manganese sulfate 🐶 Veterinary Use | Indications/Contra | FAERs-F | FAERs-M | Orange Bk | BioActivity |

Stem definitionDrug idCAS RN
4461 7785-87-7

Description:

MoleculeDescription

Synonyms:

  • manganese sulfate
  • Molecular weight: 150.99
  • Formula: MnO4S
  • CLOGP:
  • LIPINSKI: None
  • HAC: None
  • HDO: None
  • TPSA: 80.26
  • ALOGS:
  • ROTB: None

Drug dosage:

None

ADMET properties:

None

Approvals:

DateAgencyCompanyOrphan
None FDA

FDA Adverse Event Reporting System (Female)

MedDRA adverse event termLikelihood ratioLikelihood ratio thresholdPatients taking drug having adverse eventPatients taking drug not having adverse eventPatients not taking drug having adverse eventPatients not taking drug not having adverse event
Pemphigus 1805.11 10.33 4403 521355 179323 62783941
Systemic lupus erythematosus 1705.63 10.33 4670 521088 204248 62759016
Glossodynia 1509.08 10.33 4048 521710 174828 62788436
Hand deformity 1231.82 10.33 3495 522263 155962 62807302
Arthropathy 1144.34 10.33 4401 521357 230391 62732873
Abdominal discomfort 1059.53 10.33 5352 520406 315533 62647731
Alopecia 1050.25 10.33 5537 520221 331999 62631265
Wound 1020.13 10.33 3322 522436 159941 62803323
Completed suicide 958.59 10.33 63 525695 145610 62817654
Rheumatoid arthritis 910.42 10.33 4336 521422 249483 62713781
Maternal exposure during pregnancy 905.29 10.33 3915 521843 216147 62747117
Synovitis 817.90 10.33 3389 522369 183529 62779735
Anti-cyclic citrullinated peptide antibody positive 773.18 10.33 2417 523341 113795 62849469
Pericarditis 767.86 10.33 2617 523141 128962 62834302
Swelling 761.44 10.33 4377 521381 271001 62692263
Discomfort 758.50 10.33 3068 522690 164306 62798958
Toxicity to various agents 754.55 10.33 567 525191 246683 62716581
Contraindicated product administered 731.88 10.33 3651 522107 213997 62749267
Infusion related reaction 700.62 10.33 3936 521822 241585 62721679
Joint swelling 685.10 10.33 4851 520907 322815 62640449
Pain 603.63 10.33 9028 516730 731600 62231664
Death 526.92 10.33 1482 524276 372899 62590365
Duodenal ulcer perforation 487.94 10.33 1711 524047 85498 62877766
Rheumatoid factor positive 478.29 10.33 1663 524095 82743 62880521
Helicobacter infection 474.67 10.33 1768 523990 91017 62872247
Product use issue 461.43 10.33 3267 522491 217253 62746011
Hepatic enzyme increased 425.27 10.33 3001 522757 199327 62763937
Drug interaction 425.25 10.33 780 524978 228351 62734913
Intentional overdose 414.81 10.33 60 525698 74092 62889172
Arthralgia 394.33 10.33 6763 518995 562947 62400317
Drug abuse 378.20 10.33 71 525687 72447 62890817
Psoriatic arthropathy 357.13 10.33 1604 524154 89916 62873348
Musculoskeletal stiffness 344.33 10.33 2662 523096 181956 62781308
Therapeutic product effect decreased 332.15 10.33 2734 523024 190453 62772811
Drug intolerance 318.45 10.33 3930 521828 304731 62658533
Febrile neutropenia 313.08 10.33 311 525447 118138 62845126
Exposure during pregnancy 284.50 10.33 2233 523525 153314 62809950
Suicide attempt 279.17 10.33 79 525679 60839 62902425
Treatment failure 271.51 10.33 2679 523079 196364 62766900
Hip arthroplasty 253.70 10.33 920 524838 46726 62916538
Depressed level of consciousness 252.16 10.33 99 525659 61979 62901285
Knee arthroplasty 247.76 10.33 997 524761 53209 62910055
Acute kidney injury 245.80 10.33 1233 524525 262182 62701082
Cardiac arrest 242.23 10.33 245 525513 92300 62870964
Overdose 238.98 10.33 364 525394 114714 62848550
Hypersensitivity 238.27 10.33 3572 522186 289113 62674151
Malignant neoplasm progression 218.83 10.33 214 525544 81907 62881357
Rheumatic fever 214.94 10.33 815 524943 42296 62920968
Impaired healing 209.34 10.33 1511 524247 101031 62862233
Nasopharyngitis 202.57 10.33 3092 522666 251165 62712099
Disease progression 201.79 10.33 448 525310 122310 62840954
Swollen joint count increased 187.56 10.33 691 525067 35363 62927901
Neutropenia 185.83 10.33 781 524977 174224 62789040
Constipation 182.84 10.33 1102 524656 223841 62739423
Folliculitis 175.29 10.33 1089 524669 69228 62894036
Sedation 172.93 10.33 53 525705 38756 62924508
Blister 172.86 10.33 1739 524019 128075 62835189
Electrocardiogram QT prolonged 171.88 10.33 144 525614 59386 62903878
Muscle injury 169.84 10.33 1023 524735 64322 62898942
Red blood cell sedimentation rate abnormal 168.62 10.33 450 525308 19332 62943932
Hyponatraemia 165.97 10.33 431 525327 111469 62851795
Lactic acidosis 164.03 10.33 56 525702 38231 62925033
Bradycardia 163.48 10.33 220 525538 73007 62890257
Fatigue 158.82 10.33 8922 516836 879106 62084158
Nausea 154.81 10.33 5657 520101 848814 62114450
Sleep disorder due to general medical condition, insomnia type 150.35 10.33 840 524918 51377 62911887
Rash 149.31 10.33 5865 519893 555006 62408258
Hypotension 147.32 10.33 1494 524264 271110 62692154
Cardiac failure 145.91 10.33 326 525432 88816 62874448
Somnolence 145.35 10.33 875 524883 177810 62785454
Sickle cell anaemia with crisis 142.32 10.33 210 525548 5793 62957471
Irritable bowel syndrome 140.69 10.33 1165 524593 81247 62882017
Agitation 134.95 10.33 178 525580 59579 62903685
Drug reaction with eosinophilia and systemic symptoms 134.08 10.33 56 525702 33780 62929484
Hyperhidrosis 133.42 10.33 452 525306 107384 62855880
C-reactive protein abnormal 133.02 10.33 742 525016 45354 62917910
Rhabdomyolysis 132.28 10.33 102 525656 43849 62919415
Diarrhoea 131.40 10.33 4727 521031 710639 62252625
Respiratory arrest 131.02 10.33 53 525705 32592 62930672
Renal failure 130.52 10.33 516 525242 117136 62846128
Lower respiratory tract infection 126.47 10.33 1662 524096 130645 62832619
Drug hypersensitivity 126.14 10.33 1812 523946 308875 62654389
Blood cholesterol increased 120.99 10.33 1251 524507 92781 62870483
Tremor 120.34 10.33 624 525134 131615 62831649
Sopor 119.23 10.33 20 525738 22144 62941120
Asthenia 118.69 10.33 2351 523407 381253 62582011
Intentional self-injury 118.25 10.33 33 525725 25654 62937610
Neoplasm progression 118.21 10.33 78 525680 36350 62926914
Anxiety 117.57 10.33 1192 524566 216349 62746915
Osteoarthritis 113.13 10.33 1248 524510 94095 62869169
Vomiting 111.36 10.33 3660 522098 555957 62407307
Tachycardia 108.94 10.33 555 525203 117601 62845663
Dyspnoea 108.08 10.33 4430 521328 656883 62306381
Liver injury 107.85 10.33 864 524894 59656 62903608
Cardio-respiratory arrest 107.63 10.33 208 525550 59751 62903513
Serotonin syndrome 106.56 10.33 52 525706 28630 62934634
Condition aggravated 106.56 10.33 4205 521553 398012 62565252
Coma 106.46 10.33 234 525524 64130 62899134
Arthritis 105.75 10.33 1444 524314 114477 62848787
Type 2 diabetes mellitus 104.30 10.33 894 524864 62974 62900290
Thrombocytopenia 103.97 10.33 778 524980 150379 62812885
Syncope 102.30 10.33 562 525196 116823 62846441
Pregnancy 100.40 10.33 584 525174 36252 62927012
Cognitive disorder 99.85 10.33 194 525564 55621 62907643
Fibromyalgia 98.79 10.33 1060 524698 79360 62883904
Anaemia 98.51 10.33 1773 523985 291657 62671607
Hypoglycaemia 98.01 10.33 220 525538 59845 62903419
Renal impairment 97.67 10.33 388 525370 87967 62875297
Psoriasis 97.62 10.33 1126 524632 85831 62877433
No adverse event 91.79 10.33 125 525633 41280 62921984
Hepatic failure 91.45 10.33 96 525662 35560 62927704
Metabolic acidosis 90.24 10.33 146 525612 44923 62918341
Intentional product use issue 89.20 10.33 1522 524236 126370 62836894
Peripheral swelling 88.00 10.33 2852 522906 263090 62700174
Live birth 85.89 10.33 430 525328 25200 62938064
Intentional product misuse 85.50 10.33 241 525517 60676 62902588
Ill-defined disorder 84.89 10.33 1043 524715 80712 62882552
Drug resistance 84.56 10.33 42 525716 22891 62940373
Sedation complication 82.59 10.33 9 525749 13813 62949451
Hepatic function abnormal 82.47 10.33 112 525646 37030 62926234
Contusion 82.38 10.33 1721 524037 148323 62814941
Abortion spontaneous 82.04 10.33 670 525088 46525 62916739
Drug dependence 81.38 10.33 51 525707 24432 62938832
Orthostatic hypotension 81.34 10.33 108 525650 36052 62927212
Multiple sclerosis relapse 81.20 10.33 175 525583 48303 62914961
Neuropathy peripheral 81.05 10.33 579 525179 113088 62850176
Hyperglycaemia 80.70 10.33 139 525619 41728 62921536
Joint effusion 80.50 10.33 317 525441 16743 62946521
Respiratory failure 80.06 10.33 504 525254 101354 62861910
Drug ineffective 79.46 10.33 9840 515918 1034925 61928339
Asthma 79.18 10.33 675 525083 126886 62836378
Seizure 78.72 10.33 710 525048 131924 62831340
Multiple organ dysfunction syndrome 78.56 10.33 226 525532 56526 62906738
Drug withdrawal syndrome 78.22 10.33 66 525692 27128 62936136
Macular degeneration 78.01 10.33 53 525705 24323 62938941
Altered state of consciousness 77.91 10.33 57 525701 25173 62938091
Myalgia 77.83 10.33 806 524952 145723 62817541
Blood pressure diastolic abnormal 75.86 10.33 279 525479 14263 62949001
Angioedema 75.57 10.33 179 525579 47786 62915478
Blood pressure systolic abnormal 75.10 10.33 263 525495 13123 62950141
Dizziness 74.57 10.33 2859 522899 427066 62536198
Blood pressure fluctuation 74.39 10.33 646 525112 45671 62917593
Drug ineffective for unapproved indication 73.35 10.33 105 525653 33958 62929306
Hallucination 73.20 10.33 222 525536 54595 62908669
Sinusitis 72.46 10.33 2421 523337 224232 62739032
Blood glucose increased 71.32 10.33 404 525354 83352 62879912
Encephalopathy 71.04 10.33 132 525626 38488 62924776
Red blood cell sedimentation rate increased 70.93 10.33 614 525144 43368 62919896
Hypoxia 69.66 10.33 257 525501 59535 62903729
Creatinine renal clearance decreased 69.60 10.33 24 525734 16284 62946980
Balance disorder 69.33 10.33 412 525346 84010 62879254
Product quality issue 69.19 10.33 119 525639 35746 62927518
Hepatocellular injury 68.79 10.33 75 525683 27306 62935958
Device expulsion 68.17 10.33 115 525643 34807 62928457
Disability assessment scale score increased 68.02 10.33 107 525651 3126 62960138
Foot deformity 67.90 10.33 429 525329 27424 62935840
Hyperkalaemia 67.83 10.33 226 525532 53977 62909287
Cytomegalovirus infection 67.79 10.33 45 525713 20907 62942357
Palmar-plantar erythrodysaesthesia syndrome 67.25 10.33 55 525703 22960 62940304
Chest discomfort 66.87 10.33 585 525173 109384 62853880
Metastases to bone 66.86 10.33 46 525712 20973 62942291
Anaphylactic reaction 65.83 10.33 302 525456 65798 62897466
Dehydration 65.78 10.33 1024 524734 172330 62790934
Vision blurred 65.65 10.33 468 525290 91456 62871808
Neutrophil count decreased 65.35 10.33 243 525515 56163 62907101
Cholestasis 65.10 10.33 89 525669 29345 62933919
Cardiac failure congestive 64.36 10.33 474 525284 91959 62871305
Basal cell carcinoma 63.27 10.33 423 525335 27568 62935696
Cytokine release syndrome 62.96 10.33 20 525738 14294 62948970
Leukopenia 62.51 10.33 379 525379 76911 62886353
Myocardial infarction 62.25 10.33 528 525230 99365 62863899
Ejection fraction decreased 62.05 10.33 56 525702 22276 62940988
Product use in unapproved indication 60.04 10.33 1082 524676 177998 62785266
Stomatitis 59.68 10.33 1538 524220 137187 62826077
Feeling abnormal 59.57 10.33 867 524891 147525 62815739
Osteonecrosis of jaw 59.48 10.33 126 525632 34997 62928267
Shock 59.24 10.33 64 525694 23399 62939865
Grip strength decreased 59.21 10.33 351 525407 21936 62941328
Blood pressure systolic increased 58.78 10.33 626 525132 46771 62916493
Poisoning 58.75 10.33 20 525738 13680 62949584
Pulmonary fibrosis 58.69 10.33 545 525213 39264 62924000
Gamma-glutamyltransferase increased 58.54 10.33 121 525637 33910 62929354
Weight increased 58.44 10.33 2680 523078 258112 62705152
Hypokalaemia 58.01 10.33 564 525194 103240 62860024
Anaphylactic shock 57.98 10.33 66 525692 23567 62939697
COVID-19 57.67 10.33 628 525130 112475 62850789
Osteoporosis 57.58 10.33 727 525031 56611 62906653
Infection 57.55 10.33 2383 523375 226790 62736474
Diabetic ketoacidosis 57.47 10.33 51 525707 20454 62942810
Injection site erythema 57.30 10.33 988 524770 82186 62881078
Insomnia 56.95 10.33 1352 524406 213900 62749364
Blood creatine phosphokinase increased 56.86 10.33 103 525655 30327 62932937
Restlessness 56.57 10.33 98 525660 29355 62933909
Suicidal ideation 56.50 10.33 295 525463 62126 62901138
Juvenile idiopathic arthritis 56.49 10.33 100 525658 3226 62960038
Loss of consciousness 55.87 10.33 667 525091 117454 62845810
Bone erosion 55.71 10.33 292 525466 17425 62945839
Respiratory depression 55.47 10.33 22 525736 13693 62949571
Disturbance in attention 55.14 10.33 149 525609 38040 62925224
Blood calcium decreased 54.55 10.33 84 525674 26367 62936897
Drug level increased 54.16 10.33 65 525693 22671 62940593
White blood cell count decreased 54.01 10.33 818 524940 138286 62824978
Mydriasis 53.85 10.33 16 525742 11940 62951324
Joint range of motion decreased 53.49 10.33 455 525303 31973 62931291
Disorientation 52.51 10.33 160 525598 39292 62923972
Joint laxity 52.47 10.33 82 525676 2382 62960882
Ventricular tachycardia 52.13 10.33 53 525705 19926 62943338
Inflammation 51.97 10.33 964 524794 81309 62881955
Wrong technique in product usage process 51.83 10.33 303 525455 62037 62901227
Disseminated intravascular coagulation 51.48 10.33 49 525709 19002 62944262
Blood pressure decreased 51.46 10.33 321 525437 64701 62898563
Dysphagia 51.33 10.33 477 525281 88108 62875156
Loss of personal independence in daily activities 50.17 10.33 1106 524652 96184 62867080
Joint destruction 50.06 10.33 139 525619 6113 62957151
Metastases to liver 49.78 10.33 74 525684 23565 62939699
Drug tolerance decreased 49.56 10.33 280 525478 17193 62946071
Extrapyramidal disorder 49.47 10.33 24 525734 13260 62950004
C-reactive protein increased 49.27 10.33 1078 524680 93629 62869635
Platelet count decreased 49.24 10.33 671 525087 115451 62847813
Mental status changes 48.94 10.33 166 525592 39433 62923831
Acute hepatic failure 48.52 10.33 48 525710 18279 62944985
Torsade de pointes 48.40 10.33 25 525733 13326 62949938
Caesarean section 48.35 10.33 273 525485 16759 62946505
Injection site reaction 46.96 10.33 713 525045 57811 62905453
Neurotoxicity 46.73 10.33 43 525715 16947 62946317
Cerebral haemorrhage 46.58 10.33 117 525641 30612 62932652
Speech disorder 46.43 10.33 176 525582 40453 62922811
Ascites 46.18 10.33 177 525581 40551 62922713
Abnormal behaviour 46.17 10.33 66 525692 21360 62941904
Dysarthria 45.65 10.33 190 525568 42521 62920743
Palpitations 45.55 10.33 658 525100 112112 62851152
Respiratory disorder 45.51 10.33 168 525590 38914 62924350
Emotional distress 45.50 10.33 129 525629 32420 62930844
Blood alkaline phosphatase increased 45.39 10.33 192 525566 42775 62920489
Posterior reversible encephalopathy syndrome 45.27 10.33 46 525712 17299 62945965
Muscle spasticity 45.15 10.33 69 525689 21725 62941539
Polyarthritis 45.05 10.33 185 525573 9961 62953303
Injection site pruritus 44.43 10.33 570 525188 44546 62918718
Hypothermia 44.17 10.33 29 525729 13552 62949712
Inappropriate antidiuretic hormone secretion 43.89 10.33 38 525720 15424 62947840
Pulmonary embolism 43.65 10.33 691 525067 115993 62847271
Urticaria 43.12 10.33 1044 524714 164758 62798506
Unresponsive to stimuli 43.00 10.33 140 525618 33676 62929588
Sepsis 42.94 10.33 953 524805 152170 62811094
Accidental exposure to product 42.59 10.33 103 525655 27302 62935962
Disability 42.52 10.33 279 525479 18068 62945196
