sodium citrate 🐶 Veterinary Use | Indications/Contra | FAERs-F | FAERs-M | Orange Bk | BioActivity |

Stem definition	Drug id	CAS RN
	4477	68-04-2

Description:

Molecule	Description
Synonyms: sodium citrate trisodium citrate	Sodium salts of citric acid that are used as buffers and food preservatives. They are used medically as anticoagulants in stored blood, and for urine alkalization in the prevention of KIDNEY STONES. Molecular weight: 258.07 Formula: C6H5Na3O7 CLOGP: LIPINSKI: None HAC: None HDO: None TPSA: 140.62 ALOGS: ROTB: None

Molecule

Description

Synonyms:

sodium citrate
trisodium citrate

Sodium salts of citric acid that are used as buffers and food preservatives. They are used medically as anticoagulants in stored blood, and for urine alkalization in the prevention of KIDNEY STONES.

Molecular weight: 258.07
Formula: C6H5Na3O7
CLOGP:
LIPINSKI: None
HAC: None
HDO: None
TPSA: 140.62
ALOGS:
ROTB: None

Drug dosage:

None

ADMET properties:

None

Approvals:

Date	Agency	Company	Orphan
Oct. 3, 1980	FDA	B BRAUN

FDA Adverse Event Reporting System (Female)

MedDRA adverse event term	Likelihood ratio	Likelihood ratio threshold	Patients taking drug having adverse event	Patients taking drug not having adverse event	Patients not taking drug having adverse event	Patients not taking drug not having adverse event
Paraesthesia	12943.57	199.11	3835	17864	153131	63314192
Feeling hot	7743.08	199.11	2025	19674	48329	63418994
Pallor	7659.76	199.11	1820	19879	28748	63438575
Hyperhidrosis	4203.46	199.11	1515	20184	106321	63361002
Thirst	4024.82	199.11	936	20763	13105	63454218
Dizziness	3542.92	199.11	2034	19665	427891	63039432
Nausea	2360.12	199.11	2074	19625	852397	62614926
Dysgeusia	2030.73	199.11	715	20984	45995	63421328
Vision blurred	2006.95	199.11	852	20847	91072	63376251
Asthenia	1133.20	199.11	977	20722	382627	63084696
Dyspepsia	921.96	199.11	519	21180	101677	63365646
Restlessness	915.51	199.11	353	21346	29100	63438223
Chills	751.04	199.11	472	21227	112906	63354417
Injection site haematoma	506.58	199.11	157	21542	6675	63460648
Toxic anterior segment syndrome	258.51	199.11	69	21630	1702	63465621
Fatigue	225.61	199.11	22	21677	888006	62579317
Drug ineffective	223.24	199.11	44	21655	1044721	62422602

FDA Adverse Event Reporting System (Male)

MedDRA adverse event term	Likelihood ratio	Likelihood ratio threshold	Patients taking drug having adverse event	Patients taking drug not having adverse event	Patients not taking drug having adverse event	Patients not taking drug not having adverse event
Paraesthesia	5094.07	177.73	1496	9330	62676	34883429
Feeling hot	2468.56	177.73	660	10166	18712	34927393
Pallor	2258.07	177.73	653	10173	24827	34921278
Thirst	1480.80	177.73	367	10459	7528	34938577
Hyperhidrosis	1411.00	177.73	608	10218	75084	34871021
Dizziness	1000.58	177.73	691	10135	217830	34728275
Nausea	927.80	177.73	789	10037	339119	34606986
Dysgeusia	876.14	177.73	323	10503	26174	34919931
Vision blurred	568.68	177.73	279	10547	45684	34900421
Appendicolith	378.83	177.73	130	10696	8471	34937634
Restlessness	361.01	177.73	170	10656	25312	34920793
Dyspepsia	352.16	177.73	188	10638	36544	34909561
Injection site haematoma	333.83	177.73	83	10743	1702	34944403
Appendicitis	310.11	177.73	130	10696	14677	34931428
Chills	291.04	177.73	223	10603	80820	34865285
Toxic anterior segment syndrome	252.27	177.73	61	10765	1108	34944997
Cardiogenic shock	240.26	177.73	131	10695	26487	34919618
Asthenia	235.24	177.73	331	10495	244920	34701185
Stress	226.88	177.73	132	10694	30215	34915890

