lithium citrate 🐶 Veterinary Use | Indications/Contra | FAERs-F | FAERs-M | Orange Bk | BioActivity |

Stem definitionDrug idCAS RN
4512 919-16-4

Description:

MoleculeDescription

Synonyms:

  • lithium citrate
  • trilithium citrate
  • lithonate
  • lithium citrate hydrate
  • Molecular weight: 209.92
  • Formula: C6H5Li3O7
  • CLOGP:
  • LIPINSKI: None
  • HAC: None
  • HDO: None
  • TPSA: 140.62
  • ALOGS:
  • ROTB: None

Drug dosage:

DoseUnitRoute
24 mmol O

ADMET properties:

None

Approvals:

DateAgencyCompanyOrphan
Dec. 23, 1980 FDA ROXANE

FDA Adverse Event Reporting System (Female)

MedDRA adverse event termLikelihood ratioLikelihood ratio thresholdPatients taking drug having adverse eventPatients taking drug not having adverse eventPatients not taking drug having adverse eventPatients not taking drug not having adverse event
Toxicity to various agents 1391.65 13.37 1279 46226 245971 63195546
Nephrogenic diabetes insipidus 684.53 13.37 156 47349 803 63440714
Tremor 668.15 13.37 646 46859 131593 63309924
Neuroleptic malignant syndrome 643.85 13.37 266 47239 11790 63429727
Mania 560.97 13.37 243 47262 12124 63429393
Drug interaction 473.43 13.37 710 46795 228421 63213096
Hypomania 461.71 13.37 175 47330 6155 63435362
Psychotic disorder 429.02 13.37 257 47248 25455 63416062
Schizophrenia 382.07 13.37 174 47331 9778 63431739
Antipsychotic drug level increased 371.06 13.37 127 47378 3308 63438209
Completed suicide 361.58 13.37 493 47012 145180 63296337
Extrapyramidal disorder 345.81 13.37 178 47327 13106 63428411
Hyperparathyroidism 314.05 13.37 106 47399 2643 63438874
Tardive dyskinesia 299.34 13.37 140 47365 8362 63433155
Agitation 275.30 13.37 278 47227 59479 63382038
Suicidal ideation 266.94 13.37 279 47226 62142 63379375
Ataxia 264.14 13.37 156 47349 15039 63426478
Catatonia 260.19 13.37 105 47400 4372 63437145
Sedation 256.96 13.37 221 47284 38588 63402929
Bipolar disorder 222.69 13.37 112 47393 7848 63433669
Suicide attempt 221.51 13.37 250 47255 60668 63380849
Jaundice cholestatic 216.56 13.37 107 47398 7217 63434300
Serotonin syndrome 209.76 13.37 173 47332 28509 63413008
Pain 205.96 13.37 153 47352 740475 62701042
Akathisia 194.15 13.37 107 47398 9039 63432478
Diabetes insipidus 178.59 13.37 69 47436 2556 63438961
Antipsychotic drug level above therapeutic 175.60 13.37 54 47451 989 63440528
Pleurothotonus 173.96 13.37 57 47448 1292 63440225
Parkinsonism 167.99 13.37 102 47403 10337 63431180
Hypernatraemia 164.21 13.37 90 47415 7519 63433998
Overdose 161.05 13.37 300 47205 114778 63326739
Salivary hypersecretion 158.10 13.37 88 47417 7578 63433939
Drug level increased 157.66 13.37 133 47372 22603 63418914
Delusion 157.24 13.37 103 47402 11914 63429603
Delirium 156.39 13.37 191 47314 50350 63391167
Arthralgia 155.16 13.37 120 47385 569590 62871927
Aggression 151.82 13.37 132 47373 23366 63418151
Confusional state 150.72 13.37 453 47052 235927 63205590
Disorientation 148.66 13.37 165 47340 39287 63402230
Dysarthria 142.96 13.37 168 47337 42543 63398974
Infusion related reaction 142.05 13.37 11 47494 245510 63196007
Systemic lupus erythematosus 141.71 13.37 3 47502 208915 63232602
Rheumatoid arthritis 139.74 13.37 14 47491 253805 63187712
Somnolence 138.88 13.37 368 47137 178317 63263200
Muscle rigidity 137.05 13.37 93 47412 11407 63430110
Arthropathy 131.76 13.37 12 47493 234780 63206737
Hallucination, auditory 130.18 13.37 94 47411 12730 63428787
Swelling 128.66 13.37 25 47480 275353 63166164
Joint swelling 127.75 13.37 43 47462 327623 63113894
Polyuria 126.09 13.37 79 47426 8463 63433054
Irritability 125.38 13.37 136 47369 31558 63409959
Obsessive-compulsive disorder 122.06 13.37 60 47445 4000 63437517
Hyperreflexia 122.04 13.37 68 47437 5866 63435651
Nasopharyngitis 116.85 13.37 24 47481 254233 63187284
Disturbance in attention 115.99 13.37 143 47362 38046 63403471
Glossodynia 115.98 13.37 4 47501 178872 63262645
Myoclonus 114.51 13.37 95 47410 15773 63425744
Mental status changes 113.44 13.37 144 47361 39455 63402062
Intentional self-injury 111.85 13.37 116 47389 25571 63415946
Dyspnoea 110.07 13.37 205 47300 661108 62780409
Hypersensitivity 109.64 13.37 41 47464 292644 63148873
Alopecia 108.16 13.37 59 47446 337477 63104040
Intentional overdose 107.05 13.37 196 47309 73956 63367561
Abnormal behaviour 106.57 13.37 104 47401 21322 63420195
Paranoia 105.93 13.37 80 47425 11599 63429918
Hypothyroidism 103.57 13.37 143 47362 42489 63399028
Contraindicated product administered 103.25 13.37 19 47486 217629 63223888
Depression 99.29 13.37 348 47157 196144 63245373
Neurotoxicity 98.93 13.37 90 47415 16900 63424617
Mental disorder 91.82 13.37 105 47400 25814 63415703
Sinusitis 91.37 13.37 28 47477 226625 63214892
Polydipsia 90.54 13.37 47 47458 3517 63438000
Cholelithiasis 90.13 13.37 136 47369 43789 63397728
Bipolar I disorder 88.31 13.37 38 47467 1861 63439656
Electrocardiogram QT prolonged 88.00 13.37 159 47346 59371 63382146
Drug intolerance 86.41 13.37 63 47442 308598 63132919
Peripheral swelling 85.86 13.37 46 47459 265896 63175621
Asthma-chronic obstructive pulmonary disease overlap syndrome 85.32 13.37 38 47467 2023 63439494
Hepatotoxicity 85.14 13.37 121 47384 36920 63404597
Granulocytopenia 85.08 13.37 53 47452 5619 63435898
Abdominal discomfort 84.13 13.37 70 47435 320815 63120702
Antipsychotic drug level below therapeutic 83.11 13.37 23 47482 285 63441232
Fatigue 82.97 13.37 363 47142 887665 62553852
Blood bilirubin increased 81.96 13.37 119 47386 37021 63404496
Total lung capacity increased 81.18 13.37 38 47467 2272 63439245
Weight increased 80.53 13.37 397 47108 260395 63181122
Treatment noncompliance 80.06 13.37 118 47387 37207 63404310
Hypercalcaemia 79.54 13.37 102 47403 28220 63413297
Stomatitis 78.02 13.37 7 47498 138718 63302799
Libido increased 76.27 13.37 31 47474 1314 63440203
Rash 74.21 13.37 197 47308 560674 62880843
Euphoric mood 74.15 13.37 46 47459 4841 63436676
Camptocormia 73.92 13.37 21 47484 288 63441229
Dyskinesia 72.75 13.37 104 47401 31898 63409619
Dystonia 72.35 13.37 69 47436 13750 63427767
Sopor 72.18 13.37 86 47419 22078 63419439
Poisoning 70.95 13.37 68 47437 13632 63427885
Mutism 70.53 13.37 31 47474 1599 63439918
Parathyroid tumour benign 70.39 13.37 25 47480 728 63440789
Somatic symptom disorder 70.23 13.37 36 47469 2624 63438893
Nephropathy 70.17 13.37 49 47456 6292 63435225
Body tinea 69.32 13.37 32 47473 1853 63439664
Apathy 68.39 13.37 55 47450 8739 63432778
Cogwheel rigidity 67.97 13.37 32 47473 1938 63439579
Aphasia 67.44 13.37 102 47403 32898 63408619
Pruritus 67.35 13.37 104 47401 361349 63080168
Depressed mood 66.73 13.37 113 47392 40078 63401439
Grandiosity 65.56 13.37 19 47486 281 63441236
Anaemia 65.30 13.37 74 47431 293356 63148161
Inhibitory drug interaction 65.09 13.37 35 47470 2814 63438703
Drug abuse 64.18 13.37 157 47348 72361 63369156
Blood prolactin increased 63.59 13.37 37 47468 3466 63438051
Schizoaffective disorder 63.01 13.37 37 47468 3525 63437992
Infection 62.52 13.37 48 47457 229125 63212392
Restlessness 61.56 13.37 92 47413 29361 63412156
Psychomotor hyperactivity 61.13 13.37 56 47449 10607 63430910
Gastrointestinal disorder 61.05 13.37 12 47493 131227 63310290
Depressed level of consciousness 61.00 13.37 140 47365 61938 63379579
Postural tremor 58.36 13.37 18 47487 333 63441184
Back pain 58.35 13.37 67 47438 264078 63177439
Encephalopathy 58.14 13.37 104 47401 38516 63403001
Chronic kidney disease 58.06 13.37 114 47391 45284 63396233
Logorrhoea 57.80 13.37 31 47474 2479 63439038
Treatment failure 57.80 13.37 39 47466 199004 63242513
Pain in extremity 57.42 13.37 100 47405 331386 63110131
Resting tremor 57.29 13.37 22 47483 801 63440716
Hostility 57.28 13.37 28 47477 1844 63439673
Therapeutic product effect decreased 57.25 13.37 37 47468 193150 63248367
Brugada syndrome 56.58 13.37 18 47487 370 63441147
Anticholinergic syndrome 56.49 13.37 30 47475 2352 63439165
Blister 56.09 13.37 14 47491 129800 63311717
Altered state of consciousness 55.89 13.37 81 47424 25149 63416368
Anger 53.76 13.37 56 47449 12400 63429117
Impaired healing 53.02 13.37 7 47498 102535 63338982
Electrocardiogram T wave abnormal 52.95 13.37 29 47476 2418 63439099
Pressure of speech 52.67 13.37 20 47485 706 63440811
Tachyphrenia 52.64 13.37 24 47481 1350 63440167
Discomfort 52.46 13.37 30 47475 167344 63274173
Anxiety 52.06 13.37 309 47196 217232 63224285
Mood swings 51.67 13.37 66 47439 18182 63423335
Cough 50.97 13.37 88 47417 292655 63148862
Personality disorder 50.92 13.37 39 47466 5772 63435745
Product use issue 50.82 13.37 54 47451 220466 63221051
Infection susceptibility increased 50.55 13.37 32 47473 3489 63438028
Schizoaffective disorder bipolar type 49.60 13.37 13 47492 129 63441388
Nasal polyps 49.59 13.37 39 47466 6000 63435517
Stupor 49.57 13.37 34 47471 4241 63437276
Drug reaction with eosinophilia and systemic symptoms 49.51 13.37 90 47415 33746 63407771
Abdominal pain upper 49.33 13.37 49 47456 206395 63235122
Myocarditis 49.26 13.37 49 47456 10276 63431241
Febrile neutropenia 48.85 13.37 14 47491 118435 63323082
Glucose tolerance impaired 48.75 13.37 40 47465 6537 63434980
Leukocytosis 48.57 13.37 77 47428 25858 63415659
Blood creatine phosphokinase increased 48.46 13.37 84 47421 30346 63411171
Cardio-respiratory arrest 48.02 13.37 125 47380 59834 63381683
Disease progression 47.95 13.37 16 47489 122742 63318775
Mental impairment 47.88 13.37 56 47449 14095 63427422
Psychiatric symptom 47.86 13.37 36 47469 5187 63436330
Hallucination 47.77 13.37 118 47387 54699 63386818
Hyperprolactinaemia 47.56 13.37 32 47473 3868 63437649
Product tampering 47.27 13.37 16 47489 402 63441115
Withdrawal syndrome 46.94 13.37 66 47439 19931 63421586
Death 46.80 13.37 135 47370 374246 63067271
Neurological symptom 46.74 13.37 37 47468 5746 63435771
Action tremor 46.54 13.37 15 47490 322 63441195
Adulterated product 46.17 13.37 14 47491 244 63441273
White blood cell count increased 46.04 13.37 108 47397 48453 63393064
Intentional product use issue 46.04 13.37 19 47486 127873 63313644
Speech disorder 45.99 13.37 97 47408 40532 63400985
Atrial fibrillation 45.91 13.37 15 47490 116621 63324896
Psoriatic arthropathy 45.55 13.37 7 47498 91513 63350004
Soft tissue injury 45.48 13.37 23 47482 1629 63439888
Lethargy 45.09 13.37 117 47388 55890 63385627
Hypothermia 44.72 13.37 53 47452 13528 63427989
Arthritis 43.75 13.37 16 47489 115905 63325612
Galactorrhoea 43.41 13.37 31 47474 4124 63437393
Drooling 43.06 13.37 30 47475 3838 63437679
Claustrophobia 42.88 13.37 19 47486 999 63440518
Sleep-related eating disorder 42.79 13.37 18 47487 833 63440684
Fibromyalgia 42.77 13.37 5 47500 80415 63361102
Poor quality sleep 42.70 13.37 63 47442 19872 63421645
Renal cyst 42.12 13.37 45 47460 10257 63431260
Sarcoidosis 41.99 13.37 38 47467 7084 63434433
Diarrhoea 41.83 13.37 339 47166 715027 62726490
Amenorrhoea 41.76 13.37 44 47461 9870 63431647
Oculogyric crisis 41.73 13.37 22 47483 1699 63439818
Persecutory delusion 41.67 13.37 26 47479 2764 63438753
Substance abuse 41.55 13.37 32 47473 4775 63436742
Asterixis 40.05 13.37 20 47485 1379 63440138
Major depression 40.02 13.37 39 47466 7979 63433538
Urticaria 40.01 13.37 39 47466 165763 63275754
Goitre 39.53 13.37 34 47471 5927 63435590
Neutrophil count increased 39.47 13.37 55 47450 16472 63425045
Drug withdrawal syndrome 39.36 13.37 72 47433 27122 63414395
Thinking abnormal 39.19 13.37 44 47461 10599 63430918
Rhabdomyolysis 38.71 13.37 95 47410 43856 63397661
Hallucination, visual 38.51 13.37 59 47446 19239 63422278
Cerebellar atrophy 38.21 13.37 16 47489 732 63440785
Headache 37.95 13.37 298 47207 632943 62808574
Post-traumatic neck syndrome 37.89 13.37 22 47483 2052 63439465
Respiratory arrest 37.02 13.37 78 47427 32567 63408950
Asthma 37.01 13.37 25 47480 127536 63313981
Parkinsonian gait 36.58 13.37 14 47491 505 63441012
Sternal fracture 36.20 13.37 22 47483 2232 63439285
Clonus 36.06 13.37 29 47476 4607 63436910
Visuospatial deficit 36.05 13.37 7 47498 13 63441504
Enuresis 35.98 13.37 23 47482 2550 63438967
COVID-19 35.82 13.37 20 47485 113083 63328434
Lower respiratory tract infection 35.69 13.37 28 47477 132279 63309238
