All FDA-approved EMA-approved PMDA-approved
Target Card Uniprot Example: P23975

lithium citrate 🐶 Veterinary Use | Indications/Contra | FAERs-F | FAERs-M | Orange Bk | BioActivity |

Stem definition	Drug id	CAS RN
	4512	919-16-4

Description:

Molecule	Description
Synonyms: lithium citrate trilithium citrate lithonate lithium citrate hydrate	Molecular weight: 209.92 Formula: C6H5Li3O7 CLOGP: LIPINSKI: None HAC: None HDO: None TPSA: 140.62 ALOGS: ROTB: None

Drug dosage:

Dose	Unit	Route
24	mmol	O

ADMET properties:

None

Approvals:

Date	Agency	Company	Orphan
Dec. 23, 1980	FDA	ROXANE

FDA Adverse Event Reporting System (Female)

MedDRA adverse event term	Likelihood ratio	Likelihood ratio threshold	Patients taking drug having adverse event	Patients taking drug not having adverse event	Patients not taking drug having adverse event	Patients not taking drug not having adverse event
Toxicity to various agents	1391.65	13.37	1279	46226	245971	63195546
Nephrogenic diabetes insipidus	684.53	13.37	156	47349	803	63440714
Tremor	668.15	13.37	646	46859	131593	63309924
Neuroleptic malignant syndrome	643.85	13.37	266	47239	11790	63429727
Mania	560.97	13.37	243	47262	12124	63429393
Drug interaction	473.43	13.37	710	46795	228421	63213096
Hypomania	461.71	13.37	175	47330	6155	63435362
Psychotic disorder	429.02	13.37	257	47248	25455	63416062
Schizophrenia	382.07	13.37	174	47331	9778	63431739
Antipsychotic drug level increased	371.06	13.37	127	47378	3308	63438209
Completed suicide	361.58	13.37	493	47012	145180	63296337
Extrapyramidal disorder	345.81	13.37	178	47327	13106	63428411
Hyperparathyroidism	314.05	13.37	106	47399	2643	63438874
Tardive dyskinesia	299.34	13.37	140	47365	8362	63433155
Agitation	275.30	13.37	278	47227	59479	63382038
Suicidal ideation	266.94	13.37	279	47226	62142	63379375
Ataxia	264.14	13.37	156	47349	15039	63426478
Catatonia	260.19	13.37	105	47400	4372	63437145
Sedation	256.96	13.37	221	47284	38588	63402929
Bipolar disorder	222.69	13.37	112	47393	7848	63433669
Suicide attempt	221.51	13.37	250	47255	60668	63380849
Jaundice cholestatic	216.56	13.37	107	47398	7217	63434300
Serotonin syndrome	209.76	13.37	173	47332	28509	63413008
Pain	205.96	13.37	153	47352	740475	62701042
Akathisia	194.15	13.37	107	47398	9039	63432478
Diabetes insipidus	178.59	13.37	69	47436	2556	63438961
Antipsychotic drug level above therapeutic	175.60	13.37	54	47451	989	63440528
Pleurothotonus	173.96	13.37	57	47448	1292	63440225
Parkinsonism	167.99	13.37	102	47403	10337	63431180
Hypernatraemia	164.21	13.37	90	47415	7519	63433998
Overdose	161.05	13.37	300	47205	114778	63326739
Salivary hypersecretion	158.10	13.37	88	47417	7578	63433939
Drug level increased	157.66	13.37	133	47372	22603	63418914
Delusion	157.24	13.37	103	47402	11914	63429603
Delirium	156.39	13.37	191	47314	50350	63391167
Arthralgia	155.16	13.37	120	47385	569590	62871927
Aggression	151.82	13.37	132	47373	23366	63418151
Confusional state	150.72	13.37	453	47052	235927	63205590
Disorientation	148.66	13.37	165	47340	39287	63402230
Dysarthria	142.96	13.37	168	47337	42543	63398974
Infusion related reaction	142.05	13.37	11	47494	245510	63196007
Systemic lupus erythematosus	141.71	13.37	3	47502	208915	63232602
Rheumatoid arthritis	139.74	13.37	14	47491	253805	63187712
Somnolence	138.88	13.37	368	47137	178317	63263200
Muscle rigidity	137.05	13.37	93	47412	11407	63430110
Arthropathy	131.76	13.37	12	47493	234780	63206737
Hallucination, auditory	130.18	13.37	94	47411	12730	63428787
Swelling	128.66	13.37	25	47480	275353	63166164
Joint swelling	127.75	13.37	43	47462	327623	63113894
Polyuria	126.09	13.37	79	47426	8463	63433054
Irritability	125.38	13.37	136	47369	31558	63409959
Obsessive-compulsive disorder	122.06	13.37	60	47445	4000	63437517
Hyperreflexia	122.04	13.37	68	47437	5866	63435651
Nasopharyngitis	116.85	13.37	24	47481	254233	63187284
Disturbance in attention	115.99	13.37	143	47362	38046	63403471
Glossodynia	115.98	13.37	4	47501	178872	63262645
Myoclonus	114.51	13.37	95	47410	15773	63425744
Mental status changes	113.44	13.37	144	47361	39455	63402062
Intentional self-injury	111.85	13.37	116	47389	25571	63415946
Dyspnoea	110.07	13.37	205	47300	661108	62780409
Hypersensitivity	109.64	13.37	41	47464	292644	63148873
Alopecia	108.16	13.37	59	47446	337477	63104040
Intentional overdose	107.05	13.37	196	47309	73956	63367561
Abnormal behaviour	106.57	13.37	104	47401	21322	63420195
Paranoia	105.93	13.37	80	47425	11599	63429918
Hypothyroidism	103.57	13.37	143	47362	42489	63399028
Contraindicated product administered	103.25	13.37	19	47486	217629	63223888
Depression	99.29	13.37	348	47157	196144	63245373
Neurotoxicity	98.93	13.37	90	47415	16900	63424617
Mental disorder	91.82	13.37	105	47400	25814	63415703
Sinusitis	91.37	13.37	28	47477	226625	63214892
Polydipsia	90.54	13.37	47	47458	3517	63438000
Cholelithiasis	90.13	13.37	136	47369	43789	63397728
Bipolar I disorder	88.31	13.37	38	47467	1861	63439656
Electrocardiogram QT prolonged	88.00	13.37	159	47346	59371	63382146
Drug intolerance	86.41	13.37	63	47442	308598	63132919
Peripheral swelling	85.86	13.37	46	47459	265896	63175621
Asthma-chronic obstructive pulmonary disease overlap syndrome	85.32	13.37	38	47467	2023	63439494
Hepatotoxicity	85.14	13.37	121	47384	36920	63404597
Granulocytopenia	85.08	13.37	53	47452	5619	63435898
Abdominal discomfort	84.13	13.37	70	47435	320815	63120702
Antipsychotic drug level below therapeutic	83.11	13.37	23	47482	285	63441232
Fatigue	82.97	13.37	363	47142	887665	62553852
Blood bilirubin increased	81.96	13.37	119	47386	37021	63404496
Total lung capacity increased	81.18	13.37	38	47467	2272	63439245
Weight increased	80.53	13.37	397	47108	260395	63181122
Treatment noncompliance	80.06	13.37	118	47387	37207	63404310
Hypercalcaemia	79.54	13.37	102	47403	28220	63413297
Stomatitis	78.02	13.37	7	47498	138718	63302799
Libido increased	76.27	13.37	31	47474	1314	63440203
Rash	74.21	13.37	197	47308	560674	62880843
Euphoric mood	74.15	13.37	46	47459	4841	63436676
Camptocormia	73.92	13.37	21	47484	288	63441229
Dyskinesia	72.75	13.37	104	47401	31898	63409619
Dystonia	72.35	13.37	69	47436	13750	63427767
Sopor	72.18	13.37	86	47419	22078	63419439
Poisoning	70.95	13.37	68	47437	13632	63427885
Mutism	70.53	13.37	31	47474	1599	63439918
Parathyroid tumour benign	70.39	13.37	25	47480	728	63440789
Somatic symptom disorder	70.23	13.37	36	47469	2624	63438893
Nephropathy	70.17	13.37	49	47456	6292	63435225
Body tinea	69.32	13.37	32	47473	1853	63439664
Apathy	68.39	13.37	55	47450	8739	63432778
Cogwheel rigidity	67.97	13.37	32	47473	1938	63439579
Aphasia	67.44	13.37	102	47403	32898	63408619
Pruritus	67.35	13.37	104	47401	361349	63080168
Depressed mood	66.73	13.37	113	47392	40078	63401439
Grandiosity	65.56	13.37	19	47486	281	63441236
Anaemia	65.30	13.37	74	47431	293356	63148161
Inhibitory drug interaction	65.09	13.37	35	47470	2814	63438703
Drug abuse	64.18	13.37	157	47348	72361	63369156
Blood prolactin increased	63.59	13.37	37	47468	3466	63438051
Schizoaffective disorder	63.01	13.37	37	47468	3525	63437992
Infection	62.52	13.37	48	47457	229125	63212392
Restlessness	61.56	13.37	92	47413	29361	63412156
Psychomotor hyperactivity	61.13	13.37	56	47449	10607	63430910
Gastrointestinal disorder	61.05	13.37	12	47493	131227	63310290
Depressed level of consciousness	61.00	13.37	140	47365	61938	63379579
Postural tremor	58.36	13.37	18	47487	333	63441184
Back pain	58.35	13.37	67	47438	264078	63177439
Encephalopathy	58.14	13.37	104	47401	38516	63403001
Chronic kidney disease	58.06	13.37	114	47391	45284	63396233
Logorrhoea	57.80	13.37	31	47474	2479	63439038
Treatment failure	57.80	13.37	39	47466	199004	63242513
Pain in extremity	57.42	13.37	100	47405	331386	63110131
Resting tremor	57.29	13.37	22	47483	801	63440716
Hostility	57.28	13.37	28	47477	1844	63439673
Therapeutic product effect decreased	57.25	13.37	37	47468	193150	63248367
Brugada syndrome	56.58	13.37	18	47487	370	63441147
Anticholinergic syndrome	56.49	13.37	30	47475	2352	63439165
Blister	56.09	13.37	14	47491	129800	63311717
Altered state of consciousness	55.89	13.37	81	47424	25149	63416368
Anger	53.76	13.37	56	47449	12400	63429117
Impaired healing	53.02	13.37	7	47498	102535	63338982
Electrocardiogram T wave abnormal	52.95	13.37	29	47476	2418	63439099
Pressure of speech	52.67	13.37	20	47485	706	63440811
Tachyphrenia	52.64	13.37	24	47481	1350	63440167
Discomfort	52.46	13.37	30	47475	167344	63274173
Anxiety	52.06	13.37	309	47196	217232	63224285
Mood swings	51.67	13.37	66	47439	18182	63423335
Cough	50.97	13.37	88	47417	292655	63148862
Personality disorder	50.92	13.37	39	47466	5772	63435745
Product use issue	50.82	13.37	54	47451	220466	63221051
Infection susceptibility increased	50.55	13.37	32	47473	3489	63438028
Schizoaffective disorder bipolar type	49.60	13.37	13	47492	129	63441388
Nasal polyps	49.59	13.37	39	47466	6000	63435517
Stupor	49.57	13.37	34	47471	4241	63437276
Drug reaction with eosinophilia and systemic symptoms	49.51	13.37	90	47415	33746	63407771
Abdominal pain upper	49.33	13.37	49	47456	206395	63235122
Myocarditis	49.26	13.37	49	47456	10276	63431241
Febrile neutropenia	48.85	13.37	14	47491	118435	63323082
Glucose tolerance impaired	48.75	13.37	40	47465	6537	63434980
Leukocytosis	48.57	13.37	77	47428	25858	63415659
Blood creatine phosphokinase increased	48.46	13.37	84	47421	30346	63411171
Cardio-respiratory arrest	48.02	13.37	125	47380	59834	63381683
Disease progression	47.95	13.37	16	47489	122742	63318775
Mental impairment	47.88	13.37	56	47449	14095	63427422
Psychiatric symptom	47.86	13.37	36	47469	5187	63436330
Hallucination	47.77	13.37	118	47387	54699	63386818
Hyperprolactinaemia	47.56	13.37	32	47473	3868	63437649
Product tampering	47.27	13.37	16	47489	402	63441115
Withdrawal syndrome	46.94	13.37	66	47439	19931	63421586
Death	46.80	13.37	135	47370	374246	63067271
Neurological symptom	46.74	13.37	37	47468	5746	63435771
Action tremor	46.54	13.37	15	47490	322	63441195
Adulterated product	46.17	13.37	14	47491	244	63441273
Intentional product use issue	46.04	13.37	19	47486	127873	63313644
White blood cell count increased	46.04	13.37	108	47397	48453	63393064
Speech disorder	45.99	13.37	97	47408	40532	63400985
Atrial fibrillation	45.91	13.37	15	47490	116621	63324896
Psoriatic arthropathy	45.55	13.37	7	47498	91513	63350004
Soft tissue injury	45.48	13.37	23	47482	1629	63439888
Lethargy	45.09	13.37	117	47388	55890	63385627
Hypothermia	44.72	13.37	53	47452	13528	63427989
Arthritis	43.75	13.37	16	47489	115905	63325612
Galactorrhoea	43.41	13.37	31	47474	4124	63437393
Drooling	43.06	13.37	30	47475	3838	63437679
Claustrophobia	42.88	13.37	19	47486	999	63440518
Sleep-related eating disorder	42.79	13.37	18	47487	833	63440684
Fibromyalgia	42.77	13.37	5	47500	80415	63361102
Poor quality sleep	42.70	13.37	63	47442	19872	63421645
Renal cyst	42.12	13.37	45	47460	10257	63431260
Sarcoidosis	41.99	13.37	38	47467	7084	63434433
Diarrhoea	41.83	13.37	339	47166	715027	62726490
Amenorrhoea	41.76	13.37	44	47461	9870	63431647
Oculogyric crisis	41.73	13.37	22	47483	1699	63439818
Persecutory delusion	41.67	13.37	26	47479	2764	63438753
Substance abuse	41.55	13.37	32	47473	4775	63436742
Asterixis	40.05	13.37	20	47485	1379	63440138
Major depression	40.02	13.37	39	47466	7979	63433538
Urticaria	40.01	13.37	39	47466	165763	63275754
Goitre	39.53	13.37	34	47471	5927	63435590
Neutrophil count increased	39.47	13.37	55	47450	16472	63425045
Drug withdrawal syndrome	39.36	13.37	72	47433	27122	63414395
Thinking abnormal	39.19	13.37	44	47461	10599	63430918
Rhabdomyolysis	38.71	13.37	95	47410	43856	63397661
Hallucination, visual	38.51	13.37	59	47446	19239	63422278
Cerebellar atrophy	38.21	13.37	16	47489	732	63440785
Headache	37.95	13.37	298	47207	632943	62808574
Post-traumatic neck syndrome	37.89	13.37	22	47483	2052	63439465
Respiratory arrest	37.02	13.37	78	47427	32567	63408950
Asthma	37.01	13.37	25	47480	127536	63313981
Parkinsonian gait	36.58	13.37	14	47491	505	63441012
Sternal fracture	36.20	13.37	22	47483	2232	63439285
Clonus	36.06	13.37	29	47476	4607	63436910
Visuospatial deficit	36.05	13.37	7	47498	13	63441504
Enuresis	35.98	13.37	23	47482	2550	63438967
COVID-19	35.82	13.37	20	47485	113083	63328434
Lower respiratory tract infection	35.69	13.37	28	47477	132279	63309238
