All FDA-approved EMA-approved PMDA-approved
Target Card Uniprot Example: P23975

manganese sulfate 🐶 Veterinary Use | Indications/Contra | FAERs-F | FAERs-M | Orange Bk | BioActivity |

Stem definition	Drug id	CAS RN
	4461	7785-87-7

Description:

Molecule	Description
Synonyms: manganese sulfate	Molecular weight: 150.99 Formula: MnO4S CLOGP: LIPINSKI: None HAC: None HDO: None TPSA: 80.26 ALOGS: ROTB: None

Drug dosage:

None

ADMET properties:

None

Approvals:

Date	Agency	Company	Orphan
None	FDA

FDA Adverse Event Reporting System (Female)

MedDRA adverse event term	Likelihood ratio	Likelihood ratio threshold	Patients taking drug having adverse event	Patients taking drug not having adverse event	Patients not taking drug having adverse event	Patients not taking drug not having adverse event
Pemphigus	1648.04	9.96	3081	370592	117085	50114366
Systemic lupus erythematosus	1536.61	9.96	3279	370394	137343	50094108
Glossodynia	1322.62	9.96	2747	370926	112822	50118629
Rheumatoid arthritis	1074.38	9.96	3612	370061	198938	50032513
Hand deformity	1054.03	9.96	2302	371371	97897	50133554
Arthropathy	948.31	9.96	2939	370734	154967	50076484
Maternal exposure during pregnancy	947.70	9.96	2961	370712	156817	50074634
Alopecia	927.44	9.96	3922	369751	241125	49990326
Abdominal discomfort	907.42	9.96	3747	369926	227894	50003557
Wound	860.72	9.96	2199	371474	103595	50127856
Completed suicide	742.24	9.96	62	373611	131827	50099624
Infusion related reaction	687.93	9.96	2774	370899	166783	50064668
Synovitis	686.08	9.96	2243	371430	121622	50109829
Pericarditis	656.78	9.96	1652	372021	77037	50154414
Anti-cyclic citrullinated peptide antibody positive	645.57	9.96	1535	372138	69052	50162399
Contraindicated product administered	631.44	9.96	2471	371202	146487	50084964
Discomfort	615.80	9.96	1980	371693	106400	50125051
Swelling	594.52	9.96	2993	370680	197879	50033572
Joint swelling	577.59	9.96	3434	370239	241852	49989599
Pain	570.13	9.96	6648	367025	572255	49659196
Toxicity to various agents	543.87	9.96	462	373211	212037	50019414
Death	448.68	9.96	1096	372577	324283	49907168
Product use issue	402.24	9.96	2170	371503	147305	50084146
Rheumatoid factor positive	395.31	9.96	1027	372646	48832	50182619
Duodenal ulcer perforation	372.44	9.96	950	372723	44661	50186790
Arthralgia	370.13	9.96	4898	368775	433804	49797647
Helicobacter infection	360.93	9.96	991	372682	48711	50182740
Drug interaction	331.27	9.96	605	373068	199016	50032435
Hepatic enzyme increased	330.81	9.96	1936	371737	135444	50096007
Drug abuse	315.86	9.96	36	373637	59810	50171641
Intentional overdose	307.40	9.96	47	373626	62457	50168994
Exposure during pregnancy	285.87	9.96	1697	371976	119318	50112133
Drug intolerance	251.65	9.96	2598	371075	216506	50014945
Hip arthroplasty	249.62	9.96	635	373038	29794	50201657
Musculoskeletal stiffness	248.70	9.96	1713	371960	126768	50104683
Therapeutic product effect decreased	239.60	9.96	1773	371900	134277	50097174
Treatment failure	234.66	9.96	1780	371893	135857	50095594
Knee arthroplasty	230.31	9.96	684	372989	35162	50196289
Febrile neutropenia	216.33	9.96	241	373432	97426	50134025
Overdose	207.06	9.96	259	373414	99468	50131983
Psoriatic arthropathy	195.44	9.96	776	372897	46256	50185195
Suicide attempt	195.05	9.96	69	373604	51663	50179788
Nasopharyngitis	194.31	9.96	2229	371444	190698	50040753
Acute kidney injury	190.88	9.96	950	372723	227108	50004343
Cardiac arrest	185.70	9.96	206	373467	83445	50148006
Depressed level of consciousness	178.34	9.96	80	373593	51873	50179578
Red blood cell sedimentation rate abnormal	169.81	9.96	374	373299	15969	50215482
Hypersensitivity	165.02	9.96	2364	371309	212797	50018654
Malignant neoplasm progression	161.06	9.96	159	373514	67965	50163486
Diarrhoea	156.85	9.96	3237	370436	585239	49646212
C-reactive protein abnormal	154.90	9.96	505	373168	27304	50204147
Disease progression	150.56	9.96	300	373373	95566	50135885
Drug hypersensitivity	148.62	9.96	1164	372509	249846	49981605
Impaired healing	148.52	9.96	953	372720	68833	50162618
Constipation	146.08	9.96	790	372883	184918	50046533
Device expulsion	145.58	9.96	20	373653	28802	50202649
Nausea	142.51	9.96	4046	369627	701352	49530099
Rheumatic fever	142.51	9.96	356	373317	16511	50214940
Drug ineffective	140.54	9.96	7388	366285	811945	49419506
Swollen joint count increased	137.49	9.96	325	373348	14548	50216903
Sickle cell anaemia with crisis	133.02	9.96	166	373507	4377	50227074
Bradycardia	132.99	9.96	168	373505	64258	50167193
Lactic acidosis	130.06	9.96	42	373631	33313	50198138
Neutropenia	127.95	9.96	609	373064	147356	50084095
Sedation	125.79	9.96	35	373638	30575	50200876
Cardiac failure	125.47	9.96	231	373442	75809	50155642
Hyponatraemia	122.01	9.96	337	373336	95802	50135649
Asthenia	121.79	9.96	1642	372031	317400	49914051
Anxiety	118.88	9.96	795	372878	176811	50054640
Tremor	117.79	9.96	443	373230	114460	50116991
Electrocardiogram QT prolonged	115.99	9.96	127	373546	51759	50179692
Hypotension	112.96	9.96	1152	372521	234317	49997134
Somnolence	110.73	9.96	680	372993	154305	50077146
Pregnancy	108.70	9.96	470	373203	29107	50202344
Dizziness	108.12	9.96	1853	371820	344516	49886935
Dyspnoea	106.76	9.96	3155	370518	544453	49686998
Fatigue	106.41	9.96	6306	367367	701295	49530156
Rash	105.93	9.96	4088	369585	433383	49798068
Respiratory arrest	104.89	9.96	45	373628	29964	50201487
Agitation	104.26	9.96	145	373528	53239	50178212
Sleep disorder due to general medical condition, insomnia type	103.77	9.96	484	373189	30963	50200488
Vomiting	102.84	9.96	2604	371069	458154	49773297
Muscle injury	101.78	9.96	542	373131	36569	50194882
Psoriasis	101.45	9.96	863	372810	68137	50163314
Renal failure	101.11	9.96	424	373249	106209	50125242
Folliculitis	100.93	9.96	563	373110	38662	50192789
Arthritis	99.16	9.96	1028	372645	85693	50145758
Live birth	97.78	9.96	305	373368	16103	50215348
Multiple sclerosis relapse	97.32	9.96	104	373569	42860	50188591
Abortion spontaneous	95.44	9.96	581	373092	41191	50190260
Lower respiratory tract infection	95.26	9.96	1099	372574	94102	50137349
Drug reaction with eosinophilia and systemic symptoms	92.59	9.96	47	373626	28377	50203074
Rhabdomyolysis	92.33	9.96	91	373582	38936	50192515
Blister	91.79	9.96	1000	372673	84418	50147033
Sopor	88.96	9.96	19	373654	19860	50211591
Intentional self-injury	88.53	9.96	30	373643	23082	50208369
Osteoarthritis	86.52	9.96	830	372843	67776	50163675
Hyperhidrosis	86.38	9.96	353	373320	89073	50142378
Neuropathy peripheral	84.91	9.96	396	373277	96361	50135090
Neoplasm progression	83.92	9.96	56	373617	29101	50202350
Condition aggravated	83.03	9.96	2822	370851	294236	49937215
Drug withdrawal syndrome	80.91	9.96	42	373631	25039	50206412
Injection site erythema	80.83	9.96	878	372795	74058	50157393
Insomnia	80.74	9.96	863	372810	174002	50057449
Cardio-respiratory arrest	78.42	9.96	176	373497	53716	50177735
Syncope	76.12	9.96	447	373226	102555	50128896
Blood pressure fluctuation	76.05	9.96	489	373184	35334	50196117
Tachycardia	75.84	9.96	429	373244	99334	50132117
Irritable bowel syndrome	74.88	9.96	642	373031	50799	50180652
Myalgia	74.62	9.96	574	373099	123745	50107706
Product quality issue	74.10	9.96	71	373602	30787	50200664
Drug dependence	73.37	9.96	27	373646	19732	50211719
Serotonin syndrome	73.12	9.96	46	373627	24667	50206784
Hypoglycaemia	72.38	9.96	182	373491	53399	50178052
Renal impairment	72.24	9.96	300	373373	75361	50156090
Joint effusion	71.19	9.96	235	373438	12786	50218665
Hepatic failure	71.07	9.96	80	373593	32203	50199248
Anaemia	70.99	9.96	1375	372298	251081	49980370
Encephalopathy	70.50	9.96	87	373586	33624	50197827
Cognitive disorder	70.17	9.96	137	373536	43986	50187465
Injection site pruritus	70.08	9.96	525	373148	39886	50191565
Hypoxia	68.79	9.96	174	373499	50949	50180502
Coma	68.03	9.96	205	373468	56674	50174777
Palmar-plantar erythrodysaesthesia syndrome	67.33	9.96	32	373641	20066	50211385
Hyperglycaemia	64.21	9.96	106	373567	36299	50195152
Caesarean section	64.10	9.96	257	373416	15382	50216069
Juvenile idiopathic arthritis	64.05	9.96	92	373581	2787	50228664
Disability assessment scale score increased	64.04	9.96	83	373590	2275	50229176
Basal cell carcinoma	63.96	9.96	341	373332	23015	50208436
Sinusitis	63.45	9.96	1679	371994	168879	50062572
Respiratory failure	63.04	9.96	404	373269	90777	50140674
Drug resistance	62.45	9.96	31	373642	18958	50212493
Red blood cell sedimentation rate increased	62.11	9.96	401	373272	29015	50202436
Intentional product misuse	61.39	9.96	161	373512	46573	50184878
Metabolic acidosis	61.35	9.96	121	373552	38704	50192747
No adverse event	60.88	9.96	96	373577	33482	50197969
Asthma	60.66	9.96	398	373275	88939	50142512
Thrombocytopenia	59.75	9.96	628	373045	127045	50104406
Feeling abnormal	59.66	9.96	615	373058	124877	50106574
Hepatic function abnormal	58.72	9.96	94	373579	32587	50198864
Cardiac failure congestive	58.27	9.96	374	373299	84008	50147443
Muscle spasms	58.18	9.96	619	373054	124934	50106517
Foot deformity	57.84	9.96	288	373385	18922	50212529
Urticaria	57.54	9.96	645	373028	128916	50102535
Ill-defined disorder	56.93	9.96	636	373037	54018	50177433
Joint laxity	56.86	9.96	79	373594	2319	50229132
Balance disorder	56.69	9.96	298	373375	70292	50161159
Contusion	56.43	9.96	1152	372521	111031	50120420
Multiple organ dysfunction syndrome	56.28	9.96	187	373486	50150	50181301
Diabetic ketoacidosis	56.08	9.96	31	373642	17841	50213610
Blood glucose increased	55.67	9.96	304	373369	71020	50160431
Fluid retention	54.03	9.96	192	373481	50457	50180994
Blood pressure diastolic abnormal	53.93	9.96	172	373501	9189	50222262
Hallucination	53.78	9.96	171	373502	46486	50184965
Muscle spasticity	53.64	9.96	30	373643	17154	50214297
Injection site swelling	53.45	9.96	507	373166	41266	50190185
Injection site reaction	53.38	9.96	585	373088	49447	50182004
Osteoporosis	53.18	9.96	536	373137	44343	50187108
Altered state of consciousness	53.09	9.96	50	373623	21860	50209591
Peripheral swelling	52.89	9.96	1938	371735	203998	50027453
Cholestasis	52.65	9.96	66	373607	25335	50206116
Sedation complication	52.52	9.96	3	373670	8763	50222688
Blood cholesterol increased	52.36	9.96	631	373042	54584	50176867
Pulmonary embolism	52.29	9.96	489	373184	101215	50130236
Fibromyalgia	52.25	9.96	535	373138	44443	50187008
Injection site pain	52.23	9.96	1129	372544	109895	50121556
Seizure	51.88	9.96	588	373085	117286	50114165
Orthostatic hypotension	51.84	9.96	86	373587	29395	50202056
Respiratory disorder	51.19	9.96	95	373578	31092	50200359
Disturbance in attention	51.19	9.96	95	373578	31091	50200360
Mental status changes	50.72	9.96	121	373552	36151	50195300
Foetal exposure during pregnancy	50.62	9.96	361	373312	26998	50204453
Vision blurred	50.59	9.96	356	373317	78291	50153160
Type 2 diabetes mellitus	50.01	9.96	429	373244	33946	50197505
Dehydration	49.90	9.96	808	372865	151641	50079810
Cytomegalovirus infection	49.70	9.96	36	373637	17926	50213525
Grip strength decreased	49.53	9.96	199	373474	11922	50219529
Chest discomfort	49.32	9.96	442	373231	92280	50139171
Hypokalaemia	49.22	9.96	414	373259	87578	50143873
Bone erosion	48.66	9.96	193	373480	11494	50219957
Loss of personal independence in daily activities	48.62	9.96	757	372916	69293	50162158
Emotional distress	48.22	9.96	86	373587	28577	50202874
Hepatocellular injury	48.17	9.96	73	373600	25874	50205577
Premature labour	48.17	9.96	190	373483	11286	50220165
Mydriasis	47.88	9.96	10	373663	10617	50220834
Restlessness	47.54	9.96	70	373603	25103	50206348
Metastases to bone	47.32	9.96	38	373635	17957	50213494
Blood pressure systolic increased	47.24	9.96	434	373239	35015	50196436
Neutrophil count decreased	46.77	9.96	178	373495	45848	50185603
Ejection fraction decreased	46.38	9.96	41	373632	18479	50212972
Pulmonary arterial hypertension	46.22	9.96	49	373624	20270	50211181
Depression	45.83	9.96	903	372770	164520	50066931
Blood pressure systolic abnormal	45.69	9.96	143	373530	7563	50223888
Gestational diabetes	45.62	9.96	140	373533	7325	50224126
Decreased appetite	45.59	9.96	1132	372541	199791	50031660
Anaphylactic reaction	44.64	9.96	226	373447	53829	50177622
Loss of consciousness	44.57	9.96	524	373149	103829	50127622
Poisoning	44.46	9.96	18	373655	12411	50219040
Hyperkalaemia	44.46	9.96	193	373480	47896	50183555
White blood cell count decreased	44.30	9.96	601	373072	116121	50115330
Dyspnoea exertional	44.15	9.96	211	373462	51022	50180429
Product use in unapproved indication	44.08	9.96	596	373077	115223	50116228
Delirium	44.00	9.96	140	373533	38052	50193399
Infection	43.99	9.96	1626	372047	171328	50060123
Neck deformity	43.70	9.96	63	373610	1915	50229536
Product administration error	43.16	9.96	49	373624	19650	50211801
Hospitalisation	42.97	9.96	309	373364	67628	50163823
Osteonecrosis of jaw	42.76	9.96	112	373561	32414	50199037
Speech disorder	42.59	9.96	128	373545	35420	50196031
Shock	42.44	9.96	54	373619	20596	50210855
Tuberculosis	42.37	9.96	167	373506	9916	50221535
Weight increased	42.32	9.96	1859	371814	200032	50031419
Multiple fractures	42.30	9.96	126	373547	6485	50224966
Hypothermia	42.02	9.96	18	373655	11998	50219453
Respiratory depression	41.99	9.96	18	373655	11992	50219459
Maternal drugs affecting foetus	41.67	9.96	106	373567	4971	50226480
Disorientation	41.63	9.96	129	373544	35355	50196096
Suicidal ideation	41.62	9.96	239	373434	55146	50176305
Rheumatoid nodule	41.27	9.96	195	373478	12540	50218911
Extrapyramidal disorder	40.58	9.96	18	373655	11752	50219699
Leukopenia	40.39	9.96	312	373361	67216	50164235
Memory impairment	40.17	9.96	383	373290	78977	50152474
Acute hepatic failure	40.11	9.96	34	373639	15643	50215808
Myocardial infarction	39.99	9.96	442	373231	88585	50142866
Creatinine renal clearance decreased	39.67	9.96	19	373654	11862	50219589
Blood pressure decreased	39.52	9.96	246	373427	55663	50175788
