magnesium silicate 🐶 Veterinary Use | Indications/Contra | FAERs-F | FAERs-M | Orange Bk | PK/Tox | Related Drugs | BioActivity |

Stem definitionDrug idCAS RN
4513 14987-04-3

Description:

MoleculeDescription

Synonyms:

  • magnesium silicate
  • magnesium trisilicate
  • trisilicalm
  • magnesium mesotrisilicate
hard, porous, granular substance used in vitamin analysis, chromatography, & antibiotic processing
  • Molecular weight: 260.86
  • Formula: Mg2O8Si3
  • CLOGP:
  • LIPINSKI: None
  • HAC: None
  • HDO: None
  • TPSA: 144.84
  • ALOGS:
  • ROTB: None

Drug dosage:

None

ADMET properties:

None

Predicted pharmacokinetic/toxicological properties (PK-AZ):

None

Approvals:

DateAgencyCompanyOrphan
Dec. 9, 1983 FDA SANOFI AVENTIS US

FDA Adverse Event Reporting System (Female)

MedDRA adverse event termLikelihood ratioLikelihood ratio thresholdPatients taking drug having adverse eventPatients taking drug not having adverse eventPatients not taking drug having adverse eventPatients not taking drug not having adverse event
Carbuncle 96.61 71.20 16 879 1420 90626132
Monoclonal immunoglobulin present 90.36 71.20 16 879 2108 90625444
Hypothalamo-pituitary disorder 89.42 71.20 16 879 2236 90625316
Wrist deformity 83.62 71.20 16 879 3222 90624330
Overweight 73.96 71.20 16 879 5918 90621634
Fibrosis 73.91 71.20 16 879 5936 90621616

FDA Adverse Event Reporting System (Male)

MedDRA adverse event termLikelihood ratioLikelihood ratio thresholdPatients taking drug having adverse eventPatients taking drug not having adverse eventPatients not taking drug having adverse eventPatients not taking drug not having adverse event
Appendicolith 127.15 69.73 40 1951 13416 42605928
Appendicitis 114.17 69.73 41 1950 20572 42598772
Blood phosphorus increased 109.08 69.73 35 1956 12490 42606854
Ventricular fibrillation 95.68 69.73 40 1951 30083 42589261
Myasthenia gravis 88.95 69.73 32 1959 16105 42603239
Dry mouth 84.90 69.73 40 1951 39839 42579505
Stress 83.97 69.73 41 1950 44171 42575173
Cardiogenic shock 82.86 69.73 38 1953 35602 42583742
Blood uric acid increased 75.17 69.73 28 1963 15519 42603825
Ascites 74.36 69.73 41 1950 56637 42562707

FDA Adverse Event Reporting System (Geriatric)

MedDRA adverse event termLikelihood ratioLikelihood ratio thresholdPatients taking drug having adverse eventPatients taking drug not having adverse eventPatients not taking drug having adverse eventPatients not taking drug not having adverse event
Appendicolith 147.84 50.07 40 2840 14215 110572204
Appendicitis 124.56 50.07 41 2839 28423 110557996
Blood phosphorus increased 119.98 50.07 35 2845 16305 110570114
Ventricular fibrillation 105.97 50.07 40 2840 41273 110545146
Myasthenia gravis 98.18 50.07 32 2848 21479 110564940
Cardiogenic shock 86.72 50.07 38 2842 57300 110529119
Blood uric acid increased 82.20 50.07 28 2852 21501 110564918
Carbuncle 80.68 50.07 16 2864 1451 110584968
Ascites 77.75 50.07 41 2839 92767 110493652
Stress 72.88 50.07 41 2839 105307 110481112
Diabetes mellitus 72.35 50.07 40 2840 99341 110487078
Monoclonal immunoglobulin present 71.93 50.07 16 2864 2524 110583895
Hypothalamo-pituitary disorder 70.11 50.07 16 2864 2830 110583589
Hyperphosphataemia 69.23 50.07 23 2857 16358 110570061
Wrist deformity 68.30 50.07 16 2864 3173 110583246
Overweight 57.08 50.07 16 2864 6448 110579971
Hypophosphataemia 56.74 50.07 24 2856 33158 110553261
Abdominal distension 56.06 50.07 42 2838 175061 110411358
Fibrosis 54.43 50.07 16 2864 7626 110578793
Multiple organ dysfunction syndrome 52.17 50.07 38 2842 151672 110434747
Iron deficiency 51.39 50.07 19 2861 18457 110567962

FDA Adverse Event Reporting System (Pediatric)

None

Pharmacologic Action:

SourceCodeDescription
ATC A02AA05 ALIMENTARY TRACT AND METABOLISM
DRUGS FOR ACID RELATED DISORDERS
ANTACIDS
Magnesium compounds
MeSH PA D000863 Antacids
MeSH PA D005765 Gastrointestinal Agents

Related Drugs by ATC class:

A02AA Magnesium compounds 4 drugs
magnesium carbonatemagnesium hydroxidemagnesium oxidemagnesium peroxide

Drug Use | Suggest Off label Use Form| |View source of the data|

DiseaseRelationSNOMED_IDDOID
Peptic ulcer indication 13200003 DOID:750
Heartburn indication 16331000
Indigestion indication 162031009
Gastroesophageal reflux disease indication 235595009 DOID:8534
Gastric Hypersecretory Conditions indication
Hiatal Hernia with Reflux Esophagitis indication
Multiple endocrine adenomas off-label use 60549007
Systemic mast cell disease off-label use 397016004 DOID:349
Stress-Related GI Mucosal Bleeding Prevention off-label use
Hypophosphatemia contraindication 4996001
Constipation contraindication 14760008 DOID:2089
Fecal impaction contraindication 44635007
Chronic heart failure contraindication 48447003
Acute nephropathy contraindication 58574008
Diarrhea contraindication 62315008
Hemorrhoids contraindication 70153002 DOID:9746
Oliguria contraindication 83128009
Kidney disease contraindication 90708001 DOID:557
Gastrointestinal obstruction contraindication 126765001
Chronic diarrhea contraindication 236071009
Aluminum intoxication contraindication 236546003
Edema contraindication 267038008




🐶 Veterinary Drug Use

None

🐶 Veterinary products

None

Acid dissociation constants calculated using MoKa v3.0.0

None

Orange Book patent data (new drug applications)

None

Orange Book exclusivity data (new drug applications)

None

Bioactivity Summary:

None

External reference:

IDSource
9B9691B2N9 UNII
D03271 KEGG_DRUG
39365-87-2 SECONDARY_CAS_RN
4019384 VANDF
C0851342 UMLSCUI
CHEBI:754025 CHEBI
CHEMBL2109133 ChEMBL_ID
72941442 PUBCHEM_CID
DB13249 DRUGBANK_ID
CHEMBL2096633 ChEMBL_ID
C005013 MESH_SUPPLEMENTAL_RECORD_UI
C001671 MESH_SUPPLEMENTAL_RECORD_UI
DB09281 DRUGBANK_ID
1310566 RXNORM
5018 MMSL
5593 MMSL
d03587 MMSL
001121 NDDF
008286 NDDF
21691008 SNOMEDCT_US
387117008 SNOMEDCT_US
1343-88-0 SECONDARY_CAS_RN

Pharmaceutical products:

ProductCategoryIngredientsNDCFormQuantityRouteMarketingLabel
VIRUS BLOCKER CL-40 HUMAN OTC DRUG LABEL 1 80965-201 STICK 80 g TOPICAL unapproved drug other 11 sections