mg2O8Si3
CLOGP:
LIPINSKI: None
HAC: None
HDO: None
TPSA: 144.84
ALOGS:
ROTB: None

Drug dosage:

None

ADMET properties:

None

Approvals:

Date	Agency	Company	Orphan
Dec. 9, 1983	FDA	SANOFI AVENTIS US

FDA Adverse Event Reporting System (Female)

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MedDRA adverse event term	Likelihood ratio	Likelihood ratio threshold	Patients taking drug having adverse event	Patients taking drug not having adverse event	Patients not taking drug having adverse event	Patients not taking drug not having adverse event
Hyponatraemia	34.68	24.09	31	2409	111869	63374713
Acute kidney injury	31.01	24.09	44	2396	263371	63223211
Coma scale abnormal	29.44	24.09	10	2430	5143	63481439
Maternal drugs affecting foetus	29.27	24.09	10	2430	5232	63481350
Morbid thoughts	27.17	24.09	6	2434	617	63485965
Vomiting	25.49	24.09	62	2378	559555	62927027
Confusional state	24.21	24.09	37	2403	236343	63250239

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FDA Adverse Event Reporting System (Male)

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MedDRA adverse event term	Likelihood ratio	Likelihood ratio threshold	Patients taking drug having adverse event	Patients taking drug not having adverse event	Patients not taking drug having adverse event	Patients not taking drug not having adverse event
Appendicolith	81.26	22.69	28	2332	8573	34945998
Blood phosphorus increased	80.25	22.69	27	2333	7694	34946877
Appendicitis	69.83	22.69	29	2331	14778	34939793
Cardiogenic shock	59.26	22.69	31	2329	26587	34927984
Ventricular fibrillation	57.66	22.69	29	2331	22925	34931646
Dry mouth	52.90	22.69	30	2330	30135	34924436
Myasthenia gravis	51.89	22.69	19	2341	6921	34947650
Stress	50.06	22.69	29	2331	30318	34924253
Blood uric acid increased	49.27	22.69	20	2340	9604	34944967
Mesothelioma	48.13	22.69	10	2350	435	34954136

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FDA Adverse Event Reporting System (Geriatric)

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MedDRA adverse event term	Likelihood ratio	Likelihood ratio threshold	Patients taking drug having adverse event	Patients taking drug not having adverse event	Patients not taking drug having adverse event	Patients not taking drug not having adverse event
Appendicolith	90.94	19.83	28	3773	8523	79732064
Blood phosphorus increased	85.69	19.83	28	3773	10319	79730268
Appendicitis	70.00	19.83	29	3772	20765	79719822
Hyponatraemia	68.23	19.83	61	3740	177787	79562800
Ventricular fibrillation	61.07	19.83	30	3771	31896	79708691
Cardiogenic shock	53.38	19.83	30	3771	41884	79698703
Myasthenia gravis	50.82	19.83	19	3782	10380	79730207
Blood uric acid increased	49.63	19.83	20	3781	13340	79727247
Abdominal distension	43.77	19.83	40	3761	119610	79620977
Dry mouth	39.37	19.83	33	3768	87986	79652601

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FDA Adverse Event Reporting System (Pediatric)

None

Pharmacologic Action:

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Source	Code	Description
ATC	A02AA05	ALIMENTARY TRACT AND METABOLISM DRUGS FOR ACID RELATED DISORDERS ANTACIDS Magnesium compounds
MeSH PA	D000863	Antacids
MeSH PA	D005765	Gastrointestinal Agents

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Drug Use | Suggest Off label Use Form| |View source of the data|

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Disease	Relation	SNOMED_ID	DOID
Peptic ulcer	indication	13200003	DOID:750
Heartburn	indication	16331000
Indigestion	indication	162031009
Gastroesophageal reflux disease	indication	235595009	DOID:8534
Gastric Hypersecretory Conditions	indication
Hiatal Hernia with Reflux Esophagitis	indication
Multiple endocrine adenomas	off-label use	60549007
Systemic mast cell disease	off-label use	397016004	DOID:349
Stress-Related GI Mucosal Bleeding Prevention	off-label use
Hypophosphatemia	contraindication	4996001

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🐶 Veterinary Drug Use

None

🐶 Veterinary products

None

Acid dissociation constants calculated using MoKa v3.0.0

None

Orange Book patent data (new drug applications)

None

Orange Book exclusivity data (new drug applications)

None

Bioactivity Summary:

None

External reference:

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ID	Source
001121	NDDF
008286	NDDF
1310566	RXNORM
1343-88-0	SECONDARY_CAS_RN
21691008	SNOMEDCT_US
387117008	SNOMEDCT_US
39365-87-2	SECONDARY_CAS_RN
4019384	VANDF
5018	MMSL
5593	MMSL

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Pharmaceutical products:

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Product	Category	Ingredients	NDC	Form	Quantity	Route	Marketing	Label
GavisconRegular Strength	HUMAN OTC DRUG LABEL	2	0135-0096	TABLET, CHEWABLE	14.20 mg	ORAL	NDA	15 sections
GavisconRegular Strength	HUMAN OTC DRUG LABEL	2	0135-0096	TABLET, CHEWABLE	14.20 mg	ORAL	NDA	15 sections
VIRUS BLOCKER CL-40	HUMAN OTC DRUG LABEL	1	80965-201	STICK	80 g	TOPICAL	unapproved drug other	11 sections

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