lithium citrate 🐶 Veterinary Use | Indications/Contra | FAERs-F | FAERs-M | Orange Bk | PK/Tox | Related Drugs | BioActivity |

Stem definitionDrug idCAS RN
4512 919-16-4

Description:

MoleculeDescription

Synonyms:

  • lithium citrate
  • trilithium citrate
  • lithonate
  • lithium citrate hydrate
  • Molecular weight: 209.92
  • Formula: C6H5Li3O7
  • CLOGP:
  • LIPINSKI: None
  • HAC: None
  • HDO: None
  • TPSA: 140.62
  • ALOGS:
  • ROTB: None

Drug dosage:

DoseUnitRoute
24 mmol O

ADMET properties:

None

Predicted pharmacokinetic/toxicological properties (PK-AZ):

None

Approvals:

DateAgencyCompanyOrphan
Dec. 23, 1980 FDA ROXANE

FDA Adverse Event Reporting System (Female)

MedDRA adverse event termLikelihood ratioLikelihood ratio thresholdPatients taking drug having adverse eventPatients taking drug not having adverse eventPatients not taking drug having adverse eventPatients not taking drug not having adverse event
Toxicity to various agents 1379.22 17.68 1061 36882 286785 90303719
Schizophrenia 746.66 17.68 268 37675 14646 90575858
Nephrogenic diabetes insipidus 661.15 17.68 137 37806 833 90589671
Hypomania 616.89 17.68 204 37739 8693 90581811
Neuroleptic malignant syndrome 585.73 17.68 225 37718 14871 90575633
Tremor 546.55 17.68 477 37466 152696 90437808
Mania 521.24 17.68 203 37740 13921 90576583
Psychotic disorder 510.40 17.68 253 37690 30977 90559527
Drug interaction 473.37 17.68 580 37363 275873 90314631
Completed suicide 414.37 17.68 399 37544 144659 90445845
Jaundice cholestatic 387.08 17.68 149 37794 9894 90580610
Suicidal ideation 359.87 17.68 276 37667 73579 90516925
Catatonia 357.19 17.68 123 37820 5933 90584571
Cholelithiasis 311.56 17.68 221 37722 52285 90538219
Antipsychotic drug level increased 295.73 17.68 95 37848 3684 90586820
Extrapyramidal disorder 290.00 17.68 140 37803 16163 90574341
Sedation 274.86 17.68 198 37745 47973 90542531
Ataxia 270.70 17.68 138 37805 17904 90572600
Hyperparathyroidism 253.41 17.68 82 37861 3255 90587249
Suicide attempt 235.29 17.68 218 37725 75181 90515323
Asthma-chronic obstructive pulmonary disease overlap syndrome 229.99 17.68 84 37859 4815 90585689
Total lung capacity increased 227.97 17.68 84 37859 4937 90585567
Akathisia 220.40 17.68 103 37840 11056 90579448
Serotonin syndrome 216.73 17.68 156 37787 37731 90552773
Hepatotoxicity 200.89 17.68 161 37782 45681 90544823
Blood bilirubin increased 199.77 17.68 157 37786 43313 90547191
Bipolar disorder 193.27 17.68 88 37855 8897 90581607
Tardive dyskinesia 188.77 17.68 92 37851 10838 90579666
Agitation 180.89 17.68 179 37764 66919 90523585
Pleurothotonus 179.79 17.68 51 37892 1284 90589220
Nasal polyps 168.39 17.68 85 37858 10795 90579709
Sarcoidosis 166.99 17.68 84 37859 10589 90579915
Obsessive-compulsive disorder 159.99 17.68 63 37880 4441 90586063
Intentional overdose 157.03 17.68 195 37748 93639 90496865
Hypernatraemia 156.09 17.68 77 37866 9310 90581194
Diabetes insipidus 150.49 17.68 55 37888 3157 90587347
Somnolence 150.29 17.68 294 37649 208790 90381714
Irritability 149.36 17.68 122 37821 35540 90554964
Pain 141.42 17.68 126 37817 996215 89594289
Cardiac murmur 137.49 17.68 89 37854 18105 90572399
Infusion related reaction 136.26 17.68 10 37933 416770 90173734
Salivary hypersecretion 134.78 17.68 69 37874 9023 90581481
Parkinsonism 134.68 17.68 80 37863 13985 90576519
Rhinitis allergic 134 17.68 85 37858 16700 90573804
Aggression 126.14 17.68 98 37845 26570 90563934
Rheumatoid arthritis 123.55 17.68 7 37936 362607 90227897
Disorientation 123.17 17.68 120 37823 43994 90546510
Arthropathy 121.99 17.68 8 37935 366234 90224270
Nasopharyngitis 119.31 17.68 15 37928 407089 90183415
Myoclonus 119.01 17.68 83 37860 19085 90571419
Overdose 115.99 17.68 224 37719 157485 90433019
Joint swelling 113.29 17.68 35 37908 503265 90087239
Antipsychotic drug level above therapeutic 113.25 17.68 36 37907 1348 90589156
Arthralgia 110.86 17.68 98 37845 778424 89812080
Bronchiectasis 109.85 17.68 84 37859 22246 90568258
Libido increased 108.99 17.68 37 37906 1707 90588797
Hypersensitivity 107.14 17.68 29 37914 454648 90135856
Hyperprolactinaemia 106.82 17.68 50 37893 5383 90585121
Muscle rigidity 105.67 17.68 69 37874 14240 90576264
Alopecia 105.18 17.68 38 37905 495033 90095471
Rash 104.27 17.68 108 37835 795992 89794512
Dysarthria 102.17 17.68 120 37823 54362 90536142
Swelling 102.03 17.68 25 37918 419033 90171471
Intentional self-injury 101.62 17.68 90 37853 29244 90561260
Paranoia 99.64 17.68 64 37879 12844 90577660
Stomatitis 97.73 17.68 4 37939 274694 90315810
Sinusitis 97.27 17.68 14 37929 343074 90247430
Hyperreflexia 97.17 17.68 50 37893 6607 90583897
Drug level increased 95.82 17.68 85 37858 27677 90562827
Peripheral swelling 94.25 17.68 28 37915 413078 90177426
Hostility 92.14 17.68 35 37908 2238 90588266
Somatic symptom disorder 91.10 17.68 39 37904 3402 90587102
Encephalopathy 89.93 17.68 104 37839 46340 90544164
Soft tissue injury 87.65 17.68 33 37910 2059 90588445
Lung neoplasm malignant 87.14 17.68 76 37867 24197 90566307
Camptocormia 87.13 17.68 21 37922 272 90590232
Mental disorder 86.65 17.68 86 37857 32232 90558272
Mental status changes 86.43 17.68 100 37843 44579 90545925
Oculogyric crisis 85.69 17.68 34 37909 2445 90588059
Schizoaffective disorder 84.91 17.68 42 37901 5105 90585399
Hypercalcaemia 84.28 17.68 87 37856 34153 90556351
Bipolar I disorder 84.18 17.68 32 37911 2050 90588454
Drug abuse 83.89 17.68 135 37808 82212 90508292
Pruritus 82.12 17.68 64 37879 541461 90049043
Post-traumatic neck syndrome 78.33 17.68 32 37911 2482 90588022
Dyspnoea 78.33 17.68 157 37786 880798 89709706
Sternal fracture 77.35 17.68 33 37910 2854 90587650
Disturbance in attention 77.32 17.68 97 37846 47012 90543492
Contraindicated product administered 76.16 17.68 20 37923 320119 90270385
Psoriatic arthropathy 75.95 17.68 5 37938 228330 90362174
Hypothyroidism 75.67 17.68 102 37841 53025 90537479
Abnormal behaviour 75.55 17.68 68 37875 22560 90567944
Electrocardiogram QT prolonged 74.09 17.68 119 37824 72337 90518167
Grandiosity 70.97 17.68 18 37925 291 90590213
Withdrawal syndrome 69.95 17.68 65 37878 22459 90568045
Muscle twitching 69.73 17.68 67 37876 24135 90566369
Dyskinesia 69.37 17.68 81 37862 36453 90554051
Gastrointestinal disorder 69.28 17.68 12 37931 256675 90333829
Euphoric mood 68.64 17.68 37 37906 5372 90585132
Confusional state 67.49 17.68 330 37613 385875 90204629
Postural tremor 67.41 17.68 19 37924 467 90590037
Infection 66.95 17.68 34 37909 362060 90228444
Delirium 66.84 17.68 140 37803 104219 90486285
Blister 66.50 17.68 13 37930 254985 90335519
Delusion 65.74 17.68 51 37892 13789 90576715
Aphasia 65.29 17.68 85 37858 42727 90547777
