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| Stem definition | Drug id | CAS RN |
|---|---|---|
| antibiotics, 6-aminopenicillanic acid derivatives | 4459 | 54-35-3 |
| Molecule | Description |
|---|---|
|
Synonyms:
|
Semisynthetic antibiotic prepared by combining penicillin G with PROCAINE.
|
| Dose | Unit | Route |
|---|---|---|
| 0.60 | g | P |
| Property | Value | Reference |
|---|---|---|
| BA (Bioavailability) | 25 % |
None
| Date | Agency | Company | Orphan |
|---|---|---|---|
| April 26, 1948 | FDA | KING PHARMS |
| MedDRA adverse event term | Likelihood ratio | Likelihood ratio threshold | Patients taking drug having adverse event | Patients taking drug not having adverse event | Patients not taking drug having adverse event | Patients not taking drug not having adverse event |
|---|---|---|---|---|---|---|
| Drug hypersensitivity | 195.21 | 104.74 | 48 | 37 | 463561 | 90164801 |
None
| MedDRA adverse event term | Likelihood ratio | Likelihood ratio threshold | Patients taking drug having adverse event | Patients taking drug not having adverse event | Patients not taking drug having adverse event | Patients not taking drug not having adverse event |
|---|---|---|---|---|---|---|
| Drug hypersensitivity | 176.11 | 81.59 | 49 | 98 | 454041 | 110135111 |
None
| Source | Code | Description |
|---|---|---|
| ATC | J01CE09 | ANTIINFECTIVES FOR SYSTEMIC USE ANTIBACTERIALS FOR SYSTEMIC USE BETA-LACTAM ANTIBACTERIALS, PENICILLINS Beta-lactamase sensitive penicillins |
| MeSH PA | D000890 | Anti-Infective Agents |
| MeSH PA | D000900 | Anti-Bacterial Agents |
| CHEBI has role | CHEBI:33282 | antibacterial agent |
| CHEBI has role | CHEBI:35554 | cardiovascular drug |
| CHEBI has role | CHEBI:36047 | antibacterial drug |
| CHEBI has role | CHEBI:53000 | epitope |
| CHEBI has role | CHEBI:66981 | ophthalmology drug |
| CHEBI has role | CHEBI:88188 | drug allergen |
| CHEBI has role | CHEBI:35441 | antiinfective agent |
| Disease | Relation | SNOMED_ID | DOID |
|---|---|---|---|
| Rat bite fever | indication | 1685005 | |
| Acute otitis media | indication | 3110003 | |
| Infection of skin AND/OR subcutaneous tissue | indication | 19824006 | |
| Gingivostomatitis | indication | 20607006 | |
| Pinta | indication | 22064009 | DOID:1022 |
| Neurosyphilis | indication | 26039008 | DOID:9988 |
| Scarlet fever | indication | 30242009 | DOID:8596 |
| Pneumonia due to Streptococcus | indication | 34020007 | |
| Congenital syphilis | indication | 35742006 | DOID:9856 |
| Streptococcal tonsillitis | indication | 41582007 | |
| Erysipelas | indication | 44653001 | DOID:11330 |
| Yaws | indication | 70647001 | DOID:10371 |
| Late syphilis | indication | 72083004 | DOID:8200 |
| Syphilis | indication | 76272004 | |
| Streptococcal infectious disease | indication | 85769006 | |
| Primary genital syphilis | indication | 186847001 | |
| Pneumococcal pneumonia | indication | 233607000 | |
| Secondary syphilis | indication | 240557004 | DOID:4157 |
| Bejel | indication | 240686008 | DOID:13431 |
| Bacterial endocarditis | indication | 301183007 | |
| Streptococcus pyogenes infection | indication | 302809008 | |
| Diphtheria | indication | 397428000 | |
| Fusospirochetal pharyngitis | indication | 399095008 | |
| Erysipeloid | indication | 400105005 | |
| Pharyngitis | indication | 405737000 | DOID:2275 |
| Infection due to Staphylococcus aureus | indication | 406602003 | |
| Anthrax | indication | 409498004 | DOID:7427 |
| Latent syphilis | indication | 444150000 | DOID:9531 |
| Asymptomatic Congenital Syphilis | indication | ||
| Upper Respiratory Pneumococcal Infection | indication | ||
| Streptococcal Endocarditis | indication | ||
| Pneumococcal Acute Otitis Media | indication | ||