Blood creatine phosphokinase increased	39.27	9.96	85	373588	26282	50205169
Gamma-glutamyltransferase increased	38.18	9.96	103	373570	29520	50201931
Angioedema	38.09	9.96	146	373527	37530	50193921
Drug level increased	37.95	9.96	52	373621	19216	50212235
Abnormal behaviour	37.77	9.96	54	373619	19604	50211847
Unresponsive to stimuli	37.55	9.96	109	373564	30500	50200951
Ascites	37.54	9.96	137	373536	35724	50195727
Posterior reversible encephalopathy syndrome	37.44	9.96	33	373640	14895	50216556
Pre-eclampsia	36.90	9.96	137	373536	7907	50223544
Pain in jaw	36.90	9.96	152	373521	38276	50193175
Joint stiffness	36.88	9.96	364	373309	29944	50201507
Enthesopathy	36.83	9.96	127	373546	7066	50224385
Blood pressure diastolic decreased	36.80	9.96	231	373442	16550	50214901
Deep vein thrombosis	36.58	9.96	355	373318	72949	50158502
Localised infection	36.52	9.96	317	373356	25168	50206283
Polyarthritis	36.36	9.96	135	373538	7792	50223659
Platelet count decreased	36.31	9.96	524	373149	100202	50131249
Blood alkaline phosphatase increased	36.30	9.96	148	373525	37378	50194073
Accidental overdose	36.22	9.96	55	373618	19478	50211973
Intentional product use issue	36.10	9.96	782	372891	76136	50155315
Disseminated intravascular coagulation	36.06	9.96	44	373629	17091	50214360
Metastases to liver	35.95	9.96	58	373615	20046	50211405
Ventricular septal defect	35.94	9.96	87	373586	3954	50227497
Blood bilirubin increased	35.82	9.96	119	373554	31919	50199532
Cerebral haemorrhage	35.67	9.96	93	373580	26959	50204492
Dysgeusia	35.48	9.96	157	373516	38759	50192692
Nodule	35.41	9.96	231	373442	16772	50214679
Bone pain	35.38	9.96	204	373469	47025	50184426
Maternal exposure before pregnancy	35.17	9.96	106	373567	5491	50225960
Vertigo	35.13	9.96	231	373442	51601	50179850
Dysarthria	34.64	9.96	150	373523	37253	50194198
Flushing	34.52	9.96	322	373351	66693	50164758
Infective pulmonary exacerbation of cystic fibrosis	34.50	9.96	8	373665	7901	50223550
Injection site rash	34.44	9.96	221	373452	15956	50215495
Palpitations	34.29	9.96	491	373182	94015	50137436
Blood calcium decreased	34.05	9.96	63	373610	20643	50210808
Brain oedema	33.95	9.96	25	373648	12345	50219106
Aspartate aminotransferase increased	33.94	9.96	390	373283	77608	50153843
Limb deformity	33.87	9.96	81	373592	3653	50227798
Arrhythmia	33.75	9.96	128	373545	33004	50198447
Torsade de pointes	33.69	9.96	23	373650	11812	50219639
C-reactive protein increased	33.53	9.96	683	372990	65791	50165660
Pulmonary fibrosis	33.48	9.96	301	373372	24136	50207315
Injection site bruising	33.47	9.96	417	373256	36351	50195100
Joint destruction	33.44	9.96	83	373590	3833	50227618
Device dislocation	33.31	9.96	68	373605	21478	50209973
Tenderness	33.21	9.96	243	373430	18322	50213129
Dysphagia	33.19	9.96	389	373284	77129	50154322
Chronic kidney disease	33.00	9.96	166	373507	39605	50191846
Inflammation	32.88	9.96	597	373076	56315	50175136
Haemorrhage	32.87	9.96	245	373428	53196	50178255
Premature delivery	32.69	9.96	292	373381	23371	50208080
Musculoskeletal pain	32.35	9.96	729	372944	71448	50160003
Drug ineffective for unapproved indication	32.19	9.96	68	373605	21213	50210238
Disability	31.95	9.96	182	373491	12593	50218858
Premature rupture of membranes	31.91	9.96	90	373583	4490	50226961
Small for dates baby	31.75	9.96	76	373597	3429	50228022
Anaphylactic shock	31.68	9.96	63	373610	20092	50211359
Femur fracture	31.62	9.96	419	373254	37045	50194406
Nightmare	31.09	9.96	44	373629	16042	50215409
Alanine aminotransferase increased	31.03	9.96	462	373211	87897	50143554
Akathisia	30.97	9.96	11	373662	8218	50223233
Chest pain	30.88	9.96	1033	372640	175849	50055602
Ventricular fibrillation	30.76	9.96	20	373653	10539	50220912
Diabetes mellitus inadequate control	30.69	9.96	31	373642	13114	50218337
Wrong technique in product usage process	30.66	9.96	262	373411	55248	50176203
Tenosynovitis stenosans	30.36	9.96	57	373616	2167	50229284
Heart rate decreased	30.31	9.96	407	373266	36090	50195361
Cytokine release syndrome	30.09	9.96	13	373660	8621	50222830
Pleural effusion	29.97	9.96	422	373251	81032	50150419
Neuroleptic malignant syndrome	29.90	9.96	23	373650	11107	50220344
Ventricular tachycardia	29.87	9.96	44	373629	15777	50215674
Respiratory distress	29.64	9.96	120	373553	30369	50201082
Joint range of motion decreased	29.58	9.96	236	373437	18276	50213175
Inappropriate antidiuretic hormone secretion	29.55	9.96	32	373641	13111	50218340
Withdrawal syndrome	29.39	9.96	53	373620	17537	50213914
Pulmonary oedema	28.85	9.96	227	373446	48711	50182740
Neurotoxicity	28.81	9.96	40	373633	14700	50216751
Smear cervix abnormal	28.78	9.96	63	373610	2678	50228773
Psychotic disorder	28.75	9.96	75	373598	21737	50209714
Synovial cyst	28.65	9.96	128	373545	8038	50223413
Acute respiratory failure	28.16	9.96	113	373560	28669	50202782
Tenosynovitis	28.08	9.96	153	373520	10412	50221039
Toxic skin eruption	28.06	9.96	25	373648	11226	50220225
Hypomagnesaemia	28.01	9.96	83	373590	23073	50208378
International normalised ratio increased	27.90	9.96	195	373478	42957	50188494
Blood pressure diastolic increased	27.90	9.96	119	373554	7324	50224127
Atrial fibrillation	27.67	9.96	557	373116	101188	50130263
Schizophrenia	27.65	9.96	10	373663	7387	50224064
Latent tuberculosis	27.58	9.96	55	373618	2188	50229263
Dyskinesia	27.50	9.96	109	373564	27752	50203699
Immune reconstitution inflammatory syndrome	27.45	9.96	4	373669	5512	50225939
Coagulopathy	27.43	9.96	57	373616	17887	50213564
Cerebrovascular accident	27.37	9.96	513	373160	94167	50137284
Device difficult to use	27.11	9.96	20	373653	9866	50221585
Gastrointestinal haemorrhage	26.92	9.96	380	373293	72941	50158510
Blood creatinine increased	26.82	9.96	398	373275	75762	50155689
Laryngitis	26.69	9.96	155	373518	10801	50220650
Wheelchair user	26.53	9.96	89	373584	4883	50226568
Dysmorphism	26.48	9.96	53	373620	2114	50229337
Irritability	26.32	9.96	114	373559	28312	50203139
Pulmonary hypertension	26.31	9.96	142	373531	33275	50198176
Eosinophilia	26.25	9.96	62	373611	18590	50212861
Melaena	25.95	9.96	106	373567	26758	50204693
Drug tolerance decreased	25.94	9.96	135	373538	9025	50222426
Metastases to central nervous system	25.89	9.96	27	373646	11255	50220196
Skin ulcer	25.78	9.96	385	373288	34933	50196518
Polyneuropathy	25.69	9.96	31	373642	12100	50219351
Arthritis infective	25.67	9.96	95	373578	5474	50225977
Crying	25.56	9.96	72	373601	20344	50211107
Skin papilloma	25.56	9.96	79	373594	4150	50227301
Bronchospasm	25.50	9.96	44	373629	14810	50216641
Parkinsonism	25.45	9.96	17	373656	8830	50222621
Obstructive airways disorder	25.40	9.96	48	373625	15604	50215847
Bradyphrenia	25.34	9.96	7	373666	6145	50225306
Malignant melanoma	25.28	9.96	144	373529	9964	50221487
Macular degeneration	25.27	9.96	42	373631	14346	50217105
Mania	25.19	9.96	26	373647	10890	50220561
Atrioventricular block complete	25.16	9.96	11	373662	7244	50224207
Ischaemic stroke	24.94	9.96	50	373623	15898	50215553
Pain in extremity	24.92	9.96	2339	371334	270526	49960925
Asphyxia	24.67	9.96	5	373668	5422	50226029
Back pain	24.57	9.96	1351	372322	218679	50012772
Jaundice	24.47	9.96	106	373567	26323	50205128
Transplant rejection	24.39	9.96	21	373652	9588	50221863
Neck mass	24.36	9.96	67	373606	3294	50228157
Stress cardiomyopathy	24.28	9.96	14	373659	7873	50223578
Oedema peripheral	24.27	9.96	937	372736	157024	50074427
Developmental hip dysplasia	24.08	9.96	38	373635	1253	50230198
Placental disorder	23.84	9.96	40	373633	1390	50230061
Thrombotic microangiopathy	23.83	9.96	18	373655	8773	50222678
Face oedema	23.77	9.96	61	373612	17778	50213673
Sepsis	23.73	9.96	774	372899	132151	50099300
Synovial fluid analysis	23.64	9.96	43	373630	1595	50229856
Device use error	23.63	9.96	5	373668	5261	50226190
Acute generalised exanthematous pustulosis	23.34	9.96	19	373654	8919	50222532
Abdominal distension	23.30	9.96	388	373285	72515	50158936
Fear	23.28	9.96	45	373628	14504	50216947
Aggression	23.22	9.96	79	373594	21037	50210414
Second primary malignancy	23.17	9.96	11	373662	6903	50224548
Paralysis	23.15	9.96	18	373655	8646	50222805
Tumour lysis syndrome	23.10	9.96	13	373660	7408	50224043
Hypomania	23.05	9.96	3	373670	4502	50226949
Pancreatitis acute	22.97	9.96	94	373579	23718	50207733
Myoclonus	22.94	9.96	45	373628	14425	50217026
Haematotoxicity	22.94	9.96	15	373658	7880	50223571
Spinal stenosis	22.90	9.96	175	373498	13375	50218076
Oropharyngeal pain	22.90	9.96	744	372929	77057	50154394
Febrile bone marrow aplasia	22.80	9.96	9	373664	6302	50225149
Blood potassium decreased	22.42	9.96	170	373503	36775	50194676
Product adhesion issue	22.29	9.96	3	373670	4389	50227062
Stomatitis	22.28	9.96	938	372735	100406	50131045
Accidental exposure to product	22.26	9.96	91	373582	22966	50208485
Rotator cuff repair	22.21	9.96	43	373630	1673	50229778
Acute myeloid leukaemia	22.11	9.96	49	373624	15025	50216426
Hypervolaemia	21.98	9.96	105	373568	25394	50206057
Graft versus host disease	21.94	9.96	9	373664	6157	50225294
Loose body in joint	21.88	9.96	35	373638	1168	50230283
Depressed mood	21.87	9.96	154	373519	33869	50197582
Muscular weakness	21.87	9.96	534	373139	94479	50136972
Pyrexia	21.82	9.96	2466	371207	377737	49853714
Polyhydramnios	21.78	9.96	47	373626	1978	50229473
Dystonia	21.71	9.96	34	373639	11892	50219559
Agranulocytosis	21.66	9.96	83	373590	21338	50210113
Abdominal pain	21.55	9.96	1478	372195	234750	49996701
Panic attack	21.51	9.96	72	373601	19270	50212181
Pulmonary tuberculosis	21.49	9.96	75	373598	4198	50227253
Product dose omission issue	21.41	9.96	1124	372549	182714	50048737
Hemiparesis	21.37	9.96	76	373597	19972	50211479
Postoperative wound infection	21.37	9.96	121	373552	8354	50223097
Miosis	21.21	9.96	10	373663	6300	50225151
Complication of device insertion	21.20	9.96	9	373664	6032	50225419
Therapeutic response decreased	21.15	9.96	477	373196	46754	50184697
Cardiac failure acute	20.98	9.96	18	373655	8232	50223219
Unevaluable event	20.96	9.96	228	373445	45838	50185613
Tardive dyskinesia	20.92	9.96	14	373659	7265	50224186
Gastroenteritis viral	20.65	9.96	221	373452	18565	50212886
Pancreatitis	20.58	9.96	208	373465	42406	50189045
Anhedonia	20.53	9.96	24	373649	9500	50221951
Substance abuse	20.50	9.96	3	373670	4121	50227330
Confusional state	20.50	9.96	1143	372530	184785	50046666
Body temperature decreased	20.48	9.96	198	373475	16197	50215254
Atrial septal defect	20.48	9.96	97	373576	6244	50225207
Lethargy	20.41	9.96	250	373423	49182	50182269
Uterine perforation	20.31	9.96	11	373662	6404	50225047
Cardiogenic shock	20.28	9.96	54	373619	15545	50215906
Cytopenia	20.14	9.96	21	373652	8754	50222697
Joint dislocation	20.13	9.96	158	373515	12175	50219276
Tachypnoea	20.08	9.96	49	373624	14528	50216923
COVID-19	20.03	9.96	234	373439	46428	50185023
Rash maculo-papular	19.99	9.96	115	373558	26526	50204925
Herpes zoster	19.83	9.96	673	373000	70113	50161338
Genital haemorrhage	19.77	9.96	12	373661	6562	50224889
Complication associated with device	19.61	9.96	50	373623	14605	50216846
Dementia	19.59	9.96	57	373616	15940	50215511
Body height below normal	19.57	9.96	44	373629	1905	50229546
Disease recurrence	19.54	9.96	79	373594	20002	50211449
Glycosylated haemoglobin increased	19.53	9.96	30	373643	10576	50220875
Hyperlipidaemia	19.53	9.96	65	373608	17425	50214026
Metastases to lung	19.51	9.96	32	373641	10988	50220463
Foetal death	19.46	9.96	115	373558	8065	50223386
Psychomotor hyperactivity	19.45	9.96	24	373649	9277	50222174
Acute graft versus host disease	19.40	9.96	3	373670	3955	50227496
Nervousness	19.36	9.96	122	373551	27529	50203922
Erythema multiforme	19.30	9.96	23	373650	9027	50222424
Acute chest syndrome	19.22	9.96	24	373649	633	50230818
Haemorrhage intracranial	19.17	9.96	39	373634	12335	50219116
Urinary retention	19.15	9.96	114	373559	26076	50205375
Injection site warmth	19.10	9.96	171	373502	13695	50217756
Stevens-Johnson syndrome	19.08	9.96	89	373584	21663	50209788
Red blood cell sedimentation rate	18.96	9.96	64	373609	3522	50227929
Headache	18.94	9.96	3372	370301	503163	49728288
Pemphigoid	18.89	9.96	10	373663	5897	50225554
Maternal exposure timing unspecified	18.61	9.96	64	373609	3556	50227895
Plasma cell myeloma	18.59	9.96	145	373528	31177	50200274
Foetal anticonvulsant syndrome	18.53	9.96	22	373651	550	50230901
Status epilepticus	18.52	9.96	45	373628	13361	50218090
Joint injury	18.51	9.96	244	373429	21545	50209906
Sinus tachycardia	18.36	9.96	88	373585	21266	50210185
Haemophagocytic lymphohistiocytosis	18.34	9.96	22	373651	8611	50222840
Subdural haematoma	18.25	9.96	43	373630	12904	50218547
Congenital arterial malformation	18.16	9.96	17	373656	320	50231131
Antinuclear antibody positive	18.15	9.96	93	373580	6179	50225272
Cholecystitis chronic	18.14	9.96	27	373646	9642	50221809
Joint noise	18.08	9.96	63	373610	3524	50227927
Fear of injection	18.02	9.96	91	373582	6012	50225439
Shock haemorrhagic	18.01	9.96	21	373652	8323	50223128
Crohn's disease	17.99	9.96	76	373597	4657	50226794
Oral herpes	17.99	9.96	233	373440	20492	50210959
Atrioventricular block	17.90	9.96	13	373660	6465	50224986
Clear cell renal cell carcinoma	17.90	9.96	32	373641	1171	50230280
Infusion site erythema	17.75	9.96	23	373650	8704	50222747
Leukocytosis	17.74	9.96	96	373577	22483	50208968
Haemorrhage in pregnancy	17.63	9.96	39	373634	1670	50229781
Dactylitis	17.56	9.96	41	373632	1820	50229631
Mood altered	17.55	9.96	43	373630	12730	50218721
Device related infection	17.51	9.96	86	373587	20649	50210802
Cushingoid	17.50	9.96	96	373577	6549	50224902
Synovial disorder	17.50	9.96	27	373646	873	50230578
Gestational hypertension	17.45	9.96	45	373628	2128	50229323
Scleritis	17.43	9.96	58	373615	3169	50228282
Exposure to toxic agent	17.42	9.96	3	373670	3655	50227796
Lupus-like syndrome	17.42	9.96	125	373548	9366	50222085
