phosphoric acid 🐶 Veterinary Use | Indications/Contra | FAERs-F | FAERs-M | Orange Bk | BioActivity |

Stem definition	Drug id	CAS RN
	4478	7664-38-2

Description:

Molecule	Description
Molfile Inchi Smiles Synonyms: phosphoric acid	concise etchant is 37% H3PO4 Molecular weight: 97.99 Formula: H3O4P CLOGP: -2.17 LIPINSKI: None HAC: 4 HDO: 3 TPSA: 77.76 ALOGS: ROTB: 0

Molecule

Description

Molfile Inchi Smiles

Synonyms:

phosphoric acid

concise etchant is 37% H3PO4

Molecular weight: 97.99
Formula: H3O4P
CLOGP: -2.17
LIPINSKI: None
HAC: 4
HDO: 3
TPSA: 77.76
ALOGS:
ROTB: 0

Drug dosage:

None

ADMET properties:

None

Approvals:

Date	Agency	Company	Orphan
Sept. 24, 1971	FDA	B BRAUN

FDA Adverse Event Reporting System (Female)

MedDRA adverse event term	Likelihood ratio	Likelihood ratio threshold	Patients taking drug having adverse event	Patients taking drug not having adverse event	Patients not taking drug having adverse event	Patients not taking drug not having adverse event
Skin candida	115.92	19.61	27	5218	1628	63482149
Creatinine renal clearance decreased	114.42	19.61	45	5200	16263	63467514
Sedation complication	107.11	19.61	41	5204	13781	63469996
Balance disorder	103.46	19.61	72	5173	84350	63399427
Blood calcium decreased	102.68	19.61	48	5197	26403	63457374
Orthostatic hypotension	96.92	19.61	51	5194	36109	63447668
Constipation	80.80	19.61	96	5149	224847	63258930
Cognitive disorder	76.39	19.61	51	5194	55764	63428013
Sedation	71.99	19.61	43	5202	38766	63445011
Depressed level of consciousness	71.48	19.61	51	5194	62027	63421750
Neutropenic sepsis	58.16	19.61	28	5217	16410	63467367
Nervous system disorder	46.11	19.61	25	5220	18741	63465036
Mobility decreased	43.86	19.61	52	5193	121107	63362670
Hypomagnesaemia	43.53	19.61	28	5217	28709	63455068
Dehydration	41.93	19.61	61	5184	173293	63310484
Dysphagia	40.59	19.61	43	5202	88542	63395235
Mouth ulceration	40.02	19.61	28	5217	32956	63450821
Mucosal inflammation	39.50	19.61	32	5213	46896	63436881
Gait disturbance	39.37	19.61	61	5184	183117	63300660
Hypokalaemia	36.65	19.61	44	5201	103760	63380017
Candida infection	36.59	19.61	25	5220	28326	63455451
Oesophagitis	31.42	19.61	18	5227	14990	63468787
Productive cough	31.30	19.61	32	5213	63176	63420601
Hypotension	28.76	19.61	67	5178	272537	63211240
Neutrophil count decreased	28.74	19.61	29	5216	56377	63427400
Fall	27.71	19.61	83	5162	392251	63091526
Multiple drug therapy	25.34	19.61	10	5235	3636	63480141
Vomiting	22.12	19.61	98	5147	559519	62924258
Anaemia	20.60	19.61	62	5183	293368	63190409

FDA Adverse Event Reporting System (Male)

MedDRA adverse event term	Likelihood ratio	Likelihood ratio threshold	Patients taking drug having adverse event	Patients taking drug not having adverse event	Patients not taking drug having adverse event	Patients not taking drug not having adverse event
Periarthritis	30.37	21.26	8	2144	1076	34953703
Dehydration	27.86	21.26	37	2115	129932	34824847

FDA Adverse Event Reporting System (Geriatric)

