hydrocortisone valerate 🐶 Veterinary Use | Indications/Contra | FAERs-F | FAERs-M | Orange Bk | BioActivity |
| Stem definition | Drug id | CAS RN |
|---|---|---|
| corticosteroids, except prednisolone derivatives | 4504 | 57524-89-7 |
Description:
| Molecule | Description |
|---|---|
|
Synonyms:
|
used in treatment of atopic dermatitis; RN given refers to 11beta-isomer
Legend: OFP - off patent OFM - off market ONP - on patent |
Drug dosage:
None
ADMET properties:
None
Approvals:
| Date | Agency | Company | Orphan |
|---|---|---|---|
| March 17, 1978 | FDA | RANBAXY |
FDA Adverse Event Reporting System (Female)
| MedDRA adverse event term | Likelihood ratio | Likelihood ratio threshold | Patients taking drug having adverse event | Patients taking drug not having adverse event | Patients not taking drug having adverse event | Patients not taking drug not having adverse event |
|---|---|---|---|---|---|---|
| Osteomyelitis | 48.47 | 35.01 | 14 | 363 | 22339 | 50582408 |
FDA Adverse Event Reporting System (Male)
None
FDA Adverse Event Reporting System (Geriatric)
| MedDRA adverse event term | Likelihood ratio | Likelihood ratio threshold | Patients taking drug having adverse event | Patients taking drug not having adverse event | Patients not taking drug having adverse event | Patients not taking drug not having adverse event |
|---|---|---|---|---|---|---|
| Periarthritis | 36.15 | 33.65 | 7 | 367 | 2560 | 64495798 |
| Psoriasis | 35.90 | 33.65 | 14 | 360 | 71689 | 64426669 |
FDA Adverse Event Reporting System (Pediatric)
None
Pharmacologic Action:
| Source | Code | Description |
|---|---|---|
| FDA MoA | N0000175450 | Corticosteroid Hormone Receptor Agonists |
| FDA EPC | N0000175576 | Corticosteroid |
| MeSH PA | D000893 | Anti-Inflammatory Agents |
| CHEBI has role | CHEBI:35472 | anti-inflammatory drugs |
| CHEBI has role | CHEBI:49167 | anti-asthmatic drugs |
| CHEBI has role | CHEBI:50857 | anti-allergic drugs |
| CHEBI has role | CHEBI:75771 | Mus musculus metabolites |
| CHEBI has role | CHEBI:77746 | Homo sapiens metabolite |
| CHEBI has role | CHEBI:88188 | allergenic drug |
Drug Use (View source of the data)
None
🐶 Veterinary Drug Use
None
🐶 Veterinary products
None
Acid dissociation constants calculated using MoKa v3.0.0
| Dissociation level | Dissociation constant | Type (acidic/basic) |
|---|---|---|
| pKa1 | 11.48 | acidic |
Orange Book patent data (new drug applications)
None
Orange Book exclusivity data (new drug applications)
None
Bioactivity Summary:
| Target | Class | Pharos | UniProt | Action | Type | Activity value (-log[M]) | Mechanism action | Bioact source | MoA source |
|---|---|---|---|---|---|---|---|---|---|
| Glucocorticoid receptor | Nuclear hormone receptor | AGONIST | CHEMBL | CHEMBL |
External reference:
| ID | Source |
|---|---|
| D02288 | KEGG_DRUG |
| 4017946 | VUID |
| N0000179155 | NUI |
| 4017941 | VANDF |
| 4017946 | VANDF |
| CHEBI:50865 | CHEBI |
| CHEBI:17650 | CHEBI |
