sulfisoxazole acetyl 🐶 Veterinary Use | Indications/Contra | FAERs-F | FAERs-M | Orange Bk | BioActivity |
| Stem definition | Drug id | CAS RN |
|---|---|---|
| 4458 | 80-74-0 |
Description:
| Molecule | Description |
|---|---|
|
Synonyms:
|
Legend: OFP - off patent OFM - off market ONP - on patent |
Drug dosage:
None
ADMET properties:
| Property | Value | Reference |
|---|---|---|
| fu (Fraction unbound in plasma) | 0 % | Kawashima H, Watanabe R, Esaki T, Kuroda M, Nagao C, Natsume-Kitatani Y, Ohashi R, Komura H, Mizuguchi K |
Approvals:
| Date | Agency | Company | Orphan |
|---|---|---|---|
| Dec. 4, 1953 | FDA | ROCHE |
FDA Adverse Event Reporting System (Female)
None
FDA Adverse Event Reporting System (Male)
None
FDA Adverse Event Reporting System (Geriatric)
None
FDA Adverse Event Reporting System (Pediatric)
None
Pharmacologic Action:
| Source | Code | Description |
|---|---|---|
| MeSH PA | D000890 | Anti-Infective Agents |
Drug Use | Suggest Off label Use Form| |View source of the data|
None
🐶 Veterinary Drug Use
None
🐶 Veterinary products
None
Acid dissociation constants calculated using MoKa v3.0.0
| Dissociation level | Dissociation constant | Type (acidic/basic) |
|---|---|---|
| pKa1 | 1.49 | Basic |
Orange Book patent data (new drug applications)
None
Orange Book exclusivity data (new drug applications)
None
Bioactivity Summary:
| Target | Class | Pharos | UniProt | Action | Type | Activity value (-log[M]) | Mechanism action | Bioact source | MoA source |
|---|---|---|---|---|---|---|---|---|---|
| Endothelin-1 receptor | GPCR | IC50 | 6.11 | CHEMBL | |||||
| Endothelin B receptor | GPCR | IC50 | 4.62 | CHEMBL | |||||
| Dihydropteroate synthase | Enzyme | INHIBITOR | CHEMBL | CHEMBL | |||||
| Endothelin-1 receptor | GPCR | IC50 | 6.11 | CHEMBL |
External reference:
| ID | Source |
|---|---|
| D05956 | KEGG_DRUG |
| 4017766 | VUID |
| N0000179292 | NUI |
| 4017766 | VANDF |
| CHEBI:135975 | CHEBI |
| CHEMBL1200910 | ChEMBL_ID |
| DB14033 | DRUGBANK_ID |
| C005387 | MESH_SUPPLEMENTAL_RECORD_UI |
| WBT5QH3KED | UNII |
| 6662 | PUBCHEM_CID |
| 224975 | RXNORM |
| 3965 | MMSL |
| 499 | MMSL |
| 5532 | MMSL |
| 002819 | NDDF |
| 88757004 | SNOMEDCT_US |
| C0081437 | UMLSCUI |
| D013444 | MESH_DESCRIPTOR_UI |
| CHEMBL453 | ChEMBL_ID |
| CHEMBL1200321 | ChEMBL_ID |
Pharmaceutical products:
| Product | Category | Ingredients | NDC | Form | Quantity | Route | Marketing | Label |
|---|---|---|---|---|---|---|---|---|
| ERYTHROMYCIN ETHYLSUCCINATE AND SULFISOXAZOLE ACETYL | HUMAN PRESCRIPTION DRUG LABEL | 2 | 21695-690 | GRANULE, FOR SUSPENSION | 600 mg | ORAL | ANDA | 26 sections |
| ERYTHROMYCIN ETHYLSUCCINATE AND SULFISOXAZOLE ACETYL | HUMAN PRESCRIPTION DRUG LABEL | 2 | 54868-0971 | GRANULE, FOR SUSPENSION | 600 mg | ORAL | ANDA | 26 sections |