manganese sulfate 🐶 Veterinary Use | Indications/Contra | FAERs-F | FAERs-M | Orange Bk | BioActivity |

Stem definitionDrug idCAS RN
4461 7785-87-7

Description:

MoleculeDescription

Synonyms:

  • manganese sulfate
  • Molecular weight: 150.99
  • Formula: MnO4S
  • CLOGP:
  • LIPINSKI: None
  • HAC: None
  • HDO: None
  • TPSA: 80.26
  • ALOGS:
  • ROTB: None

Drug dosage:

None

ADMET properties:

None

Approvals:

DateAgencyCompanyOrphan
None FDA

FDA Adverse Event Reporting System (Female)

MedDRA adverse event termLikelihood ratioLikelihood ratio thresholdPatients taking drug having adverse eventPatients taking drug not having adverse eventPatients not taking drug having adverse eventPatients not taking drug not having adverse event
Pemphigus 1648.04 9.96 3081 370592 117085 50114366
Systemic lupus erythematosus 1536.61 9.96 3279 370394 137343 50094108
Glossodynia 1322.62 9.96 2747 370926 112822 50118629
Rheumatoid arthritis 1074.38 9.96 3612 370061 198938 50032513
Hand deformity 1054.03 9.96 2302 371371 97897 50133554
Arthropathy 948.31 9.96 2939 370734 154967 50076484
Maternal exposure during pregnancy 947.70 9.96 2961 370712 156817 50074634
Alopecia 927.44 9.96 3922 369751 241125 49990326
Abdominal discomfort 907.42 9.96 3747 369926 227894 50003557
Wound 860.72 9.96 2199 371474 103595 50127856
Completed suicide 742.24 9.96 62 373611 131827 50099624
Infusion related reaction 687.93 9.96 2774 370899 166783 50064668
Synovitis 686.08 9.96 2243 371430 121622 50109829
Pericarditis 656.78 9.96 1652 372021 77037 50154414
Anti-cyclic citrullinated peptide antibody positive 645.57 9.96 1535 372138 69052 50162399
Contraindicated product administered 631.44 9.96 2471 371202 146487 50084964
Discomfort 615.80 9.96 1980 371693 106400 50125051
Swelling 594.52 9.96 2993 370680 197879 50033572
Joint swelling 577.59 9.96 3434 370239 241852 49989599
Pain 570.13 9.96 6648 367025 572255 49659196
Toxicity to various agents 543.87 9.96 462 373211 212037 50019414
Death 448.68 9.96 1096 372577 324283 49907168
Product use issue 402.24 9.96 2170 371503 147305 50084146
Rheumatoid factor positive 395.31 9.96 1027 372646 48832 50182619
Duodenal ulcer perforation 372.44 9.96 950 372723 44661 50186790
Arthralgia 370.13 9.96 4898 368775 433804 49797647
Helicobacter infection 360.93 9.96 991 372682 48711 50182740
Drug interaction 331.27 9.96 605 373068 199016 50032435
Hepatic enzyme increased 330.81 9.96 1936 371737 135444 50096007
Drug abuse 315.86 9.96 36 373637 59810 50171641
Intentional overdose 307.40 9.96 47 373626 62457 50168994
Exposure during pregnancy 285.87 9.96 1697 371976 119318 50112133
Drug intolerance 251.65 9.96 2598 371075 216506 50014945
Hip arthroplasty 249.62 9.96 635 373038 29794 50201657
Musculoskeletal stiffness 248.70 9.96 1713 371960 126768 50104683
Therapeutic product effect decreased 239.60 9.96 1773 371900 134277 50097174
Treatment failure 234.66 9.96 1780 371893 135857 50095594
Knee arthroplasty 230.31 9.96 684 372989 35162 50196289
Febrile neutropenia 216.33 9.96 241 373432 97426 50134025
Overdose 207.06 9.96 259 373414 99468 50131983
Psoriatic arthropathy 195.44 9.96 776 372897 46256 50185195
Suicide attempt 195.05 9.96 69 373604 51663 50179788
Nasopharyngitis 194.31 9.96 2229 371444 190698 50040753
Acute kidney injury 190.88 9.96 950 372723 227108 50004343
Cardiac arrest 185.70 9.96 206 373467 83445 50148006
Depressed level of consciousness 178.34 9.96 80 373593 51873 50179578
Red blood cell sedimentation rate abnormal 169.81 9.96 374 373299 15969 50215482
Hypersensitivity 165.02 9.96 2364 371309 212797 50018654
Malignant neoplasm progression 161.06 9.96 159 373514 67965 50163486
Diarrhoea 156.85 9.96 3237 370436 585239 49646212
C-reactive protein abnormal 154.90 9.96 505 373168 27304 50204147
Disease progression 150.56 9.96 300 373373 95566 50135885
Drug hypersensitivity 148.62 9.96 1164 372509 249846 49981605
Impaired healing 148.52 9.96 953 372720 68833 50162618
Constipation 146.08 9.96 790 372883 184918 50046533
Device expulsion 145.58 9.96 20 373653 28802 50202649
Nausea 142.51 9.96 4046 369627 701352 49530099
Rheumatic fever 142.51 9.96 356 373317 16511 50214940
Drug ineffective 140.54 9.96 7388 366285 811945 49419506
Swollen joint count increased 137.49 9.96 325 373348 14548 50216903
Sickle cell anaemia with crisis 133.02 9.96 166 373507 4377 50227074
Bradycardia 132.99 9.96 168 373505 64258 50167193
Lactic acidosis 130.06 9.96 42 373631 33313 50198138
Neutropenia 127.95 9.96 609 373064 147356 50084095
Sedation 125.79 9.96 35 373638 30575 50200876
Cardiac failure 125.47 9.96 231 373442 75809 50155642
Hyponatraemia 122.01 9.96 337 373336 95802 50135649
Asthenia 121.79 9.96 1642 372031 317400 49914051
Anxiety 118.88 9.96 795 372878 176811 50054640
Tremor 117.79 9.96 443 373230 114460 50116991
Electrocardiogram QT prolonged 115.99 9.96 127 373546 51759 50179692
Hypotension 112.96 9.96 1152 372521 234317 49997134
Somnolence 110.73 9.96 680 372993 154305 50077146
Pregnancy 108.70 9.96 470 373203 29107 50202344
Dizziness 108.12 9.96 1853 371820 344516 49886935
Dyspnoea 106.76 9.96 3155 370518 544453 49686998
Fatigue 106.41 9.96 6306 367367 701295 49530156
Rash 105.93 9.96 4088 369585 433383 49798068
Respiratory arrest 104.89 9.96 45 373628 29964 50201487
Agitation 104.26 9.96 145 373528 53239 50178212
Sleep disorder due to general medical condition, insomnia type 103.77 9.96 484 373189 30963 50200488
Vomiting 102.84 9.96 2604 371069 458154 49773297
Muscle injury 101.78 9.96 542 373131 36569 50194882
Psoriasis 101.45 9.96 863 372810 68137 50163314
Renal failure 101.11 9.96 424 373249 106209 50125242
Folliculitis 100.93 9.96 563 373110 38662 50192789
Arthritis 99.16 9.96 1028 372645 85693 50145758
Live birth 97.78 9.96 305 373368 16103 50215348
Multiple sclerosis relapse 97.32 9.96 104 373569 42860 50188591
Abortion spontaneous 95.44 9.96 581 373092 41191 50190260
Lower respiratory tract infection 95.26 9.96 1099 372574 94102 50137349
Drug reaction with eosinophilia and systemic symptoms 92.59 9.96 47 373626 28377 50203074
Rhabdomyolysis 92.33 9.96 91 373582 38936 50192515
Blister 91.79 9.96 1000 372673 84418 50147033
Sopor 88.96 9.96 19 373654 19860 50211591
Intentional self-injury 88.53 9.96 30 373643 23082 50208369
Osteoarthritis 86.52 9.96 830 372843 67776 50163675
Hyperhidrosis 86.38 9.96 353 373320 89073 50142378
Neuropathy peripheral 84.91 9.96 396 373277 96361 50135090
Neoplasm progression 83.92 9.96 56 373617 29101 50202350
Condition aggravated 83.03 9.96 2822 370851 294236 49937215
Drug withdrawal syndrome 80.91 9.96 42 373631 25039 50206412
Injection site erythema 80.83 9.96 878 372795 74058 50157393
Insomnia 80.74 9.96 863 372810 174002 50057449
Cardio-respiratory arrest 78.42 9.96 176 373497 53716 50177735
Syncope 76.12 9.96 447 373226 102555 50128896
Blood pressure fluctuation 76.05 9.96 489 373184 35334 50196117
Tachycardia 75.84 9.96 429 373244 99334 50132117
Irritable bowel syndrome 74.88 9.96 642 373031 50799 50180652
Myalgia 74.62 9.96 574 373099 123745 50107706
Product quality issue 74.10 9.96 71 373602 30787 50200664
Drug dependence 73.37 9.96 27 373646 19732 50211719
Serotonin syndrome 73.12 9.96 46 373627 24667 50206784
Hypoglycaemia 72.38 9.96 182 373491 53399 50178052
Renal impairment 72.24 9.96 300 373373 75361 50156090
Joint effusion 71.19 9.96 235 373438 12786 50218665
Hepatic failure 71.07 9.96 80 373593 32203 50199248
Anaemia 70.99 9.96 1375 372298 251081 49980370
Encephalopathy 70.50 9.96 87 373586 33624 50197827
Cognitive disorder 70.17 9.96 137 373536 43986 50187465
Injection site pruritus 70.08 9.96 525 373148 39886 50191565
Hypoxia 68.79 9.96 174 373499 50949 50180502
Coma 68.03 9.96 205 373468 56674 50174777
Palmar-plantar erythrodysaesthesia syndrome 67.33 9.96 32 373641 20066 50211385
Hyperglycaemia 64.21 9.96 106 373567 36299 50195152
Caesarean section 64.10 9.96 257 373416 15382 50216069
Juvenile idiopathic arthritis 64.05 9.96 92 373581 2787 50228664
Disability assessment scale score increased 64.04 9.96 83 373590 2275 50229176
Basal cell carcinoma 63.96 9.96 341 373332 23015 50208436
Sinusitis 63.45 9.96 1679 371994 168879 50062572
Respiratory failure 63.04 9.96 404 373269 90777 50140674
Drug resistance 62.45 9.96 31 373642 18958 50212493
Red blood cell sedimentation rate increased 62.11 9.96 401 373272 29015 50202436
Intentional product misuse 61.39 9.96 161 373512 46573 50184878
Metabolic acidosis 61.35 9.96 121 373552 38704 50192747
No adverse event 60.88 9.96 96 373577 33482 50197969
Asthma 60.66 9.96 398 373275 88939 50142512
Thrombocytopenia 59.75 9.96 628 373045 127045 50104406
Feeling abnormal 59.66 9.96 615 373058 124877 50106574
Hepatic function abnormal 58.72 9.96 94 373579 32587 50198864
Cardiac failure congestive 58.27 9.96 374 373299 84008 50147443
Muscle spasms 58.18 9.96 619 373054 124934 50106517
Foot deformity 57.84 9.96 288 373385 18922 50212529
Urticaria 57.54 9.96 645 373028 128916 50102535
Ill-defined disorder 56.93 9.96 636 373037 54018 50177433
Joint laxity 56.86 9.96 79 373594 2319 50229132
Balance disorder 56.69 9.96 298 373375 70292 50161159
Contusion 56.43 9.96 1152 372521 111031 50120420
Multiple organ dysfunction syndrome 56.28 9.96 187 373486 50150 50181301
Diabetic ketoacidosis 56.08 9.96 31 373642 17841 50213610
Blood glucose increased 55.67 9.96 304 373369 71020 50160431
Fluid retention 54.03 9.96 192 373481 50457 50180994
Blood pressure diastolic abnormal 53.93 9.96 172 373501 9189 50222262
Hallucination 53.78 9.96 171 373502 46486 50184965
Muscle spasticity 53.64 9.96 30 373643 17154 50214297
Injection site swelling 53.45 9.96 507 373166 41266 50190185
Injection site reaction 53.38 9.96 585 373088 49447 50182004
Osteoporosis 53.18 9.96 536 373137 44343 50187108
Altered state of consciousness 53.09 9.96 50 373623 21860 50209591
Peripheral swelling 52.89 9.96 1938 371735 203998 50027453
Cholestasis 52.65 9.96 66 373607 25335 50206116
Sedation complication 52.52 9.96 3 373670 8763 50222688
Blood cholesterol increased 52.36 9.96 631 373042 54584 50176867
Pulmonary embolism 52.29 9.96 489 373184 101215 50130236
Fibromyalgia 52.25 9.96 535 373138 44443 50187008
Injection site pain 52.23 9.96 1129 372544 109895 50121556
Seizure 51.88 9.96 588 373085 117286 50114165
Orthostatic hypotension 51.84 9.96 86 373587 29395 50202056
Respiratory disorder 51.19 9.96 95 373578 31092 50200359
Disturbance in attention 51.19 9.96 95 373578 31091 50200360
Mental status changes 50.72 9.96 121 373552 36151 50195300
Foetal exposure during pregnancy 50.62 9.96 361 373312 26998 50204453
Vision blurred 50.59 9.96 356 373317 78291 50153160
Type 2 diabetes mellitus 50.01 9.96 429 373244 33946 50197505
Dehydration 49.90 9.96 808 372865 151641 50079810
Cytomegalovirus infection 49.70 9.96 36 373637 17926 50213525
Grip strength decreased 49.53 9.96 199 373474 11922 50219529
Chest discomfort 49.32 9.96 442 373231 92280 50139171
Hypokalaemia 49.22 9.96 414 373259 87578 50143873
Bone erosion 48.66 9.96 193 373480 11494 50219957
Loss of personal independence in daily activities 48.62 9.96 757 372916 69293 50162158
Emotional distress 48.22 9.96 86 373587 28577 50202874
Hepatocellular injury 48.17 9.96 73 373600 25874 50205577
Premature labour 48.17 9.96 190 373483 11286 50220165
Mydriasis 47.88 9.96 10 373663 10617 50220834
Restlessness 47.54 9.96 70 373603 25103 50206348
Metastases to bone 47.32 9.96 38 373635 17957 50213494
Blood pressure systolic increased 47.24 9.96 434 373239 35015 50196436
Neutrophil count decreased 46.77 9.96 178 373495 45848 50185603
Ejection fraction decreased 46.38 9.96 41 373632 18479 50212972
Pulmonary arterial hypertension 46.22 9.96 49 373624 20270 50211181
Depression 45.83 9.96 903 372770 164520 50066931
Blood pressure systolic abnormal 45.69 9.96 143 373530 7563 50223888
Gestational diabetes 45.62 9.96 140 373533 7325 50224126
Decreased appetite 45.59 9.96 1132 372541 199791 50031660
Anaphylactic reaction 44.64 9.96 226 373447 53829 50177622
Loss of consciousness 44.57 9.96 524 373149 103829 50127622
Poisoning 44.46 9.96 18 373655 12411 50219040
Hyperkalaemia 44.46 9.96 193 373480 47896 50183555
White blood cell count decreased 44.30 9.96 601 373072 116121 50115330
Dyspnoea exertional 44.15 9.96 211 373462 51022 50180429
Product use in unapproved indication 44.08 9.96 596 373077 115223 50116228
Delirium 44.00 9.96 140 373533 38052 50193399
Infection 43.99 9.96 1626 372047 171328 50060123
Neck deformity 43.70 9.96 63 373610 1915 50229536
Product administration error 43.16 9.96 49 373624 19650 50211801
Hospitalisation 42.97 9.96 309 373364 67628 50163823
Osteonecrosis of jaw 42.76 9.96 112 373561 32414 50199037
Speech disorder 42.59 9.96 128 373545 35420 50196031
Shock 42.44 9.96 54 373619 20596 50210855
Tuberculosis 42.37 9.96 167 373506 9916 50221535
Weight increased 42.32 9.96 1859 371814 200032 50031419
Multiple fractures 42.30 9.96 126 373547 6485 50224966
Hypothermia 42.02 9.96 18 373655 11998 50219453
Respiratory depression 41.99 9.96 18 373655 11992 50219459
Maternal drugs affecting foetus 41.67 9.96 106 373567 4971 50226480
Disorientation 41.63 9.96 129 373544 35355 50196096
Suicidal ideation 41.62 9.96 239 373434 55146 50176305
Rheumatoid nodule 41.27 9.96 195 373478 12540 50218911
Extrapyramidal disorder 40.58 9.96 18 373655 11752 50219699
Leukopenia 40.39 9.96 312 373361 67216 50164235
Memory impairment 40.17 9.96 383 373290 78977 50152474
Acute hepatic failure 40.11 9.96 34 373639 15643 50215808
Myocardial infarction 39.99 9.96 442 373231 88585 50142866
Creatinine renal clearance decreased 39.67 9.96 19 373654 11862 50219589
Blood pressure decreased 39.52 9.96 246 373427 55663 50175788