Blood creatinine increased 42.32 10.33 494 525264 87350 62875914
Blood pressure diastolic decreased 42.00 10.33 327 525431 22379 62940885
Chronic kidney disease 41.95 10.33 213 525545 45185 62918079
Schizophrenia 41.86 10.33 15 525743 9937 62953327
Vertigo 41.73 10.33 307 525451 59580 62903684
Akathisia 41.63 10.33 12 525746 9134 62954130
Fluid retention 41.10 10.33 307 525451 59379 62903885
Flushing 41.09 10.33 410 525348 74677 62888587
Blood bilirubin increased 41.09 10.33 163 525595 36977 62926287
Rheumatoid nodule 41.06 10.33 263 525495 16892 62946372
Myelosuppression 41.00 10.33 84 525674 23619 62939645
Device difficult to use 40.71 10.33 28 525730 12768 62950496
Depression 40.59 10.33 1278 524480 195214 62768050
Gestational diabetes 40.41 10.33 157 525601 8239 62955025
Neuroleptic malignant syndrome 40.23 10.33 25 525733 12031 62951233
Polyneuropathy 40.04 10.33 37 525721 14552 62948712
Withdrawal syndrome 39.82 10.33 65 525693 19932 62943332
Neck deformity 38.94 10.33 66 525692 2055 62961209
Psychotic disorder 38.89 10.33 98 525660 25614 62937650
Hepatotoxicity 38.83 10.33 166 525592 36875 62926389
Parkinsonism 38.66 10.33 19 525739 10420 62952844
Foetal exposure during pregnancy 38.63 10.33 420 525338 31542 62931722
Premature labour 38.57 10.33 205 525553 12299 62950965
Dyskinesia 38.30 10.33 136 525622 31866 62931398
Tuberculosis 38.20 10.33 189 525569 11022 62952242
Respiratory distress 38.20 10.33 148 525610 33803 62929461
Hypomania 38.13 10.33 4 525754 6326 62956938
Disease recurrence 37.79 10.33 113 525645 27917 62935347
Bone pain 37.65 10.33 281 525477 54360 62908904
Arrhythmia 37.53 10.33 175 525583 37965 62925299
Eosinophilia 37.40 10.33 83 525675 22673 62940591
Toxic skin eruption 37.39 10.33 31 525727 12854 62950410
Hospitalisation 37.38 10.33 488 525270 84593 62878671
Diabetes mellitus inadequate control 37.37 10.33 42 525716 15084 62948180
Multiple fractures 37.37 10.33 156 525602 8462 62954802
Haemorrhage 37.35 10.33 324 525434 60698 62902566
Joint stiffness 37.11 10.33 519 525239 41350 62921914
Adverse event 37.07 10.33 775 524983 66784 62896480
Acute generalised exanthematous pustulosis 37.05 10.33 23 525735 11076 62952188
Stress cardiomyopathy 36.86 10.33 16 525742 9434 62953830
Dystonia 36.81 10.33 36 525722 13783 62949481
Accidental overdose 36.70 10.33 87 525671 23222 62940042
Thrombotic microangiopathy 36.50 10.33 21 525737 10540 62952724
Ventricular fibrillation 36.40 10.33 27 525731 11840 62951424
Pain in jaw 36.38 10.33 211 525547 43285 62919979
Depressed mood 36.33 10.33 190 525568 40001 62923263
Metastases to central nervous system 36.24 10.33 33 525725 13072 62950192
Cerebrovascular accident 35.77 10.33 654 525104 107370 62855894
Product administration error 35.74 10.33 83 525675 22314 62940950
Agranulocytosis 35.58 10.33 99 525659 25035 62938229
Second primary malignancy 35.18 10.33 11 525747 7942 62955322
Exposure to toxic agent 35.06 10.33 3 525755 5584 62957680
Haematotoxicity 34.83 10.33 17 525741 9359 62953905
Face oedema 34.65 10.33 72 525686 20140 62943124
Brain oedema 34.44 10.33 40 525718 14155 62949109
Pancreatitis acute 34.17 10.33 113 525645 27053 62936211
Decreased appetite 33.84 10.33 1716 524042 249336 62713928
Hypomagnesaemia 33.81 10.33 123 525635 28614 62934650
Colitis 33.70 10.33 249 525509 48279 62914985
Gastrointestinal disorder 33.67 10.33 1368 524390 129871 62833393
Bronchospasm 33.64 10.33 57 525701 17223 62946041
Nodule 33.62 10.33 293 525465 20733 62942531
Hemiparesis 33.49 10.33 91 525667 23191 62940073
Gastrointestinal haemorrhage 33.36 10.33 472 525286 80704 62882560
Pulmonary oedema 33.30 10.33 292 525466 54581 62908683
Dysgeusia 33.24 10.33 238 525520 46472 62916792
Mobility decreased 33.20 10.33 1272 524486 119887 62843377
Maternal drugs affecting foetus 32.94 10.33 107 525651 5135 62958129
Alanine aminotransferase increased 32.88 10.33 633 525125 103137 62860127
Miosis 32.83 10.33 10 525748 7343 62955921
Aspartate aminotransferase increased 32.63 10.33 538 525220 89739 62873525
Transplant rejection 32.45 10.33 25 525733 10755 62952509
Musculoskeletal pain 32.39 10.33 997 524761 91280 62871984
Tumour lysis syndrome 32.34 10.33 17 525741 8973 62954291
Laryngitis 32.30 10.33 246 525512 16721 62946543
Tenderness 32.23 10.33 307 525451 22271 62940993
Coagulopathy 32.09 10.33 77 525681 20467 62942797
Pyrexia 32.03 10.33 3409 522349 467069 62496195
General physical health deterioration 31.55 10.33 2002 523756 199400 62763864
Atrial fibrillation 31.54 10.33 730 525028 115906 62847358
Obstructive airways disorder 31.22 10.33 79 525679 20620 62942644
Joint dislocation 31.12 10.33 264 525494 18536 62944728
Dyspnoea exertional 31.06 10.33 334 525424 59968 62903296
Maternal exposure before pregnancy 30.94 10.33 135 525623 7468 62955796
Heart rate decreased 30.94 10.33 540 525218 45020 62918244
Mania 30.93 10.33 34 525724 12333 62950931
Ventricular septal defect 30.87 10.33 93 525665 4285 62958979
Panic attack 30.85 10.33 89 525669 22242 62941022
Irritability 30.85 10.33 146 525612 31548 62931716
Status epilepticus 30.82 10.33 49 525709 15184 62948080
Jaundice 30.72 10.33 131 525627 29120 62934144
Enthesopathy 30.63 10.33 147 525611 8467 62954797
Atrioventricular block complete 30.59 10.33 15 525743 8236 62955028
Injection site swelling 30.59 10.33 559 525199 47013 62916251
Pulmonary arterial hypertension 30.45 10.33 91 525667 22486 62940778
Haemophagocytic lymphohistiocytosis 30.31 10.33 26 525732 10601 62952663
Forced expiratory volume decreased 30.29 10.33 3 525755 4965 62958299
Lymphocyte count decreased 30.26 10.33 138 525620 30119 62933145
Hyperlipidaemia 30.06 10.33 74 525684 19497 62943767
Nightmare 29.94 10.33 72 525686 19122 62944142
Melaena 29.48 10.33 140 525618 30225 62933039
Myoclonus 29.39 10.33 54 525704 15814 62947450
Device use error 29.27 10.33 6 525752 5755 62957509
Ankylosing spondylitis 29.15 10.33 167 525591 10307 62952957
International normalised ratio increased 29.08 10.33 245 525513 46180 62917084
Substance abuse 29.05 10.33 3 525755 4804 62958460
Proteinuria 28.93 10.33 73 525685 19072 62944192
Pleural effusion 28.80 10.33 571 525187 92639 62870625
Wheelchair user 28.67 10.33 116 525642 6203 62957061
Localised infection 28.62 10.33 379 525379 29831 62933433
Sinus tachycardia 28.47 10.33 104 525654 24164 62939100
Prescribed underdose 28.35 10.33 373 525385 29316 62933948
Asphyxia 28.34 10.33 8 525750 6173 62957091
Ischaemic stroke 28.29 10.33 67 525691 17890 62945374
Chronic sinusitis 28.23 10.33 39 525719 12804 62950460
Aphasia 28.18 10.33 159 525599 32841 62930423
Lupus-like syndrome 28.14 10.33 220 525538 15075 62948189
Blood pressure diastolic increased 28.12 10.33 160 525598 9850 62953414
Cytopenia 27.81 10.33 33 525725 11568 62951696
Off label use 27.71 10.33 5041 520717 669421 62293843
Device related infection 27.60 10.33 100 525658 23292 62939972
Pain in extremity 27.56 10.33 3142 522616 328344 62634920
Aggression 27.37 10.33 101 525657 23397 62939867
Stevens-Johnson syndrome 27.28 10.33 110 525648 24840 62938424
Limb deformity 27.27 10.33 84 525674 3918 62959346
Procedural pain 26.93 10.33 90 525668 21479 62941785
Latent tuberculosis 26.82 10.33 64 525694 2563 62960701
Metastases to lung 26.76 10.33 40 525718 12710 62950554
Small for dates baby 26.75 10.33 80 525678 3671 62959593
Angina pectoris 26.74 10.33 143 525615 29935 62933329
Cardiogenic shock 26.62 10.33 69 525689 17863 62945401
Back pain 26.58 10.33 1856 523902 262289 62700975
Facet joint syndrome 26.57 10.33 182 525576 11956 62951308
Rash maculo-papular 26.53 10.33 155 525603 31741 62931523
Peripheral venous disease 26.50 10.33 219 525539 15258 62948006
Erythema multiforme 26.50 10.33 27 525731 10142 62953122
Obesity 26.43 10.33 371 525387 29581 62933683
Rhinitis allergic 26.40 10.33 35 525723 11692 62951572
Cerebral infarction 26.34 10.33 105 525653 23788 62939476
Muscle twitching 26.00 10.33 80 525678 19588 62943676
Chest pain 25.94 10.33 1493 524265 214466 62748798
Urinary retention 25.87 10.33 146 525612 30155 62933109
Tenosynovitis 25.69 10.33 199 525559 13596 62949668
Graft versus host disease 25.52 10.33 12 525746 6751 62956513
Haemorrhage intracranial 25.45 10.33 45 525713 13374 62949890
Bradyphrenia 25.41 10.33 13 525745 6967 62956297
Acute respiratory failure 25.38 10.33 174 525584 34311 62928953
Premature rupture of membranes 25.38 10.33 95 525663 4898 62958366
Injection site pain 25.28 10.33 1316 524442 128484 62834780
Malignant mediastinal neoplasm 25.24 10.33 44 525714 1402 62961862
Product dose omission issue 25.15 10.33 1637 524121 232676 62730588
Dry skin 25.09 10.33 326 525432 56561 62906703
Paralysis 25.00 10.33 27 525731 9873 62953391
Haematoma 24.98 10.33 177 525581 34643 62928621
Acute myeloid leukaemia 24.68 10.33 67 525691 17080 62946184
Tachypnoea 24.61 10.33 68 525690 17234 62946030
Sleep apnoea syndrome 24.53 10.33 141 525617 28992 62934272
Temperature regulation disorder 24.53 10.33 10 525748 6122 62957142
Pre-eclampsia 24.36 10.33 144 525614 8989 62954275
Tenosynovitis stenosans 24.23 10.33 72 525686 3292 62959972
Deep vein thrombosis 24.21 10.33 519 525239 83281 62879983
Immune reconstitution inflammatory syndrome 24.21 10.33 10 525748 6074 62957190
Muscle spasms 24.07 10.33 1052 524706 155098 62808166
Paradoxical drug reaction 24.07 10.33 3 525755 4149 62959115
Injection site bruising 24.05 10.33 484 525274 41426 62921838
Personality disorder 24.03 10.33 9 525749 5802 62957462
Tardive dyskinesia 24.00 10.33 21 525737 8481 62954783
Lethargy 23.96 10.33 323 525435 55684 62907580
Fear 23.92 10.33 60 525698 15706 62947558
Nasal polyps 23.92 10.33 10 525748 6029 62957235
Acute graft versus host disease 23.81 10.33 4 525754 4424 62958840
Abdominal pain 23.77 10.33 2099 523659 291357 62671907
Retinitis 23.69 10.33 108 525650 6088 62957176
Haemoptysis 23.67 10.33 140 525618 28586 62934678
Dislocation of vertebra 23.59 10.33 137 525621 8498 62954766
Bronchopulmonary aspergillosis 23.58 10.33 22 525736 8613 62954651
Clostridium difficile colitis 23.57 10.33 89 525669 20480 62942784
Red blood cell sedimentation rate 23.55 10.33 91 525667 4763 62958501
Diabetes mellitus 23.46 10.33 323 525435 55487 62907777
Hallucination, auditory 23.43 10.33 44 525714 12780 62950484
Lip dry 23.41 10.33 213 525545 15257 62948007
Malaise 23.30 10.33 3053 522705 412901 62550363
Muscle rigidity 23.26 10.33 37 525721 11463 62951801
Synovial cyst 23.18 10.33 157 525601 10276 62952988
Smear cervix abnormal 23.10 10.33 65 525693 2881 62960383
Neck mass 23.06 10.33 74 525684 3529 62959735
Complication of device removal 22.94 10.33 7 525751 5135 62958129
Femur fracture 22.90 10.33 479 525279 41277 62921987
Rash erythematous 22.89 10.33 233 525525 42277 62920987
Acidosis 22.85 10.33 36 525722 11197 62952067
Purpura 22.68 10.33 37 525721 11348 62951916
Wound infection 22.58 10.33 274 525484 21136 62942128
Dysmorphism 22.44 10.33 55 525703 2241 62961023
Maternal exposure timing unspecified 22.41 10.33 117 525641 6970 62956294
Skin ulcer 22.39 10.33 490 525268 42555 62920709
Skin papilloma 22.38 10.33 91 525667 4878 62958386
Anti-cyclic citrullinated peptide antibody 22.37 10.33 113 525645 6645 62956619
Delirium 22.16 10.33 290 525468 50251 62913013
Anuria 22.12 10.33 44 525714 12507 62950757
Skin exfoliation 22.09 10.33 239 525519 42863 62920401
Myocarditis 22.06 10.33 32 525726 10293 62952971
Febrile bone marrow aplasia 22.04 10.33 17 525741 7308 62955956
Breast cancer stage I 22.01 10.33 15 525743 6874 62956390
Gastroenteritis viral 21.90 10.33 296 525462 23404 62939860
Crying 21.86 10.33 109 525649 23234 62940030
Prescribed overdose 21.84 10.33 401 525357 33752 62929512
Malignant melanoma 21.81 10.33 165 525593 11191 62952073
Rotator cuff repair 21.80 10.33 52 525706 2082 62961182
Leukocytosis 21.58 10.33 126 525632 25809 62937455
Affective disorder 21.56 10.33 12 525746 6134 62957130
Mental disorder 21.53 10.33 126 525632 25793 62937471
Placental disorder 21.51 10.33 42 525716 1462 62961802
Pulmonary hypertension 21.45 10.33 200 525558 36923 62926341
Bone marrow failure 21.45 10.33 148 525610 29142 62934122
Multiple-drug resistance 21.40 10.33 8 525750 5162 62958102
Synovial fluid analysis 21.40 10.33 56 525702 2377 62960887
Glycosylated haemoglobin increased 21.39 10.33 44 525714 12354 62950910
Infusion site pain 21.33 10.33 70 525688 16799 62946465
Memory impairment 21.29 10.33 679 525079 103579 62859685
Injection site rash 21.29 10.33 244 525514 18565 62944699
Lip swelling 21.27 10.33 160 525598 30903 62932361
Infective pulmonary exacerbation of cystic fibrosis 21.22 10.33 25 525733 8792 62954472
Sexual dysfunction 21.21 10.33 5 525753 4354 62958910
Hallucination, visual 21.15 10.33 85 525673 19213 62944051
Labelled drug-drug interaction medication error 21.11 10.33 50 525708 13349 62949915
Body height below normal 21.02 10.33 52 525706 2131 62961133
Complication of device insertion 20.97 10.33 19 525739 7545 62955719
Psychomotor hyperactivity 20.92 10.33 35 525723 10628 62952636
Dermatitis atopic 20.91 10.33 30 525728 9694 62953570
Therapeutic response decreased 20.86 10.33 662 525096 60863 62902401
Sinus bradycardia 20.83 10.33 57 525701 14494 62948770
Hypothyroidism 20.81 10.33 239 525519 42393 62920871
Circulatory collapse 20.80 10.33 102 525656 21836 62941428
Abdominal distension 20.72 10.33 552 525206 86063 62877201
Adjustment disorder with depressed mood 20.59 10.33 150 525608 10054 62953210
Nervousness 20.54 10.33 161 525597 30818 62932446
Rebound effect 20.49 10.33 6 525752 4520 62958744
Developmental hip dysplasia 20.46 10.33 39 525719 1333 62961931
Pathogen resistance 20.35 10.33 14 525744 6384 62956880
Swollen tongue 20.32 10.33 187 525571 34613 62928651
Cardiomyopathy 20.20 10.33 76 525682 17508 62945756
Body temperature decreased 20.12 10.33 257 525501 20062 62943202
Deep vein thrombosis postoperative 20.08 10.33 162 525596 11207 62952057
Toxic epidermal necrolysis 20.07 10.33 125 525633 25209 62938055
Pseudomonas infection 20.03 10.33 39 525719 11174 62952090
Hyperprolactinaemia 19.94 10.33 4 525754 3896 62959368
Cough 19.90 10.33 2121 523637 290622 62672642
Arthritis infective 19.84 10.33 106 525652 6372 62956892
Anhedonia 19.75 10.33 38 525720 10936 62952328
Loose body in joint 19.73 10.33 37 525721 1249 62962015
Pemphigoid 19.71 10.33 19 525739 7325 62955939
Genital haemorrhage 19.65 10.33 19 525739 7313 62955951
Schizoaffective disorder 19.64 10.33 3 525755 3559 62959705
Bradypnoea 19.55 10.33 3 525755 3547 62959717
Pancreatitis 19.53 10.33 287 525471 48768 62914496
Ketoacidosis 19.46 10.33 6 525752 4372 62958892
Aspergillus infection 19.42 10.33 23 525735 8070 62955194
Coronary artery disease 19.33 10.33 173 525585 32204 62931060
Acute respiratory distress syndrome 19.23 10.33 115 525643 23419 62939845
Cardiotoxicity 19.18 10.33 25 525733 8413 62954851
Product prescribing error 19.17 10.33 133 525625 26156 62937108
Paraesthesia oral 19.15 10.33 88 525670 19168 62944096
Atrioventricular block 19.15 10.33 21 525737 7626 62955638
Synovial disorder 18.94 10.33 48 525710 1997 62961267
Cyanosis 18.94 10.33 74 525684 16861 62946403
Spinal stenosis 18.91 10.33 198 525560 14727 62948537
Hemiplegia 18.85 10.33 30 525728 9293 62953971
Hepatitis acute 18.77 10.33 29 525729 9091 62954173
Pericardial effusion 18.66 10.33 159 525599 29899 62933365