Cognitive disorder 35.48 13.37 107 47398 55708 63385809
Electroencephalogram abnormal 35.19 13.37 26 47479 3646 63437871
Muscle twitching 34.92 13.37 57 47448 19611 63421906
Impulsive behaviour 34.92 13.37 19 47486 1564 63439953
Blood sodium increased 34.72 13.37 23 47482 2709 63438808
Haemodialysis 34.68 13.37 38 47467 8909 63432608
Gastrointestinal haemorrhage 34.58 13.37 9 47496 81167 63360350
Bronchitis 34.26 13.37 26 47479 124909 63316608
Psychiatric decompensation 34.23 13.37 18 47487 1383 63440134
Electrocardiogram T wave inversion 34.15 13.37 25 47480 3456 63438061
Maternal exposure during pregnancy 34.03 13.37 71 47434 219991 63221526
Injection site erythema 33.98 13.37 10 47495 83164 63358353
Hyperlipidaemia 33.78 13.37 56 47449 19515 63422002
Drug level above therapeutic 33.07 13.37 28 47477 4777 63436740
Choreoathetosis 32.79 13.37 13 47492 516 63441001
Insomnia 32.25 13.37 273 47232 214979 63226538
Renal oncocytoma 32.15 13.37 7 47498 28 63441489
Myocardial oedema 31.60 13.37 10 47495 202 63441315
Hereditary ataxia 31.57 13.37 7 47498 31 63441486
Acute psychosis 31.47 13.37 21 47484 2504 63439013
Osteoarthritis 31.45 13.37 16 47489 95327 63346190
Cardiac murmur 31.19 13.37 46 47459 14506 63427011
Papillary thyroid cancer 31.14 13.37 20 47485 2236 63439281
General physical health deterioration 31.12 13.37 65 47440 201337 63240180
Affect lability 31.05 13.37 40 47465 11111 63430406
Rhinitis allergic 31.00 13.37 41 47464 11686 63429831
Hyperthyroidism 30.89 13.37 46 47459 14627 63426890
Social avoidant behaviour 30.54 13.37 22 47483 2966 63438551
Muscle injury 30.33 13.37 6 47499 65339 63376178
Ileus paralytic 30.26 13.37 26 47479 4525 63436992
Memory impairment 30.19 13.37 156 47349 104102 63337415
Acute kidney injury 29.94 13.37 315 47190 263100 63178417
Knee arthroplasty 29.76 13.37 3 47502 54203 63387314
Neuropathy peripheral 29.48 13.37 25 47480 113642 63327875
Bruxism 29.45 13.37 23 47482 3502 63438015
Bradykinesia 29.26 13.37 27 47478 5161 63436356
Behaviour disorder 29.20 13.37 22 47483 3177 63438340
Eye movement disorder 29.08 13.37 27 47478 5201 63436316
Mobility decreased 28.64 13.37 29 47476 121130 63320387
Depressive symptom 28.43 13.37 24 47481 4078 63437439
Musculoskeletal pain 28.25 13.37 17 47488 92260 63349257
Self-injurious ideation 28.15 13.37 20 47485 2639 63438878
Nodal rhythm 27.96 13.37 17 47488 1726 63439791
Pulse abnormal 27.88 13.37 19 47486 2345 63439172
Bradyphrenia 27.68 13.37 30 47475 6950 63434567
Myoclonic epilepsy 27.52 13.37 15 47490 1239 63440278
Brain injury 27.45 13.37 30 47475 7013 63434504
Suspected suicide 27.40 13.37 29 47476 6539 63434978
Mydriasis 27.38 13.37 39 47466 11917 63429600
Purpura 27.35 13.37 38 47467 11347 63430170
Impaired self-care 26.86 13.37 17 47488 1853 63439664
Drug hypersensitivity 26.44 13.37 131 47374 310556 63130961
Lung disorder 26.34 13.37 7 47498 62254 63379263
Ammonia increased 25.81 13.37 24 47481 4632 63436885
Chest pain 25.42 13.37 80 47425 215879 63225638
Abdominal pain 25.39 13.37 123 47382 293333 63148184
Hypotonia 25.37 13.37 33 47472 9252 63432265
Ill-defined disorder 25.11 13.37 15 47490 81740 63359777
Hallucinations, mixed 25.06 13.37 24 47481 4805 63436712
Neuropsychiatric symptoms 24.97 13.37 12 47493 761 63440756
Feeling guilty 24.96 13.37 11 47494 571 63440946
Sepsis 24.86 13.37 48 47457 153075 63288442
Differential white blood cell count abnormal 24.78 13.37 12 47493 774 63440743
Thrombosis 24.32 13.37 9 47496 64746 63376771
Delusion of reference 24.31 13.37 7 47498 101 63441416
International normalised ratio abnormal 24.29 13.37 20 47485 3284 63438233
Ideas of reference 24.19 13.37 7 47498 103 63441414
Judgement impaired 24.13 13.37 12 47493 820 63440697
Irritable bowel syndrome 24.10 13.37 16 47489 82396 63359121
Cerebral atrophy 24.09 13.37 24 47481 5042 63436475
Antidepressant drug level increased 23.99 13.37 9 47496 307 63441210
Hypertonia 23.98 13.37 23 47482 4614 63436903
Polyhydramnios 23.85 13.37 17 47488 2254 63439263
Thyrotoxic crisis 23.55 13.37 12 47493 864 63440653
Adams-Stokes syndrome 23.52 13.37 6 47499 53 63441464
Injection site pruritus 23.51 13.37 3 47502 45113 63396404
Anaphylactic reaction 23.49 13.37 10 47495 66090 63375427
Hyperammonaemia 23.44 13.37 24 47481 5208 63436309
Histrionic personality disorder 23.42 13.37 6 47499 54 63441463
Nystagmus 23.39 13.37 26 47479 6194 63435323
Cardiac arrest 23.10 13.37 133 47372 92412 63349105
Cerebellar syndrome 23.09 13.37 20 47485 3519 63437998
Muscle contractions involuntary 23.06 13.37 17 47488 2375 63439142
Flat affect 22.89 13.37 14 47491 1436 63440081
Urinary incontinence 22.87 13.37 64 47441 31950 63409567
Injection site swelling 22.86 13.37 4 47501 47568 63393949
Electroconvulsive therapy 22.76 13.37 6 47499 61 63441456
Hyperthermia 22.66 13.37 31 47474 9125 63432392
Injection site pain 22.57 13.37 39 47466 129761 63311756
Refusal of treatment by patient 22.45 13.37 24 47481 5473 63436044
Oxygen saturation decreased 22.34 13.37 20 47485 88565 63352952
Cerebrovascular accident 22.13 13.37 29 47476 107995 63333522
CSWS syndrome 22.05 13.37 5 47500 25 63441492
Cardiac failure congestive 21.99 13.37 22 47483 92411 63349106
Affective disorder 21.93 13.37 25 47480 6121 63435396
Impaired quality of life 21.88 13.37 38 47467 13745 63427772
Blunted affect 21.84 13.37 8 47497 255 63441262
Nephropathy toxic 21.82 13.37 31 47474 9448 63432069
Gestational diabetes 21.65 13.37 29 47476 8367 63433150
Cardiac hypertrophy 21.55 13.37 12 47493 1033 63440484
Bone pain 21.54 13.37 7 47498 54634 63386883
Influenza 21.45 13.37 30 47475 108692 63332825
Drug level decreased 21.41 13.37 28 47477 7891 63433626
Staring 21.39 13.37 14 47491 1616 63439901
Platelet count decreased 21.02 13.37 34 47471 116088 63325429
Seizure 20.80 13.37 170 47335 132464 63309053
Lactate pyruvate ratio increased 20.62 13.37 6 47499 90 63441427
Coordination abnormal 20.61 13.37 37 47468 13736 63427781
Thyroiditis 20.41 13.37 16 47489 2450 63439067
Mucosal inflammation 20.38 13.37 5 47500 46923 63394594
Productive cough 20.27 13.37 11 47494 63197 63378320
Rebound psychosis 20.14 13.37 7 47498 191 63441326
Dyspnoea exertional 20.07 13.37 10 47495 60292 63381225
International normalised ratio increased 20.05 13.37 5 47500 46420 63395097
Limbic encephalitis 20.05 13.37 8 47497 323 63441194
Electrocardiogram abnormal 19.65 13.37 29 47476 9150 63432367
Dialysis 19.58 13.37 31 47474 10396 63431121
Hyporeflexia 19.48 13.37 14 47491 1881 63439636
Metabolic syndrome 19.29 13.37 13 47492 1575 63439942
Human herpesvirus 6 infection reactivation 19.10 13.37 8 47497 366 63441151
Dysphoria 19.09 13.37 21 47484 4945 63436572
Slow response to stimuli 18.99 13.37 11 47494 1021 63440496
Bundle branch block right 18.98 13.37 21 47484 4977 63436540
Toxic encephalopathy 18.95 13.37 24 47481 6555 63434962
Arachnoid cyst 18.94 13.37 7 47498 229 63441288
Unresponsive to stimuli 18.88 13.37 62 47443 33754 63407763
Ear infection 18.84 13.37 3 47502 38210 63403307
Mood altered 18.82 13.37 37 47468 14706 63426811
Rhinorrhoea 18.81 13.37 13 47492 65564 63375953
Lipids decreased 18.79 13.37 4 47501 14 63441503
Borderline personality disorder 18.63 13.37 10 47495 801 63440716
Urine osmolarity increased 18.56 13.37 6 47499 130 63441387
Decreased appetite 18.51 13.37 111 47394 250941 63190576
Cystitis 18.48 13.37 9 47496 54982 63386535
Essential tremor 18.46 13.37 11 47494 1077 63440440
Compulsive sexual behaviour 18.29 13.37 5 47500 59 63441458
Blood citric acid increased 18.29 13.37 5 47500 59 63441458
Oscillopsia 18.27 13.37 6 47499 137 63441380
Negativism 18.27 13.37 8 47497 409 63441108
Acquired cystic kidney disease 18.14 13.37 5 47500 61 63441456
Homicidal ideation 18.14 13.37 13 47492 1739 63439778
Pleural effusion 18.11 13.37 26 47479 93184 63348333
Concussion 18.07 13.37 28 47477 9216 63432301
Sluggishness 18.07 13.37 21 47484 5248 63436269
Consciousness fluctuating 18.00 13.37 10 47495 857 63440660
Inflammation 17.99 13.37 21 47484 82252 63359265
Sinus bradycardia 17.95 13.37 36 47469 14515 63427002
Antidepressant drug level above therapeutic 17.91 13.37 8 47497 429 63441088
Skin ulcer 17.90 13.37 5 47500 43040 63398477
Merycism 17.75 13.37 7 47498 274 63441243
Clear cell renal cell carcinoma 17.67 13.37 12 47493 1473 63440044
Bronchiectasis 17.64 13.37 38 47467 16104 63425413
Suicidal behaviour 17.39 13.37 15 47490 2624 63438893
Epileptic encephalopathy 17.37 13.37 7 47498 290 63441227
Body mass index increased 17.29 13.37 11 47494 1209 63440308
Flight of ideas 17.28 13.37 8 47497 466 63441051
Compartment syndrome 17.16 13.37 14 47491 2270 63439247
Blood pressure systolic increased 17.12 13.37 7 47498 47390 63394127
Musculoskeletal stiffness 16.77 13.37 76 47429 184542 63256975
Tooth injury 16.72 13.37 11 47494 1281 63440236
Tonsillar hypertrophy 16.67 13.37 10 47495 991 63440526
Paroxysmal perceptual alteration 16.52 13.37 3 47502 3 63441514
Acalculia 16.52 13.37 3 47502 3 63441514
Ascites 16.44 13.37 5 47500 40723 63400794
Colitis 16.22 13.37 8 47497 48520 63392997
Choluria 16.13 13.37 6 47499 200 63441317
Paraesthesia 15.87 13.37 62 47443 156904 63284613
Gaze palsy 15.77 13.37 11 47494 1409 63440108
Septic shock 15.68 13.37 16 47489 66613 63374904
Status epilepticus 15.67 13.37 35 47470 15198 63426319
Impaired work ability 15.62 13.37 38 47467 17437 63424080
Hypokalaemia 15.60 13.37 34 47471 103770 63337747
Urinary retention 15.55 13.37 54 47451 30247 63411270
Echolalia 15.48 13.37 6 47499 224 63441293
Neonatal respiratory distress 15.45 13.37 7 47498 388 63441129
Hyperparathyroidism primary 15.37 13.37 7 47498 393 63441124
Malaise 15.35 13.37 219 47286 415735 63025782
Pneumonia 15.31 13.37 245 47260 456522 62984995
Weight decreased 15.26 13.37 133 47372 276665 63164852
Middle insomnia 15.26 13.37 31 47474 12612 63428905
Dysphemia 15.24 13.37 14 47491 2661 63438856
Thrombocytopenia 15.10 13.37 60 47445 151097 63290420
Sleep apnoea syndrome 15.02 13.37 52 47453 29081 63412436
Haemoglobin decreased 15.01 13.37 57 47448 145428 63296089
Joint range of motion decreased 15.00 13.37 3 47502 32425 63409092
Cerebellar ataxia 14.99 13.37 9 47496 893 63440624
Delusional perception 14.97 13.37 6 47499 245 63441272
Glomerulonephritis minimal lesion 14.88 13.37 6 47499 249 63441268
Upper respiratory tract infection 14.87 13.37 24 47481 82023 63359494
Posture abnormal 14.85 13.37 13 47492 2319 63439198
Pain in jaw 14.80 13.37 7 47498 43489 63398028
Balance disorder 14.77 13.37 111 47394 84311 63357206
Stereotypy 14.70 13.37 7 47498 435 63441082
Hyperhidrosis 14.69 13.37 134 47371 107702 63333815
Nuchal rigidity 14.67 13.37 8 47497 661 63440856
Distractibility 14.67 13.37 7 47498 437 63441080
Increased appetite 14.57 13.37 26 47479 9604 63431913
Throat irritation 14.53 13.37 5 47500 37642 63403875
Loss of personal independence in daily activities 14.51 13.37 32 47473 97258 63344259
Thought insertion 14.44 13.37 3 47502 9 63441508
Psychotic disorder due to a general medical condition 14.42 13.37 6 47499 270 63441247
Cardiac failure 14.41 13.37 28 47477 89114 63352403
Bone density decreased 14.39 13.37 33 47472 14579 63426938
Unmasking of previously unidentified disease 14.34 13.37 9 47496 967 63440550
Movement disorder 14.21 13.37 42 47463 21619 63419898
Neutrophilia 14.18 13.37 17 47488 4389 63437128
Restless legs syndrome 14.18 13.37 38 47467 18493 63423024
Dry skin 14.16 13.37 13 47492 56874 63384643
Atrioventricular block second degree 14.10 13.37 16 47489 3898 63437619
Amimia 14.07 13.37 4 47501 55 63441462
Haemorrhage 13.97 13.37 15 47490 61007 63380510
Abulia 13.97 13.37 7 47498 486 63441031
Agranulocytosis 13.96 13.37 46 47459 25088 63416429
Radial nerve palsy 13.83 13.37 7 47498 497 63441020
Incoherent 13.80 13.37 17 47488 4513 63437004
Skin disorder 13.79 13.37 51 47454 29456 63412061
Femur fracture 13.78 13.37 7 47498 41749 63399768
Thought blocking 13.66 13.37 5 47500 159 63441358
Urine output increased 13.66 13.37 10 47495 1383 63440134
Melaena 13.65 13.37 3 47502 30362 63411155
Respiratory tract infection 13.62 13.37 7 47498 41476 63400041
Haematochezia 13.61 13.37 12 47493 53532 63387985
Decreased activity 13.57 13.37 20 47485 6300 63435217