Blood creatine phosphokinase increased 39.27 9.96 85 373588 26282 50205169
Gamma-glutamyltransferase increased 38.18 9.96 103 373570 29520 50201931
Angioedema 38.09 9.96 146 373527 37530 50193921
Drug level increased 37.95 9.96 52 373621 19216 50212235
Abnormal behaviour 37.77 9.96 54 373619 19604 50211847
Unresponsive to stimuli 37.55 9.96 109 373564 30500 50200951
Ascites 37.54 9.96 137 373536 35724 50195727
Posterior reversible encephalopathy syndrome 37.44 9.96 33 373640 14895 50216556
Pre-eclampsia 36.90 9.96 137 373536 7907 50223544
Pain in jaw 36.90 9.96 152 373521 38276 50193175
Joint stiffness 36.88 9.96 364 373309 29944 50201507
Enthesopathy 36.83 9.96 127 373546 7066 50224385
Blood pressure diastolic decreased 36.80 9.96 231 373442 16550 50214901
Deep vein thrombosis 36.58 9.96 355 373318 72949 50158502
Localised infection 36.52 9.96 317 373356 25168 50206283
Polyarthritis 36.36 9.96 135 373538 7792 50223659
Platelet count decreased 36.31 9.96 524 373149 100202 50131249
Blood alkaline phosphatase increased 36.30 9.96 148 373525 37378 50194073
Accidental overdose 36.22 9.96 55 373618 19478 50211973
Intentional product use issue 36.10 9.96 782 372891 76136 50155315
Disseminated intravascular coagulation 36.06 9.96 44 373629 17091 50214360
Metastases to liver 35.95 9.96 58 373615 20046 50211405
Ventricular septal defect 35.94 9.96 87 373586 3954 50227497
Blood bilirubin increased 35.82 9.96 119 373554 31919 50199532
Cerebral haemorrhage 35.67 9.96 93 373580 26959 50204492
Dysgeusia 35.48 9.96 157 373516 38759 50192692
Nodule 35.41 9.96 231 373442 16772 50214679
Bone pain 35.38 9.96 204 373469 47025 50184426
Maternal exposure before pregnancy 35.17 9.96 106 373567 5491 50225960
Vertigo 35.13 9.96 231 373442 51601 50179850
Dysarthria 34.64 9.96 150 373523 37253 50194198
Flushing 34.52 9.96 322 373351 66693 50164758
Infective pulmonary exacerbation of cystic fibrosis 34.50 9.96 8 373665 7901 50223550
Injection site rash 34.44 9.96 221 373452 15956 50215495
Palpitations 34.29 9.96 491 373182 94015 50137436
Blood calcium decreased 34.05 9.96 63 373610 20643 50210808
Brain oedema 33.95 9.96 25 373648 12345 50219106
Aspartate aminotransferase increased 33.94 9.96 390 373283 77608 50153843
Limb deformity 33.87 9.96 81 373592 3653 50227798
Arrhythmia 33.75 9.96 128 373545 33004 50198447
Torsade de pointes 33.69 9.96 23 373650 11812 50219639
C-reactive protein increased 33.53 9.96 683 372990 65791 50165660
Pulmonary fibrosis 33.48 9.96 301 373372 24136 50207315
Injection site bruising 33.47 9.96 417 373256 36351 50195100
Joint destruction 33.44 9.96 83 373590 3833 50227618
Device dislocation 33.31 9.96 68 373605 21478 50209973
Tenderness 33.21 9.96 243 373430 18322 50213129
Dysphagia 33.19 9.96 389 373284 77129 50154322
Chronic kidney disease 33.00 9.96 166 373507 39605 50191846
Inflammation 32.88 9.96 597 373076 56315 50175136
Haemorrhage 32.87 9.96 245 373428 53196 50178255
Premature delivery 32.69 9.96 292 373381 23371 50208080
Musculoskeletal pain 32.35 9.96 729 372944 71448 50160003
Drug ineffective for unapproved indication 32.19 9.96 68 373605 21213 50210238
Disability 31.95 9.96 182 373491 12593 50218858
Premature rupture of membranes 31.91 9.96 90 373583 4490 50226961
Small for dates baby 31.75 9.96 76 373597 3429 50228022
Anaphylactic shock 31.68 9.96 63 373610 20092 50211359
Femur fracture 31.62 9.96 419 373254 37045 50194406
Nightmare 31.09 9.96 44 373629 16042 50215409
Alanine aminotransferase increased 31.03 9.96 462 373211 87897 50143554
Akathisia 30.97 9.96 11 373662 8218 50223233
Chest pain 30.88 9.96 1033 372640 175849 50055602
Ventricular fibrillation 30.76 9.96 20 373653 10539 50220912
Diabetes mellitus inadequate control 30.69 9.96 31 373642 13114 50218337
Wrong technique in product usage process 30.66 9.96 262 373411 55248 50176203
Tenosynovitis stenosans 30.36 9.96 57 373616 2167 50229284
Heart rate decreased 30.31 9.96 407 373266 36090 50195361
Cytokine release syndrome 30.09 9.96 13 373660 8621 50222830
Pleural effusion 29.97 9.96 422 373251 81032 50150419
Neuroleptic malignant syndrome 29.90 9.96 23 373650 11107 50220344
Ventricular tachycardia 29.87 9.96 44 373629 15777 50215674
Respiratory distress 29.64 9.96 120 373553 30369 50201082
Joint range of motion decreased 29.58 9.96 236 373437 18276 50213175
Inappropriate antidiuretic hormone secretion 29.55 9.96 32 373641 13111 50218340
Withdrawal syndrome 29.39 9.96 53 373620 17537 50213914
Pulmonary oedema 28.85 9.96 227 373446 48711 50182740
Neurotoxicity 28.81 9.96 40 373633 14700 50216751
Smear cervix abnormal 28.78 9.96 63 373610 2678 50228773
Psychotic disorder 28.75 9.96 75 373598 21737 50209714
Synovial cyst 28.65 9.96 128 373545 8038 50223413
Acute respiratory failure 28.16 9.96 113 373560 28669 50202782
Tenosynovitis 28.08 9.96 153 373520 10412 50221039
Toxic skin eruption 28.06 9.96 25 373648 11226 50220225
Hypomagnesaemia 28.01 9.96 83 373590 23073 50208378
International normalised ratio increased 27.90 9.96 195 373478 42957 50188494
Blood pressure diastolic increased 27.90 9.96 119 373554 7324 50224127
Atrial fibrillation 27.67 9.96 557 373116 101188 50130263
Schizophrenia 27.65 9.96 10 373663 7387 50224064
Latent tuberculosis 27.58 9.96 55 373618 2188 50229263
Dyskinesia 27.50 9.96 109 373564 27752 50203699
Immune reconstitution inflammatory syndrome 27.45 9.96 4 373669 5512 50225939
Coagulopathy 27.43 9.96 57 373616 17887 50213564
Cerebrovascular accident 27.37 9.96 513 373160 94167 50137284
Device difficult to use 27.11 9.96 20 373653 9866 50221585
Gastrointestinal haemorrhage 26.92 9.96 380 373293 72941 50158510
Blood creatinine increased 26.82 9.96 398 373275 75762 50155689
Laryngitis 26.69 9.96 155 373518 10801 50220650
Wheelchair user 26.53 9.96 89 373584 4883 50226568
Dysmorphism 26.48 9.96 53 373620 2114 50229337
Irritability 26.32 9.96 114 373559 28312 50203139
Pulmonary hypertension 26.31 9.96 142 373531 33275 50198176
Eosinophilia 26.25 9.96 62 373611 18590 50212861
Melaena 25.95 9.96 106 373567 26758 50204693
Drug tolerance decreased 25.94 9.96 135 373538 9025 50222426
Metastases to central nervous system 25.89 9.96 27 373646 11255 50220196
Skin ulcer 25.78 9.96 385 373288 34933 50196518
Polyneuropathy 25.69 9.96 31 373642 12100 50219351
Arthritis infective 25.67 9.96 95 373578 5474 50225977
Skin papilloma 25.56 9.96 79 373594 4150 50227301
Crying 25.56 9.96 72 373601 20344 50211107
Bronchospasm 25.50 9.96 44 373629 14810 50216641
Parkinsonism 25.45 9.96 17 373656 8830 50222621
Obstructive airways disorder 25.40 9.96 48 373625 15604 50215847
Bradyphrenia 25.34 9.96 7 373666 6145 50225306
Malignant melanoma 25.28 9.96 144 373529 9964 50221487
Macular degeneration 25.27 9.96 42 373631 14346 50217105
Mania 25.19 9.96 26 373647 10890 50220561
Atrioventricular block complete 25.16 9.96 11 373662 7244 50224207
Ischaemic stroke 24.94 9.96 50 373623 15898 50215553
Pain in extremity 24.92 9.96 2339 371334 270526 49960925
Asphyxia 24.67 9.96 5 373668 5422 50226029
Back pain 24.57 9.96 1351 372322 218679 50012772
Jaundice 24.47 9.96 106 373567 26323 50205128
Transplant rejection 24.39 9.96 21 373652 9588 50221863
Neck mass 24.36 9.96 67 373606 3294 50228157
Stress cardiomyopathy 24.28 9.96 14 373659 7873 50223578
Oedema peripheral 24.27 9.96 937 372736 157024 50074427
Developmental hip dysplasia 24.08 9.96 38 373635 1253 50230198
Placental disorder 23.84 9.96 40 373633 1390 50230061
Thrombotic microangiopathy 23.83 9.96 18 373655 8773 50222678
Face oedema 23.77 9.96 61 373612 17778 50213673
Sepsis 23.73 9.96 774 372899 132151 50099300
Synovial fluid analysis 23.64 9.96 43 373630 1595 50229856
Device use error 23.63 9.96 5 373668 5261 50226190
Acute generalised exanthematous pustulosis 23.34 9.96 19 373654 8919 50222532
Abdominal distension 23.30 9.96 388 373285 72515 50158936
Fear 23.28 9.96 45 373628 14504 50216947
Aggression 23.22 9.96 79 373594 21037 50210414
Second primary malignancy 23.17 9.96 11 373662 6903 50224548
Paralysis 23.15 9.96 18 373655 8646 50222805
Tumour lysis syndrome 23.10 9.96 13 373660 7408 50224043
Hypomania 23.05 9.96 3 373670 4502 50226949
Pancreatitis acute 22.97 9.96 94 373579 23718 50207733
Myoclonus 22.94 9.96 45 373628 14425 50217026
Haematotoxicity 22.94 9.96 15 373658 7880 50223571
Spinal stenosis 22.90 9.96 175 373498 13375 50218076
Oropharyngeal pain 22.90 9.96 744 372929 77057 50154394
Febrile bone marrow aplasia 22.80 9.96 9 373664 6302 50225149
Blood potassium decreased 22.42 9.96 170 373503 36775 50194676
Product adhesion issue 22.29 9.96 3 373670 4389 50227062
Stomatitis 22.28 9.96 938 372735 100406 50131045
Accidental exposure to product 22.26 9.96 91 373582 22966 50208485
Rotator cuff repair 22.21 9.96 43 373630 1673 50229778
Acute myeloid leukaemia 22.11 9.96 49 373624 15025 50216426
Hypervolaemia 21.98 9.96 105 373568 25394 50206057
Graft versus host disease 21.94 9.96 9 373664 6157 50225294
Loose body in joint 21.88 9.96 35 373638 1168 50230283
Depressed mood 21.87 9.96 154 373519 33869 50197582
Muscular weakness 21.87 9.96 534 373139 94479 50136972
Pyrexia 21.82 9.96 2466 371207 377737 49853714
Polyhydramnios 21.78 9.96 47 373626 1978 50229473
Dystonia 21.71 9.96 34 373639 11892 50219559
Agranulocytosis 21.66 9.96 83 373590 21338 50210113
Abdominal pain 21.55 9.96 1478 372195 234750 49996701
Panic attack 21.51 9.96 72 373601 19270 50212181
Pulmonary tuberculosis 21.49 9.96 75 373598 4198 50227253
Product dose omission issue 21.41 9.96 1124 372549 182714 50048737
Hemiparesis 21.37 9.96 76 373597 19972 50211479
Postoperative wound infection 21.37 9.96 121 373552 8354 50223097
Miosis 21.21 9.96 10 373663 6300 50225151
Complication of device insertion 21.20 9.96 9 373664 6032 50225419
Therapeutic response decreased 21.15 9.96 477 373196 46754 50184697
Cardiac failure acute 20.98 9.96 18 373655 8232 50223219
Unevaluable event 20.96 9.96 228 373445 45838 50185613
Tardive dyskinesia 20.92 9.96 14 373659 7265 50224186
Gastroenteritis viral 20.65 9.96 221 373452 18565 50212886
Pancreatitis 20.58 9.96 208 373465 42406 50189045
Anhedonia 20.53 9.96 24 373649 9500 50221951
Substance abuse 20.50 9.96 3 373670 4121 50227330
Confusional state 20.50 9.96 1143 372530 184785 50046666
Body temperature decreased 20.48 9.96 198 373475 16197 50215254
Atrial septal defect 20.48 9.96 97 373576 6244 50225207
Lethargy 20.41 9.96 250 373423 49182 50182269
Uterine perforation 20.31 9.96 11 373662 6404 50225047
Cardiogenic shock 20.28 9.96 54 373619 15545 50215906
Cytopenia 20.14 9.96 21 373652 8754 50222697
Joint dislocation 20.13 9.96 158 373515 12175 50219276
Tachypnoea 20.08 9.96 49 373624 14528 50216923
COVID-19 20.03 9.96 234 373439 46428 50185023
Rash maculo-papular 19.99 9.96 115 373558 26526 50204925
Herpes zoster 19.83 9.96 673 373000 70113 50161338
Genital haemorrhage 19.77 9.96 12 373661 6562 50224889
Complication associated with device 19.61 9.96 50 373623 14605 50216846
Dementia 19.59 9.96 57 373616 15940 50215511
Body height below normal 19.57 9.96 44 373629 1905 50229546
Disease recurrence 19.54 9.96 79 373594 20002 50211449
Glycosylated haemoglobin increased 19.53 9.96 30 373643 10576 50220875
Hyperlipidaemia 19.53 9.96 65 373608 17425 50214026
Metastases to lung 19.51 9.96 32 373641 10988 50220463
Foetal death 19.46 9.96 115 373558 8065 50223386
Psychomotor hyperactivity 19.45 9.96 24 373649 9277 50222174
Acute graft versus host disease 19.40 9.96 3 373670 3955 50227496
Nervousness 19.36 9.96 122 373551 27529 50203922
Erythema multiforme 19.30 9.96 23 373650 9027 50222424
Acute chest syndrome 19.22 9.96 24 373649 633 50230818
Haemorrhage intracranial 19.17 9.96 39 373634 12335 50219116
Urinary retention 19.15 9.96 114 373559 26076 50205375
Injection site warmth 19.10 9.96 171 373502 13695 50217756
Stevens-Johnson syndrome 19.08 9.96 89 373584 21663 50209788
Red blood cell sedimentation rate 18.96 9.96 64 373609 3522 50227929
Headache 18.94 9.96 3372 370301 503163 49728288
Pemphigoid 18.89 9.96 10 373663 5897 50225554
Maternal exposure timing unspecified 18.61 9.96 64 373609 3556 50227895
Plasma cell myeloma 18.59 9.96 145 373528 31177 50200274
Foetal anticonvulsant syndrome 18.53 9.96 22 373651 550 50230901
Status epilepticus 18.52 9.96 45 373628 13361 50218090
Joint injury 18.51 9.96 244 373429 21545 50209906
Sinus tachycardia 18.36 9.96 88 373585 21266 50210185
Haemophagocytic lymphohistiocytosis 18.34 9.96 22 373651 8611 50222840
Subdural haematoma 18.25 9.96 43 373630 12904 50218547
Congenital arterial malformation 18.16 9.96 17 373656 320 50231131
Antinuclear antibody positive 18.15 9.96 93 373580 6179 50225272
Cholecystitis chronic 18.14 9.96 27 373646 9642 50221809
Joint noise 18.08 9.96 63 373610 3524 50227927
Fear of injection 18.02 9.96 91 373582 6012 50225439
Shock haemorrhagic 18.01 9.96 21 373652 8323 50223128
Crohn's disease 17.99 9.96 76 373597 4657 50226794
Oral herpes 17.99 9.96 233 373440 20492 50210959
Atrioventricular block 17.90 9.96 13 373660 6465 50224986
Clear cell renal cell carcinoma 17.90 9.96 32 373641 1171 50230280
Infusion site erythema 17.75 9.96 23 373650 8704 50222747
Leukocytosis 17.74 9.96 96 373577 22483 50208968
Haemorrhage in pregnancy 17.63 9.96 39 373634 1670 50229781
Dactylitis 17.56 9.96 41 373632 1820 50229631
Mood altered 17.55 9.96 43 373630 12730 50218721
Device related infection 17.51 9.96 86 373587 20649 50210802
Cushingoid 17.50 9.96 96 373577 6549 50224902
Synovial disorder 17.50 9.96 27 373646 873 50230578
Gestational hypertension 17.45 9.96 45 373628 2128 50229323
Scleritis 17.43 9.96 58 373615 3169 50228282
Exposure to toxic agent 17.42 9.96 3 373670 3655 50227796
Lupus-like syndrome 17.42 9.96 125 373548 9366 50222085