Cognitive disorder	35.48	13.37	107	47398	55708	63385809
Electroencephalogram abnormal	35.19	13.37	26	47479	3646	63437871
Muscle twitching	34.92	13.37	57	47448	19611	63421906
Impulsive behaviour	34.92	13.37	19	47486	1564	63439953
Blood sodium increased	34.72	13.37	23	47482	2709	63438808
Haemodialysis	34.68	13.37	38	47467	8909	63432608
Gastrointestinal haemorrhage	34.58	13.37	9	47496	81167	63360350
Bronchitis	34.26	13.37	26	47479	124909	63316608
Psychiatric decompensation	34.23	13.37	18	47487	1383	63440134
Electrocardiogram T wave inversion	34.15	13.37	25	47480	3456	63438061
Maternal exposure during pregnancy	34.03	13.37	71	47434	219991	63221526
Injection site erythema	33.98	13.37	10	47495	83164	63358353
Hyperlipidaemia	33.78	13.37	56	47449	19515	63422002
Drug level above therapeutic	33.07	13.37	28	47477	4777	63436740
Choreoathetosis	32.79	13.37	13	47492	516	63441001
Insomnia	32.25	13.37	273	47232	214979	63226538
Renal oncocytoma	32.15	13.37	7	47498	28	63441489
Myocardial oedema	31.60	13.37	10	47495	202	63441315
Hereditary ataxia	31.57	13.37	7	47498	31	63441486
Acute psychosis	31.47	13.37	21	47484	2504	63439013
Osteoarthritis	31.45	13.37	16	47489	95327	63346190
Cardiac murmur	31.19	13.37	46	47459	14506	63427011
Papillary thyroid cancer	31.14	13.37	20	47485	2236	63439281
General physical health deterioration	31.12	13.37	65	47440	201337	63240180
Affect lability	31.05	13.37	40	47465	11111	63430406
Rhinitis allergic	31.00	13.37	41	47464	11686	63429831
Hyperthyroidism	30.89	13.37	46	47459	14627	63426890
Social avoidant behaviour	30.54	13.37	22	47483	2966	63438551
Muscle injury	30.33	13.37	6	47499	65339	63376178
Ileus paralytic	30.26	13.37	26	47479	4525	63436992
Memory impairment	30.19	13.37	156	47349	104102	63337415
Acute kidney injury	29.94	13.37	315	47190	263100	63178417
Knee arthroplasty	29.76	13.37	3	47502	54203	63387314
Neuropathy peripheral	29.48	13.37	25	47480	113642	63327875
Bruxism	29.45	13.37	23	47482	3502	63438015
Bradykinesia	29.26	13.37	27	47478	5161	63436356
Behaviour disorder	29.20	13.37	22	47483	3177	63438340
Eye movement disorder	29.08	13.37	27	47478	5201	63436316
Mobility decreased	28.64	13.37	29	47476	121130	63320387
Depressive symptom	28.43	13.37	24	47481	4078	63437439
Musculoskeletal pain	28.25	13.37	17	47488	92260	63349257
Self-injurious ideation	28.15	13.37	20	47485	2639	63438878
Nodal rhythm	27.96	13.37	17	47488	1726	63439791
Pulse abnormal	27.88	13.37	19	47486	2345	63439172
Bradyphrenia	27.68	13.37	30	47475	6950	63434567
Myoclonic epilepsy	27.52	13.37	15	47490	1239	63440278
Brain injury	27.45	13.37	30	47475	7013	63434504
Suspected suicide	27.40	13.37	29	47476	6539	63434978
Mydriasis	27.38	13.37	39	47466	11917	63429600
Purpura	27.35	13.37	38	47467	11347	63430170
Impaired self-care	26.86	13.37	17	47488	1853	63439664
Drug hypersensitivity	26.44	13.37	131	47374	310556	63130961
Lung disorder	26.34	13.37	7	47498	62254	63379263
Ammonia increased	25.81	13.37	24	47481	4632	63436885
Chest pain	25.42	13.37	80	47425	215879	63225638
Abdominal pain	25.39	13.37	123	47382	293333	63148184
Hypotonia	25.37	13.37	33	47472	9252	63432265
Ill-defined disorder	25.11	13.37	15	47490	81740	63359777
Hallucinations, mixed	25.06	13.37	24	47481	4805	63436712
Neuropsychiatric symptoms	24.97	13.37	12	47493	761	63440756
Feeling guilty	24.96	13.37	11	47494	571	63440946
Sepsis	24.86	13.37	48	47457	153075	63288442
Differential white blood cell count abnormal	24.78	13.37	12	47493	774	63440743
Thrombosis	24.32	13.37	9	47496	64746	63376771
Delusion of reference	24.31	13.37	7	47498	101	63441416
International normalised ratio abnormal	24.29	13.37	20	47485	3284	63438233
Ideas of reference	24.19	13.37	7	47498	103	63441414
Judgement impaired	24.13	13.37	12	47493	820	63440697
Irritable bowel syndrome	24.10	13.37	16	47489	82396	63359121
Cerebral atrophy	24.09	13.37	24	47481	5042	63436475
Antidepressant drug level increased	23.99	13.37	9	47496	307	63441210
Hypertonia	23.98	13.37	23	47482	4614	63436903
Polyhydramnios	23.85	13.37	17	47488	2254	63439263
Thyrotoxic crisis	23.55	13.37	12	47493	864	63440653
Adams-Stokes syndrome	23.52	13.37	6	47499	53	63441464
Injection site pruritus	23.51	13.37	3	47502	45113	63396404
Anaphylactic reaction	23.49	13.37	10	47495	66090	63375427
Hyperammonaemia	23.44	13.37	24	47481	5208	63436309
Histrionic personality disorder	23.42	13.37	6	47499	54	63441463
Nystagmus	23.39	13.37	26	47479	6194	63435323
Cardiac arrest	23.10	13.37	133	47372	92412	63349105
Cerebellar syndrome	23.09	13.37	20	47485	3519	63437998
Muscle contractions involuntary	23.06	13.37	17	47488	2375	63439142
Flat affect	22.89	13.37	14	47491	1436	63440081
Urinary incontinence	22.87	13.37	64	47441	31950	63409567
Injection site swelling	22.86	13.37	4	47501	47568	63393949
Electroconvulsive therapy	22.76	13.37	6	47499	61	63441456
Hyperthermia	22.66	13.37	31	47474	9125	63432392
Injection site pain	22.57	13.37	39	47466	129761	63311756
Refusal of treatment by patient	22.45	13.37	24	47481	5473	63436044
Oxygen saturation decreased	22.34	13.37	20	47485	88565	63352952
Cerebrovascular accident	22.13	13.37	29	47476	107995	63333522
CSWS syndrome	22.05	13.37	5	47500	25	63441492
Cardiac failure congestive	21.99	13.37	22	47483	92411	63349106
Affective disorder	21.93	13.37	25	47480	6121	63435396
Impaired quality of life	21.88	13.37	38	47467	13745	63427772
Blunted affect	21.84	13.37	8	47497	255	63441262
Nephropathy toxic	21.82	13.37	31	47474	9448	63432069
Gestational diabetes	21.65	13.37	29	47476	8367	63433150
Cardiac hypertrophy	21.55	13.37	12	47493	1033	63440484
Bone pain	21.54	13.37	7	47498	54634	63386883
Influenza	21.45	13.37	30	47475	108692	63332825
Drug level decreased	21.41	13.37	28	47477	7891	63433626
Staring	21.39	13.37	14	47491	1616	63439901
Platelet count decreased	21.02	13.37	34	47471	116088	63325429
Seizure	20.80	13.37	170	47335	132464	63309053
Lactate pyruvate ratio increased	20.62	13.37	6	47499	90	63441427
Coordination abnormal	20.61	13.37	37	47468	13736	63427781
Thyroiditis	20.41	13.37	16	47489	2450	63439067
Mucosal inflammation	20.38	13.37	5	47500	46923	63394594
Productive cough	20.27	13.37	11	47494	63197	63378320
Rebound psychosis	20.14	13.37	7	47498	191	63441326
Dyspnoea exertional	20.07	13.37	10	47495	60292	63381225
International normalised ratio increased	20.05	13.37	5	47500	46420	63395097
Limbic encephalitis	20.05	13.37	8	47497	323	63441194
Electrocardiogram abnormal	19.65	13.37	29	47476	9150	63432367
Dialysis	19.58	13.37	31	47474	10396	63431121
Hyporeflexia	19.48	13.37	14	47491	1881	63439636
Metabolic syndrome	19.29	13.37	13	47492	1575	63439942
Human herpesvirus 6 infection reactivation	19.10	13.37	8	47497	366	63441151
Dysphoria	19.09	13.37	21	47484	4945	63436572
Slow response to stimuli	18.99	13.37	11	47494	1021	63440496
Bundle branch block right	18.98	13.37	21	47484	4977	63436540
Toxic encephalopathy	18.95	13.37	24	47481	6555	63434962
Arachnoid cyst	18.94	13.37	7	47498	229	63441288
Unresponsive to stimuli	18.88	13.37	62	47443	33754	63407763
Ear infection	18.84	13.37	3	47502	38210	63403307
Mood altered	18.82	13.37	37	47468	14706	63426811
Rhinorrhoea	18.81	13.37	13	47492	65564	63375953
Lipids decreased	18.79	13.37	4	47501	14	63441503
Borderline personality disorder	18.63	13.37	10	47495	801	63440716
Urine osmolarity increased	18.56	13.37	6	47499	130	63441387
Decreased appetite	18.51	13.37	111	47394	250941	63190576
Cystitis	18.48	13.37	9	47496	54982	63386535
Essential tremor	18.46	13.37	11	47494	1077	63440440
Blood citric acid increased	18.29	13.37	5	47500	59	63441458
Compulsive sexual behaviour	18.29	13.37	5	47500	59	63441458
Oscillopsia	18.27	13.37	6	47499	137	63441380
Negativism	18.27	13.37	8	47497	409	63441108
Acquired cystic kidney disease	18.14	13.37	5	47500	61	63441456
Homicidal ideation	18.14	13.37	13	47492	1739	63439778
Pleural effusion	18.11	13.37	26	47479	93184	63348333
Sluggishness	18.07	13.37	21	47484	5248	63436269
Concussion	18.07	13.37	28	47477	9216	63432301
Consciousness fluctuating	18.00	13.37	10	47495	857	63440660
Inflammation	17.99	13.37	21	47484	82252	63359265
Sinus bradycardia	17.95	13.37	36	47469	14515	63427002
Antidepressant drug level above therapeutic	17.91	13.37	8	47497	429	63441088
Skin ulcer	17.90	13.37	5	47500	43040	63398477
Merycism	17.75	13.37	7	47498	274	63441243
Clear cell renal cell carcinoma	17.67	13.37	12	47493	1473	63440044
Bronchiectasis	17.64	13.37	38	47467	16104	63425413
Suicidal behaviour	17.39	13.37	15	47490	2624	63438893
Epileptic encephalopathy	17.37	13.37	7	47498	290	63441227
Body mass index increased	17.29	13.37	11	47494	1209	63440308
Flight of ideas	17.28	13.37	8	47497	466	63441051
Compartment syndrome	17.16	13.37	14	47491	2270	63439247
Blood pressure systolic increased	17.12	13.37	7	47498	47390	63394127
Musculoskeletal stiffness	16.77	13.37	76	47429	184542	63256975
Tooth injury	16.72	13.37	11	47494	1281	63440236
Tonsillar hypertrophy	16.67	13.37	10	47495	991	63440526
Paroxysmal perceptual alteration	16.52	13.37	3	47502	3	63441514
Acalculia	16.52	13.37	3	47502	3	63441514
Ascites	16.44	13.37	5	47500	40723	63400794
Colitis	16.22	13.37	8	47497	48520	63392997
Choluria	16.13	13.37	6	47499	200	63441317
Paraesthesia	15.87	13.37	62	47443	156904	63284613
Gaze palsy	15.77	13.37	11	47494	1409	63440108
Septic shock	15.68	13.37	16	47489	66613	63374904
Status epilepticus	15.67	13.37	35	47470	15198	63426319
Impaired work ability	15.62	13.37	38	47467	17437	63424080
Hypokalaemia	15.60	13.37	34	47471	103770	63337747
Urinary retention	15.55	13.37	54	47451	30247	63411270
Echolalia	15.48	13.37	6	47499	224	63441293
Neonatal respiratory distress	15.45	13.37	7	47498	388	63441129
Hyperparathyroidism primary	15.37	13.37	7	47498	393	63441124
Malaise	15.35	13.37	219	47286	415735	63025782
Pneumonia	15.31	13.37	245	47260	456522	62984995
Weight decreased	15.26	13.37	133	47372	276665	63164852
Middle insomnia	15.26	13.37	31	47474	12612	63428905
Dysphemia	15.24	13.37	14	47491	2661	63438856
Thrombocytopenia	15.10	13.37	60	47445	151097	63290420
Sleep apnoea syndrome	15.02	13.37	52	47453	29081	63412436
Haemoglobin decreased	15.01	13.37	57	47448	145428	63296089
Joint range of motion decreased	15.00	13.37	3	47502	32425	63409092
Cerebellar ataxia	14.99	13.37	9	47496	893	63440624
Delusional perception	14.97	13.37	6	47499	245	63441272
Glomerulonephritis minimal lesion	14.88	13.37	6	47499	249	63441268
Upper respiratory tract infection	14.87	13.37	24	47481	82023	63359494
Posture abnormal	14.85	13.37	13	47492	2319	63439198
Pain in jaw	14.80	13.37	7	47498	43489	63398028
Balance disorder	14.77	13.37	111	47394	84311	63357206
Stereotypy	14.70	13.37	7	47498	435	63441082
Hyperhidrosis	14.69	13.37	134	47371	107702	63333815
Nuchal rigidity	14.67	13.37	8	47497	661	63440856
Distractibility	14.67	13.37	7	47498	437	63441080
Increased appetite	14.57	13.37	26	47479	9604	63431913
Throat irritation	14.53	13.37	5	47500	37642	63403875
Loss of personal independence in daily activities	14.51	13.37	32	47473	97258	63344259
Thought insertion	14.44	13.37	3	47502	9	63441508
Psychotic disorder due to a general medical condition	14.42	13.37	6	47499	270	63441247
Cardiac failure	14.41	13.37	28	47477	89114	63352403
Bone density decreased	14.39	13.37	33	47472	14579	63426938
Unmasking of previously unidentified disease	14.34	13.37	9	47496	967	63440550
Movement disorder	14.21	13.37	42	47463	21619	63419898
Neutrophilia	14.18	13.37	17	47488	4389	63437128
Restless legs syndrome	14.18	13.37	38	47467	18493	63423024
Dry skin	14.16	13.37	13	47492	56874	63384643
Atrioventricular block second degree	14.10	13.37	16	47489	3898	63437619
Amimia	14.07	13.37	4	47501	55	63441462
Haemorrhage	13.97	13.37	15	47490	61007	63380510
Abulia	13.97	13.37	7	47498	486	63441031
Agranulocytosis	13.96	13.37	46	47459	25088	63416429
Radial nerve palsy	13.83	13.37	7	47498	497	63441020
Incoherent	13.80	13.37	17	47488	4513	63437004
Skin disorder	13.79	13.37	51	47454	29456	63412061
Femur fracture	13.78	13.37	7	47498	41749	63399768
Thought blocking	13.66	13.37	5	47500	159	63441358
Urine output increased	13.66	13.37	10	47495	1383	63440134
Melaena	13.65	13.37	3	47502	30362	63411155
Respiratory tract infection	13.62	13.37	7	47498	41476	63400041
Haematochezia	13.61	13.37	12	47493	53532	63387985
Decreased activity	13.57	13.37	20	47485	6300	63435217