FDA Adverse Event Reporting System (Male)

MedDRA adverse event termLikelihood ratioLikelihood ratio thresholdPatients taking drug having adverse eventPatients taking drug not having adverse eventPatients not taking drug having adverse eventPatients not taking drug not having adverse event
Toxicity to various agents 907.15 14.34 1088 36183 199274 34720386
Neuroleptic malignant syndrome 610.44 14.34 323 36948 17611 34902049
Mania 505.01 14.34 232 37039 9279 34910381
Nephrogenic diabetes insipidus 464.42 14.34 131 37140 1190 34918470
Tremor 437.85 14.34 488 36783 82099 34837561
Antipsychotic drug level increased 365.02 14.34 142 37129 3723 34915937
Akathisia 327.59 14.34 164 37107 7945 34911715
Suicide attempt 276.71 14.34 270 37001 38846 34880814
Obsessive-compulsive disorder 271.30 14.34 128 37143 5436 34914224
Extrapyramidal disorder 261.75 14.34 166 37105 12714 34906946
Antipsychotic drug level below therapeutic 256.26 14.34 98 37173 2449 34917211
Psychotic disorder 254.65 14.34 210 37061 24242 34895418
Drug interaction 235.34 14.34 647 36624 225299 34694361
Parkinsonism 219.99 14.34 126 37145 8012 34911648
Schizophrenia 197.08 14.34 120 37151 8546 34911114
Serotonin syndrome 192.64 14.34 164 37107 19769 34899891
Antipsychotic drug level above therapeutic 189.92 14.34 65 37206 1168 34918492
Suicidal ideation 179.04 14.34 218 37053 40170 34879490
Hallucination, auditory 175.95 14.34 126 37145 11791 34907869
Sedation 173.33 14.34 158 37113 20848 34898812
Euphoric mood 173.29 14.34 95 37176 5546 34914114
Disinhibition 168.98 14.34 78 37193 3148 34916512
Therapeutic product effect variable 159.41 14.34 69 37202 2387 34917273
Increased appetite 159.07 14.34 99 37172 7330 34912330
Agitation 152.34 14.34 242 37029 57157 34862503
Aggression 151.49 14.34 197 37074 38767 34880893
Granulocytopenia 149.48 14.34 91 37180 6476 34913184
Weight increased 146.49 14.34 313 36958 92720 34826940
Completed suicide 146.29 14.34 323 36948 97845 34821815
Hypomania 145.71 14.34 64 37207 2295 34917365
Irritability 135.81 14.34 149 37122 24541 34895119
Diabetes insipidus 135.51 14.34 65 37206 2863 34916797
Psychomotor hyperactivity 126.80 14.34 95 37176 9527 34910133
Leukopenia 113.65 14.34 224 37047 62632 34857028
Salivary hypersecretion 113.14 14.34 85 37186 8559 34911101
Dysarthria 112.67 14.34 161 37110 34621 34885039
Febrile neutropenia 109.35 14.34 10 37261 136839 34782821
Dyspnoea 107.82 14.34 147 37124 376635 34543025
Bipolar disorder 105.05 14.34 59 37212 3610 34916050
Delusion of grandeur 103.80 14.34 41 37230 1119 34918541
Tardive dyskinesia 101.38 14.34 68 37203 5722 34913938
Overdose 100.58 14.34 267 37004 90792 34828868
Neutrophil count increased 100.45 14.34 107 37164 17039 34902621
Dyskinesia 97.67 14.34 120 37151 22293 34897367
Muscle rigidity 96.43 14.34 84 37187 10434 34909226
Delusion 94.48 14.34 90 37181 12545 34907115
Abnormal behaviour 93.53 14.34 124 37147 24845 34894815
Ataxia 92.97 14.34 93 37178 13760 34905900
Death 92.56 14.34 178 37093 397871 34521789
Arthralgia 89.02 14.34 35 37236 170006 34749654
Schizoaffective disorder 88.47 14.34 38 37233 1289 34918371
Hypernatraemia 86.41 14.34 72 37199 8418 34911242
Priapism 83.49 14.34 57 37214 4937 34914723
Bruxism 81.76 14.34 39 37232 1696 34917964
Confusional state 81.72 14.34 337 36934 143823 34775837
Catatonia 80.81 14.34 56 37215 4969 34914691
Myoclonus 79.46 14.34 88 37183 14637 34905023
Anaemia 77.27 14.34 81 37190 233254 34686406
Oppositional defiant disorder 77.04 14.34 27 37244 522 34919138
Mental status changes 76.52 14.34 142 37129 37941 34881719
Coordination abnormal 76.09 14.34 64 37207 7580 34912080
White blood cell count increased 75.97 14.34 148 37123 41003 34878657
Affective disorder 75.84 14.34 51 37220 4309 34915351
Hyperparathyroidism 74.92 14.34 33 37238 1191 34918469
Cough 73.62 14.34 34 37237 150106 34769554
Decreased eye contact 71.99 14.34 25 37246 470 34919190
Delirium 70.27 14.34 149 37122 43842 34875818
Homicidal ideation 68.41 14.34 40 37231 2642 34917018
Myocarditis 67.41 14.34 78 37193 13604 34906056
Pain 66.68 14.34 72 37199 204603 34715057
Malignant neoplasm progression 66.27 14.34 8 37263 88038 34831622
Obesity 66.12 14.34 75 37196 12803 34906857
Dystonia 65.86 14.34 69 37202 10776 34908884
Dyslipidaemia 63.06 14.34 57 37214 7431 34912229
Pain in extremity 63.02 14.34 28 37243 126485 34793175
Electrocardiogram QRS complex prolonged 61.55 14.34 47 37224 4847 34914813
Cognitive disorder 61.45 14.34 110 37161 28583 34891077
Treatment noncompliance 60.53 14.34 108 37163 27992 34891668
Pneumonia 60.05 14.34 193 37078 362434 34557226
Intentional overdose 59.69 14.34 139 37132 43535 34876125
Hyperreflexia 59.38 14.34 39 37232 3167 34916493
Neurotoxicity 59.23 14.34 84 37187 17926 34901734
Pancytopenia 57.88 14.34 15 37256 95142 34824518
Affect lability 56.79 14.34 40 37231 3643 34916017
Restlessness 54.96 14.34 98 37173 25384 34894276
Brugada syndrome 53.61 14.34 23 37248 778 34918882
Depression 53.39 14.34 225 37046 96873 34822787
Pruritus 53.17 14.34 44 37227 141937 34777723
Dystonic tremor 51.87 14.34 16 37255 203 34919457
Interstitial lung disease 51.49 14.34 5 37266 65277 34854383
Prescribed overdose 51.28 14.34 60 37211 10587 34909073
Back pain 50.41 14.34 34 37237 121755 34797905
Clonus 49.83 14.34 33 37238 2717 34916943
Anxiety 49.78 14.34 224 37047 99204 34820456
Atrial fibrillation 49.56 14.34 35 37236 122358 34797302
Hyperprolactinaemia 49.35 14.34 27 37244 1569 34918091
Thinking abnormal 48.33 14.34 45 37226 6092 34913568
Somnolence 48.10 14.34 240 37031 110876 34808784
Polydipsia 47.92 14.34 37 37234 3878 34915782
Disorientation 46.85 14.34 107 37164 33081 34886579
Peripheral swelling 46.67 14.34 12 37259 76529 34843131
Depressed level of consciousness 46.60 14.34 125 37146 42716 34876944
General physical health deterioration 46.49 14.34 41 37230 128228 34791432
Lethargy 45.76 14.34 121 37150 41001 34878659
Speech disorder 45.72 14.34 91 37180 25595 34894065
Rhinalgia 44.59 14.34 22 37249 1031 34918629
Failure to suspend medication 44.58 14.34 17 37254 421 34919239
Rash 43.05 14.34 110 37161 222642 34697018
Mental disorder 42.89 14.34 66 37205 15143 34904517
Sepsis 42.58 14.34 70 37201 166491 34753169
Septic shock 42.40 14.34 12 37259 71822 34847838
Disease progression 42.33 14.34 32 37239 108045 34811615
Thrombocytopenia 41.51 14.34 64 37207 156183 34763477
Choreoathetosis 41.43 14.34 21 37250 1043 34918617
Oedema peripheral 41.40 14.34 40 37231 119772 34799888
Blood creatine phosphokinase increased 41.09 14.34 123 37148 44734 34874926
Cardiac failure congestive 40.56 14.34 19 37252 83251 34836409
Insomnia 40.50 14.34 218 37053 103689 34815971
Electrocardiogram QT prolonged 40.10 14.34 115 37156 40837 34878823
Enuresis 39.67 14.34 27 37244 2326 34917334
Infusion related reaction 39.48 14.34 5 37266 53052 34866608
Abulia 39.40 14.34 17 37254 583 34919077
Leukocytosis 38.97 14.34 82 37189 23983 34895677
Mental impairment 38.23 14.34 51 37220 10271 34909389
Paranoia 37.79 14.34 55 37216 12013 34907647
Drug level above therapeutic 36.99 14.34 33 37238 4228 34915432
Blood thyroid stimulating hormone decreased 36.89 14.34 24 37247 1917 34917743
Apathy 36.65 14.34 41 37230 6891 34912769
Antipsychotic drug level decreased 36.50 14.34 19 37252 998 34918662
Hypothyroidism 35.94 14.34 73 37198 20829 34898831
Fatigue 35.82 14.34 240 37031 370413 34549247
Pressure of speech 35.74 14.34 15 37256 480 34919180
Nephropathy 34.77 14.34 37 37234 5880 34913780
Grandiosity 34.36 14.34 13 37258 315 34919345
Hyperparathyroidism primary 34.22 14.34 11 37260 161 34919499
Plasma cell myeloma 33.73 14.34 3 37268 42034 34877626
Trismus 33.68 14.34 25 37246 2470 34917190
Joint swelling 33.55 14.34 11 37260 59879 34859781
Distractibility 32.70 14.34 13 37258 361 34919299
Depressed mood 32.66 14.34 67 37204 19250 34900410
