Stem definition | Drug id | CAS RN |
---|---|---|
diagnostic agents, gadolinium derivatives | 4471 | 127000-20-8 |
Molecule | Description |
---|---|
Synonyms:
|
|
None
None
Date | Agency | Company | Orphan |
---|---|---|---|
Nov. 23, 2004 | FDA | BRACCO |
MedDRA adverse event term | Likelihood ratio | Likelihood ratio threshold | Patients taking drug having adverse event | Patients taking drug not having adverse event | Patients not taking drug having adverse event | Patients not taking drug not having adverse event |
---|---|---|---|---|---|---|
Nephrogenic systemic fibrosis | 556.70 | 52.62 | 120 | 4954 | 4202 | 50595848 |
Hypersensitivity | 362.12 | 52.62 | 239 | 4835 | 214922 | 50385128 |
Contrast media reaction | 298.24 | 52.62 | 56 | 5018 | 951 | 50599099 |
Urticaria | 287.84 | 52.62 | 172 | 4902 | 129389 | 50470661 |
Skin hypertrophy | 251.26 | 52.62 | 59 | 5015 | 3036 | 50597014 |
Anaphylactic reaction | 236.79 | 52.62 | 113 | 4961 | 53942 | 50546108 |
Skin induration | 223.26 | 52.62 | 53 | 5021 | 2858 | 50597192 |
Anaphylactoid reaction | 199.91 | 52.62 | 50 | 5024 | 3356 | 50596694 |
Skin tightness | 199.86 | 52.62 | 51 | 5023 | 3712 | 50596338 |
Sneezing | 174.43 | 52.62 | 62 | 5012 | 13982 | 50586068 |
Pruritus | 151.88 | 52.62 | 163 | 4911 | 283405 | 50316645 |
Vomiting | 149.20 | 52.62 | 205 | 4869 | 460553 | 50139497 |
Skin fibrosis | 139.93 | 52.62 | 29 | 5045 | 830 | 50599220 |
Erythema | 137.40 | 52.62 | 115 | 4959 | 146299 | 50453751 |
Fibrosis | 124.20 | 52.62 | 35 | 5039 | 3712 | 50596338 |
Nausea | 120.63 | 52.62 | 235 | 4839 | 705163 | 49894887 |
Throat tightness | 89.28 | 52.62 | 43 | 5031 | 20804 | 50579246 |
Throat irritation | 85.05 | 52.62 | 47 | 5027 | 30192 | 50569858 |
Feeling hot | 83.86 | 52.62 | 51 | 5023 | 39151 | 50560899 |
Skin hyperpigmentation | 75.86 | 52.62 | 26 | 5048 | 5250 | 50594800 |
Dyspnoea | 74.93 | 52.62 | 167 | 4907 | 547441 | 50052609 |
Gadolinium deposition disease | 71.28 | 52.62 | 11 | 5063 | 51 | 50599999 |
Joint contracture | 70.94 | 52.62 | 19 | 5055 | 1665 | 50598385 |
Joint range of motion decreased | 69.75 | 52.62 | 35 | 5039 | 18477 | 50581573 |
Foaming at mouth | 68.75 | 52.62 | 17 | 5057 | 1085 | 50598965 |
Peau d'orange | 68.54 | 52.62 | 12 | 5062 | 134 | 50599916 |
Emotional distress | 68.34 | 52.62 | 40 | 5034 | 28623 | 50571427 |
Scar | 68.21 | 52.62 | 30 | 5044 | 11788 | 50588262 |
Anaphylactic shock | 66.94 | 52.62 | 35 | 5039 | 20120 | 50579930 |
Contrast media allergy | 62.94 | 52.62 | 18 | 5056 | 2009 | 50598041 |
Anhedonia | 57.64 | 52.62 | 25 | 5049 | 9499 | 50590551 |
Drug ineffective | 56.07 | 52.62 | 8 | 5066 | 819325 | 49780725 |
Skin discolouration | 56.00 | 52.62 | 37 | 5037 | 32720 | 50567330 |
MedDRA adverse event term | Likelihood ratio | Likelihood ratio threshold | Patients taking drug having adverse event | Patients taking drug not having adverse event | Patients not taking drug having adverse event | Patients not taking drug not having adverse event |
---|---|---|---|---|---|---|
Nephrogenic systemic fibrosis | 379.50 | 56.07 | 87 | 3033 | 3855 | 29567552 |
Hypersensitivity | 290.55 | 56.07 | 131 | 2989 | 52772 | 29518635 |
Urticaria | 172.59 | 56.07 | 93 | 3027 | 54567 | 29516840 |
Vomiting | 172.13 | 56.07 | 156 | 2964 | 212104 | 29359303 |
Anaphylactic reaction | 165.96 | 56.07 | 73 | 3047 | 27500 | 29543907 |
Skin induration | 158.79 | 56.07 | 38 | 3082 | 2016 | 29569391 |
Skin hypertrophy | 157.90 | 56.07 | 39 | 3081 | 2364 | 29569043 |
Nausea | 157.47 | 56.07 | 171 | 2949 | 289084 | 29282323 |
Sneezing | 156.90 | 56.07 | 44 | 3076 | 4370 | 29567037 |
Anaphylactoid reaction | 150.44 | 56.07 | 36 | 3084 | 1909 | 29569498 |
Skin tightness | 144.93 | 56.07 | 35 | 3085 | 1929 | 29569478 |
Contrast media reaction | 140.39 | 56.07 | 29 | 3091 | 776 | 29570631 |
