lithium citrate 🐶 Veterinary Use | Indications/Contra | FAERs-F | FAERs-M | Orange Bk | BioActivity |

Stem definitionDrug idCAS RN
4512 919-16-4

Description:

MoleculeDescription

Synonyms:

  • lithium citrate
  • trilithium citrate
  • lithonate
  • lithium citrate hydrate
  • Molecular weight: 209.92
  • Formula: C6H5Li3O7
  • CLOGP:
  • LIPINSKI: None
  • HAC: None
  • HDO: None
  • TPSA: 140.62
  • ALOGS:
  • ROTB: None

Drug dosage:

DoseUnitRoute
24 mmol O

ADMET properties:

None

Approvals:

DateAgencyCompanyOrphan
Dec. 23, 1980 FDA ROXANE

FDA Adverse Event Reporting System (Female)

MedDRA adverse event termLikelihood ratioLikelihood ratio thresholdPatients taking drug having adverse eventPatients taking drug not having adverse eventPatients not taking drug having adverse eventPatients not taking drug not having adverse event
Toxicity to various agents 1249.66 12.88 1183 41125 211316 50351500
Nephrogenic diabetes insipidus 621.95 12.88 145 42163 736 50562080
Neuroleptic malignant syndrome 615.88 12.88 260 42048 10870 50551946
Tremor 596.39 12.88 599 41709 114304 50448512
Mania 470.76 12.88 214 42094 10702 50552114
Drug interaction 443.84 12.88 679 41629 198942 50363874
Hypomania 348.58 12.88 134 42174 4371 50558445
Psychotic disorder 319.41 12.88 209 42099 21603 50541213
Extrapyramidal disorder 313.16 12.88 166 42142 11604 50551212
Antipsychotic drug level increased 308.47 12.88 111 42197 2998 50559818
Completed suicide 304.46 12.88 457 41851 131432 50431384
Hyperparathyroidism 296.34 12.88 101 42207 2313 50560503
Tardive dyskinesia 268.16 12.88 128 42180 7151 50555665
Ataxia 259.59 12.88 155 42153 13631 50549185
Schizophrenia 254.14 12.88 124 42184 7273 50555543
Agitation 248.69 12.88 263 42045 53121 50509695
Sedation 233.06 12.88 198 42110 30412 50532404
Suicidal ideation 209.95 12.88 245 42063 55140 50507676
Bipolar disorder 207.62 12.88 105 42203 6652 50556164
Catatonia 195.72 12.88 84 42224 3652 50559164
Pain 184.59 12.88 130 42178 578773 49984043
Akathisia 180.02 12.88 102 42206 8127 50554689
Suicide attempt 176.61 12.88 217 42091 51515 50511301
Hypernatraemia 164.87 12.88 88 42220 6233 50556583
Antipsychotic drug level above therapeutic 161.62 12.88 51 42257 908 50561908
Pleurothotonus 157.99 12.88 54 42254 1247 50561569
Drug level increased 157.72 12.88 130 42178 19138 50543678
Serotonin syndrome 156.43 12.88 144 42164 24569 50538247
Confusional state 152.75 12.88 419 41889 185509 50377307
Parkinsonism 144.88 12.88 91 42217 8756 50554060
Delirium 144.77 12.88 169 42139 38023 50524793
Dysarthria 144.27 12.88 167 42141 37236 50525580
Salivary hypersecretion 142.29 12.88 81 42227 6510 50556306
Delusion 141.93 12.88 96 42212 10473 50552343
Disorientation 139.49 12.88 160 42148 35324 50527492
Diabetes insipidus 136.63 12.88 57 42251 2307 50560509
Aggression 135.50 12.88 124 42184 20992 50541824
Arthralgia 130.00 12.88 106 42202 438596 50124220
Jaundice cholestatic 127.27 12.88 69 42239 5042 50557774
Overdose 126.37 12.88 266 42042 99461 50463355
Hallucination, auditory 124.29 12.88 89 42219 10639 50552177
Polyuria 123.57 12.88 76 42232 7045 50555771
Rheumatoid arthritis 120.73 12.88 14 42294 202536 50360280
Muscle rigidity 119.55 12.88 84 42224 9745 50553071
Dyspnoea 113.55 12.88 177 42131 547431 50015385
Myoclonus 110.91 12.88 94 42214 14376 50548440
Mental status changes 107.70 12.88 142 42166 36130 50526686
Infusion related reaction 105.45 12.88 10 42298 169547 50393269
Intentional overdose 103.89 12.88 187 42121 62317 50500499
Systemic lupus erythematosus 103.72 12.88 3 42305 140619 50422197
Irritability 103.09 12.88 123 42185 28303 50534513
Swelling 99.46 12.88 23 42285 200849 50361967
Weight increased 99.34 12.88 382 41926 201509 50361307
Intentional self-injury 99.00 12.88 109 42199 23003 50539813
Abnormal behaviour 97.09 12.88 100 42208 19558 50543258
Joint swelling 96.79 12.88 42 42266 245244 50317572
Hypothyroidism 95.81 12.88 130 42178 33995 50528821
Disturbance in attention 95.55 12.88 124 42184 31062 50531754
Contraindicated product administered 94.74 12.88 8 42300 148950 50413866
Nasopharyngitis 93.72 12.88 23 42285 192904 50369912
Neurotoxicity 93.47 12.88 86 42222 14654 50548162
Arthropathy 91.41 12.88 12 42296 157894 50404922
Somnolence 90.38 12.88 310 41998 154675 50408141
Polydipsia 88.59 12.88 46 42262 3078 50559738
Obsessive-compulsive disorder 85.70 12.88 46 42262 3294 50559522
Granulocytopenia 83.62 12.88 53 42255 5178 50557638
Mental disorder 82.78 12.88 97 42211 21894 50540922
Depression 81.31 12.88 313 41995 165110 50397706
Glossodynia 79.98 12.88 4 42304 115565 50447251
Hypersensitivity 79.98 12.88 40 42268 215121 50347695
Hyperreflexia 77.22 12.88 50 42258 5068 50557748
Electrocardiogram QT prolonged 77.14 12.88 148 42160 51738 50511078
Body tinea 76.70 12.88 32 42276 1295 50561521
Alopecia 76.50 12.88 56 42252 244991 50317825
Sinusitis 74.23 12.88 25 42283 170533 50392283
Camptocormia 72.17 12.88 21 42287 280 50562536
Libido increased 71.93 12.88 30 42278 1213 50561603
Fatigue 70.96 12.88 328 41980 707273 49855543
Abdominal discomfort 70.93 12.88 54 42254 231587 50331229
Dystonia 70.65 12.88 67 42241 11859 50550957
Inhibitory drug interaction 69.47 12.88 35 42273 2198 50560618
Nephropathy 68.78 12.88 47 42261 5211 50557605
Peripheral swelling 68.34 12.88 44 42264 205892 50356924
Antipsychotic drug level below therapeutic 68.30 12.88 20 42288 273 50562543
Poisoning 66.44 12.88 66 42242 12363 50550453
Dyskinesia 66.17 12.88 98 42210 27763 50535053
Apathy 66.13 12.88 53 42255 7495 50555321
Hypercalcaemia 65.60 12.88 89 42219 23263 50539553
Postural tremor 64.61 12.88 18 42290 203 50562613
Parathyroid tumour benign 64.61 12.88 23 42285 601 50562215
Depressed mood 64.61 12.88 108 42200 33915 50528901
Aphasia 64.49 12.88 98 42210 28396 50534420
Grandiosity 64.31 12.88 19 42289 268 50562548
Blood prolactin increased 63.99 12.88 37 42271 3062 50559754
Drug abuse 62.66 12.88 148 42160 59698 50503118
Mutism 62.44 12.88 28 42280 1353 50561463
Sopor 62.38 12.88 80 42228 19799 50543017
Cogwheel rigidity 61.66 12.88 30 42278 1747 50561069
Anticholinergic syndrome 61.37 12.88 30 42278 1765 50561051
Paranoia 61.04 12.88 58 42250 10290 50552526
Psychomotor hyperactivity 60.40 12.88 55 42253 9246 50553570
Stomatitis 60.35 12.88 7 42301 101337 50461479
Anaemia 59.73 12.88 74 42234 252382 50310434
Depressed level of consciousness 59.37 12.88 133 42175 51820 50510996
Restlessness 59.00 12.88 88 42220 25085 50537731
Drug intolerance 58.66 12.88 58 42250 219046 50343770
Treatment noncompliance 57.64 12.88 96 42212 30054 50532762
Logorrhoea 56.82 12.88 31 42277 2293 50560523
Cough 56.78 12.88 71 42237 241193 50321623
Infection susceptibility increased 56.43 12.88 32 42276 2552 50560264
Chronic kidney disease 56.13 12.88 111 42197 39660 50523156
Personality disorder 55.02 12.88 38 42270 4286 50558530
Pain in extremity 54.65 12.88 90 42218 272775 50290041
Pruritus 54.52 12.88 96 42212 283472 50279344
Rash 54.36 12.88 186 42122 437285 50125531
Glucose tolerance impaired 53.70 12.88 40 42268 5078 50557738
Back pain 53.62 12.88 63 42245 219967 50342849
Brugada syndrome 53.34 12.88 17 42291 313 50562503
Schizoaffective disorder 52.75 12.88 29 42279 2177 50560639
Hostility 52.72 12.88 27 42281 1755 50561061
Tachyphrenia 52.36 12.88 24 42284 1221 50561595
Electrocardiogram T wave abnormal 52.18 12.88 29 42279 2224 50560592
Stupor 51.60 12.88 34 42274 3549 50559267
Bipolar I disorder 50.79 12.88 25 42283 1493 50561323
Resting tremor 50.51 12.88 20 42288 706 50562110
Treatment failure 50.49 12.88 26 42282 137611 50425205
Altered state of consciousness 49.08 12.88 75 42233 21835 50540981
Encephalopathy 48.67 12.88 95 42213 33616 50529200
Psychiatric symptom 48.58 12.88 36 42272 4534 50558282
Anxiety 47.58 12.88 282 42026 177324 50385492
Disease progression 47.36 12.88 11 42297 95855 50466961
Hepatotoxicity 47.19 12.88 83 42225 27143 50535673
Action tremor 46.52 12.88 15 42293 287 50562529
Speech disorder 46.34 12.88 96 42212 35452 50527364
Leukocytosis 46.01 12.88 74 42234 22505 50540311
Infection 44.89 12.88 47 42261 172907 50389909
Febrile neutropenia 44.82 12.88 13 42295 97654 50465162
Death 44.81 12.88 132 42176 325247 50237569
Gastrointestinal disorder 44.41 12.88 12 42296 94444 50468372
Renal cyst 44.36 12.88 45 42263 8642 50554174
Atrial fibrillation 44.09 12.88 15 42293 101730 50461086
Cardio-respiratory arrest 43.66 12.88 121 42187 53771 50509045
Galactorrhoea 43.38 12.88 31 42277 3692 50559124
Euphoric mood 43.24 12.88 32 42276 4023 50558793
Poor quality sleep 43.09 12.88 61 42247 16585 50546231
Substance abuse 42.75 12.88 32 42276 4092 50558724
Sleep-related eating disorder 42.65 12.88 18 42290 750 50562066
Soft tissue injury 42.50 12.88 22 42286 1462 50561354
Cholelithiasis 42.03 12.88 96 42212 37877 50524939
Impaired quality of life 41.67 12.88 37 42271 6019 50556797
White blood cell count increased 41.56 12.88 102 42206 42138 50520678
Drooling 41.33 12.88 29 42279 3355 50559461
Diarrhoea 41.09 12.88 306 42002 588170 49974646
Asterixis 41 12.88 20 42288 1171 50561645
Drug reaction with eosinophilia and systemic symptoms 40.91 12.88 80 42228 28344 50534472
Cognitive disorder 40.74 12.88 104 42204 44019 50518797
Oculogyric crisis 40.29 12.88 21 42287 1416 50561400
Mental impairment 40.22 12.88 50 42258 11994 50550822
Anger 39.38 12.88 48 42260 11285 50551531
Headache 37.96 12.88 258 42050 506277 50056539
Persecutory delusion 37.69 12.88 24 42284 2363 50560453
Enuresis 37.64 12.88 23 42285 2106 50560710
Goitre 37.59 12.88 33 42275 5287 50557529
Thinking abnormal 37.34 12.88 43 42265 9524 50553292
Parkinsonian gait 37.26 12.88 14 42294 428 50562388
Hallucination 37.04 12.88 104 42204 46553 50516263
Neutrophil count increased 36.71 12.88 52 42256 14143 50548673
Impaired healing 36.53 12.88 7 42301 69779 50493037
Therapeutic product effect decreased 36.40 12.88 36 42272 136014 50426802
Abdominal pain upper 36.29 12.88 48 42260 159261 50403555
Injection site erythema 36.22 12.88 9 42299 74927 50487889
Blood bilirubin increased 35.46 12.88 81 42227 31957 50530859
Visuospatial deficit 35.28 12.88 7 42301 13 50562803
Gastrointestinal haemorrhage 35.07 12.88 9 42299 73312 50489504
Post-traumatic neck syndrome 34.71 12.88 21 42287 1889 50560927
Blister 34.64 12.88 14 42294 85404 50477412
Respiratory arrest 34.47 12.88 77 42231 29932 50532884
Lethargy 34.28 12.88 105 42203 49327 50513489
Urticaria 33.84 12.88 35 42273 129526 50433290
Hyperlipidaemia 33.84 12.88 56 42252 17434 50545382
Sternal fracture 33.80 12.88 21 42287 1981 50560835
Insomnia 33.76 12.88 256 42052 174609 50388207
Choreoathetosis 33.69 12.88 13 42295 428 50562388
Hallucination, visual 33.31 12.88 54 42254 16528 50546288
Electrocardiogram T wave inversion 33.13 12.88 25 42283 3236 50559580
Bradykinesia 33.08 12.88 27 42281 3916 50558900
Blood creatine phosphokinase increased 32.95 12.88 70 42238 26297 50536519
Arthritis 32.36 12.88 16 42292 86705 50476111
Cardiac failure congestive 32.36 12.88 15 42293 84367 50478449