FDA Adverse Event Reporting System (Male)

MedDRA adverse event term	Likelihood ratio	Likelihood ratio threshold	Patients taking drug having adverse event	Patients taking drug not having adverse event	Patients not taking drug having adverse event	Patients not taking drug not having adverse event
Toxicity to various agents	907.15	14.34	1088	36183	199274	34720386
Neuroleptic malignant syndrome	610.44	14.34	323	36948	17611	34902049
Mania	505.01	14.34	232	37039	9279	34910381
Nephrogenic diabetes insipidus	464.42	14.34	131	37140	1190	34918470
Tremor	437.85	14.34	488	36783	82099	34837561
Antipsychotic drug level increased	365.02	14.34	142	37129	3723	34915937
Akathisia	327.59	14.34	164	37107	7945	34911715
Suicide attempt	276.71	14.34	270	37001	38846	34880814
Obsessive-compulsive disorder	271.30	14.34	128	37143	5436	34914224
Extrapyramidal disorder	261.75	14.34	166	37105	12714	34906946
Antipsychotic drug level below therapeutic	256.26	14.34	98	37173	2449	34917211
Psychotic disorder	254.65	14.34	210	37061	24242	34895418
Drug interaction	235.34	14.34	647	36624	225299	34694361
Parkinsonism	219.99	14.34	126	37145	8012	34911648
Schizophrenia	197.08	14.34	120	37151	8546	34911114
Serotonin syndrome	192.64	14.34	164	37107	19769	34899891
Antipsychotic drug level above therapeutic	189.92	14.34	65	37206	1168	34918492
Suicidal ideation	179.04	14.34	218	37053	40170	34879490
Hallucination, auditory	175.95	14.34	126	37145	11791	34907869
Sedation	173.33	14.34	158	37113	20848	34898812
Euphoric mood	173.29	14.34	95	37176	5546	34914114
Disinhibition	168.98	14.34	78	37193	3148	34916512
Therapeutic product effect variable	159.41	14.34	69	37202	2387	34917273
Increased appetite	159.07	14.34	99	37172	7330	34912330
Agitation	152.34	14.34	242	37029	57157	34862503
Aggression	151.49	14.34	197	37074	38767	34880893
Granulocytopenia	149.48	14.34	91	37180	6476	34913184
Weight increased	146.49	14.34	313	36958	92720	34826940
Completed suicide	146.29	14.34	323	36948	97845	34821815
Hypomania	145.71	14.34	64	37207	2295	34917365
Irritability	135.81	14.34	149	37122	24541	34895119
Diabetes insipidus	135.51	14.34	65	37206	2863	34916797
Psychomotor hyperactivity	126.80	14.34	95	37176	9527	34910133
Leukopenia	113.65	14.34	224	37047	62632	34857028
Salivary hypersecretion	113.14	14.34	85	37186	8559	34911101
Dysarthria	112.67	14.34	161	37110	34621	34885039
Febrile neutropenia	109.35	14.34	10	37261	136839	34782821
Dyspnoea	107.82	14.34	147	37124	376635	34543025
Bipolar disorder	105.05	14.34	59	37212	3610	34916050
Delusion of grandeur	103.80	14.34	41	37230	1119	34918541
Tardive dyskinesia	101.38	14.34	68	37203	5722	34913938
Overdose	100.58	14.34	267	37004	90792	34828868
Neutrophil count increased	100.45	14.34	107	37164	17039	34902621
Dyskinesia	97.67	14.34	120	37151	22293	34897367
Muscle rigidity	96.43	14.34	84	37187	10434	34909226
Delusion	94.48	14.34	90	37181	12545	34907115
Abnormal behaviour	93.53	14.34	124	37147	24845	34894815
Ataxia	92.97	14.34	93	37178	13760	34905900
Death	92.56	14.34	178	37093	397871	34521789
Arthralgia	89.02	14.34	35	37236	170006	34749654
Schizoaffective disorder	88.47	14.34	38	37233	1289	34918371
Hypernatraemia	86.41	14.34	72	37199	8418	34911242
Priapism	83.49	14.34	57	37214	4937	34914723
Bruxism	81.76	14.34	39	37232	1696	34917964
Confusional state	81.72	14.34	337	36934	143823	34775837
Catatonia	80.81	14.34	56	37215	4969	34914691
Myoclonus	79.46	14.34	88	37183	14637	34905023
Anaemia	77.27	14.34	81	37190	233254	34686406
Oppositional defiant disorder	77.04	14.34	27	37244	522	34919138
Mental status changes	76.52	14.34	142	37129	37941	34881719
Coordination abnormal	76.09	14.34	64	37207	7580	34912080
White blood cell count increased	75.97	14.34	148	37123	41003	34878657
Affective disorder	75.84	14.34	51	37220	4309	34915351
Hyperparathyroidism	74.92	14.34	33	37238	1191	34918469
Cough	73.62	14.34	34	37237	150106	34769554
Decreased eye contact	71.99	14.34	25	37246	470	34919190
Delirium	70.27	14.34	149	37122	43842	34875818
Homicidal ideation	68.41	14.34	40	37231	2642	34917018
Myocarditis	67.41	14.34	78	37193	13604	34906056
Pain	66.68	14.34	72	37199	204603	34715057
Malignant neoplasm progression	66.27	14.34	8	37263	88038	34831622
Obesity	66.12	14.34	75	37196	12803	34906857
Dystonia	65.86	14.34	69	37202	10776	34908884
Dyslipidaemia	63.06	14.34	57	37214	7431	34912229
Pain in extremity	63.02	14.34	28	37243	126485	34793175
Electrocardiogram QRS complex prolonged	61.55	14.34	47	37224	4847	34914813
Cognitive disorder	61.45	14.34	110	37161	28583	34891077
Treatment noncompliance	60.53	14.34	108	37163	27992	34891668
Pneumonia	60.05	14.34	193	37078	362434	34557226
Intentional overdose	59.69	14.34	139	37132	43535	34876125
Hyperreflexia	59.38	14.34	39	37232	3167	34916493
Neurotoxicity	59.23	14.34	84	37187	17926	34901734
Pancytopenia	57.88	14.34	15	37256	95142	34824518
Affect lability	56.79	14.34	40	37231	3643	34916017
Restlessness	54.96	14.34	98	37173	25384	34894276
Brugada syndrome	53.61	14.34	23	37248	778	34918882
Depression	53.39	14.34	225	37046	96873	34822787
Pruritus	53.17	14.34	44	37227	141937	34777723
Dystonic tremor	51.87	14.34	16	37255	203	34919457
Interstitial lung disease	51.49	14.34	5	37266	65277	34854383
Prescribed overdose	51.28	14.34	60	37211	10587	34909073
Back pain	50.41	14.34	34	37237	121755	34797905
Clonus	49.83	14.34	33	37238	2717	34916943
Anxiety	49.78	14.34	224	37047	99204	34820456
Atrial fibrillation	49.56	14.34	35	37236	122358	34797302
Hyperprolactinaemia	49.35	14.34	27	37244	1569	34918091
Thinking abnormal	48.33	14.34	45	37226	6092	34913568
Somnolence	48.10	14.34	240	37031	110876	34808784
Polydipsia	47.92	14.34	37	37234	3878	34915782
Disorientation	46.85	14.34	107	37164	33081	34886579
Peripheral swelling	46.67	14.34	12	37259	76529	34843131
Depressed level of consciousness	46.60	14.34	125	37146	42716	34876944
General physical health deterioration	46.49	14.34	41	37230	128228	34791432
Lethargy	45.76	14.34	121	37150	41001	34878659
Speech disorder	45.72	14.34	91	37180	25595	34894065
Rhinalgia	44.59	14.34	22	37249	1031	34918629
Failure to suspend medication	44.58	14.34	17	37254	421	34919239
Rash	43.05	14.34	110	37161	222642	34697018
Mental disorder	42.89	14.34	66	37205	15143	34904517
Sepsis	42.58	14.34	70	37201	166491	34753169
Septic shock	42.40	14.34	12	37259	71822	34847838
Disease progression	42.33	14.34	32	37239	108045	34811615
Thrombocytopenia	41.51	14.34	64	37207	156183	34763477
Choreoathetosis	41.43	14.34	21	37250	1043	34918617
Oedema peripheral	41.40	14.34	40	37231	119772	34799888
Blood creatine phosphokinase increased	41.09	14.34	123	37148	44734	34874926
Cardiac failure congestive	40.56	14.34	19	37252	83251	34836409
Insomnia	40.50	14.34	218	37053	103689	34815971
Electrocardiogram QT prolonged	40.10	14.34	115	37156	40837	34878823
Enuresis	39.67	14.34	27	37244	2326	34917334
Infusion related reaction	39.48	14.34	5	37266	53052	34866608
Abulia	39.40	14.34	17	37254	583	34919077
Leukocytosis	38.97	14.34	82	37189	23983	34895677
Mental impairment	38.23	14.34	51	37220	10271	34909389
Paranoia	37.79	14.34	55	37216	12013	34907647
Drug level above therapeutic	36.99	14.34	33	37238	4228	34915432
Blood thyroid stimulating hormone decreased	36.89	14.34	24	37247	1917	34917743
Apathy	36.65	14.34	41	37230	6891	34912769
Antipsychotic drug level decreased	36.50	14.34	19	37252	998	34918662
Hypothyroidism	35.94	14.34	73	37198	20829	34898831
Fatigue	35.82	14.34	240	37031	370413	34549247
Pressure of speech	35.74	14.34	15	37256	480	34919180
Nephropathy	34.77	14.34	37	37234	5880	34913780
Grandiosity	34.36	14.34	13	37258	315	34919345
Hyperparathyroidism primary	34.22	14.34	11	37260	161	34919499
Plasma cell myeloma	33.73	14.34	3	37268	42034	34877626
Trismus	33.68	14.34	25	37246	2470	34917190
Joint swelling	33.55	14.34	11	37260	59879	34859781
Distractibility	32.70	14.34	13	37258	361	34919299
Depressed mood	32.66	14.34	67	37204	19250	34900410