Infusion site pain 17.41 9.96 41 373632 12305 50219146
Skin cancer 17.40 9.96 124 373549 9270 50222181
Paradoxical drug reaction 17.35 9.96 3 373670 3644 50227807
Hallucination, auditory 17.32 9.96 33 373640 10695 50220756
Breast feeding 17.28 9.96 26 373647 822 50230629
Salivary hypersecretion 17.23 9.96 14 373659 6577 50224874
Incorrect route of product administration 17.20 9.96 75 373598 18591 50212860
Myocarditis 17.16 9.96 20 373653 7927 50223524
Labelled drug-drug interaction medication error 17.12 9.96 32 373641 10445 50221006
Hypertransaminasaemia 17.11 9.96 3 373670 3608 50227843
Stillbirth 17.05 9.96 88 373585 5864 50225587
Proteinuria 16.98 9.96 64 373609 16533 50214918
Lymphocyte count decreased 16.95 9.96 119 373554 26188 50205263
Acidosis 16.92 9.96 31 373642 10196 50221255
Ketoacidosis 16.87 9.96 4 373669 3891 50227560
Haematoma 16.85 9.96 144 373529 30366 50201085
Myopathy 16.69 9.96 26 373647 9113 50222338
Fracture 16.67 9.96 194 373479 16639 50214812
Complication of device removal 16.67 9.96 5 373668 4159 50227292
Talipes 16.58 9.96 34 373639 1380 50230071
Clostridium difficile colitis 16.52 9.96 71 373602 17671 50213780
Dry skin 16.51 9.96 222 373451 42969 50188482
Multiple allergies 16.50 9.96 23 373650 8440 50223011
Aphasia 16.41 9.96 133 373540 28361 50203090
Sleep apnoea syndrome 16.36 9.96 106 373567 23762 50207689
Haemoptysis 16.32 9.96 116 373557 25457 50205994
Hypophosphataemia 16.28 9.96 23 373650 8391 50223060
Dislocation of vertebra 16.24 9.96 55 373618 3032 50228419
Hepatotoxicity 16.18 9.96 126 373547 27100 50204351
Fracture delayed union 16.13 9.96 45 373628 2231 50229220
Immunodeficiency 16.10 9.96 174 373499 14654 50216797
Cardiomyopathy 16.01 9.96 60 373613 15526 50215925
Oedema 15.99 9.96 395 373278 69786 50161665
Tubulointerstitial nephritis 15.99 9.96 58 373615 15153 50216298
Off label use 15.93 9.96 3176 370497 471250 49760201
Wheezing 15.88 9.96 343 373330 61704 50169747
Mouth ulceration 15.84 9.96 293 373380 27731 50203720
Skin exfoliation 15.84 9.96 165 373508 33447 50198004
Respiration abnormal 15.79 9.96 9 373664 5093 50226358
Hypophagia 15.70 9.96 130 373543 27598 50203853
Hallucination, visual 15.66 9.96 66 373607 16516 50214935
Multiple sclerosis 15.63 9.96 88 373585 20405 50211046
Injection site haematoma 15.59 9.96 87 373586 5973 50225478
Pharyngitis streptococcal 15.59 9.96 115 373558 8693 50222758
Hyperprolactinaemia 15.51 9.96 3 373670 3362 50228089
Neonatal respiratory distress syndrome 15.50 9.96 49 373624 2605 50228846
Muscle twitching 15.47 9.96 60 373613 15371 50216080
Catheter site erythema 15.42 9.96 5 373668 3957 50227494
Bone marrow failure 15.42 9.96 130 373543 27494 50203957
Human antichimeric antibody positive 15.38 9.96 34 373639 1455 50229996
Generalised oedema 15.35 9.96 51 373622 13680 50217771
Diabetes mellitus 15.33 9.96 262 373411 48771 50182680
Temperature regulation disorder 15.32 9.96 6 373667 4221 50227230
Cerebral infarction 15.29 9.96 95 373578 21509 50209942
Angina pectoris 15.19 9.96 122 373551 26066 50205385
Poor venous access 15.01 9.96 129 373544 10211 50221240
Delusion 14.98 9.96 35 373638 10534 50220917
Pathogen resistance 14.97 9.96 12 373661 5677 50225774
Aspergillus infection 14.90 9.96 17 373656 6804 50224647
Rash erythematous 14.87 9.96 175 373498 34677 50196774
Affective disorder 14.84 9.96 10 373663 5171 50226280
Pulmonary congestion 14.83 9.96 60 373613 15187 50216264
Antibody test positive 14.74 9.96 44 373629 2267 50229184
Vascular device infection 14.65 9.96 7 373666 4377 50227074
Blood glucose decreased 14.55 9.96 77 373596 18134 50213317
Aspiration 14.52 9.96 29 373644 9235 50222216
Colitis microscopic 14.52 9.96 16 373657 6504 50224947
Infusion site swelling 14.50 9.96 19 373654 7157 50224294
Speech disorder developmental 14.45 9.96 20 373653 585 50230866
Gastrointestinal disorder 14.44 9.96 844 372829 93612 50137839
Bronchopulmonary aspergillosis 14.44 9.96 21 373652 7571 50223880
Oliguria 14.41 9.96 24 373649 8192 50223259
Muscle rigidity 14.38 9.96 32 373641 9797 50221654
Pseudomonas infection 14.37 9.96 30 373643 9400 50222051
Bone disorder 14.31 9.96 206 373467 18546 50212905
Exomphalos 14.30 9.96 19 373654 534 50230917
Squamous cell carcinoma 14.24 9.96 102 373571 7637 50223814
Polyuria 14.24 9.96 19 373654 7102 50224349
Cholestasis of pregnancy 14.23 9.96 28 373645 1103 50230348
Catheter site pain 14.21 9.96 5 373668 3757 50227694
Bundle branch block left 14.19 9.96 15 373658 6215 50225236
Malaise 14.19 9.96 2218 371455 333314 49898137
Tendonitis 14.16 9.96 187 373486 16518 50214933
Surgery 14.14 9.96 307 373366 29898 50201553
Device breakage 14.03 9.96 31 373642 9516 50221935
Pericardial effusion 14.03 9.96 121 373552 25468 50205983
Toxic epidermal necrolysis 14.00 9.96 94 373579 20898 50210553
Lip swelling 14.00 9.96 116 373557 24620 50206831
Cyanosis 13.99 9.96 61 373612 15123 50216328
Right ventricular failure 13.96 9.96 65 373608 15828 50215623
Product prescribing error 13.91 9.96 94 373579 20867 50210584
Blood iron increased 13.86 9.96 31 373642 1337 50230114
Joint lock 13.83 9.96 40 373633 2025 50229426
Anuria 13.82 9.96 40 373633 11204 50220247
Immunosuppression 13.74 9.96 98 373575 7328 50224123
Influenza 13.68 9.96 800 372873 88738 50142713
Autism spectrum disorder 13.54 9.96 21 373652 682 50230769
Foetal distress syndrome 13.51 9.96 29 373644 1216 50230235
Renal injury 13.46 9.96 27 373646 8584 50222867
Hypertelorism 13.45 9.96 16 373657 401 50231050
Anger 13.43 9.96 41 373632 11292 50220159
Dysuria 13.40 9.96 140 373533 28364 50203087
Sinus bradycardia 13.38 9.96 51 373622 13132 50218319
Abdominal pain upper 13.33 9.96 1004 372669 158305 50073146
Bundle branch block right 13.26 9.96 9 373664 4636 50226815
Induced labour 13.20 9.96 24 373649 890 50230561
Coronary artery disease 13.17 9.96 148 373525 29578 50201873
Hot flush 13.17 9.96 238 373435 43931 50187520
Urinary incontinence 13.08 9.96 139 373534 28069 50203382
Cervical incompetence 13.05 9.96 19 373654 583 50230868
Hallucinations, mixed 13.04 9.96 7 373666 4096 50227355
Tumour marker increased 13.04 9.96 6 373667 3834 50227617
Visual acuity reduced 13.02 9.96 91 373582 20048 50211403
Hepatic cytolysis 13.02 9.96 25 373648 8078 50223373
Colitis 12.99 9.96 203 373470 38326 50193125
Occult blood 12.97 9.96 28 373645 1179 50230272
Mental disorder 12.96 9.96 102 373571 21889 50209562
Ankylosing spondylitis 12.94 9.96 94 373579 7071 50224380
Wound infection 12.93 9.96 142 373531 12006 50219445
Tongue disorder 12.87 9.96 114 373559 9102 50222349
Personality disorder 12.86 9.96 8 373665 4316 50227135
Ulcer 12.77 9.96 215 373458 19985 50211466
Arthritis bacterial 12.66 9.96 78 373595 5551 50225900
Myelosuppression 12.64 9.96 54 373619 13463 50217988
Product substitution issue 12.64 9.96 57 373616 14000 50217451
Klebsiella infection 12.63 9.96 21 373652 7173 50224278
Joint warmth 12.60 9.96 30 373643 1349 50230102
Therapy change 12.57 9.96 12 373661 5213 50226238
Visual impairment 12.55 9.96 396 373277 67879 50163572
Lymphatic fistula 12.53 9.96 21 373652 729 50230722
Hereditary angioedema 12.51 9.96 13 373660 5429 50226022
Malignant mediastinal neoplasm 12.51 9.96 18 373655 546 50230905
Hyperthyroidism 12.42 9.96 47 373626 12128 50219323
Foot fracture 12.40 9.96 213 373460 19878 50211573
Paraesthesia 12.37 9.96 744 372929 119499 50111952
Purpura 12.37 9.96 35 373638 9876 50221575
Femoral hernia incarcerated 12.30 9.96 21 373652 740 50230711
Serum ferritin increased 12.29 9.96 73 373600 5129 50226322
Injection site irritation 12.24 9.96 64 373609 4286 50227165
Human anti-human antibody test 12.18 9.96 15 373658 390 50231061
Transplant dysfunction 12.18 9.96 10 373663 4674 50226777
Maternal exposure during breast feeding 12.17 9.96 52 373621 3202 50228249
Dermatitis exfoliative 12.15 9.96 12 373661 5130 50226321
Respiratory acidosis 12.14 9.96 16 373657 6012 50225439
Tendon disorder 12.13 9.96 74 373599 5248 50226203
Infusion site pruritus 12.11 9.96 7 373666 3930 50227521
Cardiac disorder 12.07 9.96 234 373439 42745 50188706
Drug abuser 12.06 9.96 3 373670 2825 50228626
Polydipsia 12.06 9.96 4 373669 3120 50228331
Acute pulmonary oedema 12.05 9.96 22 373651 7245 50224206
Patent ductus arteriosus 12.02 9.96 58 373615 3762 50227689
Trigeminal neuralgia 12.01 9.96 4 373669 3111 50228340
Pulseless electrical activity 11.99 9.96 20 373653 6821 50224630
Wound infection pseudomonas 11.96 9.96 28 373645 1245 50230206
Endodontic procedure 11.96 9.96 46 373627 2700 50228751
Pneumonia viral 11.95 9.96 20 373653 6814 50224637
Pancytopenia 11.94 9.96 746 372927 83284 50148167
Treatment noncompliance 11.88 9.96 154 373519 29996 50201455
Bronchitis 11.87 9.96 908 372765 103251 50128200
Product complaint 11.87 9.96 44 373629 11422 50220029
Abortion missed 11.85 9.96 32 373641 1556 50229895
Eating disorder 11.84 9.96 66 373607 15343 50216108
Product preparation error 11.79 9.96 9 373664 4363 50227088
Renal disorder 11.78 9.96 138 373535 27367 50204084
Epstein-Barr virus infection 11.76 9.96 21 373652 6976 50224475
Swollen tongue 11.74 9.96 145 373528 28485 50202966
Acute myocardial infarction 11.73 9.96 149 373524 29124 50202327
Systemic inflammatory response syndrome 11.68 9.96 12 373661 5037 50226414
Bone density abnormal 11.66 9.96 49 373624 2996 50228455
Drug-induced liver injury 11.63 9.96 142 373531 27953 50203498
Abortion threatened 11.57 9.96 17 373656 526 50230925
Lymphoedema 11.54 9.96 32 373641 9090 50222361
Multiple-drug resistance 11.53 9.96 5 373668 3309 50228142
Pregnancy with contraceptive device 11.51 9.96 8 373665 4071 50227380
Blood loss anaemia 11.50 9.96 27 373646 8112 50223339
Food allergy 11.49 9.96 27 373646 8110 50223341
Potentiating drug interaction 11.43 9.96 7 373666 3809 50227642
Ingrown hair 11.43 9.96 16 373657 473 50230978
Sexual dysfunction 11.40 9.96 5 373668 3287 50228164
Amylase increased 11.37 9.96 14 373659 5416 50226035
Pulmonary haemorrhage 11.36 9.96 19 373654 6473 50224978
Rheumatoid lung 11.32 9.96 42 373631 2423 50229028
Anterior chamber cleavage syndrome 11.32 9.96 10 373663 174 50231277
Learning disorder 11.27 9.96 18 373655 600 50230851
Knee operation 11.26 9.96 68 373605 4805 50226646
Crystal nephropathy 11.26 9.96 21 373652 794 50230657
Circulatory collapse 11.22 9.96 94 373579 19906 50211545
Renal tubular necrosis 11.21 9.96 38 373635 10130 50221321
Progressive multifocal leukoencephalopathy 11.20 9.96 45 373628 11412 50220039
Paranoia 11.18 9.96 39 373634 10309 50221142
Bone lesion 11.17 9.96 13 373660 5157 50226294
Intervertebral disc degeneration 11.13 9.96 150 373523 13311 50218140
Lung adenocarcinoma 11.07 9.96 60 373613 4074 50227377
Affect lability 11.07 9.96 32 373641 8966 50222485
Abnormal dreams 11.06 9.96 34 373639 9343 50222108
Somnambulism 11.06 9.96 12 373661 4912 50226539
Cardiotoxicity 11.01 9.96 22 373651 7005 50224446
Adverse event 11.00 9.96 411 373262 43352 50188099
Plasma cell myeloma recurrent 10.99 9.96 3 373670 2655 50228796
Catatonia 10.99 9.96 7 373666 3729 50227722
Nystagmus 10.96 9.96 15 373658 5546 50225905
Alanine aminotransferase abnormal 10.92 9.96 60 373613 4096 50227355
Presyncope 10.91 9.96 120 373553 24078 50207373
Forceps delivery 10.91 9.96 10 373663 183 50231268
Peripheral sensory neuropathy 10.88 9.96 20 373653 6571 50224880
Myofascial pain syndrome 10.86 9.96 37 373636 2046 50229405
Coronary arterial stent insertion 10.84 9.96 3 373670 2631 50228820
Haemodialysis 10.83 9.96 29 373644 8333 50223118
Product administered to patient of inappropriate age 10.82 9.96 3 373670 2627 50228824
Inflammatory marker increased 10.80 9.96 75 373598 5559 50225892
Bradykinesia 10.78 9.96 8 373665 3935 50227516
Hepatitis acute 10.78 9.96 27 373646 7934 50223517
Placental insufficiency 10.78 9.96 27 373646 1254 50230197
Carpal tunnel syndrome 10.76 9.96 180 373493 16713 50214738
Toxic encephalopathy 10.74 9.96 15 373658 5500 50225951
Chondropathy 10.68 9.96 37 373636 2063 50229388
Stress at work 10.64 9.96 24 373649 1041 50230410
Pleuritic pain 10.64 9.96 83 373590 6383 50225068
Troponin increased 10.63 9.96 28 373645 8090 50223361
Lymphadenectomy 10.58 9.96 22 373651 902 50230549
Nail injury 10.58 9.96 15 373658 449 50231002
Threatened labour 10.53 9.96 20 373653 767 50230684
Drug screen positive 10.53 9.96 6 373667 3396 50228055
Pancreatic steatosis 10.50 9.96 22 373651 907 50230544
Head injury 10.48 9.96 120 373553 23900 50207551
Abortion incomplete 10.44 9.96 5 373668 3121 50228330
Ankyloglossia congenital 10.44 9.96 10 373663 194 50231257
Eosinophil count increased 10.43 9.96 32 373641 8798 50222653
Haematocrit decreased 10.42 9.96 335 373338 34641 50196810
Vacuum extractor delivery 10.41 9.96 9 373664 152 50231299
Inadequate analgesia 10.37 9.96 3 373670 2555 50228896
Product physical issue 10.36 9.96 10 373663 4322 50227129
Congenital hydronephrosis 10.36 9.96 14 373659 400 50231051
Acute coronary syndrome 10.35 9.96 35 373638 9339 50222112
Chills 10.35 9.96 596 373077 96091 50135360
Embedded device 10.33 9.96 4 373669 2833 50228618
Retinitis 10.26 9.96 34 373639 1853 50229598
Lung transplant 10.25 9.96 4 373669 2821 50228630
Restless legs syndrome 10.20 9.96 72 373601 15825 50215626
Retrognathia 10.10 9.96 14 373659 410 50231041
Ileus paralytic 10.10 9.96 9 373664 4041 50227410
Ataxia 10.08 9.96 60 373613 13726 50217725
Rhinitis allergic 10.08 9.96 24 373649 7176 50224275
Osteoporotic fracture 10.08 9.96 48 373625 3097 50228354
Ear infection 10.02 9.96 257 373416 25713 50205738
Incorrect product administration duration 9.99 9.96 35 373638 9240 50222211
Pulmonary alveolar haemorrhage 9.98 9.96 9 373664 4018 50227433
Blood phosphorus decreased 9.96 9.96 8 373665 3781 50227670