Renal oncocytoma 32.00 12.88 7 42301 25 50562791
Schizoaffective disorder bipolar type 31.87 12.88 9 42299 107 50562709
Clonus 31.73 12.88 27 42281 4148 50558668
Impulsive behaviour 31.69 12.88 18 42290 1440 50561376
Cerebellar atrophy 31.68 12.88 14 42294 653 50562163
Haemodialysis 31.66 12.88 37 42271 8325 50554491
Electroencephalogram abnormal 31.57 12.88 25 42283 3474 50559342
Myocarditis 31.49 12.88 36 42272 7911 50554905
Papillary thyroid cancer 31.17 12.88 20 42288 1995 50560821
Drug level above therapeutic 31.13 12.88 26 42282 3894 50558922
Product use issue 31.11 12.88 48 42260 149427 50413389
Bronchitis 30.93 12.88 25 42283 104134 50458682
Pressure of speech 30.82 12.88 13 42295 541 50562275
Hereditary ataxia 30.80 12.88 7 42301 31 50562785
Mood swings 30.76 12.88 51 42257 15903 50546913
Muscle twitching 30.65 12.88 50 42258 15381 50547435
Chest pain 30.36 12.88 64 42244 176818 50385998
Blood sodium increased 30.31 12.88 21 42287 2381 50560435
Hyperprolactinaemia 30.27 12.88 24 42284 3341 50559475
Abdominal pain 30.24 12.88 99 42209 236129 50326687
Hypothermia 29.58 12.88 43 42265 11973 50550843
Acute psychosis 29.41 12.88 20 42288 2200 50560616
Hyperthyroidism 29.15 12.88 43 42265 12132 50550684
Discomfort 28.62 12.88 29 42279 108351 50454465
Drug withdrawal syndrome 28.41 12.88 64 42244 25017 50537799
Maternal exposure during pregnancy 28.11 12.88 57 42251 159721 50403095
Eye movement disorder 27.81 12.88 26 42282 4519 50558297
Nodal rhythm 27.69 12.88 17 42291 1570 50561246
Intentional product use issue 27.50 12.88 15 42293 76903 50485913
Social avoidant behaviour 27.44 12.88 21 42287 2776 50560040
Purpura 26.66 12.88 37 42271 9874 50552942
Neuropathy peripheral 26.57 12.88 25 42283 96732 50466084
Bradyphrenia 26.31 12.88 29 42279 6123 50556693
Impaired self-care 26.15 12.88 17 42291 1734 50561082
Hallucinations, mixed 26.13 12.88 24 42284 4079 50558737
Psychiatric decompensation 25.92 12.88 15 42293 1243 50561573
Bruxism 25.89 12.88 21 42287 3019 50559797
Ammonia increased 25.45 12.88 24 42284 4217 50558599
Major depression 25.29 12.88 30 42278 6854 50555962
International normalised ratio abnormal 24.98 12.88 20 42288 2823 50559993
Depressive symptom 24.95 12.88 21 42287 3179 50559637
Differential white blood cell count abnormal 24.85 12.88 12 42296 687 50562129
Affect lability 24.82 12.88 34 42274 8964 50553852
Feeling guilty 24.78 12.88 11 42297 519 50562297
Muscle contractions involuntary 24.71 12.88 17 42291 1905 50560911
Antidepressant drug level increased 24.70 12.88 9 42299 252 50562564
Sepsis 24.61 12.88 46 42262 132879 50429937
Injection site swelling 24.57 12.88 3 42305 41770 50521046
Ileus paralytic 24.46 12.88 23 42285 4027 50558789
Rhabdomyolysis 24.40 12.88 80 42228 38947 50523869
Thyrotoxic crisis 24.02 12.88 12 42296 740 50562076
Withdrawal syndrome 23.50 12.88 48 42260 17542 50545274
Asthma 23.47 12.88 24 42284 89313 50473503
Lower respiratory tract infection 23.44 12.88 27 42281 95174 50467642
Ideas of reference 23.42 12.88 7 42301 103 50562713
Nystagmus 23.41 12.88 26 42282 5535 50557281
Memory impairment 23.17 12.88 129 42179 79231 50483585
Cerebrovascular accident 23.15 12.88 27 42281 94653 50468163
Pneumonia 23.00 12.88 204 42104 378197 50184619
Adams-Stokes syndrome 22.96 12.88 6 42302 52 50562764
Thrombosis 22.88 12.88 9 42299 55824 50506992
Histrionic personality disorder 22.76 12.88 6 42302 54 50562762
Fibromyalgia 22.53 12.88 5 42303 44973 50517843
Urinary incontinence 22.51 12.88 63 42245 28145 50534671
Electroconvulsive therapy 22.10 12.88 6 42302 61 50562755
Blunted affect 22.09 12.88 8 42300 220 50562596
Cerebral atrophy 21.98 12.88 23 42285 4578 50558238
Limbic encephalitis 21.92 12.88 8 42300 225 50562591
Decreased appetite 21.89 12.88 90 42218 200833 50361983
Musculoskeletal pain 21.83 12.88 17 42291 72160 50490656
Anaphylactic reaction 21.68 12.88 9 42299 54046 50508770
Acute kidney injury 21.56 12.88 288 42020 227770 50335046
Hyperammonaemia 21.48 12.88 23 42285 4701 50558115
Electrocardiogram abnormal 21.37 12.88 29 42279 7576 50555240
Thrombocytopenia 21.23 12.88 47 42261 127626 50435190
International normalised ratio increased 21.21 12.88 5 42303 43147 50519669
Coordination abnormal 21.07 12.88 36 42272 11498 50551318
Osteoarthritis 20.95 12.88 16 42292 68590 50494226
Cardiac hypertrophy 20.93 12.88 12 42296 977 50561839
Injection site pain 20.92 12.88 38 42270 110986 50451830
Neuropsychiatric symptoms 20.77 12.88 10 42298 569 50562247
Mobility decreased 20.42 12.88 22 42286 79926 50482890
Bone pain 20.39 12.88 7 42301 47222 50515594
Cerebellar syndrome 20.37 12.88 19 42289 3292 50559524
Flat affect 20.30 12.88 13 42295 1292 50561524
Self-injurious ideation 20.27 12.88 16 42292 2213 50560603
Psoriatic arthropathy 20.25 12.88 7 42301 47025 50515791
Refusal of treatment by patient 20.20 12.88 23 42285 5030 50557786
Nephropathy toxic 20.16 12.88 29 42279 8000 50554816
Knee arthroplasty 20.07 12.88 3 42305 35843 50526973
Drug level decreased 20.04 12.88 26 42282 6507 50556309
Lactate pyruvate ratio increased 19.97 12.88 6 42302 90 50562726
Somatic symptom disorder 19.96 12.88 15 42293 1929 50560887
Hypotonia 19.87 12.88 29 42279 8105 50554711
Mood altered 19.67 12.88 37 42271 12736 50550080
Merycism 19.62 12.88 7 42301 184 50562632
Delusion of reference 19.44 12.88 6 42302 99 50562717
Platelet count decreased 19.40 12.88 34 42274 100692 50462124
General physical health deterioration 19.40 12.88 58 42250 142376 50420440
Paraesthesia 19.40 12.88 45 42263 120198 50442618
Essential tremor 19.36 12.88 11 42297 880 50561936
Dialysis 19.32 12.88 31 42277 9407 50553409
Hypertonia 19.23 12.88 20 42288 3953 50558863
Sluggishness 19.21 12.88 21 42287 4392 50558424
Arachnoid cyst 19.21 12.88 7 42301 196 50562620
Mydriasis 19.19 12.88 33 42275 10594 50552222
Hyporeflexia 19.16 12.88 14 42294 1726 50561090
Drug hypersensitivity 19.15 12.88 127 42181 250883 50311933
Impaired work ability 19.15 12.88 38 42270 13602 50549214
Borderline personality disorder 19.13 12.88 10 42298 678 50562138
Lipids decreased 19.07 12.88 4 42304 11 50562805
Mucosal inflammation 19.05 12.88 5 42303 40137 50522679
Oxygen saturation decreased 18.88 12.88 20 42288 73228 50489588
Staring 18.86 12.88 13 42295 1461 50561355
Clear cell renal cell carcinoma 18.76 12.88 12 42296 1191 50561625
Lung disorder 18.72 12.88 7 42301 44792 50518024
Acquired cystic kidney disease 18.58 12.88 5 42303 49 50562767
Thyroiditis 18.58 12.88 14 42294 1808 50561008
Neurological symptom 18.57 12.88 21 42287 4561 50558255
Unresponsive to stimuli 18.47 12.88 62 42246 30547 50532269
Influenza 18.38 12.88 29 42279 89509 50473307
Urine osmolarity increased 18.36 12.88 6 42302 120 50562696
Negativism 18.33 12.88 8 42300 362 50562454
Dyspnoea exertional 18.30 12.88 10 42298 51223 50511593
Bone density decreased 18.21 12.88 33 42275 11042 50551774
Affective disorder 18.09 12.88 22 42286 5159 50557657
Pleural effusion 18.07 12.88 25 42283 81429 50481387
Antidepressant drug level above therapeutic 18.07 12.88 8 42300 375 50562441
Nausea 18.01 12.88 451 41857 704947 49857869
Septic shock 17.89 12.88 13 42295 57162 50505654
Dysphoria 17.86 12.88 21 42287 4753 50558063
Productive cough 17.80 12.88 11 42297 52683 50510133
Oscillopsia 17.78 12.88 6 42302 133 50562683
Compulsive sexual behaviour 17.74 12.88 5 42303 59 50562757
Blood citric acid increased 17.74 12.88 5 42303 59 50562757
Seizure 17.62 12.88 163 42145 117711 50445105
Compartment syndrome 17.54 12.88 14 42294 1968 50560848
Homicidal ideation 17.18 12.88 13 42295 1689 50561127
Haemoglobin decreased 17.18 12.88 52 42256 127164 50435652
Epileptic encephalopathy 17.12 12.88 7 42301 269 50562547
Toxic encephalopathy 16.99 12.88 22 42286 5493 50557323
Tonsillar hypertrophy 16.98 12.88 10 42298 856 50561960
Slow response to stimuli 16.95 12.88 10 42298 859 50561957
Middle insomnia 16.87 12.88 30 42278 9891 50552925
Sleep apnoea syndrome 16.82 12.88 51 42257 23817 50538999
Bundle branch block right 16.67 12.88 20 42288 4625 50558191
Urinary retention 16.65 12.88 54 42254 26136 50536680
Neonatal respiratory distress 16.55 12.88 7 42301 293 50562523
Amenorrhoea 16.19 12.88 27 42281 8457 50554359
Acalculia 16.19 12.88 3 42305 3 50562813
Echolalia 16.17 12.88 6 42302 177 50562639
Ascites 16.03 12.88 5 42303 35856 50526960
Suspected suicide 15.93 12.88 21 42287 5336 50557480
Tooth injury 15.92 12.88 10 42298 961 50561855
Skin disorder 15.69 12.88 50 42258 23980 50538836
Dysphemia 15.69 12.88 14 42294 2292 50560524
Skin ulcer 15.66 12.88 5 42303 35313 50527503
Concussion 15.54 12.88 25 42283 7603 50555213
Cystitis 15.48 12.88 9 42299 44555 50518261
Thought blocking 15.35 12.88 5 42303 99 50562717
Behaviour disorder 15.31 12.88 14 42294 2366 50560450
Gaze palsy 15.30 12.88 11 42297 1322 50561494
Cardiac failure 15.26 12.88 25 42283 76015 50486801
Gait disturbance 15.24 12.88 192 42116 149813 50413003
Delusional perception 14.96 12.88 6 42302 219 50562597
Status epilepticus 14.95 12.88 34 42274 13372 50549444
Stereotypy 14.93 12.88 7 42301 375 50562441
Decreased activity 14.91 12.88 20 42288 5167 50557649
Cardiac arrest 14.76 12.88 120 42188 83531 50479285
Psychotic disorder due to a general medical condition 14.74 12.88 6 42302 228 50562588
Rhinorrhoea 14.55 12.88 13 42295 51570 50511246
Glomerulonephritis minimal lesion 14.54 12.88 6 42302 236 50562580
Distractibility 14.51 12.88 7 42301 400 50562416
Pain in jaw 14.47 12.88 7 42301 38421 50524395
Haemorrhage 14.44 12.88 14 42294 53427 50509389
Type 2 diabetes mellitus 14.42 12.88 62 42246 34313 50528503
Cerebellar ataxia 14.29 12.88 9 42299 869 50561947
Urine output increased 14.27 12.88 10 42298 1154 50561662
Sinus bradycardia 14.22 12.88 33 42275 13150 50549666
Abulia 14.19 12.88 7 42301 420 50562396
Renal impairment 14.14 12.88 110 42198 75551 50487265
Thought insertion 14.11 12.88 3 42305 9 50562807
Ill-defined disorder 14.00 12.88 15 42293 54639 50508177
Balance disorder 13.96 12.88 104 42204 70486 50492330
Throat irritation 13.91 12.88 4 42304 30235 50532581
Amimia 13.91 12.88 4 42304 51 50562765
Nightmare 13.90 12.88 37 42271 16049 50546767
Increased appetite 13.85 12.88 25 42283 8336 50554480
Femur fracture 13.84 12.88 7 42301 37457 50525359
Neutrophilia 13.83 12.88 16 42292 3559 50559257
Agranulocytosis 13.47 12.88 44 42264 21377 50541439
Melaena 13.43 12.88 3 42305 26861 50535955
Hypokalaemia 13.34 12.88 34 42274 87958 50474858
Electrocardiogram QT interval abnormal 13.27 12.88 5 42303 154 50562662
Hypotonia neonatal 13.25 12.88 9 42299 988 50561828
Gestational diabetes 13.24 12.88 23 42285 7442 50555374
Radial nerve palsy 13.16 12.88 7 42301 492 50562324
Colitis 13.08 12.88 8 42300 38521 50524295
Potentiating drug interaction 12.99 12.88 16 42292 3800 50559016
Metabolic syndrome 12.97 12.88 10 42298 1337 50561479
Sinus arrest 12.94 12.88 11 42297 1687 50561129
Plasma cell myeloma 12.91 12.88 5 42303 31317 50531499
Upper respiratory tract infection 12.91 12.88 22 42286 65876 50496940
Pregnancy with contraceptive patch 12.90 12.88 3 42305 15 50562801

