Stem definition | Drug id | CAS RN |
---|---|---|
corticosteroids, except prednisolone derivatives | 4456 | 125-04-2 |
None
Property | Value | Reference |
---|---|---|
S (Water solubility) | 0.23 mg/mL | Bocci G, Oprea TI, Benet LZ |
Date | Agency | Company | Orphan |
---|---|---|---|
April 27, 1955 | FDA | PHARMACIA AND UPJOHN |
MedDRA adverse event term | Likelihood ratio | Likelihood ratio threshold | Patients taking drug having adverse event | Patients taking drug not having adverse event | Patients not taking drug having adverse event | Patients not taking drug not having adverse event |
---|---|---|---|---|---|---|
Infusion related reaction | 253.95 | 13.56 | 351 | 20028 | 245170 | 63223473 |
Flushing | 85.89 | 13.56 | 113 | 20266 | 74974 | 63393669 |
Urticaria | 65.25 | 13.56 | 156 | 20223 | 165646 | 63302997 |
Toxicity to various agents | 60.68 | 13.56 | 5 | 20374 | 247245 | 63221398 |
Intentional product use issue | 44.65 | 13.56 | 115 | 20264 | 127777 | 63340866 |
Drug ineffective | 41.48 | 13.56 | 184 | 20195 | 1044581 | 62424062 |
Blood pressure fluctuation | 38.63 | 13.56 | 60 | 20319 | 46257 | 63422386 |
Off label use | 37.54 | 13.56 | 355 | 20024 | 674107 | 62794536 |
Drug interaction | 36.41 | 13.56 | 14 | 20365 | 229117 | 63239526 |
Febrile neutropenia | 35.80 | 13.56 | 101 | 20278 | 118348 | 63350295 |
Swollen joint count increased | 34.78 | 13.56 | 50 | 20329 | 36004 | 63432639 |
Chest discomfort | 34.44 | 13.56 | 95 | 20284 | 109874 | 63358769 |
Disseminated intravascular coagulation | 33.96 | 13.56 | 36 | 20343 | 19015 | 63449628 |
Rheumatic fever | 32.05 | 13.56 | 53 | 20326 | 43058 | 63425585 |
Blood pressure decreased | 30.91 | 13.56 | 66 | 20313 | 64956 | 63403687 |
Sciatica | 30.79 | 13.56 | 46 | 20333 | 34278 | 63434365 |
Deep vein thrombosis postoperative | 30.70 | 13.56 | 27 | 20352 | 11342 | 63457301 |
Pyrexia | 26.77 | 13.56 | 249 | 20130 | 470229 | 62998414 |
Oxygen saturation decreased | 24.31 | 13.56 | 73 | 20306 | 88512 | 63380131 |
External ear cellulitis | 23.34 | 13.56 | 7 | 20372 | 283 | 63468360 |
Anaphylactic shock | 23.12 | 13.56 | 33 | 20346 | 23600 | 63445043 |
Autoimmune disorder | 23.03 | 13.56 | 28 | 20351 | 17149 | 63451494 |
Adrenocortical insufficiency acute | 22.60 | 13.56 | 11 | 20368 | 1687 | 63466956 |
Pruritus | 21.90 | 13.56 | 194 | 20185 | 361259 | 63107384 |
Throat tightness | 21.82 | 13.56 | 33 | 20346 | 24854 | 63443789 |
Inappropriate schedule of product administration | 21.64 | 13.56 | 78 | 20301 | 103887 | 63364756 |
Cytomegalovirus infection | 21.60 | 13.56 | 30 | 20349 | 20922 | 63447721 |
Poor venous access | 21.30 | 13.56 | 25 | 20354 | 14760 | 63453883 |
Endometritis decidual | 20.86 | 13.56 | 4 | 20375 | 21 | 63468622 |