Infusion site pain	17.41	9.96	41	373632	12305	50219146
Skin cancer	17.40	9.96	124	373549	9270	50222181
Paradoxical drug reaction	17.35	9.96	3	373670	3644	50227807
Hallucination, auditory	17.32	9.96	33	373640	10695	50220756
Breast feeding	17.28	9.96	26	373647	822	50230629
Salivary hypersecretion	17.23	9.96	14	373659	6577	50224874
Incorrect route of product administration	17.20	9.96	75	373598	18591	50212860
Myocarditis	17.16	9.96	20	373653	7927	50223524
Labelled drug-drug interaction medication error	17.12	9.96	32	373641	10445	50221006
Hypertransaminasaemia	17.11	9.96	3	373670	3608	50227843
Stillbirth	17.05	9.96	88	373585	5864	50225587
Proteinuria	16.98	9.96	64	373609	16533	50214918
Lymphocyte count decreased	16.95	9.96	119	373554	26188	50205263
Acidosis	16.92	9.96	31	373642	10196	50221255
Ketoacidosis	16.87	9.96	4	373669	3891	50227560
Haematoma	16.85	9.96	144	373529	30366	50201085
Myopathy	16.69	9.96	26	373647	9113	50222338
Fracture	16.67	9.96	194	373479	16639	50214812
Complication of device removal	16.67	9.96	5	373668	4159	50227292
Talipes	16.58	9.96	34	373639	1380	50230071
Clostridium difficile colitis	16.52	9.96	71	373602	17671	50213780
Dry skin	16.51	9.96	222	373451	42969	50188482
Multiple allergies	16.50	9.96	23	373650	8440	50223011
Aphasia	16.41	9.96	133	373540	28361	50203090
Sleep apnoea syndrome	16.36	9.96	106	373567	23762	50207689
Haemoptysis	16.32	9.96	116	373557	25457	50205994
Hypophosphataemia	16.28	9.96	23	373650	8391	50223060
Dislocation of vertebra	16.24	9.96	55	373618	3032	50228419
Hepatotoxicity	16.18	9.96	126	373547	27100	50204351
Fracture delayed union	16.13	9.96	45	373628	2231	50229220
Immunodeficiency	16.10	9.96	174	373499	14654	50216797
Cardiomyopathy	16.01	9.96	60	373613	15526	50215925
Oedema	15.99	9.96	395	373278	69786	50161665
Tubulointerstitial nephritis	15.99	9.96	58	373615	15153	50216298
Off label use	15.93	9.96	3176	370497	471250	49760201
Wheezing	15.88	9.96	343	373330	61704	50169747
Mouth ulceration	15.84	9.96	293	373380	27731	50203720
Skin exfoliation	15.84	9.96	165	373508	33447	50198004
Respiration abnormal	15.79	9.96	9	373664	5093	50226358
Hypophagia	15.70	9.96	130	373543	27598	50203853
Hallucination, visual	15.66	9.96	66	373607	16516	50214935
Multiple sclerosis	15.63	9.96	88	373585	20405	50211046
Injection site haematoma	15.59	9.96	87	373586	5973	50225478
Pharyngitis streptococcal	15.59	9.96	115	373558	8693	50222758
Hyperprolactinaemia	15.51	9.96	3	373670	3362	50228089
Neonatal respiratory distress syndrome	15.50	9.96	49	373624	2605	50228846
Muscle twitching	15.47	9.96	60	373613	15371	50216080
Catheter site erythema	15.42	9.96	5	373668	3957	50227494
Bone marrow failure	15.42	9.96	130	373543	27494	50203957
Human antichimeric antibody positive	15.38	9.96	34	373639	1455	50229996
Generalised oedema	15.35	9.96	51	373622	13680	50217771
Diabetes mellitus	15.33	9.96	262	373411	48771	50182680
Temperature regulation disorder	15.32	9.96	6	373667	4221	50227230
Cerebral infarction	15.29	9.96	95	373578	21509	50209942
Angina pectoris	15.19	9.96	122	373551	26066	50205385
Poor venous access	15.01	9.96	129	373544	10211	50221240
Delusion	14.98	9.96	35	373638	10534	50220917
Pathogen resistance	14.97	9.96	12	373661	5677	50225774
Aspergillus infection	14.90	9.96	17	373656	6804	50224647
Rash erythematous	14.87	9.96	175	373498	34677	50196774
Affective disorder	14.84	9.96	10	373663	5171	50226280
Pulmonary congestion	14.83	9.96	60	373613	15187	50216264
Antibody test positive	14.74	9.96	44	373629	2267	50229184
Vascular device infection	14.65	9.96	7	373666	4377	50227074
Blood glucose decreased	14.55	9.96	77	373596	18134	50213317
Aspiration	14.52	9.96	29	373644	9235	50222216
Colitis microscopic	14.52	9.96	16	373657	6504	50224947
Infusion site swelling	14.50	9.96	19	373654	7157	50224294
Speech disorder developmental	14.45	9.96	20	373653	585	50230866
Gastrointestinal disorder	14.44	9.96	844	372829	93612	50137839
Bronchopulmonary aspergillosis	14.44	9.96	21	373652	7571	50223880
Oliguria	14.41	9.96	24	373649	8192	50223259
Muscle rigidity	14.38	9.96	32	373641	9797	50221654
Pseudomonas infection	14.37	9.96	30	373643	9400	50222051
Bone disorder	14.31	9.96	206	373467	18546	50212905
Exomphalos	14.30	9.96	19	373654	534	50230917
Squamous cell carcinoma	14.24	9.96	102	373571	7637	50223814
Polyuria	14.24	9.96	19	373654	7102	50224349
Cholestasis of pregnancy	14.23	9.96	28	373645	1103	50230348
Catheter site pain	14.21	9.96	5	373668	3757	50227694
Bundle branch block left	14.19	9.96	15	373658	6215	50225236
Malaise	14.19	9.96	2218	371455	333314	49898137
Tendonitis	14.16	9.96	187	373486	16518	50214933
Surgery	14.14	9.96	307	373366	29898	50201553
Device breakage	14.03	9.96	31	373642	9516	50221935
Pericardial effusion	14.03	9.96	121	373552	25468	50205983
Lip swelling	14.00	9.96	116	373557	24620	50206831
Toxic epidermal necrolysis	14.00	9.96	94	373579	20898	50210553
Cyanosis	13.99	9.96	61	373612	15123	50216328
Right ventricular failure	13.96	9.96	65	373608	15828	50215623
Product prescribing error	13.91	9.96	94	373579	20867	50210584
Blood iron increased	13.86	9.96	31	373642	1337	50230114
Joint lock	13.83	9.96	40	373633	2025	50229426
Anuria	13.82	9.96	40	373633	11204	50220247
Immunosuppression	13.74	9.96	98	373575	7328	50224123
Influenza	13.68	9.96	800	372873	88738	50142713
Autism spectrum disorder	13.54	9.96	21	373652	682	50230769
Foetal distress syndrome	13.51	9.96	29	373644	1216	50230235
Renal injury	13.46	9.96	27	373646	8584	50222867
Hypertelorism	13.45	9.96	16	373657	401	50231050
Anger	13.43	9.96	41	373632	11292	50220159
Dysuria	13.40	9.96	140	373533	28364	50203087
Sinus bradycardia	13.38	9.96	51	373622	13132	50218319
Abdominal pain upper	13.33	9.96	1004	372669	158305	50073146
Bundle branch block right	13.26	9.96	9	373664	4636	50226815
Induced labour	13.20	9.96	24	373649	890	50230561
Coronary artery disease	13.17	9.96	148	373525	29578	50201873
Hot flush	13.17	9.96	238	373435	43931	50187520
Urinary incontinence	13.08	9.96	139	373534	28069	50203382
Cervical incompetence	13.05	9.96	19	373654	583	50230868
Hallucinations, mixed	13.04	9.96	7	373666	4096	50227355
Tumour marker increased	13.04	9.96	6	373667	3834	50227617
Visual acuity reduced	13.02	9.96	91	373582	20048	50211403
Hepatic cytolysis	13.02	9.96	25	373648	8078	50223373
Colitis	12.99	9.96	203	373470	38326	50193125
Occult blood	12.97	9.96	28	373645	1179	50230272
Mental disorder	12.96	9.96	102	373571	21889	50209562
Ankylosing spondylitis	12.94	9.96	94	373579	7071	50224380
Wound infection	12.93	9.96	142	373531	12006	50219445
Tongue disorder	12.87	9.96	114	373559	9102	50222349
Personality disorder	12.86	9.96	8	373665	4316	50227135
Ulcer	12.77	9.96	215	373458	19985	50211466
Arthritis bacterial	12.66	9.96	78	373595	5551	50225900
Myelosuppression	12.64	9.96	54	373619	13463	50217988
Product substitution issue	12.64	9.96	57	373616	14000	50217451
Klebsiella infection	12.63	9.96	21	373652	7173	50224278
Joint warmth	12.60	9.96	30	373643	1349	50230102
Therapy change	12.57	9.96	12	373661	5213	50226238
Visual impairment	12.55	9.96	396	373277	67879	50163572
Lymphatic fistula	12.53	9.96	21	373652	729	50230722
Hereditary angioedema	12.51	9.96	13	373660	5429	50226022
Malignant mediastinal neoplasm	12.51	9.96	18	373655	546	50230905
Hyperthyroidism	12.42	9.96	47	373626	12128	50219323
Foot fracture	12.40	9.96	213	373460	19878	50211573
Paraesthesia	12.37	9.96	744	372929	119499	50111952
Purpura	12.37	9.96	35	373638	9876	50221575
Femoral hernia incarcerated	12.30	9.96	21	373652	740	50230711
Serum ferritin increased	12.29	9.96	73	373600	5129	50226322
Injection site irritation	12.24	9.96	64	373609	4286	50227165
Human anti-human antibody test	12.18	9.96	15	373658	390	50231061
Transplant dysfunction	12.18	9.96	10	373663	4674	50226777
Maternal exposure during breast feeding	12.17	9.96	52	373621	3202	50228249
Dermatitis exfoliative	12.15	9.96	12	373661	5130	50226321
Respiratory acidosis	12.14	9.96	16	373657	6012	50225439
Tendon disorder	12.13	9.96	74	373599	5248	50226203
Infusion site pruritus	12.11	9.96	7	373666	3930	50227521
Cardiac disorder	12.07	9.96	234	373439	42745	50188706
Drug abuser	12.06	9.96	3	373670	2825	50228626
Polydipsia	12.06	9.96	4	373669	3120	50228331
Acute pulmonary oedema	12.05	9.96	22	373651	7245	50224206
Patent ductus arteriosus	12.02	9.96	58	373615	3762	50227689
Trigeminal neuralgia	12.01	9.96	4	373669	3111	50228340
Pulseless electrical activity	11.99	9.96	20	373653	6821	50224630
Wound infection pseudomonas	11.96	9.96	28	373645	1245	50230206
Endodontic procedure	11.96	9.96	46	373627	2700	50228751
Pneumonia viral	11.95	9.96	20	373653	6814	50224637
Pancytopenia	11.94	9.96	746	372927	83284	50148167
Treatment noncompliance	11.88	9.96	154	373519	29996	50201455
Bronchitis	11.87	9.96	908	372765	103251	50128200
Product complaint	11.87	9.96	44	373629	11422	50220029
Abortion missed	11.85	9.96	32	373641	1556	50229895
Eating disorder	11.84	9.96	66	373607	15343	50216108
Product preparation error	11.79	9.96	9	373664	4363	50227088
Renal disorder	11.78	9.96	138	373535	27367	50204084
Epstein-Barr virus infection	11.76	9.96	21	373652	6976	50224475
Swollen tongue	11.74	9.96	145	373528	28485	50202966
Acute myocardial infarction	11.73	9.96	149	373524	29124	50202327
Systemic inflammatory response syndrome	11.68	9.96	12	373661	5037	50226414
Bone density abnormal	11.66	9.96	49	373624	2996	50228455
Drug-induced liver injury	11.63	9.96	142	373531	27953	50203498
Abortion threatened	11.57	9.96	17	373656	526	50230925
Lymphoedema	11.54	9.96	32	373641	9090	50222361
Multiple-drug resistance	11.53	9.96	5	373668	3309	50228142
Pregnancy with contraceptive device	11.51	9.96	8	373665	4071	50227380
Blood loss anaemia	11.50	9.96	27	373646	8112	50223339
Food allergy	11.49	9.96	27	373646	8110	50223341
Potentiating drug interaction	11.43	9.96	7	373666	3809	50227642
Ingrown hair	11.43	9.96	16	373657	473	50230978
Sexual dysfunction	11.40	9.96	5	373668	3287	50228164
Amylase increased	11.37	9.96	14	373659	5416	50226035
Pulmonary haemorrhage	11.36	9.96	19	373654	6473	50224978
Rheumatoid lung	11.32	9.96	42	373631	2423	50229028
Anterior chamber cleavage syndrome	11.32	9.96	10	373663	174	50231277
Learning disorder	11.27	9.96	18	373655	600	50230851
Knee operation	11.26	9.96	68	373605	4805	50226646
Crystal nephropathy	11.26	9.96	21	373652	794	50230657
Circulatory collapse	11.22	9.96	94	373579	19906	50211545
Renal tubular necrosis	11.21	9.96	38	373635	10130	50221321
Progressive multifocal leukoencephalopathy	11.20	9.96	45	373628	11412	50220039
Paranoia	11.18	9.96	39	373634	10309	50221142
Bone lesion	11.17	9.96	13	373660	5157	50226294
Intervertebral disc degeneration	11.13	9.96	150	373523	13311	50218140
Lung adenocarcinoma	11.07	9.96	60	373613	4074	50227377
Affect lability	11.07	9.96	32	373641	8966	50222485
Abnormal dreams	11.06	9.96	34	373639	9343	50222108
Somnambulism	11.06	9.96	12	373661	4912	50226539
Cardiotoxicity	11.01	9.96	22	373651	7005	50224446
Adverse event	11.00	9.96	411	373262	43352	50188099
Plasma cell myeloma recurrent	10.99	9.96	3	373670	2655	50228796
Catatonia	10.99	9.96	7	373666	3729	50227722
Nystagmus	10.96	9.96	15	373658	5546	50225905
Alanine aminotransferase abnormal	10.92	9.96	60	373613	4096	50227355
Presyncope	10.91	9.96	120	373553	24078	50207373
Forceps delivery	10.91	9.96	10	373663	183	50231268
Peripheral sensory neuropathy	10.88	9.96	20	373653	6571	50224880
Myofascial pain syndrome	10.86	9.96	37	373636	2046	50229405
Coronary arterial stent insertion	10.84	9.96	3	373670	2631	50228820
Haemodialysis	10.83	9.96	29	373644	8333	50223118
Product administered to patient of inappropriate age	10.82	9.96	3	373670	2627	50228824
Inflammatory marker increased	10.80	9.96	75	373598	5559	50225892
Bradykinesia	10.78	9.96	8	373665	3935	50227516
Placental insufficiency	10.78	9.96	27	373646	1254	50230197
Hepatitis acute	10.78	9.96	27	373646	7934	50223517
Carpal tunnel syndrome	10.76	9.96	180	373493	16713	50214738
Toxic encephalopathy	10.74	9.96	15	373658	5500	50225951
Chondropathy	10.68	9.96	37	373636	2063	50229388
Pleuritic pain	10.64	9.96	83	373590	6383	50225068
Stress at work	10.64	9.96	24	373649	1041	50230410
Troponin increased	10.63	9.96	28	373645	8090	50223361
Lymphadenectomy	10.58	9.96	22	373651	902	50230549
Nail injury	10.58	9.96	15	373658	449	50231002
Threatened labour	10.53	9.96	20	373653	767	50230684
Drug screen positive	10.53	9.96	6	373667	3396	50228055
Pancreatic steatosis	10.50	9.96	22	373651	907	50230544
Head injury	10.48	9.96	120	373553	23900	50207551
Ankyloglossia congenital	10.44	9.96	10	373663	194	50231257
Abortion incomplete	10.44	9.96	5	373668	3121	50228330
Eosinophil count increased	10.43	9.96	32	373641	8798	50222653
Haematocrit decreased	10.42	9.96	335	373338	34641	50196810
Vacuum extractor delivery	10.41	9.96	9	373664	152	50231299
Inadequate analgesia	10.37	9.96	3	373670	2555	50228896
Product physical issue	10.36	9.96	10	373663	4322	50227129
Congenital hydronephrosis	10.36	9.96	14	373659	400	50231051
Acute coronary syndrome	10.35	9.96	35	373638	9339	50222112
Chills	10.35	9.96	596	373077	96091	50135360
Embedded device	10.33	9.96	4	373669	2833	50228618
Retinitis	10.26	9.96	34	373639	1853	50229598
Lung transplant	10.25	9.96	4	373669	2821	50228630
Restless legs syndrome	10.20	9.96	72	373601	15825	50215626
Retrognathia	10.10	9.96	14	373659	410	50231041
Ileus paralytic	10.10	9.96	9	373664	4041	50227410
Ataxia	10.08	9.96	60	373613	13726	50217725
Rhinitis allergic	10.08	9.96	24	373649	7176	50224275
Osteoporotic fracture	10.08	9.96	48	373625	3097	50228354
Ear infection	10.02	9.96	257	373416	25713	50205738
Incorrect product administration duration	9.99	9.96	35	373638	9240	50222211
Pulmonary alveolar haemorrhage	9.98	9.96	9	373664	4018	50227433
Blood phosphorus decreased	9.96	9.96	8	373665	3781	50227670