Foetal anticonvulsant syndrome 18.61 10.33 24 525734 581 62962683
Exostosis 18.58 10.33 228 525530 17634 62945630
Rheumatoid lung 18.56 10.33 72 525686 3776 62959488
Hyperthyroidism 18.48 10.33 61 525697 14612 62948652
Subdural haematoma 18.43 10.33 59 525699 14269 62948995
Acute chest syndrome 18.43 10.33 28 525730 793 62962471
Bursitis 18.43 10.33 419 525339 36622 62926642
Vascular device infection 18.40 10.33 20 525738 7292 62955972
Fall 18.33 10.33 2911 522847 389423 62573841
Clear cell renal cell carcinoma 18.31 10.33 39 525719 1446 62961818
Atrial septal defect 18.26 10.33 109 525649 6829 62956435
Antinuclear antibody positive 18.15 10.33 121 525637 7878 62955386
Lymphoedema 18.12 10.33 44 525714 11648 62951616
Paranoia 18.06 10.33 44 525714 11635 62951629
Cardiac failure acute 18.00 10.33 32 525726 9491 62953773
Blood potassium decreased 17.75 10.33 243 525515 41783 62921481
Hypophosphataemia 17.71 10.33 43 525715 11383 62951881
Eating disorder 17.69 10.33 89 525669 18927 62944337
Pulmonary congestion 17.68 10.33 79 525679 17339 62945925
Renal disorder 17.64 10.33 181 525577 32793 62930471
Headache 17.62 10.33 4822 520936 628419 62334845
Hallucinations, mixed 17.57 10.33 9 525749 4820 62958444
Lymphopenia 17.50 10.33 85 525673 18242 62945022
Aspiration 17.49 10.33 40 525718 10811 62952453
Tubulointerstitial nephritis 17.48 10.33 95 525663 19808 62943456
Product administered to patient of inappropriate age 17.47 10.33 3 525755 3265 62959999
Chills 17.44 10.33 764 524994 112614 62850650
Hepatic cytolysis 17.44 10.33 67 525691 15340 62947924
Therapy partial responder 17.41 10.33 39 525719 10619 62952645
Graft versus host disease in gastrointestinal tract 17.27 10.33 3 525755 3238 62960026
Delusion 17.26 10.33 47 525711 11970 62951294
Skin cancer 17.26 10.33 158 525600 11337 62951927
Shock haemorrhagic 17.17 10.33 35 525723 9860 62953404
Erythema 17.16 10.33 1238 524520 174513 62788751
Epstein-Barr virus infection 17.15 10.33 25 525733 8025 62955239
Systemic inflammatory response syndrome 16.97 10.33 13 525745 5608 62957656
Hypophagia 16.97 10.33 171 525587 31088 62932176
Acute myocardial infarction 16.91 10.33 177 525581 31947 62931317
Hypervolaemia 16.88 10.33 152 525606 28261 62935003
Product adhesion issue 16.86 10.33 9 525749 4710 62958554
Blood glucose decreased 16.80 10.33 103 525655 20849 62942415
Antibody test positive 16.78 10.33 55 525703 2652 62960612
Paraesthesia 16.76 10.33 1097 524661 155869 62807395
Acute pulmonary oedema 16.73 10.33 26 525732 8132 62955132
Incorrect product administration duration 16.70 10.33 45 525713 11501 62951763
Human antichimeric antibody positive 16.69 10.33 41 525717 1673 62961591
Ileus 16.69 10.33 64 525694 14661 62948603
Urinary incontinence 16.61 10.33 177 525581 31837 62931427
Toxic encephalopathy 16.55 10.33 18 525740 6561 62956703
Tinnitus 16.52 10.33 202 525556 35426 62927838
Generalised oedema 16.51 10.33 71 525687 15747 62947517
Congenital arterial malformation 16.51 10.33 17 525741 320 62962944
Hepatitis B reactivation 16.50 10.33 3 525755 3134 62960130
Injury 16.42 10.33 753 525005 72494 62890770
Transplant dysfunction 16.40 10.33 10 525748 4862 62958402
Jaundice cholestatic 16.34 10.33 22 525736 7302 62955962
Muscular weakness 16.33 10.33 837 524921 121516 62841748
Feeling hot 16.30 10.33 306 525452 50048 62913216
Eosinophil count increased 16.26 10.33 42 525716 10886 62952378
Sensitisation 16.25 10.33 4 525754 3382 62959882
Colitis microscopic 16.23 10.33 33 525725 9306 62953958
Multiple drug therapy 16.20 10.33 5 525753 3641 62959623
Neutropenic colitis 16.20 10.33 3 525755 3092 62960172
Salivary hypersecretion 16.14 10.33 24 525734 7642 62955622
Complication associated with device 16.06 10.33 79 525679 16899 62946365
Scleritis 16.06 10.33 76 525682 4352 62958912
Hepatitis cholestatic 16.03 10.33 20 525738 6858 62956406
Klebsiella infection 16.00 10.33 29 525729 8537 62954727
Oliguria 15.96 10.33 32 525726 9069 62954195
Renal tubular necrosis 15.93 10.33 48 525710 11830 62951434
Polyuria 15.88 10.33 29 525729 8513 62954751
Renal injury 15.86 10.33 34 525724 9405 62953859
Polyhydramnios 15.78 10.33 48 525710 2223 62961041
Body temperature increased 15.72 10.33 215 525543 36977 62926287
Laryngospasm 15.71 10.33 3 525755 3025 62960239
Treatment noncompliance 15.69 10.33 216 525542 37109 62926155
Lupus vulgaris 15.66 10.33 94 525664 5900 62957364
Bradykinesia 15.66 10.33 12 525746 5176 62958088
Hypertransaminasaemia 15.63 10.33 19 525739 6590 62956674
Mucosal inflammation 15.56 10.33 284 525474 46644 62916620
Fear of injection 15.44 10.33 107 525651 7057 62956207
Blood parathyroid hormone decreased 15.43 10.33 136 525622 9655 62953609
Dysuria 15.38 10.33 192 525566 33546 62929718
Tendonitis 15.36 10.33 238 525520 19377 62943887
Pulmonary tuberculosis 15.28 10.33 76 525682 4441 62958823
Cholecystitis chronic 15.28 10.33 40 525718 10321 62952943
Stillbirth 15.25 10.33 102 525656 6648 62956616
Respiratory acidosis 15.16 10.33 20 525738 6695 62956569
Right ventricular failure 15.12 10.33 82 525676 17106 62946158
Presyncope 15.08 10.33 152 525606 27633 62935631
Peripheral sensory neuropathy 15.04 10.33 24 525734 7427 62955837
Haematemesis 15.04 10.33 170 525588 30242 62933022
Cushingoid 15.03 10.33 121 525637 8364 62954900
Acute coronary syndrome 15.00 10.33 39 525719 10087 62953177
Affect lability 15.00 10.33 45 525713 11106 62952158
Subarachnoid haemorrhage 14.98 10.33 64 525694 14219 62949045
Product preparation error 14.96 10.33 17 525741 6075 62957189
Bundle branch block left 14.96 10.33 22 525736 7037 62956227
Rectal haemorrhage 14.94 10.33 301 525457 48729 62914535
Hypernatraemia 14.90 10.33 25 525733 7584 62955680
Bone lesion 14.89 10.33 16 525742 5865 62957399
Dermatitis exfoliative 14.80 10.33 14 525744 5445 62957819
Granuloma skin 14.78 10.33 120 525638 8317 62954947
Cytomegalovirus viraemia 14.72 10.33 15 525743 5634 62957630
Proctitis 14.69 10.33 14 525744 5427 62957837
Breast cancer female 14.69 10.33 60 525698 13499 62949765
Breast feeding 14.68 10.33 26 525732 839 62962425
Pallor 14.68 10.33 172 525586 30396 62932868
Multiple sclerosis 14.65 10.33 130 525628 24242 62939022
Device breakage 14.52 10.33 48 525710 11494 62951770
Pulseless electrical activity 14.46 10.33 25 525733 7496 62955768
Myopathy 14.46 10.33 46 525712 11145 62952119
Sleep disorder due to a general medical condition 14.45 10.33 52 525706 12136 62951128
Multiple allergies 14.38 10.33 62 525696 13740 62949524
Postoperative wound infection 14.35 10.33 146 525612 10779 62952485
Epilepsy 14.30 10.33 149 525609 26916 62936348
Middle insomnia 14.29 10.33 55 525703 12588 62950676
Hyperuricaemia 14.29 10.33 14 525744 5356 62957908
Hypocalcaemia 14.26 10.33 181 525577 31532 62931732
Ear infection 14.25 10.33 416 525342 37797 62925467
Dementia 14.24 10.33 94 525664 18700 62944564
Crohn's disease 14.11 10.33 79 525679 4834 62958430
Transaminases increased 14.11 10.33 179 525579 31188 62932076
Tumour marker increased 14.05 10.33 12 525746 4903 62958361
Carotid artery thrombosis 14.01 10.33 3 525755 2791 62960473
Oedema peripheral 13.96 10.33 1365 524393 188146 62775118
Fracture delayed union 13.94 10.33 48 525710 2374 62960890
Atrial tachycardia 13.86 10.33 9 525749 4231 62959033
Illness 13.83 10.33 305 525453 48754 62914510
Cardiac disorder 13.74 10.33 318 525440 50498 62912766
Injection site warmth 13.72 10.33 189 525569 15006 62948258
Mood altered 13.72 10.33 69 525689 14674 62948590
Coordination abnormal 13.66 10.33 63 525695 13710 62949554
Head injury 13.60 10.33 153 525605 27243 62936021
Respiration abnormal 13.60 10.33 20 525738 6397 62956867
Hyperbilirubinaemia 13.59 10.33 48 525710 11266 62951998
Personality change 13.57 10.33 23 525735 6950 62956314
Short stature 13.37 10.33 22 525736 668 62962596
Gastroschisis 13.36 10.33 17 525741 406 62962858
Bundle branch block right 13.34 10.33 13 525745 4985 62958279
Autism spectrum disorder 13.31 10.33 25 525733 845 62962419
Visual acuity reduced 13.30 10.33 116 525642 21710 62941554
Food allergy 13.28 10.33 49 525709 11352 62951912
Amylase increased 13.23 10.33 20 525738 6325 62956939
Ulcer 13.20 10.33 296 525462 25811 62937453
Sciatica 13.16 10.33 375 525383 33949 62929315
Wrong product administered 13.15 10.33 19 525739 6122 62957142
Inadequate analgesia 13.14 10.33 4 525754 2939 62960325
Hypercholesterolaemia 13.13 10.33 249 525509 21085 62942179
Electrocardiogram QRS complex prolonged 13.08 10.33 18 525740 5920 62957344
Progressive multifocal leukoencephalopathy 13.07 10.33 59 525699 12912 62950352
Reversible cerebral vasoconstriction syndrome 13.03 10.33 3 525755 2655 62960609
Hyperthermia 13.01 10.33 36 525722 9120 62954144
Visual impairment 12.99 10.33 569 525189 83877 62879387
Device dislocation 12.98 10.33 143 525615 25562 62937702
Colorectal cancer 12.96 10.33 7 525751 3638 62959626
Anger 12.95 10.33 56 525702 12400 62950864
Nephropathy toxic 12.93 10.33 38 525720 9441 62953823
Onychomycosis 12.92 10.33 111 525647 7821 62955443
Skin toxicity 12.88 10.33 12 525746 4702 62958562
Joint noise 12.87 10.33 71 525687 4321 62958943
Pulmonary haemorrhage 12.80 10.33 25 525733 7156 62956108
Diabetes insipidus 12.80 10.33 3 525755 2622 62960642
Haemorrhage in pregnancy 12.74 10.33 40 525718 1885 62961379
Abortion incomplete 12.70 10.33 5 525753 3126 62960138
Pulmonary alveolar haemorrhage 12.62 10.33 12 525746 4656 62958608
Lymph gland infection 12.59 10.33 18 525740 482 62962782
Blood phosphorus decreased 12.57 10.33 11 525747 4442 62958822
Post-traumatic stress disorder 12.52 10.33 15 525743 5236 62958028
Exomphalos 12.51 10.33 19 525739 538 62962726
Chronic graft versus host disease 12.51 10.33 5 525753 3097 62960167
Adenovirus infection 12.49 10.33 7 525751 3564 62959700
Glomerular filtration rate decreased 12.45 10.33 63 525695 13378 62949886
Blood urea increased 12.45 10.33 149 525609 26230 62937034
Polydipsia 12.44 10.33 7 525751 3557 62959707
Hypoglycaemic coma 12.44 10.33 3 525755 2572 62960692
Nasal obstruction 12.42 10.33 37 525721 1694 62961570
Metastases to lymph nodes 12.41 10.33 31 525727 8127 62955137
Intracranial pressure increased 12.39 10.33 15 525743 5212 62958052
Blood lactic acid increased 12.35 10.33 25 525733 7061 62956203
Blood lactate dehydrogenase increased 12.32 10.33 127 525631 22989 62940275
Ankle arthroplasty 12.30 10.33 38 525720 1775 62961489
Impaired gastric emptying 12.30 10.33 44 525714 10288 62952976
Neutrophilia 12.30 10.33 11 525747 4395 62958869
Gestational hypertension 12.29 10.33 46 525712 2371 62960893
Speech disorder developmental 12.27 10.33 21 525737 659 62962605
Dermatitis acneiform 12.20 10.33 14 525744 4982 62958282
Fracture 12.19 10.33 229 525529 19355 62943909
Learning disorder 12.16 10.33 21 525737 664 62962600
Oligoarthritis 12.15 10.33 19 525739 552 62962712
Panniculitis 12.13 10.33 146 525612 11239 62952025
Squamous cell carcinoma 12.13 10.33 117 525641 8515 62954749
Product substitution issue 12.12 10.33 80 525678 15916 62947348
Product physical issue 12.12 10.33 14 525744 4966 62958298
Talipes 12.09 10.33 34 525724 1506 62961758
Congenital cerebral cyst 12.08 10.33 13 525745 258 62963006
Epistaxis 12.03 10.33 486 525272 72239 62891025
Hypertelorism 12.01 10.33 17 525741 451 62962813
Plasma cell myeloma 11.99 10.33 217 525541 35688 62927576
Hypoventilation 11.97 10.33 13 525745 4741 62958523
Premature delivery 11.94 10.33 332 525426 29949 62933315
Breast cancer metastatic 11.91 10.33 55 525703 11963 62951301
Dactylitis 11.89 10.33 48 525710 2564 62960700
Tongue disorder 11.86 10.33 137 525621 10443 62952821
Induced labour 11.75 10.33 25 525733 926 62962338
Nystagmus 11.67 10.33 21 525737 6199 62957065
Pregnancy with contraceptive device 11.63 10.33 13 525745 4681 62958583
Abdominal pain upper 11.43 10.33 1516 524242 204928 62758336
Nail injury 11.43 10.33 20 525738 639 62962625
Ingrown hair 11.43 10.33 19 525739 582 62962682
Cyst rupture 11.39 10.33 20 525738 641 62962623
Infusion site swelling 11.37 10.33 42 525716 9728 62953536
Pneumonia viral 11.37 10.33 31 525727 7891 62955373
Sleep terror 11.34 10.33 4 525754 2676 62960588
Injection site haematoma 11.34 10.33 96 525662 6736 62956528
Human anti-human antibody test 11.32 10.33 16 525742 424 62962840
Lymphatic fistula 11.30 10.33 22 525736 764 62962500
Hereditary angioedema 11.30 10.33 29 525729 7533 62955731
Ejection fraction 11.25 10.33 3 525755 2403 62960861
Contrast media allergy 11.21 10.33 3 525755 2398 62960866
Mouth ulceration 11.20 10.33 355 525403 32629 62930635
Throat tightness 11.20 10.33 142 525616 24745 62938519
Anti-neutrophil cytoplasmic antibody positive vasculitis 11.16 10.33 5 525753 2894 62960370
Pruritus genital 11.16 10.33 4 525754 2650 62960614
Bacteraemia 11.11 10.33 91 525667 17257 62946007
Disturbance in social behaviour 11.11 10.33 10 525748 3983 62959281
Cervical incompetence 11.06 10.33 19 525739 598 62962666
Haemodynamic instability 11.03 10.33 39 525719 9151 62954113
Foetal distress syndrome 10.96 10.33 30 525728 1308 62961956
Uterine perforation 10.95 10.33 26 525732 6937 62956327
Joint lock 10.95 10.33 43 525715 2268 62960996
Skin plaque 10.89 10.33 34 525724 8286 62954978
Endodontic procedure 10.88 10.33 54 525704 3153 62960111
Intervertebral disc degeneration 10.87 10.33 187 525571 15545 62947719
Potentiating drug interaction 10.87 10.33 12 525746 4344 62958920
Ileus paralytic 10.85 10.33 13 525745 4538 62958726
Hepatic necrosis 10.85 10.33 19 525739 5668 62957596
Troponin increased 10.83 10.33 45 525713 10076 62953188
Electrolyte imbalance 10.82 10.33 110 525648 19966 62943298
Trigeminal neuralgia 10.80 10.33 8 525750 3511 62959753
Catheter site pain 10.79 10.33 14 525744 4721 62958543
Infusion site pruritus 10.77 10.33 21 525737 6014 62957250
Haematocrit decreased 10.76 10.33 413 525345 38927 62924337
Maternal exposure during breast feeding 10.76 10.33 66 525692 4175 62959089
Incoherent 10.74 10.33 13 525745 4517 62958747
Atrial flutter 10.74 10.33 43 525715 9729 62953535
Neonatal respiratory distress syndrome 10.69 10.33 49 525709 2769 62960495
Infusion site erythema 10.67 10.33 55 525703 11624 62951640
Cleft lip and palate 10.67 10.33 19 525739 616 62962648
Foot operation 10.66 10.33 99 525659 7132 62956132
Bone density increased 10.64 10.33 21 525737 737 62962527
Osteoporotic fracture 10.60 10.33 60 525698 3686 62959578
Forceps delivery 10.60 10.33 11 525747 209 62963055
Syndactyly 10.59 10.33 16 525742 451 62962813
Device issue 10.59 10.33 136 525622 23645 62939619
Cholestasis of pregnancy 10.57 10.33 28 525730 1197 62962067
Bone disorder 10.53 10.33 241 525517 21085 62942179
Oropharyngeal pain 10.50 10.33 914 524844 93573 62869691
Occult blood 10.49 10.33 29 525729 1272 62961992
Hot flush 10.48 10.33 333 525425 50826 62912438
Hepatitis fulminant 10.47 10.33 8 525750 3456 62959808
Catatonia 10.45 10.33 13 525745 4464 62958800
Catheter site erythema 10.43 10.33 12 525746 4264 62959000
Myocardial ischaemia 10.42 10.33 63 525695 12796 62950468
Pleuritic pain 10.40 10.33 107 525651 7922 62955342
Rales 10.40 10.33 62 525696 12635 62950629
Terminal state 10.38 10.33 3 525755 2279 62960985
Cartilage injury 10.37 10.33 38 525720 1939 62961325
Bronchial secretion retention 10.34 10.33 5 525753 2768 62960496