FDA Adverse Event Reporting System (Male)

MedDRA adverse event termLikelihood ratioLikelihood ratio thresholdPatients taking drug having adverse eventPatients taking drug not having adverse eventPatients not taking drug having adverse eventPatients not taking drug not having adverse event
Toxicity to various agents 773.80 14.01 967 32739 172694 29368127
Neuroleptic malignant syndrome 540.21 14.01 294 33412 15854 29524967
Mania 467.16 14.01 218 33488 8445 29532376
Tremor 407.44 14.01 459 33247 73079 29467742
Nephrogenic diabetes insipidus 370.96 14.01 108 33598 1031 29539790
Antipsychotic drug level increased 336.77 14.01 130 33576 3113 29537708
Akathisia 300.74 14.01 149 33557 6593 29534228
Obsessive-compulsive disorder 252.34 14.01 117 33589 4459 29536362
Suicide attempt 245.53 14.01 245 33461 33865 29506956
Antipsychotic drug level below therapeutic 244.37 14.01 90 33616 1884 29538937
Drug interaction 214.68 14.01 599 33107 196786 29344035
Parkinsonism 214.47 14.01 122 33584 7156 29533665
Psychotic disorder 194.12 14.01 171 33535 20183 29520638
Serotonin syndrome 193.29 14.01 160 33546 17352 29523469
Antipsychotic drug level above therapeutic 181.12 14.01 62 33644 1039 29539782
Extrapyramidal disorder 176.93 14.01 125 33581 10706 29530115
Euphoric mood 161.60 14.01 88 33618 4737 29536084
Disinhibition 160.56 14.01 72 33634 2535 29538286
Therapeutic product effect variable 152.30 14.01 63 33643 1814 29539007
Weight increased 151.96 14.01 295 33411 76372 29464449
Granulocytopenia 151.57 14.01 91 33615 5903 29534918
Increased appetite 150.59 14.01 91 33615 5973 29534848
Suicidal ideation 149.60 14.01 191 33515 34525 29506296
Sedation 145.86 14.01 136 33570 17269 29523552
Agitation 137.09 14.01 225 33481 51079 29489742
Aggression 136.81 14.01 185 33521 35356 29505465
Schizophrenia 129.13 14.01 85 33621 6480 29534341
Psychomotor hyperactivity 127.71 14.01 92 33614 8121 29532700
Diabetes insipidus 127.27 14.01 60 33646 2374 29538447
Irritability 126.98 14.01 141 33565 22011 29518810
Hypomania 124.23 14.01 57 33649 2118 29538703
Dysarthria 116.08 14.01 159 33547 30752 29510069
Completed suicide 115.03 14.01 291 33415 89955 29450866
Dyspnoea 102.27 14.01 134 33572 326598 29214223
Febrile neutropenia 100.80 14.01 7 33699 112233 29428588
Ataxia 98.37 14.01 93 33613 12010 29528811
Hallucination, auditory 94.23 14.01 82 33624 9511 29531310
Bipolar disorder 91.09 14.01 53 33653 3242 29537579
Delusion 90.80 14.01 86 33620 11130 29529691
Leukopenia 89.90 14.01 196 33510 55007 29485814
Tardive dyskinesia 88.91 14.01 62 33644 5196 29535625
Salivary hypersecretion 86.55 14.01 70 33636 7339 29533482
Priapism 83.17 14.01 56 33650 4432 29536389
Death 82.89 14.01 166 33540 341918 29198903
Dyskinesia 82.65 14.01 108 33598 19953 29520868
Bruxism 82.60 14.01 39 33667 1548 29539273
Schizoaffective disorder 79.72 14.01 34 33672 1058 29539763
Muscle rigidity 79.71 14.01 74 33632 9337 29531484
Confusional state 79.46 14.01 322 33384 127555 29413266
Abnormal behaviour 77.96 14.01 113 33593 23014 29517807
Myoclonus 76.73 14.01 85 33621 13224 29527597
Oppositional defiant disorder 76.16 14.01 27 33679 504 29540317
Arthralgia 76.04 14.01 32 33674 139585 29401236
Coordination abnormal 74.32 14.01 63 33643 7051 29533770
Hypernatraemia 74.29 14.01 64 33642 7322 29533499
Decreased eye contact 70.86 14.01 25 33681 460 29540361
White blood cell count increased 70.15 14.01 141 33565 37375 29503446
Anaemia 69.54 14.01 76 33630 200875 29339946
Hyperparathyroidism 68.73 14.01 31 33675 1106 29539715
Mental status changes 68.59 14.01 134 33572 34793 29506028
Homicidal ideation 68.19 14.01 40 33666 2484 29538337
Overdose 68.18 14.01 223 33483 79596 29461225
Catatonia 67.06 14.01 49 33657 4419 29536402
Delirium 66.54 14.01 142 33564 39255 29501566
Obesity 65.69 14.01 68 33638 9795 29531026
Cough 62.90 14.01 33 33673 126694 29414127
Cognitive disorder 59.93 14.01 101 33605 23398 29517423
Neutrophil count increased 58.61 14.01 78 33628 14664 29526157
Dyslipidaemia 57.90 14.01 51 33655 6010 29534811
Pain in extremity 57.44 14.01 27 33679 110406 29430415
Malignant neoplasm progression 57.44 14.01 8 33698 73851 29466970
Hyperreflexia 57.22 14.01 37 33669 2735 29538086
Disease progression 56.84 14.01 12 33694 81904 29458917
Neurotoxicity 56.08 14.01 76 33630 14537 29526284
Pain 55.85 14.01 68 33638 171364 29369457
Dystonia 55.74 14.01 62 33644 9687 29531134
Brugada syndrome 55.09 14.01 23 33683 678 29540143
Affect lability 54.93 14.01 39 33667 3363 29537458
Delusion of grandeur 54.81 14.01 20 33686 407 29540414
Pneumonia 54.72 14.01 185 33521 319987 29220834
Somnolence 54.69 14.01 232 33474 93723 29447098
Restlessness 53.60 14.01 93 33613 22052 29518769
Treatment noncompliance 52.56 14.01 97 33609 24130 29516691
Pancytopenia 52.23 14.01 15 33691 83153 29457668
Thinking abnormal 51.91 14.01 45 33661 5191 29535630
Anxiety 51.40 14.01 213 33493 85152 29455669
Electrocardiogram QRS complex prolonged 48.36 14.01 39 33667 4071 29536750
Dystonic tremor 48.26 14.01 15 33691 182 29540639
Interstitial lung disease 47.95 14.01 5 33701 57713 29483108
Prescribed overdose 47.56 14.01 54 33652 8629 29532192
Polydipsia 47.53 14.01 36 33670 3429 29537392
Hypothyroidism 46.86 14.01 73 33633 15833 29524988
Myocarditis 46.70 14.01 60 33646 10896 29529925
Clonus 44.85 14.01 30 33676 2348 29538473
Disorientation 42.66 14.01 100 33606 29415 29511406
Atrial fibrillation 42.27 14.01 35 33671 105611 29435210
Back pain 42.03 14.01 33 33673 102251 29438570
Depressed level of consciousness 41.73 14.01 114 33592 36828 29503993
Failure to suspend medication 41.70 14.01 16 33690 376 29540445
Pruritus 41.68 14.01 43 33663 116806 29424015
Speech disorder 41.12 14.01 86 33620 23430 29517391
Depression 41.11 14.01 199 33507 84948 29455873
Choreoathetosis 40.94 14.01 21 33685 999 29539822
Intentional overdose 40.68 14.01 116 33590 38412 29502409
Oedema peripheral 40.58 14.01 35 33671 103522 29437299
Cardiac failure congestive 39.38 14.01 19 33687 76562 29464259
Thrombocytopenia 39.29 14.01 58 33648 134765 29406056
Peripheral swelling 39.09 14.01 12 33694 63727 29477094
Insomnia 39.01 14.01 202 33504 88559 29452262
Blood creatine phosphokinase increased 38.74 14.01 118 33588 40526 29500295
Drug level above therapeutic 38.08 14.01 31 33675 3279 29537542
Septic shock 37.97 14.01 12 33694 62548 29478273
Affective disorder 37.49 14.01 30 33676 3096 29537725
Paranoia 37.33 14.01 51 33655 9826 29530995
Blood thyroid stimulating hormone decreased 37.11 14.01 24 33682 1774 29539047
General physical health deterioration 36.51 14.01 38 33668 102819 29438002
Gastrointestinal haemorrhage 36.17 14.01 23 33683 79510 29461311
Fatigue 35.99 14.01 213 33493 316608 29224213
Mental impairment 35.77 14.01 48 33658 9093 29531728
Hyperparathyroidism primary 34.98 14.01 11 33695 139 29540682
Apathy 34.85 14.01 39 33667 6132 29534689
Myocardial infarction 34.57 14.01 45 33661 110251 29430570
Distractibility 34.56 14.01 13 33693 289 29540532
Rash 34.19 14.01 107 33599 189712 29351109
Hyperprolactinaemia 33.97 14.01 20 33686 1250 29539571
Grandiosity 33.75 14.01 13 33693 309 29540512
Sepsis 33.74 14.01 70 33636 142612 29398209
Infusion related reaction 33.53 14.01 5 33701 43881 29496940
Trismus 33.31 14.01 25 33681 2348 29538473
Diarrhoea 33.03 14.01 233 33473 332465 29208356
Nephropathy 32.75 14.01 35 33671 5228 29535593
Pressure of speech 32.57 14.01 14 33692 444 29540377
Antipsychotic drug level decreased 32.32 14.01 17 33689 852 29539969
Hyperkinesia 32.16 14.01 21 33685 1578 29539243
Plasma cell myeloma 31.38 14.01 3 33703 37112 29503709