Bipolar I disorder 32.01 14.34 16 37255 771 34918889
Myocardial infarction 31.76 14.34 50 37221 121035 34798625
Hyperkinesia 31.51 14.34 21 37250 1747 34917913
Decreased appetite 31.48 14.34 83 37188 166309 34753351
Leukaemia 31.06 14.34 31 37240 4572 34915088
Ascites 31 14.34 6 37265 46565 34873095
Cardiac failure 30.89 14.34 31 37240 91217 34828443
Thrombosis 30.58 14.34 8 37263 50450 34869210
Headache 30.24 14.34 111 37160 200524 34719136
Logorrhoea 29.85 14.34 23 37248 2403 34917257
Drug level increased 29.82 14.34 70 37201 22026 34897634
Muscle spasms 29.62 14.34 22 37249 74979 34844681
Infection 29.53 14.34 32 37239 90883 34828777
Flight of ideas 29.16 14.34 12 37259 365 34919295
Epistaxis 28.81 14.34 13 37258 58238 34861422
Lymphocyte count abnormal 28.28 14.34 17 37254 1181 34918479
Eosinophil count decreased 27.99 14.34 18 37253 1410 34918250
Sexual dysfunction 27.85 14.34 34 37237 6269 34913391
Abdominal pain 27.73 14.34 86 37185 163532 34756128
Therapeutic product effect incomplete 27.65 14.34 117 37154 50424 34869236
Disturbance in attention 27.50 14.34 75 37196 25870 34893790
Anger 27.30 14.34 47 37224 11837 34907823
Intentional product use issue 27.10 14.34 15 37256 59801 34859859
Patient restraint 27.06 14.34 8 37263 87 34919573
Blood prolactin increased 26.87 14.34 19 37252 1741 34917919
Diabetes mellitus 26.81 14.34 110 37161 46763 34872897
Polyuria 26.73 14.34 39 37232 8535 34911125
Prostate cancer 26.62 14.34 5 37266 39644 34880016
Blood sodium increased 26.61 14.34 23 37248 2825 34916835
Tachycardia 26.61 14.34 168 37103 84604 34835056
Blunted affect 26.30 14.34 11 37260 349 34919311
Psychiatric decompensation 26.00 14.34 23 37248 2914 34916746
Defect conduction intraventricular 25.95 14.34 11 37260 361 34919299
Erythema 25.89 14.34 34 37237 88746 34830914
Gastrointestinal haemorrhage 25.69 14.34 34 37237 88443 34831217
Diarrhoea 25.31 14.34 280 36991 389632 34530028
Coronary artery disease 25.14 14.34 10 37261 48295 34871365
Acute myocardial infarction 25.02 14.34 13 37258 53706 34865954
Crying 24.90 14.34 31 37240 5831 34913829
Abdominal distension 24.63 14.34 16 37255 58476 34861184
Angioedema 24.49 14.34 5 37266 37369 34882291
Haemoptysis 24.41 14.34 4 37267 35002 34884658
Cerebral haemorrhage 24.34 14.34 4 37267 34933 34884727
Diabetic coma 24.24 14.34 14 37257 903 34918757
Feelings of worthlessness 24.15 14.34 10 37261 309 34919351
Mood altered 24.06 14.34 38 37233 8914 34910746
Cogwheel rigidity 23.96 14.34 16 37255 1336 34918324
Blood triglycerides increased 23.80 14.34 49 37222 14110 34905550
Cerebellar syndrome 23.77 14.34 20 37251 2368 34917292
Urticaria 23.73 14.34 19 37252 62358 34857302
Seizure 23.72 14.34 192 37079 104665 34814995
Weight decreased 23.72 14.34 102 37169 176199 34743461
Oxygen saturation decreased 23.66 14.34 14 37257 53804 34865856
Sleep disorder 23.64 14.34 81 37190 31607 34888053
Pneumonitis 23.33 14.34 4 37267 33874 34885786
Drooling 23.23 14.34 23 37248 3359 34916301
Arthritis 23.20 14.34 3 37268 31343 34888317
Self-injurious ideation 23.01 14.34 17 37254 1667 34917993
Pleural effusion 23 14.34 32 37239 81514 34838146
Long QT syndrome 22.94 14.34 21 37250 2782 34916878
Productive cough 22.90 14.34 6 37265 37807 34881853
Oromandibular dystonia 22.81 14.34 11 37260 490 34919170
Psychotic symptom 22.49 14.34 17 37254 1726 34917934
Metabolic encephalopathy 22.03 14.34 25 37246 4267 34915393
Haemorrhage 21.70 14.34 14 37257 51356 34868304
Conduction disorder 21.69 14.34 18 37253 2092 34917568
Musculoskeletal pain 21.52 14.34 4 37267 31959 34887701
Chest discomfort 21.52 14.34 16 37255 54514 34865146
Hypersensitivity 21.51 14.34 20 37251 61015 34858645
Renal cyst 20.93 14.34 36 37235 9057 34910603
Otospondylomegaepiphyseal dysplasia 20.92 14.34 7 37264 117 34919543
Melaena 20.71 14.34 6 37265 35374 34884286
Metabolic syndrome 20.67 14.34 16 37255 1683 34917977
Autonomic nervous system imbalance 20.66 14.34 19 37252 2532 34917128
Agranulocytosis 20.57 14.34 64 37207 23757 34895903
Stupor 20.49 14.34 20 37251 2871 34916789
High-grade B-cell lymphoma 20.34 14.34 7 37264 128 34919532
Persistent depressive disorder 20.25 14.34 9 37262 332 34919328
Stomatitis 20.23 14.34 10 37261 42504 34877156
Hyperammonaemic encephalopathy 20.18 14.34 18 37253 2306 34917354
Wrong patient received product 20.01 14.34 19 37252 2635 34917025
Cerebral amyloid angiopathy 19.99 14.34 7 37264 135 34919525
Hepatic failure 19.94 14.34 6 37265 34525 34885135
Anaphylactic reaction 19.80 14.34 5 37266 32296 34887364
Hyperkalaemia 19.80 14.34 27 37244 69362 34850298
Multiple organ dysfunction syndrome 19.70 14.34 32 37239 76534 34843126
Cerebrovascular accident 19.52 14.34 38 37233 84773 34834887
Poor quality sleep 19.42 14.34 33 37238 8223 34911437
Dyspnoea exertional 19.39 14.34 11 37260 43268 34876392
Dysphemia 19.36 14.34 15 37256 1580 34918080
Antipsychotic drug level 19.34 14.34 4 37267 7 34919653
Oncocytoma 19.34 14.34 4 37267 7 34919653
Mutism 19.34 14.34 12 37259 883 34918777
Accidental death 19.32 14.34 18 37253 2438 34917222
Convulsive threshold lowered 19.16 14.34 10 37261 528 34919132
Restless legs syndrome 19.13 14.34 33 37238 8321 34911339
Speech sound disorder 19.13 14.34 7 37264 154 34919506
Memory impairment 19.02 14.34 94 37177 43224 34876436
Intentional self-injury 18.99 14.34 44 37227 13727 34905933
Arthropathy 18.92 14.34 3 37268 26904 34892756
Staphylococcal infection 18.37 14.34 6 37265 32754 34886906
Gait disturbance 18.23 14.34 154 37117 84986 34834674
Kidney enlargement 18.08 14.34 11 37260 781 34918879
Nephrolithiasis 18.02 14.34 5 37266 30328 34889332
Secondary tic 17.85 14.34 4 37267 12 34919648
Upper gastrointestinal haemorrhage 17.60 14.34 3 37268 25515 34894145
Pyrexia 17.50 14.34 250 37021 332763 34586897
Altered state of consciousness 17.50 14.34 59 37212 22834 34896826
Hallucination, olfactory 17.45 14.34 7 37264 199 34919461
Withdrawal syndrome 17.40 14.34 40 37231 12415 34907245
Libido increased 17.36 14.34 11 37260 840 34918820
Blood thyroid stimulating hormone increased 17.28 14.34 22 37249 4233 34915427
Drug ineffective 17.19 14.34 621 36650 456130 34463530
Angina pectoris 17.14 14.34 6 37265 31357 34888303
Bone marrow failure 17.05 14.34 5 37266 29248 34890412
Schizoaffective disorder bipolar type 16.93 14.34 6 37265 120 34919540
Drug hypersensitivity 16.92 14.34 38 37233 80491 34839169
Social anxiety disorder 16.90 14.34 8 37263 342 34919318
Herpes zoster 16.51 14.34 8 37263 34391 34885269
Dysphoria 16.45 14.34 16 37255 2286 34917374
Thought blocking 16.35 14.34 6 37265 133 34919527
Bipolar II disorder 16.07 14.34 4 37267 21 34919639
Drug withdrawal syndrome 15.95 14.34 52 37219 19782 34899878
Gastrectomy 15.83 14.34 6 37265 146 34919514
Toxic cardiomyopathy 15.70 14.34 7 37264 260 34919400
Bronchitis 15.69 14.34 13 37258 41950 34877710
Urinary incontinence 15.64 14.34 50 37221 18824 34900836
Haematoma 15.63 14.34 4 37267 25601 34894059
Electrocardiogram abnormal 15.54 14.34 32 37239 9215 34910445
Acarodermatitis 15.49 14.34 8 37263 413 34919247
Cerebral infarction 15.44 14.34 5 37266 27450 34892210
Muscle twitching 15.42 14.34 34 37237 10264 34909396
Impulsive behaviour 15.40 14.34 15 37256 2147 34917513
Metastases to eye 15.32 14.34 5 37266 77 34919583
Blood pressure fluctuation 15.30 14.34 4 37267 25245 34894415
Sinusitis 15.26 14.34 13 37258 41389 34878271
Hypoxia 15.15 14.34 22 37249 55073 34864587
Encephalopathy 15.05 14.34 76 37195 35243 34884417
International normalised ratio increased 14.98 14.34 17 37254 47310 34872350
Abdominal pain upper 14.80 14.34 34 37237 71456 34848204
Electroconvulsive therapy 14.74 14.34 4 37267 31 34919629
Paradoxical drug reaction 14.68 14.34 18 37253 3333 34916327
Neutrophilia 14.65 14.34 20 37251 4117 34915543
Coma 14.61 14.34 91 37180 45587 34874073
Blood creatinine increased 14.50 14.34 160 37111 94816 34824844

