hydrocortisone valerate 🐶 Veterinary Use | Indications/Contra | FAERs-F | FAERs-M | Orange Bk | BioActivity |

Stem definitionDrug idCAS RN
corticosteroids, except prednisolone derivatives 4504 57524-89-7

Description:

MoleculeDescription

Molfile Inchi Smiles

Synonyms:

  • hydrocortisone valerate
  • hydrocortisone pentanoate
used in treatment of atopic dermatitis; RN given refers to 11beta-isomer
  • Molecular weight: 446.58
  • Formula: C26H38O6
  • CLOGP: 4.01
  • LIPINSKI: 0
  • HAC: 6
  • HDO: 2
  • TPSA: 100.90
  • ALOGS: -4.77
  • ROTB: 7

  • Status: OFP

  • Legend:
    OFP - off patent
    OFM - off market
    ONP - on patent

Drug dosage:

None

ADMET properties:

None

Approvals:

DateAgencyCompanyOrphan
March 17, 1978 FDA RANBAXY

FDA Adverse Event Reporting System (Female)

MedDRA adverse event termLikelihood ratioLikelihood ratio thresholdPatients taking drug having adverse eventPatients taking drug not having adverse eventPatients not taking drug having adverse eventPatients not taking drug not having adverse event
Osteomyelitis 48.47 35.01 14 363 22339 50582408

FDA Adverse Event Reporting System (Male)

None

FDA Adverse Event Reporting System (Geriatric)

MedDRA adverse event termLikelihood ratioLikelihood ratio thresholdPatients taking drug having adverse eventPatients taking drug not having adverse eventPatients not taking drug having adverse eventPatients not taking drug not having adverse event
Periarthritis 36.15 33.65 7 367 2560 64495798
Psoriasis 35.90 33.65 14 360 71689 64426669

FDA Adverse Event Reporting System (Pediatric)

None

Pharmacologic Action:

SourceCodeDescription
FDA MoA N0000175450 Corticosteroid Hormone Receptor Agonists
FDA EPC N0000175576 Corticosteroid
MeSH PA D000893 Anti-Inflammatory Agents
CHEBI has role CHEBI:35472 anti-inflammatory drugs
CHEBI has role CHEBI:49167 anti-asthmatic drugs
CHEBI has role CHEBI:50857 anti-allergic drugs
CHEBI has role CHEBI:75771 Mus musculus metabolites
CHEBI has role CHEBI:77746 Homo sapiens metabolite
CHEBI has role CHEBI:88188 allergenic drug

Drug Use (View source of the data)

None




🐶 Veterinary Drug Use

None

🐶 Veterinary products

None

Acid dissociation constants calculated using MoKa v3.0.0

Dissociation levelDissociation constantType (acidic/basic)
pKa1 11.48 acidic

Orange Book patent data (new drug applications)

None

Orange Book exclusivity data (new drug applications)

None

Bioactivity Summary:

TargetClassPharosUniProtActionTypeActivity value
(-log[M])
Mechanism
action
Bioact sourceMoA source
Glucocorticoid receptor Nuclear hormone receptor AGONIST CHEMBL CHEMBL

External reference:

IDSource
D02288 KEGG_DRUG
4017946 VUID
N0000179155 NUI
4017941 VANDF
4017946 VANDF
CHEBI:50865 CHEBI
CHEBI:17650 CHEBI
CHEMBL1200562 ChEMBL_ID
C038363 MESH_SUPPLEMENTAL_RECORD_UI
DB14544 DRUGBANK_ID
68717P8FUZ UNII
5282494 PUBCHEM_CID
5754 PUBCHEM_CID
DB00741 DRUGBANK_ID
27199 RXNORM
11849 MMSL
2500 MMSL
4837 MMSL
4844 MMSL
d00254 MMSL
002147 NDDF
002153 NDDF
16602005 SNOMEDCT_US
396458002 SNOMEDCT_US
51612003 SNOMEDCT_US
C0063079 UMLSCUI
C0020268 UMLSCUI
38 INN_ID
D006854 MESH_DESCRIPTOR_UI

Pharmaceutical products:

ProductCategoryIngredientsNDCFormQuantityRouteMarketingLabel
Hydrocortisone Valerate HUMAN PRESCRIPTION DRUG LABEL 1 0713-0560 OINTMENT 2 mg TOPICAL ANDA 21 sections
Hydrocortisone Valerate HUMAN PRESCRIPTION DRUG LABEL 1 0713-0560 OINTMENT 2 mg TOPICAL ANDA 21 sections
Hydrocortisone Valerate HUMAN PRESCRIPTION DRUG LABEL 1 0713-0668 CREAM 2 mg TOPICAL ANDA 22 sections
Hydrocortisone Valerate HUMAN PRESCRIPTION DRUG LABEL 1 0713-0669 OINTMENT 2 mg TOPICAL ANDA 22 sections
HYDROCORTISONE VALERATE HUMAN PRESCRIPTION DRUG LABEL 1 0713-0720 CREAM 2 mg TOPICAL ANDA 18 sections
Hydrocortisone Valerate HUMAN PRESCRIPTION DRUG LABEL 1 21695-730 CREAM 2 mg TOPICAL ANDA 22 sections
hydrocortisone valerate cream HUMAN PRESCRIPTION DRUG LABEL 1 21922-007 CREAM 2 mg TOPICAL ANDA 18 sections
hydrocortisone valerate cream HUMAN PRESCRIPTION DRUG LABEL 1 21922-007 CREAM 2 mg TOPICAL ANDA 18 sections
Hydrocortisone Valerate HUMAN PRESCRIPTION DRUG LABEL 1 45802-455 CREAM 2 mg TOPICAL ANDA 22 sections
Hydrocortisone Valerate HUMAN PRESCRIPTION DRUG LABEL 1 50090-2525 CREAM 2 mg TOPICAL ANDA 22 sections
Hydrocortisone Valerate HUMAN PRESCRIPTION DRUG LABEL 1 51672-1290 CREAM 2 mg TOPICAL ANDA 22 sections
Hydrocortisone Valerate HUMAN PRESCRIPTION DRUG LABEL 1 51672-1292 OINTMENT 2 mg TOPICAL ANDA 22 sections
Hydrocortisone Valerate HUMAN PRESCRIPTION DRUG LABEL 1 54868-4451 CREAM 2 mg TOPICAL ANDA 11 sections
Hydrocortisone Valerate HUMAN PRESCRIPTION DRUG LABEL 1 54868-5251 OINTMENT 2 mg TOPICAL ANDA 11 sections
HYDROCORTISONE VALERATE HUMAN PRESCRIPTION DRUG LABEL 1 61919-010 CREAM 2 mg TOPICAL ANDA 10 sections
HYDROCORTISONE VALERATE HUMAN PRESCRIPTION DRUG LABEL 1 68180-954 CREAM 2 mg TOPICAL ANDA 18 sections
Hydrocortisone valerate HUMAN PRESCRIPTION DRUG LABEL 1 68462-575 CREAM 2 mg TOPICAL ANDA 19 sections
Hydrocortisone Valerate HUMAN PRESCRIPTION DRUG LABEL 1 68462-836 OINTMENT 2 mg TOPICAL ANDA 19 sections