Type 2 diabetes mellitus | 20.81 | 13.56 | 56 | 20323 | 63812 | 63404831 |
Road traffic accident | 20.75 | 13.56 | 40 | 20339 | 36592 | 63432051 |
Colitis ulcerative | 20.64 | 13.56 | 33 | 20346 | 26058 | 63442585 |
Helicobacter infection | 20.51 | 13.56 | 71 | 20308 | 92714 | 63375929 |
Injection site pain | 20.49 | 13.56 | 8 | 20371 | 129792 | 63338851 |
Shock | 20.41 | 13.56 | 31 | 20348 | 23432 | 63445211 |
Septic shock | 20.29 | 13.56 | 57 | 20322 | 66572 | 63402071 |
Vascular rupture | 19.63 | 13.56 | 10 | 20369 | 1690 | 63466953 |
Duodenal ulcer perforation | 19.50 | 13.56 | 67 | 20312 | 87142 | 63381501 |
Feeling hot | 19.36 | 13.56 | 47 | 20332 | 50307 | 63418336 |
Death | 19.29 | 13.56 | 59 | 20320 | 374322 | 63094321 |
Erythema | 19.27 | 13.56 | 109 | 20270 | 175642 | 63293001 |
Abdominal pain | 19.07 | 13.56 | 160 | 20219 | 293296 | 63175347 |
Throat irritation | 18.80 | 13.56 | 39 | 20340 | 37608 | 63431035 |
Genital rash | 18.77 | 13.56 | 7 | 20372 | 557 | 63468086 |
Cytomegalovirus viraemia | 18.51 | 13.56 | 15 | 20364 | 5634 | 63463009 |
Bronchospasm | 18.20 | 13.56 | 25 | 20354 | 17255 | 63451388 |
Product use issue | 18.10 | 13.56 | 127 | 20252 | 220393 | 63248250 |
Lupus vulgaris | 17.73 | 13.56 | 15 | 20364 | 5979 | 63462664 |
Intestinal resection | 17.28 | 13.56 | 11 | 20368 | 2837 | 63465806 |
Wheezing | 16.83 | 13.56 | 68 | 20311 | 95527 | 63373116 |
Tracheal inflammation | 16.81 | 13.56 | 4 | 20375 | 65 | 63468578 |
Fall | 16.74 | 13.56 | 67 | 20312 | 392267 | 63076376 |
Apocrine miliaria | 16.74 | 13.56 | 3 | 20376 | 10 | 63468633 |
Facet joint syndrome | 16.62 | 13.56 | 20 | 20359 | 12118 | 63456525 |
Dislocation of vertebra | 16.61 | 13.56 | 17 | 20362 | 8618 | 63460025 |
Epiglottitis | 16.57 | 13.56 | 6 | 20373 | 439 | 63468204 |
Heart rate increased | 16.56 | 13.56 | 67 | 20312 | 94171 | 63374472 |
Blood pressure increased | 16.14 | 13.56 | 98 | 20281 | 161964 | 63306679 |
Lower limb fracture | 15.66 | 13.56 | 28 | 20351 | 24193 | 63444450 |
Rheumatoid arthritis | 15.32 | 13.56 | 37 | 20342 | 253782 | 63214861 |
Oropharyngeal discomfort | 15.23 | 13.56 | 13 | 20366 | 5247 | 63463396 |
Hypoaesthesia | 15.01 | 13.56 | 99 | 20280 | 168294 | 63300349 |
Oedema | 14.53 | 13.56 | 66 | 20313 | 97556 | 63371087 |
Liver disorder | 14.50 | 13.56 | 44 | 20335 | 53643 | 63415000 |
Pharyngitis | 13.95 | 13.56 | 24 | 20355 | 20119 | 63448524 |
Crohn's disease | 13.93 | 13.56 | 12 | 20367 | 4901 | 63463742 |
X-ray abnormal | 13.88 | 13.56 | 15 | 20364 | 8095 | 63460548 |
Hypofibrinogenaemia | 13.85 | 13.56 | 7 | 20372 | 1163 | 63467480 |
Gastroenteritis | 13.81 | 13.56 | 28 | 20351 | 26562 | 63442081 |
Psoriatic arthropathy | 13.71 | 13.56 | 62 | 20317 | 91458 | 63377185 |
