diflorasone diacetate Indications/Contra | FAERs-F | FAERs-M | Orange Bk | BioActivity |

Stem definitionDrug idCAS RN
4485 33564-31-7

Description:

MoleculeDescription

Molfile Inchi Smiles

Synonyms:

  • dermaflor
  • diacort
  • diflorasone diacetate
topical corticosteroid has anti-inflammatory, anti-pruritic, and vasoconstrictive actions
  • Molecular weight: 494.53
  • Formula: C26H32F2O7
  • CLOGP: 2.90
  • LIPINSKI: 0
  • HAC: 7
  • HDO: 1
  • TPSA: 106.97
  • ALOGS: -4.63
  • ROTB: 6

  • Status: OFP

  • Legend:
    OFP - off patent
    OFM - off market
    ONP - on patent

Drug dosage:

None

ADMET properties:

None

Approvals:

DateAgencyCompanyOrphan
Sept. 14, 1977 FDA PHARMACIA AND UPJOHN

FDA Adverse Event Reporting System (Female)

None

FDA Adverse Event Reporting System (Male)

None

Pharmacologic Action:

SourceCodeDescription
ATC D07AC10 DERMATOLOGICALS
CORTICOSTEROIDS, DERMATOLOGICAL PREPARATIONS
CORTICOSTEROIDS, PLAIN
Corticosteroids, potent (group III)
MeSH PA D000893 Anti-Inflammatory Agents
MeSH PA D005938 Glucocorticoids
MeSH PA D006728 Hormones
FDA EPC N0000175576 Corticosteroid
FDA MoA N0000175450 Corticosteroid Hormone Receptor Agonists

Drug Use (View source of the data)

DiseaseRelationSNOMED_IDDOID
Atopic dermatitis indication 24079001 DOID:3310
Contact dermatitis indication 40275004 DOID:2773
Seborrheic dermatitis indication 50563003 DOID:8741
Lichen simplex chronicus indication 53891004
Granuloma annulare indication 65508009 DOID:3777
Pruritus ani indication 90446007
Discoid lupus erythematosus indication 200938002
Plaque psoriasis indication 200965009
Scalp psoriasis indication 238608008
Pruritus of genital organs indication 267802000
Eruption of skin indication 271807003 DOID:0050486
Primary cutaneous T-cell lymphoma indication 400122007
Telangiectasia disorder contraindication 247479008
Adrenal cortical hypofunction contraindication 386584007 DOID:10493
Atrophoderma contraindication 399979006
Peripheral vascular disease contraindication 400047006

Acid dissociation constants calculated using MoKa v3.0.0

Dissociation levelDissociation constantType (acidic/basic)
pKa1 11.48 acidic

Orange Book patent data (new drug applications)

None

Orange Book exclusivity data (new drug applications)

None

Bioactivity Summary:

TargetClassPharosUniProtActionTypeActivity value
(-log[M])
Mechanism
action
Bioact sourceMoA source
Glucocorticoid receptor Nuclear hormone receptor AGONIST Ki 8.54 DRUG MATRIX CHEMBL
Progesterone receptor Transcription factor Ki 7.82 DRUG MATRIX

External reference:

IDSource
D01327 KEGG_DRUG
4018081 VUID
N0000179106 NUI
C0057992 UMLSCUI
7W2J09SCWX UNII
CHEMBL1200545 ChEMBL_ID
3314 INN_ID
2557-49-5 SECONDARY_CAS_RN
7068 IUPHAR_LIGAND_ID
CHEMBL1201380 ChEMBL_ID
DB00223 DRUGBANK_ID
71414 PUBCHEM_CID
C014477 MESH_SUPPLEMENTAL_RECORD_UI
4018081 VANDF
4594 MMSL
23033 RXNORM
38446009 SNOMEDCT_US
11711 MMSL
002201 NDDF

Pharmaceutical products:

ProductCategoryIngredientsNDCFormQuantityRouteMarketingLabel
Diflorasone Diacetate HUMAN PRESCRIPTION DRUG LABEL 1 0168-0242 CREAM 0.50 mg TOPICAL ANDA 11 sections
Diflorasone Diacetate HUMAN PRESCRIPTION DRUG LABEL 1 0168-0243 OINTMENT 0.50 mg TOPICAL ANDA 11 sections
Diflorasone Diacetate HUMAN PRESCRIPTION DRUG LABEL 1 0168-0353 CREAM 0.50 mg TOPICAL ANDA 11 sections
ApexiCon E HUMAN PRESCRIPTION DRUG LABEL 1 10337-395 CREAM 0.50 mg TOPICAL ANDA 12 sections
Diflorasone Diacetate HUMAN PRESCRIPTION DRUG LABEL 1 51672-1295 OINTMENT 0.50 mg TOPICAL ANDA 11 sections
Diflorasone Diacetate HUMAN PRESCRIPTION DRUG LABEL 1 51672-1296 CREAM 0.50 mg TOPICAL ANDA 11 sections
psorcon HUMAN PRESCRIPTION DRUG LABEL 1 51672-5292 CREAM 5 mg TOPICAL ANDA 11 sections
Diflorasone Diacetate HUMAN PRESCRIPTION DRUG LABEL 1 52565-063 OINTMENT 0.50 mg TOPICAL ANDA 12 sections
Diflorasone Diacetate HUMAN PRESCRIPTION DRUG LABEL 1 61748-350 OINTMENT 0.50 mg TOPICAL ANDA 11 sections
Diflorasone Diacetate Oint HUMAN PRESCRIPTION DRUG LABEL 1 70512-031 OINTMENT 0.50 mg TOPICAL ANDA 11 sections
Diflorasone Diacetate HUMAN PRESCRIPTION DRUG LABEL 1 71800-009 OINTMENT 0.50 mg TOPICAL ANDA 11 sections