Bipolar I disorder	32.01	14.34	16	37255	771	34918889
Myocardial infarction	31.76	14.34	50	37221	121035	34798625
Hyperkinesia	31.51	14.34	21	37250	1747	34917913
Decreased appetite	31.48	14.34	83	37188	166309	34753351
Leukaemia	31.06	14.34	31	37240	4572	34915088
Ascites	31	14.34	6	37265	46565	34873095
Cardiac failure	30.89	14.34	31	37240	91217	34828443
Thrombosis	30.58	14.34	8	37263	50450	34869210
Headache	30.24	14.34	111	37160	200524	34719136
Logorrhoea	29.85	14.34	23	37248	2403	34917257
Drug level increased	29.82	14.34	70	37201	22026	34897634
Muscle spasms	29.62	14.34	22	37249	74979	34844681
Infection	29.53	14.34	32	37239	90883	34828777
Flight of ideas	29.16	14.34	12	37259	365	34919295
Epistaxis	28.81	14.34	13	37258	58238	34861422
Lymphocyte count abnormal	28.28	14.34	17	37254	1181	34918479
Eosinophil count decreased	27.99	14.34	18	37253	1410	34918250
Sexual dysfunction	27.85	14.34	34	37237	6269	34913391
Abdominal pain	27.73	14.34	86	37185	163532	34756128
Therapeutic product effect incomplete	27.65	14.34	117	37154	50424	34869236
Disturbance in attention	27.50	14.34	75	37196	25870	34893790
Anger	27.30	14.34	47	37224	11837	34907823
Intentional product use issue	27.10	14.34	15	37256	59801	34859859
Patient restraint	27.06	14.34	8	37263	87	34919573
Blood prolactin increased	26.87	14.34	19	37252	1741	34917919
Diabetes mellitus	26.81	14.34	110	37161	46763	34872897
Polyuria	26.73	14.34	39	37232	8535	34911125
Prostate cancer	26.62	14.34	5	37266	39644	34880016
Blood sodium increased	26.61	14.34	23	37248	2825	34916835
Tachycardia	26.61	14.34	168	37103	84604	34835056
Blunted affect	26.30	14.34	11	37260	349	34919311
Psychiatric decompensation	26.00	14.34	23	37248	2914	34916746
Defect conduction intraventricular	25.95	14.34	11	37260	361	34919299
Erythema	25.89	14.34	34	37237	88746	34830914
Gastrointestinal haemorrhage	25.69	14.34	34	37237	88443	34831217
Diarrhoea	25.31	14.34	280	36991	389632	34530028
Coronary artery disease	25.14	14.34	10	37261	48295	34871365
Acute myocardial infarction	25.02	14.34	13	37258	53706	34865954
Crying	24.90	14.34	31	37240	5831	34913829
Abdominal distension	24.63	14.34	16	37255	58476	34861184
Angioedema	24.49	14.34	5	37266	37369	34882291
Haemoptysis	24.41	14.34	4	37267	35002	34884658
Cerebral haemorrhage	24.34	14.34	4	37267	34933	34884727
Diabetic coma	24.24	14.34	14	37257	903	34918757
Feelings of worthlessness	24.15	14.34	10	37261	309	34919351
Mood altered	24.06	14.34	38	37233	8914	34910746
Cogwheel rigidity	23.96	14.34	16	37255	1336	34918324
Blood triglycerides increased	23.80	14.34	49	37222	14110	34905550
Cerebellar syndrome	23.77	14.34	20	37251	2368	34917292
Urticaria	23.73	14.34	19	37252	62358	34857302
Seizure	23.72	14.34	192	37079	104665	34814995
Weight decreased	23.72	14.34	102	37169	176199	34743461
Oxygen saturation decreased	23.66	14.34	14	37257	53804	34865856
Sleep disorder	23.64	14.34	81	37190	31607	34888053
Pneumonitis	23.33	14.34	4	37267	33874	34885786
Drooling	23.23	14.34	23	37248	3359	34916301
Arthritis	23.20	14.34	3	37268	31343	34888317
Self-injurious ideation	23.01	14.34	17	37254	1667	34917993
Pleural effusion	23	14.34	32	37239	81514	34838146
Long QT syndrome	22.94	14.34	21	37250	2782	34916878
Productive cough	22.90	14.34	6	37265	37807	34881853
Oromandibular dystonia	22.81	14.34	11	37260	490	34919170
Psychotic symptom	22.49	14.34	17	37254	1726	34917934
Metabolic encephalopathy	22.03	14.34	25	37246	4267	34915393
Haemorrhage	21.70	14.34	14	37257	51356	34868304
Conduction disorder	21.69	14.34	18	37253	2092	34917568
Musculoskeletal pain	21.52	14.34	4	37267	31959	34887701
Chest discomfort	21.52	14.34	16	37255	54514	34865146
Hypersensitivity	21.51	14.34	20	37251	61015	34858645
Renal cyst	20.93	14.34	36	37235	9057	34910603
Otospondylomegaepiphyseal dysplasia	20.92	14.34	7	37264	117	34919543
Melaena	20.71	14.34	6	37265	35374	34884286
Metabolic syndrome	20.67	14.34	16	37255	1683	34917977
Autonomic nervous system imbalance	20.66	14.34	19	37252	2532	34917128
Agranulocytosis	20.57	14.34	64	37207	23757	34895903
Stupor	20.49	14.34	20	37251	2871	34916789
High-grade B-cell lymphoma	20.34	14.34	7	37264	128	34919532
Persistent depressive disorder	20.25	14.34	9	37262	332	34919328
Stomatitis	20.23	14.34	10	37261	42504	34877156
Hyperammonaemic encephalopathy	20.18	14.34	18	37253	2306	34917354
Wrong patient received product	20.01	14.34	19	37252	2635	34917025
Cerebral amyloid angiopathy	19.99	14.34	7	37264	135	34919525
Hepatic failure	19.94	14.34	6	37265	34525	34885135
Anaphylactic reaction	19.80	14.34	5	37266	32296	34887364
Hyperkalaemia	19.80	14.34	27	37244	69362	34850298
Multiple organ dysfunction syndrome	19.70	14.34	32	37239	76534	34843126
Cerebrovascular accident	19.52	14.34	38	37233	84773	34834887
Poor quality sleep	19.42	14.34	33	37238	8223	34911437
Dyspnoea exertional	19.39	14.34	11	37260	43268	34876392
Dysphemia	19.36	14.34	15	37256	1580	34918080
Antipsychotic drug level	19.34	14.34	4	37267	7	34919653
Oncocytoma	19.34	14.34	4	37267	7	34919653
Mutism	19.34	14.34	12	37259	883	34918777
Accidental death	19.32	14.34	18	37253	2438	34917222
Convulsive threshold lowered	19.16	14.34	10	37261	528	34919132
Restless legs syndrome	19.13	14.34	33	37238	8321	34911339
Speech sound disorder	19.13	14.34	7	37264	154	34919506
Memory impairment	19.02	14.34	94	37177	43224	34876436
Intentional self-injury	18.99	14.34	44	37227	13727	34905933
Arthropathy	18.92	14.34	3	37268	26904	34892756
Staphylococcal infection	18.37	14.34	6	37265	32754	34886906
Gait disturbance	18.23	14.34	154	37117	84986	34834674
Kidney enlargement	18.08	14.34	11	37260	781	34918879
Nephrolithiasis	18.02	14.34	5	37266	30328	34889332
Secondary tic	17.85	14.34	4	37267	12	34919648
Upper gastrointestinal haemorrhage	17.60	14.34	3	37268	25515	34894145
Pyrexia	17.50	14.34	250	37021	332763	34586897
Altered state of consciousness	17.50	14.34	59	37212	22834	34896826
Hallucination, olfactory	17.45	14.34	7	37264	199	34919461
Withdrawal syndrome	17.40	14.34	40	37231	12415	34907245
Libido increased	17.36	14.34	11	37260	840	34918820
Blood thyroid stimulating hormone increased	17.28	14.34	22	37249	4233	34915427
Drug ineffective	17.19	14.34	621	36650	456130	34463530
Angina pectoris	17.14	14.34	6	37265	31357	34888303
Bone marrow failure	17.05	14.34	5	37266	29248	34890412
Schizoaffective disorder bipolar type	16.93	14.34	6	37265	120	34919540
Drug hypersensitivity	16.92	14.34	38	37233	80491	34839169
Social anxiety disorder	16.90	14.34	8	37263	342	34919318
Herpes zoster	16.51	14.34	8	37263	34391	34885269
Dysphoria	16.45	14.34	16	37255	2286	34917374
Thought blocking	16.35	14.34	6	37265	133	34919527
Bipolar II disorder	16.07	14.34	4	37267	21	34919639
Drug withdrawal syndrome	15.95	14.34	52	37219	19782	34899878
Gastrectomy	15.83	14.34	6	37265	146	34919514
Toxic cardiomyopathy	15.70	14.34	7	37264	260	34919400
Bronchitis	15.69	14.34	13	37258	41950	34877710
Urinary incontinence	15.64	14.34	50	37221	18824	34900836
Haematoma	15.63	14.34	4	37267	25601	34894059
Electrocardiogram abnormal	15.54	14.34	32	37239	9215	34910445
Acarodermatitis	15.49	14.34	8	37263	413	34919247
Cerebral infarction	15.44	14.34	5	37266	27450	34892210
Muscle twitching	15.42	14.34	34	37237	10264	34909396
Impulsive behaviour	15.40	14.34	15	37256	2147	34917513
Metastases to eye	15.32	14.34	5	37266	77	34919583
Blood pressure fluctuation	15.30	14.34	4	37267	25245	34894415
Sinusitis	15.26	14.34	13	37258	41389	34878271
Hypoxia	15.15	14.34	22	37249	55073	34864587
Encephalopathy	15.05	14.34	76	37195	35243	34884417
International normalised ratio increased	14.98	14.34	17	37254	47310	34872350
Abdominal pain upper	14.80	14.34	34	37237	71456	34848204
Electroconvulsive therapy	14.74	14.34	4	37267	31	34919629
Paradoxical drug reaction	14.68	14.34	18	37253	3333	34916327
Neutrophilia	14.65	14.34	20	37251	4117	34915543
Coma	14.61	14.34	91	37180	45587	34874073
Blood creatinine increased	14.50	14.34	160	37111	94816	34824844