FDA Adverse Event Reporting System (Male)

MedDRA adverse event termLikelihood ratioLikelihood ratio thresholdPatients taking drug having adverse eventPatients taking drug not having adverse eventPatients not taking drug having adverse eventPatients not taking drug not having adverse event
Rheumatoid arthritis 560.76 10.17 830 179573 37408 34739120
Drug abuse 370.09 10.17 40 180363 99056 34677472
Toxicity to various agents 297.57 10.17 358 180045 200004 34576524
Foetal exposure during pregnancy 273.19 10.17 606 179797 37495 34739033
Completed suicide 270.38 10.17 85 180318 98083 34678445
Arthralgia 239.41 10.17 1599 178804 168442 34608086
Psoriatic arthropathy 198.29 10.17 362 180041 19436 34757092
Drug interaction 178.48 10.17 585 179818 225361 34551167
Sickle cell anaemia with crisis 143.32 10.17 138 180265 3915 34772613
Joint swelling 141.86 10.17 649 179754 59241 34717287
Dysmorphism 130.02 10.17 117 180286 3039 34773489
Psoriasis 114.72 10.17 450 179953 38362 34738166
Intentional overdose 112.92 10.17 42 180361 43632 34732896
Musculoskeletal stiffness 104.74 10.17 498 179905 46182 34730346
Product use in unapproved indication 94.82 10.17 301 180102 117198 34659330
Premature baby 93.11 10.17 267 180136 19366 34757162
Acute kidney injury 90.94 10.17 1072 179331 303916 34472612
Blood pressure fluctuation 87.34 10.17 308 180095 24941 34751587
Enthesopathy 83.72 10.17 111 180292 4502 34772026
Synovitis 81.51 10.17 206 180197 13860 34762668
Tenosynovitis 78.41 10.17 107 180296 4463 34772065
Exposure during pregnancy 77.86 10.17 154 180249 8780 34767748
Pain 73.95 10.17 1474 178929 203201 34573327
Coma 73.77 10.17 76 180327 45602 34730926
Speech disorder developmental 72.36 10.17 72 180331 2128 34774400
Arthropathy 72.36 10.17 303 180100 26604 34749924
Overdose 72.23 10.17 235 180168 90824 34685704
C-reactive protein abnormal 70.98 10.17 146 180257 8564 34767964
Drug reaction with eosinophilia and systemic symptoms 66.85 10.17 44 180359 32968 34743560
Suicide attempt 66.73 10.17 62 180341 39054 34737474
Hepatic function abnormal 64.89 10.17 80 180323 44283 34732245
Rhabdomyolysis 63.49 10.17 163 180240 68000 34708528
Death 61.48 10.17 1575 178828 396474 34380054
Neonatal respiratory distress syndrome 61.13 10.17 89 180314 3945 34772583
Foetal anticonvulsant syndrome 61.11 10.17 50 180353 1137 34775391
Nasopharyngitis 59.95 10.17 588 179815 69380 34707148
Maternal exposure during pregnancy 58.45 10.17 97 180306 4821 34771707
Blood pressure systolic increased 58.26 10.17 254 180149 22698 34753830
Atrial septal defect 56.84 10.17 121 180282 7271 34769257
Arthritis 56.75 10.17 315 180088 31031 34745497
Hypospadias 56.52 10.17 76 180327 3125 34773403
Alanine aminotransferase abnormal 56.43 10.17 93 180310 4595 34771933
Febrile neutropenia 55.89 10.17 445 179958 136404 34640124
Serotonin syndrome 55.29 10.17 17 180386 19916 34756612
Multiple organ dysfunction syndrome 53.76 10.17 208 180195 76358 34700170
Low birth weight baby 52.46 10.17 122 180281 7783 34768745
Drug dependence 52.19 10.17 30 180373 24187 34752341
Maternal drugs affecting foetus 50.92 10.17 81 180322 3884 34772644
Autism spectrum disorder 50.81 10.17 61 180342 2235 34774293
Peripheral swelling 50.21 10.17 610 179793 75931 34700597
Learning disorder 50.05 10.17 43 180360 1048 34775480
Cryptorchism 49.79 10.17 57 180346 1984 34774544
Drug resistance 49.27 10.17 37 180366 25890 34750638
Intentional product misuse 48.98 10.17 101 180302 45510 34731018
Hypoglycaemia neonatal 47.91 10.17 54 180349 1847 34774681
Off label use 46.38 10.17 1735 178668 417789 34358739
Bradycardia 46.10 10.17 216 180187 75202 34701326
Small for dates baby 46.06 10.17 77 180326 3850 34772678
Ventricular septal defect 45.00 10.17 77 180326 3924 34772604
Rheumatoid nodule 44.63 10.17 65 180338 2882 34773646
Blood pressure systolic abnormal 44.43 10.17 76 180327 3872 34772656
Tongue disorder 44.10 10.17 90 180313 5249 34771279
Disease progression 43.85 10.17 352 180051 107725 34668803
Pain in extremity 43.57 10.17 905 179498 125608 34650920
Angioedema 43.40 10.17 79 180324 37295 34739233
Maternal exposure during breast feeding 42.69 10.17 46 180357 1495 34775033
Cytomegalovirus infection 41.61 10.17 44 180359 26091 34750437
Syndactyly 41.09 10.17 35 180368 843 34775685
Delirium 40.33 10.17 106 180297 43885 34732643
Osteoarthritis 39.77 10.17 211 180192 20431 34756097
Blood pressure diastolic abnormal 39.54 10.17 81 180322 4737 34771791
Blood pressure increased 39.27 10.17 656 179747 87446 34689082
Somnolence 38.85 10.17 376 180027 110740 34665788
Joint effusion 38.77 10.17 84 180319 5109 34771419
Hand deformity 38.41 10.17 69 180334 3656 34772872
Cardiac failure 38.03 10.17 295 180108 90953 34685575
Developmental delay 37.45 10.17 58 180345 2717 34773811
Heart rate decreased 37.22 10.17 286 180117 31459 34745069
Foot deformity 36.90 10.17 76 180327 4461 34772067
Blood pressure diastolic decreased 36.82 10.17 117 180286 8977 34767551
Depressed level of consciousness 36.47 10.17 107 180296 42734 34733794
Renal failure 36.45 10.17 465 179938 130092 34646436
Toxic epidermal necrolysis 36.11 10.17 35 180368 21611 34754917
Altered state of consciousness 35.94 10.17 39 180364 22854 34753674
Palmar-plantar erythrodysaesthesia syndrome 35.92 10.17 21 180382 16774 34759754
Psychotic disorder 35.85 10.17 44 180359 24408 34752120
Infusion related reaction 35.73 10.17 425 179978 52632 34723896
Respiratory arrest 35.57 10.17 56 180347 27987 34748541
Pancytopenia 34.83 10.17 687 179716 94470 34682058
Pulmonary fibrosis 34.73 10.17 187 180216 18209 34758319
Poisoning 34.68 10.17 10 180393 12216 34764312
Tendonitis 34.67 10.17 115 180288 9025 34767503
Basal cell carcinoma 34.55 10.17 196 180207 19462 34757066
Weight decreased 34.53 10.17 1171 179232 175130 34601398
Talipes 34.48 10.17 46 180357 1877 34774651
Exposure via breast milk 34.39 10.17 47 180356 1963 34774565
Drug intolerance 34.09 10.17 463 179940 59107 34717421
Joint laxity 33.89 10.17 23 180380 389 34776139
Sedation 33.85 10.17 35 180368 20971 34755557
Suicidal ideation 33.57 10.17 102 180301 40286 34736242
Haemoglobin decreased 33.48 10.17 838 179565 119934 34656594
Lactic acidosis 33.26 10.17 82 180321 34690 34741838
Knee arthroplasty 33.14 10.17 99 180304 7345 34769183
Grip strength decreased 33.06 10.17 59 180344 3110 34773418
Lower respiratory tract infection 32.73 10.17 277 180126 31360 34745168
Musculoskeletal pain 32.09 10.17 278 180125 31685 34744843
Red blood cell sedimentation rate increased 31.88 10.17 112 180291 9050 34767478
Immune reconstitution inflammatory syndrome 31.51 10.17 4 180399 8755 34767773
Appendicolith 30.77 10.17 4 180399 8597 34767931
Congenital hand malformation 30.50 10.17 25 180378 570 34775958
Pathogen resistance 30.35 10.17 6 180397 9476 34767052
Plagiocephaly 30.15 10.17 24 180379 524 34776004
Cardiac arrest 29.68 10.17 335 180068 95824 34680704
Hypermobility syndrome 29.14 10.17 20 180383 345 34776183
Renal impairment 28.89 10.17 330 180073 94183 34682345
Caesarean section 28.88 10.17 45 180358 2119 34774409
Jaundice neonatal 28.55 10.17 35 180368 1311 34775217
Cardiogenic shock 28.52 10.17 59 180344 26559 34749969
Dysgraphia 28.38 10.17 46 180357 2241 34774287
Acute hepatic failure 28.16 10.17 19 180384 14055 34762473
Hypoglycaemia 28.06 10.17 166 180237 54474 34722054
Polyarthritis 27.89 10.17 68 180335 4472 34772056
Hyperglycaemia 27.86 10.17 107 180296 39373 34737155
Foetal growth restriction 27.82 10.17 64 180339 4053 34772475
Fatigue 27.61 10.17 2245 178158 368408 34408120
Agitation 27.60 10.17 178 180225 57221 34719307
Language disorder 27.49 10.17 45 180358 2211 34774317
Wound 27.32 10.17 150 180253 14714 34761814
Shock 27.28 10.17 52 180351 24127 34752401
C-reactive protein increased 27.18 10.17 411 179992 53687 34722841
Intellectual disability 27.11 10.17 34 180369 1304 34775224
Acute chest syndrome 27.08 10.17 27 180376 800 34775728
Finger deformity 26.83 10.17 36 180367 1477 34775051
Diaphragmatic disorder 26.79 10.17 33 180370 1242 34775286
Drug withdrawal syndrome 26.72 10.17 38 180365 19796 34756732
Neuroleptic malignant syndrome 26.58 10.17 32 180371 17902 34758626
Large for dates baby 26.49 10.17 28 180375 890 34775638
Intentional self-injury 25.72 10.17 20 180383 13751 34762777
Astigmatism 25.69 10.17 30 180373 1067 34775461
Colitis ulcerative 25.37 10.17 159 180244 16361 34760167
Anal fistula 25.18 10.17 73 180330 5326 34771202
Rash maculo-papular 24.99 10.17 70 180333 28381 34748147
Body temperature decreased 24.94 10.17 133 180270 12901 34763627
Hepatic failure 24.74 10.17 93 180310 34438 34742090
Ankylosing spondylitis 24.45 10.17 74 180329 5530 34770998
Inflammation 24.31 10.17 238 180165 28057 34748471
Hydrops foetalis 24.23 10.17 26 180377 841 34775687
Oropharyngeal pain 24.21 10.17 285 180118 35200 34741328
Substance abuse 24.11 10.17 5 180398 7636 34768892
Skin cancer 23.91 10.17 111 180292 10186 34766342
Hypotonia neonatal 23.85 10.17 32 180371 1313 34775215
Ultrasound antenatal screen 23.67 10.17 21 180382 535 34775993
Blood pressure diastolic increased 23.49 10.17 68 180335 4957 34771571
Cytokine release syndrome 23.44 10.17 52 180351 22825 34753703
Blood creatine phosphokinase increased 23.18 10.17 136 180267 44721 34731807
Haematocrit decreased 22.99 10.17 261 180142 31955 34744573
Hyperbilirubinaemia neonatal 22.83 10.17 24 180379 758 34775770
Neurotoxicity 22.81 10.17 36 180367 17974 34758554
Respiratory failure 22.63 10.17 409 179994 108163 34668365
Tuberculosis 22.59 10.17 96 180307 8481 34768047
Selective eating disorder 22.39 10.17 36 180367 1742 34774786
Therapeutic product effect decreased 22.38 10.17 276 180127 34467 34742061
Knee deformity 22.22 10.17 22 180381 646 34775882
Motor developmental delay 22.22 10.17 22 180381 646 34775882
Otitis media 22.07 10.17 47 180356 2825 34773703
Drug withdrawal syndrome neonatal 22.01 10.17 54 180349 3565 34772963
Anaphylactic shock 22.01 10.17 30 180373 15911 34760617
Respiratory depression 22.00 10.17 31 180372 16214 34760314
Drug ineffective for unapproved indication 21.84 10.17 57 180346 23658 34752870
Venoocclusive liver disease 21.72 10.17 7 180396 7959 34768569
Dyspraxia 21.64 10.17 18 180385 419 34776109
Radiation inflammation 21.61 10.17 25 180378 880 34775648
Nasal disorder 21.55 10.17 37 180366 1891 34774637
Joint stiffness 21.53 10.17 112 180291 10761 34765767
Vitamin D deficiency 21.48 10.17 79 180324 6529 34769999
Ear infection 21.39 10.17 107 180296 10124 34766404
Trisomy 18 21.33 10.17 23 180380 748 34775780
Post procedural infection 21.07 10.17 64 180339 4792 34771736
Ear disorder 20.98 10.17 34 180369 1656 34774872
Hydrocele 20.68 10.17 38 180365 2049 34774479
Infection 20.41 10.17 614 179789 90301 34686227
Back disorder 20.36 10.17 78 180325 6573 34769955
Joint range of motion decreased 20.17 10.17 83 180320 7229 34769299
Foetal disorder 20.03 10.17 23 180380 803 34775725
Localised infection 19.81 10.17 157 180246 17430 34759098
Cleft lip and palate 19.81 10.17 24 180379 888 34775640
Arthritis infective 19.73 10.17 50 180353 3369 34773159
Cholestasis 19.69 10.17 72 180331 26876 34749652
Electrocardiogram QT prolonged 19.68 10.17 127 180276 40825 34735703
Crohn's disease 19.48 10.17 47 180356 3070 34773458
Congenital foot malformation 19.43 10.17 17 180386 425 34776103
Wrong technique in product usage process 19.19 10.17 108 180295 35878 34740650
Dyslexia 19.18 10.17 15 180388 319 34776209
Respiratory disorder neonatal 19.17 10.17 32 180371 1598 34774930
Red blood cell sedimentation rate 19.16 10.17 27 180376 1161 34775367
Strabismus 19.06 10.17 33 180370 1698 34774830
Ventricular fibrillation 19.05 10.17 58 180345 22896 34753632
Anal fissure 19.05 10.17 57 180346 4233 34772295
Loss of personal independence in daily activities 19.02 10.17 258 180145 32921 34743607
No adverse event 18.98 10.17 58 180345 22869 34753659
Malignant neoplasm progression 18.88 10.17 330 180073 87716 34688812
Umbilical hernia 18.78 10.17 60 180343 4617 34771911
Limb reduction defect 18.76 10.17 14 180389 277 34776251
Serum ferritin increased 18.75 10.17 72 180331 6074 34770454
Blood parathyroid hormone decreased 18.68 10.17 30 180373 1450 34775078
Influenza 18.64 10.17 360 180043 49306 34727222
Malignant melanoma 18.63 10.17 87 180316 8003 34768525
Cellulitis 18.59 10.17 380 180023 52571 34723957
Poor venous access 18.59 10.17 64 180339 5119 34771409
Agranulocytosis 18.50 10.17 62 180341 23759 34752769
Incorrect route of product administration 18.49 10.17 30 180373 14815 34761713
Pyrexia 18.46 10.17 1474 178929 331539 34444989
Sinusitis 18.32 10.17 308 180095 41094 34735434
Arthritis bacterial 18.27 10.17 63 180340 5043 34771485
Juvenile idiopathic arthritis 18.12 10.17 34 180369 1863 34774665
Tachycardia 18.09 10.17 318 180085 84454 34692074
Medical device implantation 17.90 10.17 19 180384 607 34775921
Vomiting 17.85 10.17 1071 179332 246550 34529978
Lung neoplasm malignant 17.83 10.17 152 180251 17243 34759285
Agitation neonatal 17.81 10.17 25 180378 1071 34775457
Fall 17.75 10.17 1245 179158 201640 34574888
Multiple congenital abnormalities 17.71 10.17 18 180385 546 34775982
Granuloma skin 17.64 10.17 27 180376 1252 34775276
Akathisia 17.54 10.17 10 180393 8099 34768429
Spinal disorder 17.48 10.17 55 180348 4197 34772331
Cerebral haemorrhage 17.48 10.17 107 180296 34830 34741698
Sleep disorder due to a general medical condition 17.36 10.17 3 180400 5218 34771310
Congenital anomaly 17.26 10.17 28 180375 1365 34775163
Immunodeficiency 17.26 10.17 65 180338 5433 34771095
Hypertelorism 17.24 10.17 18 180385 564 34775964
Proteinuria 17.02 10.17 45 180358 18597 34757931
Aspergillus infection 16.98 10.17 23 180380 12231 34764297
Lacrimal disorder 16.98 10.17 14 180389 322 34776206
Cleft lip 16.94 10.17 14 180389 323 34776205
Gastrointestinal infection 16.94 10.17 67 180336 5731 34770797
Congenital bladder anomaly 16.88 10.17 13 180390 270 34776258
Weight decrease neonatal 16.87 10.17 14 180389 325 34776203
Haematochezia 16.69 10.17 335 180068 46199 34730329
Synovial cyst 16.46 10.17 37 180366 2307 34774221
Metabolic acidosis 16.46 10.17 145 180258 43535 34732993
Attention deficit hyperactivity disorder 16.44 10.17 39 180364 2520 34774008
Pectus excavatum 16.40 10.17 12 180391 230 34776298
Renal aplasia 16.38 10.17 20 180383 746 34775782
Ankyloglossia congenital 16.33 10.17 13 180390 284 34776244
Stevens-Johnson syndrome 16.26 10.17 46 180357 18593 34757935
Joint ankylosis 16.06 10.17 29 180374 1543 34774985
Nephrolithiasis 15.83 10.17 232 180171 30101 34746427
Osteonecrosis of jaw 15.72 10.17 44 180359 17845 34758683
Withdrawal syndrome 15.67 10.17 25 180378 12430 34764098
C-reactive protein decreased 15.66 10.17 33 180370 1969 34774559
Drug level increased 15.51 10.17 60 180343 22036 34754492
Microcephaly 15.47 10.17 20 180383 791 34775737
Disseminated intravascular coagulation 15.47 10.17 59 180344 21757 34754771
Upper respiratory tract infection 15.39 10.17 248 180155 32811 34743717
Behaviour disorder 15.37 10.17 58 180345 4852 34771676
Skin injury 15.35 10.17 36 180367 2309 34774219
Abdominal discomfort 15.34 10.17 411 179992 59424 34717104
Second primary malignancy 15.31 10.17 11 180392 7875 34768653
Patent ductus arteriosus 15.31 10.17 45 180358 3309 34773219
Haemangioma congenital 15.30 10.17 16 180387 502 34776026
Aggression 15.28 10.17 128 180275 38836 34737692
Weight increased 15.27 10.17 606 179797 92427 34684101
Scoliosis 15.24 10.17 40 180363 2753 34773775
Suspected suicide 15.20 10.17 3 180400 4745 34771783
Hepatocellular injury 15.16 10.17 61 180342 22150 34754378
Ventricular tachycardia 15.15 10.17 78 180325 26501 34750027
Anti-cyclic citrullinated peptide antibody positive 15.14 10.17 31 180372 1812 34774716
Injection site pain 15.07 10.17 284 180119 38721 34737807
Respiratory rate increased 15.05 10.17 95 180308 9799 34766729
Hyperammonaemia 15.04 10.17 7 180396 6360 34770168
Latent tuberculosis 15.03 10.17 26 180377 1337 34775191
Cardio-respiratory arrest 14.98 10.17 198 180205 55075 34721453
Arthrodesis 14.97 10.17 15 180388 447 34776081
Hepatic enzyme increased 14.91 10.17 284 180119 38796 34737732
Hypokalaemia 14.89 10.17 211 180192 58003 34718525
Abortion spontaneous 14.86 10.17 14 180389 386 34776142
Sexual dysfunction 14.78 10.17 7 180396 6296 34770232
Oxygen saturation decreased 14.47 10.17 372 180031 53446 34723082
Bone cyst 14.45 10.17 28 180375 1572 34774956
Oesophageal fibrosis 14.40 10.17 10 180393 176 34776352
Hernia pain 14.37 10.17 12 180391 281 34776247
Fistula discharge 14.35 10.17 20 180383 851 34775677
Arnold-Chiari malformation 14.34 10.17 13 180390 341 34776187
Neck mass 14.29 10.17 28 180375 1585 34774943
Tooth malformation 14.16 10.17 10 180393 181 34776347
Acute graft versus host disease 14.09 10.17 8 180395 6495 34770033
Bradycardia neonatal 14.02 10.17 21 180382 955 34775573
Kidney infection 13.92 10.17 60 180343 5334 34771194
Bronchiolitis 13.91 10.17 42 180361 3134 34773394
Electrocardiogram QRS complex prolonged 13.89 10.17 4 180399 4890 34771638
Myoclonus 13.86 10.17 35 180368 14690 34761838
Cystitis haemorrhagic 13.79 10.17 6 180397 5673 34770855
Diverticular perforation 13.74 10.17 44 180359 3390 34773138
Developmental coordination disorder 13.70 10.17 10 180393 191 34776337
Adenovirus infection 13.68 10.17 5 180398 5252 34771276
Autoscopy 13.60 10.17 11 180392 246 34776282
Heart rate irregular 13.60 10.17 133 180270 15674 34760854
Septic arthritis staphylococcal 13.59 10.17 15 180388 501 34776027
Melaena 13.53 10.17 117 180286 35263 34741265
Foetal distress syndrome 13.48 10.17 22 180381 1078 34775450
Panniculitis 13.48 10.17 31 180372 1963 34774565
Foetal heart rate deceleration abnormality 13.47 10.17 15 180388 506 34776022
Maternal exposure timing unspecified 13.46 10.17 13 180390 370 34776158
Haemangioma 13.39 10.17 30 180373 1867 34774661
Nodule 13.33 10.17 70 180333 6749 34769779
Blood test abnormal 13.25 10.17 71 180332 6900 34769628
Hepatitis E antibody positive 13.23 10.17 11 180392 256 34776272
Hypotension 13.21 10.17 975 179428 220674 34555854
Polydactyly 13.19 10.17 23 180380 1190 34775338
Pneumonia 12.99 10.17 2095 178308 360532 34415996
Low set ears 12.99 10.17 14 180389 455 34776073
Pleuritic pain 12.94 10.17 44 180359 3497 34773031
Vitamin B12 deficiency 12.94 10.17 48 180355 3983 34772545
Maternal exposure before pregnancy 12.79 10.17 18 180385 773 34775755
Respiratory tract infection viral 12.68 10.17 35 180368 2482 34774046
Inguinal hernia 12.65 10.17 75 180328 7566 34768962
Hypertriglyceridaemia 12.60 10.17 15 180388 8433 34768095
Red blood cell sedimentation rate abnormal 12.59 10.17 44 180359 3545 34772983
Appendicitis 12.59 10.17 37 180366 14770 34761758
Educational problem 12.55 10.17 15 180388 547 34775981
Fistula 12.55 10.17 69 180334 6771 34769757
BK virus infection 12.52 10.17 7 180396 5731 34770797
Acute generalised exanthematous pustulosis 12.45 10.17 10 180393 6766 34769762
Vascular insufficiency 12.42 10.17 12 180391 342 34776186
Gamma-glutamyltransferase increased 12.40 10.17 94 180309 29137 34747391
Headache 12.37 10.17 1199 179204 199436 34577092
Pleural fibrosis 12.28 10.17 24 180379 1356 34775172
Blood insulin increased 12.24 10.17 12 180391 348 34776180
Acute respiratory distress syndrome 12.24 10.17 81 180322 25888 34750640
Nerve compression 12.21 10.17 41 180362 3238 34773290
Bronchopulmonary aspergillosis 12.19 10.17 37 180366 14622 34761906
Anal atresia 12.18 10.17 11 180392 287 34776241
Back pain 12.18 10.17 756 179647 121033 34655495
Psychomotor retardation 12.17 10.17 44 180359 3606 34772922
Cardiotoxicity 12.16 10.17 7 180396 5641 34770887
Hepatitis E virus test positive 12.15 10.17 11 180392 288 34776240
Hallucination 12.02 10.17 190 180213 51308 34725220
Spina bifida 11.99 10.17 12 180391 357 34776171
Hypermetropia 11.94 10.17 14 180389 500 34776028
Abdominal adhesions 11.90 10.17 25 180378 1488 34775040
Transplant rejection 11.78 10.17 22 180381 10289 34766239
Rheumatoid lung 11.76 10.17 19 180384 923 34775605
Neck pain 11.74 10.17 190 180213 25159 34751369
Ear malformation 11.72 10.17 11 180392 302 34776226
Hyperthermia 11.71 10.17 23 180380 10554 34765974
Abnormal behaviour 11.71 10.17 78 180325 24891 34751637
Pharyngeal disorder 11.70 10.17 17 180386 752 34775776
Nail pitting 11.66 10.17 11 180392 304 34776224
Chronic graft versus host disease 11.65 10.17 4 180399 4369 34772159
Nail bed bleeding 11.62 10.17 12 180391 371 34776157
Posterior reversible encephalopathy syndrome 11.59 10.17 21 180382 9933 34766595
Mobility decreased 11.51 10.17 219 180184 29909 34746619
Glycosylated haemoglobin increased 11.49 10.17 26 180377 11334 34765194
Product quality issue 11.49 10.17 47 180356 16988 34759540
Gangrene neonatal 11.48 10.17 9 180394 192 34776336
Therapy partial responder 11.45 10.17 20 180383 9596 34766932
Palindromic rheumatism 11.44 10.17 9 180394 193 34776335
Joint instability 11.34 10.17 13 180390 453 34776075
Cytomegalovirus viraemia 11.28 10.17 13 180390 7417 34769111
Neutropenia neonatal 11.21 10.17 16 180387 696 34775832
Blood phosphorus increased 11.20 10.17 14 180389 7707 34768821
Necrotising fasciitis streptococcal 11.18 10.17 8 180395 148 34776380
Contusion 11.17 10.17 256 180147 36108 34740420
Urticaria 11.17 10.17 241 180162 62136 34714392
Cardiac murmur 11.15 10.17 74 180329 7763 34768765
Irritability 11.15 10.17 78 180325 24612 34751916
Loss of consciousness 11.14 10.17 333 180070 82334 34694194
Vitamin B complex deficiency 11.14 10.17 12 180391 390 34776138
Mania 11.13 10.17 20 180383 9491 34767037
Peripheral artery thrombosis 11.09 10.17 32 180371 2328 34774200
Fine motor skill dysfunction 11.08 10.17 27 180376 1775 34774753
Gross motor delay 11.06 10.17 11 180392 325 34776203
Pneumonia aspiration 11.03 10.17 151 180252 41752 34734776
Thrombotic microangiopathy 11.02 10.17 24 180379 10606 34765922
Progressive multifocal leukoencephalopathy 11.01 10.17 21 180382 9743 34766785
Excessive cerumen production 11.00 10.17 11 180392 327 34776201
Red blood cell count decreased 10.96 10.17 211 180192 28879 34747649
End stage renal disease 10.95 10.17 18 180385 8843 34767685
Congenital hydronephrosis 10.86 10.17 16 180387 717 34775811
Major depression 10.84 10.17 5 180398 4567 34771961
Hypocalcaemia 10.83 10.17 77 180326 24212 34752316
Dystonia 10.82 10.17 25 180378 10820 34765708
Congenital genital malformation 10.82 10.17 8 180395 156 34776372
Diabetic ketoacidosis 10.80 10.17 52 180351 17980 34758548
Neonatal infection 10.77 10.17 12 180391 405 34776123
Cholelithiasis 10.74 10.17 161 180242 20987 34755541
Hallucination, auditory 10.70 10.17 29 180374 11888 34764640
Pharyngitis 10.70 10.17 74 180329 7870 34768658
Myasthenia gravis 10.70 10.17 12 180391 6928 34769600
Injection site bruising 10.69 10.17 79 180324 8584 34767944
Dysstasia 10.68 10.17 103 180300 12092 34764436
Haemolysis 10.67 10.17 75 180328 8019 34768509
Visuospatial deficit 10.65 10.17 7 180396 112 34776416
Hypertransaminasaemia 10.65 10.17 8 180395 5598 34770930
Bone erosion 10.62 10.17 45 180358 3970 34772558
Unresponsive to stimuli 10.62 10.17 91 180312 27478 34749050
Pulmonary artery stenosis congenital 10.58 10.17 13 180390 488 34776040
Pulmonary pain 10.55 10.17 21 180382 1203 34775325
Osteolysis 10.54 10.17 38 180365 3110 34773418
Blood folate increased 10.52 10.17 10 180393 279 34776249
Neonatal seizure 10.52 10.17 13 180390 491 34776037
Pulmonary alveolar haemorrhage 10.51 10.17 14 180389 7498 34769030
Obsessive-compulsive disorder 10.49 10.17 8 180395 5556 34770972
Meningeal disorder 10.45 10.17 11 180392 348 34776180
Gastroschisis 10.44 10.17 8 180395 165 34776363
Exposure to toxic agent 10.43 10.17 3 180400 3672 34772856
Acute graft versus host disease in skin 10.43 10.17 7 180396 5194 34771334
Diverticulum 10.43 10.17 68 180335 7091 34769437
Myopia 10.41 10.17 20 180383 1116 34775412
Kyphosis 10.40 10.17 21 180382 1215 34775313
Injection site haemorrhage 10.35 10.17 86 180317 9682 34766846
Asphyxia 10.34 10.17 12 180391 6823 34769705
Frequent bowel movements 10.23 10.17 106 180297 12681 34763847
Personality change 10.20 10.17 7 180396 5132 34771396