FDA Adverse Event Reporting System (Male)

MedDRA adverse event term	Likelihood ratio	Likelihood ratio threshold	Patients taking drug having adverse event	Patients taking drug not having adverse event	Patients not taking drug having adverse event	Patients not taking drug not having adverse event
Rheumatoid arthritis	530.90	9.79	691	133456	31461	29408919
Foetal exposure during pregnancy	305.70	9.79	550	133597	33317	29407063
Drug abuse	296.87	9.79	16	134131	79867	29360513
Toxicity to various agents	223.24	9.79	276	133871	173385	29266995
Arthralgia	215.83	9.79	1222	132925	138395	29301985
Completed suicide	199.15	9.79	80	134067	90166	29350214
Psoriatic arthropathy	156.68	9.79	257	133890	14434	29425946
Dysmorphism	132.37	9.79	109	134038	2862	29437518
Drug interaction	116.74	9.79	480	133667	196905	29243475
Joint swelling	109.56	9.79	481	133666	49149	29391231
Sickle cell anaemia with crisis	108.56	9.79	92	134055	2516	29437864
Premature baby	103.71	9.79	237	133910	17043	29423337
Psoriasis	89.96	9.79	336	133811	31891	29408489
Enthesopathy	89.05	9.79	97	134050	3646	29436734
Exposure during pregnancy	86.32	9.79	146	134001	8408	29431972
Intentional overdose	81.96	9.79	36	134111	38492	29401888
Speech disorder developmental	78.82	9.79	67	134080	1840	29438540
Neonatal respiratory distress syndrome	74.17	9.79	89	134058	3721	29436659
Tenosynovitis	73.98	9.79	88	134059	3645	29436735
Blood pressure fluctuation	72.72	9.79	227	133920	19667	29420713
Musculoskeletal stiffness	70.81	9.79	347	133800	37111	29403269
Acute kidney injury	70.51	9.79	817	133330	264450	29175930
Atrial septal defect	67.35	9.79	115	134032	6674	29433706
Hypospadias	66.60	9.79	75	134072	2927	29437453
Foetal anticonvulsant syndrome	65.46	9.79	49	134098	1115	29439265
Nasopharyngitis	62.44	9.79	474	133673	59191	29381189
Pain	59.88	9.79	1101	133046	170331	29270049
Death	59.60	9.79	1144	133003	340940	29099440
Maternal drugs affecting foetus	58.54	9.79	80	134067	3813	29436567
Overdose	58.51	9.79	177	133970	79642	29360738
Synovitis	58.43	9.79	143	134004	10747	29429633
Drug reaction with eosinophilia and systemic symptoms	58.21	9.79	27	134120	27965	29412415
Maternal exposure during pregnancy	57.92	9.79	82	134065	4041	29436339
Autism spectrum disorder	57.91	9.79	58	134089	1974	29438406
Low birth weight baby	55.38	9.79	104	134043	6504	29433876
Small for dates baby	52.99	9.79	73	134074	3506	29436874
Product use in unapproved indication	52.65	9.79	209	133938	86666	29353714
C-reactive protein abnormal	52.47	9.79	101	134046	6435	29433945
Cryptorchism	50.93	9.79	53	134094	1889	29438491
Learning disorder	50.84	9.79	40	134107	982	29439398
Hypoglycaemia neonatal	50.59	9.79	50	134097	1674	29438706
Suicide attempt	50.58	9.79	48	134099	34062	29406318
Arthritis	48.15	9.79	233	133914	24786	29415594
Coma	47.16	9.79	66	134081	39384	29400996
Serotonin syndrome	46.70	9.79	11	134136	17501	29422879
Hepatic function abnormal	46.61	9.79	66	134081	39193	29401187
Tongue disorder	46.60	9.79	79	134068	4557	29435823
Ventricular septal defect	46.38	9.79	68	134079	3461	29436919
Maternal exposure during breast feeding	45.29	9.79	44	134103	1442	29438938
Drug resistance	44.44	9.79	21	134126	21519	29418861
Rhabdomyolysis	43.73	9.79	136	134011	60672	29379708
Foot deformity	42.47	9.79	70	134077	3945	29436435
Palmar-plantar erythrodysaesthesia syndrome	41.96	9.79	8	134139	14751	29425629
Arthropathy	40.24	9.79	199	133948	21355	29419025
Syndactyly	40.00	9.79	31	134116	744	29439636
Pulmonary fibrosis	39.81	9.79	158	133989	15424	29424956
Febrile neutropenia	39.27	9.79	323	133824	111917	29328463
Basal cell carcinoma	38.89	9.79	166	133981	16744	29423636
Rheumatoid nodule	38.76	9.79	48	134099	2074	29438306
Drug intolerance	38.72	9.79	362	133785	48017	29392363
Developmental delay	38.25	9.79	52	134095	2466	29437914
Haemoglobin decreased	37.75	9.79	696	133451	107679	29332701
Lower respiratory tract infection	37.56	9.79	227	133920	26275	29414105
Osteoarthritis	37.32	9.79	172	133975	17931	29422449
Blood pressure systolic increased	36.94	9.79	163	133984	16682	29423698
Exposure via breast milk	36.67	9.79	42	134105	1670	29438710
Pancytopenia	35.86	9.79	553	133594	82615	29357765
Intentional product misuse	35.73	9.79	64	134083	34597	29405783
Drug dependence	35.45	9.79	26	134121	20955	29419425
Infusion related reaction	34.93	9.79	328	133819	43558	29396822
Joint laxity	34.92	9.79	22	134125	374	29440006
Tendonitis	33.99	9.79	96	134051	7865	29432515
Congenital hand malformation	33.88	9.79	25	134122	556	29439824
Talipes	33.48	9.79	41	134106	1751	29438629
Alanine aminotransferase abnormal	33.25	9.79	53	134094	2904	29437476
Blood pressure increased	32.69	9.79	493	133654	73310	29367070
Bradycardia	32.51	9.79	170	133977	65459	29374921
Jaundice neonatal	32.44	9.79	34	134113	1222	29439158
Angioedema	31.95	9.79	60	134087	31855	29408525
Blood pressure systolic abnormal	31.88	9.79	44	134103	2117	29438263
Hypermobility syndrome	31.84	9.79	20	134127	338	29440042
Intellectual disability	31.57	9.79	32	134115	1105	29439275
Foetal growth restriction	31.22	9.79	59	134088	3707	29436673
Respiratory arrest	31.09	9.79	43	134104	25790	29414590
Pain in extremity	30.75	9.79	686	133461	109747	29330633
Renal failure	30.72	9.79	367	133780	118232	29322148
Language disorder	30.58	9.79	41	134106	1918	29438462
Delirium	29.84	9.79	86	134061	39311	29401069
Joint effusion	29.21	9.79	61	134086	4123	29436257
Cytomegalovirus infection	28.59	9.79	38	134109	23177	29417203
Large for dates baby	28.43	9.79	27	134120	860	29439520
Off label use	28.37	9.79	1097	133050	299703	29140677
Drug withdrawal syndrome	28.22	9.79	24	134123	17960	29422420
Polyarthritis	28.11	9.79	58	134089	3887	29436493
Hyperglycaemia	28.10	9.79	72	134075	34215	29406165
Plagiocephaly	27.93	9.79	21	134126	481	29439899
Serum ferritin increased	27.49	9.79	71	134076	5517	29434863
Peripheral swelling	27.15	9.79	423	133724	63316	29377064
Suicidal ideation	26.86	9.79	75	134072	34641	29405739
Somnolence	26.58	9.79	285	133862	93670	29346710
Hyperbilirubinaemia neonatal	26.51	9.79	24	134123	718	29439662
Cardiac failure	26.44	9.79	231	133916	79056	29361324
Hypoglycaemia	26.38	9.79	121	134026	48225	29392155
Loss of personal independence in daily activities	25.97	9.79	201	133946	25239	29415141
Skin cancer	25.91	9.79	91	134056	8377	29432003
Musculoskeletal pain	25.90	9.79	222	133925	28731	29411649
Knee deformity	25.87	9.79	21	134126	540	29439840
Knee arthroplasty	25.74	9.79	71	134076	5738	29434642
Constipation	25.61	9.79	364	133783	113796	29326584
Sedation	25.21	9.79	25	134122	17380	29423000
Caesarean section	25.19	9.79	37	134110	1886	29438494
Lactic acidosis	25.19	9.79	63	134084	30184	29410196
Hand deformity	25.09	9.79	39	134108	2091	29438289
Dysgraphia	24.96	9.79	38	134109	2000	29438380
Motor developmental delay	24.88	9.79	22	134125	638	29439742
Selective eating disorder	24.74	9.79	34	134113	1629	29438751
Astigmatism	24.46	9.79	26	134121	950	29439430
Behaviour disorder	24.41	9.79	52	134095	3564	29436816
Drug withdrawal syndrome neonatal	24.29	9.79	50	134097	3345	29437035
Agitation	24.24	9.79	135	134012	51169	29389211
Depressed level of consciousness	24.23	9.79	86	134061	36856	29403524
Multiple organ dysfunction syndrome	24.22	9.79	177	133970	62939	29377441
Disease progression	24.18	9.79	246	133901	81670	29358710
Psychotic disorder	23.39	9.79	35	134112	20319	29420061
Otitis media	23.27	9.79	42	134105	2547	29437833
Altered state of consciousness	23.05	9.79	34	134113	19855	29420525
Blood pressure diastolic decreased	22.83	9.79	77	134070	6945	29433435
Strabismus	22.67	9.79	30	134117	1386	29438994
Hypotonia neonatal	22.59	9.79	28	134119	1211	29439169
Body temperature decreased	22.48	9.79	102	134045	10562	29429818
Blood pressure diastolic abnormal	22.44	9.79	41	134106	2510	29437870
Cardiac arrest	22.09	9.79	265	133882	85326	29355054
Hydrocele	21.95	9.79	35	134112	1918	29438462
Pathogen resistance	21.84	9.79	5	134142	8111	29432269
Poisoning	21.78	9.79	9	134138	9984	29430396
C-reactive protein increased	21.70	9.79	301	133846	43962	29396418
Urticaria	21.60	9.79	152	133995	54508	29385872
Medical device implantation	21.34	9.79	19	134128	556	29439824
Crohn's disease	21.16	9.79	44	134103	2965	29437415
Agitation neonatal	21.10	9.79	25	134122	1031	29439349
Dyslexia	20.99	9.79	15	134132	317	29440063
Substance abuse	20.80	9.79	3	134144	6784	29433596
Heart rate decreased	20.72	9.79	188	133959	24724	29415656
Arthritis bacterial	20.61	9.79	55	134092	4358	29436022
Dyspraxia	20.61	9.79	16	134131	385	29439995
Anal fistula	20.32	9.79	53	134094	4142	29436238
Blood creatine phosphokinase increased	20.28	9.79	105	134042	40539	29399841
Wound	20.16	9.79	108	134039	11955	29428425
Juvenile idiopathic arthritis	19.99	9.79	28	134119	1366	29439014
Attention deficit hyperactivity disorder	19.97	9.79	36	134111	2181	29438199
Patent ductus arteriosus	19.96	9.79	44	134103	3087	29437293
Shock	19.91	9.79	42	134105	21362	29419018
Foetal disorder	19.87	9.79	21	134126	762	29439618
Congenital anomaly	19.53	9.79	27	134120	1301	29439079
Post procedural infection	19.45	9.79	53	134094	4252	29436128
Tuberculosis	19.22	9.79	74	134073	7122	29433258
Vitamin D deficiency	19.20	9.79	62	134085	5467	29434913
Psychomotor retardation	19.18	9.79	42	134105	2934	29437446
Colitis ulcerative	19.13	9.79	111	134036	12658	29427722
Lacrimal disorder	19.07	9.79	14	134133	309	29440071
Bronchiolitis	19.04	9.79	40	134107	2715	29437665
Renal aplasia	18.96	9.79	19	134128	647	29439733
Cleft lip	18.95	9.79	14	134133	312	29440068
Congenital bladder anomaly	18.81	9.79	13	134134	260	29440120
Limb reduction defect	18.76	9.79	13	134134	261	29440119
Renal impairment	18.70	9.79	258	133889	81075	29359305
Acute hepatic failure	18.69	9.79	16	134131	11936	29428444
Weight decrease neonatal	18.68	9.79	14	134133	319	29440061
Malignant melanoma	18.60	9.79	73	134074	7088	29433292
Congenital foot malformation	18.47	9.79	15	134132	386	29439994
Haematocrit decreased	18.36	9.79	207	133940	28815	29411565
Neuroleptic malignant syndrome	18.33	9.79	28	134119	16120	29424260
Blood pressure diastolic increased	18.30	9.79	47	134100	3639	29436741
Toxic epidermal necrolysis	18.28	9.79	34	134113	18119	29422261
Back disorder	18.11	9.79	64	134083	5909	29434471
Intentional self-injury	17.93	9.79	18	134129	12443	29427937
Ankyloglossia congenital	17.82	9.79	13	134134	284	29440096
Scoliosis	17.80	9.79	35	134112	2265	29438115
Nasal disorder	17.72	9.79	27	134120	1422	29438958
Hepatic failure	17.71	9.79	78	134069	31434	29408946
Injection site pain	17.71	9.79	225	133922	32221	29408159
Rash maculo-papular	17.68	9.79	54	134093	24235	29416145
Joint range of motion decreased	17.62	9.79	64	134083	5990	29434390
Diaphragmatic disorder	17.59	9.79	22	134125	960	29439420
Haemangioma congenital	17.56	9.79	16	134131	483	29439897
Joint stiffness	17.35	9.79	87	134060	9386	29430994
Lung neoplasm malignant	17.27	9.79	118	134029	14239	29426141
Inflammation	17.15	9.79	168	133979	22560	29417820
Electrocardiogram QT prolonged	17.11	9.79	95	134052	36042	29404338
Microcephaly	17.09	9.79	19	134128	731	29439649
Umbilical hernia	16.89	9.79	46	134101	3689	29436691
Multiple congenital abnormalities	16.89	9.79	16	134131	508	29439872
Hallucination	16.86	9.79	126	134021	44586	29395794
Bradycardia neonatal	16.75	9.79	21	134126	919	29439461
Arthrodesis	16.73	9.79	15	134132	443	29439937
Respiratory disorder neonatal	16.66	9.79	26	134121	1399	29438981
Weight decreased	16.55	9.79	840	133307	150065	29290315
Vitamin B12 deficiency	16.54	9.79	42	134105	3229	29437151
Grip strength decreased	16.53	9.79	34	134113	2273	29438107
Polydactyly	16.50	9.79	23	134124	1117	29439263
Infective pulmonary exacerbation of cystic fibrosis	16.46	9.79	4	134143	6232	29434148
Proteinuria	16.45	9.79	29	134118	15775	29424605
C-reactive protein decreased	16.35	9.79	27	134120	1524	29438856
Diabetic ketoacidosis	16.27	9.79	30	134117	16043	29424337
Pectus excavatum	16.26	9.79	11	134136	212	29440168
Status epilepticus	16.22	9.79	15	134132	10779	29429601
Spinal disorder	16.21	9.79	45	134102	3650	29436730
Red blood cell sedimentation rate increased	16.20	9.79	72	134075	7389	29432991
Septic arthritis staphylococcal	16.05	9.79	15	134132	468	29439912
Hypertelorism	16.01	9.79	16	134131	543	29439837
Respiratory rate increased	15.97	9.79	80	134067	8628	29431752
Ear disorder	15.95	9.79	24	134123	1250	29439130
Neck mass	15.91	9.79	26	134121	1455	29438925
Haemangioma	15.89	9.79	28	134119	1666	29438714
Cellulitis	15.80	9.79	294	133853	45546	29394834
Pyrexia	15.77	9.79	1108	133039	286514	29153866
Immunodeficiency	15.61	9.79	50	134097	4390	29435990
Ankylosing spondylitis	15.58	9.79	48	134099	4128	29436252
Oesophageal fibrosis	15.57	9.79	10	134137	176	29440204
Therapeutic product effect decreased	15.55	9.79	203	133944	29248	29411132
Infection	15.53	9.79	457	133690	76294	29364086
Poor venous access	15.38	9.79	40	134107	3121	29437259
Contraindicated product administered	15.27	9.79	138	134009	18128	29422252
Maternal exposure timing unspecified	15.17	9.79	13	134134	361	29440019
Neurotoxicity	15.04	9.79	27	134120	14586	29425794
Inguinal hernia	14.87	9.79	65	134082	6623	29433757
No adverse event	14.87	9.79	36	134111	17442	29422938
Arnold-Chiari malformation	14.80	9.79	12	134135	308	29440072
Prostate cancer	14.78	9.79	179	133968	25348	29415032
Emphysema	14.74	9.79	78	134069	8593	29431787
Oropharyngeal pain	14.69	9.79	200	133947	29085	29411295
Pneumonia	14.63	9.79	1662	132485	318510	29121870
Hernia pain	14.52	9.79	11	134136	255	29440125
Foetal distress syndrome	14.23	9.79	20	134127	979	29439401
Injection site bruising	14.15	9.79	70	134077	7510	29432870
Oxygen saturation decreased	14.05	9.79	284	133863	44653	29395727
Blood parathyroid hormone decreased	14.03	9.79	18	134129	806	29439574
Foetal heart rate deceleration abnormality	14.01	9.79	14	134133	475	29439905
Vascular insufficiency	13.98	9.79	12	134135	334	29440046
Venoocclusive liver disease	13.88	9.79	7	134140	6910	29433470
Ear infection	13.87	9.79	73	134074	8027	29432353
Pleural fibrosis	13.75	9.79	23	134124	1312	29439068
Diverticular perforation	13.75	9.79	37	134110	2947	29437433
Anal atresia	13.74	9.79	11	134136	277	29440103
Spina bifida	13.74	9.79	12	134135	342	29440038
Peripheral artery thrombosis	13.73	9.79	30	134117	2092	29438288
Unresponsive to stimuli	13.63	9.79	63	134084	25063	29415317
Mouth ulceration	13.60	9.79	87	134060	10268	29430112
Finger deformity	13.60	9.79	21	134126	1119	29439261
Tooth malformation	13.60	9.79	9	134138	167	29440213
Blood insulin increased	13.60	9.79	12	134135	347	29440033
Radiation inflammation	13.57	9.79	10	134137	222	29440158
Developmental coordination disorder	13.19	9.79	9	134138	176	29440204
Drug ineffective for unapproved indication	13.13	9.79	28	134119	14186	29426194
Cerebral haemorrhage	13.10	9.79	86	134061	31340	29409040
Ear malformation	13.07	9.79	11	134136	298	29440082
Congenital hydronephrosis	13.00	9.79	16	134131	687	29439693
Arthritis infective	12.99	9.79	35	134112	2789	29437591
Incorrect route of product administration	12.97	9.79	18	134129	10783	29429597
Haemolysis	12.82	9.79	64	134083	6892	29433488
Respiratory failure	12.77	9.79	339	133808	96792	29343588
Palindromic rheumatism	12.76	9.79	9	134138	186	29440194
Red blood cell sedimentation rate	12.56	9.79	14	134133	540	29439840
Product quality issue	12.55	9.79	34	134113	15861	29424519
Anaphylactic shock	12.54	9.79	26	134121	13310	29427070
Gangrene neonatal	12.52	9.79	9	134138	192	29440188
Hyperammonaemia	12.51	9.79	5	134142	5658	29434722
Kidney infection	12.38	9.79	48	134099	4635	29435745
Neonatal seizure	12.32	9.79	13	134134	471	29439909
Excessive cerumen production	12.29	9.79	10	134137	258	29440122
Pulmonary artery stenosis congenital	12.27	9.79	13	134134	473	29439907
Neonatal infection	12.16	9.79	12	134135	401	29439979
Lung cancer metastatic	12.11	9.79	31	134116	2396	29437984
Progressive multifocal leukoencephalopathy	12.09	9.79	13	134134	8706	29431674
Meningeal disorder	12.07	9.79	11	134136	332	29440048
Hepatic enzyme increased	12.07	9.79	218	133929	33581	29406799
Lipase increased	12.04	9.79	12	134135	8325	29432055
Cleft palate	11.96	9.79	14	134133	570	29439810
Nephrolithiasis	11.90	9.79	171	133976	25163	29415217
Non-Hodgkin's lymphoma	11.85	9.79	23	134124	1474	29438906
Neck pain	11.82	9.79	149	133998	21298	29419082
Osteonecrosis of jaw	11.81	9.79	37	134110	16473	29423907
Stevens-Johnson syndrome	11.78	9.79	37	134110	16460	29423920
Back pain	11.75	9.79	572	133575	101712	29338668
Irritability	11.75	9.79	56	134091	22096	29418284
Second primary malignancy	11.73	9.79	8	134139	6697	29433683
Vomiting	11.72	9.79	817	133330	211443	29228937
Cardiogenic shock	11.71	9.79	46	134101	19144	29421236
Aggression	11.64	9.79	104	134043	35437	29404943
Low set ears	11.59	9.79	12	134135	425	29439955
Malignant neoplasm progression	11.57	9.79	251	133896	73608	29366772
Steatorrhoea	11.57	9.79	15	134132	679	29439701
Sexual dysfunction	11.49	9.79	6	134141	5808	29434572
Educational problem	11.41	9.79	13	134134	514	29439866
Aspergillus infection	11.39	9.79	19	134128	10562	29429818
Synovial cyst	11.36	9.79	26	134121	1871	29438509
Fine motor skill dysfunction	11.28	9.79	23	134124	1528	29438852
Cholelithiasis	11.28	9.79	132	134015	18540	29421840
Wrong technique in product usage process	11.17	9.79	90	134057	31338	29409042
Foetal hypokinesia	11.16	9.79	11	134136	367	29440013
Decreased appetite	11.16	9.79	542	133605	144800	29295580
Lung neoplasm	11.08	9.79	44	134103	4296	29436084
Pharyngeal disorder	10.98	9.79	14	134133	623	29439757
Dermatitis psoriasiform	10.92	9.79	19	134128	1119	29439261
Tonsil cancer	10.90	9.79	17	134130	914	29439466
Localised infection	10.85	9.79	103	134044	13713	29426667
Abnormal behaviour	10.84	9.79	61	134086	23066	29417314
Oesophageal atresia	10.80	9.79	12	134135	461	29439919
Pancreatic duct stenosis	10.80	9.79	8	134139	179	29440201
Granuloma skin	10.79	9.79	14	134133	634	29439746
Acute chest syndrome	10.73	9.79	10	134137	311	29440069
Sinusitis	10.71	9.79	217	133930	34133	29406247
Joint instability	10.66	9.79	11	134136	388	29439992
Skin lesion	10.65	9.79	130	134017	18442	29421938
Moaning	10.64	9.79	15	134132	736	29439644
Neutropenia neonatal	10.64	9.79	14	134133	643	29439737
Hypoxia	10.63	9.79	151	133996	47228	29393152
Chronic obstructive pulmonary disease	10.63	9.79	252	133895	40703	29399677
Mean cell volume increased	10.61	9.79	30	134117	2459	29437921
Maternal exposure before pregnancy	10.58	9.79	12	134135	472	29439908
Nose deformity	10.54	9.79	8	134139	186	29440194
Hypertriglyceridaemia	10.53	9.79	11	134136	7464	29432916
Hepatocellular injury	10.52	9.79	55	134092	21188	29419192
Dysgeusia	10.52	9.79	60	134087	22614	29417766
Tachycardia	10.52	9.79	249	133898	72161	29368219
Agranulocytosis	10.45	9.79	52	134095	20288	29420092
Pulmonary tuberculosis	10.42	9.79	43	134104	4272	29436108
Transfusion-related circulatory overload	10.36	9.79	8	134139	191	29440189
Mesothelioma	10.35	9.79	11	134136	402	29439978
Retinopathy hypertensive	10.32	9.79	9	134138	256	29440124
Psychomotor skills impaired	10.31	9.79	31	134116	2630	29437750
Disseminated intravascular coagulation	10.31	9.79	51	134096	19929	29420451
Skin graft failure	10.26	9.79	7	134140	137	29440243
Congenital diaphragmatic hernia	10.18	9.79	9	134138	261	29440119
Obsessive-compulsive disorder	10.17	9.79	4	134143	4572	29435808
Necrotising fasciitis streptococcal	10.17	9.79	7	134140	139	29440241
Myoclonus	10.11	9.79	29	134118	13280	29427100
Mucosal ulceration	10.10	9.79	16	134131	872	29439508
Glycosylated haemoglobin increased	10.08	9.79	17	134130	9409	29430971
Hypermetropia	10.06	9.79	11	134136	415	29439965
Gross motor delay	10.06	9.79	9	134138	265	29440115
Placental insufficiency	10.06	9.79	6	134141	92	29440288
Pharyngitis	10.01	9.79	60	134087	6923	29433457
Pyelocaliectasis	9.98	9.79	18	134129	1091	29439289
Blood test abnormal	9.97	9.79	52	134095	5697	29434683
Appendix disorder	9.95	9.79	13	134134	593	29439787
Injection site swelling	9.94	9.79	75	134072	9342	29431038
Heart rate irregular	9.91	9.79	97	134050	13020	29427360
Respiratory depression	9.89	9.79	30	134117	13493	29426887
Folate deficiency	9.89	9.79	18	134129	1099	29439281
Tachycardia foetal	9.87	9.79	9	134138	272	29440108
Withdrawal syndrome	9.86	9.79	22	134125	10970	29429410
Chronic graft versus host disease	9.86	9.79	3	134144	4026	29436354
Hepatic siderosis	9.83	9.79	7	134140	147	29440233
Ulna fracture	9.83	9.79	10	134137	347	29440033
Suspected suicide	9.82	9.79	3	134144	4017	29436363

