corbadrine 🐶 Veterinary Use | Indications/Contra | FAERs-F | FAERs-M | Orange Bk | BioActivity |

Stem definitionDrug idCAS RN
sympathomimetics 4482 829-74-3

Description:

MoleculeDescription

Molfile Inchi Smiles

Synonyms:

  • levonordefrin
  • corbadrine
  • (-)-alpha-(1-Aminoethyl)-3,4-dihydroxybenzyl alcohol
  • levoepinefrina
  • Molecular weight: 183.21
  • Formula: C9H13NO3
  • CLOGP: -0.68
  • LIPINSKI: 0
  • HAC: 4
  • HDO: 4
  • TPSA: 86.71
  • ALOGS: -1.10
  • ROTB: 2

  • Status: OFP

  • Legend:
    OFP - off patent
    OFM - off market
    ONP - on patent

Drug dosage:

None

ADMET properties:

None

Approvals:

DateAgencyCompanyOrphan
Jan. 6, 1960 FDA EASTMAN KODAK

FDA Adverse Event Reporting System (Female)

None

FDA Adverse Event Reporting System (Male)

None

FDA Adverse Event Reporting System (Geriatric)

None

FDA Adverse Event Reporting System (Pediatric)

None

Pharmacologic Action:

SourceCodeDescription
MeSH PA D002317 Cardiovascular Agents
MeSH PA D014662 Vasoconstrictor Agents
CHEBI has role CHEBI:35569 alpha-adrenergic agonists
CHEBI has role CHEBI:77715 nasal decongestants

Drug Use | Suggest Off label Use Form| |View source of the data|

None




🐶 Veterinary Drug Use

None

🐶 Veterinary products

None

Acid dissociation constants calculated using MoKa v3.0.0

Dissociation levelDissociation constantType (acidic/basic)
pKa1 9.45 acidic
pKa2 12.29 acidic
pKa3 12.9 acidic
pKa4 8.73 Basic

Orange Book patent data (new drug applications)

None

Orange Book exclusivity data (new drug applications)

None

Bioactivity Summary:

TargetClassPharosUniProtActionTypeActivity value
(-log[M])
Mechanism
action
Bioact sourceMoA source
Adrenergic receptor alpha-2 GPCR AGONIST CHEMBL CHEMBL
Alpha-1D adrenergic receptor GPCR AGONIST Ki 5.60 IUPHAR
Adrenergic receptor alpha-2 GPCR Ki 6.69 CHEMBL
Adrenergic receptor alpha-1 GPCR Ki 5.44 CHEMBL

External reference:

IDSource
D02388 KEGG_DRUG
4018992 VUID
N0000147269 NUI
4018992 VANDF
CHEBI:141146 CHEBI
CHEMBL677 ChEMBL_ID
508 IUPHAR_LIGAND_ID
DB06707 DRUGBANK_ID
132889 RXNORM
d05369 MMSL
001789 NDDF
387230002 SNOMEDCT_US
41470001 SNOMEDCT_US
C0520472 UMLSCUI
D008771 MESH_DESCRIPTOR_UI
50 INN_ID
164739 PUBCHEM_CID
V008L6478D UNII

Pharmaceutical products:

ProductCategoryIngredientsNDCFormQuantityRouteMarketingLabel
Carbocaine with Neo-Cobefrin HUMAN PRESCRIPTION DRUG LABEL 2 0362-0931 INJECTION, SOLUTION 0.05 mg SUBCUTANEOUS ANDA 20 sections
Scandonest 2% L HUMAN PRESCRIPTION DRUG LABEL 2 0362-1097 INJECTION, SOLUTION 0.05 mg SUBCUTANEOUS ANDA 2 sections
Carbocaine with Neo-Cobefrin HUMAN PRESCRIPTION DRUG LABEL 2 31382-931 INJECTION, SOLUTION 0.05 mg SUBCUTANEOUS ANDA 20 sections