FDA Adverse Event Reporting System (Geriatric)

MedDRA adverse event termLikelihood ratioLikelihood ratio thresholdPatients taking drug having adverse eventPatients taking drug not having adverse eventPatients not taking drug having adverse eventPatients not taking drug not having adverse event
Toxicity to various agents 2032.27 13.02 2167 68772 419373 79254076
Neuroleptic malignant syndrome 1128.39 13.02 531 70408 27028 79646421
Nephrogenic diabetes insipidus 1056.05 13.02 267 70672 1867 79671582
Tremor 1007.08 13.02 980 69959 169103 79504346
Mania 828.81 13.02 378 70561 17882 79655567
Drug interaction 666.16 13.02 1264 69675 413919 79259530
Antipsychotic drug level increased 631.57 13.02 227 70712 5730 79667719
Psychotic disorder 579.90 13.02 395 70544 41007 79632442
Hypomania 568.81 13.02 224 70715 7320 79666129
Extrapyramidal disorder 563.21 13.02 312 70627 22367 79651082
Schizophrenia 533.52 13.02 265 70674 15175 79658274
Completed suicide 482.52 13.02 818 70121 244949 79428500
Hyperparathyroidism 395.69 13.02 137 70802 3087 79670362
Serotonin syndrome 391.85 13.02 323 70616 44704 79628745
Agitation 376.93 13.02 454 70485 99261 79574188
Suicidal ideation 362.10 13.02 391 70548 75949 79597500
Ataxia 360.30 13.02 243 70696 24796 79648653
Akathisia 355.67 13.02 192 70747 13067 79660382
Antipsychotic drug level above therapeutic 345.39 13.02 111 70828 1969 79671480
Suicide attempt 340.58 13.02 394 70545 82538 79590911
Sedation 328.92 13.02 311 70628 51584 79621865
Parkinsonism 325.97 13.02 196 70743 16388 79657061
Tardive dyskinesia 311.55 13.02 163 70776 10408 79663041
Catatonia 283.98 13.02 144 70795 8612 79664837
Diabetes insipidus 281.12 13.02 122 70817 5115 79668334
Obsessive-compulsive disorder 269.78 13.02 123 70816 5804 79667645
Hallucination, auditory 258.20 13.02 184 70755 20509 79652940
Aggression 253.92 13.02 268 70671 50690 79622759
Salivary hypersecretion 251.18 13.02 157 70782 14067 79659382
Bipolar disorder 241.95 13.02 124 70815 7583 79665866
Pain 241.23 13.02 166 70773 703636 78969813
Granulocytopenia 234.79 13.02 139 70800 11292 79662157
Dysarthria 226.69 13.02 290 70649 67332 79606117
Irritability 224.10 13.02 227 70712 40917 79632532
Arthralgia 223.77 13.02 115 70824 571688 79101761
Hypernatraemia 219.31 13.02 145 70794 14306 79659143
Muscle rigidity 219.08 13.02 164 70775 19718 79653731
Overdose 216.87 13.02 495 70444 183711 79489738
Dyspnoea 211.76 13.02 272 70667 856753 78816696
Delirium 210.12 13.02 314 70625 84313 79589136
Confusional state 205.72 13.02 686 70253 317311 79356138
Psychomotor hyperactivity 194.65 13.02 143 70796 16706 79656743
Delusion 180.73 13.02 148 70791 20275 79653174
Hyperreflexia 180.20 13.02 105 70834 8280 79665169
Mental status changes 178.58 13.02 257 70682 66702 79606747
Antipsychotic drug level below therapeutic 173.03 13.02 58 70881 1180 79672269
Myoclonus 168.05 13.02 162 70777 27498 79645951
Jaundice cholestatic 161.07 13.02 109 70830 11175 79662274
Disorientation 160.21 13.02 236 70703 62540 79610909
Somnolence 155.69 13.02 517 70422 238464 79434985
Neurotoxicity 154.85 13.02 167 70772 32351 79641098
Abnormal behaviour 154.40 13.02 176 70763 36245 79637204
Intentional overdose 150.08 13.02 307 70632 105653 79567796
Drug level increased 148.79 13.02 180 70759 39471 79633978
Infusion related reaction 148.27 13.02 16 70923 230221 79443228
Rheumatoid arthritis 146.47 13.02 10 70929 208460 79464989
Dystonia 144.68 13.02 133 70806 21266 79652183
Euphoric mood 143.30 13.02 88 70851 7638 79665811
Dyskinesia 134.50 13.02 182 70757 44591 79628858
Joint swelling 133.72 13.02 45 70894 288601 79384848
Polyuria 133.25 13.02 109 70830 14905 79658544
Schizoaffective disorder 128.27 13.02 54 70885 2098 79671351
Febrile neutropenia 128.06 13.02 25 70914 230974 79442475
Hypothyroidism 128 13.02 193 70746 52199 79621250
Anaemia 127.30 13.02 125 70814 444890 79228559
Disturbance in attention 123.91 13.02 187 70752 50614 79622835
Pleurothotonus 120.16 13.02 54 70885 2462 79670987
Synovitis 119.81 13.02 3 70936 150731 79522718
Hypersensitivity 119.53 13.02 42 70897 262197 79411252
Neutrophil count increased 119.46 13.02 139 70800 29257 79644192
Pruritus 118.56 13.02 106 70833 394542 79278907
Arthropathy 117.43 13.02 11 70928 177100 79496349
Delusion of grandeur 116.69 13.02 45 70894 1387 79672062
Cough 115.69 13.02 94 70845 366695 79306754
Weight increased 114.91 13.02 520 70419 276866 79396583
Treatment noncompliance 114.36 13.02 183 70756 52085 79621364
Swelling 112.90 13.02 27 70912 216684 79456765
Polydipsia 111.83 13.02 71 70868 6534 79666915
Peripheral swelling 111.70 13.02 50 70889 269567 79403882
Nasopharyngitis 110.11 13.02 44 70895 253837 79419612
Brugada syndrome 108.41 13.02 41 70898 1197 79672252
Rash 108.21 13.02 220 70719 578138 79095311
Pain in extremity 108.18 13.02 99 70840 364439 79309010
Depression 107.25 13.02 429 70510 216361 79457088
Paranoia 107.22 13.02 108 70831 19324 79654125
Depressed level of consciousness 106.23 13.02 253 70686 96399 79577050
Nephropathy 102.12 13.02 78 70861 9660 79663789
Bruxism 101.58 13.02 56 70883 3970 79669479
Malignant neoplasm progression 100.14 13.02 5 70934 135985 79537464
Mental disorder 99.78 13.02 131 70808 31171 79642278
Restlessness 97.92 13.02 160 70779 46332 79627117
Back pain 97.08 13.02 77 70862 304103 79369346
Electrocardiogram QT prolonged 96.54 13.02 234 70705 90152 79583297
Bipolar I disorder 96.31 13.02 44 70895 2085 79671364
Intentional self-injury 96.18 13.02 131 70808 32288 79641161
Systemic lupus erythematosus 94.11 13.02 3 70936 121146 79552303
Sinusitis 93.12 13.02 29 70910 195472 79477977
Myocarditis 92.06 13.02 105 70834 21628 79651821
Apathy 90.34 13.02 82 70857 12895 79660554
Cognitive disorder 90.13 13.02 195 70744 69731 79603718
Stomatitis 90.01 13.02 12 70927 146745 79526704
Leukocytosis 89.43 13.02 148 70791 43307 79630142
Clonus 88.03 13.02 62 70877 6778 79666671
White blood cell count increased 87.07 13.02 200 70739 74433 79599016
Priapism 85.30 13.02 52 70887 4453 79668996
Grandiosity 84.02 13.02 28 70911 559 79672890
Cogwheel rigidity 83.59 13.02 45 70894 3043 79670406
Interstitial lung disease 83.35 13.02 4 70935 112596 79560853
Libido increased 83.18 13.02 39 70900 1962 79671487
Leukopenia 82.94 13.02 260 70679 116253 79557196
Blood creatine phosphokinase increased 82.56 13.02 182 70757 65908 79607541
Affect lability 82.04 13.02 73 70866 11186 79662263
Speech disorder 80.92 13.02 161 70778 54284 79619165
Oppositional defiant disorder 80.38 13.02 26 70913 471 79672978
Infection 79.90 13.02 59 70880 241653 79431796
Arthritis 79.25 13.02 6 70933 114874 79558575
Logorrhoea 79.12 13.02 49 70890 4316 79669133
Depressed mood 78.94 13.02 149 70790 48331 79625118
Fatigue 78.76 13.02 495 70444 929232 78744217
Parathyroid tumour benign 78.57 13.02 29 70910 790 79672659
Anxiety 78.13 13.02 431 70508 248081 79425368
Lethargy 77.93 13.02 202 70737 81090 79592359
Hypercalcaemia 77.89 13.02 130 70809 38300 79635149
Pressure of speech 77.18 13.02 32 70907 1196 79672253
Atrial fibrillation 76.89 13.02 40 70899 197846 79475603
Mutism 76.88 13.02 39 70900 2333 79671116
General physical health deterioration 76.68 13.02 79 70860 275159 79398290
Homicidal ideation 76.16 13.02 44 70895 3413 79670036
Renal cyst 76.05 13.02 79 70860 14653 79658796
Drug intolerance 75.64 13.02 74 70865 264045 79409404
Total lung capacity increased 75.11 13.02 38 70901 2260 79671189
Coordination abnormal 73.93 13.02 84 70855 17228 79656221
Hyperprolactinaemia 73.57 13.02 48 70891 4628 79668821
Choreoathetosis 72.76 13.02 33 70906 1537 79671912
Glossodynia 72.42 13.02 5 70934 103332 79570117
Death 71.65 13.02 261 70678 566253 79107196
Sopor 71.41 13.02 115 70824 32895 79640554
Contraindicated product administered 70.44 13.02 26 70913 157512 79515937
Wound 70.06 13.02 10 70929 116169 79557280
Headache 69.10 13.02 323 70616 653449 79020000
Enuresis 68.85 13.02 40 70899 3136 79670313
Affective disorder 68.84 13.02 58 70881 8261 79665188
Withdrawal syndrome 68.54 13.02 101 70838 26753 79646696
Intentional product use issue 68.18 13.02 25 70914 152087 79521362
Chronic kidney disease 67.16 13.02 168 70771 65986 79607463
Urticaria 66.83 13.02 41 70898 185160 79488289
Decreased eye contact 66.30 13.02 26 70913 839 79672610
Hyperparathyroidism primary 65.93 13.02 22 70917 441 79673008
Thinking abnormal 65.13 13.02 69 70870 13092 79660357
Drug level above therapeutic 64.44 13.02 57 70882 8666 79664783
Altered state of consciousness 64.41 13.02 129 70810 43693 79629756
Abdominal pain upper 63.74 13.02 63 70876 223756 79449693
Hostility 63.47 13.02 34 70905 2276 79671173
Aphasia 63.30 13.02 133 70806 46599 79626850
Asthma-chronic obstructive pulmonary disease overlap syndrome 63.10 13.02 38 70901 3183 79670266
Disease progression 62.22 13.02 44 70895 184318 79489131
Body tinea 61.60 13.02 31 70908 1823 79671626
Poisoning 61.57 13.02 93 70846 25179 79648270
Increased appetite 61.42 13.02 64 70875 11914 79661535
Drooling 61.05 13.02 47 70892 5887 79667562
Camptocormia 60.90 13.02 21 70918 467 79672982
Blister 60.05 13.02 16 70923 119460 79553989
Sepsis 59.74 13.02 92 70847 269336 79404113
Insomnia 59.73 13.02 398 70541 244772 79428677
Cholelithiasis 59.08 13.02 139 70800 52525 79620924
Alopecia 58.32 13.02 72 70867 231283 79442166
Schizoaffective disorder bipolar type 57.49 13.02 17 70922 225 79673224
Abdominal pain 56.41 13.02 169 70770 389400 79284049
Poor quality sleep 55.90 13.02 84 70855 22638 79650811
Somatic symptom disorder 55.12 13.02 32 70907 2505 79670944
Stupor 54.99 13.02 47 70892 6825 79666624
Dystonic tremor 54.73 13.02 16 70923 203 79673246
Disinhibition 54.41 13.02 32 70907 2566 79670883
Encephalopathy 54.16 13.02 157 70782 67240 79606209
Impaired healing 54.14 13.02 7 70932 87648 79585801
Cardiac failure congestive 53.53 13.02 30 70909 142372 79531077
Anger 53.42 13.02 71 70868 17091 79656358
Pneumonia 52.98 13.02 357 70582 659889 79013560