Irritable bowel syndrome 64.90 17.68 6 37937 207442 90383062
Depressed mood 64.89 17.68 92 37851 50130 90540374
Abdominal discomfort 64.36 17.68 63 37880 477265 90113239
Cognitive disorder 64.25 17.68 109 37834 69298 90521206
Poisoning 63.57 17.68 52 37891 15165 90575339
Neurotoxicity 62.93 17.68 60 37883 21407 90569097
Psychomotor hyperactivity 62.58 17.68 48 37895 12765 90577739
Adulterated product 61.97 17.68 17 37926 377 90590127
Toxic encephalopathy 61.92 17.68 41 37902 8658 90581846
Drug reaction with eosinophilia and systemic symptoms 60.75 17.68 82 37861 42676 90547828
Fatigue 60.23 17.68 264 37679 1153759 89436745
Antipsychotic drug level below therapeutic 60.17 17.68 16 37927 314 90590190
Polydipsia 59.51 17.68 31 37912 4200 90586304
Anticholinergic syndrome 59.41 17.68 27 37916 2716 90587788
Product tampering 59.25 17.68 17 37926 446 90590058
Treatment noncompliance 58.50 17.68 89 37854 51638 90538866
Abdominal pain upper 57.48 17.68 34 37909 332640 90257864
Amenorrhoea 57.44 17.68 44 37899 11678 90578826
Granulocytopenia 57.43 17.68 35 37908 6406 90584098
Myocarditis 57.30 17.68 47 37896 13759 90576745
Asthma 55.94 17.68 16 37927 242144 90348360
Hallucination, auditory 55.29 17.68 49 37894 15926 90574578
Action tremor 55.01 17.68 15 37928 325 90590179
Drug intolerance 54.84 17.68 64 37879 447527 90142977
Restlessness 54.59 17.68 71 37872 35649 90554855
Polyuria 54.34 17.68 40 37903 10000 90580504
Mental impairment 53.37 17.68 49 37894 16671 90573833
Osteoarthritis 53.14 17.68 9 37934 195721 90394783
Apathy 53.13 17.68 41 37902 10999 90579505
Sopor 52.49 17.68 58 37885 24586 90565918
Resting tremor 52.31 17.68 18 37925 865 90589639
Claustrophobia 52.23 17.68 20 37923 1307 90589197
Discomfort 51.84 17.68 25 37918 274310 90316194
Therapeutic product effect decreased 51.39 17.68 26 37917 277545 90312959
Lung disorder 50.68 17.68 3 37940 149880 90440624
Muscle injury 50.52 17.68 7 37936 176647 90413857
Cardio-respiratory arrest 50.48 17.68 93 37850 63047 90527457
Nephropathy 50.45 17.68 37 37906 9198 90581306
Impulsive behaviour 50.44 17.68 21 37922 1709 90588795
Disease recurrence 50.16 17.68 70 37873 37583 90552921
Blood cholesterol increased 49.43 17.68 13 37930 207999 90382505
Dystonia 49.28 17.68 47 37896 16772 90573732
Ill-defined disorder 49.10 17.68 9 37934 184882 90405622
Galactorrhoea 48.48 17.68 28 37915 4644 90585860
Chronic obstructive pulmonary disease 48.38 17.68 100 37843 73729 90516775
Schizoaffective disorder bipolar type 47.85 17.68 12 37931 185 90590319
Electrocardiogram T wave abnormal 47.53 17.68 23 37920 2665 90587839
Lower respiratory tract infection 47.12 17.68 23 37920 250636 90339868
Suspected suicide 47.07 17.68 36 37907 9532 90580972
Depressed level of consciousness 47.01 17.68 98 37845 72686 90517818
Brain injury 46.85 17.68 33 37910 7705 90582799
Pressure of speech 46.80 17.68 16 37927 754 90589750
Personality disorder 46.76 17.68 40 37903 12404 90578100
Blood creatine phosphokinase increased 46.44 17.68 64 37879 33959 90556545
Mobility decreased 45.65 17.68 24 37919 250710 90339794
General physical health deterioration 45.42 17.68 49 37894 355066 90235438
Inflammation 44.71 17.68 10 37933 178582 90411922
Acute kidney injury 44.44 17.68 257 37686 320130 90270374
Parathyroid tumour benign 43.75 17.68 16 37927 920 90589584
Blood prolactin increased 43.71 17.68 24 37919 3613 90586891
Mutism 43.39 17.68 19 37924 1750 90588754
Anger 43.39 17.68 40 37903 13680 90576824
Chronic kidney disease 42.76 17.68 76 37867 50115 90540389
Sleep-related eating disorder 42.65 17.68 16 37927 988 90589516
Arthritis 42.63 17.68 9 37934 167306 90423198
Cerebellar atrophy 42.24 17.68 15 37928 792 90589712
Injury 42.09 17.68 15 37928 197334 90393170
Weight increased 41.94 17.68 309 37634 417618 90172886
Brugada syndrome 41.54 17.68 13 37930 462 90590042
Anxiety 41.35 17.68 246 37697 309526 90280978
Mood swings 41.15 17.68 47 37896 20655 90569849
Neurological symptom 40.99 17.68 29 37914 6818 90583686
Tachyphrenia 40.80 17.68 18 37925 1688 90588816
Leukocytosis 40.36 17.68 57 37886 30933 90559571
Concussion 40.35 17.68 35 37908 11056 90579448
Urticaria 40.15 17.68 43 37900 312691 90277813
Musculoskeletal pain 40.13 17.68 11 37932 171240 90419264
Affective disorder 39.83 17.68 30 37913 7763 90582741
Product use issue 39.50 17.68 48 37895 329871 90260633
Febrile neutropenia 39.37 17.68 9 37934 158340 90432164
Major depression 39.23 17.68 33 37910 10002 90580502
Intentional product use issue 39.12 17.68 21 37922 216871 90373633
Hypothermia 39.09 17.68 40 37903 15535 90574969
Hypersensitivity myocarditis 38.85 17.68 11 37932 275 90590229
Disease progression 38.74 17.68 9 37934 156606 90433898
Drooling 38.74 17.68 24 37919 4522 90585982
Psychiatric decompensation 38.56 17.68 18 37925 1925 90588579
Pain in extremity 38.46 17.68 82 37861 450447 90140057
Self-injurious ideation 38.12 17.68 21 37922 3182 90587322
Nightmare 37.67 17.68 46 37897 21679 90568825
Speech disorder 37.52 17.68 68 37875 45517 90544987
Paroxysmal perceptual alteration 37.14 17.68 8 37935 60 90590444
Hereditary ataxia 37.05 17.68 7 37936 24 90590480
Enuresis 36.87 17.68 21 37922 3393 90587111
Bradykinesia 36.64 17.68 27 37916 6761 90583743
Anaemia 36.54 17.68 57 37886 352745 90237759
Pulse abnormal 36.13 17.68 20 37923 3059 90587445
Bursitis 35.84 17.68 6 37937 131648 90458856
Behaviour disorder 35.82 17.68 23 37920 4612 90585892
Bronchitis 35.50 17.68 10 37933 152917 90437587
Altered state of consciousness 35.29 17.68 54 37889 31478 90559026
Myoclonic epilepsy 35.19 17.68 16 37927 1611 90588893
Condition aggravated 34.97 17.68 392 37551 595153 89995351
Atrial fibrillation 34.42 17.68 7 37936 133604 90456900
Eye movement disorder 34.24 17.68 25 37918 6173 90584331
Mycobacterium ulcerans infection 34.14 17.68 7 37936 40 90590464
Gestational diabetes 33.75 17.68 31 37912 10551 90579953
Unmasking of previously unidentified disease 33.46 17.68 15 37928 1461 90589043
Urinary incontinence 33.44 17.68 58 37885 37508 90552996
Papillary thyroid cancer 33.42 17.68 18 37925 2609 90587895
Cough 33.31 17.68 65 37878 368897 90221607
Drug withdrawal syndrome 33.30 17.68 50 37893 28673 90561831
Self-destructive behaviour 32.99 17.68 11 37932 480 90590024
Vomiting 32.84 17.68 487 37456 787806 89802698
Drug hypersensitivity 32.81 17.68 93 37850 463516 90126988
Thyrotoxic crisis 32.75 17.68 14 37929 1217 90589287
Night sweats 32.65 17.68 7 37936 128759 90461745
Substance abuse 32.60 17.68 23 37920 5383 90585121
Middle insomnia 31.56 17.68 37 37906 16714 90573790
Cogwheel rigidity 31.29 17.68 16 37927 2086 90588418
Depression 31.13 17.68 224 37719 300377 90290127
Rhabdomyolysis 30.77 17.68 67 37876 51189 90539315