FDA Adverse Event Reporting System (Geriatric)

MedDRA adverse event termLikelihood ratioLikelihood ratio thresholdPatients taking drug having adverse eventPatients taking drug not having adverse eventPatients not taking drug having adverse eventPatients not taking drug not having adverse event
Rheumatoid arthritis 1243.64 9.75 3643 532365 204827 79003553
Completed suicide 1158.72 9.75 144 535864 245623 78962757
Toxicity to various agents 1005.45 9.75 816 535192 420724 78787656
Arthropathy 989.63 9.75 3025 532983 174086 79034294
Pemphigus 965.51 9.75 2094 533914 97488 79110892
Systemic lupus erythematosus 962.43 9.75 2355 533653 118794 79089586
Joint swelling 948.62 9.75 4148 531860 284498 78923882
Hand deformity 937.43 9.75 2123 533885 101796 79106584
Synovitis 911.66 9.75 2648 533360 148086 79060294
Glossodynia 842.30 9.75 2029 533979 101308 79107072
Drug abuse 757.66 9.75 99 535909 162592 79045788
Arthralgia 756.95 9.75 6484 529524 565319 78643061
Anti-cyclic citrullinated peptide antibody positive 720.34 9.75 1672 534336 81471 79126909
Wound 705.15 9.75 2044 533964 114135 79094245
Maternal exposure during pregnancy 667.45 9.75 2228 533780 134310 79074070
Pericarditis 650.09 9.75 1852 534156 102384 79105996
Infusion related reaction 641.60 9.75 3154 532854 227083 78981297
Abdominal discomfort 595.87 9.75 3286 532722 247441 78960939
Pain 557.13 9.75 7192 528816 696610 78511770
Drug interaction 546.27 9.75 1241 534767 413942 78794438
Discomfort 534.41 9.75 1958 534050 123659 79084721
Swelling 534.21 9.75 2869 533139 213842 78994538
Alopecia 523.03 9.75 2992 533016 228363 78980017
Therapeutic product effect decreased 517.13 9.75 2328 533680 161535 79046845
Duodenal ulcer perforation 455.90 9.75 1220 534788 64991 79143389
Contraindicated product administered 455.69 9.75 2182 533826 155356 79053024
Helicobacter infection 452.64 9.75 1257 534751 68447 79139933
Musculoskeletal stiffness 450.39 9.75 2345 533663 172663 79035717
Rheumatoid factor positive 433.80 9.75 1124 534884 58715 79149665
Intentional overdose 420.20 9.75 98 535910 105862 79102518
Nasopharyngitis 409.69 9.75 3016 532992 250865 78957515
Drug intolerance 402.75 9.75 3096 532912 261023 78947357
Death 398.95 9.75 2208 533800 564306 78644074
Psoriatic arthropathy 394.51 9.75 1288 534720 76711 79131669
Hepatic enzyme increased 392.62 9.75 2331 533677 180279 79028101
Acute kidney injury 349.59 9.75 2054 533954 517350 78691030
Febrile neutropenia 327.08 9.75 662 535346 230337 78978043
Exposure during pregnancy 317.49 9.75 1435 534573 99697 79108683
Impaired healing 302.76 9.75 1280 534728 86375 79122005
Peripheral swelling 266.46 9.75 2878 533130 266739 78941641
Hypersensitivity 263.23 9.75 2808 533200 259431 78948949
Overdose 260.62 9.75 528 535480 183678 79024702
Cardiac arrest 256.75 9.75 478 535530 171618 79036762
Depressed level of consciousness 256.01 9.75 167 535841 96485 79111895
C-reactive protein abnormal 253.85 9.75 809 535199 47558 79160822
Muscle injury 251.92 9.75 809 535199 47752 79160628
Sinusitis 250.60 9.75 2204 533804 193297 79015083
Folliculitis 249.62 9.75 880 535128 54500 79153880
Suicide attempt 248.74 9.75 123 535885 82809 79125571
Treatment failure 244.49 9.75 1971 534037 168515 79039865
Irritable bowel syndrome 241.21 9.75 942 535066 61299 79147081
Lower respiratory tract infection 236.22 9.75 1583 534425 127637 79080743
Blister 228.92 9.75 1481 534527 117995 79090385
Sleep disorder due to general medical condition, insomnia type 221.75 9.75 721 535287 42835 79165545
Red blood cell sedimentation rate abnormal 218.18 9.75 454 535554 20509 79187871
Arthritis 214.59 9.75 1415 534593 113465 79094915
Knee arthroplasty 213.99 9.75 709 535299 42539 79165841
Sickle cell anaemia with crisis 213.55 9.75 265 535743 7657 79200723
Product use issue 211.98 9.75 2250 533758 207572 79000808
Rhabdomyolysis 205.28 9.75 234 535774 102897 79105483
Bradycardia 204.40 9.75 374 535634 135183 79073197
Drug reaction with eosinophilia and systemic symptoms 197.68 9.75 92 535916 64152 79144228
Weight increased 194.59 9.75 2777 533231 274609 78933771
Hip arthroplasty 193.07 9.75 604 535404 35152 79173228
Blood pressure fluctuation 191.76 9.75 927 535081 66218 79142162
Osteoarthritis 190.98 9.75 1120 534888 86189 79122191
Sedation 179.79 9.75 62 535946 51833 79156547
Lactic acidosis 173.86 9.75 131 535877 70228 79138152
Respiratory arrest 173.11 9.75 85 535923 57465 79150915
Malignant neoplasm progression 168.46 9.75 419 535589 135571 79072809
Renal failure 168.25 9.75 736 535272 200232 79008148
Rheumatic fever 166.30 9.75 495 535513 28030 79180350
Hepatic function abnormal 164.70 9.75 149 535859 72958 79135422
Cardiac failure 162.30 9.75 517 535491 154325 79054055
Disease progression 161.84 9.75 663 535345 183699 79024681
Sopor 158.71 9.75 18 535990 32992 79175388
Multiple organ dysfunction syndrome 158.09 9.75 359 535649 119887 79088493
Coma 150.54 9.75 279 535729 100370 79108010
Contusion 150.46 9.75 1596 534412 147180 79061200
Fibromyalgia 150.30 9.75 840 535168 63500 79144880
Infection 148.93 9.75 2367 533641 239345 78969035
Hyponatraemia 148.45 9.75 652 535356 177196 79031184
Neutropenia 147.75 9.75 1230 534778 286480 78921900
Fatigue 144.81 9.75 7633 528375 922094 78286286
Psoriasis 144.63 9.75 1065 534943 88522 79119858
Serotonin syndrome 144.00 9.75 61 535947 44966 79163414
Ill-defined disorder 140.16 9.75 839 535169 65036 79143344
Abortion spontaneous 140.01 9.75 477 535531 29030 79179350
Blood pressure systolic increased 139.25 9.75 848 535160 66138 79142242
Pregnancy 138.95 9.75 447 535561 26404 79181976
Swollen joint count increased 138.57 9.75 403 535605 22524 79185856
Red blood cell sedimentation rate increased 136.78 9.75 642 535366 45300 79163080
Blood pressure systolic abnormal 136.46 9.75 335 535673 16912 79191468
Drug resistance 133.70 9.75 58 535950 42155 79166225
Blood pressure diastolic abnormal 133.30 9.75 355 535653 18847 79189533
Hypotension 129.96 9.75 2129 533879 438188 78770192
Renal impairment 128.32 9.75 584 535424 157199 79051181
Agitation 127.61 9.75 302 535706 99413 79108967
Intentional product misuse 126.81 9.75 282 535726 94883 79113497
Somnolence 126.17 9.75 1014 534994 237967 78970413
Respiratory failure 125.85 9.75 707 535301 180204 79028176
Condition aggravated 125.67 9.75 4326 531682 496798 78711582
Cardio-respiratory arrest 125.47 9.75 346 535662 108164 79100216
Cytomegalovirus infection 123.76 9.75 66 535942 42578 79165802
Hypoglycaemia 123.50 9.75 316 535692 101278 79107102
Constipation 123.30 9.75 1261 534747 281789 78926591
Joint effusion 122.99 9.75 331 535677 17683 79190697
Rash 121.27 9.75 4894 531114 573464 78634916
Electrocardiogram QT prolonged 121.13 9.75 267 535741 90119 79118261
Hepatic failure 119.51 9.75 141 535867 61071 79147309
Product use in unapproved indication 117.60 9.75 1095 534913 249264 78959116
Drug dependence 111.30 9.75 68 535940 40701 79167679
Grip strength decreased 111.29 9.75 362 535646 21507 79186873
Inflammation 109.36 9.75 1036 534972 92717 79115663
Pain in extremity 109.11 9.75 3215 532793 361323 78847057
Intentional self-injury 106.79 9.75 42 535966 32377 79176003
Hyperglycaemia 104.26 9.75 196 535812 70139 79138241
Neoplasm progression 104.20 9.75 116 535892 51566 79156814
Altered state of consciousness 103.96 9.75 85 535923 43737 79164643
Tachycardia 101.47 9.75 738 535270 177030 79031350
Poisoning 100.90 9.75 23 535985 25249 79183131
Musculoskeletal pain 100.64 9.75 1092 534916 101262 79107118
Injection site erythema 99.77 9.75 881 535127 77316 79131064
Angioedema 99.12 9.75 228 535780 75807 79132573
Stomatitis 99.10 9.75 1460 534548 145297 79063083
C-reactive protein increased 98.99 9.75 1313 534695 127714 79080666
Blood pressure diastolic decreased 98.71 9.75 434 535574 29782 79178598
Osteoporosis 98.26 9.75 662 535346 53450 79154930
Enthesopathy 96.69 9.75 230 535778 11378 79197002
Thrombocytopenia 96.22 9.75 1231 534777 264028 78944352
Metabolic acidosis 95.52 9.75 263 535745 82266 79126114
Foot deformity 94.58 9.75 366 535642 23708 79184672
Rheumatoid nodule 94.53 9.75 295 535713 17143 79191237
Respiratory depression 92.33 9.75 35 535973 27595 79180785
Disseminated intravascular coagulation 90.79 9.75 65 535943 35777 79172603
Disability assessment scale score increased 90.53 9.75 114 535894 3344 79205036
Cytokine release syndrome 90.25 9.75 66 535942 35932 79172448
Blood cholesterol increased 88.79 9.75 907 535101 82813 79125567
Gastrointestinal disorder 88.18 9.75 1230 534778 120975 79087405
Shock 87.51 9.75 98 535910 43450 79164930
Live birth 87.16 9.75 301 535707 18443 79189937
Bone erosion 86.86 9.75 291 535717 17556 79190824
Hyperhidrosis 85.92 9.75 630 535378 150862 79057518
Heart rate decreased 85.50 9.75 784 535224 69532 79138848
Tenosynovitis 83.27 9.75 262 535746 15292 79193088
Intentional product use issue 82.38 9.75 1459 534549 150653 79057727
Cholestasis 81.91 9.75 140 535868 51969 79156411
Juvenile idiopathic arthritis 81.41 9.75 128 535880 4635 79203745
Injection site reaction 80.95 9.75 638 535370 54147 79154233
Joint range of motion decreased 80.71 9.75 439 535569 32843 79175537
Blood creatine phosphokinase increased 79.98 9.75 206 535802 65884 79142496
Joint stiffness 78.67 9.75 507 535501 40323 79168057
Drug ineffective 77.89 9.75 8347 527661 1072566 78135814
Hepatocellular injury 76.54 9.75 126 535882 47467 79160913
Injection site pruritus 76 9.75 516 535492 41767 79166613
Ventricular tachycardia 75.21 9.75 103 535905 41832 79166548
Hyperkalaemia 74.24 9.75 457 535551 113941 79094439
Polyarthritis 74.23 9.75 215 535793 11987 79196393
Cognitive disorder 72.86 9.75 234 535774 69692 79138688
Anaphylactic shock 72.34 9.75 81 535927 35915 79172465
Drug ineffective for unapproved indication 72.29 9.75 147 535861 51091 79157289
Syncope 72.22 9.75 814 535194 178635 79029745
Joint destruction 72.10 9.75 137 535871 5788 79202592
Ventricular fibrillation 71.98 9.75 65 535943 31861 79176519
Cerebral haemorrhage 71.93 9.75 177 535831 57496 79150884
Loss of personal independence in daily activities 71.80 9.75 1027 534981 101553 79106827
Sedation complication 71.79 9.75 10 535998 15659 79192721
Palmar-plantar erythrodysaesthesia syndrome 71.72 9.75 70 535938 33064 79175316
Encephalopathy 70.60 9.75 225 535783 67172 79141208
Injection site pain 68.75 9.75 1241 534767 128597 79079783
Anaemia 68.70 9.75 2375 533633 442640 78765740
Neuroleptic malignant syndrome 68.48 9.75 51 535957 27508 79180872
Localised infection 68.40 9.75 460 535548 37115 79171265
Cardiogenic shock 68.31 9.75 110 535898 41804 79166576
Hypoxia 68.27 9.75 410 535598 102833 79105547
Pulmonary fibrosis 68.11 9.75 519 535489 43593 79164787
Caesarean section 67.89 9.75 212 535796 12323 79196057
Neurotoxicity 67.76 9.75 71 535937 32447 79175933
Basal cell carcinoma 67.71 9.75 457 535551 36918 79171462
Drug withdrawal syndrome 66.67 9.75 81 535927 34637 79173743
Acute hepatic failure 65.90 9.75 63 535945 30050 79178330
Seizure 64.91 9.75 886 535122 187948 79020432
Mobility decreased 64.07 9.75 1166 534842 121009 79087371
Leukopenia 62.99 9.75 491 535517 116022 79092358
Hallucination 62.95 9.75 329 535679 85416 79122964
Joint laxity 62.52 9.75 78 535930 2266 79206114
Myocardial infarction 62.18 9.75 867 535141 183262 79025118
Vomiting 61.86 9.75 3755 532253 662073 78546307
Cardiac failure congestive 60.87 9.75 637 535371 141765 79066615
Neuropathy peripheral 60.03 9.75 633 535375 140672 79067708
Blood pressure increased 59.61 9.75 1851 534157 209509 78998871
Mydriasis 59.54 9.75 22 535986 17621 79190759
Disturbance in attention 58.70 9.75 162 535846 50639 79157741
Blood pressure diastolic increased 58.69 9.75 223 535785 14319 79194061
Immune reconstitution inflammatory syndrome 58.55 9.75 11 535997 13830 79194550
Gestational diabetes 58.27 9.75 130 535878 6163 79202217
Tendonitis 58.23 9.75 315 535693 23515 79184865
Agranulocytosis 57.90 9.75 136 535872 44894 79163486
Orthostatic hypotension 57.78 9.75 189 535819 55975 79152405
Disability 57.52 9.75 248 535760 16872 79191508
Injection site swelling 57.03 9.75 525 535483 46607 79161773
Nodule 56.90 9.75 305 535703 22689 79185691
Adverse event 56.69 9.75 637 535371 59577 79148803
Hypothermia 56.64 9.75 42 535966 22704 79185676
Ascites 56.55 9.75 288 535720 75274 79133106
Type 2 diabetes mellitus 56.40 9.75 610 535398 56512 79151868
Myoclonus 55.85 9.75 62 535946 27598 79180782
Sepsis 55.82 9.75 1381 534627 268047 78940333
Venoocclusive liver disease 55.15 9.75 7 536001 11764 79196616
Red blood cell sedimentation rate 54.98 9.75 118 535890 5447 79202933
Tongue disorder 54.51 9.75 212 535796 13763 79194617
Psychotic disorder 54.07 9.75 124 535884 41278 79167102
Hypokalaemia 53.85 9.75 664 535344 143376 79065004
Abnormal behaviour 53.53 9.75 102 535906 36319 79172061
Drug level increased 53.22 9.75 117 535891 39534 79168846
Tremor 53.19 9.75 813 535195 169270 79039110
Neutrophil count decreased 52.65 9.75 392 535616 93567 79114813
Cerebral infarction 52.52 9.75 146 535862 45530 79162850
Gamma-glutamyltransferase increased 52.20 9.75 190 535818 54490 79153890
Inappropriate antidiuretic hormone secretion 52.02 9.75 60 535948 26253 79182127
Disorientation 51.82 9.75 231 535777 62545 79145835
Alanine aminotransferase abnormal 51.80 9.75 154 535854 8713 79199667
Blood creatinine increased 51.32 9.75 733 535275 154324 79054056
Body temperature decreased 51.20 9.75 381 535627 31764 79176616
Restlessness 50.97 9.75 152 535856 46340 79162040
Delirium 50.86 9.75 346 535662 84281 79124099
Ejection fraction decreased 50.67 9.75 97 535911 34480 79173900
No adverse event 50.53 9.75 109 535899 37083 79171297
Substance abuse 49.95 9.75 6 536002 10520 79197860
Second primary malignancy 49.95 9.75 17 535991 14333 79194047
Pathogen resistance 49.91 9.75 17 535991 14325 79194055
Posterior reversible encephalopathy syndrome 49.75 9.75 62 535946 26219 79182161
Aspergillus infection 49.52 9.75 34 535974 19127 79189253
Suicidal ideation 48.98 9.75 306 535702 76034 79132346
Oropharyngeal pain 48.33 9.75 1017 534991 108336 79100044
Injection site bruising 48.24 9.75 454 535554 40548 79167832
Diabetic ketoacidosis 48.04 9.75 98 535910 34024 79174356
Miosis 47.96 9.75 23 535985 15766 79192614
Extrapyramidal disorder 47.84 9.75 49 535959 22630 79185750
Dehydration 47.71 9.75 1286 534722 246901 78961479
Torsade de pointes 47.64 9.75 36 535972 19276 79189104
Laryngitis 47.63 9.75 224 535784 15815 79192565
Creatinine renal clearance decreased 47.42 9.75 35 535973 18967 79189413
Respiratory distress 47.36 9.75 216 535792 58123 79150257
Ear infection 47.09 9.75 394 535614 34038 79174342
Femur fracture 47.00 9.75 431 535577 38221 79170159
Melaena 46.76 9.75 230 535778 60660 79147720
Myalgia 46.01 9.75 925 535083 184716 79023664
Tenderness 45.81 9.75 294 535714 23348 79185032
Speech disorder 45.75 9.75 199 535809 54246 79154134
Akathisia 45.65 9.75 16 535992 13243 79195137
Thrombotic microangiopathy 45.54 9.75 41 535967 20128 79188252
Synovial cyst 45.39 9.75 160 535848 9905 79198475
Rash maculo-papular 45.30 9.75 208 535800 55870 79152510
Proteinuria 45.21 9.75 94 535914 32408 79175972
Withdrawal syndrome 45.16 9.75 69 535939 26785 79181595
Bronchopulmonary aspergillosis 44.98 9.75 50 535958 22244 79186136
Bursitis 44.25 9.75 401 535607 35443 79172937
Aggression 44.21 9.75 184 535824 50774 79157606
Asphyxia 44.20 9.75 12 535996 11708 79196672
Blood glucose increased 44.12 9.75 527 535481 114448 79093932
Irritability 44.05 9.75 136 535872 41008 79167372
Latent tuberculosis 43.89 9.75 80 535928 3273 79205107
Haematotoxicity 43.61 9.75 25 535983 15494 79192886
Acute respiratory distress syndrome 43.48 9.75 151 535857 43916 79164464
Drug use disorder 43.44 9.75 4 536004 8647 79199733
Brain oedema 43.37 9.75 64 535944 25199 79183181
Transplant rejection 43.31 9.75 40 535968 19397 79188983
Dystonia 43.17 9.75 48 535960 21351 79187029
Eosinophilia 43 9.75 158 535850 45187 79163193
Blood parathyroid hormone decreased 42.88 9.75 162 535846 10374 79198006
Appendicolith 42.82 9.75 4 536004 8547 79199833
Toxic epidermal necrolysis 42.50 9.75 155 535853 44426 79163954
Osteonecrosis of jaw 42.06 9.75 149 535859 43077 79165303
Wrong technique in product usage process 41.97 9.75 307 535701 73568 79134812
Loss of consciousness 41.86 9.75 836 535172 167107 79041273
Tumour lysis syndrome 41.73 9.75 60 535948 23879 79184501
Exposure to toxic agent 41.59 9.75 6 536002 9152 79199228
Dyspnoea 41.31 9.75 5088 530920 851937 78356443
Myelosuppression 41.18 9.75 136 535872 40160 79168220
Acute graft versus host disease 41.10 9.75 9 535999 10158 79198222
Neck deformity 41.02 9.75 56 535952 1781 79206599
Skin ulcer 40.65 9.75 549 535459 53601 79154779
Fracture 40.35 9.75 268 535740 21533 79186847
Unintentional medical device removal 40.29 9.75 3 536005 7709 79200671
Acute chest syndrome 40.13 9.75 51 535957 1510 79206870
Unresponsive to stimuli 39.86 9.75 216 535792 55572 79152808
Granuloma skin 39.80 9.75 144 535864 9030 79199350
Coagulopathy 39.27 9.75 118 535890 35888 79172492
Tuberculosis 39.26 9.75 204 535804 14994 79193386
Nausea 39.18 9.75 5741 530267 951455 78256925
Acute generalised exanthematous pustulosis 39.05 9.75 35 535973 17219 79191161
Off label use 39.00 9.75 5425 530583 901790 78306590
Facet joint syndrome 38.96 9.75 165 535843 11137 79197243
Vision blurred 38.89 9.75 490 535518 105408 79102972