| Kidney disease | contraindication | 90708001 | DOID:557 |
| Infectious mononucleosis | contraindication | 271558008 | DOID:8568 |
| Pseudomembranous enterocolitis | contraindication | 397683000 |
| Species | Use | Relation |
|---|---|---|
| Dogs | Bacterial infections | Indication |
| Cats | Bacterial infections | Indication |
| Cattle | Mastitis caused by Staphylococcus aureus | Indication |
| Cattle | Mastitis caused by Streptococcus agalactiae | Indication |
| Cattle | Mastitis caused by Streptococcus dysgalactiae | Indication |
| Cattle | Mastitis caused by Streptococcus uberis | Indication |
| Cattle | Intramammary use to reduce the frequency of existing infection and to prevent new infections with Staphylococcus aureus | Indication |
| Cattle | Bacterial pneumonia caused by Pasteurella multocida | Indication |
| Cattle | Bacterial infections | Indication |
| Horses | Strangles caused by Streptococcus equi | Indication |
| Horses | Bacterial infections | Indication |
| Sheep | Bacterial pneumonia caused by Pasteurella multocida | Indication |
| Swine | Erysipelas caused by Erysipelothrix rhusiopathiae | Indication |
| Product | Applicant | Ingredients |
|---|---|---|
| Quartermaster Suspension | HQ Specialty Pharma Corp. | 2 |
| Albacillin Suspension, Special Formula 17900-Forte Suspension | Zoetis Inc. | 2 |
| Dry-Mast | HQ Specialty Pharma Corp. | 2 |
| Albadry Plus Suspension | Zoetis Inc. | 2 |
| Norocillin | Norbrook Laboratories, Ltd. | 1 |
| Go-Dry, Masti-Clear | HQ Specialty Pharma Corp. | 1 |
| Longicil Fortified | Zoetis Inc. | 2 |
| PEN-G-MAX | Huvepharma EOOD | 1 |
| Forte Topical Ointment | Zoetis Inc. | 4 |
| Crystalline Pro Penicillin G | Zoetis Inc. | 1 |
| Dura-biotic, Flo-cillin | Zoetis Inc. | 2 |
| Crysticillin | Zoetis Inc. | 1 |
| Formula A-34, Uni Biotic 4 Dose | Bimeda Animal Health Limited | 1 |
| Dual-Cillin, Pen BP-48 | Huvepharma EOOD | 2 |
| Pro-Pen-G | Bimeda Animal Health Limited | 1 |
| Combi-PEN-48 | Bimeda Animal Health Limited | 2 |
None
None
None
None
| ID | Source |
|---|---|
| D02461 | KEGG_DRUG |
| 4017437 | VUID |
| N0000145825 | NUI |
| 6130-64-9 | SECONDARY_CAS_RN |
| 4017437 | VANDF |
| 4017440 | VANDF |
| CHEBI:749925 | CHEBI |
| CHEMBL1628385 | ChEMBL_ID |
| CHEMBL1200936 | ChEMBL_ID |
| DB09320 | DRUGBANK_ID |
| 5903 | PUBCHEM_CID |
| 7980 | RXNORM |
| 160608 | MMSL |
| 45788 | MMSL |
| 5246 | MMSL |
| d07390 | MMSL |
| 002681 | NDDF |
| 004977 | NDDF |
| 323389000 | SNOMEDCT_US |
| 387246005 | SNOMEDCT_US |
| 449005 | SNOMEDCT_US |
| 78507004 | SNOMEDCT_US |
| C0030830 | UMLSCUI |
| D010402 | MESH_DESCRIPTOR_UI |
| C0030827 | UMLSCUI |
| DB01053 | DRUGBANK_ID |
| 5904 | PUBCHEM_CID |
| 17R794ESYN | UNII |
| CHEBI:18208 | CHEBI |
| Product | Category | Ingredients | NDC | Form | Quantity | Route | Marketing | Label |
|---|---|---|---|---|---|---|---|---|
| BICILLIN CR | HUMAN PRESCRIPTION DRUG LABEL | 2 | 50090-1815 | INJECTION, SUSPENSION | 600000 [iU] | INTRAMUSCULAR | NDA | 24 sections |
| BICILLIN CR | HUMAN PRESCRIPTION DRUG LABEL | 2 | 54868-5932 | INJECTION, SUSPENSION | 600000 [iU] | INTRAMUSCULAR | NDA | 22 sections |
| BICILLIN CR | HUMAN PRESCRIPTION DRUG LABEL | 2 | 60793-600 | INJECTION, SUSPENSION | 600000 [iU] | INTRAMUSCULAR | NDA | 26 sections |
| BICILLIN CR | HUMAN PRESCRIPTION DRUG LABEL | 2 | 60793-601 | INJECTION, SUSPENSION | 600000 [iU] | INTRAMUSCULAR | NDA | 26 sections |
| BICILLIN C-R 900/300 | HUMAN PRESCRIPTION DRUG LABEL | 2 | 60793-602 | INJECTION, SUSPENSION | 300000 [iU] | INTRAMUSCULAR | NDA | 26 sections |
| BICILLIN CR | HUMAN PRESCRIPTION DRUG LABEL | 2 | 68258-8910 | INJECTION, SUSPENSION | 600000 [iU] | INTRAMUSCULAR | NDA | 24 sections |