Acute psychosis 30.75 17.68 18 37925 3060 90587444
Autoimmune myocarditis 30.58 17.68 9 37934 259 90590245
Respiratory arrest 30.40 17.68 52 37891 33259 90557245
Back pain 30.28 17.68 54 37889 317121 90273383
Unresponsive to stimuli 30.28 17.68 56 37887 38065 90552439
Stupor 30.03 17.68 22 37921 5460 90585044
Intentional product misuse 29.90 17.68 94 37849 89510 90500994
Myocardial oedema 29.89 17.68 10 37933 441 90590063
Lethargy 29.68 17.68 75 37868 63064 90527440
Feeling guilty 29.67 17.68 11 37932 657 90589847
Lip dry 28.86 17.68 4 37939 100951 90489553
Asterixis 28.54 17.68 14 37929 1671 90588833
Electroencephalogram abnormal 28.42 17.68 19 37924 4077 90586427
Flat affect 28.34 17.68 14 37929 1697 90588807
Bradycardia 28.02 17.68 88 37855 83759 90506745
Musculoskeletal stiffness 27.85 17.68 51 37892 296481 90294023
Rebound psychosis 27.70 17.68 8 37935 215 90590289
Ideas of reference 27.61 17.68 7 37936 113 90590391
Pyrexia 27.54 17.68 163 37780 660322 89930182
Persecutory delusion 27.50 17.68 17 37926 3191 90587313
Psychotic symptom 27.42 17.68 15 37928 2241 90588263
Chest pain 27.41 17.68 58 37885 319587 90270917
Metabolic syndrome 27.07 17.68 14 37929 1868 90588636
Keratosis follicular 26.97 17.68 5 37938 15 90590489
Floppy infant 26.95 17.68 7 37936 125 90590379
Clonus 26.90 17.68 21 37922 5729 90584775
Vertigo 26.85 17.68 77 37866 69734 90520770
Cardiac hypertrophy 26.80 17.68 12 37931 1166 90589338
Hyperammonaemia 26.78 17.68 22 37921 6453 90584051
Gastrooesophageal reflux disease 26.77 17.68 139 37804 166198 90424306
Neuropathy peripheral 26.60 17.68 12 37931 136958 90453546
Hypophagia 26.32 17.68 51 37892 35886 90554618
Hyperhidrosis 26.31 17.68 120 37823 136185 90454319
Headache 26.27 17.68 233 37710 862513 89727991
Polyhydramnios 25.94 17.68 15 37928 2493 90588011
Goitre 25.93 17.68 22 37921 6745 90583759
Post-traumatic stress disorder 25.76 17.68 22 37921 6806 90583698
Grip strength decreased 25.69 17.68 4 37939 92572 90497932
Neuropsychiatric symptoms 25.58 17.68 10 37933 691 90589813
Limbic encephalitis 25.49 17.68 8 37935 287 90590217
Diarrhoea 25.48 17.68 261 37682 938929 89651575
Treatment failure 25.35 17.68 56 37887 303872 90286632
Foaming at mouth 25.23 17.68 12 37931 1338 90589166
End stage renal disease 25.20 17.68 24 37919 8547 90581957
CSWS syndrome 24.95 17.68 5 37938 25 90590479
Drug resistance 24.52 17.68 45 37898 30404 90560100
Product use in unapproved indication 24.29 17.68 231 37712 336005 90254499
Amniotic fluid volume increased 24.21 17.68 7 37936 189 90590315
Social avoidant behaviour 24.08 17.68 16 37927 3397 90587107
Depressive symptom 24.07 17.68 19 37924 5266 90585238
Hyperventilation 24.01 17.68 21 37922 6707 90583797
Thinking abnormal 23.93 17.68 27 37916 11705 90578799
Cardiac arrest 23.80 17.68 97 37846 104838 90485666
Muscle contractions involuntary 23.80 17.68 15 37928 2913 90587591
Hallucination, visual 23.69 17.68 38 37905 23054 90567450
Bundle branch block right 23.55 17.68 19 37924 5434 90585070
Death 23.34 17.68 105 37838 456446 90134058
Sleep apnoea syndrome 23.18 17.68 45 37898 31702 90558802
Hyperthermia 23.18 17.68 25 37918 10310 90580194
Poor quality sleep 23.13 17.68 39 37904 24654 90565850
Human herpesvirus 6 infection reactivation 22.98 17.68 9 37934 625 90589879
Electrocardiogram T wave inversion 22.98 17.68 16 37927 3667 90586837
Troponin increased 22.83 17.68 28 37915 13253 90577251
Malaise 22.66 17.68 148 37795 585838 90004666
Neutrophilia 22.58 17.68 19 37924 5759 90584745
Differential white blood cell count abnormal 22.37 17.68 10 37933 968 90589536
Dysgeusia 22.21 17.68 60 37883 52500 90538004
Seizure 22.16 17.68 124 37819 152505 90437999
Decreased appetite 22.12 17.68 82 37861 376458 90214046
COVID-19 21.90 17.68 23 37920 168820 90421684
Neutrophil count increased 21.41 17.68 33 37910 19357 90571147
Tooth injury 21.26 17.68 11 37932 1470 90589034
Compulsive sexual behaviour 21.17 17.68 5 37938 59 90590445
Psychiatric symptom 21.06 17.68 20 37923 7098 90583406
Platelet count decreased 20.94 17.68 16 37927 136953 90453551
Upper respiratory tract infection 20.92 17.68 14 37929 128304 90462200
Hallucination 20.92 17.68 68 37875 65891 90524613
Lower limb fracture 20.79 17.68 5 37938 85008 90505496
Maternal exposure during pregnancy 20.77 17.68 79 37864 359984 90230520
Gastrointestinal haemorrhage 20.76 17.68 6 37937 90242 90500262
Ammonia increased 20.74 17.68 17 37926 4969 90585535
Echolalia 20.55 17.68 7 37936 326 90590178
Hallucinations, mixed 20.25 17.68 18 37925 5871 90584633
Mood altered 20.09 17.68 30 37913 17114 90573390
Urinary retention 20.05 17.68 47 37896 37697 90552807
Parkinsonian gait 20.04 17.68 8 37935 584 90589920
Type 2 diabetes mellitus 19.94 17.68 34 37909 203210 90387294
Logorrhoea 19.77 17.68 13 37930 2714 90587790
Drug ineffective 19.76 17.68 736 37207 1383562 89206942
Lactate pyruvate ratio increased 19.76 17.68 5 37938 80 90590424
Hypersexuality 19.61 17.68 8 37935 618 90589886
Poisoning deliberate 19.54 17.68 29 37914 16457 90574047
Consciousness fluctuating 19.51 17.68 9 37934 937 90589567
Sciatica 19.50 17.68 9 37934 101373 90489131
Epileptic encephalopathy 19.49 17.68 7 37936 382 90590122
Ear infection 19.39 17.68 3 37940 69772 90520732
Hypercholesterolaemia 19.34 17.68 9 37934 100883 90489621
Feelings of worthlessness 19.33 17.68 7 37936 391 90590113
Renal oncocytoma 19.20 17.68 4 37939 25 90590479
Oedema 19.20 17.68 34 37909 200261 90390243
Prescribed underdose 19.18 17.68 4 37939 75015 90515489
Influenza 19.17 17.68 18 37925 139246 90451258
Unwanted awareness during anaesthesia 19.13 17.68 7 37936 403 90590101
Sinus tachycardia 19.12 17.68 39 37904 28474 90562030
Dialysis hypotension 19.10 17.68 6 37937 216 90590288
Agranulocytosis 19.04 17.68 44 37899 34958 90555546
Substance-induced psychotic disorder 18.99 17.68 13 37930 2899 90587605
Nystagmus 18.94 17.68 19 37924 7208 90583296
Potentiating drug interaction 18.87 17.68 17 37926 5645 90584859
Partial seizures 18.87 17.68 19 37924 7241 90583263
Eosinophilic pustular folliculitis 18.81 17.68 5 37938 98 90590406
Oxygen saturation decreased 18.52 17.68 11 37932 107472 90483032
Drug level above therapeutic 18.49 17.68 17 37926 5792 90584712
Body mass index increased 18.33 17.68 10 37933 1487 90589017
Nocturia 18.25 17.68 22 37921 10233 90580271
Dissociation 18.24 17.68 18 37925 6697 90583807
Hypertonia 18.21 17.68 16 37927 5139 90585365
Choluria 18.19 17.68 6 37937 253 90590251
Productive cough 17.95 17.68 5 37938 77058 90513446
Delusion of grandeur 17.94 17.68 6 37937 264 90590240
Status epilepticus 17.93 17.68 30 37913 18844 90571660
Blunted affect 17.79 17.68 6 37937 271 90590233

