corbadrine Indications/Contra | FAERs-F | FAERs-M | Orange Bk | BioActivity |

Stem definitionDrug idCAS RN
sympathomimetics 4482 829-74-3

Description:

MoleculeDescription

Molfile Inchi Smiles

Synonyms:

  • levonordefrin
  • corbadrine
  • (-)-alpha-(1-Aminoethyl)-3,4-dihydroxybenzyl alcohol
  • levoepinefrina
  • Molecular weight: 183.21
  • Formula: C9H13NO3
  • CLOGP: -0.68
  • LIPINSKI: 0
  • HAC: 4
  • HDO: 4
  • TPSA: 86.71
  • ALOGS: -1.10
  • ROTB: 2

  • Status: OFP

  • Legend:
    OFP - off patent
    OFM - off market
    ONP - on patent

Drug dosage:

None

ADMET properties:

None

Approvals:

DateAgencyCompanyOrphan
Jan. 6, 1960 FDA EASTMAN KODAK

FDA Adverse Event Reporting System (Female)

None

FDA Adverse Event Reporting System (Male)

None

Pharmacologic Action:

SourceCodeDescription
CHEBI has role CHEBI:35569 alpha-adrenergic agonist
CHEBI has role CHEBI:50514 vasoconstrictor agent
CHEBI has role CHEBI:77715 nasal decongestant

Drug Use (View source of the data)

None

Acid dissociation constants calculated using MoKa v3.0.0

Dissociation levelDissociation constantType (acidic/basic)
pKa1 9.45 acidic
pKa2 12.29 acidic
pKa3 12.9 acidic
pKa4 8.73 Basic

Orange Book patent data (new drug applications)

None

Orange Book exclusivity data (new drug applications)

None

Bioactivity Summary:

TargetClassPharosUniProtActionTypeActivity value
(-log[M])
Mechanism
action
Bioact sourceMoA source
Adrenergic receptor alpha-2 GPCR AGONIST CHEMBL CHEMBL
Alpha-1D adrenergic receptor GPCR AGONIST Ki 5.60 IUPHAR
Adrenergic receptor alpha-2 GPCR Ki 6.69 CHEMBL
Adrenergic receptor alpha-1 GPCR Ki 5.44 CHEMBL

External reference:

IDSource
D02388 KEGG_DRUG
4018992 VUID
N0000147269 NUI
C0520472 UMLSCUI
CHEMBL677 ChEMBL_ID
V008L6478D UNII
50 INN_ID
DB06707 DRUGBANK_ID
CHEBI:141146 CHEBI
508 IUPHAR_LIGAND_ID
164739 PUBCHEM_CID
387230002 SNOMEDCT_US
41470001 SNOMEDCT_US
132889 RXNORM
d05369 MMSL
001789 NDDF
4018992 VANDF

Pharmaceutical products:

ProductCategoryIngredientsNDCFormQuantityRouteMarketingLabel
Carbocaine with Neo-Cobefrin HUMAN PRESCRIPTION DRUG LABEL 2 0362-0931 INJECTION, SOLUTION 0.05 mg SUBCUTANEOUS ANDA 12 sections
Scandonest 2% L HUMAN PRESCRIPTION DRUG LABEL 2 0362-1097 INJECTION, SOLUTION 0.05 mg SUBCUTANEOUS ANDA 2 sections
Carbocaine with Neo-Cobefrin HUMAN PRESCRIPTION DRUG LABEL 2 31382-931 INJECTION, SOLUTION 0.05 mg SUBCUTANEOUS ANDA 12 sections
Scandonest L HUMAN PRESCRIPTION DRUG LABEL 2 51004-1097 INJECTION, SOLUTION 0.05 mg SUBCUTANEOUS ANDA 2 sections
Mepivacaine Hydrochloride and Levonordefrin HUMAN PRESCRIPTION DRUG LABEL 2 66467-9790 INJECTION, SOLUTION 0.05 mg SUBCUTANEOUS ANDA 12 sections