FDA Adverse Event Reporting System (Geriatric)

MedDRA adverse event term	Likelihood ratio	Likelihood ratio threshold	Patients taking drug having adverse event	Patients taking drug not having adverse event	Patients not taking drug having adverse event	Patients not taking drug not having adverse event
Paraesthesia	18162.07	137.21	5331	27105	170992	79540960
Feeling hot	10084.80	137.21	2685	29751	57049	79654903
Pallor	9506.82	137.21	2472	29964	47590	79664362
Hyperhidrosis	5516.67	137.21	2122	30314	149370	79562582
Thirst	5433.19	137.21	1302	31134	17317	79694635
Dizziness	4518.40	137.21	2724	29712	523717	79188235
Nausea	3336.55	137.21	2863	29573	954333	78757619
Dysgeusia	2940.28	137.21	1037	31399	56140	79655812
Vision blurred	2619.99	137.21	1129	31307	104769	79607183
Asthenia	1321.47	137.21	1307	31129	510382	79201570
Dyspepsia	1303.92	137.21	707	31729	107980	79603972
Restlessness	1236.14	137.21	523	31913	45969	79665983
Chills	1021.29	137.21	695	31741	159539	79552413
Injection site haematoma	916.27	137.21	240	32196	4587	79707365
Toxic anterior segment syndrome	413.90	137.21	114	32322	2650	79709302
Appendicolith	340.84	137.21	129	32307	8422	79703530
Tetany	311.26	137.21	91	32345	2637	79709315
Drug ineffective	292.23	137.21	46	32390	1080867	78631085
Diarrhoea	291.14	137.21	17	32419	880472	78831480
Fatigue	279.18	137.21	28	32408	929699	78782253
Pyrexia	237.36	137.21	9	32427	678700	79033252
Neck pain	232.89	137.21	214	32222	75203	79636749
Appendicitis	231.17	137.21	129	32307	20665	79691287
Palpitations	193.92	137.21	248	32188	126362	79585590
Dyspnoea	186.09	137.21	59	32377	856966	78854986
Arthralgia	179.98	137.21	14	32422	571789	79140163
Abdominal pain	179.47	137.21	450	31986	389119	79322833
Rash	176.98	137.21	16	32420	578342	79133610
Pneumonia	169.35	137.21	32	32404	660214	79051738
Cardiogenic shock	151.34	137.21	130	32306	41784	79670168
Fall	150.45	137.21	13	32423	487616	79224336
Malaise	145.98	137.21	15	32421	489854	79222098
Toxicity to various agents	139.36	137.21	8	32428	421532	79290420

FDA Adverse Event Reporting System (Pediatric)

None

Pharmacologic Action:

Source	Code	Description
ATC	B05CB02	BLOOD AND BLOOD FORMING ORGANS BLOOD SUBSTITUTES AND PERFUSION SOLUTIONS IRRIGATING SOLUTIONS Salt solutions
MeSH PA	D000925	Anticoagulants
MeSH PA	D002021	Buffers
MeSH PA	D005503	Food Additives
MeSH PA	D005520	Food Preservatives
MeSH PA	D006401	Hematologic Agents
CHEBI has role	CHEBI:50249	anticoagulants
CHEBI has role	CHEBI:35617	flavouring agents