MedDRA adverse event term	Likelihood ratio	Likelihood ratio threshold	Patients taking drug having adverse event	Patients taking drug not having adverse event	Patients not taking drug having adverse event	Patients not taking drug not having adverse event
Creatinine renal clearance decreased	134.30	17.68	51	5786	18951	79719600
Sedation complication	125.13	17.68	46	5791	15623	79722928
Blood calcium decreased	121.47	17.68	55	5782	31764	79706787
Balance disorder	117.52	17.68	79	5758	98778	79639773
Skin candida	107.77	17.68	26	5811	2061	79736490
Orthostatic hypotension	94.60	17.68	56	5781	56108	79682443
Cognitive disorder	85.73	17.68	57	5780	69869	79668682
Constipation	80.27	17.68	101	5736	282949	79455602
Sedation	75.19	17.68	47	5790	51848	79686703
Depressed level of consciousness	58.97	17.68	52	5785	96600	79641951
Mobility decreased	55.87	17.68	56	5781	122119	79616432
Neutropenic sepsis	48.20	17.68	28	5809	27036	79711515
Nervous system disorder	43.15	17.68	26	5811	26830	79711721
Dehydration	42.82	17.68	70	5767	248117	79490434
Mouth ulceration	36.95	17.68	27	5810	38367	79700184
Dysphagia	35.17	17.68	44	5793	122092	79616459
Fall	34.99	17.68	96	5741	487533	79251018
Candida infection	34.81	17.68	26	5811	38188	79700363
Hypomagnesaemia	34.25	17.68	28	5809	46883	79691668
Mucosal inflammation	29.76	17.68	32	5805	75548	79663003
Hypotension	28.93	17.68	84	5753	440233	79298318
Gait disturbance	28.55	17.68	53	5784	207453	79531098
Multiple drug therapy	25.42	17.68	10	5827	4068	79734483
Hypokalaemia	25.31	17.68	41	5796	143999	79594552
Pain	24.49	17.68	109	5728	703693	79034858
Productive cough	22.56	17.68	30	5807	88301	79650250
Neutrophil count decreased	21.11	17.68	30	5807	93929	79644622
Bladder disorder	17.70	17.68	10	5827	9155	79729396

FDA Adverse Event Reporting System (Pediatric)

None

Pharmacologic Action:

Source	Code	Description
MeSH PA	D003764	Dental Materials
CHEBI has role	CHEBI:33287	fertilizers
CHEBI has role	CHEBI:46787	solvents
CHEBI has role	CHEBI:77746	Homo sapiens metabolite
CHEBI has role	CHEBI:84735	algal metabolites

Drug Use | Suggest Off label Use Form| |View source of the data|

Disease	Relation	SNOMED_ID	DOID
Nutritional support	indication	278906000

🐶 Veterinary Drug Use

None

🐶 Veterinary products

None

Acid dissociation constants calculated using MoKa v3.0.0

Dissociation level	Dissociation constant	Type (acidic/basic)
pKa1	1.0	acidic
pKa2	6.06	acidic
pKa3	11.11	acidic

Orange Book patent data (new drug applications)

None

Orange Book exclusivity data (new drug applications)

None

Bioactivity Summary:

None

External reference:

ID	Source
D05467	KEGG_DRUG
4018718	VUID
N0000178952	NUI
4018718	VANDF
CHEBI:26078	CHEBI
2HP	PDB_CHEM_ID
IPS	PDB_CHEM_ID
PI	PDB_CHEM_ID
PO4	PDB_CHEM_ID
CHEMBL1187	ChEMBL_ID
C030242	MESH_SUPPLEMENTAL_RECORD_UI
DB09394	DRUGBANK_ID
E4GA8884NN	UNII
8259	RXNORM
NOCODE	MMSL
006128	NDDF
C0031700	UMLSCUI
1004	PUBCHEM_CID

Pharmaceutical products:

Product	Category	Ingredients	NDC	Form	Quantity	Route	Marketing	Label
good sense nausea relief	HUMAN OTC DRUG LABEL	3	0113-0112	SOLUTION	21.50 mg	ORAL	Unapproved drug other	14 sections
ProcalAmine	HUMAN PRESCRIPTION DRUG LABEL	22	0264-1915	INJECTION	0.04 g	INTRAVENOUS	NDA	24 sections
FreAmine III	HUMAN PRESCRIPTION DRUG LABEL	16	0264-9010	INJECTION, SOLUTION	0.12 g	INTRAVENOUS	NDA	24 sections
FreAmine III	HUMAN PRESCRIPTION DRUG LABEL	16	0264-9011	INJECTION, SOLUTION	0.12 g	INTRAVENOUS	NDA	24 sections
HepatAmine	HUMAN PRESCRIPTION DRUG LABEL	16	0264-9371	INJECTION, SOLUTION	0.12 g	INTRAVENOUS	NDA	23 sections
Nausea Relief	HUMAN OTC DRUG LABEL	3	0363-0056	SOLUTION	21.50 mg	ORAL	Unapproved drug other	14 sections
Nausea Relief	HUMAN OTC DRUG LABEL	3	0363-0056	SOLUTION	21.50 mg	ORAL	Unapproved drug other	14 sections
Anti Nausea	HUMAN OTC DRUG LABEL	3	0536-1302	LIQUID	21.50 mg	ORAL	Unapproved drug other	13 sections
Anti Nausea	HUMAN OTC DRUG LABEL	3	0536-1302	LIQUID	21.50 mg	ORAL	Unapproved drug other	13 sections
formula em	HUMAN OTC DRUG LABEL	3	0904-0049	SOLUTION	21.50 mg	ORAL	Unapproved drug other	14 sections
nausea relief	HUMAN OTC DRUG LABEL	3	11822-0401	SOLUTION	21.50 mg	ORAL	Unapproved drug other	14 sections
Select Brand Anti-Nausea	HUMAN OTC DRUG LABEL	2	15127-291	SOLUTION	21.50 mg	ORAL	unapproved drug other	11 sections
signature care anti nausea	HUMAN OTC DRUG LABEL	3	21130-694	SOLUTION	21.50 mg	ORAL	Unapproved drug other	14 sections
Kroger Anti NauseaCherry Flavor	HUMAN OTC DRUG LABEL	3	30142-708	LIQUID	21.50 mg	ORAL	Unapproved drug other	13 sections
Kroger Anti NauseaCherry Flavor	HUMAN OTC DRUG LABEL	3	30142-708	LIQUID	21.50 mg	ORAL	Unapproved drug other	13 sections
Kroger Anti NauseaCherry Flavor	HUMAN OTC DRUG LABEL	3	30142-708	LIQUID	21.50 mg	ORAL	Unapproved drug other	13 sections
nausea relief	HUMAN OTC DRUG LABEL	3	30142-709	SOLUTION	21.50 mg	ORAL	Unapproved drug other	14 sections
Anti Nausea Liquid	HUMAN OTC DRUG LABEL	3	36800-708	SOLUTION	21.50 mg	ORAL	Unapproved drug other	13 sections
Anti Nausea Liquid	HUMAN OTC DRUG LABEL	3	36800-708	SOLUTION	21.50 mg	ORAL	Unapproved drug other	13 sections
nausea relief	HUMAN OTC DRUG LABEL	3	37808-501	SOLUTION	21.50 mg	ORAL	Unapproved drug other	14 sections
HEB Anti Nausea	HUMAN OTC DRUG LABEL	3	37808-883	LIQUID	21.50 mg	ORAL	Unapproved drug other	13 sections
HEB Anti Nausea	HUMAN OTC DRUG LABEL	3	37808-883	LIQUID	21.50 mg	ORAL	Unapproved drug other	13 sections
equaline anti nausea	HUMAN OTC DRUG LABEL	3	41163-630	SOLUTION	21.50 mg	ORAL	Unapproved drug other	14 sections
Meijer Anti Nausea	HUMAN OTC DRUG LABEL	3	41250-495	LIQUID	21.50 mg	ORAL	Unapproved drug other	13 sections
Meijer Anti Nausea	HUMAN OTC DRUG LABEL	3	41250-495	LIQUID	21.50 mg	ORAL	Unapproved drug other	13 sections
Nausea Relief	HUMAN OTC DRUG LABEL	3	41250-502	SOLUTION	21.50 mg	ORAL	Unapproved drug other	14 sections
Good Neighbor Pharmacy Nausea Relief	HUMAN OTC DRUG LABEL	3	46122-296	SOLUTION	21.50 mg	ORAL	Unapproved drug other	14 sections
Good Neighbor Anti NauseaCherry Flavor	HUMAN OTC DRUG LABEL	3	46122-729	LIQUID	21.50 mg	ORAL	Unapproved drug other	13 sections
Good Neighbor Anti NauseaCherry Flavor	HUMAN OTC DRUG LABEL	3	46122-729	LIQUID	21.50 mg	ORAL	Unapproved drug other	13 sections
sunmark anti nausea	HUMAN OTC DRUG LABEL	3	49348-576	SOLUTION	21.50 mg	ORAL	Unapproved drug other	14 sections