Asthma 52.92 13.02 27 70912 135068 79538381
Therapeutic product effect decreased 52.84 13.02 41 70898 163822 79509627
Blood sodium increased 51.56 13.02 39 70900 4759 79668690
Gastrointestinal haemorrhage 51.51 13.02 34 70905 147685 79525764
Psoriatic arthropathy 51.26 13.02 5 70934 77994 79595455
Diarrhoea 51.16 13.02 519 70420 879970 78793479
Septic shock 50.46 13.02 23 70916 122778 79550671
Bronchitis 49.86 13.02 27 70912 130617 79542832
Hepatotoxicity 49.61 13.02 128 70811 51224 79622225
Anticholinergic syndrome 49.44 13.02 34 70905 3577 79669872
Cerebellar syndrome 49.08 13.02 40 70899 5440 79668009
Abulia 49.05 13.02 22 70917 998 79672451
Distractibility 48.81 13.02 20 70919 725 79672724
Neurological symptom 48.79 13.02 49 70890 8734 79664715
Drug reaction with eosinophilia and systemic symptoms 47.21 13.02 145 70794 64099 79609350
Thrombocytopenia 46.88 13.02 104 70835 265155 79408294
Ascites 46.75 13.02 6 70933 75556 79597893
Memory impairment 46.56 13.02 210 70729 111524 79561925
Resting tremor 46.37 13.02 24 70915 1497 79671952
Cerebellar atrophy 46.33 13.02 22 70917 1139 79672310
Abdominal discomfort 46.23 13.02 96 70843 250631 79422818
Major depression 46.07 13.02 48 70891 8932 79664517
Electrocardiogram T wave abnormal 46.07 13.02 33 70906 3705 79669744
Oxygen saturation decreased 45.95 13.02 29 70910 129018 79544431
Musculoskeletal pain 45.56 13.02 17 70922 102337 79571112
Fibromyalgia 45.41 13.02 3 70936 64337 79609112
Electrocardiogram QRS complex prolonged 45.30 13.02 52 70887 10781 79662668
Inhibitory drug interaction 45.23 13.02 35 70904 4418 79669031
Seizure 45.03 13.02 305 70634 188529 79484920
Trismus 44.99 13.02 38 70901 5429 79668020
Mental impairment 44.88 13.02 69 70870 18967 79654482
Injection site erythema 44.29 13.02 8 70931 78189 79595260
Product tampering 44.19 13.02 16 70923 412 79673037
Gastrointestinal disorder 44.15 13.02 27 70912 122178 79551271
Renal oncocytoma 43.99 13.02 11 70928 73 79673376
Action tremor 43.48 13.02 16 70923 432 79673017
Osteoarthritis 43.29 13.02 12 70927 87297 79586152
Bradykinesia 43.09 13.02 44 70895 7999 79665450
Cardio-respiratory arrest 43.03 13.02 201 70738 108309 79565140
Metabolic syndrome 42.80 13.02 28 70911 2712 79670737
Malaise 42.77 13.02 258 70681 489611 79183838
Failure to suspend medication 42.60 13.02 16 70923 458 79672991
Productive cough 42.22 13.02 13 70926 88318 79585131
Pericarditis 42.09 13.02 20 70919 104216 79569233
Adulterated product 41.99 13.02 14 70925 280 79673169
Blunted affect 41.86 13.02 16 70923 481 79672968
Blood prolactin increased 41.77 13.02 32 70907 3979 79669470
Postural tremor 41.71 13.02 18 70921 744 79672705
Infection susceptibility increased 41.66 13.02 31 70908 3690 79669759
Depressive symptom 41.63 13.02 39 70900 6384 79667065
Claustrophobia 41.51 13.02 21 70918 1249 79672200
Electrocardiogram T wave inversion 41.48 13.02 36 70903 5336 79668113
Muscle twitching 41.41 13.02 77 70862 24687 79648762
Mood swings 41.29 13.02 68 70871 19812 79653637
Personality disorder 41.15 13.02 38 70901 6108 79667341
Thrombosis 40.88 13.02 12 70927 84088 79589361
Myocardial infarction 40.67 13.02 63 70876 184066 79489383
Pancytopenia 40.28 13.02 53 70886 165692 79507757
Weight decreased 40.13 13.02 171 70768 355027 79318422
Soft tissue injury 40.12 13.02 23 70916 1758 79671691
Visuospatial deficit 39.78 13.02 9 70930 36 79673413
Discomfort 39.78 13.02 32 70907 125585 79547864
Pneumonitis 39.74 13.02 4 70935 60856 79612593
Drug hypersensitivity 39.52 13.02 135 70804 298781 79374668
Haemodialysis 38.89 13.02 63 70876 18105 79655344
Hallucination 38.64 13.02 165 70774 85580 79587869
Psychiatric symptom 38.62 13.02 39 70900 6996 79666453
Decreased appetite 38.59 13.02 165 70774 342253 79331196
Oculogyric crisis 38.55 13.02 27 70912 2925 79670524
Behaviour disorder 38.38 13.02 37 70902 6276 79667173
Chest pain 38.34 13.02 126 70813 282178 79391271
Erythema 38.27 13.02 89 70850 223201 79450248
Drug withdrawal syndrome 38.25 13.02 91 70848 34627 79638822
Persecutory delusion 38.11 13.02 33 70906 4876 79668573
Psychiatric decompensation 37.77 13.02 30 70909 3933 79669516
Glucose tolerance impaired 37.57 13.02 41 70898 8043 79665406
Electroencephalogram abnormal 37.16 13.02 34 70905 5400 79668049
Hypothermia 37.13 13.02 70 70869 22676 79650773
Anaphylactic reaction 37.12 13.02 14 70925 83729 79589720
Hyperthyroidism 37.07 13.02 69 70870 22140 79651309
Feelings of worthlessness 36.78 13.02 15 70924 537 79672912
Electroconvulsive therapy 36.64 13.02 10 70929 97 79673352
Goitre 36.61 13.02 34 70905 5505 79667944
Lung disorder 36.50 13.02 13 70926 80544 79592905
Flight of ideas 36.45 13.02 17 70922 845 79672604
Suspected suicide 36.42 13.02 46 70893 10530 79662919
Sleep-related eating disorder 36.26 13.02 16 70923 698 79672751
Cardiac failure 36.13 13.02 51 70888 154791 79518658
Hypertonia 35.93 13.02 38 70901 7194 79666255
Asterixis 35.91 13.02 25 70914 2682 79670767
Self-injurious ideation 35.66 13.02 28 70911 3610 79669839
Galactorrhoea 35.60 13.02 28 70911 3618 79669831
Nasal polyps 35.52 13.02 38 70901 7289 79666160
Hyperthermia 35.19 13.02 60 70879 17977 79655472
Respiratory arrest 35.17 13.02 122 70817 57428 79616021
Melaena 34.98 13.02 6 70933 60884 79612565
Muscle contractions involuntary 34.81 13.02 28 70911 3737 79669712
Social avoidant behaviour 34.65 13.02 31 70908 4783 79668666
Epistaxis 34.57 13.02 29 70910 111486 79561963
Haemorrhage 34.52 13.02 19 70920 91099 79582350
Impulsive behaviour 34.36 13.02 25 70914 2875 79670574
Mood altered 34.34 13.02 59 70880 17788 79655661
Acute psychosis 34.29 13.02 29 70910 4151 79669298
Blood bilirubin increased 34.25 13.02 133 70806 66099 79607350
Post-traumatic neck syndrome 34.18 13.02 22 70917 2072 79671377
Blood thyroid stimulating hormone decreased 33.81 13.02 33 70906 5683 79667766
Blood pressure fluctuation 33.72 13.02 9 70930 67136 79606313
Plasma cell myeloma 33.50 13.02 4 70935 53255 79620194
Hyperkinesia 33.42 13.02 24 70915 2705 79670744
Feeling guilty 33.27 13.02 16 70923 852 79672597
Sarcoidosis 33.17 13.02 39 70900 8296 79665153
Electrocardiogram abnormal 33.09 13.02 56 70883 16681 79656768
Bradyphrenia 33.08 13.02 44 70895 10596 79662853
International normalised ratio increased 33.08 13.02 17 70922 84704 79588745
Lower respiratory tract infection 32.77 13.02 40 70899 129180 79544269
Nodal rhythm 32.62 13.02 25 70914 3110 79670339
Therapeutic product effect variable 32.53 13.02 21 70918 1988 79671461
Dysphemia 32.40 13.02 26 70913 3458 79669991
Injection site pain 32.08 13.02 41 70898 129797 79543652
Speech sound disorder 32.00 13.02 8 70931 53 79673396
Gait disturbance 31.85 13.02 303 70636 207203 79466246
Mobility decreased 31.85 13.02 37 70902 122138 79551311
Pleural effusion 31.79 13.02 50 70889 145212 79528237
Dyspnoea exertional 31.78 13.02 19 70920 87054 79586395
Rhinalgia 31.73 13.02 22 70917 2345 79671104
Autonomic nervous system imbalance 31.72 13.02 29 70910 4601 79668848
Rhinorrhoea 31.64 13.02 14 70925 76060 79597389
Oncocytoma 31.14 13.02 7 70932 27 79673422
Echolalia 31.11 13.02 12 70927 370 79673079
Antipsychotic drug level decreased 30.81 13.02 17 70922 1207 79672242
Inflammation 30.80 13.02 23 70916 93730 79579719
Cerebrovascular accident 30.73 13.02 57 70882 155235 79518214
Agranulocytosis 30.66 13.02 99 70840 44931 79628518
Amenorrhoea 30.62 13.02 36 70903 7656 79665793
Restless legs syndrome 30.55 13.02 60 70879 20032 79653417
Sternal fracture 30.41 13.02 22 70917 2508 79670941
Papillary thyroid cancer 29.98 13.02 22 70917 2564 79670885
Influenza 29.92 13.02 43 70896 129563 79543886
Judgement impaired 29.85 13.02 17 70922 1283 79672166
Urinary incontinence 29.74 13.02 92 70847 40817 79632632
Neutrophilia 29.66 13.02 36 70903 7915 79665534
Product use issue 29.63 13.02 92 70847 209730 79463719
Haemoglobin decreased 29.56 13.02 100 70839 222019 79451430
Tachycardia 29.51 13.02 264 70675 177504 79495945
Blood creatinine increased 29.29 13.02 237 70702 154820 79518629
Acute myocardial infarction 29.27 13.02 16 70923 77020 79596429
Dysphoria 29.26 13.02 28 70911 4706 79668743
Convulsive threshold lowered 29.04 13.02 15 70924 932 79672517
Hyperhidrosis 28.86 13.02 232 70707 151260 79522189
Cardiac hypertrophy 28.79 13.02 18 70921 1612 79671837
Adams-Stokes syndrome 28.63 13.02 9 70930 148 79673301
Otospondylomegaepiphyseal dysplasia 28.60 13.02 7 70932 42 79673407
Hypokalaemia 28.39 13.02 53 70886 143987 79529462
Pyrexia 28.38 13.02 429 70510 678280 78995169
Bundle branch block right 28.25 13.02 42 70897 11209 79662240
Rebound psychosis 27.82 13.02 11 70928 363 79673086
Patient restraint 27.70 13.02 8 70931 97 79673352
Treatment failure 27.59 13.02 70 70869 170416 79503033
Lymphocyte count abnormal 27.57 13.02 17 70922 1486 79671963
Long QT syndrome 27.32 13.02 30 70909 5925 79667524
Tachyphrenia 27.11 13.02 19 70920 2061 79671388
Hallucination, visual 27.02 13.02 77 70862 32652 79640797
Bone pain 27.01 13.02 8 70931 55734 79617715
Upper respiratory tract infection 26.70 13.02 25 70914 91143 79582306
Upper gastrointestinal haemorrhage 26.30 13.02 3 70936 41377 79632072
Parkinsonian gait 26.18 13.02 14 70925 934 79672515
Wrong patient received product 26.09 13.02 26 70913 4592 79668857
Hereditary ataxia 25.95 13.02 6 70933 27 79673422
Paraesthesia 25.83 13.02 76 70863 176247 79497202
Skin ulcer 25.82 13.02 8 70931 54142 79619307
Acquired cystic kidney disease 25.73 13.02 7 70932 67 79673382
Hyporeflexia 25.73 13.02 23 70916 3545 79669904
Knee arthroplasty 25.43 13.02 4 70935 43244 79630205
Myelosuppression 25.41 13.02 3 70936 40293 79633156
Osteonecrosis of jaw 25.41 13.02 4 70935 43222 79630227
Acute kidney injury 25.13 13.02 622 70317 518782 79154667
Diabetic coma 25.13 13.02 15 70924 1236 79672213
Flat affect 25.11 13.02 18 70921 2023 79671426
Cerebral haemorrhage 24.97 13.02 10 70929 57663 79615786
Gaze palsy 24.96 13.02 21 70918 2984 79670465