FDA Adverse Event Reporting System (Male)

MedDRA adverse event termLikelihood ratioLikelihood ratio thresholdPatients taking drug having adverse eventPatients taking drug not having adverse eventPatients not taking drug having adverse eventPatients not taking drug not having adverse event
Toxicity to various agents 757.52 18.26 834 26979 228302 42365220
Neuroleptic malignant syndrome 502.82 18.26 256 27557 21216 42572306
Nephrogenic diabetes insipidus 414.72 18.26 112 27701 1462 42592060
Mania 369.72 18.26 166 27647 10381 42583141
Tremor 318.70 18.26 353 27460 96576 42496946
Extrapyramidal disorder 300.12 18.26 166 27647 16246 42577276
Drug interaction 264.88 18.26 555 27258 266444 42327078
Psychotic disorder 259.59 18.26 187 27626 29021 42564501
Akathisia 251.47 18.26 127 27686 10324 42583198
Schizophrenia 230.10 18.26 120 27693 10430 42583092
Hallucination, auditory 227.83 18.26 134 27679 14730 42578792
Parkinsonism 215.15 18.26 115 27698 10508 42583014
Serotonin syndrome 203.80 18.26 154 27659 25691 42567831
Suicidal ideation 198.36 18.26 198 27615 47963 42545559
Obsessive-compulsive disorder 195.28 18.26 93 27720 6650 42586872
Suicide attempt 188.88 18.26 189 27624 45911 42547611
Antipsychotic drug level below therapeutic 174.43 18.26 69 27744 3135 42590387
Antipsychotic drug level increased 171.65 18.26 76 27737 4590 42588932
Completed suicide 168.16 18.26 257 27556 96208 42497314
Affective disorder 165.90 18.26 80 27733 5880 42587642
Delusion of grandeur 155.98 18.26 56 27757 1940 42591582
Schizoaffective disorder 134.37 18.26 50 27763 1920 42591602
Neutrophil count increased 132.26 18.26 107 27706 19697 42573825
Overdose 129.47 18.26 240 27573 105024 42488498
Sedation 128.57 18.26 127 27686 30348 42563174
Irritability 127.63 18.26 122 27691 28006 42565516
Euphoric mood 119.91 18.26 66 27747 6387 42587135
Rhinalgia 119.21 18.26 45 27768 1799 42591723
Leukopenia 110.74 18.26 185 27628 74561 42518961
Disinhibition 110.57 18.26 53 27760 3842 42589680
Lymphocyte count abnormal 108.31 18.26 44 27769 2143 42591379
Weight increased 104.79 18.26 223 27590 107760 42485762
Increased appetite 102.68 18.26 67 27746 8839 42584683
Hypomania 102.50 18.26 44 27769 2464 42591058
Hypernatraemia 102.49 18.26 70 27743 9962 42583560
Muscle rigidity 102.04 18.26 75 27738 11984 42581538
Treatment noncompliance 99.80 18.26 123 27690 37549 42555973
Aggression 99.41 18.26 133 27680 44030 42549492
Febrile neutropenia 97.39 18.26 6 27807 185697 42407825
Therapeutic product effect variable 96.53 18.26 45 27768 3064 42590458
Granulocytopenia 95.69 18.26 59 27754 7055 42586467
Myocarditis 93.30 18.26 86 27727 18852 42574670
Oppositional defiant disorder 88.98 18.26 27 27786 545 42592977
Salivary hypersecretion 87.98 18.26 66 27747 10877 42582645
Dyslipidaemia 87.51 18.26 62 27751 9356 42584166
Catatonia 87.13 18.26 53 27760 6186 42587336
Decreased eye contact 87.01 18.26 26 27787 497 42593025
Dyspnoea 86.66 18.26 97 27716 442524 42150998
Dyskinesia 85.84 18.26 94 27719 25296 42568226
Agitation 84.52 18.26 151 27662 64163 42529359
Rash 82.29 18.26 39 27774 276915 42316607
Bruxism 81.94 18.26 36 27777 2133 42591389
Antipsychotic drug level above therapeutic 81.79 18.26 31 27782 1253 42592269
Psychomotor hyperactivity 81.29 18.26 63 27750 10895 42582627
Abnormal behaviour 75.98 18.26 90 27723 26361 42567161
Priapism 70.94 18.26 47 27766 6360 42587162
Pruritus 70.76 18.26 18 27795 188753 42404769
Homicidal ideation 70.26 18.26 35 27778 2759 42590763
Obesity 70.15 18.26 69 27744 16390 42577132
Anaemia 69.68 18.26 49 27764 280229 42313293
Pain 68.92 18.26 37 27776 244811 42348711
Arthralgia 68.89 18.26 24 27789 205214 42388308
Diabetes insipidus 66.30 18.26 37 27776 3676 42589846
Coordination abnormal 63.48 18.26 48 27765 8002 42585520
Delusion 63.22 18.26 62 27751 14672 42578850
Prescribed overdose 62.30 18.26 58 27755 12869 42580653
Anxiety 61.04 18.26 193 27620 118367 42475155
Tardive dyskinesia 60.69 18.26 44 27769 6880 42586642
SARS-CoV-2 test positive 60.20 18.26 47 27766 8213 42585309
Death 59.44 18.26 138 27675 471047 42122475
Bipolar disorder 59.12 18.26 35 27778 3887 42589635
Paroxysmal perceptual alteration 58.86 18.26 16 27797 214 42593308
Hyperprolactinaemia 57.57 18.26 28 27785 2095 42591427
Oscillopsia 56.74 18.26 16 27797 247 42593275
Hyperreflexia 56.51 18.26 33 27780 3574 42589948
Leukocytosis 55.71 18.26 82 27731 29626 42563896
Dysarthria 55.55 18.26 96 27717 39711 42553811
Failure to suspend medication 54.18 18.26 17 27796 385 42593137
Myoclonus 53.92 18.26 61 27752 17004 42576518
Cognitive disorder 53.81 18.26 87 27726 34085 42559437
Pain in extremity 53.36 18.26 16 27797 150588 42442934
Dystonia 53.35 18.26 53 27760 12737 42580785
Cough 52.96 18.26 25 27788 178078 42415444
Drug ineffective 52.15 18.26 633 27180 629564 41963958
Confusional state 52.11 18.26 232 27581 167365 42426157
Affect lability 50.51 18.26 32 27781 4012 42589510
Malignant neoplasm progression 50.01 18.26 6 27807 108394 42485128
Intentional overdose 49.53 18.26 106 27707 51350 42542172
Antipsychotic drug level decreased 48.98 18.26 21 27792 1172 42592350
Neurotoxicity 48.32 18.26 68 27745 23583 42569939
Delirium 48.05 18.26 106 27707 52413 42541109
Dystonic tremor 47.47 18.26 15 27798 348 42593174
Choreoathetosis 47.11 18.26 20 27793 1089 42592433
Mental impairment 45.85 18.26 48 27765 12269 42581253
Erythema 45.60 18.26 8 27805 108785 42484737
Ataxia 44.87 18.26 54 27759 16071 42577451
Clonus 44.33 18.26 28 27785 3492 42590030
Pneumonia 43.13 18.26 137 27676 422012 42171510
Trismus 41.56 18.26 25 27788 2859 42590663
Hyperparathyroidism 40.94 18.26 19 27794 1280 42592242
Seizure 40.59 18.26 171 27642 120390 42473132
Restlessness 40.10 18.26 70 27743 29179 42564343
Depressed level of consciousness 39.64 18.26 93 27720 47877 42545645
Mental disorder 38.57 18.26 53 27760 17976 42575546
Sepsis 38.52 18.26 44 27769 199290 42394232
White blood cell count increased 37.90 18.26 88 27725 44999 42548523
Septic shock 37.85 18.26 7 27806 91665 42501857
Lymphocyte count decreased 37.40 18.26 66 27747 27743 42565779
Pancytopenia 37.40 18.26 15 27798 117728 42475794
Lethargy 36.68 18.26 89 27724 46801 42546721
Depression 35.97 18.26 156 27657 111207 42482315
Flight of ideas 35.84 18.26 12 27801 336 42593186
Neutropenia 35.42 18.26 237 27576 199194 42394328
Crying 35.36 18.26 31 27782 6363 42587159
Headache 34.36 18.26 65 27748 239304 42354218
Eosinophil count decreased 34.28 18.26 24 27789 3552 42589970
Conduction disorder 34.16 18.26 21 27792 2497 42591025
Mental status changes 34.09 18.26 81 27732 42034 42551488
Speech disorder 33.98 18.26 65 27748 29056 42564466
Decreased appetite 33.79 18.26 46 27767 193091 42400431
Back pain 33.60 18.26 26 27787 141750 42451772
Pleural effusion 33.19 18.26 11 27802 97155 42496367
Cardiac failure congestive 32.35 18.26 8 27805 85594 42507928
Suspected suicide 32.18 18.26 29 27784 6170 42587352
Blood creatine phosphokinase increased 31.85 18.26 86 27727 48252 42545270
Amblyopia 31.61 18.26 9 27804 144 42593378
Peripheral swelling 31.22 18.26 10 27803 90260 42503262
Paranoia 31.16 18.26 42 27771 13984 42579538
Thrombosis 31.08 18.26 4 27809 68507 42525015
Withdrawal syndrome 30.95 18.26 43 27770 14732 42578790
General physical health deterioration 30.74 18.26 32 27781 151214 42442308
Blood thyroid stimulating hormone decreased 30.56 18.26 19 27794 2304 42591218
Pyrexia 30.47 18.26 143 27670 393899 42199623
Atrial fibrillation 30.13 18.26 28 27785 139565 42453957
Pressure of speech 30.08 18.26 12 27801 557 42592965
Cerebellar atrophy 29.99 18.26 13 27800 745 42592777
Leukaemia 29.96 18.26 27 27786 5745 42587777
Infection 29.95 18.26 18 27795 112050 42481472
Long QT syndrome 29.76 18.26 21 27792 3146 42590376
Circulatory failure neonatal 29.71 18.26 6 27807 18 42593504
Polydipsia 29.42 18.26 24 27789 4464 42589058
Behaviour disorder 28.99 18.26 29 27784 7025 42586497
Psychiatric decompensation 28.57 18.26 23 27790 4199 42589323
Oedema peripheral 28.55 18.26 28 27785 136048 42457474
Foetal exposure during pregnancy 28.05 18.26 81 27732 47230 42546292
Enuresis 27.65 18.26 19 27794 2729 42590793
Neonatal tachypnoea 27.40 18.26 10 27803 363 42593159
Hyperkinesia 27.20 18.26 17 27796 2081 42591441
Schizoaffective disorder bipolar type 27.07 18.26 8 27805 147 42593375
Ascites 26.47 18.26 3 27810 56675 42536847
Sexual dysfunction 26.29 18.26 27 27786 6748 42586774
Chest discomfort 25.95 18.26 5 27808 63611 42529911
Brugada syndrome 25.91 18.26 13 27800 1040 42592482
Electrocardiogram QRS complex prolonged 25.91 18.26 25 27788 5798 42587724
Epistaxis 25.73 18.26 6 27807 66820 42526702
Accidental death 25.68 18.26 19 27794 3064 42590458
Autonomic nervous system imbalance 25.50 18.26 19 27794 3097 42590425
Neutrophilia 25.23 18.26 24 27789 5468 42588054
Incorrect dose administered 25.19 18.26 84 27729 52890 42540632
Hyperventilation 25.14 18.26 19 27794 3163 42590359
Defect conduction intraventricular 24.93 18.26 10 27803 471 42593051
Abdominal distension 24.71 18.26 8 27805 71727 42521795
Depressed mood 24.62 18.26 50 27763 23334 42570188
Electrocardiogram QT prolonged 24.58 18.26 78 27735 47867 42545655
Abdominal pain 24.54 18.26 55 27758 190416 42403106
Infusion related reaction 24.34 18.26 5 27808 60801 42532721
Haemorrhage 24.21 18.26 5 27808 60558 42532964
Insomnia 23.71 18.26 145 27668 118108 42475414
Drug withdrawal syndrome neonatal 23.41 18.26 21 27792 4440 42589082
Blunted affect 23.19 18.26 9 27804 388 42593134
Hyperammonaemic encephalopathy 22.98 18.26 17 27796 2741 42590781
Weight decreased 22.95 18.26 65 27748 207883 42385639
Speech sound disorder 22.81 18.26 7 27806 147 42593375
Photopsia 22.80 18.26 16 27797 2376 42591146
Generalised tonic-clonic seizure 22.72 18.26 52 27761 26327 42567195
Floppy infant 22.67 18.26 7 27806 150 42593372
Urticaria 22.59 18.26 10 27803 74026 42519496
Dyspnoea exertional 22.57 18.26 3 27810 50145 42543377
Oromandibular dystonia 22.54 18.26 10 27803 606 42592916
Coronary artery disease 22.39 18.26 4 27809 53716 42539806
Bipolar I disorder 22.32 18.26 11 27802 847 42592675
Tachycardia 22.23 18.26 127 27686 100960 42492562
Drug reaction with eosinophilia and systemic symptoms 22.07 18.26 69 27744 42006 42551516
Temperature regulation disorder 21.93 18.26 12 27801 1147 42592375
Disturbance in attention 21.57 18.26 55 27758 29811 42563711
Dry skin 21.50 18.26 3 27810 48335 42545187
Abulia 21.46 18.26 10 27803 680 42592842
Muscle spasms 21.38 18.26 15 27798 86029 42507493
Alopecia 21.24 18.26 54 27759 29222 42564300
Productive cough 21.15 18.26 4 27809 51563 42541959
Wrong patient received product 21.08 18.26 18 27795 3565 42589957
High-grade B-cell lymphoma 21.04 18.26 7 27806 192 42593330
Encephalopathy 20.96 18.26 67 27746 41266 42552256
Libido increased 20.96 18.26 11 27802 967 42592555
Secondary tic 20.95 18.26 4 27809 8 42593514
Convulsive threshold lowered 20.93 18.26 9 27804 506 42593016
Diabetic coma 20.72 18.26 11 27802 990 42592532
Mood altered 20.69 18.26 30 27783 10688 42582834
Job change 20.63 18.26 4 27809 9 42593513
Cardiac failure 20.17 18.26 24 27789 106832 42486690
Drooling 20.16 18.26 19 27794 4280 42589242
Rectal haemorrhage 20.02 18.26 4 27809 49602 42543920
Hyperammonaemia 19.72 18.26 25 27788 7841 42585681
Drug level increased 19.71 18.26 49 27764 26151 42567371
Agitation neonatal 19.60 18.26 12 27801 1416 42592106
Joint swelling 19.51 18.26 10 27803 68012 42525510
Mutism 19.34 18.26 12 27801 1450 42592072
Cerebrovascular accident 19.23 18.26 21 27792 97139 42496383
Poor quality sleep 19.07 18.26 27 27786 9413 42584109
Lung disorder 19.06 18.26 4 27809 47919 42545603
Toxic cardiomyopathy 19.00 18.26 8 27805 427 42593095
Muscle twitching 18.55 18.26 30 27783 11750 42581772
Disorientation 18.47 18.26 59 27754 36330 42557192
Psychotic symptom 18.29 18.26 14 27799 2376 42591146