Decreased appetite 31.34 14.01 75 33631 145267 29395554
Abulia 31.10 14.01 14 33692 497 29540324
Psychiatric decompensation 30.86 14.01 20 33686 1484 29539337
Leukaemia 30.42 14.01 29 33677 3781 29537040
Therapeutic product effect incomplete 30.15 14.01 106 33600 39199 29501622
Leukocytosis 29.86 14.01 71 33635 21071 29519750
Logorrhoea 29.69 14.01 23 33683 2265 29538556
Cardiac failure 29.62 14.01 28 33678 79259 29461562
Polyuria 29.33 14.01 39 33667 7323 29533498
Bipolar I disorder 28.93 14.01 15 33691 730 29540091
Tachycardia 28.55 14.01 160 33546 72250 29468571
Mental disorder 28.40 14.01 52 33654 12853 29527968
Sleep disorder 28.28 14.01 76 33630 24310 29516511
Disturbance in attention 28.17 14.01 70 33636 21354 29519467
Blood prolactin increased 28.08 14.01 19 33687 1515 29539306
Lethargy 27.67 14.01 100 33606 37480 29503341
Joint swelling 27.58 14.01 11 33695 49619 29491202
Drug level increased 27.52 14.01 64 33642 18723 29522098
Electrocardiogram QT prolonged 27.33 14.01 97 33609 36040 29504781
Enuresis 27.15 14.01 21 33685 2063 29538758
Blunted affect 27.11 14.01 11 33695 301 29540520
Blood sodium increased 26.99 14.01 23 33683 2591 29538230
Abdominal pain 26.74 14.01 73 33633 135284 29405537
Muscle spasms 26.72 14.01 21 33685 65061 29475760
Anger 26.69 14.01 46 33660 10844 29529977
Sexual dysfunction 26.62 14.01 33 33673 5781 29535040
Thrombosis 26.58 14.01 8 33698 43037 29497784
Patient restraint 26.53 14.01 8 33698 87 29540734
Epistaxis 26.31 14.01 13 33693 51691 29489130
Ascites 26.15 14.01 5 33701 36614 29504207
Flight of ideas 25.89 14.01 11 33695 339 29540482
Cerebellar syndrome 25.60 14.01 20 33686 1994 29538827
Eosinophil count decreased 25.57 14.01 16 33690 1117 29539704
Crying 25.51 14.01 31 33675 5320 29535501
Melaena 25.13 14.01 3 33703 31173 29509648
Headache 24.80 14.01 108 33598 173899 29366922
Coronary artery disease 24.22 14.01 10 33696 44180 29496641
Cogwheel rigidity 24.21 14.01 16 33690 1227 29539594
High-grade B-cell lymphoma 23.83 14.01 7 33699 69 29540752
Metabolic encephalopathy 23.79 14.01 25 33681 3662 29537159
Acute myocardial infarction 23.43 14.01 13 33693 48425 29492396
Infection 23.34 14.01 32 33674 76719 29464102
Cerebral haemorrhage 23.06 14.01 4 33702 31422 29509399
Depressed mood 22.97 14.01 55 33651 16393 29524428
Renal cyst 22.88 14.01 36 33670 7871 29532950
Erythema 22.51 14.01 32 33674 75574 29465247
Drooling 22.25 14.01 22 33684 2999 29537822
Mood altered 22.20 14.01 36 33670 8075 29532746
Haemoptysis 22.18 14.01 4 33702 30546 29510275
Hypersensitivity 21.80 14.01 17 33689 52886 29487935
Metabolic syndrome 21.75 14.01 16 33690 1457 29539364
Angioedema 21.47 14.01 5 33701 31910 29508911
Blood triglycerides increased 21.35 14.01 46 33660 12788 29528033
Mucosal inflammation 21.15 14.01 5 33701 31590 29509231
Otospondylomegaepiphyseal dysplasia 21.04 14.01 7 33699 107 29540714
Poor quality sleep 21.03 14.01 33 33673 7200 29533621
Self-injurious ideation 21.02 14.01 16 33690 1535 29539286
Persistent depressive disorder 20.89 14.01 9 33697 287 29540534
Pleural effusion 20.86 14.01 31 33675 71877 29468944
Urticaria 20.76 14.01 19 33687 54641 29486180
Musculoskeletal pain 20.57 14.01 4 33702 28949 29511872
Restless legs syndrome 20.49 14.01 32 33674 6952 29533869
Hyperkalaemia 20.32 14.01 24 33682 61368 29479453
Dysphemia 19.74 14.01 15 33691 1435 29539386
Intentional product use issue 19.71 14.01 12 33694 42486 29498335
Pneumonitis 19.66 14.01 4 33702 28040 29512781
Cerebrovascular accident 19.66 14.01 36 33670 76875 29463946
Memory impairment 19.60 14.01 88 33618 36382 29504439
Wrong patient received product 19.43 14.01 18 33688 2264 29538557
Agranulocytosis 19.32 14.01 59 33647 20281 29520540
Social anxiety disorder 19.31 14.01 8 33698 231 29540590
Neuropathy peripheral 19.29 14.01 32 33674 70995 29469826
Hepatic failure 19.19 14.01 6 33700 31506 29509315
Haemorrhage 19.19 14.01 14 33692 45058 29495763
Convulsive threshold lowered 19.16 14.01 10 33696 493 29540328
Diabetes mellitus 19.13 14.01 93 33613 39738 29501083
Oxygen saturation decreased 19.08 14.01 14 33692 44923 29495898
Oncocytoma 19.07 14.01 4 33702 7 29540814
Antipsychotic drug level 19.07 14.01 4 33702 7 29540814
Withdrawal syndrome 18.98 14.01 40 33666 10952 29529869
Productive cough 18.95 14.01 6 33700 31253 29509568
Autonomic nervous system imbalance 18.81 14.01 18 33688 2358 29538463
Arthritis 18.77 14.01 3 33703 25016 29515805
Speech sound disorder 18.68 14.01 7 33699 154 29540667
Accidental death 18.60 14.01 17 33689 2101 29538720
Kidney enlargement 18.56 14.01 11 33695 696 29540125
Feelings of worthlessness 18.46 14.01 8 33698 259 29540562
Libido increased 18.36 14.01 11 33695 710 29540111
Altered state of consciousness 18.25 14.01 57 33649 19832 29520989
Blood thyroid stimulating hormone increased 18.18 14.01 20 33686 3085 29537736
Gait disturbance 17.96 14.01 144 33562 73205 29467616
Stomatitis 17.89 14.01 10 33696 37103 29503718
Psychotic symptom 17.88 14.01 14 33692 1400 29539421
Long QT syndrome 17.67 14.01 17 33689 2241 29538580
Secondary tic 17.58 14.01 4 33702 12 29540809
Hallucination, olfactory 17.51 14.01 7 33699 184 29540637
Depressive symptom 17.51 14.01 15 33691 1702 29539119
Chest discomfort 17.44 14.01 16 33690 45967 29494854
Abdominal distension 17.39 14.01 16 33690 45895 29494926
Weight decreased 17.30 14.01 101 33605 150804 29390017
Anaphylactic reaction 17.24 14.01 5 33701 27568 29513253
Bone marrow failure 17.13 14.01 5 33701 27444 29513377
Staphylococcal infection 17.05 14.01 6 33700 29234 29511587
Oromandibular dystonia 16.89 14.01 9 33697 463 29540358
Dysphoria 16.85 14.01 16 33690 2076 29538745
Urinary incontinence 16.78 14.01 49 33657 16432 29524389
Electroconvulsive therapy 16.69 14.01 4 33702 16 29540805
Hypoaesthesia 16.55 14.01 22 33684 53445 29487376
Cerebral infarction 16.33 14.01 4 33702 24671 29516150
Thought blocking 16.31 14.01 6 33700 125 29540696
Drug withdrawal syndrome 16.00 14.01 51 33655 17933 29522888
Dyspnoea exertional 15.97 14.01 11 33695 36479 29504342
Impulsive behaviour 15.91 14.01 15 33691 1928 29538893
Acarodermatitis 15.82 14.01 8 33698 369 29540452
Toxic cardiomyopathy 15.78 14.01 7 33699 240 29540581
Drug hypersensitivity 15.78 14.01 34 33672 68372 29472449
Angina pectoris 15.76 14.01 6 33700 27844 29512977
Inappropriate affect 15.68 14.01 9 33697 536 29540285
Gastrectomy 15.64 14.01 6 33700 141 29540680
Intentional self-injury 15.63 14.01 40 33666 12421 29528400
Upper gastrointestinal haemorrhage 15.63 14.01 3 33703 21911 29518910
Prostate cancer 15.30 14.01 5 33701 25522 29515299
Encephalopathy 15.28 14.01 73 33633 30970 29509851
Arthropathy 15.26 14.01 3 33703 21551 29519270
Nephrolithiasis 15.11 14.01 5 33701 25329 29515492
Diabetic coma 15.09 14.01 10 33696 770 29540051
International normalised ratio increased 15.06 14.01 17 33689 44355 29496466
Metastases to eye 14.99 14.01 5 33701 77 29540744
Balance disorder 14.96 14.01 81 33625 36089 29504732
Paradoxical drug reaction 14.93 14.01 17 33689 2724 29538097
Stupor 14.91 14.01 17 33689 2727 29538094
Haematoma 14.91 14.01 4 33702 23208 29517613
Hyperhidrosis 14.88 14.01 125 33581 64415 29476406
Multiple organ dysfunction syndrome 14.86 14.01 31 33675 63085 29477736
Hypertonia 14.82 14.01 20 33686 3809 29537012
Major depression 14.79 14.01 20 33686 3815 29537006
Muscle twitching 14.79 14.01 30 33676 7996 29532825
Herpes zoster 14.63 14.01 8 33698 30044 29510777
Post-traumatic stress disorder 14.21 14.01 13 33693 1609 29539212
Coma 14.12 14.01 85 33621 39365 29501456