FDA Adverse Event Reporting System (Geriatric)

MedDRA adverse event term	Likelihood ratio	Likelihood ratio threshold	Patients taking drug having adverse event	Patients taking drug not having adverse event	Patients not taking drug having adverse event	Patients not taking drug not having adverse event
Rheumatoid arthritis	1304.89	9.74	2942	376430	161352	63958008
Completed suicide	872.20	9.74	138	379234	224276	63895084
Pemphigus	837.42	9.74	1375	377997	59326	64060034
Arthropathy	828.96	9.74	2046	377326	118921	64000439
Systemic lupus erythematosus	812.65	9.74	1558	377814	76054	64043306
Joint swelling	806.53	9.74	2941	376431	212441	63906919
Hand deformity	775.95	9.74	1354	378018	61417	64057943
Synovitis	755.40	9.74	1747	377625	97343	64022017
Toxicity to various agents	720.69	9.74	647	378725	362866	63756494
Glossodynia	706.03	9.74	1322	378050	63374	64055986
Arthralgia	690.43	9.74	4705	374667	437555	63681805
Maternal exposure during pregnancy	652.71	9.74	1618	377754	94266	64025094
Infusion related reaction	627.28	9.74	2260	377112	162207	63957153
Drug abuse	606.03	9.74	45	379327	132329	63987031
Anti-cyclic citrullinated peptide antibody positive	583.95	9.74	1047	378325	48515	64070845
Wound	571.38	9.74	1338	378034	75139	64044221
Pericarditis	550.48	9.74	1168	378204	61348	64058012
Pain	507.08	9.74	5224	374148	548287	63571073
Abdominal discomfort	467.98	9.74	2218	377154	180104	63939256
Alopecia	437.13	9.74	2032	377340	163658	63955702
Swelling	410.99	9.74	1949	377423	158269	63961091
Therapeutic product effect decreased	406.72	9.74	1546	377826	113805	64005555
Contraindicated product administered	405.06	9.74	1475	377897	106354	64013006
Nasopharyngitis	402.58	9.74	2241	377131	193832	63925528
Discomfort	390.44	9.74	1204	378168	79674	64039686
Drug interaction	384.60	9.74	988	378384	361095	63758265
Rheumatoid factor positive	349.15	9.74	688	378684	34250	64085110
Drug intolerance	342.52	9.74	2082	377290	185910	63933450
Death	341.79	9.74	1569	377803	481136	63638224
Duodenal ulcer perforation	337.78	9.74	675	378697	33950	64085410
Helicobacter infection	336.75	9.74	716	378656	37646	64081714
Exposure during pregnancy	333.68	9.74	1111	378261	76564	64042796
Musculoskeletal stiffness	312.35	9.74	1494	377878	121712	63997648
Hepatic enzyme increased	306.09	9.74	1543	377829	128400	63990960
Intentional overdose	300.08	9.74	79	379293	89865	64029495
Acute kidney injury	264.47	9.74	1555	377817	447685	63671675
Psoriatic arthropathy	253.83	9.74	691	378681	42590	64076770
C-reactive protein abnormal	246.72	9.74	535	378837	28512	64090848
Sinusitis	231.61	9.74	1561	377811	144367	63974993
Impaired healing	225.91	9.74	826	378546	59647	64059713
Febrile neutropenia	225.42	9.74	479	378893	187178	63932182
Overdose	216.28	9.74	379	378993	159187	63960173
Lower respiratory tract infection	206.42	9.74	1100	378272	93514	64025846
Product use issue	202.64	9.74	1557	377815	150158	63969202
Red blood cell sedimentation rate abnormal	199.08	9.74	350	379022	15956	64103404
Peripheral swelling	198.55	9.74	1991	377381	207162	63912198
Cardiac arrest	195.43	9.74	381	378991	153683	63965677
Hypersensitivity	194.70	9.74	1887	377485	194565	63924795
Treatment failure	190.98	9.74	1259	378113	115557	64003803
Muscle injury	183.79	9.74	450	378922	25987	64093373
Blood pressure fluctuation	183.30	9.74	696	378676	51175	64068185
Depressed level of consciousness	178.31	9.74	131	379241	81305	64038055
Arthritis	175.75	9.74	964	378408	82850	64036510
Sickle cell anaemia with crisis	172.95	9.74	184	379188	5148	64114212
Drug ineffective	172.93	9.74	6296	373076	833951	63285409
Folliculitis	168.22	9.74	472	378900	29605	64089755
Suicide attempt	167.81	9.74	105	379267	70902	64048458
Sleep disorder due to general medical condition, insomnia type	162.67	9.74	428	378944	25842	64093518
Hip arthroplasty	160.90	9.74	375	378997	20976	64098384
Knee arthroplasty	160.23	9.74	433	378939	26566	64092794
Irritable bowel syndrome	159.95	9.74	534	378838	36835	64082525
Bradycardia	158.16	9.74	283	379089	117936	64001424
Weight increased	149.46	9.74	1914	377458	211434	63907926
Psoriasis	147.17	9.74	820	378552	70883	64048477
Drug reaction with eosinophilia and systemic symptoms	144.36	9.74	69	379303	54148	64065212
Respiratory arrest	143.28	9.74	66	379306	52919	64066441
Pregnancy	139.59	9.74	350	379022	20515	64098845
Rhabdomyolysis	138.24	9.74	203	379169	91523	64027837
Blister	136.78	9.74	880	378492	80087	64039273
Osteoarthritis	133.79	9.74	730	378642	62606	64056754
Abortion spontaneous	132.29	9.74	386	378986	24757	64094603
Lactic acidosis	131.59	9.74	101	379271	61309	64058051
Cardiac failure	130.58	9.74	374	378998	131999	63987361
Renal failure	128.48	9.74	590	378782	181098	63938262
Injection site erythema	124.85	9.74	778	378594	70022	64049338
Sedation	122.88	9.74	45	379327	41417	64077943
Infection	122.50	9.74	1642	377730	183238	63936122
Hepatic function abnormal	121.74	9.74	119	379253	64194	64055166
Sopor	117.91	9.74	17	379355	29644	64089716
Malignant neoplasm progression	117.22	9.74	311	379061	112560	64006800
Ill-defined disorder	110.65	9.74	533	378839	43519	64075841
Disease progression	109.99	9.74	444	378928	141236	63978124
Red blood cell sedimentation rate increased	109.42	9.74	418	378954	30817	64088543
Enthesopathy	107.60	9.74	199	379173	9439	64109921
Contusion	106.61	9.74	1082	378290	112883	64006477
Serotonin syndrome	106.11	9.74	49	379323	39233	64080127
Constipation	105.78	9.74	852	378520	228485	63890875
Blood pressure systolic increased	105.12	9.74	571	378801	48882	64070478
Injection site pruritus	101.83	9.74	467	378905	37359	64082001
Injection site pain	99.60	9.74	1048	378324	110360	64009000
Hypoglycaemia	99.28	9.74	240	379132	89652	64029708
Neutropenia	97.74	9.74	919	378453	238705	63880655
Drug resistance	97.62	9.74	42	379330	35060	64084300
Hyponatraemia	97.12	9.74	495	378877	147844	63971516
Fatigue	97.02	9.74	5354	374018	743376	63375984
Agitation	95.97	9.74	238	379134	88129	64031231
Joint effusion	95.41	9.74	231	379141	13242	64106118
Hypotension	94.81	9.74	1623	377749	379351	63740009
Condition aggravated	94.09	9.74	2861	376511	369565	63749795
Respiratory failure	93.96	9.74	559	378813	160624	63958736
Multiple organ dysfunction syndrome	93.91	9.74	295	379077	101118	64018242
Blood pressure diastolic abnormal	92.75	9.74	212	379160	11705	64107655
Juvenile idiopathic arthritis	92.22	9.74	114	379258	3765	64115595
Hepatic failure	92.16	9.74	114	379258	55280	64064080
Cytomegalovirus infection	92.12	9.74	52	379320	37147	64082213
Live birth	91.31	9.74	203	379169	11001	64108359
Drug dependence	90.84	9.74	41	379331	33271	64086089
Blood pressure systolic abnormal	88.88	9.74	187	379185	9755	64109605
Osteoporosis	88.17	9.74	484	378888	41596	64077764
Renal impairment	88.13	9.74	451	378921	134566	63984794
Pain in extremity	87.47	9.74	2368	377004	300717	63818643
Product use in unapproved indication	87.11	9.74	644	378728	175974	63943386
Hyperglycaemia	86.99	9.74	140	379232	60828	64058532
Rheumatic fever	86.82	9.74	178	379194	9116	64110244
Coma	86.78	9.74	247	379125	87368	64031992
Rash	86.36	9.74	3405	375967	455144	63664216
Intentional product misuse	86.34	9.74	185	379187	72110	64047250
Injection site reaction	85.55	9.74	518	378854	46146	64073214
Rheumatoid nodule	85.45	9.74	213	379159	12438	64106922
Somnolence	83.89	9.74	779	378593	202866	63916494
Disability assessment scale score increased	83.29	9.74	88	379284	2442	64116918
Cardio-respiratory arrest	83.04	9.74	298	379074	98095	64021265
Injection site swelling	81.58	9.74	468	378904	40885	64078475
Musculoskeletal pain	80.96	9.74	782	378590	80512	64038848
Tenosynovitis	80.73	9.74	200	379172	11633	64107727
Fibromyalgia	80.32	9.74	419	378953	35312	64084048
Swollen joint count increased	79.94	9.74	154	379218	7535	64111825
Electrocardiogram QT prolonged	79.40	9.74	223	379149	79225	64040135
Blood pressure diastolic decreased	79.39	9.74	300	379072	22001	64097359
Grip strength decreased	78.77	9.74	197	379175	11527	64107833
Caesarean section	77.39	9.74	191	379181	11083	64108277
Intentional self-injury	77.26	9.74	37	379335	29007	64090353
Foot deformity	74.34	9.74	240	379132	16264	64103096
Palmar-plantar erythrodysaesthesia syndrome	73.23	9.74	39	379333	28780	64090580
Heart rate decreased	71.68	9.74	562	378810	54505	64064855
Poisoning	71.47	9.74	20	379352	21859	64097501
Blood pressure increased	71.03	9.74	1417	377955	171135	63948225
Hypoxia	70.45	9.74	273	379099	87876	64031484
Joint laxity	70.05	9.74	77	379295	2237	64117123
Device expulsion	69.64	9.74	19	379353	21117	64098243
Disseminated intravascular coagulation	69.55	9.74	53	379319	32295	64087065
Drug withdrawal syndrome	68.91	9.74	50	379322	31241	64088119
C-reactive protein increased	68.71	9.74	857	378515	94052	64025308
Joint stiffness	68.66	9.74	357	379015	30047	64089313
Tachycardia	67.86	9.74	558	378814	149021	63970339
Delirium	67.84	9.74	196	379176	68998	64050362
Localised infection	67.32	9.74	353	379019	29808	64089552
Altered state of consciousness	66.26	9.74	75	379297	37827	64081533
Inflammation	65.43	9.74	629	378743	64671	64054689
Encephalopathy	64.97	9.74	157	379215	58662	64060698
Gastrointestinal disorder	64.92	9.74	810	378562	88899	64030461
Shock	64.35	9.74	78	379294	38162	64081198
Neoplasm progression	64.34	9.74	88	379284	40876	64078484
Injection site bruising	64.29	9.74	400	378972	35973	64083387
Loss of personal independence in daily activities	63.99	9.74	680	378692	71774	64047586
Bone erosion	62.91	9.74	180	379192	11415	64107945
Respiratory depression	62.15	9.74	30	379342	23413	64095947
Basal cell carcinoma	62.14	9.74	351	379021	30487	64088873
Polyarthritis	60.87	9.74	159	379213	9556	64109804
Immune reconstitution inflammatory syndrome	60.76	9.74	3	379369	12467	64106893
Gestational diabetes	60.63	9.74	114	379258	5476	64113884
Thrombocytopenia	59.33	9.74	942	378430	222859	63896501
Femur fracture	58.85	9.74	373	378999	33762	64085598
Tongue disorder	58.39	9.74	180	379192	11900	64107460
Syncope	58.21	9.74	619	378753	157016	63962344
Neuropathy peripheral	58.17	9.74	428	378944	117097	64002263
Blood creatine phosphokinase increased	58.04	9.74	165	379207	58393	64060967
Metabolic acidosis	57.19	9.74	219	379153	70739	64048621
Cardiac failure congestive	57.03	9.74	492	378880	130088	63989272
Cholestasis	56.82	9.74	111	379261	44761	64074599
Oropharyngeal pain	56.62	9.74	784	378588	88083	64031277
Mydriasis	55.94	9.74	11	379361	15301	64104059
Blood pressure diastolic increased	55.53	9.74	164	379208	10588	64108772
Angioedema	55.01	9.74	183	379189	61638	64057722
Anaemia	54.11	9.74	1756	377616	376924	63742436
Cognitive disorder	54.03	9.74	156	379216	54931	64064429
Stomatitis	53.75	9.74	925	378447	108680	64010680
Cerebral haemorrhage	53.60	9.74	140	379232	50950	64068410
Diabetic ketoacidosis	53.33	9.74	58	379314	29787	64089573
Hyperhidrosis	53.08	9.74	474	378898	124446	63994914
Tendonitis	52.81	9.74	248	379124	20034	64099326
Tremor	52.75	9.74	587	378785	147643	63971717
Hepatocellular injury	52.15	9.74	118	379254	45117	64074243
Acute hepatic failure	52.14	9.74	46	379326	26066	64093294
Premature delivery	51.89	9.74	232	379140	18357	64101003
Body temperature decreased	51.51	9.74	294	379078	25634	64093726
Injection site rash	50.54	9.74	205	379167	15537	64103823
Nodule	50.11	9.74	224	379148	17723	64101637
Pulmonary fibrosis	49.97	9.74	324	379048	29554	64089806
Disturbance in attention	49.96	9.74	104	379268	40970	64078390
Hallucination	49.85	9.74	239	379133	72549	64046811
Vomiting	48.94	9.74	2697	376675	548420	63570940
Hypothermia	48.81	9.74	28	379344	19828	64099532
Neuroleptic malignant syndrome	48.76	9.74	45	379327	24951	64094409
Herpes zoster	47.40	9.74	691	378681	78496	64040864
Synovial cyst	47.13	9.74	125	379247	7582	64111778
Tenderness	46.94	9.74	234	379138	19368	64099992
Joint destruction	46.93	9.74	80	379292	3556	64115804
Pre-eclampsia	46.46	9.74	109	379263	6122	64113238
Fracture	46.42	9.74	226	379146	18529	64100831
Sedation complication	46.01	9.74	4	379368	10350	64109010
Hyperkalaemia	45.97	9.74	377	378995	100752	64018608
Maternal exposure before pregnancy	45.44	9.74	77	379295	3406	64115954
Neck deformity	45.09	9.74	53	379319	1659	64117701
Myalgia	44.62	9.74	660	378712	157957	63961403
Abnormal behaviour	44.48	9.74	81	379291	33541	64085819
Disability	44.37	9.74	165	379207	12007	64107353
Infective pulmonary exacerbation of cystic fibrosis	44.11	9.74	8	379364	11788	64107572
Brain oedema	43.95	9.74	39	379333	22036	64097324
Hypokalaemia	43.66	9.74	482	378890	121421	63997939
Joint range of motion decreased	43.59	9.74	227	379145	19116	64100244
Mental status changes	43.55	9.74	198	379174	60964	64058396
Restlessness	43.30	9.74	107	379265	39678	64079682
Anxiety	43.26	9.74	886	378486	201763	63917597
Red blood cell sedimentation rate	43.12	9.74	78	379294	3636	64115724
Asthenia	42.86	9.74	2069	377303	425975	63693385
Speech disorder	42.68	9.74	144	379228	48297	64071063
Myoclonus	42.51	9.74	51	379321	25067	64094293
Alanine aminotransferase abnormal	42.41	9.74	112	379260	6776	64112584
Ventricular tachycardia	42.32	9.74	86	379286	34179	64085181
Joint injury	42.22	9.74	255	379117	22692	64096668
Myocardial infarction	41.93	9.74	704	378668	165117	63954243
Premature rupture of membranes	41.41	9.74	77	379295	3667	64115693
Seizure	41.40	9.74	711	378661	166181	63953179
Skin ulcer	41.33	9.74	418	378954	43556	64075804
Premature labour	41.06	9.74	118	379254	7502	64111858
Neurotoxicity	40.93	9.74	61	379311	27343	64092017
Limb deformity	40.84	9.74	72	379300	3289	64116071
Disorientation	40.79	9.74	179	379193	55649	64063711
Irritability	40.64	9.74	98	379274	36648	64082712
Laryngitis	40.60	9.74	150	379222	10881	64108479
Orthostatic hypotension	40.46	9.74	140	379232	46598	64072762
Dizziness	40.40	9.74	2093	377279	428070	63691290
Unresponsive to stimuli	40.30	9.74	156	379216	50237	64069123
Poor venous access	40.10	9.74	162	379210	12255	64107105
Dyspnoea	39.86	9.74	3663	375709	715011	63404349
Diarrhoea	39.73	9.74	3686	375686	719018	63400342
Neck mass	39.62	9.74	79	379293	3965	64115395
Bronchitis	39.51	9.74	877	378495	107866	64011494
Respiratory distress	39.33	9.74	166	379206	52165	64067195
Multiple sclerosis relapse	39.24	9.74	118	379254	41017	64078343
Venoocclusive liver disease	39.21	9.74	6	379366	10009	64109351
Tuberculosis	38.89	9.74	166	379206	12872	64106488
Cytokine release syndrome	38.88	9.74	39	379333	20790	64098570
Dehydration	38.82	9.74	974	378398	215789	63903571
Leukopenia	38.81	9.74	394	378978	100848	64018512
Oral herpes	38.76	9.74	243	379129	21909	64097451
Ventricular fibrillation	38.75	9.74	50	379322	23810	64095550
Smear cervix abnormal	38.56	9.74	58	379314	2316	64117044
Anaphylactic shock	38.42	9.74	75	379297	30253	64089107
Posterior reversible encephalopathy syndrome	38.40	9.74	47	379325	22899	64096461
Blood glucose increased	38.29	9.74	380	378992	97693	64021667
Neutrophil count decreased	38.25	9.74	281	379091	76915	64042445
Arthritis infective	38.01	9.74	109	379263	6921	64112439
Decreased appetite	37.88	9.74	1314	378058	279975	63839385
Influenza	37.71	9.74	856	378516	105675	64013685
Substance abuse	37.70	9.74	5	379367	9287	64110073
Pulmonary arterial hypertension	37.37	9.74	57	379315	25310	64094050
Ejection fraction decreased	37.23	9.74	70	379302	28637	64090723