Haemophagocytic lymphohistiocytosis 38.79 9.75 54 535954 21783 79186597
Exostosis 38.63 9.75 219 535789 16639 79191741
Lip dry 38.48 9.75 205 535803 15213 79193167
Atrial fibrillation 38.37 9.75 1024 534984 196862 79011518
Ankylosing spondylitis 38.12 9.75 173 535835 12032 79196348
Anaphylactic reaction 38.10 9.75 369 535639 83374 79125006
Arrhythmia 38.08 9.75 248 535760 61024 79147356
Maternal exposure before pregnancy 37.89 9.75 88 535920 4285 79204095
Therapeutic response decreased 37.52 9.75 645 535363 66208 79142172
Peripheral venous disease 37.33 9.75 208 535800 15701 79192679
Ischaemic stroke 37.28 9.75 107 535901 33024 79175356
Wheelchair user 37.26 9.75 108 535900 6024 79202356
BK virus infection 37.24 9.75 7 536001 8797 79199583
Coronary artery disease 37.24 9.75 272 535736 65202 79143178
Psychomotor hyperactivity 37.16 9.75 35 535973 16814 79191566
Status epilepticus 36.91 9.75 70 535938 24971 79183409
Joint injury 36.88 9.75 347 535661 30988 79177392
Joint dislocation 36.82 9.75 217 535791 16722 79191658
Multiple fractures 36.55 9.75 128 535880 7898 79200482
Injection site rash 36.48 9.75 226 535782 17728 79190652
Neck mass 36.40 9.75 87 535921 4317 79204063
Pre-eclampsia 36.23 9.75 117 535891 6924 79201456
Anxiety 36.06 9.75 1336 534672 247176 78961204
Toxic skin eruption 35.86 9.75 59 535949 22234 79186146
Hyperthermia 35.79 9.75 41 535967 17996 79190384
Fear of injection 35.61 9.75 121 535887 7353 79201027
Gastroenteritis viral 35.49 9.75 287 535721 24544 79183836
Panniculitis 35.45 9.75 171 535837 12200 79196180
Haemorrhage intracranial 35.39 9.75 77 535931 26116 79182264
Arthritis infective 35.18 9.75 129 535879 8142 79200238
Maternal exposure timing unspecified 35.18 9.75 102 535906 5690 79202690
Dysarthria 35.14 9.75 288 535720 67334 79141046
Clostridium difficile colitis 35.06 9.75 106 535902 32177 79176203
Pancreatitis acute 34.92 9.75 193 535815 49411 79158969
Accidental overdose 34.91 9.75 142 535866 39439 79168941
Dyskinesia 34.44 9.75 169 535839 44604 79163776
Colorectal cancer 34.26 9.75 8 536000 8639 79199741
Balance disorder 34.25 9.75 463 535545 98394 79109986
Pyrexia 34.21 9.75 4017 531991 674692 78533688
Limb deformity 34.18 9.75 75 535933 3515 79204865
Premature labour 34.14 9.75 129 535879 8261 79200119
Spinal stenosis 34.14 9.75 202 535806 15589 79192791
Erythema multiforme 34.08 9.75 41 535967 17610 79190770
Mania 33.61 9.75 44 535964 18216 79190164
Forced expiratory volume decreased 33.51 9.75 6 536002 7808 79200572
Ulcer 33.35 9.75 328 535680 29644 79178736
Deep vein thrombosis postoperative 33.28 9.75 152 535856 10600 79197780
Premature rupture of membranes 33.22 9.75 80 535928 3989 79204391
Bradyphrenia 33.09 9.75 15 535993 10625 79197755
Mental status changes 33.07 9.75 289 535719 66670 79141710
Lupus-like syndrome 33.07 9.75 182 535826 13675 79194705
Chronic kidney disease 32.91 9.75 285 535723 65869 79142511
Tachypnoea 32.91 9.75 108 535900 31955 79176425
Bronchospasm 32.83 9.75 74 535934 24785 79183595
Smear cervix abnormal 32.55 9.75 60 535948 2476 79205904
Premature delivery 32.34 9.75 269 535739 23198 79185182
Face oedema 32.30 9.75 90 535918 28046 79180334
Pulmonary oedema 32.16 9.75 409 535599 87845 79120535
Acidosis 32.07 9.75 52 535956 19710 79188670
Retinitis 32.01 9.75 97 535911 5546 79202834
Sciatica 31.97 9.75 353 535655 32869 79175511
Bone disorder 31.85 9.75 229 535779 18884 79189496
Stevens-Johnson syndrome 31.79 9.75 145 535863 39021 79169359
Asthma 31.73 9.75 679 535329 134416 79073964
Anti-cyclic citrullinated peptide antibody 31.72 9.75 99 535909 5753 79202627
Asthenia 31.62 9.75 2985 533023 508704 78699676
Rotator cuff repair 31.61 9.75 50 535958 1820 79206560
Wound infection 31.47 9.75 272 535736 23719 79184661
Disease recurrence 31.39 9.75 171 535837 43938 79164442
Malignant mediastinal neoplasm 31.39 9.75 43 535965 1372 79207008
Skin papilloma 31.37 9.75 99 535909 5787 79202593
Stress cardiomyopathy 31.36 9.75 18 535990 11148 79197232
Graft versus host disease 31.09 9.75 33 535975 14993 79193387
Blood bilirubin increased 30.91 9.75 290 535718 65942 79142438
Influenza 30.89 9.75 1113 534895 128493 79079887
Adjustment disorder with depressed mood 30.82 9.75 132 535876 8954 79199426
Haemoptysis 30.72 9.75 235 535773 55764 79152616
Scleritis 30.71 9.75 81 535927 4275 79204105
Drug tolerance decreased 30.67 9.75 170 535838 12808 79195572
Poor venous access 30.56 9.75 218 535790 17931 79190449
Platelet count decreased 30.40 9.75 1037 534971 193627 79014753
Gastrointestinal haemorrhage 29.80 9.75 760 535248 146959 79061421
Skin cancer 29.74 9.75 188 535820 14852 79193528
Leukocytosis 29.55 9.75 171 535837 43284 79165096
Blood calcium decreased 29.43 9.75 112 535896 31707 79176673
Herpes zoster 29.43 9.75 827 535181 92256 79116124
Adenovirus infection 29.41 9.75 10 535998 8437 79199943
Fear 29.40 9.75 65 535943 21921 79186459
Angina pectoris 29.37 9.75 215 535793 51517 79156863
Jaundice 29.21 9.75 224 535784 53125 79155255
Cytopenia 29.16 9.75 58 535950 20325 79188055
Cytomegalovirus viraemia 29.03 9.75 26 535982 12795 79195585
Emotional distress 28.97 9.75 154 535854 39815 79168565
Tenosynovitis stenosans 28.97 9.75 64 535944 3014 79205366
Shock haemorrhagic 28.76 9.75 57 535951 20003 79188377
Blood alkaline phosphatase increased 28.76 9.75 281 535727 63383 79144997
Cerebrovascular accident 28.70 9.75 809 535199 154483 79053897
Hallucination, auditory 28.65 9.75 60 535948 20633 79187747
Lymphocyte count decreased 28.58 9.75 193 535815 47096 79161284
Obesity 28.41 9.75 361 535647 34764 79173616
Foot fracture 28.20 9.75 248 535760 21733 79186647
Pulmonary embolism 28.08 9.75 909 535099 170745 79037635
Synovial fluid analysis 28.03 9.75 54 535954 2305 79206075
Dislocation of vertebra 27.91 9.75 116 535892 7764 79200616
Interstitial lung disease 27.90 9.75 561 535447 112039 79096341
Hallucination, visual 27.88 9.75 119 535889 32610 79175770
Klebsiella infection 27.80 9.75 39 535969 15681 79192699
Hepatitis B reactivation 27.74 9.75 4 536004 6104 79202276
Urinary retention 27.71 9.75 245 535763 56385 79151995
Weight decreased 27.50 9.75 2758 533250 352440 78855940
Liver injury 27.49 9.75 534 535474 56080 79152300
Pulmonary alveolar haemorrhage 27.45 9.75 22 535986 11435 79196945
Bronchitis 27.34 9.75 1106 534902 129538 79078842
Pneumatosis intestinalis 27.24 9.75 5 536003 6392 79201988
Anuria 27.20 9.75 63 535945 20900 79187480
Aphasia 27.12 9.75 193 535815 46539 79161841
Acute myeloid leukaemia 27.11 9.75 111 535897 30774 79177606
Hypomagnesaemia 27.10 9.75 194 535814 46717 79161663
Mouth ulceration 27.09 9.75 385 535623 38009 79170371
Rheumatoid lung 26.99 9.75 76 535932 4169 79204211
Hyperbilirubinaemia 26.99 9.75 80 535928 24438 79183942
Sinus tachycardia 26.87 9.75 142 535866 36766 79171614
Chest discomfort 26.84 9.75 714 535294 137330 79071050
Diarrhoea 26.80 9.75 5367 530641 875122 78333258
Acute graft versus host disease in skin 26.78 9.75 9 535999 7649 79200731
Product quality issue 26.75 9.75 127 535881 33813 79174567
Dysphagia 26.65 9.75 621 535387 121515 79086865
Haemorrhage 26.65 9.75 441 535567 90677 79117703
Hemiplegia 26.48 9.75 37 535971 14902 79193478
Muscle rigidity 26.41 9.75 59 535949 19823 79188557
Antinuclear antibody positive 26.28 9.75 114 535894 7776 79200604
Pemphigoid 26.09 9.75 39 535969 15276 79193104
Immunodeficiency 26.09 9.75 242 535766 21526 79186854
Septic shock 26.07 9.75 627 535381 122174 79086206
Hypertransaminasaemia 26.03 9.75 25 535983 11899 79196481
Metastases to bone 25.96 9.75 81 535927 24346 79184034
Subdural haematoma 25.74 9.75 116 535892 31318 79177062
Polyneuropathy 25.73 9.75 80 535928 24071 79184309
Glycosylated haemoglobin increased 25.71 9.75 57 535951 19203 79189177
Sexual dysfunction 25.66 9.75 10 535998 7753 79200627
Rhinorrhoea 25.49 9.75 681 535327 75393 79132987
Dermatitis acneiform 25.47 9.75 18 535990 9975 79198405
Blood pressure decreased 25.42 9.75 493 535515 98973 79109407
Malignant melanoma 25.37 9.75 178 535830 14563 79193817
Metastases to liver 25.33 9.75 101 535907 28213 79180167
Loose body in joint 25.25 9.75 37 535971 1258 79207122
Multiple sclerosis relapse 25.18 9.75 196 535812 46337 79162043
Nocardiosis 25.15 9.75 4 536004 5675 79202705
Labelled drug-drug interaction medication error 25.14 9.75 98 535910 27552 79180828
Muscle twitching 25.01 9.75 84 535924 24680 79183700
Device difficult to use 24.89 9.75 32 535976 13353 79195027
Diabetes insipidus 24.81 9.75 3 536005 5234 79203146
Hyperammonaemia 24.51 9.75 23 535985 11070 79197310
Electrocardiogram QRS complex prolonged 24.49 9.75 22 535986 10811 79197569
Hemiparesis 24.43 9.75 130 535878 33603 79174777
Rebound effect 24.40 9.75 9 535999 7217 79201163
Hyperuricaemia 24.31 9.75 26 535982 11773 79196607
Synovial disorder 24.31 9.75 46 535962 1937 79206443
Pancytopenia 24.21 9.75 1354 534654 164391 79043989
Joint noise 24.15 9.75 70 535938 3904 79204476
Cystitis haemorrhagic 24.07 9.75 16 535992 9156 79199224
Temperature regulation disorder 24.03 9.75 5 536003 5848 79202532
Hepatotoxicity 23.90 9.75 225 535783 51127 79157253
Injection site warmth 23.86 9.75 176 535832 14631 79193749
Acute myocardial infarction 23.81 9.75 369 535639 76667 79131713
Chronic graft versus host disease 23.66 9.75 8 536000 6773 79201607
Accidental exposure to product 23.65 9.75 119 535889 31203 79177177
Oral herpes 23.42 9.75 285 535723 27169 79181211
Finger deformity 23.39 9.75 106 535902 7368 79201012
Breast cancer stage I 23.21 9.75 8 536000 6692 79201688
Ileus 23.13 9.75 94 535914 26117 79182263
Oxygen saturation decreased 23.11 9.75 1075 534933 127972 79080408
Haematocrit decreased 22.94 9.75 557 535451 60755 79147625
Product administration error 22.92 9.75 123 535885 31723 79176657
Myocardial ischaemia 22.85 9.75 91 535917 25428 79182952
Pleuritic pain 22.68 9.75 131 535877 10021 79198359
White blood cell count decreased 22.67 9.75 1034 534974 187254 79021126
Hyperthyroidism 22.66 9.75 75 535933 22134 79186246
Hydrops foetalis 22.55 9.75 27 535981 751 79207629
Hyperlactacidaemia 22.52 9.75 5 536003 5590 79202790
Lower limb fracture 22.49 9.75 247 535761 22968 79185412
Cardiomyopathy 22.49 9.75 108 535900 28666 79179714
Haematoma 22.49 9.75 233 535775 51962 79156418
Pulmonary arterial hypertension 22.44 9.75 106 535902 28260 79180120
Cardiac failure chronic 22.43 9.75 25 535983 11110 79197270
Cyanosis 22.42 9.75 90 535918 25092 79183288
Peripheral sensory neuropathy 22.39 9.75 33 535975 13000 79195380
Vertigo 22.34 9.75 328 535680 68754 79139626
Febrile bone marrow aplasia 22.33 9.75 33 535975 12987 79195393
Fracture delayed union 22.31 9.75 46 535962 2064 79206316
Device use error 22.10 9.75 10 535998 7091 79201289
Pancreatitis 22.04 9.75 326 535682 68249 79140131
Cardiotoxicity 22.01 9.75 30 535978 12209 79196171
Sinus bradycardia 22.00 9.75 91 535917 25156 79183224
Product prescribing error 21.87 9.75 194 535814 44619 79163761
Acute coronary syndrome 21.82 9.75 71 535937 21062 79187318
Ultrasound antenatal screen 21.67 9.75 25 535983 668 79207712
Injury 21.64 9.75 678 535330 76818 79131562
Infective pulmonary exacerbation of cystic fibrosis 21.63 9.75 33 535975 12818 79195562
Compartment syndrome 21.58 9.75 4 536004 5078 79203302
Hepatitis acute 21.57 9.75 45 535963 15497 79192883
Cleft lip and palate 21.52 9.75 25 535983 673 79207707
Nephropathy toxic 21.50 9.75 68 535940 20351 79188029
Cardiac failure acute 21.39 9.75 61 535947 18868 79189512
Hyperprolactinaemia 21.38 9.75 3 536005 4673 79203707
Purpura 21.29 9.75 64 535944 19463 79188917
Human antichimeric antibody positive 21.29 9.75 39 535969 1602 79206778
Hypophosphataemia 21.19 9.75 66 535942 19847 79188533
Blood lactic acid increased 21.18 9.75 33 535975 12711 79195669
Tubulointerstitial nephritis 21.18 9.75 160 535848 38075 79170305
Affective disorder 21.18 9.75 15 535993 8304 79200076
Oliguria 21.17 9.75 49 535959 16260 79192120
Respiratory disorder 21.10 9.75 196 535812 44660 79163720
Post procedural infection 21.10 9.75 140 535868 11244 79197136
Autoimmune disorder 21.09 9.75 187 535821 16425 79191955
Pseudomonas infection 21.05 9.75 71 535937 20832 79187548
Potentiating drug interaction 21.05 9.75 17 535991 8802 79199578
Tardive dyskinesia 21.01 9.75 24 535984 10547 79197833
Multiple-drug resistance 20.99 9.75 17 535991 8791 79199589
Acute respiratory failure 20.93 9.75 278 535730 59263 79149117
Hypernatraemia 20.77 9.75 41 535967 14410 79193970
Venoocclusive disease 20.76 9.75 3 536005 4570 79203810
Injection site haemorrhage 20.69 9.75 282 535726 27588 79180792
Metastases to central nervous system 20.62 9.75 50 535958 16325 79192055
Hepatic encephalopathy 20.50 9.75 88 535920 24078 79184302
Polyuria 20.40 9.75 44 535964 14970 79193410
Ingrown hair 20.31 9.75 25 535983 716 79207664
Pruritus genital 20.23 9.75 3 536005 4483 79203897
Hepatitis cholestatic 20.17 9.75 39 535969 13813 79194567
Drug tolerance 20.08 9.75 113 535895 8562 79199818
Anhedonia 19.96 9.75 44 535964 14854 79193526
Decreased appetite 19.79 9.75 2007 534001 340411 78867969
Epstein-Barr virus infection 19.79 9.75 42 535966 14374 79194006
Graft versus host disease in skin 19.78 9.75 8 536000 6065 79202315
Therapy partial responder 19.71 9.75 56 535952 17341 79191039
Body height below normal 19.67 9.75 43 535965 2010 79206370
Haemodynamic instability 19.66 9.75 56 535952 17326 79191054
Pneumonia aspiration 19.61 9.75 324 535684 66643 79141737
Respiratory acidosis 19.59 9.75 28 535980 11172 79197208
Ankle arthroplasty 19.47 9.75 36 535972 1489 79206891
Enterocolitis 19.33 9.75 43 535965 14469 79193911
Pulmonary haemorrhage 19.28 9.75 44 535964 14673 79193707
Atrioventricular block 19.20 9.75 41 535967 14000 79194380
Postoperative wound infection 19.17 9.75 151 535857 12810 79195570
Lip swelling 19.14 9.75 179 535829 40732 79167648
Haematemesis 19.12 9.75 242 535766 52022 79156358
Trisomy 18 19.09 9.75 22 535986 587 79207793
Pleural effusion 19.08 9.75 790 535218 144472 79063908
Surgery 19.06 9.75 318 535690 32448 79175932
Glomerular filtration rate decreased 19.06 9.75 83 535925 22619 79185761
Jaundice cholestatic 18.97 9.75 29 535979 11255 79197125
Nasal polyps 18.94 9.75 13 535995 7314 79201066
General physical health deterioration 18.87 9.75 2120 533888 273118 78935262
Bacteraemia 18.84 9.75 136 535872 32688 79175692
Pulseless electrical activity 18.82 9.75 42 535966 14118 79194262
Mental disorder 18.79 9.75 128 535880 31174 79177206
Skin necrosis 18.71 9.75 195 535813 17892 79190488
Hypocalcaemia 18.70 9.75 230 535778 49694 79158686
Haemoglobin decreased 18.69 9.75 1735 534273 220384 78987996
Hepatitis fulminant 18.61 9.75 13 535995 7249 79201131
Endophthalmitis 18.57 9.75 10 535998 6418 79201962
Bladder cancer 18.54 9.75 68 535940 19458 79188922
Myocarditis 18.52 9.75 79 535929 21654 79186726
Foot operation 18.46 9.75 82 535926 5651 79202729
Virologic failure 18.45 9.75 3 536005 4188 79204192
Transplant dysfunction 18.41 9.75 13 535995 7208 79201172
Catatonia 18.37 9.75 19 535989 8737 79199643
Parkinsonism 18.34 9.75 54 535954 16530 79191850
Lymphopenia 18.32 9.75 125 535883 30432 79177948
Prescribed overdose 18.28 9.75 357 535651 37526 79170854
Cytomegalovirus chorioretinitis 18.27 9.75 7 536001 5483 79202897
Urticaria 18.26 9.75 1038 534970 184163 79024217
Obstructive airways disorder 18.22 9.75 130 535878 31329 79177051
Cytomegalovirus infection reactivation 18.19 9.75 19 535989 8697 79199683
Heparin-induced thrombocytopenia 18.16 9.75 23 535985 9659 79198721
Progressive multifocal leukoencephalopathy 18.10 9.75 74 535934 20526 79187854
Flushing 18.10 9.75 453 535555 87815 79120565
Onychomycosis 18.07 9.75 106 535902 8155 79200225
Musculoskeletal disorder 18.01 9.75 222 535786 21226 79187154
Eosinophil count increased 17.98 9.75 57 535951 17048 79191332
Atrial tachycardia 17.98 9.75 13 535995 7120 79201260
Sleep terror 17.91 9.75 4 536004 4454 79203926
Breast feeding 17.89 9.75 23 535985 689 79207691
Heart rate irregular 17.87 9.75 314 535694 32365 79176015
Device related infection 17.84 9.75 146 535862 34148 79174232
Multiple drug therapy 17.77 9.75 3 536005 4075 79204305
Rash pruritic 17.77 9.75 618 535390 71011 79137369
Short stature 17.77 9.75 23 535985 694 79207686
Cholangitis 17.72 9.75 37 535971 12739 79195641
Cyst 17.68 9.75 156 535852 13684 79194696
Ventricular arrhythmia 17.64 9.75 20 535988 8820 79199560
Normal newborn 17.63 9.75 94 535914 6978 79201402
Polyhydramnios 17.60 9.75 37 535971 1683 79206697
Foetal distress syndrome 17.53 9.75 19 535989 473 79207907
Rhinitis allergic 17.47 9.75 35 535973 12234 79196146
Cushingoid 17.42 9.75 117 535891 9435 79198945
Therapy non-responder 17.41 9.75 773 535235 91532 79116848
Renal injury 17.38 9.75 57 535951 16870 79191510
Hepatocellular carcinoma 17.37 9.75 21 535987 9000 79199380
Endodontic procedure 17.33 9.75 49 535959 2694 79205686
Generalised tonic-clonic seizure 17.32 9.75 200 535808 43710 79164670
Procedural pain 17.26 9.75 88 535920 22996 79185384
Placental disorder 17.25 9.75 26 535982 907 79207473
Personality change 17.23 9.75 26 535982 10144 79198236
Oesophageal carcinoma 17.22 9.75 30 535978 11054 79197326
Device leakage 17.21 9.75 29 535979 10827 79197553
Hypoalbuminaemia 17.19 9.75 79 535929 21218 79187162
Palpitations 17.17 9.75 686 535322 125924 79082456
Immune effector cell-associated neurotoxicity syndrome 17.04 9.75 9 535999 5839 79202541