FDA Adverse Event Reporting System (Geriatric)

MedDRA adverse event termLikelihood ratioLikelihood ratio thresholdPatients taking drug having adverse eventPatients taking drug not having adverse eventPatients not taking drug having adverse eventPatients not taking drug not having adverse event
Toxicity to various agents 1997.45 16.51 1789 55930 478766 110052814
Nephrogenic diabetes insipidus 1002.91 16.51 237 57482 2208 110529372
Neuroleptic malignant syndrome 994.47 16.51 441 57278 33618 110497962
Schizophrenia 874.91 16.51 354 57365 21472 110510108
Tremor 823.93 16.51 747 56972 201485 110330095
Drug interaction 716.20 16.51 1077 56642 499106 110032474
Mania 690.78 16.51 295 57424 20501 110511079
Psychotic disorder 671.76 16.51 385 57334 50552 110481028
Hypomania 664.40 16.51 236 57483 9974 110521606
Completed suicide 547.69 16.51 653 57066 241728 110289852
Extrapyramidal disorder 545.16 16.51 277 57442 28590 110502990
Suicidal ideation 477.14 16.51 394 57325 93543 110438037
Serotonin syndrome 409.12 16.51 298 57421 58855 110472725
Antipsychotic drug level increased 407.06 16.51 149 57570 6866 110524714
Akathisia 403.19 16.51 191 57528 16922 110514658
Suicide attempt 372.29 16.51 357 57362 103037 110428543
Obsessive-compulsive disorder 355.24 16.51 136 57583 7105 110524475
Catatonia 354.50 16.51 154 57565 11146 110520434
Sedation 328.38 16.51 280 57439 69403 110462177
Jaundice cholestatic 307.68 16.51 151 57568 14457 110517123
Ataxia 304.55 16.51 192 57527 29916 110501664
Parkinsonism 295.82 16.51 169 57550 22018 110509562
Hyperparathyroidism 289.94 16.51 99 57620 3711 110527869
Irritability 256.20 16.51 207 57512 47602 110483978
Cholelithiasis 249.29 16.51 230 57489 63192 110468388
Agitation 247.36 16.51 300 57419 112751 110418829
Hypernatraemia 238.18 16.51 136 57583 17697 110513883
Hallucination, auditory 234.11 16.51 155 57564 26242 110505338
Antipsychotic drug level below therapeutic 222.31 16.51 67 57652 1668 110529912
Overdose 220.70 16.51 419 57300 233375 110298205
Total lung capacity increased 215.41 16.51 86 57633 5026 110526554
Salivary hypersecretion 211.82 16.51 125 57594 17296 110514284
Muscle rigidity 200.84 16.51 136 57583 23895 110507685
Antipsychotic drug level above therapeutic 199.83 16.51 67 57652 2373 110529207
Asthma-chronic obstructive pulmonary disease overlap syndrome 197.48 16.51 86 57633 6258 110525322
Aggression 197.20 16.51 196 57523 59014 110472566
Bipolar disorder 195.35 16.51 95 57624 8912 110522668
Diabetes insipidus 194.59 16.51 86 57633 6484 110525096
Intentional overdose 193.87 16.51 289 57430 132212 110399368
Pain 192.20 16.51 132 57587 954823 109576757
Arthralgia 188.14 16.51 86 57633 779546 109752034
Schizoaffective disorder 187.10 16.51 68 57651 3068 110528512
Tardive dyskinesia 182.52 16.51 104 57615 13475 110518105
Euphoric mood 182.17 16.51 90 57629 8737 110522843
Delusion of grandeur 180.90 16.51 61 57658 2199 110529381
Affective disorder 172.69 16.51 94 57625 11147 110520433
Rash 161.76 16.51 116 57603 820848 109710732
Granulocytopenia 153.97 16.51 91 57628 12624 110518956
Dyspnoea 152.34 16.51 214 57505 1106658 109424922
Myoclonus 152.13 16.51 131 57588 32867 110498713
Hyperreflexia 150.39 16.51 81 57638 9404 110522176
Neutrophil count increased 148.57 16.51 132 57587 34520 110497060
Psychomotor hyperactivity 146.61 16.51 105 57614 20172 110511408
Infusion related reaction 145.46 16.51 15 57704 381147 110150433
Sarcoidosis 144.44 16.51 87 57632 12492 110519088
Pruritus 140.41 16.51 64 57655 581496 109950084
Dysarthria 139.84 16.51 195 57524 83926 110447654
Hepatotoxicity 139.83 16.51 169 57550 63231 110468349
Nasal polyps 138.04 16.51 86 57633 13114 110518466
Somnolence 135.30 16.51 401 57318 297048 110234532
Rheumatoid arthritis 134.36 16.51 5 57714 299608 110231972
Dyskinesia 133.31 16.51 149 57570 51297 110480283
Treatment noncompliance 130.08 16.51 175 57544 72815 110458765
Joint swelling 128.52 16.51 36 57683 442809 110088771
Myocarditis 125.90 16.51 113 57606 29942 110501638
Libido increased 125.65 16.51 48 57671 2491 110529089
Stomatitis 122.96 16.51 4 57715 270238 110261342
Swelling 119.15 16.51 20 57699 351021 110180559
Arthropathy 118.79 16.51 8 57711 287514 110244066
Delirium 118.73 16.51 235 57484 134790 110396790
Abnormal behaviour 118.60 16.51 123 57596 38916 110492664
Nasopharyngitis 118.32 16.51 30 57689 394331 110137249
Hyperprolactinaemia 118.01 16.51 61 57658 6514 110525066
Disorientation 116.23 16.51 163 57556 70508 110461072
Disinhibition 115.85 16.51 48 57671 3086 110528494
Pleurothotonus 115.68 16.51 45 57674 2453 110529127
Confusional state 115.16 16.51 517 57202 468163 110063417
Peripheral swelling 115.10 16.51 34 57685 404000 110127580
Blood bilirubin increased 114.36 16.51 168 57551 75804 110455776
Rhinitis allergic 114.20 16.51 86 57633 17836 110513744
Dystonia 112.02 16.51 99 57620 25706 110505874
Mental status changes 111.23 16.51 166 57553 75956 110455624
Lymphocyte count abnormal 109.87 16.51 43 57676 2383 110529197
Febrile neutropenia 109.85 16.51 17 57702 316750 110214830
Hypersensitivity 109.73 16.51 37 57682 403961 110127619
Paranoia 109.63 16.51 92 57627 22282 110509298
Neurotoxicity 108.94 16.51 122 57597 42085 110489495
Delusion 106.85 16.51 93 57626 23662 110507918
Withdrawal syndrome 106.54 16.51 105 57614 31275 110500305
Sinusitis 105.00 16.51 15 57704 296673 110234907
Cognitive disorder 100.55 16.51 171 57548 87340 110444240
Drug level increased 98.43 16.51 123 57596 47596 110483984
Wound 98.38 16.51 6 57713 234431 110297149
Paroxysmal perceptual alteration 97.74 16.51 24 57695 266 110531314
Oppositional defiant disorder 97.58 16.51 27 57692 491 110531089
Leukocytosis 97.34 16.51 130 57589 53698 110477882
Mental disorder 96.49 16.51 110 57609 38681 110492899
Anaemia 94.30 16.51 88 57631 546998 109984582
Cardiac murmur 94.19 16.51 88 57631 24540 110507040
Rhinalgia 92.97 16.51 44 57675 3885 110527695
Hostility 91.98 16.51 39 57680 2657 110528923
Therapeutic product effect variable 91.67 16.51 39 57680 2679 110528901
Leukopenia 91.14 16.51 224 57495 148567 110383013
Bruxism 88.67 16.51 46 57673 4948 110526632
Intentional self-injury 87.84 16.51 103 57616 37326 110494254
Depressed level of consciousness 87.57 16.51 186 57533 112092 110419488
Encephalopathy 87.39 16.51 154 57565 80901 110450679
Psoriatic arthropathy 85.80 16.51 4 57715 196757 110334823
Impaired healing 85.77 16.51 4 57715 196713 110334867
Anxiety 85.68 16.51 382 57337 344696 110186884
Bipolar I disorder 84.51 16.51 35 57684 2248 110529332
Priapism 84.48 16.51 47 57672 5814 110525766
Infection 84.05 16.51 42 57677 362158 110169422
General physical health deterioration 83.71 16.51 60 57659 425235 110106345
Somatic symptom disorder 82.89 16.51 38 57681 3121 110528459
Increased appetite 82.65 16.51 66 57653 14911 110516669
Cough 81.02 16.51 73 57646 461568 110070012
Homicidal ideation 80.90 16.51 39 57680 3588 110527992
Weight increased 80.17 16.51 431 57288 419213 110112367
Drug reaction with eosinophilia and systemic symptoms 79.65 16.51 149 57570 81946 110449634
Asthma 79.08 16.51 17 57702 250274 110281306
Decreased eye contact 78.41 16.51 26 57693 889 110530691
Soft tissue injury 77.90 16.51 33 57686 2243 110529337
Disturbance in attention 77.73 16.51 126 57593 61869 110469711
Electrocardiogram QT prolonged 77.57 16.51 174 57545 108786 110422794
Pain in extremity 77.46 16.51 84 57635 487034 110044546
Blood creatine phosphokinase increased 76.41 16.51 137 57582 72940 110458640
Restlessness 75.56 16.51 118 57601 56141 110475439
Toxic encephalopathy 75.45 16.51 63 57656 15151 110516429
Drug ineffective 74.73 16.51 1159 56560 1519381 109012199
Urticaria 73.93 16.51 37 57682 318820 110212760
Cerebellar atrophy 73.81 16.51 28 57691 1425 110530155
Suspected suicide 73.44 16.51 62 57657 15137 110516443
Oculogyric crisis 72.97 16.51 37 57682 3795 110527785
Blister 72.74 16.51 15 57704 227361 110304219
Polydipsia 72.68 16.51 47 57672 7641 110523939
Clonus 72.03 16.51 49 57670 8667 110522913
Camptocormia 71.92 16.51 21 57698 467 110531113
Abdominal pain upper 71.68 16.51 47 57672 349064 110182516
Lung disorder 71.53 16.51 6 57713 180041 110351539
Hypercalcaemia 71.39 16.51 104 57615 46553 110485027
Arthritis 71.19 16.51 4 57715 167582 110363998
Post-traumatic neck syndrome 70.56 16.51 32 57687 2563 110529017
Osteoarthritis 70.10 16.51 7 57712 182616 110348964
Oscillopsia 69.94 16.51 20 57699 412 110531168
Pressure of speech 68.86 16.51 26 57693 1306 110530274
Malignant neoplasm progression 68.85 16.51 6 57713 174561 110357019