Pulmonary embolism	36.79	9.74	622	378750	145734	63973626
Bone disorder	36.61	9.74	195	379177	16564	64102796
Cardiogenic shock	36.25	9.74	86	379286	32341	64087019
Extrapyramidal disorder	36.05	9.74	37	379335	19515	64099845
Latent tuberculosis	36.04	9.74	61	379311	2696	64116664
Spinal stenosis	36.02	9.74	170	379202	13761	64105599
Melaena	35.98	9.74	177	379195	53371	64065989
Multiple fractures	35.96	9.74	97	379275	5943	64113417
Status epilepticus	35.59	9.74	45	379327	21618	64097742
Immunodeficiency	35.49	9.74	188	379184	15936	64103424
Blood creatinine increased	35.46	9.74	573	378799	135209	63984151
Urticaria	35.45	9.74	631	378741	146686	63972674
Psychotic disorder	35.33	9.74	96	379276	34482	64084878
Fear of injection	35.26	9.74	95	379277	5817	64113543
Aggression	35.15	9.74	146	379226	46086	64073274
Therapeutic response decreased	35.12	9.74	465	378907	51723	64067637
Fluid retention	35.08	9.74	206	379166	59400	64059960
Suicidal ideation	35.03	9.74	238	379134	66304	64053056
Drug level increased	34.89	9.74	95	379277	34101	64085259
Pathogen resistance	34.89	9.74	15	379357	12528	64106832
Psychomotor hyperactivity	34.64	9.74	21	379351	14430	64104930
Skin cancer	34.60	9.74	151	379221	11823	64107537
Accidental overdose	34.41	9.74	93	379279	33464	64085896
Nausea	34.25	9.74	4074	375298	781726	63337634
Mouth ulceration	34.23	9.74	316	379056	32128	64087232
Torsade de pointes	34.17	9.74	31	379341	17332	64102028
Product quality issue	34.13	9.74	78	379294	29721	64089639
Wheelchair user	34.04	9.74	81	379291	4591	64114769
Ascites	34.03	9.74	219	379153	61782	64057578
Pancytopenia	33.97	9.74	1093	378279	142216	63977144
Second primary malignancy	33.92	9.74	15	379357	12322	64107038
Inappropriate antidiuretic hormone secretion	33.89	9.74	49	379323	22240	64097120
Aspergillus infection	33.75	9.74	28	379344	16351	64103009
Rash maculo-papular	33.62	9.74	152	379220	46874	64072486
Cerebral infarction	33.50	9.74	126	379246	40918	64078442
Surgery	33.49	9.74	282	379090	27931	64091429
Tenosynovitis stenosans	33.43	9.74	49	379323	1911	64117449
Ear infection	33.34	9.74	244	379128	23160	64096200
Arrhythmia	33.32	9.74	179	379193	52765	64066595
Proteinuria	33.04	9.74	71	379301	27652	64091708
Blood cholesterol increased	32.82	9.74	444	378928	49622	64069738
Gastrointestinal haemorrhage	32.70	9.74	564	378808	131748	63987612
Asphyxia	32.66	9.74	8	379364	9558	64109802
Skin papilloma	32.44	9.74	85	379287	5118	64114242
Agranulocytosis	32.10	9.74	116	379256	38113	64081247
Bradyphrenia	31.86	9.74	8	379364	9398	64109962
Gastroenteritis viral	31.81	9.74	212	379160	19517	64099843
Atrial fibrillation	31.65	9.74	765	378607	170324	63949036
Drug ineffective for unapproved indication	31.38	9.74	87	379285	31046	64088314
Malignant melanoma	31.21	9.74	155	379217	12809	64106551
Balance disorder	31.19	9.74	329	379043	83597	64035763
Bronchopulmonary aspergillosis	30.99	9.74	40	379332	19045	64100315
No adverse event	30.93	9.74	77	379295	28484	64090876
Intentional product use issue	30.91	9.74	757	378615	94607	64024753
Ischaemic stroke	30.89	9.74	79	379293	28956	64090404
Transplant rejection	30.89	9.74	34	379338	17367	64101993
Withdrawal syndrome	30.71	9.74	57	379315	23435	64095925
Joint noise	30.59	9.74	62	379310	3149	64116211
Haematotoxicity	30.55	9.74	19	379353	12877	64106483
Product administration error	30.35	9.74	74	379298	27569	64091791
Injection site warmth	30.34	9.74	158	379214	13304	64106056
Akathisia	30.10	9.74	15	379357	11495	64107865
Emotional distress	29.83	9.74	110	379262	35928	64083432
Foot fracture	29.82	9.74	196	379176	17961	64101399
Vision blurred	29.66	9.74	364	379008	89952	64029408
Mobility decreased	29.52	9.74	687	378685	85153	64034207
Miosis	29.47	9.74	21	379351	13245	64106115
Coagulopathy	29.43	9.74	93	379279	31827	64087533
Synovial fluid analysis	29.37	9.74	41	379331	1528	64117832
Asthma	29.33	9.74	389	378983	94836	64024524
Rotator cuff repair	29.31	9.74	40	379332	1459	64117901
Tachypnoea	29.28	9.74	71	379301	26500	64092860
Gamma-glutamyltransferase increased	28.89	9.74	167	379205	48343	64071017
Unintentional medical device removal	28.87	9.74	3	379369	6731	64112629
Blood parathyroid hormone decreased	28.67	9.74	102	379270	7264	64112096
Acute respiratory failure	28.63	9.74	174	379198	49760	64069600
Shock haemorrhagic	28.51	9.74	34	379338	16757	64102603
Ulcer	28.47	9.74	232	379140	22758	64096602
Acute graft versus host disease	28.40	9.74	9	379363	9075	64110285
Foetal death	28.32	9.74	88	379284	5842	64113518
Rhinorrhoea	27.91	9.74	502	378870	59467	64059893
Maternal exposure timing unspecified	27.87	9.74	54	379318	2653	64116707
Subdural haematoma	27.83	9.74	79	379293	27975	64091385
BK virus infection	27.77	9.74	5	379367	7407	64111953
Loose body in joint	27.68	9.74	35	379337	1183	64118177
Coronary artery disease	27.59	9.74	225	379147	60208	64059152
Tumour lysis syndrome	27.39	9.74	45	379327	19395	64099965
Eosinophilia	27.26	9.74	123	379249	37953	64081407
Forced expiratory volume decreased	27.14	9.74	4	379368	6863	64112497
Muscle spasms	27.07	9.74	627	378745	140396	63978964
Haemoptysis	27.04	9.74	173	379199	48875	64070485
Acute chest syndrome	26.90	9.74	30	379342	886	64118474
Pulmonary oedema	26.63	9.74	315	379057	78359	64041001
Hypertransaminasaemia	26.62	9.74	5	379367	7186	64112174
Oxygen saturation decreased	26.60	9.74	822	378550	106354	64013006
Osteonecrosis of jaw	26.55	9.74	132	379240	39693	64079667
Anaphylactic reaction	26.40	9.74	267	379105	68397	64050963
Fear	26.32	9.74	49	379323	20122	64099238
Dysarthria	26.29	9.74	223	379149	59183	64060177
Dystonia	26.27	9.74	44	379328	18821	64100539
Respiratory disorder	26.25	9.74	116	379256	35995	64083365
Post procedural infection	26.20	9.74	119	379253	9478	64109882
Loss of consciousness	26.19	9.74	668	378704	147697	63971663
Haemorrhage intracranial	26.17	9.74	64	379308	23820	64095540
Blood alkaline phosphatase increased	25.93	9.74	209	379163	56070	64063290
Thrombotic microangiopathy	25.93	9.74	36	379336	16619	64102741
Chronic kidney disease	25.82	9.74	217	379155	57702	64061658
Graft versus host disease	25.63	9.74	26	379346	13787	64105573
Antinuclear antibody positive	25.58	9.74	88	379284	6162	64113198
Erythema multiforme	25.40	9.74	33	379339	15668	64103692
Postoperative wound infection	25.18	9.74	124	379248	10212	64109148
Blood bilirubin increased	25.04	9.74	217	379155	57336	64062024
Toxic skin eruption	25.02	9.74	47	379325	19237	64100123
Sepsis	24.89	9.74	1104	378268	229237	63890123
Toxic epidermal necrolysis	24.88	9.74	123	379249	37043	64082317
Hyperthermia	24.83	9.74	33	379339	15517	64103843
Fracture delayed union	24.74	9.74	43	379329	1942	64117418
Creatinine renal clearance decreased	24.70	9.74	29	379343	14392	64104968
Leukocytosis	24.64	9.74	126	379246	37614	64081746
Clostridium difficile colitis	24.62	9.74	80	379292	27143	64092217
Mania	24.57	9.74	36	379336	16250	64103110
Granuloma skin	24.40	9.74	85	379287	5989	64113371
Cerebrovascular accident	24.40	9.74	619	378753	136964	63982396
Dysgeusia	24.40	9.74	169	379203	46878	64072482
Panniculitis	24.17	9.74	110	379262	8769	64110591
Haemorrhage	24.13	9.74	325	379047	79026	64040334
Pleural effusion	23.92	9.74	564	378808	125995	63993365
Deep vein thrombosis	23.89	9.74	455	378917	104727	64014633
Acute respiratory distress syndrome	23.75	9.74	133	379239	38802	64080558
Polyhydramnios	23.68	9.74	36	379336	1451	64117909
Glycosylated haemoglobin increased	23.59	9.74	36	379336	15983	64103377
Acidosis	23.42	9.74	43	379329	17752	64101608
Scleritis	23.34	9.74	53	379319	2913	64116447
Acute generalised exanthematous pustulosis	23.31	9.74	29	379343	14029	64105331
Drug hypersensitivity	23.06	9.74	1153	378219	236662	63882698
Face oedema	22.93	9.74	72	379300	24689	64094671
Drug use disorder	22.87	9.74	4	379368	6050	64113310
Joint dislocation	22.77	9.74	130	379242	11335	64108025
White blood cell count decreased	22.70	9.74	731	378641	157106	63962254
Jaundice	22.42	9.74	180	379192	48332	64071028
Hyperbilirubinaemia	22.32	9.74	58	379314	21147	64098213
Stillbirth	22.29	9.74	59	379313	3574	64115786
Adverse event	22.22	9.74	341	379031	39148	64080212
Dyskinesia	22.19	9.74	138	379234	39250	64080110
Hypomagnesaemia	22.08	9.74	129	379243	37247	64082113
Pyrexia	22.07	9.74	2914	376458	555730	63563630
Bursitis	22.03	9.74	208	379164	21277	64098083
Stevens-Johnson syndrome	21.99	9.74	115	379257	34134	64085226
Pharyngitis streptococcal	21.85	9.74	105	379267	8563	64110797
Platelet count decreased	21.73	9.74	787	378585	166924	63952436
Aphasia	21.68	9.74	146	379226	40760	64078600
Vertigo	21.65	9.74	232	379140	58779	64060581
Dactylitis	21.61	9.74	40	379332	1898	64117462
Hyperammonaemia	21.58	9.74	16	379356	9888	64109472
Bronchospasm	21.55	9.74	61	379311	21621	64097739
Haemoglobin decreased	21.30	9.74	1375	377997	193688	63925672
Synovial disorder	21.17	9.74	27	379345	921	64118439
Endodontic procedure	21.12	9.74	44	379328	2279	64117081
Febrile bone marrow aplasia	21.09	9.74	21	379351	11234	64108126
Acute graft versus host disease in skin	21.07	9.74	7	379365	6848	64112512
Cardiac failure acute	21.06	9.74	40	379332	16304	64103056
Wrong technique in product usage process	20.90	9.74	263	379109	64711	64054649
Potentiating drug interaction	20.89	9.74	10	379362	7842	64111518
Pulmonary alveolar haemorrhage	20.88	9.74	16	379356	9722	64109638
Cyanosis	20.81	9.74	64	379308	22091	64097269
Pneumatosis intestinalis	20.78	9.74	3	379369	5226	64114134
Breast feeding	20.77	9.74	23	379349	674	64118686
Pulmonary tuberculosis	20.66	9.74	91	379281	7153	64112207
Weight decreased	20.61	9.74	1950	377422	283789	63835571
Lipase increased	20.60	9.74	33	379339	14369	64104991
Pancreatitis	20.42	9.74	238	379134	59369	64059991
Normal newborn	20.35	9.74	76	379296	5541	64113819
Hyperuricaemia	20.29	9.74	18	379354	10173	64109187
Pemphigoid	20.29	9.74	28	379344	12958	64106402
Respiration abnormal	20.21	9.74	6	379366	6309	64113051
Stress cardiomyopathy	20.11	9.74	15	379357	9242	64110118
Depression	20.10	9.74	877	378495	182414	63936946
Incorrect route of product administration	20.02	9.74	70	379302	23228	64096132
Dyspnoea exertional	19.96	9.74	309	379063	73421	64045939
Hallucination, visual	19.87	9.74	90	379282	27744	64091616
Exostosis	19.72	9.74	125	379247	11313	64108047
Lupus-like syndrome	19.69	9.74	103	379269	8688	64110672
Hepatic encephalopathy	19.68	9.74	61	379311	21005	64098355
Adenovirus infection	19.67	9.74	9	379363	7246	64112114
Sinus tachycardia	19.61	9.74	110	379262	32078	64087282
Acute myeloid leukaemia	19.49	9.74	89	379283	27374	64091986
Haemophagocytic lymphohistiocytosis	19.44	9.74	47	379325	17562	64101798
Exposure to toxic agent	19.44	9.74	6	379366	6153	64113207
Human antichimeric antibody positive	19.40	9.74	32	379340	1384	64117976
Endophthalmitis	19.30	9.74	4	379368	5361	64113999
Dermatitis acneiform	19.24	9.74	13	379359	8430	64110930
Device use error	19.21	9.74	7	379365	6464	64112896
Aspartate aminotransferase increased	19.14	9.74	547	378825	119241	64000119
Rebound effect	19.12	9.74	3	379369	4914	64114446
Cushingoid	19.09	9.74	92	379280	7511	64111849
Foetal distress syndrome	19.09	9.74	18	379354	434	64118926
Polyneuropathy	19.02	9.74	57	379315	19837	64099523
Muscle rigidity	19.01	9.74	47	379325	17426	64101934
Haemorrhage in pregnancy	19.00	9.74	30	379342	1250	64118110
Tooth infection	18.98	9.74	149	379223	14452	64104908
Dry eye	18.87	9.74	257	379115	28762	64090598
Mass	18.83	9.74	154	379218	15122	64104238
Nightmare	18.77	9.74	62	379310	20931	64098429
Induced labour	18.74	9.74	24	379348	822	64118538
Cyst	18.65	9.74	128	379244	11899	64107461
Tardive dyskinesia	18.53	9.74	16	379356	9162	64110198
Metastases to bone	18.51	9.74	60	379312	20375	64098985
Klebsiella infection	18.47	9.74	31	379341	13250	64106110
Pancreatitis acute	18.46	9.74	162	379210	42693	64076667
Ingrown hair	18.45	9.74	20	379352	572	64118788
Delusion	18.41	9.74	50	379322	17964	64101396
Haematocrit decreased	18.35	9.74	436	378936	54219	64065141
Nocardiosis	18.34	9.74	3	379369	4764	64114596
Cytomegalovirus viraemia	18.31	9.74	22	379350	10806	64108554
Chronic graft versus host disease	18.28	9.74	7	379365	6269	64113091
Placental disorder	18.21	9.74	24	379348	846	64118514
Musculoskeletal disorder	18.18	9.74	173	379199	17733	64101627
Pulmonary hypertension	18.17	9.74	164	379208	42975	64076385
Anhedonia	18.14	9.74	33	379339	13673	64105687
Hallucination, auditory	18.09	9.74	46	379326	16893	64102467
Polyuria	18.06	9.74	29	379343	12614	64106746
Spinal disorder	18.05	9.74	100	379272	8622	64110738
Muscle spasticity	18.00	9.74	45	379327	16624	64102736
Colitis ulcerative	17.99	9.74	211	379161	22817	64096543
Injection site urticaria	17.94	9.74	120	379252	11061	64108299
Angina pectoris	17.87	9.74	174	379198	44907	64074453
Bone pain	17.87	9.74	186	379186	47386	64071974
Labelled drug-drug interaction medication error	17.83	9.74	68	379304	21994	64097366
Lacrimal disorder	17.83	9.74	18	379354	473	64118887
Polydipsia	17.79	9.74	6	379366	5815	64113545
Frequent bowel movements	17.68	9.74	175	379197	18130	64101230
Arthritis bacterial	17.67	9.74	92	379280	7747	64111613
Flushing	17.62	9.74	341	379031	78307	64041053
Progressive multifocal leukoencephalopathy	17.60	9.74	52	379320	18180	64101180
Tubulointerstitial nephritis	17.56	9.74	108	379264	30801	64088559
Pleuritic pain	17.55	9.74	94	379278	8002	64111358
Heart rate irregular	17.51	9.74	242	379130	27171	64092189
Cardiomyopathy	17.50	9.74	83	379289	25273	64094087
Dislocation of vertebra	17.44	9.74	49	379323	3075	64116285
Cellulitis	17.42	9.74	695	378677	92962	64026398
Tooth abscess	17.38	9.74	140	379232	13686	64105674
Chest discomfort	17.35	9.74	535	378837	115571	64003789
Cytopenia	17.31	9.74	41	379331	15430	64103930
Bone density abnormal	17.27	9.74	45	379327	2700	64116660
Drug-induced liver injury	17.20	9.74	188	379184	47455	64071905
Body height below normal	17.20	9.74	35	379337	1783	64117577
Cystitis haemorrhagic	17.15	9.74	13	379359	7943	64111417
Pain in jaw	17.14	9.74	155	379217	40600	64078760
Urinary retention	17.03	9.74	196	379176	49005	64070355
Sinus bradycardia	16.96	9.74	73	379299	22820	64096540
Anuria	16.96	9.74	56	379316	18908	64100452
Toothache	16.90	9.74	167	379205	17292	64102068
Oliguria	16.82	9.74	38	379334	14538	64104822
Upper respiratory tract infection	16.69	9.74	553	378819	72232	64047128
Placental insufficiency	16.68	9.74	25	379347	995	64118365
Gestational hypertension	16.66	9.74	33	379339	1648	64117712
Hyperlactacidaemia	16.64	9.74	4	379368	4840	64114520
Injection site haemorrhage	16.61	9.74	217	379155	24061	64095299
Acute coronary syndrome	16.60	9.74	58	379314	19252	64100108
Affective disorder	16.58	9.74	9	379363	6571	64112789
Device difficult to use	16.47	9.74	20	379352	9778	64109582
Immunosuppression	16.45	9.74	114	379258	10632	64108728
Blood pressure decreased	16.32	9.74	384	378988	85815	64033545
International normalised ratio increased	16.32	9.74	348	379024	78819	64040541
Wound infection pseudomonas	16.30	9.74	31	379341	1502	64117858
Type 2 diabetes mellitus	16.26	9.74	286	379086	33734	64085626
Sexual dysfunction	16.09	9.74	9	379363	6462	64112898
Tooth disorder	16.08	9.74	202	379170	22200	64097160
Cystitis	16.07	9.74	346	379026	42329	64077031
Insomnia	16.06	9.74	976	378396	196860	63922500
Tuberculin test positive	16.04	9.74	47	379325	3021	64116339