FDA Adverse Event Reporting System (Geriatric)

MedDRA adverse event term	Likelihood ratio	Likelihood ratio threshold	Patients taking drug having adverse event	Patients taking drug not having adverse event	Patients not taking drug having adverse event	Patients not taking drug not having adverse event
Toxicity to various agents	2032.27	13.02	2167	68772	419373	79254076
Neuroleptic malignant syndrome	1128.39	13.02	531	70408	27028	79646421
Nephrogenic diabetes insipidus	1056.05	13.02	267	70672	1867	79671582
Tremor	1007.08	13.02	980	69959	169103	79504346
Mania	828.81	13.02	378	70561	17882	79655567
Drug interaction	666.16	13.02	1264	69675	413919	79259530
Antipsychotic drug level increased	631.57	13.02	227	70712	5730	79667719
Psychotic disorder	579.90	13.02	395	70544	41007	79632442
Hypomania	568.81	13.02	224	70715	7320	79666129
Extrapyramidal disorder	563.21	13.02	312	70627	22367	79651082
Schizophrenia	533.52	13.02	265	70674	15175	79658274
Completed suicide	482.52	13.02	818	70121	244949	79428500
Hyperparathyroidism	395.69	13.02	137	70802	3087	79670362
Serotonin syndrome	391.85	13.02	323	70616	44704	79628745
Agitation	376.93	13.02	454	70485	99261	79574188
Suicidal ideation	362.10	13.02	391	70548	75949	79597500
Ataxia	360.30	13.02	243	70696	24796	79648653
Akathisia	355.67	13.02	192	70747	13067	79660382
Antipsychotic drug level above therapeutic	345.39	13.02	111	70828	1969	79671480
Suicide attempt	340.58	13.02	394	70545	82538	79590911
Sedation	328.92	13.02	311	70628	51584	79621865
Parkinsonism	325.97	13.02	196	70743	16388	79657061
Tardive dyskinesia	311.55	13.02	163	70776	10408	79663041
Catatonia	283.98	13.02	144	70795	8612	79664837
Diabetes insipidus	281.12	13.02	122	70817	5115	79668334
Obsessive-compulsive disorder	269.78	13.02	123	70816	5804	79667645
Hallucination, auditory	258.20	13.02	184	70755	20509	79652940
Aggression	253.92	13.02	268	70671	50690	79622759
Salivary hypersecretion	251.18	13.02	157	70782	14067	79659382
Bipolar disorder	241.95	13.02	124	70815	7583	79665866
Pain	241.23	13.02	166	70773	703636	78969813
Granulocytopenia	234.79	13.02	139	70800	11292	79662157
Dysarthria	226.69	13.02	290	70649	67332	79606117
Irritability	224.10	13.02	227	70712	40917	79632532
Arthralgia	223.77	13.02	115	70824	571688	79101761
Hypernatraemia	219.31	13.02	145	70794	14306	79659143
Muscle rigidity	219.08	13.02	164	70775	19718	79653731
Overdose	216.87	13.02	495	70444	183711	79489738
Dyspnoea	211.76	13.02	272	70667	856753	78816696
Delirium	210.12	13.02	314	70625	84313	79589136
Confusional state	205.72	13.02	686	70253	317311	79356138
Psychomotor hyperactivity	194.65	13.02	143	70796	16706	79656743
Delusion	180.73	13.02	148	70791	20275	79653174
Hyperreflexia	180.20	13.02	105	70834	8280	79665169
Mental status changes	178.58	13.02	257	70682	66702	79606747
Antipsychotic drug level below therapeutic	173.03	13.02	58	70881	1180	79672269
Myoclonus	168.05	13.02	162	70777	27498	79645951
Jaundice cholestatic	161.07	13.02	109	70830	11175	79662274
Disorientation	160.21	13.02	236	70703	62540	79610909
Somnolence	155.69	13.02	517	70422	238464	79434985
Neurotoxicity	154.85	13.02	167	70772	32351	79641098
Abnormal behaviour	154.40	13.02	176	70763	36245	79637204
Intentional overdose	150.08	13.02	307	70632	105653	79567796
Drug level increased	148.79	13.02	180	70759	39471	79633978
Infusion related reaction	148.27	13.02	16	70923	230221	79443228
Rheumatoid arthritis	146.47	13.02	10	70929	208460	79464989
Dystonia	144.68	13.02	133	70806	21266	79652183
Euphoric mood	143.30	13.02	88	70851	7638	79665811
Dyskinesia	134.50	13.02	182	70757	44591	79628858
Joint swelling	133.72	13.02	45	70894	288601	79384848
Polyuria	133.25	13.02	109	70830	14905	79658544
Schizoaffective disorder	128.27	13.02	54	70885	2098	79671351
Febrile neutropenia	128.06	13.02	25	70914	230974	79442475
Hypothyroidism	128	13.02	193	70746	52199	79621250
Anaemia	127.30	13.02	125	70814	444890	79228559
Disturbance in attention	123.91	13.02	187	70752	50614	79622835
Pleurothotonus	120.16	13.02	54	70885	2462	79670987
Synovitis	119.81	13.02	3	70936	150731	79522718
Hypersensitivity	119.53	13.02	42	70897	262197	79411252
Neutrophil count increased	119.46	13.02	139	70800	29257	79644192
Pruritus	118.56	13.02	106	70833	394542	79278907
Arthropathy	117.43	13.02	11	70928	177100	79496349
Delusion of grandeur	116.69	13.02	45	70894	1387	79672062
Cough	115.69	13.02	94	70845	366695	79306754
Weight increased	114.91	13.02	520	70419	276866	79396583
Treatment noncompliance	114.36	13.02	183	70756	52085	79621364
Swelling	112.90	13.02	27	70912	216684	79456765
Polydipsia	111.83	13.02	71	70868	6534	79666915
Peripheral swelling	111.70	13.02	50	70889	269567	79403882
Nasopharyngitis	110.11	13.02	44	70895	253837	79419612
Brugada syndrome	108.41	13.02	41	70898	1197	79672252
Rash	108.21	13.02	220	70719	578138	79095311
Pain in extremity	108.18	13.02	99	70840	364439	79309010
Depression	107.25	13.02	429	70510	216361	79457088
Paranoia	107.22	13.02	108	70831	19324	79654125
Depressed level of consciousness	106.23	13.02	253	70686	96399	79577050
Nephropathy	102.12	13.02	78	70861	9660	79663789
Bruxism	101.58	13.02	56	70883	3970	79669479
Malignant neoplasm progression	100.14	13.02	5	70934	135985	79537464
Mental disorder	99.78	13.02	131	70808	31171	79642278
Restlessness	97.92	13.02	160	70779	46332	79627117
Back pain	97.08	13.02	77	70862	304103	79369346
Electrocardiogram QT prolonged	96.54	13.02	234	70705	90152	79583297
Bipolar I disorder	96.31	13.02	44	70895	2085	79671364
Intentional self-injury	96.18	13.02	131	70808	32288	79641161
Systemic lupus erythematosus	94.11	13.02	3	70936	121146	79552303
Sinusitis	93.12	13.02	29	70910	195472	79477977
Myocarditis	92.06	13.02	105	70834	21628	79651821
Apathy	90.34	13.02	82	70857	12895	79660554
Cognitive disorder	90.13	13.02	195	70744	69731	79603718
Stomatitis	90.01	13.02	12	70927	146745	79526704
Leukocytosis	89.43	13.02	148	70791	43307	79630142
Clonus	88.03	13.02	62	70877	6778	79666671
White blood cell count increased	87.07	13.02	200	70739	74433	79599016
Priapism	85.30	13.02	52	70887	4453	79668996
Grandiosity	84.02	13.02	28	70911	559	79672890
Cogwheel rigidity	83.59	13.02	45	70894	3043	79670406
Interstitial lung disease	83.35	13.02	4	70935	112596	79560853
Libido increased	83.18	13.02	39	70900	1962	79671487
Leukopenia	82.94	13.02	260	70679	116253	79557196
Blood creatine phosphokinase increased	82.56	13.02	182	70757	65908	79607541
Affect lability	82.04	13.02	73	70866	11186	79662263
Speech disorder	80.92	13.02	161	70778	54284	79619165
Oppositional defiant disorder	80.38	13.02	26	70913	471	79672978
Infection	79.90	13.02	59	70880	241653	79431796
Arthritis	79.25	13.02	6	70933	114874	79558575
Logorrhoea	79.12	13.02	49	70890	4316	79669133
Depressed mood	78.94	13.02	149	70790	48331	79625118
Fatigue	78.76	13.02	495	70444	929232	78744217
Parathyroid tumour benign	78.57	13.02	29	70910	790	79672659
Anxiety	78.13	13.02	431	70508	248081	79425368
Lethargy	77.93	13.02	202	70737	81090	79592359
Hypercalcaemia	77.89	13.02	130	70809	38300	79635149
Pressure of speech	77.18	13.02	32	70907	1196	79672253
Atrial fibrillation	76.89	13.02	40	70899	197846	79475603
Mutism	76.88	13.02	39	70900	2333	79671116
General physical health deterioration	76.68	13.02	79	70860	275159	79398290
Homicidal ideation	76.16	13.02	44	70895	3413	79670036
Renal cyst	76.05	13.02	79	70860	14653	79658796
Drug intolerance	75.64	13.02	74	70865	264045	79409404
Total lung capacity increased	75.11	13.02	38	70901	2260	79671189
Coordination abnormal	73.93	13.02	84	70855	17228	79656221
Hyperprolactinaemia	73.57	13.02	48	70891	4628	79668821
Choreoathetosis	72.76	13.02	33	70906	1537	79671912
Glossodynia	72.42	13.02	5	70934	103332	79570117
Death	71.65	13.02	261	70678	566253	79107196
Sopor	71.41	13.02	115	70824	32895	79640554
Contraindicated product administered	70.44	13.02	26	70913	157512	79515937
Wound	70.06	13.02	10	70929	116169	79557280
Headache	69.10	13.02	323	70616	653449	79020000
Enuresis	68.85	13.02	40	70899	3136	79670313
Affective disorder	68.84	13.02	58	70881	8261	79665188
Withdrawal syndrome	68.54	13.02	101	70838	26753	79646696
Intentional product use issue	68.18	13.02	25	70914	152087	79521362
Chronic kidney disease	67.16	13.02	168	70771	65986	79607463
Urticaria	66.83	13.02	41	70898	185160	79488289
Decreased eye contact	66.30	13.02	26	70913	839	79672610
Hyperparathyroidism primary	65.93	13.02	22	70917	441	79673008
Thinking abnormal	65.13	13.02	69	70870	13092	79660357
Drug level above therapeutic	64.44	13.02	57	70882	8666	79664783
Altered state of consciousness	64.41	13.02	129	70810	43693	79629756
Abdominal pain upper	63.74	13.02	63	70876	223756	79449693
Hostility	63.47	13.02	34	70905	2276	79671173
Aphasia	63.30	13.02	133	70806	46599	79626850
Asthma-chronic obstructive pulmonary disease overlap syndrome	63.10	13.02	38	70901	3183	79670266
Disease progression	62.22	13.02	44	70895	184318	79489131
Body tinea	61.60	13.02	31	70908	1823	79671626
Poisoning	61.57	13.02	93	70846	25179	79648270
Increased appetite	61.42	13.02	64	70875	11914	79661535
Drooling	61.05	13.02	47	70892	5887	79667562
Camptocormia	60.90	13.02	21	70918	467	79672982
Blister	60.05	13.02	16	70923	119460	79553989
Sepsis	59.74	13.02	92	70847	269336	79404113
Insomnia	59.73	13.02	398	70541	244772	79428677
Cholelithiasis	59.08	13.02	139	70800	52525	79620924
Alopecia	58.32	13.02	72	70867	231283	79442166
Schizoaffective disorder bipolar type	57.49	13.02	17	70922	225	79673224
Abdominal pain	56.41	13.02	169	70770	389400	79284049
Poor quality sleep	55.90	13.02	84	70855	22638	79650811
Somatic symptom disorder	55.12	13.02	32	70907	2505	79670944
Stupor	54.99	13.02	47	70892	6825	79666624
Dystonic tremor	54.73	13.02	16	70923	203	79673246
Disinhibition	54.41	13.02	32	70907	2566	79670883
Encephalopathy	54.16	13.02	157	70782	67240	79606209
Impaired healing	54.14	13.02	7	70932	87648	79585801
Cardiac failure congestive	53.53	13.02	30	70909	142372	79531077
Anger	53.42	13.02	71	70868	17091	79656358
Pneumonia	52.98	13.02	357	70582	659889	79013560
