hydrocortisone valerate Indications/Contra | FAERs-F | FAERs-M | Orange Bk | BioActivity |

Stem definitionDrug idCAS RN
corticosteroids, except prednisolone derivatives 4504 57524-89-7

Description:

MoleculeDescription

Molfile Inchi Smiles

Synonyms:

  • hydrocortisone valerate
  • hydrocortisone pentanoate
used in treatment of atopic dermatitis; RN given refers to 11beta-isomer
  • Molecular weight: 446.58
  • Formula: C26H38O6
  • CLOGP: 4.01
  • LIPINSKI: 0
  • HAC: 6
  • HDO: 2
  • TPSA: 100.90
  • ALOGS: -4.77
  • ROTB: 7

  • Status: OFP

  • Legend:
    OFP - off patent
    OFM - off market
    ONP - on patent

Drug dosage:

None

ADMET properties:

None

Approvals:

DateAgencyCompanyOrphan
March 17, 1978 FDA RANBAXY

FDA Adverse Event Reporting System (Female)

None

FDA Adverse Event Reporting System (Male)

None

Pharmacologic Action:

None

Drug Use (View source of the data)

None

Acid dissociation constants calculated using MoKa v3.0.0

Dissociation levelDissociation constantType (acidic/basic)
pKa1 11.48 acidic

Orange Book patent data (new drug applications)

None

Orange Book exclusivity data (new drug applications)

None

Bioactivity Summary:

TargetClassPharosUniProtActionTypeActivity value
(-log[M])
Mechanism
action
Bioact sourceMoA source
Glucocorticoid receptor Nuclear hormone receptor AGONIST CHEMBL CHEMBL

External reference:

IDSource
D02288 KEGG_DRUG
4017946 VUID
N0000179155 NUI
4017946 VANDF
C0063079 UMLSCUI
CHEBI:50865 CHEBI
CHEMBL1200562 ChEMBL_ID
DB14544 DRUGBANK_ID
C038363 MESH_SUPPLEMENTAL_RECORD_UI
68717P8FUZ UNII
5282494 PUBCHEM_CID
27199 RXNORM
11849 MMSL
4844 MMSL
002153 NDDF
51612003 SNOMEDCT_US

Pharmaceutical products:

ProductCategoryIngredientsNDCFormQuantityRouteMarketingLabel
Hydrocortisone Valerate HUMAN PRESCRIPTION DRUG LABEL 1 0713-0560 OINTMENT 2 mg TOPICAL ANDA 21 sections
Hydrocortisone Valerate HUMAN PRESCRIPTION DRUG LABEL 1 0713-0668 CREAM 2 mg TOPICAL ANDA 22 sections
Hydrocortisone Valerate HUMAN PRESCRIPTION DRUG LABEL 1 0713-0669 OINTMENT 2 mg TOPICAL ANDA 22 sections
Hydrocortisone Valerate HUMAN PRESCRIPTION DRUG LABEL 1 21695-730 CREAM 2 mg TOPICAL ANDA 22 sections
Hydrocortisone Valerate HUMAN PRESCRIPTION DRUG LABEL 1 45802-455 CREAM 2 mg TOPICAL ANDA 22 sections
Hydrocortisone Valerate HUMAN PRESCRIPTION DRUG LABEL 1 50090-2525 CREAM 2 mg TOPICAL ANDA 22 sections
Hydrocortisone Valerate HUMAN PRESCRIPTION DRUG LABEL 1 51672-1290 CREAM 2 mg TOPICAL ANDA 22 sections
Hydrocortisone Valerate HUMAN PRESCRIPTION DRUG LABEL 1 51672-1292 OINTMENT 2 mg TOPICAL ANDA 22 sections
Hydrocortisone Valerate HUMAN PRESCRIPTION DRUG LABEL 1 54868-4451 CREAM 2 mg TOPICAL ANDA 11 sections
Hydrocortisone Valerate HUMAN PRESCRIPTION DRUG LABEL 1 54868-5251 OINTMENT 2 mg TOPICAL ANDA 11 sections
HYDROCORTISONE VALERATE HUMAN PRESCRIPTION DRUG LABEL 1 61919-010 CREAM 2 mg TOPICAL ANDA 10 sections
HYDROCORTISONE VALERATE HUMAN PRESCRIPTION DRUG LABEL 1 68180-954 CREAM 2 mg TOPICAL ANDA 18 sections
Hydrocortisone valerate HUMAN PRESCRIPTION DRUG LABEL 1 68462-575 CREAM 2 mg TOPICAL ANDA 19 sections
Hydrocortisone Valerate HUMAN PRESCRIPTION DRUG LABEL 1 68462-836 OINTMENT 2 mg TOPICAL ANDA 19 sections