Cystitis 24.77 13.02 8 70931 52724 79620725
Delusion of reference 24.68 13.02 8 70931 146 79673303
Substance abuse 24.60 13.02 38 70901 10488 79662961
Haematochezia 24.55 13.02 25 70914 87620 79585829
Defect conduction intraventricular 24.46 13.02 11 70928 502 79672947
Haematoma 24.37 13.02 8 70931 52187 79621262
Coronary artery disease 24.30 13.02 14 70925 65460 79607989
Injection site swelling 24.27 13.02 6 70933 47126 79626323
Nephropathy toxic 24.11 13.02 55 70884 20364 79653085
Ideas of reference 23.90 13.02 8 70931 162 79673287
Staphylococcal infection 23.81 13.02 11 70928 58284 79615165
Haemoptysis 23.77 13.02 10 70929 55989 79617460
Chest discomfort 23.66 13.02 55 70884 137989 79535460
Neuropathy peripheral 23.66 13.02 57 70882 141248 79532201
Coma 23.63 13.02 162 70777 100487 79572962
Rhabdomyolysis 23.63 13.02 165 70774 102966 79570483
Hyperammonaemic encephalopathy 23.53 13.02 25 70914 4757 79668692
Nystagmus 23.49 13.02 36 70903 9868 79663581
Sinus arrest 23.49 13.02 22 70917 3600 79669849
Muscle injury 23.47 13.02 7 70932 48554 79624895
Sluggishness 23.29 13.02 29 70910 6543 79666906
Antipsychotic drug level 23.21 13.02 5 70934 15 79673434
Balance disorder 23.14 13.02 159 70780 98698 79574751
Hyperammonaemia 23.11 13.02 38 70901 11055 79662394
Rhinitis allergic 22.87 13.02 40 70899 12229 79661220
Metabolic encephalopathy 22.76 13.02 34 70905 9113 79664336
Hyperkalaemia 22.62 13.02 42 70897 114356 79559093
Blood pressure systolic increased 22.57 13.02 16 70923 66970 79606479
Antidepressant drug level increased 22.54 13.02 10 70929 442 79673007
Thyroiditis 22.53 13.02 24 70915 4581 79668868
Sexual dysfunction 22.46 13.02 31 70908 7732 79665717
Angina pectoris 22.34 13.02 9 70930 51723 79621726
Muscle spasms 22.34 13.02 80 70859 174650 79498799
Hypoxia 22.15 13.02 36 70903 103207 79570242
Oromandibular dystonia 22.08 13.02 13 70926 1045 79672404
Obesity 21.93 13.02 75 70864 35050 79638399
Dry skin 21.92 13.02 17 70922 67978 79605471
Drug level decreased 21.88 13.02 43 70896 14359 79659090
Hallucination, olfactory 21.81 13.02 10 70929 478 79672971
Eosinophilia 21.78 13.02 89 70850 45256 79628193
Negativism 21.76 13.02 12 70927 851 79672598
Status epilepticus 21.74 13.02 60 70879 24981 79648468
Colitis 21.59 13.02 20 70919 73287 79600162
Ileus paralytic 21.47 13.02 34 70905 9586 79663863
Clear cell renal cell carcinoma 21.39 13.02 18 70921 2558 79670891
Maternal exposure during pregnancy 21.37 13.02 57 70882 136481 79536968
High-grade B-cell lymphoma 21.23 13.02 7 70932 135 79673314
Thought blocking 21.20 13.02 8 70931 232 79673217
Consciousness fluctuating 21.15 13.02 16 70923 1953 79671496
Rectal haemorrhage 21.10 13.02 22 70917 76278 79597171
CSWS syndrome 21.03 13.02 5 70934 26 79673423
Hepatocellular injury 21.02 13.02 8 70931 47585 79625864
Localised infection 20.94 13.02 4 70935 37571 79635878
Muscle contracture 20.93 13.02 17 70922 2300 79671149
Ear infection 20.67 13.02 3 70936 34429 79639020
Fluid retention 20.61 13.02 19 70920 69790 79603659
Unmasking of previously unidentified disease 20.53 13.02 16 70923 2041 79671408
Lactate pyruvate ratio increased 20.32 13.02 6 70933 79 79673370
Mydriasis 20.25 13.02 47 70892 17596 79655853
Cardiac murmur 20.23 13.02 44 70895 15780 79657669
Cerebral atrophy 20.07 13.02 30 70909 8045 79665404
Oropharyngeal pain 20.02 13.02 42 70897 109311 79564138
Diverticulitis 19.83 13.02 8 70931 45928 79627521
Thyrotoxic crisis 19.76 13.02 13 70926 1271 79672178
Injection site bruising 19.65 13.02 6 70933 40996 79632453
Off label use 19.53 13.02 637 70302 906578 78766871
Irritable bowel syndrome 19.52 13.02 16 70923 62225 79611224
Drug abuse 19.50 13.02 226 70713 162465 79510984
Brain injury 19.49 13.02 36 70903 11481 79661968
Ill-defined disorder 19.37 13.02 18 70921 65857 79607592
Full blood count abnormal 19.26 13.02 6 70933 40468 79632981
Conduction disorder 19.04 13.02 19 70920 3360 79670089
Staring 18.97 13.02 17 70922 2628 79670821
Eosinophil count decreased 18.96 13.02 19 70920 3377 79670072
Myoclonic epilepsy 18.96 13.02 15 70924 1955 79671494
Blood triglycerides increased 18.85 13.02 51 70888 20989 79652460
Basal cell carcinoma 18.78 13.02 5 70934 37370 79636079
Colitis ulcerative 18.73 13.02 4 70935 34738 79638711
Sinus bradycardia 18.56 13.02 57 70882 25190 79648259
Blood thyroid stimulating hormone increased 18.55 13.02 32 70907 9676 79663773
Nausea 18.55 13.02 681 70258 956515 78716934
Fungal infection 18.46 13.02 7 70932 41741 79631708
Torticollis 18.44 13.02 16 70923 2371 79671078
Sleep disorder 18.42 13.02 135 70804 85542 79587907
Histrionic personality disorder 18.37 13.02 5 70934 48 79673401
Differential white blood cell count abnormal 18.26 13.02 15 70924 2062 79671387
Osteonecrosis 18.00 13.02 3 70936 31092 79642357
Hypophagia 17.95 13.02 84 70855 45283 79628166
Femur fracture 17.92 13.02 6 70933 38646 79634803
Throat irritation 17.89 13.02 7 70932 40939 79632510
Secondary tic 17.88 13.02 4 70935 15 79673434
Intention tremor 17.79 13.02 10 70929 736 79672713
Sexually inappropriate behaviour 17.78 13.02 9 70930 536 79672913
Angioedema 17.77 13.02 25 70914 76010 79597439
Hallucinations, mixed 17.68 13.02 26 70913 6873 79666576
Decreased interest 17.62 13.02 19 70920 3678 79669771
Prostate cancer 17.59 13.02 4 70935 33264 79640185
Blood citric acid increased 17.43 13.02 5 70934 59 79673390
Social anxiety disorder 17.38 13.02 9 70930 562 79672887
Bacteraemia 17.25 13.02 4 70935 32820 79640629
Pulse abnormal 17.20 13.02 18 70921 3366 79670083
COVID-19 17.11 13.02 77 70862 157597 79515852
Myalgia 17.10 13.02 96 70843 185545 79487904
Body mass index increased 17.08 13.02 14 70925 1919 79671530
Merycism 17.00 13.02 7 70932 257 79673192
Incoherent 16.91 13.02 27 70912 7665 79665784
Sinus node dysfunction 16.88 13.02 27 70912 7674 79665775
Movement disorder 16.84 13.02 58 70881 27201 79646248
Night sweats 16.83 13.02 13 70926 52082 79621367
Haematuria 16.73 13.02 22 70917 68814 79604635
Dry eye 16.66 13.02 6 70933 36925 79636524
Bradycardia 16.55 13.02 189 70750 135368 79538081
Gestational diabetes 16.54 13.02 24 70915 6269 79667180
Gambling disorder 16.50 13.02 14 70925 2012 79671437
Activation syndrome 16.48 13.02 7 70932 278 79673171
Concussion 16.46 13.02 30 70909 9473 79663976
Bipolar II disorder 16.34 13.02 8 70931 443 79673006
Nephrolithiasis 16.34 13.02 14 70925 53277 79620172
Limbic encephalitis 16.31 13.02 10 70929 865 79672584
Sleep apnoea syndrome 16.28 13.02 70 70869 36408 79637041
Atrioventricular block first degree 16.27 13.02 35 70904 12456 79660993
Oedema peripheral 16.13 13.02 145 70794 252143 79421306
Mouth ulceration 16.07 13.02 7 70932 38387 79635062
Antidepressant drug level above therapeutic 15.95 13.02 9 70930 667 79672782
Metabolic disorder 15.94 13.02 29 70910 9141 79664308
Dyslipidaemia 15.62 13.02 33 70906 11600 79661849
Pain in jaw 15.57 13.02 11 70928 46140 79627309
Blood pressure increased 15.55 13.02 117 70822 211243 79462206
Autoimmune thyroiditis 15.52 13.02 19 70920 4214 79669235
Injection site haemorrhage 15.46 13.02 3 70936 27867 79645582
Hepatic failure 15.46 13.02 19 70920 61193 79612256
Tic 15.39 13.02 16 70923 2970 79670479
Neoplasm progression 15.34 13.02 14 70925 51668 79621781
Essential tremor 15.31 13.02 12 70927 1543 79671906
Urine output increased 15.20 13.02 14 70925 2242 79671207
Cerebral amyloid angiopathy 15.16 13.02 7 70932 340 79673109
Cerebellar ataxia 15.09 13.02 13 70926 1908 79671541
Refusal of treatment by patient 15.09 13.02 28 70911 8963 79664486
Oscillopsia 15.06 13.02 6 70933 202 79673247
Generalised tonic-clonic seizure 15.02 13.02 78 70861 43832 79629617
Impaired work ability 14.99 13.02 45 70894 19636 79653813
Water intoxication 14.82 13.02 9 70930 765 79672684
Cyclothymic disorder 14.79 13.02 6 70933 212 79673237
Eye movement disorder 14.78 13.02 26 70913 7985 79665464
Device related infection 14.75 13.02 6 70933 34288 79639161
Thyroid function test abnormal 14.75 13.02 16 70923 3118 79670331
Parasomnia 14.70 13.02 8 70931 553 79672896
Platelet count decreased 14.69 13.02 107 70832 194557 79478892
Glomerulonephritis minimal lesion 14.68 13.02 9 70930 778 79672671
Flatulence 14.66 13.02 10 70929 42714 79630735
Clostridium difficile infection 14.64 13.02 10 70929 42675 79630774
Diabetic hyperosmolar coma 14.58 13.02 9 70930 788 79672661
Human herpesvirus 6 infection reactivation 14.51 13.02 8 70931 567 79672882
Hypersexuality 14.49 13.02 12 70927 1668 79671781
Obstructive airways disorder 14.38 13.02 5 70934 31454 79641995
Pulmonary mass 14.37 13.02 4 70935 29030 79644419
Suicidal behaviour 14.28 13.02 16 70923 3231 79670218
Bursitis 14.28 13.02 7 70932 35837 79637612
Polyhydramnios 14.25 13.02 12 70927 1708 79671741
Apraxia 14.13 13.02 15 70924 2852 79670597
Hypovolaemia 14 13.02 41 70898 17650 79655799
Acute myeloid leukaemia 13.96 13.02 5 70934 30880 79642569
Toxic cardiomyopathy 13.95 13.02 7 70932 409 79673040
Dysphagia 13.90 13.02 168 70771 121968 79551481
Hip fracture 13.87 13.02 5 70934 30756 79642693
Dialysis 13.86 13.02 42 70897 18420 79655029
Accidental death 13.73 13.02 18 70921 4273 79669176
Fluid intake reduced 13.72 13.02 22 70917 6266 79667183
Toxic encephalopathy 13.71 13.02 31 70908 11409 79662040
Posture abnormal 13.61 13.02 17 70922 3849 79669600
Persistent depressive disorder 13.40 13.02 10 70929 1195 79672254
Ulcer 13.30 13.02 5 70934 29967 79643482
Waxy flexibility 13.28 13.02 6 70933 277 79673172
Amimia 13.19 13.02 4 70935 58 79673391
Stereotypy 13.18 13.02 9 70930 936 79672513
Tubulointerstitial nephritis 13.13 13.02 68 70871 38167 79635282
Psychotic disorder due to a general medical condition 13.12 13.02 6 70933 285 79673164
Psychotic symptom 13.10 13.02 14 70925 2683 79670766
Mucosal dryness 13.09 13.02 16 70923 3543 79669906
Small intestinal obstruction 13.05 13.02 4 70935 27268 79646181
Impaired self-care 13.05 13.02 14 70925 2693 79670756
Candida infection 13.04 13.02 9 70930 38205 79635244