Hypothyroidism 67.85 16.51 130 57589 72769 110458811
Speech disorder 67.69 16.51 118 57601 61451 110470129
Schizoaffective disorder bipolar type 66.92 16.51 18 57701 293 110531287
Sternal fracture 66.02 16.51 33 57686 3283 110528297
Musculoskeletal pain 65.33 16.51 9 57710 183014 110348566
Depressed mood 64.85 16.51 115 57604 60694 110470886
Brugada syndrome 64.43 16.51 26 57693 1562 110530018
Grandiosity 64.15 16.51 20 57699 559 110531021
Choreoathetosis 62.74 16.51 26 57693 1672 110529908
Bronchiectasis 62.73 16.51 86 57633 36407 110495173
Headache 62.59 16.51 243 57476 882134 109649446
Contraindicated product administered 61.91 16.51 26 57693 248241 110283339
Irritable bowel syndrome 61.23 16.51 7 57712 164208 110367372
Seizure 61.12 16.51 253 57466 220932 110310648
Behaviour disorder 60.81 16.51 46 57673 9601 110521979
Back pain 60.04 16.51 63 57656 370933 110160647
Action tremor 59.49 16.51 18 57701 454 110531126
Enuresis 59.46 16.51 33 57686 4063 110527517
Therapeutic product effect decreased 58.69 16.51 27 57692 244289 110287291
Apathy 58.23 16.51 56 57663 16183 110515397
Drug hypersensitivity 58.13 16.51 92 57627 453998 110077582
Gastrointestinal disorder 57.71 16.51 27 57692 241925 110289655
Inflammation 57.34 16.51 15 57704 193223 110338357
Lung neoplasm malignant 57.04 16.51 79 57640 33763 110497817
Muscle twitching 56.74 16.51 74 57645 29861 110501719
Lethargy 56.35 16.51 140 57579 93436 110438144
Fatigue 55.27 16.51 390 57329 1215568 109316012
Lower respiratory tract infection 55.16 16.51 29 57690 243077 110288503
Product tampering 54.98 16.51 17 57702 462 110531118
Pericarditis 54.54 16.51 23 57696 219091 110312489
Drug intolerance 54.29 16.51 80 57639 406432 110125148
Mutism 53.34 16.51 28 57691 3085 110528495
Malaise 52.90 16.51 177 57542 671642 109859938
Intentional product use issue 52.76 16.51 32 57687 247874 110283706
Mental impairment 52.62 16.51 62 57657 22577 110509003
Affect lability 51.77 16.51 56 57663 18581 110512999
Drooling 51.67 16.51 37 57682 7102 110524478
Ill-defined disorder 50.89 16.51 10 57709 156843 110374737
Failure to suspend medication 50.57 16.51 16 57703 470 110531110
Altered state of consciousness 50.26 16.51 100 57619 57526 110474054
Dystonic tremor 50.21 16.51 15 57704 362 110531218
Bradykinesia 50.06 16.51 43 57676 10745 110520835
Mobility decreased 50.04 16.51 31 57688 237391 110294189
Bursitis 49.81 16.51 5 57714 129913 110401667
Abdominal discomfort 49.26 16.51 81 57638 393777 110137803
Night sweats 49.23 16.51 6 57713 133977 110397603
Postural tremor 49.06 16.51 19 57700 1023 110530557
Acute kidney injury 49.05 16.51 527 57192 634903 109896677
Hyperventilation 48.46 16.51 39 57680 8908 110522672
Atrial fibrillation 48.37 16.51 30 57689 229612 110301968
Muscle injury 47.79 16.51 8 57711 140799 110390781
Erythema 47.70 16.51 49 57670 291398 110240182
Anticholinergic syndrome 47.58 16.51 29 57690 4251 110527329
Aphasia 47.45 16.51 99 57620 58898 110472682
Depression 47.02 16.51 305 57414 317030 110214550
Antipsychotic drug level decreased 46.76 16.51 20 57699 1392 110530188
Discomfort 46.70 16.51 27 57692 214680 110316900
Dyslipidaemia 46.16 16.51 49 57670 15916 110515664
Pyrexia 45.86 16.51 278 57441 897987 109633593
Nephropathy 45.59 16.51 45 57674 13422 110518158
Polyuria 45.30 16.51 51 57668 17687 110513893
Bronchitis 45.06 16.51 13 57706 157019 110374561
Trismus 45.04 16.51 33 57686 6563 110525017
Claustrophobia 44.61 16.51 20 57699 1559 110530021
Decreased appetite 44.20 16.51 116 57603 475730 110055850
Unmasking of previously unidentified disease 44.09 16.51 24 57695 2844 110528736
Blood cholesterol increased 43.48 16.51 21 57698 184764 110346816
Amenorrhoea 43.26 16.51 37 57682 9194 110522386
Resting tremor 42.94 16.51 20 57699 1703 110529877
Electrocardiogram T wave abnormal 42.89 16.51 27 57692 4190 110527390
Poor quality sleep 42.10 16.51 62 57657 28015 110503565
Psychiatric decompensation 42.00 16.51 30 57689 5735 110525845
Abdominal pain 41.84 16.51 133 57586 512856 110018724
Parathyroid tumour benign 41.71 16.51 17 57702 1048 110530532
White blood cell count increased 41.53 16.51 128 57591 96714 110434866
Death 41.28 16.51 206 57513 698663 109832917
Hyperammonaemia 41.22 16.51 43 57676 13689 110517891
Alopecia 41.12 16.51 80 57639 364673 110166907
Adulterated product 40.37 16.51 17 57702 1138 110530442
Septic shock 40.07 16.51 16 57703 157512 110374068
Oxygen saturation decreased 39.84 16.51 16 57703 156966 110374614
Feelings of worthlessness 39.75 16.51 14 57705 576 110531004
Neutrophilia 39.67 16.51 37 57682 10292 110521288
Autonomic nervous system imbalance 39.65 16.51 29 57690 5751 110525829
Sepsis 39.38 16.51 69 57650 327277 110204303
Drug withdrawal syndrome 39.33 16.51 71 57648 37983 110493597
Poisoning 39.01 16.51 61 57658 29044 110502536
Injury 38.96 16.51 22 57697 177243 110354337
Wound infection 38.91 16.51 3 57716 96462 110435118
Sopor 38.81 16.51 69 57650 36477 110495103
Major depression 38.79 16.51 37 57682 10584 110520996
SARS-CoV-2 test positive 38.73 16.51 46 57673 16889 110514691
Chest pain 38.69 16.51 87 57632 376288 110155292
Cogwheel rigidity 38.43 16.51 24 57695 3674 110527906
Impulsive behaviour 38.24 16.51 23 57696 3292 110528288
Myelosuppression 37.86 16.51 3 57716 94337 110437243
Drug abuse 37.82 16.51 188 57531 177223 110354357
Pleural effusion 37.72 16.51 23 57696 177686 110353894
Cardiac hypertrophy 37.66 16.51 19 57700 1928 110529652
Ascites 37.11 16.51 3 57716 92805 110438775
Speech sound disorder 37.07 16.51 8 57711 47 110531533
Echolalia 36.84 16.51 13 57706 538 110531042
Hyperammonaemic encephalopathy 36.68 16.51 27 57692 5407 110526173
Personality disorder 36.41 16.51 39 57680 12798 110518782
Electrocardiogram QRS complex prolonged 35.95 16.51 39 57680 12982 110518598
Blood prolactin increased 35.78 16.51 25 57694 4617 110526963
Productive cough 35.61 16.51 8 57711 114297 110417283
Flight of ideas 35.32 16.51 14 57705 802 110530778
Hyperhidrosis 34.76 16.51 191 57528 187107 110344473
Chronic kidney disease 34.75 16.51 103 57616 76188 110455392
Paraesthesia 34.44 16.51 57 57662 276464 110255116
Concussion 34.40 16.51 36 57683 11502 110520078
Long QT syndrome 34.31 16.51 29 57690 7089 110524491
Tachycardia 34.27 16.51 219 57500 226426 110305154
Eosinophil count decreased 34.23 16.51 27 57692 5991 110525589
Hypersensitivity myocarditis 34.17 16.51 11 57708 342 110531238
Agranulocytosis 33.65 16.51 89 57630 61671 110469909
Sleep-related eating disorder 33.63 16.51 14 57705 911 110530669
Galactorrhoea 33.49 16.51 23 57696 4132 110527448
Feeling guilty 33.32 16.51 14 57705 932 110530648
Blunted affect 33.17 16.51 12 57707 534 110531046
Intentional product misuse 32.82 16.51 147 57572 132757 110398823
Drug level above therapeutic 32.50 16.51 35 57684 11553 110520027
Upper respiratory tract infection 32.33 16.51 14 57705 131314 110400266
Muscle contractions involuntary 32.09 16.51 23 57696 4421 110527159
Logorrhoea 32.05 16.51 24 57695 4933 110526647
Body mass index increased 31.72 16.51 18 57701 2312 110529268
Conduction disorder 31.63 16.51 22 57697 4033 110527547
Anger 31.47 16.51 44 57675 18963 110512617
Coordination abnormal 31.24 16.51 51 57668 25177 110506403
Rhabdomyolysis 31.12 16.51 135 57584 120266 110411314
Dyspnoea exertional 31.01 16.51 8 57711 104052 110427528
Mood swings 30.84 16.51 48 57671 22764 110508816
Cardio-respiratory arrest 30.80 16.51 131 57588 115705 110415875
Dry skin 30.72 16.51 9 57710 107644 110423936
Papillary thyroid cancer 30.62 16.51 19 57700 2875 110528705
Disease recurrence 30.52 16.51 85 57634 60699 110470881
Neutropenia 30.39 16.51 314 57405 374306 110157274
Hereditary ataxia 30.34 16.51 6 57713 21 110531559
Mood altered 30.33 16.51 46 57673 21329 110510251
Hallucination, visual 30.16 16.51 65 57654 39540 110492040
Anaphylactic reaction 30.08 16.51 11 57708 114289 110417291
Gambling disorder 30.03 16.51 17 57702 2174 110529406
Unresponsive to stimuli 29.89 16.51 87 57632 63703 110467877
Wrong patient received product 29.75 16.51 26 57693 6648 110524932
Psychiatric symptom 29.74 16.51 30 57689 9183 110522397
Thrombosis 29.38 16.51 10 57709 108652 110422928
Pneumonitis 29.19 16.51 3 57716 76528 110455052
Bundle branch block right 29.12 16.51 34 57685 12257 110519323
Hyperthermia 29.09 16.51 45 57674 21227 110510353
Persecutory delusion 29.04 16.51 25 57694 6266 110525314
Abulia 28.93 16.51 14 57705 1299 110530281
Neurological symptom 28.68 16.51 38 57681 15570 110516010
Metabolic syndrome 28.62 16.51 19 57700 3228 110528352
