racepinefrine 🐶 Veterinary Use | Indications/Contra | FAERs-F | FAERs-M | Orange Bk | BioActivity |

Stem definition	Drug id	CAS RN
sympathomimetic, phenethyl derivatives	4508	329-65-7

Description:

Molecule

Description

Molfile Inchi Smiles

Synonyms:

racepinephrine
epirenamine
racepinefrine
racepinephrine hydrochloride
racepinephrine HCl

A racemic mixture of d-epinephrine and l-epinephrine.

Molecular weight: 183.21
Formula: C9H13NO3
CLOGP: -0.68
LIPINSKI: 0
HAC: 4
HDO: 4
TPSA: 72.72
ALOGS: -0.99
ROTB: 3

Drug dosage:

None

ADMET properties:

None

Approvals:

Date	Agency	Company	Orphan
None	FDA

FDA Adverse Event Reporting System (Female)

None

FDA Adverse Event Reporting System (Male)

None

FDA Adverse Event Reporting System (Geriatric)

None

FDA Adverse Event Reporting System (Pediatric)

None

Pharmacologic Action:

Source	Code	Description
CHEBI has role	CHEBI:77746	Homo sapiens metabolite
MeSH PA	D018663	Adrenergic Agents
MeSH PA	D000322	Adrenergic Agonists
MeSH PA	D000316	Adrenergic alpha-Agonists
MeSH PA	D000318	Adrenergic beta-Agonists
MeSH PA	D018927	Anti-Asthmatic Agents
MeSH PA	D001993	Bronchodilator Agents
MeSH PA	D002317	Cardiovascular Agents
MeSH PA	D009184	Mydriatics
MeSH PA	D018377	Neurotransmitter Agents
MeSH PA	D018373	Peripheral Nervous System Agents
MeSH PA	D019141	Respiratory System Agents
MeSH PA	D013566	Sympathomimetics
MeSH PA	D014662	Vasoconstrictor Agents

Drug Use | Suggest Off label Use Form| |View source of the data|

Disease	Relation	SNOMED_ID	DOID
Hyperthyroidism	contraindication	34486009	DOID:7998
Hypertensive disorder	contraindication	38341003	DOID:10763
Cerebral arteriosclerosis	contraindication	65312002
Diabetes mellitus	contraindication	73211009	DOID:9351
Benign prostatic hyperplasia	contraindication	266569009
Angle-closure glaucoma	contraindication	392291006	DOID:13550
Peripheral vascular disease	contraindication	400047006
Disorder of coronary artery	contraindication	414024009

🐶 Veterinary Drug Use

None

🐶 Veterinary products

None

Acid dissociation constants calculated using MoKa v3.0.0

Dissociation level	Dissociation constant	Type (acidic/basic)
pKa1	9.97	acidic
pKa2	12.82	acidic
pKa3	13.64	acidic
pKa4	8.71	Basic

Orange Book patent data (new drug applications)

None

Orange Book exclusivity data (new drug applications)

None

Bioactivity Summary:

Target	Class	Pharos	UniProt	Action	Type	Activity value (-log[M])	Mechanism action	Bioact source	MoA source
Alpha-1A adrenergic receptor	GPCR	P35348	ADA1A_HUMAN	AGONIST	Ki	5		IUPHAR
Alpha-1D adrenergic receptor	GPCR	P25100	ADA1D_HUMAN	AGONIST	Ki	6		IUPHAR
Alpha-1B adrenergic receptor	GPCR	P35368	ADA1B_HUMAN	AGONIST	Ki	5.10		IUPHAR

External reference:

ID	Source
D05688	KEGG_DRUG
4023040	VUID
N0000189415	NUI
329-63-5	SECONDARY_CAS_RN
4019263	VANDF
4023040	VANDF
CHEBI:33568	CHEBI
CHEMBL1740	ChEMBL_ID
CHEMBL1255663	ChEMBL_ID
DB11124	DRUGBANK_ID
314610	RXNORM
5409	MMSL
d07647	MMSL
009897	NDDF
009898	NDDF
415227003	SNOMEDCT_US
D064705	MESH_DESCRIPTOR_UI
C0205758	UMLSCUI
4553	INN_ID
838	PUBCHEM_CID
GR0L9S3J0F	UNII

Pharmaceutical products:

Product	Category	Ingredients	NDC	Form	Quantity	Route	Marketing	Label
Asthmanefrin	HUMAN OTC DRUG LABEL	1	0487-2784	SOLUTION	11.25 mg	RESPIRATORY (INHALATION)	OTC monograph final	17 sections
S2	HUMAN OTC DRUG LABEL	1	0487-5901	SOLUTION	11.25 mg	RESPIRATORY (INHALATION)	OTC monograph final	17 sections
S2 RacepinephrineMULTI-DOSE	HUMAN OTC DRUG LABEL	1	0487-5910	SOLUTION	11.25 mg	RESPIRATORY (INHALATION)	Export only	17 sections
Epi-Mist	HUMAN OTC DRUG LABEL	1	15343-125	AEROSOL, SPRAY	0.59 mg	RESPIRATORY (INHALATION)	OTC monograph final	10 sections
Racepinephrine	HUMAN OTC DRUG LABEL	1	68071-5149	SOLUTION	11.25 mg	RESPIRATORY (INHALATION)	OTC monograph final	17 sections
Blue Gel Anesthetic	HUMAN OTC DRUG LABEL	3	80069-013	GEL	0.10 mg	TOPICAL	unapproved drug other	11 sections