Lymphatic fistula	16.00	9.74	21	379351	737	64118623
Dysphagia	16.00	9.74	492	378880	106320	64013040
Chest pain	16	9.74	1183	378189	234797	63884563
Femoral hernia incarcerated	15.94	9.74	21	379351	740	64118620
Arthropod bite	15.93	9.74	80	379292	6641	64112719
Metastases to lung	15.88	9.74	42	379330	15222	64104138
Atrioventricular block	15.84	9.74	29	379343	11986	64107374
Maternal exposure during breast feeding	15.84	9.74	36	379336	1980	64117380
Hemiplegia	15.80	9.74	32	379340	12736	64106624
Wound infection	15.79	9.74	145	379227	14719	64104641
Epstein-Barr virus infection	15.71	9.74	31	379341	12457	64106903
Pulseless electrical activity	15.71	9.74	32	379340	12707	64106653
Cardiac failure chronic	15.68	9.74	18	379354	9023	64110337
Blood lactic acid increased	15.68	9.74	23	379349	10378	64108982
Gastric haemorrhage	15.67	9.74	35	379337	13446	64105914
Renal injury	15.64	9.74	43	379329	15386	64103974
Off label use	15.61	9.74	3388	375984	629418	63489942
Metastases to liver	15.59	9.74	80	379292	23861	64095499
Kidney infection	15.55	9.74	167	379205	17671	64101689
Sciatica	15.53	9.74	185	379187	20079	64099281
Coronary arterial stent insertion	15.53	9.74	7	379365	5685	64113675
Atrioventricular block complete	15.51	9.74	39	379333	14379	64104981
Septic shock	15.47	9.74	487	378885	104950	64014410
Cervical incompetence	15.44	9.74	17	379355	495	64118865
Peripheral sensory neuropathy	15.42	9.74	27	379345	11351	64108009
Joint lock	15.41	9.74	44	379328	2787	64116573
Electrocardiogram QRS complex prolonged	15.40	9.74	19	379353	9225	64110135
Obstructive airways disorder	15.36	9.74	77	379295	23108	64096252
Pulmonary haemorrhage	15.27	9.74	34	379338	13075	64106285
Hypoalbuminaemia	15.26	9.74	53	379319	17621	64101739
Hepatitis fulminant	15.20	9.74	9	379363	6265	64113095
Clear cell renal cell carcinoma	15.04	9.74	37	379335	2142	64117218
Injection site discolouration	15.02	9.74	80	379292	6795	64112565
Iodine allergy	15.01	9.74	17	379355	511	64118849
Injection site extravasation	14.97	9.74	90	379282	7996	64111364
Haematoma	14.95	9.74	187	379185	46063	64073297
Rheumatoid lung	14.95	9.74	40	379332	2439	64116921
Hypophosphataemia	14.94	9.74	41	379331	14679	64104681
Malignant mediastinal neoplasm	14.85	9.74	17	379355	517	64118843
Alcohol abuse	14.83	9.74	5	379367	4847	64114513
Visual acuity reduced	14.82	9.74	96	379276	27045	64092315
Sickle cell anaemia	14.81	9.74	18	379354	584	64118776
Acute myocardial infarction	14.80	9.74	305	379067	69413	64049947
Nephropathy toxic	14.80	9.74	53	379319	17461	64101899
Aphthous ulcer	14.79	9.74	128	379244	12778	64106582
Abortion threatened	14.74	9.74	15	379357	398	64118962
Antibody test positive	14.68	9.74	39	379333	2368	64116992
Pharyngitis	14.67	9.74	174	379198	18865	64100495
Hypervolaemia	14.66	9.74	149	379223	38136	64081224
Catatonia	14.53	9.74	14	379358	7606	64111754
Disease recurrence	14.52	9.74	117	379255	31393	64087967
Ankle arthroplasty	14.52	9.74	22	379350	884	64118476
Red blood cell count decreased	14.47	9.74	380	378992	48006	64071354
Anger	14.41	9.74	46	379326	15695	64103665
Knee operation	14.36	9.74	59	379313	4498	64114862
Palpitations	14.29	9.74	487	378885	104001	64015359
Joint warmth	14.28	9.74	28	379344	1388	64117972
Cholestasis of pregnancy	14.18	9.74	22	379350	903	64118457
Adjustment disorder with depressed mood	14.17	9.74	39	379333	2418	64116942
Hyperthyroidism	14.07	9.74	57	379315	18122	64101238
Tendon disorder	14.05	9.74	74	379298	6258	64113102
Small for dates baby	13.97	9.74	15	379357	424	64118936
Myopathy	13.96	9.74	55	379317	17625	64101735
Eye infection	13.93	9.74	98	379274	9183	64110177
Finger deformity	13.93	9.74	64	379308	5122	64114238
Nephrolithiasis	13.92	9.74	346	379026	43337	64076023
Muscle twitching	13.82	9.74	61	379311	18937	64100423
Hepatitis acute	13.81	9.74	37	379335	13352	64106008
Transaminases increased	13.79	9.74	182	379190	44412	64074948
Pneumothorax	13.75	9.74	85	379287	24213	64095147
Breast abscess	13.73	9.74	24	379348	1089	64118271
Ileus	13.71	9.74	79	379293	22887	64096473
Respiratory acidosis	13.71	9.74	23	379349	9832	64109528
Hypercapnia	13.69	9.74	15	379357	7679	64111681
Human anti-human antibody test	13.68	9.74	14	379358	374	64118986
Palindromic rheumatism	13.66	9.74	13	379359	317	64119043
C-reactive protein decreased	13.64	9.74	35	379337	2081	64117279
Paralysis	13.57	9.74	30	379342	11565	64107795
Toxic encephalopathy	13.57	9.74	23	379349	9792	64109568
Temperature regulation disorder	13.48	9.74	4	379368	4207	64115153
Foot operation	13.48	9.74	55	379317	4180	64115180
Myocarditis	13.47	9.74	53	379319	16990	64102370
Cytomegalovirus chorioretinitis	13.46	9.74	6	379366	4906	64114454
Hernia	13.43	9.74	130	379242	13388	64105972
Dyslipidaemia	13.39	9.74	21	379351	9221	64110139
Lymphocyte count decreased	13.37	9.74	164	379208	40535	64078825
Foetal exposure during pregnancy	13.36	9.74	57	379315	4419	64114941
Enterocolitis	13.33	9.74	32	379340	11986	64107374
Bacteraemia	13.31	9.74	98	379274	26813	64092547
Osteoporotic fracture	13.30	9.74	49	379323	3549	64115811
Ileus paralytic	13.29	9.74	18	379354	8397	64110963
Right ventricular failure	13.28	9.74	73	379299	21398	64097962
Pulmonary congestion	13.28	9.74	84	379288	23796	64095564
Pseudomonas infection	13.27	9.74	57	379315	17826	64101534
Presyncope	13.26	9.74	137	379235	34952	64084408
Interstitial lung disease	13.25	9.74	456	378916	97276	64022084
Oesophageal fibrosis	13.22	9.74	10	379362	176	64119184
Delivery	13.21	9.74	16	379356	517	64118843
Metastases to central nervous system	13.20	9.74	40	379332	13872	64105488
End stage renal disease	13.18	9.74	26	379346	10449	64108911
Hemiparesis	13.18	9.74	112	379260	29715	64089645
Drug abuser	13.16	9.74	9	379363	5799	64113561
Blood calcium decreased	13.15	9.74	92	379280	25462	64093898
Blood loss anaemia	13.14	9.74	40	379332	13852	64105508
Lip swelling	13.14	9.74	122	379250	31785	64087575
Stress at work	13.08	9.74	22	379350	967	64118393
Bradypnoea	13.08	9.74	7	379365	5152	64114208
Serum ferritin increased	13.06	9.74	90	379282	8378	64110982
Hepatitis cholestatic	12.98	9.74	33	379339	12122	64107238
Lung transplant	12.97	9.74	4	379368	4104	64115256
Retinitis	12.94	9.74	34	379338	2051	64117309
Myofascial pain syndrome	12.92	9.74	31	379341	1767	64117593
Increased tendency to bruise	12.90	9.74	96	379276	9159	64110201
Abortion missed	12.83	9.74	24	379348	1148	64118212
Drug specific antibody	12.83	9.74	34	379338	2061	64117299
Coordination abnormal	12.83	9.74	45	379327	14919	64104441
Drug screen positive	12.82	9.74	9	379363	5720	64113640
Product prescribing error	12.80	9.74	139	379233	35130	64084230
Anal fistula	12.78	9.74	63	379309	5190	64114170
Pancreatic steatosis	12.78	9.74	22	379350	986	64118374
Blood folate increased	12.75	9.74	15	379357	470	64118890
Feeling abnormal	12.70	9.74	649	378723	132953	63986407
Hypocalcaemia	12.69	9.74	171	379201	41582	64077778
Postpartum haemorrhage	12.68	9.74	27	379345	1420	64117940
Bradykinesia	12.57	9.74	12	379360	6548	64112812
Incoherent	12.53	9.74	14	379358	7104	64112256
Abdominal distension	12.53	9.74	450	378922	95544	64023816
Skin ulcer haemorrhage	12.53	9.74	15	379357	479	64118881
Graft versus host disease in skin	12.50	9.74	8	379364	5339	64114021
Therapy non-responder	12.48	9.74	490	378882	65409	64053951
Threatened labour	12.47	9.74	16	379356	549	64118811
Osteopenia	12.41	9.74	143	379229	15397	64103963
Ankylosing spondylitis	12.40	9.74	87	379285	8147	64111213
Pneumonia bacterial	12.37	9.74	46	379326	14989	64104371
Hypernatraemia	12.33	9.74	34	379338	12155	64107205
Skin laceration	12.30	9.74	207	379165	24210	64095150
Chondropathy	12.29	9.74	36	379336	2313	64117047
Hepatocellular carcinoma	12.26	9.74	19	379353	8384	64110976
Lip blister	12.19	9.74	35	379337	2224	64117136
Plasma cell myeloma	12.16	9.74	194	379178	45881	64073479
Hospitalisation	12.12	9.74	343	379029	74864	64044496
Skin neoplasm excision	12.11	9.74	20	379352	866	64118494
Intracranial pressure increased	12.03	9.74	14	379358	6975	64112385
Hepatotoxicity	12.03	9.74	164	379208	39798	64079562
Transplant dysfunction	12.02	9.74	13	379359	6695	64112665
Oligohydramnios	11.94	9.74	43	379329	3081	64116279
Uterine perforation	11.93	9.74	10	379362	5810	64113550
Spinal osteoarthritis	11.92	9.74	133	379239	14208	64105152
Mean cell volume increased	11.91	9.74	60	379312	4986	64114374
Sinus congestion	11.85	9.74	141	379231	15298	64104062
Cholangitis	11.79	9.74	29	379343	10773	64108587
Eosinophil count increased	11.73	9.74	43	379329	14069	64105291
Hepatitis C	11.69	9.74	30	379342	10985	64108375
Labyrinthitis	11.68	9.74	38	379334	2585	64116775
Cardiotoxicity	11.68	9.74	27	379345	10247	64109113
Virologic failure	11.64	9.74	3	379369	3463	64115897
Colitis microscopic	11.63	9.74	16	379356	7416	64111944
Cataract	11.63	9.74	389	378983	50873	64068487
Heparin-induced thrombocytopenia	11.60	9.74	20	379352	8459	64110901
Purpura	11.59	9.74	57	379315	17189	64102171
Swollen joint count	11.55	9.74	16	379356	592	64118768
Hypotonia	11.55	9.74	31	379341	11181	64108179
Sudden death	11.53	9.74	70	379302	20026	64099334
Peritoneal dialysis complication	11.52	9.74	34	379338	2194	64117166
Lower respiratory tract congestion	11.52	9.74	41	379331	2920	64116440
Skin graft failure	11.51	9.74	10	379362	216	64119144
Skin necrosis	11.51	9.74	132	379240	14197	64105163
Vacuum extractor delivery	11.49	9.74	8	379364	123	64119237
Erectile dysfunction	11.49	9.74	37	379335	12590	64106770
Generalised tonic-clonic seizure	11.49	9.74	165	379207	39692	64079668
Mesothelioma	11.44	9.74	12	379360	330	64119030
Alanine aminotransferase increased	11.44	9.74	685	378687	138346	63981014
Schizophrenia	11.41	9.74	31	379341	11137	64108223
Nail injury	11.40	9.74	14	379358	459	64118901
Amylase increased	11.38	9.74	25	379347	9660	64109700
Taste disorder	11.37	9.74	24	379348	9409	64109951
Sensitivity to weather change	11.34	9.74	73	379299	6641	64112719
Myocardial ischaemia	11.34	9.74	85	379287	23166	64096194
Memory impairment	11.33	9.74	401	378971	85281	64034079
Radiation inflammation	11.28	9.74	10	379362	222	64119138
Unevaluable event	11.28	9.74	219	379153	50270	64069090
Hydrocephalus	11.24	9.74	17	379355	7574	64111786
Myelosuppression	11.21	9.74	88	379284	23742	64095618
Medical device site joint infection	11.17	9.74	10	379362	225	64119135
Drug tolerance decreased	11.16	9.74	75	379297	6923	64112437
Accidental death	11.11	9.74	4	379368	3721	64115639
Intestinal ischaemia	11.11	9.74	33	379339	11516	64107844
Catheter management	11.08	9.74	3	379369	3352	64116008
Haematemesis	11.08	9.74	202	379170	46797	64072563
Neck pain	11.07	9.74	455	378917	61078	64058282
Speech disorder developmental	11.06	9.74	15	379357	544	64118816
Carpal tunnel syndrome	11.05	9.74	142	379230	15686	64103674
Complication of device insertion	11.05	9.74	8	379364	5004	64114356
Pancreatic duct stenosis	11.03	9.74	10	379362	229	64119131
Paranoia	11.01	9.74	54	379318	16298	64103062
Nephrotic syndrome	10.99	9.74	25	379347	9542	64109818
Skin infection	10.97	9.74	136	379236	14901	64104459
Benign ovarian tumour	10.96	9.74	11	379361	287	64119073
Musculoskeletal discomfort	10.93	9.74	145	379227	16132	64103228
Failed induction of labour	10.92	9.74	10	379362	232	64119128
Bundle branch block left	10.91	9.74	27	379345	10007	64109353
Device leakage	10.86	9.74	20	379352	8246	64111114
COVID-19 pneumonia	10.83	9.74	55	379317	16449	64102911
Vascular rupture	10.83	9.74	24	379348	1298	64118062
Prostatic specific antigen increased	10.80	9.74	22	379350	8738	64110622
Hypertriglyceridaemia	10.79	9.74	32	379340	11173	64108187
Hyperhomocysteinaemia	10.79	9.74	13	379359	418	64118942
Vascular insufficiency	10.79	9.74	14	379358	486	64118874
Photophobia	10.78	9.74	152	379220	17141	64102219
Generalised oedema	10.77	9.74	75	379297	20778	64098582
Inflammatory bowel disease	10.74	9.74	54	379318	4484	64114876
Hyperlipidaemia	10.73	9.74	85	379287	22891	64096469
Genital haemorrhage	10.70	9.74	10	379362	5512	64113848
Salivary hypersecretion	10.67	9.74	36	379336	12077	64107283
Oedema	10.67	9.74	437	378935	91498	64027862
Diaphragmatic disorder	10.67	9.74	25	379347	1403	64117957
Acute pulmonary oedema	10.66	9.74	39	379333	12770	64106590
Tooth fracture	10.63	9.74	97	379275	9830	64109530
Cartilage injury	10.62	9.74	24	379348	1315	64118045
Hypoxic-ischaemic encephalopathy	10.60	9.74	16	379356	7136	64112224
Device related infection	10.60	9.74	122	379250	30504	64088856
Ventricular arrhythmia	10.60	9.74	17	379355	7398	64111962
Product administered to patient of inappropriate age	10.60	9.74	7	379365	4594	64114766
Gastroenteritis	10.59	9.74	239	379133	29472	64089888
Hernia pain	10.57	9.74	13	379359	427	64118933
Muscular weakness	10.54	9.74	627	378745	126711	63992649
Mental disorder	10.51	9.74	102	379270	26343	64093017
Lung neoplasm malignant	10.50	9.74	181	379191	21267	64098093
Decreased insulin requirement	10.47	9.74	8	379364	143	64119217
Brain natriuretic peptide increased	10.45	9.74	18	379354	7615	64111745
Intestinal stenosis	10.43	9.74	42	379330	3172	64116188
Impaired work ability	10.40	9.74	136	379236	15083	64104277
Diabetes mellitus inadequate control	10.37	9.74	78	379294	21243	64098117
Mycobacterium tuberculosis complex test positive	10.36	9.74	31	379341	2016	64117344
Hiatus hernia	10.35	9.74	170	379202	19787	64099573
Renal disorder	10.34	9.74	146	379226	35219	64084141
Complication of pregnancy	10.33	9.74	11	379361	308	64119052
Therapeutic product effect incomplete	10.31	9.74	724	378648	102758	64016602
Glomerular filtration rate decreased	10.30	9.74	70	379302	19502	64099858
Type 1 diabetes mellitus	10.29	9.74	11	379361	5694	64113666
Hepatic cytolysis	10.29	9.74	45	379327	14004	64105356
Troponin increased	10.29	9.74	51	379321	15348	64104012
Rash erythematous	10.25	9.74	213	379159	48420	64070940
Personality change	10.25	9.74	22	379350	8571	64110789
Thiopurine methyltransferase decreased	10.22	9.74	11	379361	312	64119048
Blood iron increased	10.17	9.74	24	379348	1353	64118007
Peripheral venous disease	10.15	9.74	68	379304	6270	64113090
Intervertebral disc degeneration	10.15	9.74	120	379252	13000	64106360
Umbilical hernia	10.14	9.74	52	379320	4353	64115007
Aspiration	10.12	9.74	58	379314	16827	64102533
Twin pregnancy	10.10	9.74	18	379354	829	64118531
Respiratory tract infection viral	10.09	9.74	36	379336	2567	64116793
Dementia	10.09	9.74	76	379296	20690	64098670
Lymphadenectomy	10.08	9.74	20	379352	1000	64118360
Haemodialysis	10.06	9.74	59	379313	17018	64102342
Varicose ulceration	10.05	9.74	12	379360	382	64118978
Kidney transplant rejection	10.02	9.74	26	379346	9485	64109875
Crying	10.01	9.74	73	379299	20017	64099343
Vascular device infection	9.98	9.74	13	379359	6167	64113193
Skin texture abnormal	9.98	9.74	12	379360	385	64118975
Haematoma infection	9.94	9.74	23	379349	1280	64118080
Blister infected	9.90	9.74	15	379357	603	64118757
Hepatic siderosis	9.89	9.74	8	379364	156	64119204
Aplasia	9.88	9.74	16	379356	6937	64112423
Clavicle fracture	9.88	9.74	46	379326	3703	64115657
Faecal calprotectin increased	9.84	9.74	45	379327	3595	64115765
Laryngospasm	9.77	9.74	4	379368	3441	64115919
Lethargy	9.77	9.74	339	379033	72255	64047105
Excessive cerumen production	9.77	9.74	14	379358	535	64118825
Lymph gland infection	9.76	9.74	12	379360	394	64118966