FDA Adverse Event Reporting System (Male)

MedDRA adverse event termLikelihood ratioLikelihood ratio thresholdPatients taking drug having adverse eventPatients taking drug not having adverse eventPatients not taking drug having adverse eventPatients not taking drug not having adverse event
Rheumatoid arthritis 530.90 9.79 691 133456 31461 29408919
Foetal exposure during pregnancy 305.70 9.79 550 133597 33317 29407063
Drug abuse 296.87 9.79 16 134131 79867 29360513
Toxicity to various agents 223.24 9.79 276 133871 173385 29266995
Arthralgia 215.83 9.79 1222 132925 138395 29301985
Completed suicide 199.15 9.79 80 134067 90166 29350214
Psoriatic arthropathy 156.68 9.79 257 133890 14434 29425946
Dysmorphism 132.37 9.79 109 134038 2862 29437518
Drug interaction 116.74 9.79 480 133667 196905 29243475
Joint swelling 109.56 9.79 481 133666 49149 29391231
Sickle cell anaemia with crisis 108.56 9.79 92 134055 2516 29437864
Premature baby 103.71 9.79 237 133910 17043 29423337
Psoriasis 89.96 9.79 336 133811 31891 29408489
Enthesopathy 89.05 9.79 97 134050 3646 29436734
Exposure during pregnancy 86.32 9.79 146 134001 8408 29431972
Intentional overdose 81.96 9.79 36 134111 38492 29401888
Speech disorder developmental 78.82 9.79 67 134080 1840 29438540
Neonatal respiratory distress syndrome 74.17 9.79 89 134058 3721 29436659
Tenosynovitis 73.98 9.79 88 134059 3645 29436735
Blood pressure fluctuation 72.72 9.79 227 133920 19667 29420713
Musculoskeletal stiffness 70.81 9.79 347 133800 37111 29403269
Acute kidney injury 70.51 9.79 817 133330 264450 29175930
Atrial septal defect 67.35 9.79 115 134032 6674 29433706
Hypospadias 66.60 9.79 75 134072 2927 29437453
Foetal anticonvulsant syndrome 65.46 9.79 49 134098 1115 29439265
Nasopharyngitis 62.44 9.79 474 133673 59191 29381189
Pain 59.88 9.79 1101 133046 170331 29270049
Death 59.60 9.79 1144 133003 340940 29099440
Maternal drugs affecting foetus 58.54 9.79 80 134067 3813 29436567
Overdose 58.51 9.79 177 133970 79642 29360738
Synovitis 58.43 9.79 143 134004 10747 29429633
Drug reaction with eosinophilia and systemic symptoms 58.21 9.79 27 134120 27965 29412415
Maternal exposure during pregnancy 57.92 9.79 82 134065 4041 29436339
Autism spectrum disorder 57.91 9.79 58 134089 1974 29438406
Low birth weight baby 55.38 9.79 104 134043 6504 29433876
Small for dates baby 52.99 9.79 73 134074 3506 29436874
Product use in unapproved indication 52.65 9.79 209 133938 86666 29353714
C-reactive protein abnormal 52.47 9.79 101 134046 6435 29433945
Cryptorchism 50.93 9.79 53 134094 1889 29438491
Learning disorder 50.84 9.79 40 134107 982 29439398
Hypoglycaemia neonatal 50.59 9.79 50 134097 1674 29438706
Suicide attempt 50.58 9.79 48 134099 34062 29406318
Arthritis 48.15 9.79 233 133914 24786 29415594
Coma 47.16 9.79 66 134081 39384 29400996
Serotonin syndrome 46.70 9.79 11 134136 17501 29422879
Hepatic function abnormal 46.61 9.79 66 134081 39193 29401187
Tongue disorder 46.60 9.79 79 134068 4557 29435823
Ventricular septal defect 46.38 9.79 68 134079 3461 29436919
Maternal exposure during breast feeding 45.29 9.79 44 134103 1442 29438938
Drug resistance 44.44 9.79 21 134126 21519 29418861
Rhabdomyolysis 43.73 9.79 136 134011 60672 29379708
Foot deformity 42.47 9.79 70 134077 3945 29436435
Palmar-plantar erythrodysaesthesia syndrome 41.96 9.79 8 134139 14751 29425629
Arthropathy 40.24 9.79 199 133948 21355 29419025
Syndactyly 40.00 9.79 31 134116 744 29439636
Pulmonary fibrosis 39.81 9.79 158 133989 15424 29424956
Febrile neutropenia 39.27 9.79 323 133824 111917 29328463
Basal cell carcinoma 38.89 9.79 166 133981 16744 29423636
Rheumatoid nodule 38.76 9.79 48 134099 2074 29438306
Drug intolerance 38.72 9.79 362 133785 48017 29392363
Developmental delay 38.25 9.79 52 134095 2466 29437914
Haemoglobin decreased 37.75 9.79 696 133451 107679 29332701
Lower respiratory tract infection 37.56 9.79 227 133920 26275 29414105
Osteoarthritis 37.32 9.79 172 133975 17931 29422449
Blood pressure systolic increased 36.94 9.79 163 133984 16682 29423698
Exposure via breast milk 36.67 9.79 42 134105 1670 29438710
Pancytopenia 35.86 9.79 553 133594 82615 29357765
Intentional product misuse 35.73 9.79 64 134083 34597 29405783
Drug dependence 35.45 9.79 26 134121 20955 29419425
Infusion related reaction 34.93 9.79 328 133819 43558 29396822
Joint laxity 34.92 9.79 22 134125 374 29440006
Tendonitis 33.99 9.79 96 134051 7865 29432515
Congenital hand malformation 33.88 9.79 25 134122 556 29439824
Talipes 33.48 9.79 41 134106 1751 29438629
Alanine aminotransferase abnormal 33.25 9.79 53 134094 2904 29437476
Blood pressure increased 32.69 9.79 493 133654 73310 29367070
Bradycardia 32.51 9.79 170 133977 65459 29374921
Jaundice neonatal 32.44 9.79 34 134113 1222 29439158
Angioedema 31.95 9.79 60 134087 31855 29408525
Blood pressure systolic abnormal 31.88 9.79 44 134103 2117 29438263
Hypermobility syndrome 31.84 9.79 20 134127 338 29440042
Intellectual disability 31.57 9.79 32 134115 1105 29439275
Foetal growth restriction 31.22 9.79 59 134088 3707 29436673
Respiratory arrest 31.09 9.79 43 134104 25790 29414590
Pain in extremity 30.75 9.79 686 133461 109747 29330633
Renal failure 30.72 9.79 367 133780 118232 29322148
Language disorder 30.58 9.79 41 134106 1918 29438462
Delirium 29.84 9.79 86 134061 39311 29401069
Joint effusion 29.21 9.79 61 134086 4123 29436257
Cytomegalovirus infection 28.59 9.79 38 134109 23177 29417203
Large for dates baby 28.43 9.79 27 134120 860 29439520
Off label use 28.37 9.79 1097 133050 299703 29140677
Drug withdrawal syndrome 28.22 9.79 24 134123 17960 29422420
Polyarthritis 28.11 9.79 58 134089 3887 29436493
Hyperglycaemia 28.10 9.79 72 134075 34215 29406165
Plagiocephaly 27.93 9.79 21 134126 481 29439899
Serum ferritin increased 27.49 9.79 71 134076 5517 29434863
Peripheral swelling 27.15 9.79 423 133724 63316 29377064
Suicidal ideation 26.86 9.79 75 134072 34641 29405739
Somnolence 26.58 9.79 285 133862 93670 29346710
Hyperbilirubinaemia neonatal 26.51 9.79 24 134123 718 29439662
Cardiac failure 26.44 9.79 231 133916 79056 29361324
Hypoglycaemia 26.38 9.79 121 134026 48225 29392155
Loss of personal independence in daily activities 25.97 9.79 201 133946 25239 29415141
Skin cancer 25.91 9.79 91 134056 8377 29432003
Musculoskeletal pain 25.90 9.79 222 133925 28731 29411649
Knee deformity 25.87 9.79 21 134126 540 29439840
Knee arthroplasty 25.74 9.79 71 134076 5738 29434642
Constipation 25.61 9.79 364 133783 113796 29326584
Sedation 25.21 9.79 25 134122 17380 29423000
Caesarean section 25.19 9.79 37 134110 1886 29438494
Lactic acidosis 25.19 9.79 63 134084 30184 29410196
Hand deformity 25.09 9.79 39 134108 2091 29438289
Dysgraphia 24.96 9.79 38 134109 2000 29438380
Motor developmental delay 24.88 9.79 22 134125 638 29439742
Selective eating disorder 24.74 9.79 34 134113 1629 29438751
Astigmatism 24.46 9.79 26 134121 950 29439430
Behaviour disorder 24.41 9.79 52 134095 3564 29436816
Drug withdrawal syndrome neonatal 24.29 9.79 50 134097 3345 29437035
Agitation 24.24 9.79 135 134012 51169 29389211
Depressed level of consciousness 24.23 9.79 86 134061 36856 29403524
Multiple organ dysfunction syndrome 24.22 9.79 177 133970 62939 29377441
Disease progression 24.18 9.79 246 133901 81670 29358710
Psychotic disorder 23.39 9.79 35 134112 20319 29420061
Otitis media 23.27 9.79 42 134105 2547 29437833
Altered state of consciousness 23.05 9.79 34 134113 19855 29420525
Blood pressure diastolic decreased 22.83 9.79 77 134070 6945 29433435
Strabismus 22.67 9.79 30 134117 1386 29438994
Hypotonia neonatal 22.59 9.79 28 134119 1211 29439169
Body temperature decreased 22.48 9.79 102 134045 10562 29429818
Blood pressure diastolic abnormal 22.44 9.79 41 134106 2510 29437870
Cardiac arrest 22.09 9.79 265 133882 85326 29355054
Hydrocele 21.95 9.79 35 134112 1918 29438462
Pathogen resistance 21.84 9.79 5 134142 8111 29432269
Poisoning 21.78 9.79 9 134138 9984 29430396
C-reactive protein increased 21.70 9.79 301 133846 43962 29396418
Urticaria 21.60 9.79 152 133995 54508 29385872
Medical device implantation 21.34 9.79 19 134128 556 29439824
Crohn's disease 21.16 9.79 44 134103 2965 29437415
Agitation neonatal 21.10 9.79 25 134122 1031 29439349
Dyslexia 20.99 9.79 15 134132 317 29440063
Substance abuse 20.80 9.79 3 134144 6784 29433596
Heart rate decreased 20.72 9.79 188 133959 24724 29415656
Arthritis bacterial 20.61 9.79 55 134092 4358 29436022
Dyspraxia 20.61 9.79 16 134131 385 29439995
Anal fistula 20.32 9.79 53 134094 4142 29436238
Blood creatine phosphokinase increased 20.28 9.79 105 134042 40539 29399841
Wound 20.16 9.79 108 134039 11955 29428425
Juvenile idiopathic arthritis 19.99 9.79 28 134119 1366 29439014
Attention deficit hyperactivity disorder 19.97 9.79 36 134111 2181 29438199
Patent ductus arteriosus 19.96 9.79 44 134103 3087 29437293
Shock 19.91 9.79 42 134105 21362 29419018
Foetal disorder 19.87 9.79 21 134126 762 29439618
Congenital anomaly 19.53 9.79 27 134120 1301 29439079
Post procedural infection 19.45 9.79 53 134094 4252 29436128
Tuberculosis 19.22 9.79 74 134073 7122 29433258
Vitamin D deficiency 19.20 9.79 62 134085 5467 29434913
Psychomotor retardation 19.18 9.79 42 134105 2934 29437446
Colitis ulcerative 19.13 9.79 111 134036 12658 29427722
Lacrimal disorder 19.07 9.79 14 134133 309 29440071
Bronchiolitis 19.04 9.79 40 134107 2715 29437665
Renal aplasia 18.96 9.79 19 134128 647 29439733
Cleft lip 18.95 9.79 14 134133 312 29440068
Congenital bladder anomaly 18.81 9.79 13 134134 260 29440120
Limb reduction defect 18.76 9.79 13 134134 261 29440119
Renal impairment 18.70 9.79 258 133889 81075 29359305
Acute hepatic failure 18.69 9.79 16 134131 11936 29428444
Weight decrease neonatal 18.68 9.79 14 134133 319 29440061
Malignant melanoma 18.60 9.79 73 134074 7088 29433292
Congenital foot malformation 18.47 9.79 15 134132 386 29439994
Haematocrit decreased 18.36 9.79 207 133940 28815 29411565
Neuroleptic malignant syndrome 18.33 9.79 28 134119 16120 29424260
Blood pressure diastolic increased 18.30 9.79 47 134100 3639 29436741
Toxic epidermal necrolysis 18.28 9.79 34 134113 18119 29422261
Back disorder 18.11 9.79 64 134083 5909 29434471
Intentional self-injury 17.93 9.79 18 134129 12443 29427937
Ankyloglossia congenital 17.82 9.79 13 134134 284 29440096
Scoliosis 17.80 9.79 35 134112 2265 29438115
Nasal disorder 17.72 9.79 27 134120 1422 29438958
Hepatic failure 17.71 9.79 78 134069 31434 29408946
Injection site pain 17.71 9.79 225 133922 32221 29408159
Rash maculo-papular 17.68 9.79 54 134093 24235 29416145
Joint range of motion decreased 17.62 9.79 64 134083 5990 29434390
Diaphragmatic disorder 17.59 9.79 22 134125 960 29439420
Haemangioma congenital 17.56 9.79 16 134131 483 29439897
Joint stiffness 17.35 9.79 87 134060 9386 29430994
Lung neoplasm malignant 17.27 9.79 118 134029 14239 29426141
Inflammation 17.15 9.79 168 133979 22560 29417820
Electrocardiogram QT prolonged 17.11 9.79 95 134052 36042 29404338
Microcephaly 17.09 9.79 19 134128 731 29439649
Umbilical hernia 16.89 9.79 46 134101 3689 29436691
Multiple congenital abnormalities 16.89 9.79 16 134131 508 29439872
Hallucination 16.86 9.79 126 134021 44586 29395794
Bradycardia neonatal 16.75 9.79 21 134126 919 29439461
Arthrodesis 16.73 9.79 15 134132 443 29439937
Respiratory disorder neonatal 16.66 9.79 26 134121 1399 29438981
Weight decreased 16.55 9.79 840 133307 150065 29290315
Vitamin B12 deficiency 16.54 9.79 42 134105 3229 29437151
Grip strength decreased 16.53 9.79 34 134113 2273 29438107
Polydactyly 16.50 9.79 23 134124 1117 29439263
Infective pulmonary exacerbation of cystic fibrosis 16.46 9.79 4 134143 6232 29434148
Proteinuria 16.45 9.79 29 134118 15775 29424605
C-reactive protein decreased 16.35 9.79 27 134120 1524 29438856
Diabetic ketoacidosis 16.27 9.79 30 134117 16043 29424337
Pectus excavatum 16.26 9.79 11 134136 212 29440168
Status epilepticus 16.22 9.79 15 134132 10779 29429601
Spinal disorder 16.21 9.79 45 134102 3650 29436730
Red blood cell sedimentation rate increased 16.20 9.79 72 134075 7389 29432991
Septic arthritis staphylococcal 16.05 9.79 15 134132 468 29439912
Hypertelorism 16.01 9.79 16 134131 543 29439837
Respiratory rate increased 15.97 9.79 80 134067 8628 29431752
Ear disorder 15.95 9.79 24 134123 1250 29439130
Neck mass 15.91 9.79 26 134121 1455 29438925
Haemangioma 15.89 9.79 28 134119 1666 29438714
Cellulitis 15.80 9.79 294 133853 45546 29394834
Pyrexia 15.77 9.79 1108 133039 286514 29153866
Immunodeficiency 15.61 9.79 50 134097 4390 29435990
Ankylosing spondylitis 15.58 9.79 48 134099 4128 29436252
Oesophageal fibrosis 15.57 9.79 10 134137 176 29440204
Therapeutic product effect decreased 15.55 9.79 203 133944 29248 29411132
Infection 15.53 9.79 457 133690 76294 29364086
Poor venous access 15.38 9.79 40 134107 3121 29437259
Contraindicated product administered 15.27 9.79 138 134009 18128 29422252
Maternal exposure timing unspecified 15.17 9.79 13 134134 361 29440019
Neurotoxicity 15.04 9.79 27 134120 14586 29425794
Inguinal hernia 14.87 9.79 65 134082 6623 29433757
No adverse event 14.87 9.79 36 134111 17442 29422938
Arnold-Chiari malformation 14.80 9.79 12 134135 308 29440072
Prostate cancer 14.78 9.79 179 133968 25348 29415032
Emphysema 14.74 9.79 78 134069 8593 29431787
Oropharyngeal pain 14.69 9.79 200 133947 29085 29411295
Pneumonia 14.63 9.79 1662 132485 318510 29121870
Hernia pain 14.52 9.79 11 134136 255 29440125
Foetal distress syndrome 14.23 9.79 20 134127 979 29439401
Injection site bruising 14.15 9.79 70 134077 7510 29432870
Oxygen saturation decreased 14.05 9.79 284 133863 44653 29395727
Blood parathyroid hormone decreased 14.03 9.79 18 134129 806 29439574
Foetal heart rate deceleration abnormality 14.01 9.79 14 134133 475 29439905
Vascular insufficiency 13.98 9.79 12 134135 334 29440046
Venoocclusive liver disease 13.88 9.79 7 134140 6910 29433470
Ear infection 13.87 9.79 73 134074 8027 29432353
Pleural fibrosis 13.75 9.79 23 134124 1312 29439068
Diverticular perforation 13.75 9.79 37 134110 2947 29437433
Anal atresia 13.74 9.79 11 134136 277 29440103
Spina bifida 13.74 9.79 12 134135 342 29440038
Peripheral artery thrombosis 13.73 9.79 30 134117 2092 29438288
Unresponsive to stimuli 13.63 9.79 63 134084 25063 29415317
Mouth ulceration 13.60 9.79 87 134060 10268 29430112
Finger deformity 13.60 9.79 21 134126 1119 29439261
Tooth malformation 13.60 9.79 9 134138 167 29440213
Blood insulin increased 13.60 9.79 12 134135 347 29440033
Radiation inflammation 13.57 9.79 10 134137 222 29440158
Developmental coordination disorder 13.19 9.79 9 134138 176 29440204
Drug ineffective for unapproved indication 13.13 9.79 28 134119 14186 29426194
Cerebral haemorrhage 13.10 9.79 86 134061 31340 29409040
Ear malformation 13.07 9.79 11 134136 298 29440082
Congenital hydronephrosis 13.00 9.79 16 134131 687 29439693
Arthritis infective 12.99 9.79 35 134112 2789 29437591
Incorrect route of product administration 12.97 9.79 18 134129 10783 29429597
Haemolysis 12.82 9.79 64 134083 6892 29433488
Respiratory failure 12.77 9.79 339 133808 96792 29343588
Palindromic rheumatism 12.76 9.79 9 134138 186 29440194
Red blood cell sedimentation rate 12.56 9.79 14 134133 540 29439840
Product quality issue 12.55 9.79 34 134113 15861 29424519
Anaphylactic shock 12.54 9.79 26 134121 13310 29427070
Gangrene neonatal 12.52 9.79 9 134138 192 29440188
Hyperammonaemia 12.51 9.79 5 134142 5658 29434722
Kidney infection 12.38 9.79 48 134099 4635 29435745
Neonatal seizure 12.32 9.79 13 134134 471 29439909
Excessive cerumen production 12.29 9.79 10 134137 258 29440122
Pulmonary artery stenosis congenital 12.27 9.79 13 134134 473 29439907
Neonatal infection 12.16 9.79 12 134135 401 29439979
Lung cancer metastatic 12.11 9.79 31 134116 2396 29437984
Progressive multifocal leukoencephalopathy 12.09 9.79 13 134134 8706 29431674
Meningeal disorder 12.07 9.79 11 134136 332 29440048
Hepatic enzyme increased 12.07 9.79 218 133929 33581 29406799
Lipase increased 12.04 9.79 12 134135 8325 29432055
Cleft palate 11.96 9.79 14 134133 570 29439810
Nephrolithiasis 11.90 9.79 171 133976 25163 29415217
Non-Hodgkin's lymphoma 11.85 9.79 23 134124 1474 29438906
Neck pain 11.82 9.79 149 133998 21298 29419082
Osteonecrosis of jaw 11.81 9.79 37 134110 16473 29423907
Stevens-Johnson syndrome 11.78 9.79 37 134110 16460 29423920
Back pain 11.75 9.79 572 133575 101712 29338668
Irritability 11.75 9.79 56 134091 22096 29418284
Second primary malignancy 11.73 9.79 8 134139 6697 29433683
Vomiting 11.72 9.79 817 133330 211443 29228937
Cardiogenic shock 11.71 9.79 46 134101 19144 29421236
Aggression 11.64 9.79 104 134043 35437 29404943
Low set ears 11.59 9.79 12 134135 425 29439955
Malignant neoplasm progression 11.57 9.79 251 133896 73608 29366772
Steatorrhoea 11.57 9.79 15 134132 679 29439701
Sexual dysfunction 11.49 9.79 6 134141 5808 29434572
Educational problem 11.41 9.79 13 134134 514 29439866
Aspergillus infection 11.39 9.79 19 134128 10562 29429818
Synovial cyst 11.36 9.79 26 134121 1871 29438509
Fine motor skill dysfunction 11.28 9.79 23 134124 1528 29438852
Cholelithiasis 11.28 9.79 132 134015 18540 29421840
Wrong technique in product usage process 11.17 9.79 90 134057 31338 29409042
Foetal hypokinesia 11.16 9.79 11 134136 367 29440013
Decreased appetite 11.16 9.79 542 133605 144800 29295580
Lung neoplasm 11.08 9.79 44 134103 4296 29436084
Pharyngeal disorder 10.98 9.79 14 134133 623 29439757
Dermatitis psoriasiform 10.92 9.79 19 134128 1119 29439261
Tonsil cancer 10.90 9.79 17 134130 914 29439466
Localised infection 10.85 9.79 103 134044 13713 29426667
Abnormal behaviour 10.84 9.79 61 134086 23066 29417314
Oesophageal atresia 10.80 9.79 12 134135 461 29439919
Pancreatic duct stenosis 10.80 9.79 8 134139 179 29440201
Granuloma skin 10.79 9.79 14 134133 634 29439746
Acute chest syndrome 10.73 9.79 10 134137 311 29440069
Sinusitis 10.71 9.79 217 133930 34133 29406247
Joint instability 10.66 9.79 11 134136 388 29439992
Skin lesion 10.65 9.79 130 134017 18442 29421938
Moaning 10.64 9.79 15 134132 736 29439644
Neutropenia neonatal 10.64 9.79 14 134133 643 29439737
Hypoxia 10.63 9.79 151 133996 47228 29393152
Chronic obstructive pulmonary disease 10.63 9.79 252 133895 40703 29399677
Mean cell volume increased 10.61 9.79 30 134117 2459 29437921
Maternal exposure before pregnancy 10.58 9.79 12 134135 472 29439908
Nose deformity 10.54 9.79 8 134139 186 29440194
Hypertriglyceridaemia 10.53 9.79 11 134136 7464 29432916
Hepatocellular injury 10.52 9.79 55 134092 21188 29419192
Dysgeusia 10.52 9.79 60 134087 22614 29417766
Tachycardia 10.52 9.79 249 133898 72161 29368219
Agranulocytosis 10.45 9.79 52 134095 20288 29420092
Pulmonary tuberculosis 10.42 9.79 43 134104 4272 29436108
Transfusion-related circulatory overload 10.36 9.79 8 134139 191 29440189
Mesothelioma 10.35 9.79 11 134136 402 29439978
Retinopathy hypertensive 10.32 9.79 9 134138 256 29440124
Psychomotor skills impaired 10.31 9.79 31 134116 2630 29437750
Disseminated intravascular coagulation 10.31 9.79 51 134096 19929 29420451
Skin graft failure 10.26 9.79 7 134140 137 29440243
Congenital diaphragmatic hernia 10.18 9.79 9 134138 261 29440119
Obsessive-compulsive disorder 10.17 9.79 4 134143 4572 29435808
Necrotising fasciitis streptococcal 10.17 9.79 7 134140 139 29440241
Myoclonus 10.11 9.79 29 134118 13280 29427100
Mucosal ulceration 10.10 9.79 16 134131 872 29439508
Glycosylated haemoglobin increased 10.08 9.79 17 134130 9409 29430971
Hypermetropia 10.06 9.79 11 134136 415 29439965
Gross motor delay 10.06 9.79 9 134138 265 29440115
Placental insufficiency 10.06 9.79 6 134141 92 29440288
Pharyngitis 10.01 9.79 60 134087 6923 29433457
Pyelocaliectasis 9.98 9.79 18 134129 1091 29439289
Blood test abnormal 9.97 9.79 52 134095 5697 29434683
Appendix disorder 9.95 9.79 13 134134 593 29439787
Injection site swelling 9.94 9.79 75 134072 9342 29431038
Heart rate irregular 9.91 9.79 97 134050 13020 29427360
Respiratory depression 9.89 9.79 30 134117 13493 29426887
Folate deficiency 9.89 9.79 18 134129 1099 29439281
Tachycardia foetal 9.87 9.79 9 134138 272 29440108
Withdrawal syndrome 9.86 9.79 22 134125 10970 29429410
Chronic graft versus host disease 9.86 9.79 3 134144 4026 29436354
Hepatic siderosis 9.83 9.79 7 134140 147 29440233
Ulna fracture 9.83 9.79 10 134137 347 29440033
Suspected suicide 9.82 9.79 3 134144 4017 29436363