Asthma	52.92	13.02	27	70912	135068	79538381
Therapeutic product effect decreased	52.84	13.02	41	70898	163822	79509627
Blood sodium increased	51.56	13.02	39	70900	4759	79668690
Gastrointestinal haemorrhage	51.51	13.02	34	70905	147685	79525764
Psoriatic arthropathy	51.26	13.02	5	70934	77994	79595455
Diarrhoea	51.16	13.02	519	70420	879970	78793479
Septic shock	50.46	13.02	23	70916	122778	79550671
Bronchitis	49.86	13.02	27	70912	130617	79542832
Hepatotoxicity	49.61	13.02	128	70811	51224	79622225
Anticholinergic syndrome	49.44	13.02	34	70905	3577	79669872
Cerebellar syndrome	49.08	13.02	40	70899	5440	79668009
Abulia	49.05	13.02	22	70917	998	79672451
Distractibility	48.81	13.02	20	70919	725	79672724
Neurological symptom	48.79	13.02	49	70890	8734	79664715
Drug reaction with eosinophilia and systemic symptoms	47.21	13.02	145	70794	64099	79609350
Thrombocytopenia	46.88	13.02	104	70835	265155	79408294
Ascites	46.75	13.02	6	70933	75556	79597893
Memory impairment	46.56	13.02	210	70729	111524	79561925
Resting tremor	46.37	13.02	24	70915	1497	79671952
Cerebellar atrophy	46.33	13.02	22	70917	1139	79672310
Abdominal discomfort	46.23	13.02	96	70843	250631	79422818
Major depression	46.07	13.02	48	70891	8932	79664517
Electrocardiogram T wave abnormal	46.07	13.02	33	70906	3705	79669744
Oxygen saturation decreased	45.95	13.02	29	70910	129018	79544431
Musculoskeletal pain	45.56	13.02	17	70922	102337	79571112
Fibromyalgia	45.41	13.02	3	70936	64337	79609112
Electrocardiogram QRS complex prolonged	45.30	13.02	52	70887	10781	79662668
Inhibitory drug interaction	45.23	13.02	35	70904	4418	79669031
Seizure	45.03	13.02	305	70634	188529	79484920
Trismus	44.99	13.02	38	70901	5429	79668020
Mental impairment	44.88	13.02	69	70870	18967	79654482
Injection site erythema	44.29	13.02	8	70931	78189	79595260
Product tampering	44.19	13.02	16	70923	412	79673037
Gastrointestinal disorder	44.15	13.02	27	70912	122178	79551271
Renal oncocytoma	43.99	13.02	11	70928	73	79673376
Action tremor	43.48	13.02	16	70923	432	79673017
Osteoarthritis	43.29	13.02	12	70927	87297	79586152
Bradykinesia	43.09	13.02	44	70895	7999	79665450
Cardio-respiratory arrest	43.03	13.02	201	70738	108309	79565140
Metabolic syndrome	42.80	13.02	28	70911	2712	79670737
Malaise	42.77	13.02	258	70681	489611	79183838
Failure to suspend medication	42.60	13.02	16	70923	458	79672991
Productive cough	42.22	13.02	13	70926	88318	79585131
Pericarditis	42.09	13.02	20	70919	104216	79569233
Adulterated product	41.99	13.02	14	70925	280	79673169
Blunted affect	41.86	13.02	16	70923	481	79672968
Blood prolactin increased	41.77	13.02	32	70907	3979	79669470
Postural tremor	41.71	13.02	18	70921	744	79672705
Infection susceptibility increased	41.66	13.02	31	70908	3690	79669759
Depressive symptom	41.63	13.02	39	70900	6384	79667065
Claustrophobia	41.51	13.02	21	70918	1249	79672200
Electrocardiogram T wave inversion	41.48	13.02	36	70903	5336	79668113
Muscle twitching	41.41	13.02	77	70862	24687	79648762
Mood swings	41.29	13.02	68	70871	19812	79653637
Personality disorder	41.15	13.02	38	70901	6108	79667341
Thrombosis	40.88	13.02	12	70927	84088	79589361
Myocardial infarction	40.67	13.02	63	70876	184066	79489383
Pancytopenia	40.28	13.02	53	70886	165692	79507757
Weight decreased	40.13	13.02	171	70768	355027	79318422
Soft tissue injury	40.12	13.02	23	70916	1758	79671691
Visuospatial deficit	39.78	13.02	9	70930	36	79673413
Discomfort	39.78	13.02	32	70907	125585	79547864
Pneumonitis	39.74	13.02	4	70935	60856	79612593
Drug hypersensitivity	39.52	13.02	135	70804	298781	79374668
Haemodialysis	38.89	13.02	63	70876	18105	79655344
Hallucination	38.64	13.02	165	70774	85580	79587869
Psychiatric symptom	38.62	13.02	39	70900	6996	79666453
Decreased appetite	38.59	13.02	165	70774	342253	79331196
Oculogyric crisis	38.55	13.02	27	70912	2925	79670524
Behaviour disorder	38.38	13.02	37	70902	6276	79667173
Chest pain	38.34	13.02	126	70813	282178	79391271
Erythema	38.27	13.02	89	70850	223201	79450248
Drug withdrawal syndrome	38.25	13.02	91	70848	34627	79638822
Persecutory delusion	38.11	13.02	33	70906	4876	79668573
Psychiatric decompensation	37.77	13.02	30	70909	3933	79669516
Glucose tolerance impaired	37.57	13.02	41	70898	8043	79665406
Electroencephalogram abnormal	37.16	13.02	34	70905	5400	79668049
Hypothermia	37.13	13.02	70	70869	22676	79650773
Anaphylactic reaction	37.12	13.02	14	70925	83729	79589720
Hyperthyroidism	37.07	13.02	69	70870	22140	79651309
Feelings of worthlessness	36.78	13.02	15	70924	537	79672912
Electroconvulsive therapy	36.64	13.02	10	70929	97	79673352
Goitre	36.61	13.02	34	70905	5505	79667944
Lung disorder	36.50	13.02	13	70926	80544	79592905
Flight of ideas	36.45	13.02	17	70922	845	79672604
Suspected suicide	36.42	13.02	46	70893	10530	79662919
Sleep-related eating disorder	36.26	13.02	16	70923	698	79672751
Cardiac failure	36.13	13.02	51	70888	154791	79518658
Hypertonia	35.93	13.02	38	70901	7194	79666255
Asterixis	35.91	13.02	25	70914	2682	79670767
Self-injurious ideation	35.66	13.02	28	70911	3610	79669839
Galactorrhoea	35.60	13.02	28	70911	3618	79669831
Nasal polyps	35.52	13.02	38	70901	7289	79666160
Hyperthermia	35.19	13.02	60	70879	17977	79655472
Respiratory arrest	35.17	13.02	122	70817	57428	79616021
Melaena	34.98	13.02	6	70933	60884	79612565
Muscle contractions involuntary	34.81	13.02	28	70911	3737	79669712
Social avoidant behaviour	34.65	13.02	31	70908	4783	79668666
Epistaxis	34.57	13.02	29	70910	111486	79561963
Haemorrhage	34.52	13.02	19	70920	91099	79582350
Impulsive behaviour	34.36	13.02	25	70914	2875	79670574
Mood altered	34.34	13.02	59	70880	17788	79655661
Acute psychosis	34.29	13.02	29	70910	4151	79669298
Blood bilirubin increased	34.25	13.02	133	70806	66099	79607350
Post-traumatic neck syndrome	34.18	13.02	22	70917	2072	79671377
Blood thyroid stimulating hormone decreased	33.81	13.02	33	70906	5683	79667766
Blood pressure fluctuation	33.72	13.02	9	70930	67136	79606313
Plasma cell myeloma	33.50	13.02	4	70935	53255	79620194
Hyperkinesia	33.42	13.02	24	70915	2705	79670744
Feeling guilty	33.27	13.02	16	70923	852	79672597
Sarcoidosis	33.17	13.02	39	70900	8296	79665153
Electrocardiogram abnormal	33.09	13.02	56	70883	16681	79656768
Bradyphrenia	33.08	13.02	44	70895	10596	79662853
International normalised ratio increased	33.08	13.02	17	70922	84704	79588745
Lower respiratory tract infection	32.77	13.02	40	70899	129180	79544269
Nodal rhythm	32.62	13.02	25	70914	3110	79670339
Therapeutic product effect variable	32.53	13.02	21	70918	1988	79671461
Dysphemia	32.40	13.02	26	70913	3458	79669991
Injection site pain	32.08	13.02	41	70898	129797	79543652
Speech sound disorder	32.00	13.02	8	70931	53	79673396
Gait disturbance	31.85	13.02	303	70636	207203	79466246
Mobility decreased	31.85	13.02	37	70902	122138	79551311
Pleural effusion	31.79	13.02	50	70889	145212	79528237
Dyspnoea exertional	31.78	13.02	19	70920	87054	79586395
Rhinalgia	31.73	13.02	22	70917	2345	79671104
Autonomic nervous system imbalance	31.72	13.02	29	70910	4601	79668848
Rhinorrhoea	31.64	13.02	14	70925	76060	79597389
Oncocytoma	31.14	13.02	7	70932	27	79673422
Echolalia	31.11	13.02	12	70927	370	79673079
Antipsychotic drug level decreased	30.81	13.02	17	70922	1207	79672242
Inflammation	30.80	13.02	23	70916	93730	79579719
Cerebrovascular accident	30.73	13.02	57	70882	155235	79518214
Agranulocytosis	30.66	13.02	99	70840	44931	79628518
Amenorrhoea	30.62	13.02	36	70903	7656	79665793
Restless legs syndrome	30.55	13.02	60	70879	20032	79653417
Sternal fracture	30.41	13.02	22	70917	2508	79670941
Papillary thyroid cancer	29.98	13.02	22	70917	2564	79670885
Influenza	29.92	13.02	43	70896	129563	79543886
Judgement impaired	29.85	13.02	17	70922	1283	79672166
Urinary incontinence	29.74	13.02	92	70847	40817	79632632
Neutrophilia	29.66	13.02	36	70903	7915	79665534
Product use issue	29.63	13.02	92	70847	209730	79463719
Haemoglobin decreased	29.56	13.02	100	70839	222019	79451430
Tachycardia	29.51	13.02	264	70675	177504	79495945
Blood creatinine increased	29.29	13.02	237	70702	154820	79518629
Acute myocardial infarction	29.27	13.02	16	70923	77020	79596429
Dysphoria	29.26	13.02	28	70911	4706	79668743
Convulsive threshold lowered	29.04	13.02	15	70924	932	79672517
Hyperhidrosis	28.86	13.02	232	70707	151260	79522189
Cardiac hypertrophy	28.79	13.02	18	70921	1612	79671837
Adams-Stokes syndrome	28.63	13.02	9	70930	148	79673301
Otospondylomegaepiphyseal dysplasia	28.60	13.02	7	70932	42	79673407
Hypokalaemia	28.39	13.02	53	70886	143987	79529462
Pyrexia	28.38	13.02	429	70510	678280	78995169
Bundle branch block right	28.25	13.02	42	70897	11209	79662240
Rebound psychosis	27.82	13.02	11	70928	363	79673086
Patient restraint	27.70	13.02	8	70931	97	79673352
Treatment failure	27.59	13.02	70	70869	170416	79503033
Lymphocyte count abnormal	27.57	13.02	17	70922	1486	79671963
Long QT syndrome	27.32	13.02	30	70909	5925	79667524
Tachyphrenia	27.11	13.02	19	70920	2061	79671388
Hallucination, visual	27.02	13.02	77	70862	32652	79640797
Bone pain	27.01	13.02	8	70931	55734	79617715
Upper respiratory tract infection	26.70	13.02	25	70914	91143	79582306
Upper gastrointestinal haemorrhage	26.30	13.02	3	70936	41377	79632072
Parkinsonian gait	26.18	13.02	14	70925	934	79672515
Wrong patient received product	26.09	13.02	26	70913	4592	79668857
Hereditary ataxia	25.95	13.02	6	70933	27	79673422
Paraesthesia	25.83	13.02	76	70863	176247	79497202
Skin ulcer	25.82	13.02	8	70931	54142	79619307
Acquired cystic kidney disease	25.73	13.02	7	70932	67	79673382
Hyporeflexia	25.73	13.02	23	70916	3545	79669904
Knee arthroplasty	25.43	13.02	4	70935	43244	79630205
Myelosuppression	25.41	13.02	3	70936	40293	79633156
Osteonecrosis of jaw	25.41	13.02	4	70935	43222	79630227
Acute kidney injury	25.13	13.02	622	70317	518782	79154667
Diabetic coma	25.13	13.02	15	70924	1236	79672213
Flat affect	25.11	13.02	18	70921	2023	79671426
Cerebral haemorrhage	24.97	13.02	10	70929	57663	79615786
Gaze palsy	24.96	13.02	21	70918	2984	79670465