Drug Use | Suggest Off label Use Form| |View source of the data|

Disease	Relation	SNOMED_ID	DOID
Peptic ulcer	indication	13200003	DOID:750
Heartburn	indication	16331000
Cough	indication	49727002
Nasal discharge	indication	64531003
Nasal congestion	indication	68235000
Rhinitis	indication	70076002	DOID:4483
Common cold	indication	82272006	DOID:10459
Indigestion	indication	162031009
Gastroesophageal reflux disease	indication	235595009	DOID:8534
Gastric Hypersecretory Conditions	indication
Hiatal Hernia with Reflux Esophagitis	indication
Renal tubular acidosis	off-label use	1776003	DOID:14219
Multiple endocrine adenomas	off-label use	60549007
Cystinuria	off-label use	85020001	DOID:9266
Systemic mast cell disease	off-label use	397016004	DOID:349
Calcium renal calculus	off-label use	427649000
Calcium Oxalate Renal Calculi	off-label use
Stress-Related GI Mucosal Bleeding Prevention	off-label use
Cystine Renal Calculi	off-label use
Metabolic alkalosis	contraindication	1388004
Anuria	contraindication	2472002	DOID:2983
Ocular hypertension	contraindication	4210003	DOID:9282
Hypocalcemia	contraindication	5291005
Hyperkalemia	contraindication	14140009
Pulmonary edema	contraindication	19242006	DOID:11396
Myocardial infarction	contraindication	22298006	DOID:5844
Ventricular tachycardia	contraindication	25569003
Dehydration	contraindication	34095006
Hyperthyroidism	contraindication	34486009	DOID:7998
Acute hepatitis	contraindication	37871000
Hypertensive disorder	contraindication	38341003	DOID:10763
Hypernatremia	contraindication	39355002
Chronic heart failure	contraindication	48447003
Bradycardia	contraindication	48867003
Acidosis	contraindication	51387008
Acute nephropathy	contraindication	58574008
Metabolic acidosis	contraindication	59455009
Arterial thrombosis	contraindication	65198009
Arteriosclerotic vascular disease	contraindication	72092001
Gastrointestinal hemorrhage	contraindication	74474003
Chronic idiopathic constipation	contraindication	82934008
Oliguria	contraindication	83128009
Gastrointestinal obstruction	contraindication	126765001
Partial atrioventricular block	contraindication	195039008
Acute pancreatitis	contraindication	197456007	DOID:2913
Impaired renal function disorder	contraindication	197663003
Myocardial dysfunction	contraindication	233928007
Gastroparesis	contraindication	235675006
Hyporeninemic hypoaldosteronism	contraindication	236464008
Bladder outflow obstruction	contraindication	236645006
Rhabdomyolysis	contraindication	240131006
Esophageal dysmotility	contraindication	266434009	DOID:9192
Benign prostatic hyperplasia	contraindication	266569009
Retention of urine	contraindication	267064002
Peripheral edema	contraindication	271809000
Familial hyperkalemic periodic paralysis	contraindication	304737009	DOID:14451
Primary adrenocortical insufficiency	contraindication	373662000
Adrenal cortical hypofunction	contraindication	386584007	DOID:10493
Hypoxia	contraindication	389086002
Angle-closure glaucoma	contraindication	392291006	DOID:13550
Disorder of coronary artery	contraindication	414024009
Traumatic injury	contraindication	417746004
Ketoacidosis in diabetes mellitus	contraindication	420422005	DOID:1837
Hypertensive urgency	contraindication	443482000
Azotemia	contraindication	445009001
Severe dehydration	contraindication	450316000
Genitourinary Tract Infections	contraindication
Esophageal Compression	contraindication

🐶 Veterinary Drug Use

None

🐶 Veterinary products

None

Acid dissociation constants calculated using MoKa v3.0.0

None

Orange Book patent data (new drug applications)

None

Orange Book exclusivity data (new drug applications)

None

Bioactivity Summary:

Target	Class	Pharos	UniProt	Action	Type	Activity value (-log[M])	Mechanism action	Bioact source	MoA source
Carbonic anhydrase 4	Enzyme	P22748	CAH4_HUMAN		Ki	7		CHEMBL
Carbonic anhydrase	Enzyme		CAN_CANAL		Ki	4.41		CHEMBL

External reference:

ID	Source
D05855	KEGG_DRUG
4017463	VUID
N0000145851	NUI
4017463	VANDF
CHEBI:32142	CHEBI
CHEMBL1355	ChEMBL_ID
C514290	MESH_SUPPLEMENTAL_RECORD_UI
DB09154	DRUGBANK_ID
253204	RXNORM
5226	MMSL
5479	MMSL
d03098	MMSL
000732	NDDF
000758	NDDF
002077	NDDF
002078	NDDF
002332	NDDF
412546005	SNOMEDCT_US
412547001	SNOMEDCT_US
C0142825	UMLSCUI
D000077559	MESH_DESCRIPTOR_UI
6224	PUBCHEM_CID

Pharmaceutical products:

None