| CHEMBL1200562 | ChEMBL_ID |
| C038363 | MESH_SUPPLEMENTAL_RECORD_UI |
| DB14544 | DRUGBANK_ID |
| 68717P8FUZ | UNII |
| 5282494 | PUBCHEM_CID |
| 5754 | PUBCHEM_CID |
| DB00741 | DRUGBANK_ID |
| 27199 | RXNORM |
| 11849 | MMSL |
| 2500 | MMSL |
| 4837 | MMSL |
| 4844 | MMSL |
| d00254 | MMSL |
| 002147 | NDDF |
| 002153 | NDDF |
| 16602005 | SNOMEDCT_US |
| 396458002 | SNOMEDCT_US |
| 51612003 | SNOMEDCT_US |
| C0063079 | UMLSCUI |
| C0020268 | UMLSCUI |
| 38 | INN_ID |
| D006854 | MESH_DESCRIPTOR_UI |
Pharmaceutical products:
| Product | Category | Ingredients | NDC | Form | Quantity | Route | Marketing | Label |
|---|---|---|---|---|---|---|---|---|
| Hydrocortisone Valerate | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0713-0560 | OINTMENT | 2 mg | TOPICAL | ANDA | 21 sections |
| Hydrocortisone Valerate | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0713-0560 | OINTMENT | 2 mg | TOPICAL | ANDA | 21 sections |
| Hydrocortisone Valerate | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0713-0668 | CREAM | 2 mg | TOPICAL | ANDA | 22 sections |
| Hydrocortisone Valerate | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0713-0669 | OINTMENT | 2 mg | TOPICAL | ANDA | 22 sections |
| HYDROCORTISONE VALERATE | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0713-0720 | CREAM | 2 mg | TOPICAL | ANDA | 18 sections |
| Hydrocortisone Valerate | HUMAN PRESCRIPTION DRUG LABEL | 1 | 21695-730 | CREAM | 2 mg | TOPICAL | ANDA | 22 sections |
| hydrocortisone valerate cream | HUMAN PRESCRIPTION DRUG LABEL | 1 | 21922-007 | CREAM | 2 mg | TOPICAL | ANDA | 18 sections |
| hydrocortisone valerate cream | HUMAN PRESCRIPTION DRUG LABEL | 1 | 21922-007 | CREAM | 2 mg | TOPICAL | ANDA | 18 sections |
| Hydrocortisone Valerate | HUMAN PRESCRIPTION DRUG LABEL | 1 | 45802-455 | CREAM | 2 mg | TOPICAL | ANDA | 22 sections |
| Hydrocortisone Valerate | HUMAN PRESCRIPTION DRUG LABEL | 1 | 50090-2525 | CREAM | 2 mg | TOPICAL | ANDA | 22 sections |
| Hydrocortisone Valerate | HUMAN PRESCRIPTION DRUG LABEL | 1 | 51672-1290 | CREAM | 2 mg | TOPICAL | ANDA | 22 sections |
| Hydrocortisone Valerate | HUMAN PRESCRIPTION DRUG LABEL | 1 | 51672-1292 | OINTMENT | 2 mg | TOPICAL | ANDA | 22 sections |
| Hydrocortisone Valerate | HUMAN PRESCRIPTION DRUG LABEL | 1 | 54868-4451 | CREAM | 2 mg | TOPICAL | ANDA | 11 sections |
| Hydrocortisone Valerate | HUMAN PRESCRIPTION DRUG LABEL | 1 | 54868-5251 | OINTMENT | 2 mg | TOPICAL | ANDA | 11 sections |
| HYDROCORTISONE VALERATE | HUMAN PRESCRIPTION DRUG LABEL | 1 | 61919-010 | CREAM | 2 mg | TOPICAL | ANDA | 10 sections |
| HYDROCORTISONE VALERATE | HUMAN PRESCRIPTION DRUG LABEL | 1 | 68180-954 | CREAM | 2 mg | TOPICAL | ANDA | 18 sections |
| Hydrocortisone valerate | HUMAN PRESCRIPTION DRUG LABEL | 1 | 68462-575 | CREAM | 2 mg | TOPICAL | ANDA | 19 sections |
| Hydrocortisone Valerate | HUMAN PRESCRIPTION DRUG LABEL | 1 | 68462-836 | OINTMENT | 2 mg | TOPICAL | ANDA | 19 sections |