Accidental death 16.94 9.75 4 536004 4287 79204093
Delusion 16.94 9.75 75 535933 20348 79188032
Maternal exposure during breast feeding 16.87 9.75 49 535959 2736 79205644
Hepatic cirrhosis 16.86 9.75 329 535679 34577 79173803
Hypothyroidism 16.86 9.75 249 535759 52143 79156237
Toxic encephalopathy 16.84 9.75 32 535976 11408 79196972
Hydrocephalus 16.84 9.75 21 535987 8879 79199501
Antibody test positive 16.80 9.75 49 535959 2743 79205637
Subarachnoid haemorrhage 16.78 9.75 96 535912 24369 79184011
International normalised ratio increased 16.78 9.75 437 535571 84284 79124096
Knee operation 16.75 9.75 81 535927 5785 79202595
Dizziness 16.74 9.75 3201 532807 523240 78685140
Left ventricular dysfunction 16.73 9.75 70 535938 19291 79189089
Polydipsia 16.70 9.75 12 535996 6593 79201787
Pulmonary congestion 16.68 9.75 110 535898 26990 79181390
Bradypnoea 16.65 9.75 10 535998 6042 79202338
Gastric haemorrhage 16.64 9.75 49 535959 15001 79193379
Bone pain 16.55 9.75 269 535739 55473 79152907
Red blood cell count decreased 16.54 9.75 505 535503 57008 79151372
Hyperlipidaemia 16.52 9.75 105 535903 25988 79182392
Pharyngitis streptococcal 16.50 9.75 126 535882 10588 79197792
End stage renal disease 16.44 9.75 36 535972 12184 79196196
Radiation inflammation 16.42 9.75 25 535983 880 79207500
Hypoxic-ischaemic encephalopathy 16.37 9.75 17 535991 7803 79200577
Aspartate aminotransferase increased 16.35 9.75 763 535245 137878 79070502
Paranoia 16.34 9.75 71 535937 19361 79189019
Colitis ulcerative 16.29 9.75 326 535682 34416 79173964
Injection site urticaria 16.09 9.75 144 535864 12682 79195698
Toothache 16.04 9.75 205 535803 19765 79188615
Diaphragmatic disorder 16.03 9.75 36 535972 1714 79206666
Sickle cell anaemia 15.99 9.75 21 535987 643 79207737
Acute pulmonary oedema 15.98 9.75 46 535962 14184 79194196
Ileus paralytic 15.91 9.75 25 535983 9595 79198785
Nightmare 15.90 9.75 105 535903 25756 79182624
Hepatic cancer 15.90 9.75 29 535979 10500 79197880
COVID-19 pneumonia 15.85 9.75 121 535887 28728 79179652
Type 1 diabetes mellitus 15.70 9.75 14 535994 6905 79201475
Induced labour 15.69 9.75 24 535984 848 79207532
Transaminases increased 15.60 9.75 249 535759 51494 79156886
Cross sensitivity reaction 15.60 9.75 3 536005 3709 79204671
Upper respiratory tract infection 15.58 9.75 756 535252 90412 79117968
Product administered to patient of inappropriate age 15.52 9.75 9 535999 5544 79202836
COVID-19 15.49 9.75 884 535124 156790 79051590
Metastases to lung 15.49 9.75 66 535942 18097 79190283
Fluid retention 15.49 9.75 354 535654 69455 79138925
Disturbance in social behaviour 15.47 9.75 7 536001 4963 79203417
Stillbirth 15.43 9.75 60 535948 3895 79204485
Lacrimal disorder 15.31 9.75 18 535990 491 79207889
Dactylitis 15.27 9.75 47 535961 2710 79205670
Paralysis 15.24 9.75 42 535966 13135 79195245
Blood lactate dehydrogenase increased 15.22 9.75 179 535829 38991 79169389
Tuberculin test positive 15.22 9.75 54 535954 3354 79205026
Lipase increased 15.20 9.75 58 535950 16408 79191972
Blood phosphorus increased 15.18 9.75 29 535979 10318 79198062
Lymph gland infection 15.18 9.75 19 535989 554 79207826
Cellulitis 15.16 9.75 887 535121 108173 79100207
Respiration abnormal 15.13 9.75 18 535990 7770 79200610
Injection site extravasation 15.06 9.75 114 535894 9555 79198825
Anal fissure 15.05 9.75 96 535912 7607 79200773
Dysgeusia 15.03 9.75 282 535726 56895 79151485
Atrioventricular block complete 15.02 9.75 59 535949 16551 79191829
Renal disorder 15.01 9.75 196 535812 41909 79166471
Hypercapnia 14.98 9.75 23 535985 8912 79199468
Alcohol interaction 14.96 9.75 7 536001 4867 79203513
Pulmonary hypertension 14.96 9.75 230 535778 47850 79160530
Walking aid user 14.89 9.75 118 535890 10030 79198350
Depressed mood 14.71 9.75 233 535775 48247 79160133
Incoherent 14.71 9.75 18 535990 7674 79200706
Coordination abnormal 14.71 9.75 63 535945 17249 79191131
Osteoporotic fracture 14.69 9.75 62 535946 4178 79204202
Strongyloidiasis 14.68 9.75 4 536004 3894 79204486
Hypoaesthesia 14.64 9.75 1398 534610 177954 79030426
Blood urea increased 14.64 9.75 235 535773 48555 79159825
Erectile dysfunction 14.63 9.75 50 535958 14614 79193766
Tooth infection 14.58 9.75 192 535816 18640 79189740
Salivary hypersecretion 14.54 9.75 48 535960 14176 79194204
Schizophrenia 14.51 9.75 54 535954 15386 79192994
Ligament rupture 14.49 9.75 53 535955 3341 79205039
Personality disorder 14.48 9.75 12 535996 6134 79202246
Wound infection pseudomonas 14.47 9.75 33 535975 1588 79206792
Foetal exposure during pregnancy 14.46 9.75 77 535931 5713 79202667
Device expulsion 14.43 9.75 108 535900 25753 79182627
C-reactive protein 14.39 9.75 69 535939 4910 79203470
Clear cell renal cell carcinoma 14.35 9.75 44 535964 2532 79205848
C-reactive protein decreased 14.33 9.75 45 535963 2623 79205757
Skin toxicity 14.33 9.75 21 535987 8293 79200087
Tooth disorder 14.32 9.75 252 535756 25981 79182399
Diabetes mellitus 14.32 9.75 409 535599 77981 79130399
Joint lock 14.31 9.75 51 535957 3174 79205206
Lymphatic fistula 14.31 9.75 22 535986 781 79207599
Amylase increased 14.29 9.75 34 535974 11175 79197205
Lower respiratory tract congestion 14.28 9.75 59 535949 3938 79204442
Aplasia 14.23 9.75 19 535989 7801 79200579
Hyperpyrexia 14.22 9.75 12 535996 6080 79202300
Kidney infection 14.19 9.75 216 535792 21635 79186745
Bradykinesia 14.18 9.75 20 535988 8023 79200357
Acute lymphocytic leukaemia recurrent 14.17 9.75 7 536001 4717 79203663
Right ventricular failure 14.15 9.75 96 535912 23401 79184979
Osteopenia 14.12 9.75 187 535821 18177 79190203
Bone density abnormal 14.11 9.75 49 535959 3011 79205369
Drug screen positive 14.08 9.75 12 535996 6051 79202329
Coronary artery bypass 14.08 9.75 12 535996 6050 79202330
Hypomania 14.07 9.75 18 535990 7526 79200854
Bronchial secretion retention 14.05 9.75 5 536003 4099 79204281
Haemorrhage in pregnancy 13.99 9.75 30 535978 1384 79206996
Intervertebral disc degeneration 13.96 9.75 165 535843 15620 79192760
Myopathy 13.94 9.75 81 535927 20482 79187898
Drug dose omission by device 13.76 9.75 13 535995 6237 79202143
Visual acuity reduced 13.76 9.75 129 535879 29340 79179040
Anti-neutrophil cytoplasmic antibody positive vasculitis 13.72 9.75 4 536004 3725 79204655
Pneumonia bacterial 13.72 9.75 75 535933 19256 79189124
Hypertriglyceridaemia 13.71 9.75 42 535966 12698 79195682
Immunosuppression 13.71 9.75 139 535869 12664 79195716
Acute graft versus host disease in intestine 13.70 9.75 5 536003 4036 79204344
Spinal osteoarthritis 13.70 9.75 174 535834 16753 79191627
Diabetes mellitus inadequate control 13.70 9.75 101 535907 24163 79184217
Renal tubular disorder 13.69 9.75 14 535994 6472 79201908
Acute myeloid leukaemia recurrent 13.66 9.75 3 536005 3380 79205000
Persecutory delusion 13.66 9.75 8 536000 4901 79203479
Anger 13.65 9.75 64 535944 17098 79191282
Prostatic specific antigen increased 13.65 9.75 31 535977 10355 79198025
Depression 13.59 9.75 1263 534745 215527 78992853
Femoral hernia incarcerated 13.53 9.75 22 535986 820 79207560
Dyslipidaemia 13.51 9.75 37 535971 11596 79196784
Laryngospasm 13.46 9.75 5 536003 3992 79204388
Aphthous ulcer 13.41 9.75 173 535835 16716 79191664
Intracranial pressure increased 13.41 9.75 22 535986 8300 79200080
Haematuria 13.38 9.75 356 535652 68480 79139900
Lip blister 13.36 9.75 45 535963 2722 79205658
Joint warmth 13.33 9.75 32 535976 1592 79206788
Feeling abnormal 13.30 9.75 906 535102 158293 79050087
Chronic sinusitis 13.28 9.75 44 535964 12982 79195398
Metastasis 13.26 9.75 16 535992 6864 79201516
Breast abscess 13.25 9.75 30 535978 1436 79206944
Alcohol abuse 13.23 9.75 10 535998 5353 79203027
Cervical incompetence 13.21 9.75 17 535991 510 79207870
Skin exfoliation 13.20 9.75 276 535732 54824 79153556
Circulatory collapse 13.19 9.75 176 535832 37492 79170888
Bone marrow failure 13.15 9.75 253 535755 50854 79157526
Oligoarthritis 13.13 9.75 20 535988 704 79207676
Kidney transplant rejection 13.13 9.75 31 535977 10215 79198165
Panic attack 13.10 9.75 102 535906 24114 79184266
Capillary leak syndrome 13.07 9.75 5 536003 3920 79204460
Anticholinergic syndrome 13.06 9.75 4 536004 3607 79204773
Incorrect route of product administration 13.05 9.75 161 535847 34768 79173612
Appendicitis 13.00 9.75 84 535924 20710 79187670
Blood folate increased 12.98 9.75 17 535991 519 79207861
Small for dates baby 12.95 9.75 16 535992 460 79207920
Systemic inflammatory response syndrome 12.92 9.75 37 535971 11428 79196952
Joint ankylosis 12.87 9.75 38 535970 2142 79206238
Coronary arterial stent insertion 12.81 9.75 13 535995 6031 79202349
Cerebral haematoma 12.79 9.75 21 535987 7921 79200459
Human anti-human antibody test 12.79 9.75 15 535993 408 79207972
Cyst rupture 12.77 9.75 19 535989 655 79207725
Generalised oedema 12.76 9.75 100 535908 23609 79184771
Abortion threatened 12.73 9.75 15 535993 410 79207970
Hypertonia 12.73 9.75 18 535990 7214 79201166
Sleep disorder due to a general medical condition 12.73 9.75 51 535957 14226 79194154
Road traffic accident 12.72 9.75 384 535624 43280 79165100
Arthropod bite 12.70 9.75 99 535909 8372 79200008
Drug abuser 12.67 9.75 13 535995 6000 79202380
Immunosuppressant drug level increased 12.64 9.75 26 535982 9001 79199379
Psychomotor skills impaired 12.62 9.75 10 535998 5227 79203153
Dry skin 12.61 9.75 354 535654 67641 79140739
Pharyngitis 12.59 9.75 216 535792 22159 79186221
Myofascial pain syndrome 12.49 9.75 36 535972 2001 79206379
Placental insufficiency 12.49 9.75 25 535983 1098 79207282
Type I hypersensitivity 12.48 9.75 7 536001 4391 79203989
Threatened labour 12.41 9.75 18 535990 606 79207774
Pulmonary tuberculosis 12.40 9.75 93 535915 7772 79200608
Brain injury 12.38 9.75 38 535970 11479 79196901
Hepatitis C 12.35 9.75 40 535968 11885 79196495
Nail injury 12.33 9.75 18 535990 610 79207770
Pain in jaw 12.32 9.75 227 535781 45924 79162456
Gestational hypertension 12.30 9.75 34 535974 1845 79206535
Respiratory tract infection viral 12.30 9.75 59 535949 4200 79204180
Pulmonary pain 12.22 9.75 61 535947 4412 79203968
Diplopia 12.22 9.75 155 535853 33311 79175069
Defaecation disorder 12.21 9.75 19 535989 682 79207698
Frequent bowel movements 12.17 9.75 272 535736 29267 79179113
Candida infection 12.16 9.75 182 535826 38032 79170348
Mitochondrial toxicity 12.10 9.75 3 536005 3111 79205269
Sudden death 12.10 9.75 95 535913 22416 79185964
Intestinal ischaemia 12.09 9.75 47 535961 13223 79195157
Complications of transplanted kidney 12.07 9.75 15 535993 6351 79202029
Oesophageal fibrosis 12.04 9.75 10 535998 176 79208204
Drug specific antibody 12.04 9.75 42 535966 2586 79205794
Anal fistula 12.04 9.75 84 535924 6860 79201520
Human herpesvirus 6 infection 12.03 9.75 11 535997 5359 79203021
Acute lung injury 12.02 9.75 3 536005 3097 79205283
Vascular purpura 12.01 9.75 3 536005 3095 79205285
Rash erythematous 11.97 9.75 296 535712 57473 79150907
Pneumothorax 11.97 9.75 127 535881 28196 79180184
Renal tubular necrosis 11.95 9.75 109 535899 24930 79183450
Palmoplantar keratoderma 11.94 9.75 5 536003 3711 79204669
Spondylitis 11.87 9.75 63 535945 4668 79203712
Congestive cardiomyopathy 11.87 9.75 40 535968 11740 79196640
Adverse drug reaction 11.87 9.75 553 535455 65839 79142541
Alanine aminotransferase increased 11.84 9.75 936 535072 161634 79046746
Abortion incomplete 11.82 9.75 3 536005 3061 79205319
Nephrolithiasis 11.81 9.75 454 535554 52837 79155543
Angina unstable 11.80 9.75 64 535944 16463 79191917
Reversible cerebral vasoconstriction syndrome 11.78 9.75 3 536005 3054 79205326
Drug hypersensitivity 11.78 9.75 1796 534212 297120 78911260
Spinal disorder 11.77 9.75 113 535895 10147 79198233
Carotid artery thrombosis 11.75 9.75 3 536005 3050 79205330
Hypoventilation 11.73 9.75 19 535989 7205 79201175
Psychiatric decompensation 11.70 9.75 6 536002 3957 79204423
Iodine allergy 11.69 9.75 17 535991 574 79207806
Dry eye 11.63 9.75 328 535680 36603 79171777
Deformity 11.62 9.75 107 535901 9498 79198882
Tooth abscess 11.62 9.75 163 535845 16047 79192333
Hypercholesterolaemia 11.60 9.75 219 535789 22876 79185504
Neck pain 11.58 9.75 619 535389 74798 79133582
Arthritis bacterial 11.54 9.75 103 535905 9063 79199317
Ketoacidosis 11.54 9.75 22 535986 7832 79200548
Troponin increased 11.43 9.75 79 535929 19176 79189204
Benign ovarian tumour 11.43 9.75 13 535995 342 79208038
Sensitisation 11.39 9.75 4 536004 3307 79205073
Muscle spasticity 11.37 9.75 91 535917 21384 79186996
Gastric cancer 11.36 9.75 33 535975 10146 79198234
Deep vein thrombosis 11.33 9.75 681 535327 120238 79088142
Long QT syndrome 11.32 9.75 14 535994 5941 79202439
Metastases to meninges 11.32 9.75 5 536003 3596 79204784
Complication of device removal 11.31 9.75 6 536002 3883 79204497
Cell death 11.29 9.75 9 535999 4690 79203690
Presyncope 11.26 9.75 201 535807 40853 79167527
Skin neoplasm excision 11.23 9.75 23 535985 1027 79207353
Hernia 11.22 9.75 169 535839 16890 79191490
Cartilage injury 11.19 9.75 29 535979 1514 79206866
Pulmonary function test abnormal 11.19 9.75 7 536001 4137 79204243
Bacterial sepsis 11.16 9.75 24 535984 8174 79200206
Bone density increased 11.13 9.75 20 535988 809 79207571
Lethargy 11.12 9.75 440 535568 80852 79127528
Mass 11.07 9.75 172 535836 17300 79191080
Neutrophilia 11.05 9.75 23 535985 7928 79200452
Accidental exposure to product by child 11.03 9.75 3 536005 2923 79205457
Vascular device infection 10.97 9.75 34 535974 10242 79198138
Foetal death 10.97 9.75 92 535916 7952 79200428
Epstein-Barr virus associated lymphoproliferative disorder 10.95 9.75 5 536003 3527 79204853
Inadequate analgesia 10.95 9.75 9 535999 4620 79203760
Neurologic neglect syndrome 10.92 9.75 3 536005 2904 79205476
Skin ulcer haemorrhage 10.92 9.75 16 535992 544 79207836
Ischaemic cardiomyopathy 10.92 9.75 22 535986 7673 79200707
Cholestasis of pregnancy 10.92 9.75 22 535986 971 79207409
Pseudomembranous colitis 10.90 9.75 12 535996 5362 79203018
Tooth fracture 10.86 9.75 122 535886 11408 79196972
Hepatitis B 10.84 9.75 25 535983 8307 79200073
Intestinal stenosis 10.84 9.75 52 535956 3702 79204678
Sinus congestion 10.81 9.75 191 535817 19705 79188675
Steroid diabetes 10.81 9.75 5 536003 3501 79204879
Gait inability 10.80 9.75 492 535516 58425 79149955
Skin laceration 10.80 9.75 263 535745 28699 79179681
Photophobia 10.78 9.75 196 535812 20332 79188048
Extradural haematoma 10.74 9.75 3 536005 2873 79205507
Hepatitis E antibody positive 10.70 9.75 11 535997 257 79208123
Mycobacterium tuberculosis complex test positive 10.60 9.75 42 535966 2750 79205630
Epilepsy 10.59 9.75 202 535806 40658 79167722
Colitis microscopic 10.55 9.75 37 535971 10731 79197649
Nephrotic syndrome 10.55 9.75 39 535969 11135 79197245
Vascular rupture 10.55 9.75 30 535978 1655 79206725
Vacuum extractor delivery 10.53 9.75 8 536000 123 79208257
Amyloid arthropathy 10.49 9.75 16 535992 564 79207816
Labyrinthitis 10.45 9.75 43 535965 2865 79205515
Skin injury 10.43 9.75 48 535960 3358 79205022
Retinal haemorrhage 10.42 9.75 25 535983 8192 79200188
Ventricular hypokinesia 10.41 9.75 30 535978 9249 79199131
Hyperhomocysteinaemia 10.41 9.75 15 535993 502 79207878
Atrial flutter 10.38 9.75 94 535914 21531 79186849
Vein disorder 10.38 9.75 65 535943 5117 79203263
Injection site discolouration 10.34 9.75 87 535921 7527 79200853
Investigation abnormal 10.33 9.75 34 535974 2032 79206348
Eyelid oedema 10.33 9.75 52 535956 13635 79194745
Lip and/or oral cavity cancer 10.31 9.75 23 535985 1090 79207290
Precancerous skin lesion 10.31 9.75 26 535982 1335 79207045
Dyspnoea exertional 10.30 9.75 479 535529 86594 79121786
Osteonecrosis 10.28 9.75 147 535861 30948 79177432
Peritoneal dialysis complication 10.25 9.75 37 535971 2317 79206063
Neutropenic colitis 10.25 9.75 14 535994 5693 79202687
Abortion missed 10.23 9.75 25 535983 1258 79207122
Euglycaemic diabetic ketoacidosis 10.20 9.75 19 535989 6825 79201555
Ventricular extrasystoles 10.20 9.75 84 535924 19620 79188760
Cogwheel rigidity 10.17 9.75 4 536004 3084 79205296
Chest pain 10.15 9.75 1705 534303 280599 78927781
Abdominal distension 10.15 9.75 680 535328 118970 79089410
Skin graft failure 10.14 9.75 10 535998 222 79208158
Seronegative arthritis 10.13 9.75 60 535948 4632 79203748
Prescribed underdose 10.11 9.75 265 535743 29249 79179131
Laryngeal oedema 10.09 9.75 25 535983 8104 79200276
Dermatitis exfoliative 10.09 9.75 38 535970 10791 79197589
Renal cancer 10.08 9.75 45 535963 12181 79196199
Onychomadesis 10.04 9.75 65 535943 5177 79203203
Swollen joint count 10.04 9.75 24 535984 1191 79207189
Lung opacity 10.01 9.75 12 535996 5162 79203218
Excessive cerumen production 9.95 9.75 18 535990 732 79207648
Sensitivity to weather change 9.92 9.75 90 535918 7957 79200423
Pancreatic steatosis 9.88 9.75 23 535985 1122 79207258
Tumour haemorrhage 9.87 9.75 8 536000 4136 79204244
Vaginal abscess 9.87 9.75 13 535995 399 79207981
Infected bite 9.87 9.75 32 535976 1898 79206482
Electrolyte imbalance 9.85 9.75 147 535861 30734 79177646
Product monitoring error 9.85 9.75 29 535979 8877 79199503
Anal skin tags 9.84 9.75 14 535994 463 79207917
Hernia pain 9.80 9.75 14 535994 465 79207915
Stress at work 9.80 9.75 23 535985 1128 79207252
Nail pitting 9.77 9.75 13 535995 403 79207977
Hepatitis E virus test positive 9.77 9.75 11 535997 286 79208094
Autonomic nervous system imbalance 9.77 9.75 10 535998 4620 79203760
Joint space narrowing 9.76 9.75 17 535991 671 79207709