FDA Adverse Event Reporting System (Geriatric)

MedDRA adverse event termLikelihood ratioLikelihood ratio thresholdPatients taking drug having adverse eventPatients taking drug not having adverse eventPatients not taking drug having adverse eventPatients not taking drug not having adverse event
Rheumatoid arthritis 1304.89 9.74 2942 376430 161352 63958008
Completed suicide 872.20 9.74 138 379234 224276 63895084
Pemphigus 837.42 9.74 1375 377997 59326 64060034
Arthropathy 828.96 9.74 2046 377326 118921 64000439
Systemic lupus erythematosus 812.65 9.74 1558 377814 76054 64043306
Joint swelling 806.53 9.74 2941 376431 212441 63906919
Hand deformity 775.95 9.74 1354 378018 61417 64057943
Synovitis 755.40 9.74 1747 377625 97343 64022017
Toxicity to various agents 720.69 9.74 647 378725 362866 63756494
Glossodynia 706.03 9.74 1322 378050 63374 64055986
Arthralgia 690.43 9.74 4705 374667 437555 63681805
Maternal exposure during pregnancy 652.71 9.74 1618 377754 94266 64025094
Infusion related reaction 627.28 9.74 2260 377112 162207 63957153
Drug abuse 606.03 9.74 45 379327 132329 63987031
Anti-cyclic citrullinated peptide antibody positive 583.95 9.74 1047 378325 48515 64070845
Wound 571.38 9.74 1338 378034 75139 64044221
Pericarditis 550.48 9.74 1168 378204 61348 64058012
Pain 507.08 9.74 5224 374148 548287 63571073
Abdominal discomfort 467.98 9.74 2218 377154 180104 63939256
Alopecia 437.13 9.74 2032 377340 163658 63955702
Swelling 410.99 9.74 1949 377423 158269 63961091
Therapeutic product effect decreased 406.72 9.74 1546 377826 113805 64005555
Contraindicated product administered 405.06 9.74 1475 377897 106354 64013006
Nasopharyngitis 402.58 9.74 2241 377131 193832 63925528
Discomfort 390.44 9.74 1204 378168 79674 64039686
Drug interaction 384.60 9.74 988 378384 361095 63758265
Rheumatoid factor positive 349.15 9.74 688 378684 34250 64085110
Drug intolerance 342.52 9.74 2082 377290 185910 63933450
Death 341.79 9.74 1569 377803 481136 63638224
Duodenal ulcer perforation 337.78 9.74 675 378697 33950 64085410
Helicobacter infection 336.75 9.74 716 378656 37646 64081714
Exposure during pregnancy 333.68 9.74 1111 378261 76564 64042796
Musculoskeletal stiffness 312.35 9.74 1494 377878 121712 63997648
Hepatic enzyme increased 306.09 9.74 1543 377829 128400 63990960
Intentional overdose 300.08 9.74 79 379293 89865 64029495
Acute kidney injury 264.47 9.74 1555 377817 447685 63671675
Psoriatic arthropathy 253.83 9.74 691 378681 42590 64076770
C-reactive protein abnormal 246.72 9.74 535 378837 28512 64090848
Sinusitis 231.61 9.74 1561 377811 144367 63974993
Impaired healing 225.91 9.74 826 378546 59647 64059713
Febrile neutropenia 225.42 9.74 479 378893 187178 63932182
Overdose 216.28 9.74 379 378993 159187 63960173
Lower respiratory tract infection 206.42 9.74 1100 378272 93514 64025846
Product use issue 202.64 9.74 1557 377815 150158 63969202
Red blood cell sedimentation rate abnormal 199.08 9.74 350 379022 15956 64103404
Peripheral swelling 198.55 9.74 1991 377381 207162 63912198
Cardiac arrest 195.43 9.74 381 378991 153683 63965677
Hypersensitivity 194.70 9.74 1887 377485 194565 63924795
Treatment failure 190.98 9.74 1259 378113 115557 64003803
Muscle injury 183.79 9.74 450 378922 25987 64093373
Blood pressure fluctuation 183.30 9.74 696 378676 51175 64068185
Depressed level of consciousness 178.31 9.74 131 379241 81305 64038055
Arthritis 175.75 9.74 964 378408 82850 64036510
Sickle cell anaemia with crisis 172.95 9.74 184 379188 5148 64114212
Drug ineffective 172.93 9.74 6296 373076 833951 63285409
Folliculitis 168.22 9.74 472 378900 29605 64089755
Suicide attempt 167.81 9.74 105 379267 70902 64048458
Sleep disorder due to general medical condition, insomnia type 162.67 9.74 428 378944 25842 64093518
Hip arthroplasty 160.90 9.74 375 378997 20976 64098384
Knee arthroplasty 160.23 9.74 433 378939 26566 64092794
Irritable bowel syndrome 159.95 9.74 534 378838 36835 64082525
Bradycardia 158.16 9.74 283 379089 117936 64001424
Weight increased 149.46 9.74 1914 377458 211434 63907926
Psoriasis 147.17 9.74 820 378552 70883 64048477
Drug reaction with eosinophilia and systemic symptoms 144.36 9.74 69 379303 54148 64065212
Respiratory arrest 143.28 9.74 66 379306 52919 64066441
Pregnancy 139.59 9.74 350 379022 20515 64098845
Rhabdomyolysis 138.24 9.74 203 379169 91523 64027837
Blister 136.78 9.74 880 378492 80087 64039273
Osteoarthritis 133.79 9.74 730 378642 62606 64056754
Abortion spontaneous 132.29 9.74 386 378986 24757 64094603
Lactic acidosis 131.59 9.74 101 379271 61309 64058051
Cardiac failure 130.58 9.74 374 378998 131999 63987361
Renal failure 128.48 9.74 590 378782 181098 63938262
Injection site erythema 124.85 9.74 778 378594 70022 64049338
Sedation 122.88 9.74 45 379327 41417 64077943
Infection 122.50 9.74 1642 377730 183238 63936122
Hepatic function abnormal 121.74 9.74 119 379253 64194 64055166
Sopor 117.91 9.74 17 379355 29644 64089716
Malignant neoplasm progression 117.22 9.74 311 379061 112560 64006800
Ill-defined disorder 110.65 9.74 533 378839 43519 64075841
Disease progression 109.99 9.74 444 378928 141236 63978124
Red blood cell sedimentation rate increased 109.42 9.74 418 378954 30817 64088543
Enthesopathy 107.60 9.74 199 379173 9439 64109921
Contusion 106.61 9.74 1082 378290 112883 64006477
Serotonin syndrome 106.11 9.74 49 379323 39233 64080127
Constipation 105.78 9.74 852 378520 228485 63890875
Blood pressure systolic increased 105.12 9.74 571 378801 48882 64070478
Injection site pruritus 101.83 9.74 467 378905 37359 64082001
Injection site pain 99.60 9.74 1048 378324 110360 64009000
Hypoglycaemia 99.28 9.74 240 379132 89652 64029708
Neutropenia 97.74 9.74 919 378453 238705 63880655
Drug resistance 97.62 9.74 42 379330 35060 64084300
Hyponatraemia 97.12 9.74 495 378877 147844 63971516
Fatigue 97.02 9.74 5354 374018 743376 63375984
Agitation 95.97 9.74 238 379134 88129 64031231
Joint effusion 95.41 9.74 231 379141 13242 64106118
Hypotension 94.81 9.74 1623 377749 379351 63740009
Condition aggravated 94.09 9.74 2861 376511 369565 63749795
Respiratory failure 93.96 9.74 559 378813 160624 63958736
Multiple organ dysfunction syndrome 93.91 9.74 295 379077 101118 64018242
Blood pressure diastolic abnormal 92.75 9.74 212 379160 11705 64107655
Juvenile idiopathic arthritis 92.22 9.74 114 379258 3765 64115595
Hepatic failure 92.16 9.74 114 379258 55280 64064080
Cytomegalovirus infection 92.12 9.74 52 379320 37147 64082213
Live birth 91.31 9.74 203 379169 11001 64108359
Drug dependence 90.84 9.74 41 379331 33271 64086089
Blood pressure systolic abnormal 88.88 9.74 187 379185 9755 64109605
Osteoporosis 88.17 9.74 484 378888 41596 64077764
Renal impairment 88.13 9.74 451 378921 134566 63984794
Pain in extremity 87.47 9.74 2368 377004 300717 63818643
Product use in unapproved indication 87.11 9.74 644 378728 175974 63943386
Hyperglycaemia 86.99 9.74 140 379232 60828 64058532
Rheumatic fever 86.82 9.74 178 379194 9116 64110244
Coma 86.78 9.74 247 379125 87368 64031992
Rash 86.36 9.74 3405 375967 455144 63664216
Intentional product misuse 86.34 9.74 185 379187 72110 64047250
Injection site reaction 85.55 9.74 518 378854 46146 64073214
Rheumatoid nodule 85.45 9.74 213 379159 12438 64106922
Somnolence 83.89 9.74 779 378593 202866 63916494
Disability assessment scale score increased 83.29 9.74 88 379284 2442 64116918
Cardio-respiratory arrest 83.04 9.74 298 379074 98095 64021265
Injection site swelling 81.58 9.74 468 378904 40885 64078475
Musculoskeletal pain 80.96 9.74 782 378590 80512 64038848
Tenosynovitis 80.73 9.74 200 379172 11633 64107727
Fibromyalgia 80.32 9.74 419 378953 35312 64084048
Swollen joint count increased 79.94 9.74 154 379218 7535 64111825
Electrocardiogram QT prolonged 79.40 9.74 223 379149 79225 64040135
Blood pressure diastolic decreased 79.39 9.74 300 379072 22001 64097359
Grip strength decreased 78.77 9.74 197 379175 11527 64107833
Caesarean section 77.39 9.74 191 379181 11083 64108277
Intentional self-injury 77.26 9.74 37 379335 29007 64090353
Foot deformity 74.34 9.74 240 379132 16264 64103096
Palmar-plantar erythrodysaesthesia syndrome 73.23 9.74 39 379333 28780 64090580
Heart rate decreased 71.68 9.74 562 378810 54505 64064855
Poisoning 71.47 9.74 20 379352 21859 64097501
Blood pressure increased 71.03 9.74 1417 377955 171135 63948225
Hypoxia 70.45 9.74 273 379099 87876 64031484
Joint laxity 70.05 9.74 77 379295 2237 64117123
Device expulsion 69.64 9.74 19 379353 21117 64098243
Disseminated intravascular coagulation 69.55 9.74 53 379319 32295 64087065
Drug withdrawal syndrome 68.91 9.74 50 379322 31241 64088119
C-reactive protein increased 68.71 9.74 857 378515 94052 64025308
Joint stiffness 68.66 9.74 357 379015 30047 64089313
Tachycardia 67.86 9.74 558 378814 149021 63970339
Delirium 67.84 9.74 196 379176 68998 64050362
Localised infection 67.32 9.74 353 379019 29808 64089552
Altered state of consciousness 66.26 9.74 75 379297 37827 64081533
Inflammation 65.43 9.74 629 378743 64671 64054689
Encephalopathy 64.97 9.74 157 379215 58662 64060698
Gastrointestinal disorder 64.92 9.74 810 378562 88899 64030461
Shock 64.35 9.74 78 379294 38162 64081198
Neoplasm progression 64.34 9.74 88 379284 40876 64078484
Injection site bruising 64.29 9.74 400 378972 35973 64083387
Loss of personal independence in daily activities 63.99 9.74 680 378692 71774 64047586
Bone erosion 62.91 9.74 180 379192 11415 64107945
Respiratory depression 62.15 9.74 30 379342 23413 64095947
Basal cell carcinoma 62.14 9.74 351 379021 30487 64088873
Polyarthritis 60.87 9.74 159 379213 9556 64109804
Immune reconstitution inflammatory syndrome 60.76 9.74 3 379369 12467 64106893
Gestational diabetes 60.63 9.74 114 379258 5476 64113884
Thrombocytopenia 59.33 9.74 942 378430 222859 63896501
Femur fracture 58.85 9.74 373 378999 33762 64085598
Tongue disorder 58.39 9.74 180 379192 11900 64107460
Syncope 58.21 9.74 619 378753 157016 63962344
Neuropathy peripheral 58.17 9.74 428 378944 117097 64002263
Blood creatine phosphokinase increased 58.04 9.74 165 379207 58393 64060967
Metabolic acidosis 57.19 9.74 219 379153 70739 64048621
Cardiac failure congestive 57.03 9.74 492 378880 130088 63989272
Cholestasis 56.82 9.74 111 379261 44761 64074599
Oropharyngeal pain 56.62 9.74 784 378588 88083 64031277
Mydriasis 55.94 9.74 11 379361 15301 64104059
Blood pressure diastolic increased 55.53 9.74 164 379208 10588 64108772
Angioedema 55.01 9.74 183 379189 61638 64057722
Anaemia 54.11 9.74 1756 377616 376924 63742436
Cognitive disorder 54.03 9.74 156 379216 54931 64064429
Stomatitis 53.75 9.74 925 378447 108680 64010680
Cerebral haemorrhage 53.60 9.74 140 379232 50950 64068410
Diabetic ketoacidosis 53.33 9.74 58 379314 29787 64089573
Hyperhidrosis 53.08 9.74 474 378898 124446 63994914
Tendonitis 52.81 9.74 248 379124 20034 64099326
Tremor 52.75 9.74 587 378785 147643 63971717
Hepatocellular injury 52.15 9.74 118 379254 45117 64074243
Acute hepatic failure 52.14 9.74 46 379326 26066 64093294
Premature delivery 51.89 9.74 232 379140 18357 64101003
Body temperature decreased 51.51 9.74 294 379078 25634 64093726
Injection site rash 50.54 9.74 205 379167 15537 64103823
Nodule 50.11 9.74 224 379148 17723 64101637
Pulmonary fibrosis 49.97 9.74 324 379048 29554 64089806
Disturbance in attention 49.96 9.74 104 379268 40970 64078390
Hallucination 49.85 9.74 239 379133 72549 64046811
Vomiting 48.94 9.74 2697 376675 548420 63570940
Hypothermia 48.81 9.74 28 379344 19828 64099532
Neuroleptic malignant syndrome 48.76 9.74 45 379327 24951 64094409
Herpes zoster 47.40 9.74 691 378681 78496 64040864
Synovial cyst 47.13 9.74 125 379247 7582 64111778
Tenderness 46.94 9.74 234 379138 19368 64099992
Joint destruction 46.93 9.74 80 379292 3556 64115804
Pre-eclampsia 46.46 9.74 109 379263 6122 64113238
Fracture 46.42 9.74 226 379146 18529 64100831
Sedation complication 46.01 9.74 4 379368 10350 64109010
Hyperkalaemia 45.97 9.74 377 378995 100752 64018608
Maternal exposure before pregnancy 45.44 9.74 77 379295 3406 64115954
Neck deformity 45.09 9.74 53 379319 1659 64117701
Myalgia 44.62 9.74 660 378712 157957 63961403
Abnormal behaviour 44.48 9.74 81 379291 33541 64085819
Disability 44.37 9.74 165 379207 12007 64107353
Infective pulmonary exacerbation of cystic fibrosis 44.11 9.74 8 379364 11788 64107572
Brain oedema 43.95 9.74 39 379333 22036 64097324
Hypokalaemia 43.66 9.74 482 378890 121421 63997939
Joint range of motion decreased 43.59 9.74 227 379145 19116 64100244
Mental status changes 43.55 9.74 198 379174 60964 64058396
Restlessness 43.30 9.74 107 379265 39678 64079682
Anxiety 43.26 9.74 886 378486 201763 63917597
Red blood cell sedimentation rate 43.12 9.74 78 379294 3636 64115724
Asthenia 42.86 9.74 2069 377303 425975 63693385
Speech disorder 42.68 9.74 144 379228 48297 64071063
Myoclonus 42.51 9.74 51 379321 25067 64094293
Alanine aminotransferase abnormal 42.41 9.74 112 379260 6776 64112584
Ventricular tachycardia 42.32 9.74 86 379286 34179 64085181
Joint injury 42.22 9.74 255 379117 22692 64096668
Myocardial infarction 41.93 9.74 704 378668 165117 63954243
Premature rupture of membranes 41.41 9.74 77 379295 3667 64115693
Seizure 41.40 9.74 711 378661 166181 63953179
Skin ulcer 41.33 9.74 418 378954 43556 64075804
Premature labour 41.06 9.74 118 379254 7502 64111858
Neurotoxicity 40.93 9.74 61 379311 27343 64092017
Limb deformity 40.84 9.74 72 379300 3289 64116071
Disorientation 40.79 9.74 179 379193 55649 64063711
Irritability 40.64 9.74 98 379274 36648 64082712
Laryngitis 40.60 9.74 150 379222 10881 64108479
Orthostatic hypotension 40.46 9.74 140 379232 46598 64072762
Dizziness 40.40 9.74 2093 377279 428070 63691290
Unresponsive to stimuli 40.30 9.74 156 379216 50237 64069123
Poor venous access 40.10 9.74 162 379210 12255 64107105
Dyspnoea 39.86 9.74 3663 375709 715011 63404349
Diarrhoea 39.73 9.74 3686 375686 719018 63400342
Neck mass 39.62 9.74 79 379293 3965 64115395
Bronchitis 39.51 9.74 877 378495 107866 64011494
Respiratory distress 39.33 9.74 166 379206 52165 64067195
Multiple sclerosis relapse 39.24 9.74 118 379254 41017 64078343
Venoocclusive liver disease 39.21 9.74 6 379366 10009 64109351
Tuberculosis 38.89 9.74 166 379206 12872 64106488
Cytokine release syndrome 38.88 9.74 39 379333 20790 64098570
Dehydration 38.82 9.74 974 378398 215789 63903571
Leukopenia 38.81 9.74 394 378978 100848 64018512
Oral herpes 38.76 9.74 243 379129 21909 64097451
Ventricular fibrillation 38.75 9.74 50 379322 23810 64095550
Smear cervix abnormal 38.56 9.74 58 379314 2316 64117044
Anaphylactic shock 38.42 9.74 75 379297 30253 64089107
Posterior reversible encephalopathy syndrome 38.40 9.74 47 379325 22899 64096461
Blood glucose increased 38.29 9.74 380 378992 97693 64021667
Neutrophil count decreased 38.25 9.74 281 379091 76915 64042445
Arthritis infective 38.01 9.74 109 379263 6921 64112439
Decreased appetite 37.88 9.74 1314 378058 279975 63839385
Influenza 37.71 9.74 856 378516 105675 64013685
Substance abuse 37.70 9.74 5 379367 9287 64110073
Pulmonary arterial hypertension 37.37 9.74 57 379315 25310 64094050
Ejection fraction decreased 37.23 9.74 70 379302 28637 64090723