Cystitis	24.77	13.02	8	70931	52724	79620725
Delusion of reference	24.68	13.02	8	70931	146	79673303
Substance abuse	24.60	13.02	38	70901	10488	79662961
Haematochezia	24.55	13.02	25	70914	87620	79585829
Defect conduction intraventricular	24.46	13.02	11	70928	502	79672947
Haematoma	24.37	13.02	8	70931	52187	79621262
Coronary artery disease	24.30	13.02	14	70925	65460	79607989
Injection site swelling	24.27	13.02	6	70933	47126	79626323
Nephropathy toxic	24.11	13.02	55	70884	20364	79653085
Ideas of reference	23.90	13.02	8	70931	162	79673287
Staphylococcal infection	23.81	13.02	11	70928	58284	79615165
Haemoptysis	23.77	13.02	10	70929	55989	79617460
Chest discomfort	23.66	13.02	55	70884	137989	79535460
Neuropathy peripheral	23.66	13.02	57	70882	141248	79532201
Coma	23.63	13.02	162	70777	100487	79572962
Rhabdomyolysis	23.63	13.02	165	70774	102966	79570483
Hyperammonaemic encephalopathy	23.53	13.02	25	70914	4757	79668692
Nystagmus	23.49	13.02	36	70903	9868	79663581
Sinus arrest	23.49	13.02	22	70917	3600	79669849
Muscle injury	23.47	13.02	7	70932	48554	79624895
Sluggishness	23.29	13.02	29	70910	6543	79666906
Antipsychotic drug level	23.21	13.02	5	70934	15	79673434
Balance disorder	23.14	13.02	159	70780	98698	79574751
Hyperammonaemia	23.11	13.02	38	70901	11055	79662394
Rhinitis allergic	22.87	13.02	40	70899	12229	79661220
Metabolic encephalopathy	22.76	13.02	34	70905	9113	79664336
Hyperkalaemia	22.62	13.02	42	70897	114356	79559093
Blood pressure systolic increased	22.57	13.02	16	70923	66970	79606479
Antidepressant drug level increased	22.54	13.02	10	70929	442	79673007
Thyroiditis	22.53	13.02	24	70915	4581	79668868
Sexual dysfunction	22.46	13.02	31	70908	7732	79665717
Angina pectoris	22.34	13.02	9	70930	51723	79621726
Muscle spasms	22.34	13.02	80	70859	174650	79498799
Hypoxia	22.15	13.02	36	70903	103207	79570242
Oromandibular dystonia	22.08	13.02	13	70926	1045	79672404
Obesity	21.93	13.02	75	70864	35050	79638399
Dry skin	21.92	13.02	17	70922	67978	79605471
Drug level decreased	21.88	13.02	43	70896	14359	79659090
Hallucination, olfactory	21.81	13.02	10	70929	478	79672971
Eosinophilia	21.78	13.02	89	70850	45256	79628193
Negativism	21.76	13.02	12	70927	851	79672598
Status epilepticus	21.74	13.02	60	70879	24981	79648468
Colitis	21.59	13.02	20	70919	73287	79600162
Ileus paralytic	21.47	13.02	34	70905	9586	79663863
Clear cell renal cell carcinoma	21.39	13.02	18	70921	2558	79670891
Maternal exposure during pregnancy	21.37	13.02	57	70882	136481	79536968
High-grade B-cell lymphoma	21.23	13.02	7	70932	135	79673314
Thought blocking	21.20	13.02	8	70931	232	79673217
Consciousness fluctuating	21.15	13.02	16	70923	1953	79671496
Rectal haemorrhage	21.10	13.02	22	70917	76278	79597171
CSWS syndrome	21.03	13.02	5	70934	26	79673423
Hepatocellular injury	21.02	13.02	8	70931	47585	79625864
Localised infection	20.94	13.02	4	70935	37571	79635878
Muscle contracture	20.93	13.02	17	70922	2300	79671149
Ear infection	20.67	13.02	3	70936	34429	79639020
Fluid retention	20.61	13.02	19	70920	69790	79603659
Unmasking of previously unidentified disease	20.53	13.02	16	70923	2041	79671408
Lactate pyruvate ratio increased	20.32	13.02	6	70933	79	79673370
Mydriasis	20.25	13.02	47	70892	17596	79655853
Cardiac murmur	20.23	13.02	44	70895	15780	79657669
Cerebral atrophy	20.07	13.02	30	70909	8045	79665404
Oropharyngeal pain	20.02	13.02	42	70897	109311	79564138
Diverticulitis	19.83	13.02	8	70931	45928	79627521
Thyrotoxic crisis	19.76	13.02	13	70926	1271	79672178
Injection site bruising	19.65	13.02	6	70933	40996	79632453
Off label use	19.53	13.02	637	70302	906578	78766871
Irritable bowel syndrome	19.52	13.02	16	70923	62225	79611224
Drug abuse	19.50	13.02	226	70713	162465	79510984
Brain injury	19.49	13.02	36	70903	11481	79661968
Ill-defined disorder	19.37	13.02	18	70921	65857	79607592
Full blood count abnormal	19.26	13.02	6	70933	40468	79632981
Conduction disorder	19.04	13.02	19	70920	3360	79670089
Staring	18.97	13.02	17	70922	2628	79670821
Eosinophil count decreased	18.96	13.02	19	70920	3377	79670072
Myoclonic epilepsy	18.96	13.02	15	70924	1955	79671494
Blood triglycerides increased	18.85	13.02	51	70888	20989	79652460
Basal cell carcinoma	18.78	13.02	5	70934	37370	79636079
Colitis ulcerative	18.73	13.02	4	70935	34738	79638711
Sinus bradycardia	18.56	13.02	57	70882	25190	79648259
Blood thyroid stimulating hormone increased	18.55	13.02	32	70907	9676	79663773
Nausea	18.55	13.02	681	70258	956515	78716934
Fungal infection	18.46	13.02	7	70932	41741	79631708
Torticollis	18.44	13.02	16	70923	2371	79671078
Sleep disorder	18.42	13.02	135	70804	85542	79587907
Histrionic personality disorder	18.37	13.02	5	70934	48	79673401
Differential white blood cell count abnormal	18.26	13.02	15	70924	2062	79671387
Osteonecrosis	18.00	13.02	3	70936	31092	79642357
Hypophagia	17.95	13.02	84	70855	45283	79628166
Femur fracture	17.92	13.02	6	70933	38646	79634803
Throat irritation	17.89	13.02	7	70932	40939	79632510
Secondary tic	17.88	13.02	4	70935	15	79673434
Intention tremor	17.79	13.02	10	70929	736	79672713
Sexually inappropriate behaviour	17.78	13.02	9	70930	536	79672913
Angioedema	17.77	13.02	25	70914	76010	79597439
Hallucinations, mixed	17.68	13.02	26	70913	6873	79666576
Decreased interest	17.62	13.02	19	70920	3678	79669771
Prostate cancer	17.59	13.02	4	70935	33264	79640185
Blood citric acid increased	17.43	13.02	5	70934	59	79673390
Social anxiety disorder	17.38	13.02	9	70930	562	79672887
Bacteraemia	17.25	13.02	4	70935	32820	79640629
Pulse abnormal	17.20	13.02	18	70921	3366	79670083
COVID-19	17.11	13.02	77	70862	157597	79515852
Myalgia	17.10	13.02	96	70843	185545	79487904
Body mass index increased	17.08	13.02	14	70925	1919	79671530
Merycism	17.00	13.02	7	70932	257	79673192
Incoherent	16.91	13.02	27	70912	7665	79665784
Sinus node dysfunction	16.88	13.02	27	70912	7674	79665775
Movement disorder	16.84	13.02	58	70881	27201	79646248
Night sweats	16.83	13.02	13	70926	52082	79621367
Haematuria	16.73	13.02	22	70917	68814	79604635
Dry eye	16.66	13.02	6	70933	36925	79636524
Bradycardia	16.55	13.02	189	70750	135368	79538081
Gestational diabetes	16.54	13.02	24	70915	6269	79667180
Gambling disorder	16.50	13.02	14	70925	2012	79671437
Activation syndrome	16.48	13.02	7	70932	278	79673171
Concussion	16.46	13.02	30	70909	9473	79663976
Bipolar II disorder	16.34	13.02	8	70931	443	79673006
Nephrolithiasis	16.34	13.02	14	70925	53277	79620172
Limbic encephalitis	16.31	13.02	10	70929	865	79672584
Sleep apnoea syndrome	16.28	13.02	70	70869	36408	79637041
Atrioventricular block first degree	16.27	13.02	35	70904	12456	79660993
Oedema peripheral	16.13	13.02	145	70794	252143	79421306
Mouth ulceration	16.07	13.02	7	70932	38387	79635062
Antidepressant drug level above therapeutic	15.95	13.02	9	70930	667	79672782
Metabolic disorder	15.94	13.02	29	70910	9141	79664308
Dyslipidaemia	15.62	13.02	33	70906	11600	79661849
Pain in jaw	15.57	13.02	11	70928	46140	79627309
Blood pressure increased	15.55	13.02	117	70822	211243	79462206
Autoimmune thyroiditis	15.52	13.02	19	70920	4214	79669235
Injection site haemorrhage	15.46	13.02	3	70936	27867	79645582
Hepatic failure	15.46	13.02	19	70920	61193	79612256
Tic	15.39	13.02	16	70923	2970	79670479
Neoplasm progression	15.34	13.02	14	70925	51668	79621781
Essential tremor	15.31	13.02	12	70927	1543	79671906
Urine output increased	15.20	13.02	14	70925	2242	79671207
Cerebral amyloid angiopathy	15.16	13.02	7	70932	340	79673109
Cerebellar ataxia	15.09	13.02	13	70926	1908	79671541
Refusal of treatment by patient	15.09	13.02	28	70911	8963	79664486
Oscillopsia	15.06	13.02	6	70933	202	79673247
Generalised tonic-clonic seizure	15.02	13.02	78	70861	43832	79629617
Impaired work ability	14.99	13.02	45	70894	19636	79653813
Water intoxication	14.82	13.02	9	70930	765	79672684
Cyclothymic disorder	14.79	13.02	6	70933	212	79673237
Eye movement disorder	14.78	13.02	26	70913	7985	79665464
Device related infection	14.75	13.02	6	70933	34288	79639161
Thyroid function test abnormal	14.75	13.02	16	70923	3118	79670331
Parasomnia	14.70	13.02	8	70931	553	79672896
Platelet count decreased	14.69	13.02	107	70832	194557	79478892
Glomerulonephritis minimal lesion	14.68	13.02	9	70930	778	79672671
Flatulence	14.66	13.02	10	70929	42714	79630735
Clostridium difficile infection	14.64	13.02	10	70929	42675	79630774
Diabetic hyperosmolar coma	14.58	13.02	9	70930	788	79672661
Human herpesvirus 6 infection reactivation	14.51	13.02	8	70931	567	79672882
Hypersexuality	14.49	13.02	12	70927	1668	79671781
Obstructive airways disorder	14.38	13.02	5	70934	31454	79641995
Pulmonary mass	14.37	13.02	4	70935	29030	79644419
Suicidal behaviour	14.28	13.02	16	70923	3231	79670218
Bursitis	14.28	13.02	7	70932	35837	79637612
Polyhydramnios	14.25	13.02	12	70927	1708	79671741
Apraxia	14.13	13.02	15	70924	2852	79670597
Hypovolaemia	14	13.02	41	70898	17650	79655799
Acute myeloid leukaemia	13.96	13.02	5	70934	30880	79642569
Toxic cardiomyopathy	13.95	13.02	7	70932	409	79673040
Dysphagia	13.90	13.02	168	70771	121968	79551481
Hip fracture	13.87	13.02	5	70934	30756	79642693
Dialysis	13.86	13.02	42	70897	18420	79655029
Accidental death	13.73	13.02	18	70921	4273	79669176
Fluid intake reduced	13.72	13.02	22	70917	6266	79667183
Toxic encephalopathy	13.71	13.02	31	70908	11409	79662040
Posture abnormal	13.61	13.02	17	70922	3849	79669600
Persistent depressive disorder	13.40	13.02	10	70929	1195	79672254
Ulcer	13.30	13.02	5	70934	29967	79643482
Waxy flexibility	13.28	13.02	6	70933	277	79673172
Amimia	13.19	13.02	4	70935	58	79673391
Stereotypy	13.18	13.02	9	70930	936	79672513
Tubulointerstitial nephritis	13.13	13.02	68	70871	38167	79635282
Psychotic disorder due to a general medical condition	13.12	13.02	6	70933	285	79673164
Psychotic symptom	13.10	13.02	14	70925	2683	79670766
Mucosal dryness	13.09	13.02	16	70923	3543	79669906
Small intestinal obstruction	13.05	13.02	4	70935	27268	79646181
Impaired self-care	13.05	13.02	14	70925	2693	79670756
Candida infection	13.04	13.02	9	70930	38205	79635244