FDA Adverse Event Reporting System (Pediatric)

None

Pharmacologic Action:

SourceCodeDescription
ATC N05AN01 NERVOUS SYSTEM
PSYCHOLEPTICS
ANTIPSYCHOTICS
Lithium
CHEBI has role CHEBI:35469 antidepressants
MeSH PA D000928 Antidepressive Agents
MeSH PA D018692 Antimanic Agents
MeSH PA D002491 Central Nervous System Agents
MeSH PA D002492 Central Nervous System Depressants
MeSH PA D004791 Enzyme Inhibitors
MeSH PA D011619 Psychotropic Drugs
MeSH PA D014149 Tranquilizing Agents

Drug Use | Suggest Off label Use Form| |View source of the data|

DiseaseRelationSNOMED_IDDOID
Bipolar disorder indication 13746004 DOID:3312
Bipolar disorder in remission indication 85248005
Bipolar affective disorder, current episode manic indication 191618007
Vascular headache off-label use 128187005
Bipolar affective disorder, current episode depression off-label use 191627008 DOID:3312
Cluster Headache Prevention off-label use
Rapid Cycling Bipolar Affective Disorder off-label use
Psoriasis contraindication 9014002 DOID:8893
Diabetes insipidus contraindication 15771004 DOID:9409
Polyuria contraindication 28442001
Hypothyroidism contraindication 40930008 DOID:1459
Conduction disorder of the heart contraindication 44808001
Chronic heart failure contraindication 48447003
Acute infectious disease contraindication 63171007
Hyponatremia contraindication 89627008
Kidney disease contraindication 90708001 DOID:557
Organic mental disorder contraindication 111479008
Plaque psoriasis contraindication 200965009
Pregnancy, function contraindication 289908002
Breastfeeding (mother) contraindication 413712001
Severe dehydration contraindication 450316000
Lithium Toxicity contraindication




🐶 Veterinary Drug Use

None

🐶 Veterinary products

None

Acid dissociation constants calculated using MoKa v3.0.0

None

Orange Book patent data (new drug applications)

None

Orange Book exclusivity data (new drug applications)

None

Bioactivity Summary:

TargetClassPharosUniProtActionTypeActivity value
(-log[M])
Mechanism
action
Bioact sourceMoA source
Glycogen synthase kinase-3 Kinase INHIBITOR CHEMBL CHEMBL
Inositol-1(or 4)-monophosphatase 1 Enzyme INHIBITOR CHEMBL CHEMBL

External reference:

IDSource
D04749 KEGG_DRUG
4018009 VUID
N0000179333 NUI
4018008 VANDF
4018009 VANDF
4019803 VANDF
CHEBI:64735 CHEBI
CHEBI:30145 CHEBI
CHEMBL1201170 ChEMBL_ID
CHEMBL2103738 ChEMBL_ID
CHEMBL1200826 ChEMBL_ID
C070669 MESH_SUPPLEMENTAL_RECORD_UI
DB14507 DRUGBANK_ID
5Z6E9K79YV UNII
DB14509 DRUGBANK_ID
203056 RXNORM
1994 MMSL
2001 MMSL
4987 MMSL
d00061 MMSL
001532 NDDF
001534 NDDF
17805003 SNOMEDCT_US
321719003 SNOMEDCT_US
387098001 SNOMEDCT_US
85899009 SNOMEDCT_US
C0125997 UMLSCUI
D016651 MESH_DESCRIPTOR_UI
C0023870 UMLSCUI
CHEMBL2146126 ChEMBL_ID
13520 PUBCHEM_CID
6080-58-6 SECONDARY_CAS_RN
7439-93-2 SECONDARY_CAS_RN
3028194 PUBCHEM_CID
D008094 MESH_DESCRIPTOR_UI
9FN79X2M3F UNII

Pharmaceutical products:

ProductCategoryIngredientsNDCFormQuantityRouteMarketingLabel
Lithium HUMAN PRESCRIPTION DRUG LABEL 1 0054-3527 SOLUTION 8 meq ORAL NDA 26 sections
Lithium HUMAN PRESCRIPTION DRUG LABEL 1 0054-3527 SOLUTION 8 meq ORAL NDA 26 sections
Lithium HUMAN PRESCRIPTION DRUG LABEL 1 0054-3527 SOLUTION 8 meq ORAL NDA 26 sections
Lithium HUMAN PRESCRIPTION DRUG LABEL 1 68094-757 SOLUTION 8 meq ORAL NDA 27 sections
Lithium HUMAN PRESCRIPTION DRUG LABEL 1 72888-172 SOLUTION 8 meq ORAL ANDA 26 sections