Pulmonary embolism 36.79 9.74 622 378750 145734 63973626
Bone disorder 36.61 9.74 195 379177 16564 64102796
Cardiogenic shock 36.25 9.74 86 379286 32341 64087019
Extrapyramidal disorder 36.05 9.74 37 379335 19515 64099845
Latent tuberculosis 36.04 9.74 61 379311 2696 64116664
Spinal stenosis 36.02 9.74 170 379202 13761 64105599
Melaena 35.98 9.74 177 379195 53371 64065989
Multiple fractures 35.96 9.74 97 379275 5943 64113417
Status epilepticus 35.59 9.74 45 379327 21618 64097742
Immunodeficiency 35.49 9.74 188 379184 15936 64103424
Blood creatinine increased 35.46 9.74 573 378799 135209 63984151
Urticaria 35.45 9.74 631 378741 146686 63972674
Psychotic disorder 35.33 9.74 96 379276 34482 64084878
Fear of injection 35.26 9.74 95 379277 5817 64113543
Aggression 35.15 9.74 146 379226 46086 64073274
Therapeutic response decreased 35.12 9.74 465 378907 51723 64067637
Fluid retention 35.08 9.74 206 379166 59400 64059960
Suicidal ideation 35.03 9.74 238 379134 66304 64053056
Drug level increased 34.89 9.74 95 379277 34101 64085259
Pathogen resistance 34.89 9.74 15 379357 12528 64106832
Psychomotor hyperactivity 34.64 9.74 21 379351 14430 64104930
Skin cancer 34.60 9.74 151 379221 11823 64107537
Accidental overdose 34.41 9.74 93 379279 33464 64085896
Nausea 34.25 9.74 4074 375298 781726 63337634
Mouth ulceration 34.23 9.74 316 379056 32128 64087232
Torsade de pointes 34.17 9.74 31 379341 17332 64102028
Product quality issue 34.13 9.74 78 379294 29721 64089639
Wheelchair user 34.04 9.74 81 379291 4591 64114769
Ascites 34.03 9.74 219 379153 61782 64057578
Pancytopenia 33.97 9.74 1093 378279 142216 63977144
Second primary malignancy 33.92 9.74 15 379357 12322 64107038
Inappropriate antidiuretic hormone secretion 33.89 9.74 49 379323 22240 64097120
Aspergillus infection 33.75 9.74 28 379344 16351 64103009
Rash maculo-papular 33.62 9.74 152 379220 46874 64072486
Cerebral infarction 33.50 9.74 126 379246 40918 64078442
Surgery 33.49 9.74 282 379090 27931 64091429
Tenosynovitis stenosans 33.43 9.74 49 379323 1911 64117449
Ear infection 33.34 9.74 244 379128 23160 64096200
Arrhythmia 33.32 9.74 179 379193 52765 64066595
Proteinuria 33.04 9.74 71 379301 27652 64091708
Blood cholesterol increased 32.82 9.74 444 378928 49622 64069738
Gastrointestinal haemorrhage 32.70 9.74 564 378808 131748 63987612
Asphyxia 32.66 9.74 8 379364 9558 64109802
Skin papilloma 32.44 9.74 85 379287 5118 64114242
Agranulocytosis 32.10 9.74 116 379256 38113 64081247
Bradyphrenia 31.86 9.74 8 379364 9398 64109962
Gastroenteritis viral 31.81 9.74 212 379160 19517 64099843
Atrial fibrillation 31.65 9.74 765 378607 170324 63949036
Drug ineffective for unapproved indication 31.38 9.74 87 379285 31046 64088314
Malignant melanoma 31.21 9.74 155 379217 12809 64106551
Balance disorder 31.19 9.74 329 379043 83597 64035763
Bronchopulmonary aspergillosis 30.99 9.74 40 379332 19045 64100315
No adverse event 30.93 9.74 77 379295 28484 64090876
Intentional product use issue 30.91 9.74 757 378615 94607 64024753
Ischaemic stroke 30.89 9.74 79 379293 28956 64090404
Transplant rejection 30.89 9.74 34 379338 17367 64101993
Withdrawal syndrome 30.71 9.74 57 379315 23435 64095925
Joint noise 30.59 9.74 62 379310 3149 64116211
Haematotoxicity 30.55 9.74 19 379353 12877 64106483
Product administration error 30.35 9.74 74 379298 27569 64091791
Injection site warmth 30.34 9.74 158 379214 13304 64106056
Akathisia 30.10 9.74 15 379357 11495 64107865
Emotional distress 29.83 9.74 110 379262 35928 64083432
Foot fracture 29.82 9.74 196 379176 17961 64101399
Vision blurred 29.66 9.74 364 379008 89952 64029408
Mobility decreased 29.52 9.74 687 378685 85153 64034207
Miosis 29.47 9.74 21 379351 13245 64106115
Coagulopathy 29.43 9.74 93 379279 31827 64087533
Synovial fluid analysis 29.37 9.74 41 379331 1528 64117832
Asthma 29.33 9.74 389 378983 94836 64024524
Rotator cuff repair 29.31 9.74 40 379332 1459 64117901
Tachypnoea 29.28 9.74 71 379301 26500 64092860
Gamma-glutamyltransferase increased 28.89 9.74 167 379205 48343 64071017
Unintentional medical device removal 28.87 9.74 3 379369 6731 64112629
Blood parathyroid hormone decreased 28.67 9.74 102 379270 7264 64112096
Acute respiratory failure 28.63 9.74 174 379198 49760 64069600
Shock haemorrhagic 28.51 9.74 34 379338 16757 64102603
Ulcer 28.47 9.74 232 379140 22758 64096602
Acute graft versus host disease 28.40 9.74 9 379363 9075 64110285
Foetal death 28.32 9.74 88 379284 5842 64113518
Rhinorrhoea 27.91 9.74 502 378870 59467 64059893
Maternal exposure timing unspecified 27.87 9.74 54 379318 2653 64116707
Subdural haematoma 27.83 9.74 79 379293 27975 64091385
BK virus infection 27.77 9.74 5 379367 7407 64111953
Loose body in joint 27.68 9.74 35 379337 1183 64118177
Coronary artery disease 27.59 9.74 225 379147 60208 64059152
Tumour lysis syndrome 27.39 9.74 45 379327 19395 64099965
Eosinophilia 27.26 9.74 123 379249 37953 64081407
Forced expiratory volume decreased 27.14 9.74 4 379368 6863 64112497
Muscle spasms 27.07 9.74 627 378745 140396 63978964
Haemoptysis 27.04 9.74 173 379199 48875 64070485
Acute chest syndrome 26.90 9.74 30 379342 886 64118474
Pulmonary oedema 26.63 9.74 315 379057 78359 64041001
Hypertransaminasaemia 26.62 9.74 5 379367 7186 64112174
Oxygen saturation decreased 26.60 9.74 822 378550 106354 64013006
Osteonecrosis of jaw 26.55 9.74 132 379240 39693 64079667
Anaphylactic reaction 26.40 9.74 267 379105 68397 64050963
Fear 26.32 9.74 49 379323 20122 64099238
Dysarthria 26.29 9.74 223 379149 59183 64060177
Dystonia 26.27 9.74 44 379328 18821 64100539
Respiratory disorder 26.25 9.74 116 379256 35995 64083365
Post procedural infection 26.20 9.74 119 379253 9478 64109882
Loss of consciousness 26.19 9.74 668 378704 147697 63971663
Haemorrhage intracranial 26.17 9.74 64 379308 23820 64095540
Blood alkaline phosphatase increased 25.93 9.74 209 379163 56070 64063290
Thrombotic microangiopathy 25.93 9.74 36 379336 16619 64102741
Chronic kidney disease 25.82 9.74 217 379155 57702 64061658
Graft versus host disease 25.63 9.74 26 379346 13787 64105573
Antinuclear antibody positive 25.58 9.74 88 379284 6162 64113198
Erythema multiforme 25.40 9.74 33 379339 15668 64103692
Postoperative wound infection 25.18 9.74 124 379248 10212 64109148
Blood bilirubin increased 25.04 9.74 217 379155 57336 64062024
Toxic skin eruption 25.02 9.74 47 379325 19237 64100123
Sepsis 24.89 9.74 1104 378268 229237 63890123
Toxic epidermal necrolysis 24.88 9.74 123 379249 37043 64082317
Hyperthermia 24.83 9.74 33 379339 15517 64103843
Fracture delayed union 24.74 9.74 43 379329 1942 64117418
Creatinine renal clearance decreased 24.70 9.74 29 379343 14392 64104968
Leukocytosis 24.64 9.74 126 379246 37614 64081746
Clostridium difficile colitis 24.62 9.74 80 379292 27143 64092217
Mania 24.57 9.74 36 379336 16250 64103110
Granuloma skin 24.40 9.74 85 379287 5989 64113371
Cerebrovascular accident 24.40 9.74 619 378753 136964 63982396
Dysgeusia 24.40 9.74 169 379203 46878 64072482
Panniculitis 24.17 9.74 110 379262 8769 64110591
Haemorrhage 24.13 9.74 325 379047 79026 64040334
Pleural effusion 23.92 9.74 564 378808 125995 63993365
Deep vein thrombosis 23.89 9.74 455 378917 104727 64014633
Acute respiratory distress syndrome 23.75 9.74 133 379239 38802 64080558
Polyhydramnios 23.68 9.74 36 379336 1451 64117909
Glycosylated haemoglobin increased 23.59 9.74 36 379336 15983 64103377
Acidosis 23.42 9.74 43 379329 17752 64101608
Scleritis 23.34 9.74 53 379319 2913 64116447
Acute generalised exanthematous pustulosis 23.31 9.74 29 379343 14029 64105331
Drug hypersensitivity 23.06 9.74 1153 378219 236662 63882698
Face oedema 22.93 9.74 72 379300 24689 64094671
Drug use disorder 22.87 9.74 4 379368 6050 64113310
Joint dislocation 22.77 9.74 130 379242 11335 64108025
White blood cell count decreased 22.70 9.74 731 378641 157106 63962254
Jaundice 22.42 9.74 180 379192 48332 64071028
Hyperbilirubinaemia 22.32 9.74 58 379314 21147 64098213
Stillbirth 22.29 9.74 59 379313 3574 64115786
Adverse event 22.22 9.74 341 379031 39148 64080212
Dyskinesia 22.19 9.74 138 379234 39250 64080110
Hypomagnesaemia 22.08 9.74 129 379243 37247 64082113
Pyrexia 22.07 9.74 2914 376458 555730 63563630
Bursitis 22.03 9.74 208 379164 21277 64098083
Stevens-Johnson syndrome 21.99 9.74 115 379257 34134 64085226
Pharyngitis streptococcal 21.85 9.74 105 379267 8563 64110797
Platelet count decreased 21.73 9.74 787 378585 166924 63952436
Aphasia 21.68 9.74 146 379226 40760 64078600
Vertigo 21.65 9.74 232 379140 58779 64060581
Dactylitis 21.61 9.74 40 379332 1898 64117462
Hyperammonaemia 21.58 9.74 16 379356 9888 64109472
Bronchospasm 21.55 9.74 61 379311 21621 64097739
Haemoglobin decreased 21.30 9.74 1375 377997 193688 63925672
Synovial disorder 21.17 9.74 27 379345 921 64118439
Endodontic procedure 21.12 9.74 44 379328 2279 64117081
Febrile bone marrow aplasia 21.09 9.74 21 379351 11234 64108126
Acute graft versus host disease in skin 21.07 9.74 7 379365 6848 64112512
Cardiac failure acute 21.06 9.74 40 379332 16304 64103056
Wrong technique in product usage process 20.90 9.74 263 379109 64711 64054649
Potentiating drug interaction 20.89 9.74 10 379362 7842 64111518
Pulmonary alveolar haemorrhage 20.88 9.74 16 379356 9722 64109638
Cyanosis 20.81 9.74 64 379308 22091 64097269
Pneumatosis intestinalis 20.78 9.74 3 379369 5226 64114134
Breast feeding 20.77 9.74 23 379349 674 64118686
Pulmonary tuberculosis 20.66 9.74 91 379281 7153 64112207
Weight decreased 20.61 9.74 1950 377422 283789 63835571
Lipase increased 20.60 9.74 33 379339 14369 64104991
Pancreatitis 20.42 9.74 238 379134 59369 64059991
Normal newborn 20.35 9.74 76 379296 5541 64113819
Hyperuricaemia 20.29 9.74 18 379354 10173 64109187
Pemphigoid 20.29 9.74 28 379344 12958 64106402
Respiration abnormal 20.21 9.74 6 379366 6309 64113051
Stress cardiomyopathy 20.11 9.74 15 379357 9242 64110118
Depression 20.10 9.74 877 378495 182414 63936946
Incorrect route of product administration 20.02 9.74 70 379302 23228 64096132
Dyspnoea exertional 19.96 9.74 309 379063 73421 64045939
Hallucination, visual 19.87 9.74 90 379282 27744 64091616
Exostosis 19.72 9.74 125 379247 11313 64108047
Lupus-like syndrome 19.69 9.74 103 379269 8688 64110672
Hepatic encephalopathy 19.68 9.74 61 379311 21005 64098355
Adenovirus infection 19.67 9.74 9 379363 7246 64112114
Sinus tachycardia 19.61 9.74 110 379262 32078 64087282
Acute myeloid leukaemia 19.49 9.74 89 379283 27374 64091986
Haemophagocytic lymphohistiocytosis 19.44 9.74 47 379325 17562 64101798
Exposure to toxic agent 19.44 9.74 6 379366 6153 64113207
Human antichimeric antibody positive 19.40 9.74 32 379340 1384 64117976
Endophthalmitis 19.30 9.74 4 379368 5361 64113999
Dermatitis acneiform 19.24 9.74 13 379359 8430 64110930
Device use error 19.21 9.74 7 379365 6464 64112896
Aspartate aminotransferase increased 19.14 9.74 547 378825 119241 64000119
Rebound effect 19.12 9.74 3 379369 4914 64114446
Cushingoid 19.09 9.74 92 379280 7511 64111849
Foetal distress syndrome 19.09 9.74 18 379354 434 64118926
Polyneuropathy 19.02 9.74 57 379315 19837 64099523
Muscle rigidity 19.01 9.74 47 379325 17426 64101934
Haemorrhage in pregnancy 19.00 9.74 30 379342 1250 64118110
Tooth infection 18.98 9.74 149 379223 14452 64104908
Dry eye 18.87 9.74 257 379115 28762 64090598
Mass 18.83 9.74 154 379218 15122 64104238
Nightmare 18.77 9.74 62 379310 20931 64098429
Induced labour 18.74 9.74 24 379348 822 64118538
Cyst 18.65 9.74 128 379244 11899 64107461
Tardive dyskinesia 18.53 9.74 16 379356 9162 64110198
Metastases to bone 18.51 9.74 60 379312 20375 64098985
Klebsiella infection 18.47 9.74 31 379341 13250 64106110
Pancreatitis acute 18.46 9.74 162 379210 42693 64076667
Ingrown hair 18.45 9.74 20 379352 572 64118788
Delusion 18.41 9.74 50 379322 17964 64101396
Haematocrit decreased 18.35 9.74 436 378936 54219 64065141
Nocardiosis 18.34 9.74 3 379369 4764 64114596
Cytomegalovirus viraemia 18.31 9.74 22 379350 10806 64108554
Chronic graft versus host disease 18.28 9.74 7 379365 6269 64113091
Placental disorder 18.21 9.74 24 379348 846 64118514
Musculoskeletal disorder 18.18 9.74 173 379199 17733 64101627
Pulmonary hypertension 18.17 9.74 164 379208 42975 64076385
Anhedonia 18.14 9.74 33 379339 13673 64105687
Hallucination, auditory 18.09 9.74 46 379326 16893 64102467
Polyuria 18.06 9.74 29 379343 12614 64106746
Spinal disorder 18.05 9.74 100 379272 8622 64110738
Muscle spasticity 18.00 9.74 45 379327 16624 64102736
Colitis ulcerative 17.99 9.74 211 379161 22817 64096543
Injection site urticaria 17.94 9.74 120 379252 11061 64108299
Angina pectoris 17.87 9.74 174 379198 44907 64074453
Bone pain 17.87 9.74 186 379186 47386 64071974
Labelled drug-drug interaction medication error 17.83 9.74 68 379304 21994 64097366
Lacrimal disorder 17.83 9.74 18 379354 473 64118887
Polydipsia 17.79 9.74 6 379366 5815 64113545
Frequent bowel movements 17.68 9.74 175 379197 18130 64101230
Arthritis bacterial 17.67 9.74 92 379280 7747 64111613
Flushing 17.62 9.74 341 379031 78307 64041053
Progressive multifocal leukoencephalopathy 17.60 9.74 52 379320 18180 64101180
Tubulointerstitial nephritis 17.56 9.74 108 379264 30801 64088559
Pleuritic pain 17.55 9.74 94 379278 8002 64111358
Heart rate irregular 17.51 9.74 242 379130 27171 64092189
Cardiomyopathy 17.50 9.74 83 379289 25273 64094087
Dislocation of vertebra 17.44 9.74 49 379323 3075 64116285
Cellulitis 17.42 9.74 695 378677 92962 64026398
Tooth abscess 17.38 9.74 140 379232 13686 64105674
Chest discomfort 17.35 9.74 535 378837 115571 64003789
Cytopenia 17.31 9.74 41 379331 15430 64103930
Bone density abnormal 17.27 9.74 45 379327 2700 64116660
Drug-induced liver injury 17.20 9.74 188 379184 47455 64071905
Body height below normal 17.20 9.74 35 379337 1783 64117577
Cystitis haemorrhagic 17.15 9.74 13 379359 7943 64111417
Pain in jaw 17.14 9.74 155 379217 40600 64078760
Urinary retention 17.03 9.74 196 379176 49005 64070355
Sinus bradycardia 16.96 9.74 73 379299 22820 64096540
Anuria 16.96 9.74 56 379316 18908 64100452
Toothache 16.90 9.74 167 379205 17292 64102068
Oliguria 16.82 9.74 38 379334 14538 64104822
Upper respiratory tract infection 16.69 9.74 553 378819 72232 64047128
Placental insufficiency 16.68 9.74 25 379347 995 64118365
Gestational hypertension 16.66 9.74 33 379339 1648 64117712
Hyperlactacidaemia 16.64 9.74 4 379368 4840 64114520
Injection site haemorrhage 16.61 9.74 217 379155 24061 64095299
Acute coronary syndrome 16.60 9.74 58 379314 19252 64100108
Affective disorder 16.58 9.74 9 379363 6571 64112789
Device difficult to use 16.47 9.74 20 379352 9778 64109582
Immunosuppression 16.45 9.74 114 379258 10632 64108728
Blood pressure decreased 16.32 9.74 384 378988 85815 64033545
International normalised ratio increased 16.32 9.74 348 379024 78819 64040541
Wound infection pseudomonas 16.30 9.74 31 379341 1502 64117858
Type 2 diabetes mellitus 16.26 9.74 286 379086 33734 64085626
Sexual dysfunction 16.09 9.74 9 379363 6462 64112898
Tooth disorder 16.08 9.74 202 379170 22200 64097160
Cystitis 16.07 9.74 346 379026 42329 64077031
Insomnia 16.06 9.74 976 378396 196860 63922500
Tuberculin test positive 16.04 9.74 47 379325 3021 64116339