Renal cyst 28.51 16.51 41 57678 18131 110513449
Urinary incontinence 28.51 16.51 72 57647 48515 110483065
Rebound psychosis 28.47 16.51 10 57709 408 110531172
Grip strength decreased 28.47 16.51 4 57715 80170 110451410
Social avoidant behaviour 28.22 16.51 23 57696 5346 110526234
Pancytopenia 28.20 16.51 41 57678 209572 110322008
Liver disorder 28.03 16.51 20 57699 142223 110389357
Gastrointestinal haemorrhage 28.02 16.51 27 57692 165491 110366089
Blood thyroid stimulating hormone decreased 27.93 16.51 26 57693 7213 110524367
Hypophagia 27.83 16.51 75 57644 52551 110479029
Vision blurred 27.68 16.51 137 57582 128885 110402695
Rectal haemorrhage 27.61 16.51 14 57705 119819 110411761
Acute psychosis 27.56 16.51 22 57697 4965 110526615
Middle insomnia 27.52 16.51 43 57676 20459 110511121
Oedema 27.35 16.51 42 57677 209934 110321646
Sinus tachycardia 27.23 16.51 67 57652 44426 110487154
Hallucination 27.19 16.51 115 57604 101317 110430263
Colitis ulcerative 27.14 16.51 4 57715 77359 110454221
Eosinophilia 27.13 16.51 79 57640 57857 110473723
Gait inability 27.11 16.51 19 57700 136357 110395223
Leukaemia 27.10 16.51 26 57693 7492 110524088
Hypercholesterolaemia 27.03 16.51 7 57712 90830 110440750
Generalised tonic-clonic seizure 27.00 16.51 76 57643 54604 110476976
Cerebrovascular accident 26.89 16.51 33 57686 181251 110350329
Colitis 26.67 16.51 10 57709 102313 110429267
Injection site erythema 26.64 16.51 8 57711 94168 110437412
Pulse abnormal 26.63 16.51 20 57699 4129 110527451
Brain injury 26.61 16.51 34 57685 13442 110518138
Sinus node dysfunction 26.57 16.51 28 57691 9019 110522561
Hyperkinesia 26.55 16.51 18 57701 3166 110528414
Muscle spasms 26.42 16.51 67 57652 278090 110253490
Psychomotor retardation 26.31 16.51 26 57693 7766 110523814
Thrombocytopenia 26.00 16.51 94 57625 348791 110182789
Sleep apnoea syndrome 25.92 16.51 62 57657 40385 110491195
Sciatica 25.87 16.51 8 57711 92391 110439189
Bradycardia 25.84 16.51 154 57565 155363 110376217
Diarrhoea 25.84 16.51 429 57290 1139076 109392504
Hypothermia 25.82 16.51 48 57671 26254 110505326
Self-injurious ideation 25.81 16.51 20 57699 4326 110527254
Mycobacterium ulcerans infection 25.42 16.51 7 57712 125 110531455
Goitre 25.33 16.51 23 57696 6181 110525399
Cardiac failure congestive 25.13 16.51 25 57694 150975 110380605
Stupor 25.02 16.51 26 57693 8239 110523341
Epistaxis 24.83 16.51 19 57700 130353 110401227
Self-destructive behaviour 24.70 16.51 11 57708 844 110530736
Depressive symptom 24.64 16.51 26 57693 8388 110523192
Coronary artery disease 24.48 16.51 4 57715 71686 110459894
Herpes zoster 24.47 16.51 13 57706 108366 110423214
Sexual dysfunction 24.34 16.51 26 57693 8504 110523076
Myoclonic epilepsy 24.33 16.51 16 57703 2675 110528905
Crying 24.20 16.51 46 57673 25582 110505998
Torticollis 24.02 16.51 17 57702 3204 110528376
Autoimmune disorder 23.89 16.51 3 57716 65480 110466100
Oromandibular dystonia 23.88 16.51 12 57707 1207 110530373
Haemorrhage 23.79 16.51 13 57706 106679 110424901
Staphylococcal infection 23.67 16.51 4 57715 69940 110461640
Rhinorrhoea 23.64 16.51 12 57707 102654 110428926
Psychotic symptom 23.41 16.51 18 57701 3849 110527731
Defect conduction intraventricular 23.18 16.51 10 57709 711 110530869
Keratosis follicular 23.08 16.51 5 57714 30 110531550
Disease progression 23.01 16.51 59 57660 243975 110287605
Dissociation 22.95 16.51 27 57692 9815 110521765
Flat affect 22.91 16.51 15 57704 2490 110529090
Hypertonia 22.90 16.51 25 57694 8381 110523199
Judgement impaired 22.90 16.51 12 57707 1318 110530262
Ideas of reference 22.68 16.51 7 57712 189 110531391
Convulsive threshold lowered 22.58 16.51 11 57708 1035 110530545
Ear infection 22.58 16.51 3 57716 62729 110468851
Diabetic coma 22.58 16.51 12 57707 1356 110530224
Chest discomfort 22.42 16.51 35 57684 173813 110357767
Coma 22.40 16.51 121 57598 117748 110413832
Gross motor delay 22.37 16.51 7 57712 198 110531382
Post-traumatic stress disorder 22.25 16.51 22 57697 6574 110525006
Weight decreased 22.20 16.51 148 57571 467909 110063671
Lymphocyte count decreased 22.11 16.51 73 57646 57170 110474410
Limbic encephalitis 22.08 16.51 10 57709 798 110530782
Asterixis 22.02 16.51 16 57703 3142 110528438
CSWS syndrome 21.83 16.51 5 57714 40 110531540
Oropharyngeal pain 21.83 16.51 23 57696 135253 110396327
Restless legs syndrome 21.79 16.51 43 57676 24583 110506997
Essential tremor 21.72 16.51 13 57706 1845 110529735
Job change 21.52 16.51 4 57715 9 110531571
Hypomagnesaemia 21.46 16.51 3 57716 60367 110471213
Hypokalaemia 21.44 16.51 39 57680 182409 110349171
Product use in unapproved indication 21.36 16.51 340 57379 447037 110084543
Muscle contracture 21.35 16.51 15 57704 2793 110528787
Road traffic accident 21.29 16.51 15 57704 107383 110424197
Tachyphrenia 21.28 16.51 14 57705 2342 110529238
Product use issue 21.28 16.51 87 57632 311608 110219972
Cardiac failure 21.26 16.51 41 57678 187585 110343995
Polyhydramnios 21.24 16.51 13 57706 1920 110529660
Electrocardiogram T wave inversion 21.15 16.51 20 57699 5660 110525920
Renal oncocytoma 21.06 16.51 7 57712 241 110531339
Melaena 21.04 16.51 5 57714 68752 110462828
Nystagmus 20.98 16.51 28 57691 11549 110520031
Secondary tic 20.95 16.51 4 57715 11 110531569
Influenza 20.91 16.51 35 57684 169066 110362514
High-grade B-cell lymphoma 20.87 16.51 7 57712 248 110531332
Potentiating drug interaction 20.86 16.51 28 57691 11615 110519965
Autoimmune myocarditis 20.83 16.51 9 57710 642 110530938
Eczema 20.71 16.51 6 57713 72287 110459293
Thinking abnormal 20.66 16.51 32 57687 15108 110516472
Thyrotoxic crisis 20.60 16.51 13 57706 2027 110529553
Sexually inappropriate behaviour 20.57 16.51 9 57710 662 110530918
Haematoma 20.57 16.51 3 57716 58473 110473107
Skin exfoliation 20.55 16.51 10 57709 87641 110443939
Balance disorder 20.38 16.51 117 57602 116443 110415137
Blood pressure systolic increased 20.18 16.51 9 57710 82982 110448598
Maternal exposure during pregnancy 20.11 16.51 67 57652 254816 110276764
Paralysis 19.95 16.51 32 57687 15568 110516012
Type 2 diabetes mellitus 19.84 16.51 39 57680 177193 110354387
Cystitis 19.82 16.51 5 57714 66031 110465549
Consciousness fluctuating 19.72 16.51 13 57706 2183 110529397
Condition aggravated 19.60 16.51 512 57207 734324 109797256
Body temperature increased 19.57 16.51 68 57651 54645 110476935
Taste disorder 19.53 16.51 5 57714 65382 110466198
Prescribed underdose 19.44 16.51 5 57714 65169 110466411
Cerebellar syndrome 19.39 16.51 20 57699 6282 110525298
Haematochezia 19.37 16.51 19 57700 115505 110416075
Clear cell renal cell carcinoma 19.30 16.51 14 57705 2742 110528838
Myocardial infarction 19.23 16.51 45 57674 192038 110339542
Haemoglobin decreased 19.21 16.51 66 57653 248661 110282919
Lactate pyruvate ratio increased 19.10 16.51 5 57714 73 110531507
Polydipsia psychogenic 18.86 16.51 7 57712 335 110531245
Respiratory arrest 18.76 16.51 70 57649 58229 110473351
Hypersexuality 18.68 16.51 12 57707 1928 110529652
Haemoptysis 18.55 16.51 7 57712 71347 110460233
Dialysis hypotension 18.41 16.51 6 57713 194 110531386
Drug level decreased 18.40 16.51 34 57685 18514 110513066
Blood pressure fluctuation 18.38 16.51 8 57711 74816 110456764
Movement disorder 18.37 16.51 51 57668 36353 110495227
Eye movement disorder 18.36 16.51 24 57695 9704 110521876
Dry mouth 18.34 16.51 49 57670 199899 110331681
Angina pectoris 18.16 16.51 5 57714 62290 110469290
Distractibility 18.04 16.51 9 57710 892 110530688
Rabbit syndrome 17.99 16.51 7 57712 382 110531198
Musculoskeletal stiffness 17.93 16.51 80 57639 279742 110251838
Electroconvulsive therapy 17.72 16.51 5 57714 98 110531482
Unwanted awareness during anaesthesia 17.65 16.51 7 57712 402 110531178
Fluid retention 17.63 16.51 14 57705 94293 110437287
Nervous system disorder 17.57 16.51 46 57673 31675 110499905
Poisoning deliberate 17.57 16.51 41 57678 26290 110505290
Visuospatial deficit 17.46 16.51 4 57715 32 110531548
Accidental death 17.44 16.51 17 57702 4992 110526588
Swollen tongue 17.31 16.51 5 57714 60357 110471223
Hallucinations, mixed 17.27 16.51 22 57697 8671 110522909
Injection site pruritus 17.19 16.51 3 57716 51255 110480325
Stereotypy 17.01 16.51 9 57710 1008 110530572
Fungal infection 16.98 16.51 3 57716 50803 110480777
Foaming at mouth 16.97 16.51 12 57707 2258 110529322
Hepatocellular injury 16.91 16.51 3 57716 50639 110480941
Syncope 16.84 16.51 52 57667 202484 110329096
Gestational diabetes 16.78 16.51 20 57699 7369 110524211
Injection site pain 16.78 16.51 43 57676 177879 110353701