Joint contracture | 107.15 | 56.07 | 27 | 3093 | 1773 | 29569634 |
Fibrosis | 95.23 | 56.07 | 26 | 3094 | 2333 | 29569074 |
Joint range of motion decreased | 94.05 | 56.07 | 32 | 3088 | 6022 | 29565385 |
Skin fibrosis | 90.20 | 56.07 | 21 | 3099 | 986 | 29570421 |
Scar | 85.57 | 56.07 | 29 | 3091 | 5390 | 29566017 |
Anaphylactic shock | 82.32 | 56.07 | 36 | 3084 | 13300 | 29558107 |
Pruritus | 80.80 | 56.07 | 79 | 3041 | 116770 | 29454637 |
Extremity contracture | 74.97 | 56.07 | 17 | 3103 | 709 | 29570698 |
Deformity | 72.65 | 56.07 | 19 | 3101 | 1445 | 29569962 |
Emotional distress | 56.17 | 56.07 | 28 | 3092 | 13867 | 29557540 |
MedDRA adverse event term | Likelihood ratio | Likelihood ratio threshold | Patients taking drug having adverse event | Patients taking drug not having adverse event | Patients not taking drug having adverse event | Patients not taking drug not having adverse event |
---|---|---|---|---|---|---|
Nephrogenic systemic fibrosis | 576.39 | 65.25 | 131 | 6441 | 5761 | 64486399 |
Hypersensitivity | 574.30 | 65.25 | 313 | 6259 | 196139 | 64296021 |
Anaphylactic reaction | 378.19 | 65.25 | 169 | 6403 | 68495 | 64423665 |
Urticaria | 361.99 | 65.25 | 210 | 6362 | 147107 | 64345053 |
Contrast media reaction | 340.27 | 65.25 | 69 | 6503 | 1743 | 64490417 |
Anaphylactoid reaction | 314.48 | 65.25 | 77 | 6495 | 4661 | 64487499 |
Skin hypertrophy | 312.81 | 65.25 | 76 | 6496 | 4453 | 64487707 |
Skin induration | 272.74 | 65.25 | 67 | 6505 | 4108 | 64488052 |
Sneezing | 269.34 | 65.25 | 88 | 6484 | 15163 | 64476997 |
Skin tightness | 266.17 | 65.25 | 68 | 6504 | 4893 | 64487267 |
Vomiting | 244.84 | 65.25 | 289 | 6283 | 550828 | 63941332 |
Nausea | 220.84 | 65.25 | 329 | 6243 | 785471 | 63706689 |
Pruritus | 209.08 | 65.25 | 204 | 6368 | 312196 | 64179964 |
Skin fibrosis | 172.92 | 65.25 | 38 | 6534 | 1421 | 64490739 |
Erythema | 153.34 | 65.25 | 137 | 6435 | 186933 | 64305227 |
Fibrosis | 137.37 | 65.25 | 40 | 6532 | 4688 | 64487472 |
Anaphylactic shock | 133.33 | 65.25 | 64 | 6508 | 30264 | 64461896 |
Joint contracture | 125.38 | 65.25 | 32 | 6540 | 2287 | 64489873 |
Joint range of motion decreased | 117.07 | 65.25 | 51 | 6521 | 19292 | 64472868 |
Scar | 103.40 | 65.25 | 42 | 6530 | 13356 | 64478804 |
Skin hyperpigmentation | 96.47 | 65.25 | 33 | 6539 | 6518 | 64485642 |
Throat tightness | 93.13 | 65.25 | 46 | 6526 | 23114 | 64469046 |
Gadolinium deposition disease | 90.48 | 65.25 | 14 | 6558 | 65 | 64492095 |
Throat irritation | 86.20 | 65.25 | 49 | 6523 | 32662 | 64459498 |
Feeling hot | 85.69 | 65.25 | 55 | 6517 | 45608 | 64446552 |
Contrast media allergy | 84.39 | 65.25 | 23 | 6549 | 2118 | 64490042 |
Peau d'orange | 83.74 | 65.25 | 16 | 6556 | 293 | 64491867 |
Contrast media deposition | 74.83 | 65.25 | 12 | 6560 | 73 | 64492087 |
Dyspnoea | 70.36 | 65.25 | 195 | 6377 | 718479 | 63773681 |
Emotional distress | 66.59 | 65.25 | 43 | 6529 | 35995 | 64456165 |
None
Source | Code | Description |
---|---|---|
MeSH PA | D003287 | Contrast Media |
MeSH PA | D064907 | Diagnostic Uses of Chemicals |
None
None
None
None
None
None
None
ID | Source |
---|---|
4032768 | VUID |
N0000188993 | NUI |
4032768 | VANDF |
CHEMBL1200571 | ChEMBL_ID |
C064572 | MESH_SUPPLEMENTAL_RECORD_UI |
3Q6PPC19PO | UNII |
24838350 | PUBCHEM_CID |
68173 | RXNORM |
19178 | MMSL |
64278 | MMSL |
64293 | MMSL |
d05428 | MMSL |
007717 | NDDF |
414308003 | SNOMEDCT_US |
C0209453 | UMLSCUI |
Product | Category | Ingredients | NDC | Form | Quantity | Route | Marketing | Label |
---|---|---|---|---|---|---|---|---|
MultiHance | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0270-5164 | INJECTION, SOLUTION | 529 mg | INTRAVENOUS | NDA | 28 sections |
MultiHance | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0270-5264 | INJECTION, SOLUTION | 529 mg | INTRAVENOUS | NDA | 27 sections |