FDA Adverse Event Reporting System (Geriatric)

MedDRA adverse event termLikelihood ratioLikelihood ratio thresholdPatients taking drug having adverse eventPatients taking drug not having adverse eventPatients not taking drug having adverse eventPatients not taking drug not having adverse event
Toxicity to various agents 1754.33 13.13 1954 61028 361559 64074191
Neuroleptic malignant syndrome 1039.08 13.13 501 62481 24495 64411255
Tremor 914.29 13.13 911 62071 147319 64288431
Nephrogenic diabetes insipidus 901.80 13.13 234 62748 1653 64434097
Mania 721.04 13.13 341 62641 15945 64419805
Drug interaction 608.50 13.13 1186 61796 360897 64074853
Antipsychotic drug level increased 543.28 13.13 200 62782 4915 64430835
Extrapyramidal disorder 456.92 13.13 267 62715 19285 64416465
Hypomania 452.95 13.13 180 62802 5474 64430276
Psychotic disorder 429.56 13.13 318 62664 34260 64401490
Completed suicide 394.17 13.13 750 62232 223664 64212086
Hyperparathyroidism 372.54 13.13 130 62852 2722 64433028
Schizophrenia 347.07 13.13 184 62798 10984 64424766
Ataxia 345.84 13.13 234 62748 21850 64413900
Serotonin syndrome 343.64 13.13 294 62688 38988 64396762
Agitation 336.62 13.13 423 62559 87944 64347806
Antipsychotic drug level above therapeutic 318.80 13.13 104 62878 1757 64433993
Akathisia 311.41 13.13 173 62809 11337 64424413
Parkinsonism 296.06 13.13 181 62801 14192 64421558
Sedation 290.85 13.13 274 62708 41188 64394562
Suicidal ideation 289.91 13.13 341 62641 66201 64369549
Suicide attempt 283.36 13.13 348 62634 70659 64365091
Tardive dyskinesia 270.54 13.13 146 62836 9032 64426718
Granulocytopenia 234.48 13.13 139 62843 10301 64425449
Diabetes insipidus 232.24 13.13 105 62877 4416 64431334
Dysarthria 230.31 13.13 287 62695 59119 64376631
Aggression 230.27 13.13 254 62728 45978 64389772
Catatonia 226.78 13.13 122 62860 7498 64428252
Dyspnoea 215.86 13.13 231 62751 718443 63717307
Bipolar disorder 214.61 13.13 113 62869 6648 64429102
Pain 211.31 13.13 141 62841 553370 63882380
Salivary hypersecretion 210.53 13.13 137 62845 11976 64423774
Hypernatraemia 209.75 13.13 137 62845 12052 64423698
Obsessive-compulsive disorder 204.34 13.13 98 62884 4720 64431030
Confusional state 203.26 13.13 638 62344 260506 64175244
Irritability 197.17 13.13 210 62772 36536 64399214
Psychomotor hyperactivity 193.20 13.13 139 62843 14312 64421438
Delirium 188.85 13.13 282 62700 68912 64366838
Arthralgia 187.92 13.13 99 62883 442161 63993589
Muscle rigidity 186.77 13.13 147 62835 17326 64418424
Hallucination, auditory 179.97 13.13 142 62840 16797 64418953
Myoclonus 162.86 13.13 159 62823 24959 64410791
Mental status changes 162.24 13.13 246 62736 60916 64374834
Delusion 161.91 13.13 137 62845 17877 64417873
Overdose 150.85 13.13 418 62564 159148 64276602
Disorientation 147.29 13.13 224 62758 55604 64380146
Drug level increased 146.78 13.13 174 62808 34022 64401728
Neurotoxicity 145.92 13.13 156 62826 27248 64408502
Hypothyroidism 137.22 13.13 183 62799 40274 64395476
Weight increased 137.19 13.13 489 62493 212859 64222891
Hyperreflexia 137.00 13.13 86 62896 7062 64428688
Antipsychotic drug level below therapeutic 136.76 13.13 47 62935 938 64434812
Polyuria 134.33 13.13 106 62876 12537 64423213
Dystonia 132.86 13.13 125 62857 18740 64417010
Abnormal behaviour 131.15 13.13 163 62819 33459 64402291
Intentional overdose 128.13 13.13 276 62706 89668 64346082
Somnolence 126.87 13.13 462 62520 203183 64232567
Rheumatoid arthritis 122.86 13.13 10 62972 164284 64271466
Dyskinesia 119.76 13.13 169 62813 39219 64396531
Febrile neutropenia 116.96 13.13 21 62961 187636 64248114
Cough 114.99 13.13 77 62905 302071 64133679
Anaemia 114.10 13.13 121 62861 378559 64057191
Pleurothotonus 110.48 13.13 51 62931 2251 64433499
Infusion related reaction 110.21 13.13 15 62967 164452 64271298
Polydipsia 108.97 13.13 69 62913 5752 64429998
Schizoaffective disorder 108.15 13.13 45 62937 1542 64434208
Brugada syndrome 106.57 13.13 40 62942 1038 64434712
Disturbance in attention 105.78 13.13 163 62819 40911 64394839
Pain in extremity 101.57 13.13 88 62894 302997 64132753
Bruxism 99.46 13.13 55 62927 3569 64432181
Joint swelling 97.70 13.13 44 62938 215338 64220412
Pruritus 97.26 13.13 97 62885 312303 64123447
Nephropathy 97.12 13.13 74 62908 8312 64427438
Euphoric mood 96.43 13.13 67 62915 6524 64429226
Restlessness 95.68 13.13 153 62829 39632 64396118
Depressed level of consciousness 95.04 13.13 231 62751 81205 64354545
Cognitive disorder 94.98 13.13 183 62799 54904 64380846
Treatment noncompliance 92.19 13.13 158 62824 43324 64392426
Hypersensitivity 90.89 13.13 39 62943 196413 64239337
Malignant neoplasm progression 89.84 13.13 5 62977 112866 64322884
Intentional self-injury 88.85 13.13 125 62857 28919 64406831
Jaundice cholestatic 88.49 13.13 71 62911 8599 64427151
Apathy 87.99 13.13 79 62903 11153 64424597
Peripheral swelling 86.92 13.13 48 62934 209105 64226645
Depression 86.16 13.13 381 62601 182910 64252840
Swelling 85.74 13.13 25 62957 160193 64275557
Nasopharyngitis 84.42 13.13 43 62939 196030 64239720
Priapism 84.31 13.13 51 62931 3919 64431831
Synovitis 83.41 13.13 3 62979 99087 64336663
Back pain 83.35 13.13 73 62909 250098 64185652
Grandiosity 82.51 13.13 28 62954 537 64435213
Disease progression 81.74 13.13 19 62963 141661 64294089
Arthropathy 81.10 13.13 11 62971 120956 64314794
Libido increased 80.77 13.13 38 62944 1752 64433998
Renal cyst 80.40 13.13 79 62903 12491 64423259
Rash 79.98 13.13 209 62773 458340 63977410
Interstitial lung disease 78.81 13.13 4 62978 97728 64338022
Oppositional defiant disorder 78.57 13.13 26 62956 460 64435290
Mental disorder 78.21 13.13 112 62870 26333 64409417
Logorrhoea 78.20 13.13 49 62933 4010 64431740
Clonus 77.99 13.13 57 62925 6010 64429740
Affect lability 77.98 13.13 67 62915 8923 64426827
White blood cell count increased 77.81 13.13 188 62794 65826 64369924
Cogwheel rigidity 77.47 13.13 43 62939 2810 64432940
Leukocytosis 77.21 13.13 135 62847 37605 64398145
Anxiety 76.92 13.13 396 62586 202253 64233497
Speech disorder 76.36 13.13 155 62827 48286 64387464
Electrocardiogram QT prolonged 75.84 13.13 209 62773 79239 64356511
Neutrophil count increased 75.01 13.13 107 62875 25067 64410683
Homicidal ideation 74.79 13.13 44 62938 3213 64432537
Coordination abnormal 74.09 13.13 82 62900 14882 64420868
Parathyroid tumour benign 73.25 13.13 27 62955 665 64435085
Choreoathetosis 72.40 13.13 33 62949 1414 64434336
Sinusitis 72.37 13.13 26 62956 145902 64289848
Depressed mood 71.62 13.13 137 62845 40875 64394875
Fatigue 71.48 13.13 434 62548 748296 63687454
Mutism 70.30 13.13 36 62946 1998 64433752
Atrial fibrillation 70.01 13.13 40 62942 171049 64264701
Paranoia 69.81 13.13 83 62899 16269 64419481
Body tinea 69.50 13.13 31 62951 1262 64434488
Stomatitis 68.84 13.13 12 62970 109593 64326157
Insomnia 68.52 13.13 377 62605 197459 64238291
Decreased eye contact 67.05 13.13 26 62956 739 64435011
Thinking abnormal 65.45 13.13 68 62914 11488 64424262
Cardiac failure congestive 65.20 13.13 23 62959 130557 64305193
Chronic kidney disease 65.13 13.13 162 62820 57757 64377993
Blood creatine phosphokinase increased 65.02 13.13 163 62819 58395 64377355
Death 63.85 13.13 249 62733 482456 63953294
Hypercalcaemia 63.77 13.13 112 62870 31304 64404446
Systemic lupus erythematosus 63.14 13.13 3 62979 77609 64358141
Drug level above therapeutic 63.06 13.13 53 62929 6848 64428902
Abdominal pain 62.70 13.13 132 62850 312243 64123507
Sopor 61.84 13.13 107 62875 29554 64406196
Pneumonia 61.15 13.13 310 62672 559266 63876484
Poisoning 60.83 13.13 90 62892 21789 64413961
Arthritis 60.21 13.13 6 62976 83808 64351942
Altered state of consciousness 59.40 13.13 121 62861 37781 64397969
Alopecia 59.32 13.13 45 62937 165645 64270105
Hyperparathyroidism primary 59.31 13.13 20 62962 376 64435374
Camptocormia 59.28 13.13 21 62961 460 64435290
Hostility 59.21 13.13 33 62949 2174 64433576
Diarrhoea 58.88 13.13 439 62543 722265 63713485
Poor quality sleep 58.61 13.13 82 62900 18869 64416881
Headache 58.60 13.13 292 62690 529175 63906575
Gastrointestinal haemorrhage 58.47 13.13 28 62954 132284 64303466
Leukopenia 58.20 13.13 224 62758 101018 64334732
Myocarditis 57.63 13.13 77 62905 16966 64418784
Aphasia 57.61 13.13 125 62857 40781 64394969
Drooling 57.37 13.13 45 62937 5274 64430476
Infection 56.80 13.13 58 62924 184822 64250928
Hyperprolactinaemia 56.39 13.13 40 62942 4025 64431725
Anticholinergic syndrome 55.94 13.13 34 62948 2635 64433115
Urticaria 55.36 13.13 38 62944 147279 64288471
Enuresis 54.55 13.13 34 62948 2756 64432994
Bipolar I disorder 54.50 13.13 29 62953 1742 64434008
Pressure of speech 53.80 13.13 24 62958 977 64434773
Sepsis 52.63 13.13 90 62892 230251 64205499
Stupor 52.39 13.13 45 62937 5990 64429760
Delusion of grandeur 51.20 13.13 20 62962 580 64435170
Increased appetite 50.92 13.13 56 62926 10090 64425660
Lethargy 50.55 13.13 171 62811 72423 64363327
Dystonic tremor 50.54 13.13 15 62967 182 64435568
Contraindicated product administered 50.49 13.13 21 62961 107808 64327942