FDA Adverse Event Reporting System (Pediatric)

MedDRA adverse event termLikelihood ratioLikelihood ratio thresholdPatients taking drug having adverse eventPatients taking drug not having adverse eventPatients not taking drug having adverse eventPatients not taking drug not having adverse event
Floppy infant 40.66 32.96 14 202 143 113594
Amblyopia 35.19 32.96 9 207 27 113710
Facial paralysis 35.19 32.96 9 207 27 113710

Pharmacologic Action:

SourceCodeDescription
ATC N05AN01 NERVOUS SYSTEM
PSYCHOLEPTICS
ANTIPSYCHOTICS
Lithium
MeSH PA D000928 Antidepressive Agents
MeSH PA D002492 Central Nervous System Depressants
MeSH PA D004791 Enzyme Inhibitors
MeSH PA D011619 Psychotropic Drugs
MeSH PA D018692 Antimanic Agents
CHEBI has role CHEBI:35469 antidepressants

Related Drugs by ATC class:

N05AN Lithium 1 drug
lithium carbonate

Drug Use | Suggest Off label Use Form| |View source of the data|

DiseaseRelationSNOMED_IDDOID
Bipolar disorder indication 13746004 DOID:3312
Bipolar disorder in remission indication 85248005
Bipolar affective disorder, current episode manic indication 191618007
Vascular headache off-label use 128187005
Bipolar affective disorder, current episode depression off-label use 191627008 DOID:3312
Cluster Headache Prevention off-label use
Rapid Cycling Bipolar Affective Disorder off-label use
Psoriasis contraindication 9014002 DOID:8893
Diabetes insipidus contraindication 15771004 DOID:9409
Polyuria contraindication 28442001
Hypothyroidism contraindication 40930008 DOID:1459
Conduction disorder of the heart contraindication 44808001
Chronic heart failure contraindication 48447003
Acute infectious disease contraindication 63171007
Hyponatremia contraindication 89627008
Kidney disease contraindication 90708001 DOID:557
Organic mental disorder contraindication 111479008
Plaque psoriasis contraindication 200965009
Pregnancy, function contraindication 289908002
Breastfeeding (mother) contraindication 413712001
Severe dehydration contraindication 450316000
Lithium Toxicity contraindication




🐶 Veterinary Drug Use

None

🐶 Veterinary products

None

Acid dissociation constants calculated using MoKa v3.0.0

None

Orange Book patent data (new drug applications)

None

Orange Book exclusivity data (new drug applications)

None

Bioactivity Summary:

TargetClassPharosUniProtActionTypeActivity value
(-log[M])		Mechanism
action		Bioact sourceMoA source
Glycogen synthase kinase-3 Kinase INHIBITOR CHEMBL CHEMBL
Inositol-1(or 4)-monophosphatase 1 Enzyme INHIBITOR CHEMBL CHEMBL

External reference:

IDSource
D04749 KEGG_DRUG
4018009 VUID
N0000179333 NUI
6080-58-6 SECONDARY_CAS_RN
4018008 VANDF
4018009 VANDF
4019803 VANDF
CHEBI:64735 CHEBI
CHEMBL2103738 ChEMBL_ID
CHEMBL1200826 ChEMBL_ID
C070669 MESH_SUPPLEMENTAL_RECORD_UI
DB14507 DRUGBANK_ID
5Z6E9K79YV UNII
DB14509 DRUGBANK_ID
203056 RXNORM
1994 MMSL
2001 MMSL
4987 MMSL
d00061 MMSL
001532 NDDF
001534 NDDF
17805003 SNOMEDCT_US
321719003 SNOMEDCT_US
387098001 SNOMEDCT_US
85899009 SNOMEDCT_US
C0125997 UMLSCUI
C0023870 UMLSCUI
D016651 MESH_DESCRIPTOR_UI
CHEMBL1201333 ChEMBL_ID
13520 PUBCHEM_CID
7439-93-2 SECONDARY_CAS_RN
3028194 PUBCHEM_CID
D008094 MESH_DESCRIPTOR_UI
9FN79X2M3F UNII
CHEBI:30145 CHEBI
5Z6E9K79YV INXIGHT DRUGS
9FN79X2M3F INXIGHT DRUGS

Pharmaceutical products:

ProductCategoryIngredientsNDCFormQuantityRouteMarketingLabel
Lithium HUMAN PRESCRIPTION DRUG LABEL 1 0054-3527 SOLUTION 8 meq ORAL NDA 26 sections
Lithium HUMAN PRESCRIPTION DRUG LABEL 1 0121-1027 SOLUTION 8 meq ORAL ANDA 27 sections
Lithium HUMAN PRESCRIPTION DRUG LABEL 1 0121-4027 SOLUTION 8 meq ORAL ANDA 27 sections
Lithium HUMAN PRESCRIPTION DRUG LABEL 1 68094-077 SOLUTION 8 meq ORAL ANDA 29 sections
Lithium HUMAN PRESCRIPTION DRUG LABEL 1 70518-4227 SOLUTION 8 meq ORAL ANDA 26 sections
Lithium HUMAN PRESCRIPTION DRUG LABEL 1 71656-072 SOLUTION 8 meq ORAL ANDA 27 sections
Lithium HUMAN PRESCRIPTION DRUG LABEL 1 72888-172 SOLUTION 8 meq ORAL ANDA 26 sections