butoconazole 🐶 Veterinary Use | Indications/Contra | FAERs-F | FAERs-M | Orange Bk | BioActivity |

Stem definition	Drug id	CAS RN
systemic antifungal agents, miconazole derivatives	450	64872-77-1

Description:

Molecule

Description

Molfile Inchi Smiles

Synonyms:

butoconazole
butaconazole
butoconazole nitrate
butaconazole nitrate
femstat

Molecular weight: 411.77
Formula: C19H17Cl3N2S
CLOGP: 6.87
LIPINSKI: 1
HAC: 2
HDO: 0
TPSA: 17.82
ALOGS: -5.70
ROTB: 7

Status: OFP

Legend:
OFP - off patent
OFM - off market
ONP - on patent

Drug dosage:

Dose	Unit	Route
0.10	g	V

ADMET properties:

None

Approvals:

Date	Agency	Company	Orphan
Dec. 21, 1995	FDA	BAYER

FDA Adverse Event Reporting System (Female)

None

FDA Adverse Event Reporting System (Male)

None

FDA Adverse Event Reporting System (Geriatric)

None

FDA Adverse Event Reporting System (Pediatric)

None

Pharmacologic Action:

Source	Code	Description
ATC	G01AF15	GENITO URINARY SYSTEM AND SEX HORMONES GYNECOLOGICAL ANTIINFECTIVES AND ANTISEPTICS ANTIINFECTIVES AND ANTISEPTICS, EXCL. COMBINATIONS WITH CORTICOSTEROIDS Imidazole derivatives
FDA CS	M0002083	Azoles
FDA EPC	N0000175487	Azole Antifungal
MeSH PA	D000890	Anti-Infective Agents
MeSH PA	D000935	Antifungal Agents

Drug Use | Suggest Off label Use Form| |View source of the data|

Disease	Relation	SNOMED_ID	DOID
Candidal vulvovaginitis	indication	72605008	DOID:2272

🐶 Veterinary Drug Use

None

🐶 Veterinary products

None

Acid dissociation constants calculated using MoKa v3.0.0

Dissociation level	Dissociation constant	Type (acidic/basic)
pKa1	6.45	Basic

Orange Book patent data (new drug applications)

None

Orange Book exclusivity data (new drug applications)

None

Bioactivity Summary:

Target	Class	Pharos	UniProt	Action	Type	Activity value (-log[M])	Mechanism action	Bioact source	MoA source
Lanosterol 14-alpha demethylase	Enzyme		CP51_CANAL	INHIBITOR				CHEMBL	CHEMBL

External reference:

ID	Source
4019649	VUID
N0000147742	NUI
D00880	KEGG_DRUG
19884	RXNORM
C0054259	UMLSCUI
CHEBI:3240	CHEBI
CHEMBL1295	ChEMBL_ID
DB00639	DRUGBANK_ID
C017125	MESH_SUPPLEMENTAL_RECORD_UI
47472	PUBCHEM_CID
4496	INN_ID
0Q771797PH	UNII
4314	MMSL
9794	MMSL
372878005	SNOMEDCT_US
84844007	SNOMEDCT_US
85433002	SNOMEDCT_US
CHEMBL1200398	ChEMBL_ID
4018431	VANDF
4019649	VANDF
64872-76-0	SECONDARY_CAS_RN
002928	NDDF
004962	NDDF

Pharmaceutical products:

Product	Category	Ingredients	NDC	Form	Quantity	Route	Marketing	Label
gynazole 1	HUMAN PRESCRIPTION DRUG LABEL	1	45802-396	CREAM	100 mg	VAGINAL	ANDA	19 sections
gynazole 1	HUMAN PRESCRIPTION DRUG LABEL	1	45802-396	CREAM	100 mg	VAGINAL	ANDA	19 sections