Lymphatic fistula 16.00 9.74 21 379351 737 64118623
Dysphagia 16.00 9.74 492 378880 106320 64013040
Chest pain 16 9.74 1183 378189 234797 63884563
Femoral hernia incarcerated 15.94 9.74 21 379351 740 64118620
Arthropod bite 15.93 9.74 80 379292 6641 64112719
Metastases to lung 15.88 9.74 42 379330 15222 64104138
Atrioventricular block 15.84 9.74 29 379343 11986 64107374
Maternal exposure during breast feeding 15.84 9.74 36 379336 1980 64117380
Hemiplegia 15.80 9.74 32 379340 12736 64106624
Wound infection 15.79 9.74 145 379227 14719 64104641
Epstein-Barr virus infection 15.71 9.74 31 379341 12457 64106903
Pulseless electrical activity 15.71 9.74 32 379340 12707 64106653
Cardiac failure chronic 15.68 9.74 18 379354 9023 64110337
Blood lactic acid increased 15.68 9.74 23 379349 10378 64108982
Gastric haemorrhage 15.67 9.74 35 379337 13446 64105914
Renal injury 15.64 9.74 43 379329 15386 64103974
Off label use 15.61 9.74 3388 375984 629418 63489942
Metastases to liver 15.59 9.74 80 379292 23861 64095499
Kidney infection 15.55 9.74 167 379205 17671 64101689
Sciatica 15.53 9.74 185 379187 20079 64099281
Coronary arterial stent insertion 15.53 9.74 7 379365 5685 64113675
Atrioventricular block complete 15.51 9.74 39 379333 14379 64104981
Septic shock 15.47 9.74 487 378885 104950 64014410
Cervical incompetence 15.44 9.74 17 379355 495 64118865
Peripheral sensory neuropathy 15.42 9.74 27 379345 11351 64108009
Joint lock 15.41 9.74 44 379328 2787 64116573
Electrocardiogram QRS complex prolonged 15.40 9.74 19 379353 9225 64110135
Obstructive airways disorder 15.36 9.74 77 379295 23108 64096252
Pulmonary haemorrhage 15.27 9.74 34 379338 13075 64106285
Hypoalbuminaemia 15.26 9.74 53 379319 17621 64101739
Hepatitis fulminant 15.20 9.74 9 379363 6265 64113095
Clear cell renal cell carcinoma 15.04 9.74 37 379335 2142 64117218
Injection site discolouration 15.02 9.74 80 379292 6795 64112565
Iodine allergy 15.01 9.74 17 379355 511 64118849
Injection site extravasation 14.97 9.74 90 379282 7996 64111364
Haematoma 14.95 9.74 187 379185 46063 64073297
Rheumatoid lung 14.95 9.74 40 379332 2439 64116921
Hypophosphataemia 14.94 9.74 41 379331 14679 64104681
Malignant mediastinal neoplasm 14.85 9.74 17 379355 517 64118843
Alcohol abuse 14.83 9.74 5 379367 4847 64114513
Visual acuity reduced 14.82 9.74 96 379276 27045 64092315
Sickle cell anaemia 14.81 9.74 18 379354 584 64118776
Acute myocardial infarction 14.80 9.74 305 379067 69413 64049947
Nephropathy toxic 14.80 9.74 53 379319 17461 64101899
Aphthous ulcer 14.79 9.74 128 379244 12778 64106582
Abortion threatened 14.74 9.74 15 379357 398 64118962
Antibody test positive 14.68 9.74 39 379333 2368 64116992
Pharyngitis 14.67 9.74 174 379198 18865 64100495
Hypervolaemia 14.66 9.74 149 379223 38136 64081224
Catatonia 14.53 9.74 14 379358 7606 64111754
Disease recurrence 14.52 9.74 117 379255 31393 64087967
Ankle arthroplasty 14.52 9.74 22 379350 884 64118476
Red blood cell count decreased 14.47 9.74 380 378992 48006 64071354
Anger 14.41 9.74 46 379326 15695 64103665
Knee operation 14.36 9.74 59 379313 4498 64114862
Palpitations 14.29 9.74 487 378885 104001 64015359
Joint warmth 14.28 9.74 28 379344 1388 64117972
Cholestasis of pregnancy 14.18 9.74 22 379350 903 64118457
Adjustment disorder with depressed mood 14.17 9.74 39 379333 2418 64116942
Hyperthyroidism 14.07 9.74 57 379315 18122 64101238
Tendon disorder 14.05 9.74 74 379298 6258 64113102
Small for dates baby 13.97 9.74 15 379357 424 64118936
Myopathy 13.96 9.74 55 379317 17625 64101735
Eye infection 13.93 9.74 98 379274 9183 64110177
Finger deformity 13.93 9.74 64 379308 5122 64114238
Nephrolithiasis 13.92 9.74 346 379026 43337 64076023
Muscle twitching 13.82 9.74 61 379311 18937 64100423
Hepatitis acute 13.81 9.74 37 379335 13352 64106008
Transaminases increased 13.79 9.74 182 379190 44412 64074948
Pneumothorax 13.75 9.74 85 379287 24213 64095147
Breast abscess 13.73 9.74 24 379348 1089 64118271
Ileus 13.71 9.74 79 379293 22887 64096473
Respiratory acidosis 13.71 9.74 23 379349 9832 64109528
Hypercapnia 13.69 9.74 15 379357 7679 64111681
Human anti-human antibody test 13.68 9.74 14 379358 374 64118986
Palindromic rheumatism 13.66 9.74 13 379359 317 64119043
C-reactive protein decreased 13.64 9.74 35 379337 2081 64117279
Paralysis 13.57 9.74 30 379342 11565 64107795
Toxic encephalopathy 13.57 9.74 23 379349 9792 64109568
Temperature regulation disorder 13.48 9.74 4 379368 4207 64115153
Foot operation 13.48 9.74 55 379317 4180 64115180
Myocarditis 13.47 9.74 53 379319 16990 64102370
Cytomegalovirus chorioretinitis 13.46 9.74 6 379366 4906 64114454
Hernia 13.43 9.74 130 379242 13388 64105972
Dyslipidaemia 13.39 9.74 21 379351 9221 64110139
Lymphocyte count decreased 13.37 9.74 164 379208 40535 64078825
Foetal exposure during pregnancy 13.36 9.74 57 379315 4419 64114941
Enterocolitis 13.33 9.74 32 379340 11986 64107374
Bacteraemia 13.31 9.74 98 379274 26813 64092547
Osteoporotic fracture 13.30 9.74 49 379323 3549 64115811
Ileus paralytic 13.29 9.74 18 379354 8397 64110963
Right ventricular failure 13.28 9.74 73 379299 21398 64097962
Pulmonary congestion 13.28 9.74 84 379288 23796 64095564
Pseudomonas infection 13.27 9.74 57 379315 17826 64101534
Presyncope 13.26 9.74 137 379235 34952 64084408
Interstitial lung disease 13.25 9.74 456 378916 97276 64022084
Oesophageal fibrosis 13.22 9.74 10 379362 176 64119184
Delivery 13.21 9.74 16 379356 517 64118843
Metastases to central nervous system 13.20 9.74 40 379332 13872 64105488
End stage renal disease 13.18 9.74 26 379346 10449 64108911
Hemiparesis 13.18 9.74 112 379260 29715 64089645
Drug abuser 13.16 9.74 9 379363 5799 64113561
Blood calcium decreased 13.15 9.74 92 379280 25462 64093898
Blood loss anaemia 13.14 9.74 40 379332 13852 64105508
Lip swelling 13.14 9.74 122 379250 31785 64087575
Stress at work 13.08 9.74 22 379350 967 64118393
Bradypnoea 13.08 9.74 7 379365 5152 64114208
Serum ferritin increased 13.06 9.74 90 379282 8378 64110982
Hepatitis cholestatic 12.98 9.74 33 379339 12122 64107238
Lung transplant 12.97 9.74 4 379368 4104 64115256
Retinitis 12.94 9.74 34 379338 2051 64117309
Myofascial pain syndrome 12.92 9.74 31 379341 1767 64117593
Increased tendency to bruise 12.90 9.74 96 379276 9159 64110201
Abortion missed 12.83 9.74 24 379348 1148 64118212
Drug specific antibody 12.83 9.74 34 379338 2061 64117299
Coordination abnormal 12.83 9.74 45 379327 14919 64104441
Drug screen positive 12.82 9.74 9 379363 5720 64113640
Product prescribing error 12.80 9.74 139 379233 35130 64084230
Anal fistula 12.78 9.74 63 379309 5190 64114170
Pancreatic steatosis 12.78 9.74 22 379350 986 64118374
Blood folate increased 12.75 9.74 15 379357 470 64118890
Feeling abnormal 12.70 9.74 649 378723 132953 63986407
Hypocalcaemia 12.69 9.74 171 379201 41582 64077778
Postpartum haemorrhage 12.68 9.74 27 379345 1420 64117940
Bradykinesia 12.57 9.74 12 379360 6548 64112812
Incoherent 12.53 9.74 14 379358 7104 64112256
Abdominal distension 12.53 9.74 450 378922 95544 64023816
Skin ulcer haemorrhage 12.53 9.74 15 379357 479 64118881
Graft versus host disease in skin 12.50 9.74 8 379364 5339 64114021
Therapy non-responder 12.48 9.74 490 378882 65409 64053951
Threatened labour 12.47 9.74 16 379356 549 64118811
Osteopenia 12.41 9.74 143 379229 15397 64103963
Ankylosing spondylitis 12.40 9.74 87 379285 8147 64111213
Pneumonia bacterial 12.37 9.74 46 379326 14989 64104371
Hypernatraemia 12.33 9.74 34 379338 12155 64107205
Skin laceration 12.30 9.74 207 379165 24210 64095150
Chondropathy 12.29 9.74 36 379336 2313 64117047
Hepatocellular carcinoma 12.26 9.74 19 379353 8384 64110976
Lip blister 12.19 9.74 35 379337 2224 64117136
Plasma cell myeloma 12.16 9.74 194 379178 45881 64073479
Hospitalisation 12.12 9.74 343 379029 74864 64044496
Skin neoplasm excision 12.11 9.74 20 379352 866 64118494
Intracranial pressure increased 12.03 9.74 14 379358 6975 64112385
Hepatotoxicity 12.03 9.74 164 379208 39798 64079562
Transplant dysfunction 12.02 9.74 13 379359 6695 64112665
Oligohydramnios 11.94 9.74 43 379329 3081 64116279
Uterine perforation 11.93 9.74 10 379362 5810 64113550
Spinal osteoarthritis 11.92 9.74 133 379239 14208 64105152
Mean cell volume increased 11.91 9.74 60 379312 4986 64114374
Sinus congestion 11.85 9.74 141 379231 15298 64104062
Cholangitis 11.79 9.74 29 379343 10773 64108587
Eosinophil count increased 11.73 9.74 43 379329 14069 64105291
Hepatitis C 11.69 9.74 30 379342 10985 64108375
Labyrinthitis 11.68 9.74 38 379334 2585 64116775
Cardiotoxicity 11.68 9.74 27 379345 10247 64109113
Virologic failure 11.64 9.74 3 379369 3463 64115897
Colitis microscopic 11.63 9.74 16 379356 7416 64111944
Cataract 11.63 9.74 389 378983 50873 64068487
Heparin-induced thrombocytopenia 11.60 9.74 20 379352 8459 64110901
Purpura 11.59 9.74 57 379315 17189 64102171
Swollen joint count 11.55 9.74 16 379356 592 64118768
Hypotonia 11.55 9.74 31 379341 11181 64108179
Sudden death 11.53 9.74 70 379302 20026 64099334
Peritoneal dialysis complication 11.52 9.74 34 379338 2194 64117166
Lower respiratory tract congestion 11.52 9.74 41 379331 2920 64116440
Skin graft failure 11.51 9.74 10 379362 216 64119144
Skin necrosis 11.51 9.74 132 379240 14197 64105163
Vacuum extractor delivery 11.49 9.74 8 379364 123 64119237
Erectile dysfunction 11.49 9.74 37 379335 12590 64106770
Generalised tonic-clonic seizure 11.49 9.74 165 379207 39692 64079668
Mesothelioma 11.44 9.74 12 379360 330 64119030
Alanine aminotransferase increased 11.44 9.74 685 378687 138346 63981014
Schizophrenia 11.41 9.74 31 379341 11137 64108223
Nail injury 11.40 9.74 14 379358 459 64118901
Amylase increased 11.38 9.74 25 379347 9660 64109700
Taste disorder 11.37 9.74 24 379348 9409 64109951
Sensitivity to weather change 11.34 9.74 73 379299 6641 64112719
Myocardial ischaemia 11.34 9.74 85 379287 23166 64096194
Memory impairment 11.33 9.74 401 378971 85281 64034079
Radiation inflammation 11.28 9.74 10 379362 222 64119138
Unevaluable event 11.28 9.74 219 379153 50270 64069090
Hydrocephalus 11.24 9.74 17 379355 7574 64111786
Myelosuppression 11.21 9.74 88 379284 23742 64095618
Medical device site joint infection 11.17 9.74 10 379362 225 64119135
Drug tolerance decreased 11.16 9.74 75 379297 6923 64112437
Accidental death 11.11 9.74 4 379368 3721 64115639
Intestinal ischaemia 11.11 9.74 33 379339 11516 64107844
Catheter management 11.08 9.74 3 379369 3352 64116008
Haematemesis 11.08 9.74 202 379170 46797 64072563
Neck pain 11.07 9.74 455 378917 61078 64058282
Speech disorder developmental 11.06 9.74 15 379357 544 64118816
Carpal tunnel syndrome 11.05 9.74 142 379230 15686 64103674
Complication of device insertion 11.05 9.74 8 379364 5004 64114356
Pancreatic duct stenosis 11.03 9.74 10 379362 229 64119131
Paranoia 11.01 9.74 54 379318 16298 64103062
Nephrotic syndrome 10.99 9.74 25 379347 9542 64109818
Skin infection 10.97 9.74 136 379236 14901 64104459
Benign ovarian tumour 10.96 9.74 11 379361 287 64119073
Musculoskeletal discomfort 10.93 9.74 145 379227 16132 64103228
Failed induction of labour 10.92 9.74 10 379362 232 64119128
Bundle branch block left 10.91 9.74 27 379345 10007 64109353
Device leakage 10.86 9.74 20 379352 8246 64111114
COVID-19 pneumonia 10.83 9.74 55 379317 16449 64102911
Vascular rupture 10.83 9.74 24 379348 1298 64118062
Prostatic specific antigen increased 10.80 9.74 22 379350 8738 64110622
Hypertriglyceridaemia 10.79 9.74 32 379340 11173 64108187
Hyperhomocysteinaemia 10.79 9.74 13 379359 418 64118942
Vascular insufficiency 10.79 9.74 14 379358 486 64118874
Photophobia 10.78 9.74 152 379220 17141 64102219
Generalised oedema 10.77 9.74 75 379297 20778 64098582
Inflammatory bowel disease 10.74 9.74 54 379318 4484 64114876
Hyperlipidaemia 10.73 9.74 85 379287 22891 64096469
Genital haemorrhage 10.70 9.74 10 379362 5512 64113848
Salivary hypersecretion 10.67 9.74 36 379336 12077 64107283
Oedema 10.67 9.74 437 378935 91498 64027862
Diaphragmatic disorder 10.67 9.74 25 379347 1403 64117957
Acute pulmonary oedema 10.66 9.74 39 379333 12770 64106590
Tooth fracture 10.63 9.74 97 379275 9830 64109530
Cartilage injury 10.62 9.74 24 379348 1315 64118045
Hypoxic-ischaemic encephalopathy 10.60 9.74 16 379356 7136 64112224
Device related infection 10.60 9.74 122 379250 30504 64088856
Ventricular arrhythmia 10.60 9.74 17 379355 7398 64111962
Product administered to patient of inappropriate age 10.60 9.74 7 379365 4594 64114766
Gastroenteritis 10.59 9.74 239 379133 29472 64089888
Hernia pain 10.57 9.74 13 379359 427 64118933
Muscular weakness 10.54 9.74 627 378745 126711 63992649
Mental disorder 10.51 9.74 102 379270 26343 64093017
Lung neoplasm malignant 10.50 9.74 181 379191 21267 64098093
Decreased insulin requirement 10.47 9.74 8 379364 143 64119217
Brain natriuretic peptide increased 10.45 9.74 18 379354 7615 64111745
Intestinal stenosis 10.43 9.74 42 379330 3172 64116188
Impaired work ability 10.40 9.74 136 379236 15083 64104277
Diabetes mellitus inadequate control 10.37 9.74 78 379294 21243 64098117
Mycobacterium tuberculosis complex test positive 10.36 9.74 31 379341 2016 64117344
Hiatus hernia 10.35 9.74 170 379202 19787 64099573
Renal disorder 10.34 9.74 146 379226 35219 64084141
Complication of pregnancy 10.33 9.74 11 379361 308 64119052
Therapeutic product effect incomplete 10.31 9.74 724 378648 102758 64016602
Glomerular filtration rate decreased 10.30 9.74 70 379302 19502 64099858
Type 1 diabetes mellitus 10.29 9.74 11 379361 5694 64113666
Hepatic cytolysis 10.29 9.74 45 379327 14004 64105356
Troponin increased 10.29 9.74 51 379321 15348 64104012
Rash erythematous 10.25 9.74 213 379159 48420 64070940
Personality change 10.25 9.74 22 379350 8571 64110789
Thiopurine methyltransferase decreased 10.22 9.74 11 379361 312 64119048
Blood iron increased 10.17 9.74 24 379348 1353 64118007
Peripheral venous disease 10.15 9.74 68 379304 6270 64113090
Intervertebral disc degeneration 10.15 9.74 120 379252 13000 64106360
Umbilical hernia 10.14 9.74 52 379320 4353 64115007
Aspiration 10.12 9.74 58 379314 16827 64102533
Twin pregnancy 10.10 9.74 18 379354 829 64118531
Respiratory tract infection viral 10.09 9.74 36 379336 2567 64116793
Dementia 10.09 9.74 76 379296 20690 64098670
Lymphadenectomy 10.08 9.74 20 379352 1000 64118360
Haemodialysis 10.06 9.74 59 379313 17018 64102342
Varicose ulceration 10.05 9.74 12 379360 382 64118978
Kidney transplant rejection 10.02 9.74 26 379346 9485 64109875
Crying 10.01 9.74 73 379299 20017 64099343
Vascular device infection 9.98 9.74 13 379359 6167 64113193
Skin texture abnormal 9.98 9.74 12 379360 385 64118975
Haematoma infection 9.94 9.74 23 379349 1280 64118080
Blister infected 9.90 9.74 15 379357 603 64118757
Hepatic siderosis 9.89 9.74 8 379364 156 64119204
Aplasia 9.88 9.74 16 379356 6937 64112423
Clavicle fracture 9.88 9.74 46 379326 3703 64115657
Faecal calprotectin increased 9.84 9.74 45 379327 3595 64115765
Laryngospasm 9.77 9.74 4 379368 3441 64115919
Lethargy 9.77 9.74 339 379033 72255 64047105
Excessive cerumen production 9.77 9.74 14 379358 535 64118825
Lymph gland infection 9.76 9.74 12 379360 394 64118966

