sulfisoxazole acetyl Indications/Contra | FAERs-F | FAERs-M | Orange Bk | BioActivity |

Stem definitionDrug idCAS RN
4458 80-74-0

Description:

MoleculeDescription

Molfile Inchi Smiles

Synonyms:

  • sulfisoxazole acetyl
  • acetylsulfisoxazole
  • gantrisin
  • Molecular weight: 309.34
  • Formula: C13H15N3O4S
  • CLOGP: 1.03
  • LIPINSKI: 0
  • HAC: 7
  • HDO: 1
  • TPSA: 106.50
  • ALOGS: -3.36
  • ROTB: 2

  • Status: OFM

  • Legend:
    OFP - off patent
    OFM - off market
    ONP - on patent

Drug dosage:

None

ADMET properties:

None

Approvals:

DateAgencyCompanyOrphan
Dec. 4, 1953 FDA ROCHE

FDA Adverse Event Reporting System (Female)

None

FDA Adverse Event Reporting System (Male)

None

Pharmacologic Action:

SourceCodeDescription
MeSH PA D000890 Anti-Infective Agents

Drug Use (View source of the data)

None

Acid dissociation constants calculated using MoKa v3.0.0

Dissociation levelDissociation constantType (acidic/basic)
pKa1 1.49 Basic

Orange Book patent data (new drug applications)

None

Orange Book exclusivity data (new drug applications)

None

Bioactivity Summary:

TargetClassPharosUniProtActionTypeActivity value
(-log[M])
Mechanism
action
Bioact sourceMoA source
Endothelin-1 receptor GPCR IC50 6.11 CHEMBL
Endothelin B receptor GPCR IC50 4.62 CHEMBL
Dihydropteroate synthase Enzyme INHIBITOR CHEMBL CHEMBL
Endothelin-1 receptor GPCR IC50 6.11 CHEMBL

External reference:

IDSource
D05956 KEGG_DRUG
4017766 VUID
N0000179292 NUI
4017766 VANDF
CHEBI:135975 CHEBI
CHEMBL1200910 ChEMBL_ID
CHEMBL453 ChEMBL_ID
CHEMBL1200321 ChEMBL_ID
DB14033 DRUGBANK_ID
C005387 MESH_SUPPLEMENTAL_RECORD_UI
WBT5QH3KED UNII
6662 PUBCHEM_CID
224975 RXNORM
3965 MMSL
499 MMSL
5532 MMSL
002819 NDDF
88757004 SNOMEDCT_US
D013444 MESH_DESCRIPTOR_UI
C0081437 UMLSCUI

Pharmaceutical products:

ProductCategoryIngredientsNDCFormQuantityRouteMarketingLabel
ERYTHROMYCIN ETHYLSUCCINATE AND SULFISOXAZOLE ACETYL HUMAN PRESCRIPTION DRUG LABEL 2 21695-690 GRANULE, FOR SUSPENSION 600 mg ORAL ANDA 26 sections
ERYTHROMYCIN ETHYLSUCCINATE AND SULFISOXAZOLE ACETYL HUMAN PRESCRIPTION DRUG LABEL 2 54868-0971 GRANULE, FOR SUSPENSION 600 mg ORAL ANDA 26 sections