FDA Adverse Event Reporting System (Pediatric)

None

Pharmacologic Action:

SourceCodeDescription
CHEBI has role CHEBI:50733 Dietary Supplement

Drug Use | Suggest Off label Use Form| |View source of the data|

None




🐶 Veterinary Drug Use

None

🐶 Veterinary products

None

Acid dissociation constants calculated using MoKa v3.0.0

None

Orange Book patent data (new drug applications)

None

Orange Book exclusivity data (new drug applications)

Formulation strengthTrade nameApplicantApplication numberApproval dateTypeDose formRouteExclusivity dateDescription
EQ 0.3MG COPPER/ML;EQ 55MCG BASE/ML;EQ 60MCG SELENIUM/ML;EQ 3MG BASE/ML (1ML) TRALEMENT AM REGENT N209376 July 2, 2020 RX SOLUTION INTRAVENOUS April 30, 2024 NEW CHEMICAL ENTITY
EQ 0.3MG COPPER/ML;EQ 55MCG BASE/ML;EQ 60MCG SELENIUM/ML;EQ 3MG BASE/ML (5ML) TRALEMENT AM REGENT N209376 Dec. 2, 2020 RX SOLUTION INTRAVENOUS April 30, 2024 NEW CHEMICAL ENTITY
EQ 60MCG COPPER/ML;EQ 3MCG BASE/ML;EQ 6MCG SELENIUM/ML;EQ 1000MCG BASE/ML (1ML) MULTRYS AM REGENT N209376 June 30, 2021 RX SOLUTION INTRAVENOUS April 30, 2024 NEW CHEMICAL ENTITY

Bioactivity Summary:

None

External reference:

IDSource
D04854 KEGG_DRUG
4017709 VUID
N0000179176 NUI
4017681 VANDF
4017709 VANDF
CHEBI:86364 CHEBI
CHEMBL1200557 ChEMBL_ID
CHEMBL2103742 ChEMBL_ID
C039798 MESH_SUPPLEMENTAL_RECORD_UI
W00LYS4T26 UNII
29268 RXNORM
1544 MMSL
33690 MMSL
5021 MMSL
d00434 MMSL
000858 NDDF
C0065649 UMLSCUI
10034-96-5 SECONDARY_CAS_RN

Pharmaceutical products:

ProductCategoryIngredientsNDCFormQuantityRouteMarketingLabel
Multitrace-4 Neonatal HUMAN PRESCRIPTION DRUG LABEL 4 0517-6202 INJECTION, SOLUTION 77 mg INTRAVENOUS UNAPPROVED DRUG OTHER 14 sections
Manganese Sulfate HUMAN PRESCRIPTION DRUG LABEL 1 0517-6410 INJECTION, SOLUTION 0.10 mg INTRAVENOUS UNAPPROVED DRUG OTHER 13 sections
Multitrace-5 HUMAN PRESCRIPTION DRUG LABEL 5 0517-8201 INJECTION, SOLUTION, CONCENTRATE 1.54 mg INTRAVENOUS UNAPPROVED DRUG OTHER 14 sections
Multitrace-5 HUMAN PRESCRIPTION DRUG LABEL 5 0517-8210 INJECTION, SOLUTION, CONCENTRATE 1.54 mg INTRAVENOUS UNAPPROVED DRUG OTHER 14 sections
Multitrace-5 HUMAN PRESCRIPTION DRUG LABEL 5 0517-8510 INJECTION, SOLUTION 0.31 mg INTRAVENOUS UNAPPROVED DRUG OTHER 14 sections
Multitrace -4 Pediatric HUMAN PRESCRIPTION DRUG LABEL 4 0517-9203 INJECTION, SOLUTION, CONCENTRATE 77 ug INTRAVENOUS UNAPPROVED DRUG OTHER 14 sections
Multrys HUMAN PRESCRIPTION DRUG LABEL 4 0517-9302 INJECTION, SOLUTION 8.22 ug INTRAVENOUS NDA 19 sections
Tralement HUMAN PRESCRIPTION DRUG LABEL 4 0517-9305 INJECTION, SOLUTION 55 ug INTRAVENOUS NDA 22 sections
Trace Elements 4 HUMAN PRESCRIPTION DRUG LABEL 4 0517-9310 INJECTION, SOLUTION 92.30 ug INTRAVENOUS UNAPPROVED DRUG OTHER 14 sections
Se-Tan PLUS HUMAN PRESCRIPTION DRUG LABEL 13 13925-118 CAPSULE, GELATIN COATED 1.30 mg ORAL unapproved drug other 19 sections
Se-Tan PLUS HUMAN PRESCRIPTION DRUG LABEL 13 13925-118 CAPSULE, GELATIN COATED 1.30 mg ORAL unapproved drug other 19 sections
Centratex HUMAN PRESCRIPTION DRUG LABEL 13 23359-100 CAPSULE 1.30 mg ORAL unapproved drug other 13 sections
Concept OB HUMAN PRESCRIPTION DRUG LABEL 15 52747-620 CAPSULE 1.30 mg ORAL unapproved drug other 13 sections
Concept OB HUMAN PRESCRIPTION DRUG LABEL 15 52747-620 CAPSULE 1.30 mg ORAL unapproved drug other 13 sections
PureVit DualFe Plus HUMAN PRESCRIPTION DRUG LABEL 13 59088-112 CAPSULE 1.30 mg ORAL unapproved drug other 12 sections
PureVit DualFe Plus HUMAN PRESCRIPTION DRUG LABEL 13 59088-112 CAPSULE 1.30 mg ORAL unapproved drug other 12 sections
Vitrexyl HUMAN PRESCRIPTION DRUG LABEL 17 59088-164 TABLET 2.30 mg ORAL unapproved drug other 11 sections
Vitrexyl HUMAN PRESCRIPTION DRUG LABEL 17 59088-164 TABLET 2.30 mg ORAL unapproved drug other 11 sections
Vitrexyl plus Iron HUMAN PRESCRIPTION DRUG LABEL 18 59088-165 TABLET 2.30 mg ORAL unapproved drug other 13 sections
Vitrexyl plus Iron HUMAN PRESCRIPTION DRUG LABEL 18 59088-165 TABLET 2.30 mg ORAL unapproved drug other 13 sections
Prenatrix HUMAN PRESCRIPTION DRUG LABEL 20 59088-166 TABLET 2.60 mg ORAL unapproved drug other 13 sections
Prenatrix HUMAN PRESCRIPTION DRUG LABEL 20 59088-166 TABLET 2.60 mg ORAL unapproved drug other 13 sections
Vitrexate HUMAN PRESCRIPTION DRUG LABEL 17 59088-167 TABLET 2.30 mg ORAL unapproved drug other 11 sections
Vitrexate HUMAN PRESCRIPTION DRUG LABEL 17 59088-167 TABLET 2.30 mg ORAL unapproved drug other 11 sections
Vitrexate FE HUMAN PRESCRIPTION DRUG LABEL 18 59088-168 TABLET 2.30 mg ORAL unapproved drug other 13 sections
Vitrexate FE HUMAN PRESCRIPTION DRUG LABEL 18 59088-168 TABLET 2.30 mg ORAL unapproved drug other 13 sections
Prenatryl HUMAN PRESCRIPTION DRUG LABEL 20 59088-169 TABLET 2.60 mg ORAL unapproved drug other 13 sections
Prenatryl HUMAN PRESCRIPTION DRUG LABEL 20 59088-169 TABLET 2.60 mg ORAL unapproved drug other 13 sections
Vitranol HUMAN PRESCRIPTION DRUG LABEL 17 59088-171 TABLET 2.30 mg ORAL unapproved drug other 11 sections
Vitranol HUMAN PRESCRIPTION DRUG LABEL 17 59088-171 TABLET 2.30 mg ORAL unapproved drug other 11 sections