General physical health deterioration 50.35 13.13 76 62906 204349 64231401
Distractibility 49.76 13.13 20 62962 626 64435124
Thrombocytopenia 48.83 13.13 90 62892 223711 64212039
Septic shock 48.63 13.13 21 62961 105416 64330334
Injection site erythema 48.50 13.13 6 62976 70794 64364956
Drug intolerance 48.15 13.13 68 62914 187924 64247826
Infection susceptibility increased 47.77 13.13 31 62951 2695 64433055
Blood sodium increased 47.53 13.13 37 62945 4289 64431461
Cerebellar syndrome 46.82 13.13 39 62943 4977 64430773
Encephalopathy 46.78 13.13 145 62837 58674 64377076
Withdrawal syndrome 46.70 13.13 83 62899 23409 64412341
Inhibitory drug interaction 46.45 13.13 34 62948 3593 64432157
Abdominal pain upper 46.14 13.13 62 62920 174968 64260782
Trismus 45.53 13.13 38 62944 4863 64430887
Glossodynia 45.52 13.13 5 62977 64691 64371059
Mental impairment 45.10 13.13 67 62915 16276 64419474
Postural tremor 44.80 13.13 18 62964 563 64435187
Personality disorder 44.75 13.13 37 62945 4674 64431076
Wound 44.61 13.13 10 62972 76467 64359283
Depressive symptom 44.15 13.13 36 62946 4460 64431290
Bronchitis 43.65 13.13 26 62956 108717 64327033
Action tremor 43.56 13.13 16 62966 390 64435360
Myocardial infarction 43.44 13.13 59 62923 165762 64269988
Renal oncocytoma 43.37 13.13 11 62971 70 64435680
Neuropathy peripheral 43.24 13.13 31 62951 117494 64318256
Memory impairment 43.19 13.13 182 62800 85500 64350250
Blood prolactin increased 42.77 13.13 32 62950 3496 64432254
Blunted affect 42.74 13.13 16 62966 412 64435338
Anger 42.68 13.13 64 62918 15677 64420073
Intentional product use issue 42.40 13.13 20 62962 95344 64340406
Glucose tolerance impaired 42.15 13.13 41 62941 6402 64429348
Electrocardiogram T wave abnormal 41.94 13.13 31 62951 3325 64432425
Decreased appetite 41.83 13.13 138 62844 281151 64154599
Bradykinesia 41.53 13.13 41 62941 6519 64429231
Chest pain 41.47 13.13 107 62875 235873 64199877
Pericarditis 41.15 13.13 6 62976 62510 64373240
Ascites 40.70 13.13 6 62976 61995 64373755
Disinhibition 40.52 13.13 26 62956 2217 64433533
Abulia 40.46 13.13 19 62963 872 64434878
Resting tremor 40.29 13.13 22 62960 1392 64434358
Muscle twitching 40.21 13.13 69 62913 18929 64416821
Cerebellar atrophy 40.12 13.13 20 62962 1048 64434702
Failure to suspend medication 39.93 13.13 15 62967 390 64435360
Drug reaction with eosinophilia and systemic symptoms 39.77 13.13 130 62852 54087 64381663
Pancytopenia 39.59 13.13 49 62933 143260 64292490
Cardio-respiratory arrest 39.18 13.13 195 62787 98198 64337552
Abdominal discomfort 39.16 13.13 74 62908 182248 64253502
Visuospatial deficit 38.94 13.13 9 62973 36 64435714
Oxygen saturation decreased 38.48 13.13 29 62953 107147 64328603
Soft tissue injury 38.02 13.13 22 62960 1557 64434193
Schizoaffective disorder bipolar type 37.80 13.13 11 62971 124 64435626
Oculogyric crisis 37.60 13.13 26 62956 2512 64433238
Blister 37.53 13.13 16 62966 80951 64354799
Electrocardiogram T wave inversion 37.50 13.13 34 62948 4860 64430890
Impaired healing 37.15 13.13 7 62975 60466 64375284
Hyperthyroidism 37.13 13.13 65 62917 18114 64417636
Metabolic syndrome 37.03 13.13 25 62957 2323 64433427
Asterixis 36.88 13.13 25 62957 2338 64433412
Mucosal inflammation 36.87 13.13 8 62974 62576 64373174
Cardiac failure 36.83 13.13 45 62937 132328 64303422
Electroconvulsive therapy 36.59 13.13 10 62972 88 64435662
Muscle contractions involuntary 36.40 13.13 28 62954 3189 64432561
Galactorrhoea 36.38 13.13 28 62954 3191 64432559
Productive cough 36.35 13.13 13 62969 73190 64362560
Musculoskeletal pain 36.22 13.13 17 62965 81277 64354473
Haemodialysis 36.11 13.13 62 62920 17015 64418735
Thrombosis 36.02 13.13 12 62970 70630 64365120
Psychiatric decompensation 35.94 13.13 25 62957 2438 64433312
Sleep-related eating disorder 35.53 13.13 16 62966 666 64435084
Pneumonitis 35.16 13.13 4 62978 50361 64385389
Goitre 35.10 13.13 33 62949 4940 64430810
Mood altered 35.09 13.13 59 62923 15920 64419830
Electrocardiogram QRS complex prolonged 34.73 13.13 44 62938 9200 64426550
International normalised ratio increased 34.59 13.13 17 62965 79150 64356600
Self-injurious ideation 34.38 13.13 27 62955 3170 64432580
Gait disturbance 34.20 13.13 286 62696 171869 64263881
Persecutory delusion 34.06 13.13 30 62952 4128 64431622
Asthma 33.89 13.13 26 62956 95199 64340551
Haemoglobin decreased 33.84 13.13 89 62893 194974 64240776
Electroencephalogram abnormal 33.83 13.13 33 62949 5170 64430580
Blood thyroid stimulating hormone decreased 33.69 13.13 33 62949 5197 64430553
Respiratory arrest 33.58 13.13 121 62861 52864 64382886
Melaena 33.32 13.13 6 62976 53542 64382208
Malaise 32.96 13.13 239 62743 396008 64039742
Hyperkinesia 32.91 13.13 24 62958 2522 64433228
Dysphemia 32.80 13.13 26 62956 3093 64432657
Anaphylactic reaction 32.75 13.13 13 62969 68651 64367099
Feeling guilty 32.66 13.13 16 62966 807 64434943
Acute psychosis 32.61 13.13 28 62954 3724 64432026
Electrocardiogram abnormal 32.61 13.13 52 62930 13429 64422321
Gastrointestinal disorder 32.56 13.13 24 62958 89685 64346065
Nodal rhythm 32.49 13.13 25 62957 2849 64432901
Major depression 32.26 13.13 39 62943 7777 64427973
Epistaxis 32.20 13.13 29 62953 98102 64337648
Psychiatric symptom 32.13 13.13 35 62947 6238 64429512
Impulsive behaviour 31.94 13.13 24 62958 2639 64433111
Hypertonia 31.90 13.13 35 62947 6290 64429460
Haemorrhage 31.81 13.13 19 62963 79332 64356418
Post-traumatic neck syndrome 31.79 13.13 21 62961 1881 64433869
Social avoidant behaviour 31.71 13.13 30 62952 4527 64431223
Oedema peripheral 31.38 13.13 103 62879 210214 64225536
Plasma cell myeloma 31.32 13.13 4 62978 46071 64389679
Therapeutic product effect decreased 31.27 13.13 40 62942 115311 64320439
Speech sound disorder 31.26 13.13 8 62974 53 64435697
Erythema 31.21 13.13 87 62895 186983 64248767
Cerebrovascular accident 31.18 13.13 54 62928 137529 64298221
Tachycardia 31.05 13.13 251 62731 149328 64286422
Affective disorder 30.76 13.13 35 62947 6545 64429205
Feelings of worthlessness 30.51 13.13 13 62969 473 64435277
Echolalia 30.49 13.13 12 62970 355 64435395
Oncocytoma 30.49 13.13 7 62975 27 64435723
Papillary thyroid cancer 30.47 13.13 22 62960 2276 64433474
Pleural effusion 30.23 13.13 48 62934 126511 64309239
Osteoarthritis 30.19 13.13 12 62970 63324 64372426
Injection site pain 29.82 13.13 39 62943 111369 64324381
Lung disorder 29.76 13.13 11 62971 60689 64375061
Urinary incontinence 29.56 13.13 90 62892 36061 64399689
Impaired quality of life 29.54 13.13 34 62948 6437 64429313
Drug withdrawal syndrome 29.53 13.13 82 62900 31209 64404541
Hallucination 29.50 13.13 145 62837 72643 64363107
Adams-Stokes syndrome 28.95 13.13 9 62973 129 64435621
Acute myocardial infarction 28.93 13.13 16 62966 69702 64366048
Seizure 28.87 13.13 269 62713 166623 64269127
Dysphoria 28.85 13.13 28 62954 4360 64431390
Sternal fracture 28.63 13.13 21 62961 2226 64433524
Otospondylomegaepiphyseal dysplasia 28.54 13.13 7 62975 38 64435712
Nausea 28.49 13.13 569 62413 785231 63650519
Convulsive threshold lowered 28.45 13.13 15 62967 884 64434866
Agranulocytosis 28.34 13.13 92 62890 38137 64397613
Bradyphrenia 28.05 13.13 40 62942 9366 64426384
Obesity 28.00 13.13 62 62920 20500 64415250
Neurological symptom 27.92 13.13 34 62948 6830 64428920
Sleep disorder 27.91 13.13 124 62858 59585 64376165
Blood pressure fluctuation 27.90 13.13 8 62974 51863 64383887
Dyspnoea exertional 27.71 13.13 19 62963 73711 64362039
Rhinorrhoea 27.56 13.13 12 62970 59957 64375793
Drug hypersensitivity 27.47 13.13 129 62853 237686 64198064
Tachyphrenia 27.28 13.13 19 62963 1857 64433893
Patient restraint 26.96 13.13 8 62974 97 64435653
Hypoxia 26.66 13.13 28 62954 88121 64347629
Psoriatic arthropathy 26.60 13.13 5 62977 43276 64392474
Cardiac hypertrophy 26.45 13.13 17 62965 1454 64434296
Parkinsonian gait 26.40 13.13 14 62968 835 64434915
Acquired cystic kidney disease 26.31 13.13 7 62975 55 64435695
Muscle spasms 26.28 13.13 62 62920 140961 64294789
Gaze palsy 26.27 13.13 21 62961 2529 64433221
Restless legs syndrome 26.05 13.13 54 62928 17062 64418688
Weight decreased 25.89 13.13 168 62814 285571 64150179
Osteonecrosis of jaw 25.80 13.13 4 62978 39821 64395929
Hereditary ataxia 25.58 13.13 6 62976 26 64435724
Hyporeflexia 25.41 13.13 23 62959 3281 64432469
Neutrophilia 25.37 13.13 32 62950 6662 64429088
Paraesthesia 25.18 13.13 59 62923 134463 64301287
Mobility decreased 25.15 13.13 28 62954 85812 64349938
Skin ulcer 25.14 13.13 6 62976 43968 64391782
Flat affect 25.13 13.13 18 62964 1839 64433911
Prescribed overdose 25.13 13.13 59 62923 20272 64415478
Antipsychotic drug level decreased 25.01 13.13 14 62968 930 64434820
Hypothermia 24.95 13.13 58 62924 19798 64415952
Injection site swelling 24.95 13.13 5 62977 41348 64394402
Coronary artery disease 24.89 13.13 14 62968 60419 64375331
Cholelithiasis 24.77 13.13 99 62883 45407 64390343
Sinus arrest 24.73 13.13 22 62960 3068 64432682
Neoplasm progression 24.61 13.13 5 62977 40959 64394791
Sluggishness 24.56 13.13 29 62953 5641 64430109
