racepinefrine Indications/Contra | FAERs-F | FAERs-M | Orange Bk | BioActivity |

Stem definitionDrug idCAS RN
sympathomimetic, phenethyl derivatives 4508 329-65-7

Description:

MoleculeDescription

Molfile Inchi Smiles

Synonyms:

  • racepinephrine
  • epirenamine
  • racepinefrine
  • racepinephrine hydrochloride
  • racepinephrine HCl
A racemic mixture of d-epinephrine and l-epinephrine.
  • Molecular weight: 183.21
  • Formula: C9H13NO3
  • CLOGP: -0.68
  • LIPINSKI: 0
  • HAC: 4
  • HDO: 4
  • TPSA: 72.72
  • ALOGS: -0.99
  • ROTB: 3

Drug dosage:

None

ADMET properties:

None

Approvals:

DateAgencyCompanyOrphan
None FDA

FDA Adverse Event Reporting System (Female)

None

FDA Adverse Event Reporting System (Male)

None

Pharmacologic Action:

SourceCodeDescription
MeSH PA D018663 Adrenergic Agents
MeSH PA D000322 Adrenergic Agonists
MeSH PA D000316 Adrenergic alpha-Agonists
MeSH PA D000318 Adrenergic beta-Agonists
MeSH PA D018927 Anti-Asthmatic Agents
MeSH PA D001993 Bronchodilator Agents
MeSH PA D002317 Cardiovascular Agents
MeSH PA D009184 Mydriatics
MeSH PA D018377 Neurotransmitter Agents
MeSH PA D018373 Peripheral Nervous System Agents
MeSH PA D019141 Respiratory System Agents
MeSH PA D013566 Sympathomimetics
MeSH PA D014662 Vasoconstrictor Agents

Drug Use (View source of the data)

DiseaseRelationSNOMED_IDDOID
Hyperthyroidism contraindication 34486009 DOID:7998
Hypertensive disorder contraindication 38341003 DOID:10763
Cerebral arteriosclerosis contraindication 65312002
Diabetes mellitus contraindication 73211009 DOID:9351
Benign prostatic hyperplasia contraindication 266569009
Angle-closure glaucoma contraindication 392291006 DOID:13550
Peripheral vascular disease contraindication 400047006
Disorder of coronary artery contraindication 414024009

Acid dissociation constants calculated using MoKa v3.0.0

Dissociation levelDissociation constantType (acidic/basic)
pKa1 9.97 acidic
pKa2 12.82 acidic
pKa3 13.64 acidic
pKa4 8.71 Basic

Orange Book patent data (new drug applications)

None

Orange Book exclusivity data (new drug applications)

None

Bioactivity Summary:

TargetClassPharosUniProtActionTypeActivity value
(-log[M])
Mechanism
action
Bioact sourceMoA source
Alpha-1D adrenergic receptor GPCR AGONIST Ki 6 IUPHAR
Alpha-1A adrenergic receptor GPCR AGONIST Ki 5 IUPHAR
Alpha-1B adrenergic receptor GPCR AGONIST Ki 5.10 IUPHAR

External reference:

IDSource
D05688 KEGG_DRUG
4023040 VUID
N0000189415 NUI
C0205758 UMLSCUI
336096P2WE UNII
329-63-5 SECONDARY_CAS_RN
CHEMBL1740 ChEMBL_ID
4553 INN_ID
DB11124 DRUGBANK_ID
CHEBI:33568 CHEBI
CHEMBL1255663 ChEMBL_ID
D064705 MESH_DESCRIPTOR_UI
838 PUBCHEM_CID
415227003 SNOMEDCT_US
4023040 VANDF
d07647 MMSL
66887 RXNORM
009897 NDDF

Pharmaceutical products:

ProductCategoryIngredientsNDCFormQuantityRouteMarketingLabel
Asthmanefrin HUMAN OTC DRUG LABEL 1 0487-2784 SOLUTION 11.25 mg RESPIRATORY (INHALATION) OTC monograph final 9 sections
S2 HUMAN OTC DRUG LABEL 1 0487-5901 SOLUTION 11.25 mg RESPIRATORY (INHALATION) OTC monograph final 10 sections
S2 Racepinephrine HUMAN OTC DRUG LABEL 1 0487-5910 SOLUTION 11.25 mg RESPIRATORY (INHALATION) Export only 10 sections
Epi-Mist HUMAN OTC DRUG LABEL 1 15343-125 AEROSOL, SPRAY 0.59 mg RESPIRATORY (INHALATION) OTC monograph final 10 sections
Racepinephrine HUMAN OTC DRUG LABEL 1 68071-5149 SOLUTION 11.25 mg RESPIRATORY (INHALATION) OTC monograph final 10 sections