FDA Adverse Event Reporting System (Pediatric)

None

Pharmacologic Action:

SourceCodeDescription
CHEBI has role CHEBI:50733 Dietary Supplement

Drug Use (View source of the data)

None




🐶 Veterinary Drug Use

None

🐶 Veterinary products

None

Acid dissociation constants calculated using MoKa v3.0.0

None

Orange Book patent data (new drug applications)

None

Orange Book exclusivity data (new drug applications)

Formulation strengthTrade nameApplicantApplication numberApproval dateTypeDose formRouteExclusivity dateDescription
EQ 0.3MG COPPER/ML;EQ 55MCG BASE/ML;EQ 60MCG SELENIUM/ML;EQ 3MG BASE/ML (1ML) TRALEMENT AM REGENT N209376 July 2, 2020 RX SOLUTION INTRAVENOUS April 30, 2024 NEW CHEMICAL ENTITY
EQ 0.3MG COPPER/ML;EQ 55MCG BASE/ML;EQ 60MCG SELENIUM/ML;EQ 3MG BASE/ML (5ML) TRALEMENT AM REGENT N209376 Dec. 2, 2020 RX SOLUTION INTRAVENOUS April 30, 2024 NEW CHEMICAL ENTITY
EQ 60MCG COPPER/ML;EQ 3MCG BASE/ML;EQ 6MCG SELENIUM/ML;EQ 1000MCG BASE/ML (1ML) MULTRYS AM REGENT N209376 June 30, 2021 RX SOLUTION INTRAVENOUS April 30, 2024 NEW CHEMICAL ENTITY

Bioactivity Summary:

None

External reference:

IDSource
D04854 KEGG_DRUG
4017709 VUID
N0000179176 NUI
4017681 VANDF
4017709 VANDF
CHEBI:86364 CHEBI
CHEMBL1200557 ChEMBL_ID
CHEMBL2103742 ChEMBL_ID
C039798 MESH_SUPPLEMENTAL_RECORD_UI
W00LYS4T26 UNII
24580 PUBCHEM_CID
29268 RXNORM
1544 MMSL
33690 MMSL
5021 MMSL
d00434 MMSL
000858 NDDF
C0065649 UMLSCUI
10034-96-5 SECONDARY_CAS_RN

Pharmaceutical products:

ProductCategoryIngredientsNDCFormQuantityRouteMarketingLabel
Multitrace-4 Neonatal HUMAN PRESCRIPTION DRUG LABEL 4 0517-6202 INJECTION, SOLUTION 77 mg INTRAVENOUS UNAPPROVED DRUG OTHER 14 sections
Manganese Sulfate HUMAN PRESCRIPTION DRUG LABEL 1 0517-6410 INJECTION, SOLUTION 0.10 mg INTRAVENOUS UNAPPROVED DRUG OTHER 13 sections
Multitrace-5 HUMAN PRESCRIPTION DRUG LABEL 5 0517-8201 INJECTION, SOLUTION, CONCENTRATE 1.54 mg INTRAVENOUS UNAPPROVED DRUG OTHER 14 sections
Multitrace-5 HUMAN PRESCRIPTION DRUG LABEL 5 0517-8210 INJECTION, SOLUTION, CONCENTRATE 1.54 mg INTRAVENOUS UNAPPROVED DRUG OTHER 14 sections
Multitrace-5 HUMAN PRESCRIPTION DRUG LABEL 5 0517-8510 INJECTION, SOLUTION 0.31 mg INTRAVENOUS UNAPPROVED DRUG OTHER 14 sections
Multitrace -4 Pediatric HUMAN PRESCRIPTION DRUG LABEL 4 0517-9203 INJECTION, SOLUTION, CONCENTRATE 77 ug INTRAVENOUS UNAPPROVED DRUG OTHER 14 sections
Multrys HUMAN PRESCRIPTION DRUG LABEL 4 0517-9302 INJECTION, SOLUTION 8.22 ug INTRAVENOUS NDA 19 sections
Tralement HUMAN PRESCRIPTION DRUG LABEL 4 0517-9305 INJECTION, SOLUTION 55 ug INTRAVENOUS NDA 22 sections
Trace Elements 4 HUMAN PRESCRIPTION DRUG LABEL 4 0517-9310 INJECTION, SOLUTION 92.30 ug INTRAVENOUS UNAPPROVED DRUG OTHER 14 sections
Se-Tan PLUS HUMAN PRESCRIPTION DRUG LABEL 13 13925-118 CAPSULE, GELATIN COATED 1.30 mg ORAL unapproved drug other 19 sections
Se-Tan PLUS HUMAN PRESCRIPTION DRUG LABEL 13 13925-118 CAPSULE, GELATIN COATED 1.30 mg ORAL unapproved drug other 19 sections
Centratex HUMAN PRESCRIPTION DRUG LABEL 13 23359-100 CAPSULE 1.30 mg ORAL unapproved drug other 13 sections
Concept OB HUMAN PRESCRIPTION DRUG LABEL 15 52747-620 CAPSULE 1.30 mg ORAL unapproved drug other 13 sections
PureVit DualFe Plus HUMAN PRESCRIPTION DRUG LABEL 13 59088-112 CAPSULE 1.30 mg ORAL unapproved drug other 12 sections
Vitrexyl HUMAN PRESCRIPTION DRUG LABEL 17 59088-164 TABLET 2.30 mg ORAL unapproved drug other 11 sections
Vitrexyl plus Iron HUMAN PRESCRIPTION DRUG LABEL 18 59088-165 TABLET 2.30 mg ORAL unapproved drug other 13 sections
Prenatrix HUMAN PRESCRIPTION DRUG LABEL 20 59088-166 TABLET 2.60 mg ORAL unapproved drug other 13 sections
Vitrexate HUMAN PRESCRIPTION DRUG LABEL 17 59088-167 TABLET 2.30 mg ORAL unapproved drug other 11 sections
Vitrexate FE HUMAN PRESCRIPTION DRUG LABEL 18 59088-168 TABLET 2.30 mg ORAL unapproved drug other 13 sections
Prenatryl HUMAN PRESCRIPTION DRUG LABEL 20 59088-169 TABLET 2.60 mg ORAL unapproved drug other 13 sections
Vitranol HUMAN PRESCRIPTION DRUG LABEL 17 59088-171 TABLET 2.30 mg ORAL unapproved drug other 11 sections
Prometa HUMAN PRESCRIPTION DRUG LABEL 20 59088-172 TABLET 2.60 mg ORAL unapproved drug other 13 sections
Vitranol Fe HUMAN PRESCRIPTION DRUG LABEL 18 59088-173 TABLET 2.30 mg ORAL unapproved drug other 13 sections
Venexa HUMAN PRESCRIPTION DRUG LABEL 17 59088-176 TABLET 2.30 mg ORAL unapproved drug other 11 sections
Venexa FE HUMAN PRESCRIPTION DRUG LABEL 18 59088-177 TABLET 2.30 mg ORAL unapproved drug other 13 sections
Pretrate HUMAN PRESCRIPTION DRUG LABEL 20 59088-178 TABLET 2.60 mg ORAL unapproved drug other 13 sections
Zintrexyl-C HUMAN PRESCRIPTION DRUG LABEL 24 59088-180 TABLET 0.75 mg ORAL unapproved drug other 13 sections
Folitin-Z HUMAN PRESCRIPTION DRUG LABEL 24 59088-181 TABLET 0.75 mg ORAL unapproved drug other 13 sections
Ribotin-E HUMAN PRESCRIPTION DRUG LABEL 24 59088-182 TABLET 0.75 mg ORAL unapproved drug other 13 sections
Ventrixyl HUMAN PRESCRIPTION DRUG LABEL 17 59088-186 TABLET 2.30 mg ORAL unapproved drug other 12 sections