FDA Adverse Event Reporting System (Pediatric)

None

Pharmacologic Action:

Source	Code	Description
ATC	N05AN01	NERVOUS SYSTEM PSYCHOLEPTICS ANTIPSYCHOTICS Lithium
CHEBI has role	CHEBI:35469	antidepressants
MeSH PA	D000928	Antidepressive Agents
MeSH PA	D018692	Antimanic Agents
MeSH PA	D002491	Central Nervous System Agents
MeSH PA	D002492	Central Nervous System Depressants
MeSH PA	D004791	Enzyme Inhibitors
MeSH PA	D011619	Psychotropic Drugs
MeSH PA	D014149	Tranquilizing Agents

Drug Use | Suggest Off label Use Form| |View source of the data|

Disease	Relation	SNOMED_ID	DOID
Bipolar disorder	indication	13746004	DOID:3312
Bipolar disorder in remission	indication	85248005
Bipolar affective disorder, current episode manic	indication	191618007
Vascular headache	off-label use	128187005
Bipolar affective disorder, current episode depression	off-label use	191627008	DOID:3312
Cluster Headache Prevention	off-label use
Rapid Cycling Bipolar Affective Disorder	off-label use
Psoriasis	contraindication	9014002	DOID:8893
Diabetes insipidus	contraindication	15771004	DOID:9409
Polyuria	contraindication	28442001
Hypothyroidism	contraindication	40930008	DOID:1459
Conduction disorder of the heart	contraindication	44808001
Chronic heart failure	contraindication	48447003
Acute infectious disease	contraindication	63171007
Hyponatremia	contraindication	89627008
Kidney disease	contraindication	90708001	DOID:557
Organic mental disorder	contraindication	111479008
Plaque psoriasis	contraindication	200965009
Pregnancy, function	contraindication	289908002
Breastfeeding (mother)	contraindication	413712001
Severe dehydration	contraindication	450316000
Lithium Toxicity	contraindication

🐶 Veterinary Drug Use

None

🐶 Veterinary products

None

Acid dissociation constants calculated using MoKa v3.0.0

None

Orange Book patent data (new drug applications)

None

Orange Book exclusivity data (new drug applications)

None

Bioactivity Summary:

Target	Class	Pharos	UniProt	Action	Type	Activity value (-log[M])	Mechanism action	Bioact source	MoA source
Glycogen synthase kinase-3	Kinase	P49840 P49841	GSK3A_HUMAN GSK3B_HUMAN	INHIBITOR				CHEMBL	CHEMBL
Inositol-1(or 4)-monophosphatase 1	Enzyme	P29218	IMPA1_HUMAN	INHIBITOR				CHEMBL	CHEMBL

External reference:

ID	Source
D04749	KEGG_DRUG
4018009	VUID
N0000179333	NUI
4018008	VANDF
4018009	VANDF
4019803	VANDF
CHEBI:64735	CHEBI
CHEBI:30145	CHEBI
CHEMBL1201170	ChEMBL_ID
CHEMBL2103738	ChEMBL_ID
CHEMBL1200826	ChEMBL_ID
C070669	MESH_SUPPLEMENTAL_RECORD_UI
DB14507	DRUGBANK_ID
5Z6E9K79YV	UNII
DB14509	DRUGBANK_ID
203056	RXNORM
1994	MMSL
2001	MMSL
4987	MMSL
d00061	MMSL
001532	NDDF
001534	NDDF
17805003	SNOMEDCT_US
321719003	SNOMEDCT_US
387098001	SNOMEDCT_US
85899009	SNOMEDCT_US
C0125997	UMLSCUI
D016651	MESH_DESCRIPTOR_UI
C0023870	UMLSCUI
CHEMBL2146126	ChEMBL_ID
13520	PUBCHEM_CID
6080-58-6	SECONDARY_CAS_RN
7439-93-2	SECONDARY_CAS_RN
3028194	PUBCHEM_CID
D008094	MESH_DESCRIPTOR_UI
9FN79X2M3F	UNII

Pharmaceutical products:

Product	Category	Ingredients	NDC	Form	Quantity	Route	Marketing	Label
Lithium	HUMAN PRESCRIPTION DRUG LABEL	1	0054-3527	SOLUTION	8 meq	ORAL	NDA	26 sections
Lithium	HUMAN PRESCRIPTION DRUG LABEL	1	0054-3527	SOLUTION	8 meq	ORAL	NDA	26 sections
Lithium	HUMAN PRESCRIPTION DRUG LABEL	1	0054-3527	SOLUTION	8 meq	ORAL	NDA	26 sections
Lithium	HUMAN PRESCRIPTION DRUG LABEL	1	68094-757	SOLUTION	8 meq	ORAL	NDA	27 sections
Lithium	HUMAN PRESCRIPTION DRUG LABEL	1	72888-172	SOLUTION	8 meq	ORAL	ANDA	26 sections