Fibromyalgia 24.54 13.13 3 62979 35728 64400022
Balance disorder 24.51 13.13 153 62829 83773 64351977
Hyperhidrosis 24.51 13.13 207 62775 124713 64311037
Hyperkalaemia 24.49 13.13 38 62944 101091 64334659
Bone pain 24.39 13.13 8 62974 47564 64388186
Hepatotoxicity 24.25 13.13 90 62892 39872 64395878
High-grade B-cell lymphoma 24.13 13.13 7 62975 78 64435672
Substance abuse 24.09 13.13 37 62945 9255 64426495
Upper gastrointestinal haemorrhage 24.08 13.13 3 62979 35217 64400533
Hypokalaemia 24.01 13.13 52 62930 121851 64313899
Bundle branch block right 24.01 13.13 39 62943 10230 64425520
Influenza 23.96 13.13 42 62940 106489 64329261
Haemoptysis 23.86 13.13 9 62973 49039 64386711
Cerebral haemorrhage 23.83 13.13 10 62972 51080 64384670
Metabolic encephalopathy 23.74 13.13 34 62948 7991 64427759
Antidepressant drug level increased 23.57 13.13 10 62972 360 64435390
Long QT syndrome 23.46 13.13 27 62955 5112 64430638
Haematoma 23.33 13.13 8 62974 46242 64389508
Platelet count decreased 23.07 13.13 85 62897 167626 64268124
Blood creatinine increased 23.05 13.13 218 62764 135564 64300186
Mood swings 23.03 13.13 52 62930 17416 64418334
Nephropathy toxic 22.94 13.13 52 62930 17462 64418288
Flight of ideas 22.89 13.13 12 62970 699 64435051
Treatment failure 22.86 13.13 50 62932 116766 64318984
Antipsychotic drug level 22.75 13.13 5 62977 15 64435735
Status epilepticus 22.68 13.13 59 62923 21604 64414146
Clear cell renal cell carcinoma 22.57 13.13 18 62964 2161 64433589
Hepatocellular injury 22.51 13.13 8 62974 45227 64390523
Chest discomfort 22.47 13.13 50 62932 116056 64319694
Hyperthermia 22.44 13.13 48 62934 15502 64420248
Angina pectoris 22.39 13.13 8 62974 45073 64390677
Abdominal distension 22.37 13.13 37 62945 95957 64339793
Hyperammonaemia 22.32 13.13 37 62945 9867 64425883
Negativism 22.14 13.13 12 62970 748 64435002
Thought blocking 21.98 13.13 8 62974 190 64435560
Nystagmus 21.96 13.13 35 62947 9033 64426717
Staphylococcal infection 21.96 13.13 11 62971 50667 64385083
Suspected suicide 21.79 13.13 34 62948 8620 64427130
Thyroiditis 21.74 13.13 22 62960 3602 64432148
Drug abuse 21.71 13.13 211 62771 132163 64303587
Hallucination, olfactory 21.58 13.13 10 62972 445 64435305
Sexual dysfunction 21.51 13.13 29 62953 6442 64429308
Product use issue 21.46 13.13 76 62906 151639 64284111
Autonomic nervous system imbalance 21.07 13.13 23 62959 4109 64431641
Upper respiratory tract infection 21.04 13.13 24 62958 72761 64362989
Chronic obstructive pulmonary disease 21.00 13.13 23 62959 71025 64364725
Drug level decreased 20.78 13.13 39 62943 11464 64424286
Injection site bruising 20.72 13.13 5 62977 36368 64399382
Sleep apnoea syndrome 20.51 13.13 70 62912 29762 64405988
Cystitis 20.48 13.13 8 62974 42667 64393083
Thyrotoxic crisis 20.32 13.13 13 62969 1103 64434647
Delusion of reference 20.22 13.13 7 62975 143 64435607
Therapeutic product effect variable 20.13 13.13 15 62967 1629 64434121
Eosinophilia 20.05 13.13 82 62900 37994 64397756
Discomfort 19.96 13.13 30 62952 80848 64354902
Lactate pyruvate ratio increased 19.77 13.13 6 62976 79 64435671
Hallucination, visual 19.75 13.13 66 62916 27768 64407982
Ideas of reference 19.73 13.13 7 62975 154 64435596
Impaired work ability 19.72 13.13 45 62937 15174 64420576
Blood pressure increased 19.68 13.13 94 62888 172458 64263292
Blood thyroid stimulating hormone increased 19.17 13.13 30 62952 7624 64428126
Diverticulitis 18.93 13.13 7 62975 38611 64397139
Lower respiratory tract infection 18.93 13.13 40 62942 94574 64341176
Cerebral atrophy 18.87 13.13 29 62953 7256 64428494
Differential white blood cell count abnormal 18.85 13.13 15 62967 1795 64433955
Muscle contracture 18.63 13.13 16 62966 2129 64433621
Social anxiety disorder 18.62 13.13 9 62973 441 64435309
Hallucinations, mixed 18.43 13.13 26 62956 6026 64429724
Myalgia 18.33 13.13 86 62896 158531 64277219
Histrionic personality disorder 18.29 13.13 5 62977 44 64435706
Behaviour disorder 17.98 13.13 22 62960 4440 64431310
Fluid retention 17.95 13.13 19 62963 59587 64376163
Osteonecrosis 17.92 13.13 3 62979 28226 64407524
Limbic encephalitis 17.91 13.13 10 62972 661 64435089
Atrioventricular block first degree 17.69 13.13 35 62947 10699 64425051
Merycism 17.60 13.13 7 62975 213 64435537
Eosinophil count decreased 17.58 13.13 17 62965 2635 64433115
Intention tremor 17.57 13.13 10 62972 686 64435064
Hypoaesthesia 17.54 13.13 73 62909 139035 64296715
Secondary tic 17.51 13.13 4 62978 15 64435735
Localised infection 17.47 13.13 4 62978 30157 64405593
Pyrexia 17.44 13.13 414 62568 558230 63877520
Haematuria 17.41 13.13 20 62962 60451 64375299
Inflammation 17.33 13.13 23 62959 65277 64370473
Ileus paralytic 17.07 13.13 30 62952 8385 64427365
Bone density decreased 17.07 13.13 33 62949 9919 64425831
Femur fracture 17.05 13.13 6 62976 34129 64401621
Wheezing 17.03 13.13 33 62949 80546 64355204
Staring 17.02 13.13 16 62966 2394 64433356
Haematochezia 16.98 13.13 24 62958 66349 64369401
Blood citric acid increased 16.97 13.13 5 62977 59 64435691
Autoimmune thyroiditis 16.89 13.13 19 62963 3509 64432241
Antidepressant drug level above therapeutic 16.88 13.13 9 62973 543 64435207
Gastric disorder 16.66 13.13 4 62978 29193 64406557
Coma 16.56 13.13 144 62838 87471 64348279
Torticollis 16.44 13.13 15 62967 2162 64433588
Maternal exposure during pregnancy 16.42 13.13 44 62938 95840 64339910
Urine output increased 16.40 13.13 14 62968 1847 64433903
Metabolic disorder 16.34 13.13 28 62954 7669 64428081
Hepatic failure 16.30 13.13 18 62964 55376 64380374
Colitis 16.26 13.13 20 62962 58654 64377096
Activation syndrome 16.19 13.13 7 62975 264 64435486
Gambling disorder 16.19 13.13 14 62968 1880 64433870
Rectal haemorrhage 16.17 13.13 22 62960 61795 64373955
Basal cell carcinoma 16.14 13.13 5 62977 30833 64404917
Decreased interest 15.92 13.13 18 62964 3342 64432408
Throat irritation 15.91 13.13 6 62976 32705 64403045
Tic 15.90 13.13 16 62966 2603 64433147
Oropharyngeal pain 15.82 13.13 40 62942 88827 64346923
Unmasking of previously unidentified disease 15.78 13.13 13 62969 1634 64434116
Dry skin 15.75 13.13 16 62966 51145 64384605
Fungal infection 15.50 13.13 7 62975 34244 64401506
Diabetic coma 15.39 13.13 11 62971 1120 64434630
Fluid intake reduced 15.34 13.13 22 62960 5178 64430572
Full blood count abnormal 15.26 13.13 5 62977 29752 64405998
Oscillopsia 15.23 13.13 6 62976 178 64435572
Peritonitis 15.15 13.13 3 62979 25020 64410730
Parasomnia 14.94 13.13 8 62974 487 64435263
Cerebellar ataxia 14.88 13.13 13 62969 1770 64433980
Hypersexuality 14.85 13.13 12 62970 1467 64434283
Knee arthroplasty 14.83 13.13 4 62978 26995 64408755
Bacteraemia 14.75 13.13 4 62978 26907 64408843
Psychotic symptom 14.73 13.13 14 62968 2124 64433626
Refusal of treatment by patient 14.73 13.13 28 62954 8311 64427439
Apraxia 14.70 13.13 15 62967 2480 64433270
Diabetic hyperosmolar coma 14.70 13.13 9 62973 707 64435043
Dry eye 14.67 13.13 5 62977 29014 64406736
Pain in jaw 14.66 13.13 11 62971 40744 64395006
Blood pressure systolic increased 14.62 13.13 16 62966 49437 64386313
Movement disorder 14.58 13.13 51 62931 21949 64413801
Blood triglycerides increased 14.52 13.13 46 62936 18820 64416930
Injection site haemorrhage 14.51 13.13 3 62979 24275 64411475
Concussion 14.45 13.13 27 62955 7911 64427839
Middle insomnia 14.45 13.13 36 62946 12841 64422909
Cyclothymic disorder 14.38 13.13 6 62976 207 64435543
Respiratory distress 14.33 13.13 18 62964 52313 64383437
Mydriasis 14.32 13.13 40 62942 15272 64420478
Water intoxication 14.31 13.13 9 62973 741 64435009
Device related infection 14.27 13.13 6 62976 30620 64405130
Angioedema 14.24 13.13 24 62958 61797 64373953
Toxic cardiomyopathy 14.22 13.13 7 62975 357 64435393
Myelosuppression 14.13 13.13 3 62979 23827 64411923
Mouth ulceration 14.12 13.13 7 62975 32437 64403313
Eye movement disorder 14.05 13.13 25 62957 7054 64428696
Jaundice 14.01 13.13 16 62966 48496 64387254
Persistent depressive disorder 14.01 13.13 10 62972 1016 64434734
Incoherent 13.95 13.13 25 62957 7093 64428657
Essential tremor 13.88 13.13 11 62971 1308 64434442
Impaired self-care 13.80 13.13 14 62968 2299 64433451
Ear infection 13.77 13.13 3 62979 23401 64412349
Dialysis 13.71 13.13 42 62940 16878 64418872
Burning sensation 13.68 13.13 17 62965 49647 64386103
Dysphagia 13.66 13.13 162 62820 106650 64329100
Cerebral infarction 13.61 13.13 12 62970 41032 64394718
Judgement impaired 13.61 13.13 10 62972 1063 64434687
Tooth injury 13.56 13.13 11 62971 1352 64434398
Epileptic encephalopathy 13.43 13.13 7 62975 403 64435347
Acute myeloid leukaemia 13.42 13.13 5 62977 27458 64408292
Potentiating drug interaction 13.42 13.13 26 62956 7826 64427924
Hypoglycaemia 13.41 13.13 44 62938 89848 64345902
Stereotypy 13.36 13.13 9 62973 833 64434917
Hyperammonaemic encephalopathy 13.21 13.13 18 62964 4040 64431710
Intercepted product prescribing error 13.19 13.13 6 62976 256 64435494
Benign ethnic neutropenia 13.16 13.13 4 62978 53 64435697
Hip fracture 13.13 13.13 5 62977 27094 64408656