FDA Adverse Event Reporting System (Pediatric)

None

Pharmacologic Action:

Source	Code	Description
CHEBI has role	CHEBI:50733	Dietary Supplement

Drug Use | Suggest Off label Use Form| |View source of the data|

None

🐶 Veterinary Drug Use

None

🐶 Veterinary products

None

Acid dissociation constants calculated using MoKa v3.0.0

None

Orange Book patent data (new drug applications)

None

Orange Book exclusivity data (new drug applications)

Formulation strength	Trade name	Applicant	Application number	Approval date	Type	Dose form	Route	Exclusivity date	Description
EQ 0.3MG COPPER/ML;EQ 55MCG BASE/ML;EQ 60MCG SELENIUM/ML;EQ 3MG BASE/ML (1ML)	TRALEMENT	AM REGENT	N209376	July 2, 2020	RX	SOLUTION	INTRAVENOUS	April 30, 2024	NEW CHEMICAL ENTITY
EQ 0.3MG COPPER/ML;EQ 55MCG BASE/ML;EQ 60MCG SELENIUM/ML;EQ 3MG BASE/ML (5ML)	TRALEMENT	AM REGENT	N209376	Dec. 2, 2020	RX	SOLUTION	INTRAVENOUS	April 30, 2024	NEW CHEMICAL ENTITY
EQ 60MCG COPPER/ML;EQ 3MCG BASE/ML;EQ 6MCG SELENIUM/ML;EQ 1000MCG BASE/ML (1ML)	MULTRYS	AM REGENT	N209376	June 30, 2021	RX	SOLUTION	INTRAVENOUS	April 30, 2024	NEW CHEMICAL ENTITY

Bioactivity Summary:

None

External reference:

ID	Source
D04854	KEGG_DRUG
4017709	VUID
N0000179176	NUI
4017681	VANDF
4017709	VANDF
CHEBI:86364	CHEBI
CHEMBL1200557	ChEMBL_ID
CHEMBL2103742	ChEMBL_ID
C039798	MESH_SUPPLEMENTAL_RECORD_UI
W00LYS4T26	UNII
24580	PUBCHEM_CID
29268	RXNORM
1544	MMSL
33690	MMSL
5021	MMSL
d00434	MMSL
000858	NDDF
C0065649	UMLSCUI
10034-96-5	SECONDARY_CAS_RN

Pharmaceutical products:

Product	Category	Ingredients	NDC	Form	Quantity	Route	Marketing	Label
Multitrace-4 Neonatal	HUMAN PRESCRIPTION DRUG LABEL	4	0517-6202	INJECTION, SOLUTION	77 mg	INTRAVENOUS	UNAPPROVED DRUG OTHER	14 sections
Manganese Sulfate	HUMAN PRESCRIPTION DRUG LABEL	1	0517-6410	INJECTION, SOLUTION	0.10 mg	INTRAVENOUS	UNAPPROVED DRUG OTHER	13 sections
Multitrace-5	HUMAN PRESCRIPTION DRUG LABEL	5	0517-8201	INJECTION, SOLUTION, CONCENTRATE	1.54 mg	INTRAVENOUS	UNAPPROVED DRUG OTHER	14 sections
Multitrace-5	HUMAN PRESCRIPTION DRUG LABEL	5	0517-8210	INJECTION, SOLUTION, CONCENTRATE	1.54 mg	INTRAVENOUS	UNAPPROVED DRUG OTHER	14 sections
Multitrace-5	HUMAN PRESCRIPTION DRUG LABEL	5	0517-8510	INJECTION, SOLUTION	0.31 mg	INTRAVENOUS	UNAPPROVED DRUG OTHER	14 sections
Multitrace -4 Pediatric	HUMAN PRESCRIPTION DRUG LABEL	4	0517-9203	INJECTION, SOLUTION, CONCENTRATE	77 ug	INTRAVENOUS	UNAPPROVED DRUG OTHER	14 sections
Multrys	HUMAN PRESCRIPTION DRUG LABEL	4	0517-9302	INJECTION, SOLUTION	8.22 ug	INTRAVENOUS	NDA	19 sections
Tralement	HUMAN PRESCRIPTION DRUG LABEL	4	0517-9305	INJECTION, SOLUTION	55 ug	INTRAVENOUS	NDA	22 sections
Trace Elements 4	HUMAN PRESCRIPTION DRUG LABEL	4	0517-9310	INJECTION, SOLUTION	92.30 ug	INTRAVENOUS	UNAPPROVED DRUG OTHER	14 sections
Se-Tan PLUS	HUMAN PRESCRIPTION DRUG LABEL	13	13925-118	CAPSULE, GELATIN COATED	1.30 mg	ORAL	unapproved drug other	19 sections
Se-Tan PLUS	HUMAN PRESCRIPTION DRUG LABEL	13	13925-118	CAPSULE, GELATIN COATED	1.30 mg	ORAL	unapproved drug other	19 sections
Centratex	HUMAN PRESCRIPTION DRUG LABEL	13	23359-100	CAPSULE	1.30 mg	ORAL	unapproved drug other	13 sections
Concept OB	HUMAN PRESCRIPTION DRUG LABEL	15	52747-620	CAPSULE	1.30 mg	ORAL	unapproved drug other	13 sections
PureVit DualFe Plus	HUMAN PRESCRIPTION DRUG LABEL	13	59088-112	CAPSULE	1.30 mg	ORAL	unapproved drug other	12 sections
Vitrexyl	HUMAN PRESCRIPTION DRUG LABEL	17	59088-164	TABLET	2.30 mg	ORAL	unapproved drug other	11 sections
Vitrexyl plus Iron	HUMAN PRESCRIPTION DRUG LABEL	18	59088-165	TABLET	2.30 mg	ORAL	unapproved drug other	13 sections
Prenatrix	HUMAN PRESCRIPTION DRUG LABEL	20	59088-166	TABLET	2.60 mg	ORAL	unapproved drug other	13 sections
Vitrexate	HUMAN PRESCRIPTION DRUG LABEL	17	59088-167	TABLET	2.30 mg	ORAL	unapproved drug other	11 sections
Vitrexate FE	HUMAN PRESCRIPTION DRUG LABEL	18	59088-168	TABLET	2.30 mg	ORAL	unapproved drug other	13 sections
Prenatryl	HUMAN PRESCRIPTION DRUG LABEL	20	59088-169	TABLET	2.60 mg	ORAL	unapproved drug other	13 sections
Vitranol	HUMAN PRESCRIPTION DRUG LABEL	17	59088-171	TABLET	2.30 mg	ORAL	unapproved drug other	11 sections
Prometa	HUMAN PRESCRIPTION DRUG LABEL	20	59088-172	TABLET	2.60 mg	ORAL	unapproved drug other	13 sections
Vitranol Fe	HUMAN PRESCRIPTION DRUG LABEL	18	59088-173	TABLET	2.30 mg	ORAL	unapproved drug other	13 sections
Venexa	HUMAN PRESCRIPTION DRUG LABEL	17	59088-176	TABLET	2.30 mg	ORAL	unapproved drug other	11 sections
Venexa FE	HUMAN PRESCRIPTION DRUG LABEL	18	59088-177	TABLET	2.30 mg	ORAL	unapproved drug other	13 sections
Pretrate	HUMAN PRESCRIPTION DRUG LABEL	20	59088-178	TABLET	2.60 mg	ORAL	unapproved drug other	13 sections
Zintrexyl-C	HUMAN PRESCRIPTION DRUG LABEL	24	59088-180	TABLET	0.75 mg	ORAL	unapproved drug other	13 sections
Folitin-Z	HUMAN PRESCRIPTION DRUG LABEL	24	59088-181	TABLET	0.75 mg	ORAL	unapproved drug other	13 sections
Ribotin-E	HUMAN PRESCRIPTION DRUG LABEL	24	59088-182	TABLET	0.75 mg	ORAL	unapproved drug other	13 sections
Ventrixyl	HUMAN PRESCRIPTION DRUG LABEL	17	59088-186	TABLET	2.30 mg	ORAL	unapproved drug other	12 sections