FDA Adverse Event Reporting System (Pediatric)

None

Pharmacologic Action:

SourceCodeDescription
ATC N05AN01 NERVOUS SYSTEM
PSYCHOLEPTICS
ANTIPSYCHOTICS
Lithium
CHEBI has role CHEBI:35469 antidepressants
MeSH PA D000928 Antidepressive Agents
MeSH PA D018692 Antimanic Agents
MeSH PA D002491 Central Nervous System Agents
MeSH PA D002492 Central Nervous System Depressants
MeSH PA D004791 Enzyme Inhibitors
MeSH PA D011619 Psychotropic Drugs
MeSH PA D014149 Tranquilizing Agents

Drug Use (View source of the data)

DiseaseRelationSNOMED_IDDOID
Bipolar disorder indication 13746004 DOID:3312
Bipolar disorder in remission indication 85248005
Bipolar affective disorder, current episode manic indication 191618007
Vascular headache off-label use 128187005
Bipolar affective disorder, current episode depression off-label use 191627008 DOID:3312
Cluster Headache Prevention off-label use
Rapid Cycling Bipolar Affective Disorder off-label use
Psoriasis contraindication 9014002 DOID:8893
Diabetes insipidus contraindication 15771004 DOID:9409
Polyuria contraindication 28442001
Hypothyroidism contraindication 40930008 DOID:1459
Conduction disorder of the heart contraindication 44808001
Chronic heart failure contraindication 48447003
Acute infectious disease contraindication 63171007
Hyponatremia contraindication 89627008
Kidney disease contraindication 90708001 DOID:557
Organic mental disorder contraindication 111479008
Plaque psoriasis contraindication 200965009
Pregnancy, function contraindication 289908002
Breastfeeding (mother) contraindication 413712001
Severe dehydration contraindication 450316000
Lithium Toxicity contraindication




🐶 Veterinary Drug Use

None

🐶 Veterinary products

None

Acid dissociation constants calculated using MoKa v3.0.0

None

Orange Book patent data (new drug applications)

None

Orange Book exclusivity data (new drug applications)

None

Bioactivity Summary:

TargetClassPharosUniProtActionTypeActivity value
(-log[M])
Mechanism
action
Bioact sourceMoA source
Glycogen synthase kinase-3 Kinase INHIBITOR CHEMBL CHEMBL
Inositol-1(or 4)-monophosphatase 1 Enzyme INHIBITOR CHEMBL CHEMBL

External reference:

IDSource
D04749 KEGG_DRUG
4018009 VUID
N0000179333 NUI
4018008 VANDF
4018009 VANDF
4019803 VANDF
CHEBI:64735 CHEBI
CHEBI:30145 CHEBI
CHEMBL1201170 ChEMBL_ID
CHEMBL2103738 ChEMBL_ID
CHEMBL1200826 ChEMBL_ID
C070669 MESH_SUPPLEMENTAL_RECORD_UI
7439-93-2 SECONDARY_CAS_RN
DB14507 DRUGBANK_ID
5Z6E9K79YV UNII
13520 PUBCHEM_CID
3028194 PUBCHEM_CID
DB14509 DRUGBANK_ID
203056 RXNORM
1994 MMSL
2001 MMSL
4987 MMSL
d00061 MMSL
001532 NDDF
001534 NDDF
17805003 SNOMEDCT_US
321719003 SNOMEDCT_US
387098001 SNOMEDCT_US
85899009 SNOMEDCT_US
D016651 MESH_DESCRIPTOR_UI
C0125997 UMLSCUI
C0023870 UMLSCUI
CHEMBL2146126 ChEMBL_ID
D008094 MESH_DESCRIPTOR_UI
9FN79X2M3F UNII
6080-58-6 SECONDARY_CAS_RN

Pharmaceutical products:

ProductCategoryIngredientsNDCFormQuantityRouteMarketingLabel
Lithium HUMAN PRESCRIPTION DRUG LABEL 1 0054-3527 SOLUTION 8 meq ORAL NDA 26 sections
Lithium HUMAN PRESCRIPTION DRUG LABEL 1 68094-757 SOLUTION 8 meq ORAL NDA 27 sections