Limb mass | 13.70 | 13.56 | 10 | 20369 | 3222 | 63465421 |
MedDRA adverse event term | Likelihood ratio | Likelihood ratio threshold | Patients taking drug having adverse event | Patients taking drug not having adverse event | Patients not taking drug having adverse event | Patients not taking drug not having adverse event |
---|---|---|---|---|---|---|
Infusion related reaction | 308.22 | 15.12 | 203 | 11661 | 52854 | 34892213 |
Nipple swelling | 78.84 | 15.12 | 19 | 11845 | 308 | 34944759 |
Nipple pain | 63.16 | 15.12 | 20 | 11844 | 917 | 34944150 |
Disseminated intravascular coagulation | 56.85 | 15.12 | 52 | 11812 | 21764 | 34923303 |
Pyrexia | 54.45 | 15.12 | 240 | 11624 | 332773 | 34612294 |
Flushing | 52.88 | 15.12 | 60 | 11804 | 32360 | 34912707 |
Off label use | 47.82 | 15.12 | 273 | 11591 | 419251 | 34525816 |
Febrile neutropenia | 41.54 | 15.12 | 121 | 11743 | 136728 | 34808339 |
Platelet count decreased | 35.50 | 15.12 | 105 | 11759 | 119612 | 34825455 |
Urticaria | 32.61 | 15.12 | 68 | 11796 | 62309 | 34882758 |
Anaphylactic reaction | 32.43 | 15.12 | 47 | 11817 | 32254 | 34912813 |
Blood iron decreased | 32.37 | 15.12 | 21 | 11843 | 5292 | 34939775 |
Frequent bowel movements | 32.37 | 15.12 | 30 | 11834 | 12757 | 34932310 |
Chills | 30.92 | 15.12 | 78 | 11786 | 80965 | 34864102 |
Product use issue | 30.84 | 15.12 | 67 | 11797 | 63149 | 34881918 |
Toxicity to various agents | 30.45 | 15.12 | 15 | 11849 | 200347 | 34744720 |
Blood pressure decreased | 30.32 | 15.12 | 59 | 11805 | 51456 | 34893611 |
Blood pressure fluctuation | 30.24 | 15.12 | 40 | 11824 | 25209 | 34919858 |
Cytomegalovirus infection | 29.16 | 15.12 | 40 | 11824 | 26095 | 34918972 |
Neutrophil count decreased | 27.05 | 15.12 | 56 | 11808 | 51048 | 34894019 |
Anaphylactic shock | 25.13 | 15.12 | 29 | 11835 | 15912 | 34929155 |
Posthaemorrhagic hydrocephalus | 23.71 | 15.12 | 6 | 11858 | 120 | 34944947 |
Therapeutic product effect prolonged | 23.68 | 15.12 | 7 | 11857 | 254 | 34944813 |
Acute graft versus host disease in skin | 23.28 | 15.12 | 17 | 11847 | 5184 | 34939883 |
Large intestine polyp | 22.85 | 15.12 | 20 | 11844 | 7894 | 34937173 |
Drug interaction | 22.67 | 15.12 | 26 | 11838 | 225920 | 34719147 |
Death | 22.02 | 15.12 | 66 | 11798 | 397983 | 34547084 |
Heart rate irregular | 22.02 | 15.12 | 27 | 11837 | 15780 | 34929287 |
Antithrombin III decreased | 21.98 | 15.12 | 7 | 11857 | 327 | 34944740 |
Septic shock | 21.25 | 15.12 | 63 | 11801 | 71771 | 34873296 |
Pallor | 21.22 | 15.12 | 34 | 11830 | 25446 | 34919621 |
Erythema | 20.93 | 15.12 | 72 | 11792 | 88708 | 34856359 |
Epstein-Barr virus associated lymphoproliferative disorder | 20.51 | 15.12 | 11 | 11853 | 1953 | 34943114 |
Cytomegalovirus test positive | 20.40 | 15.12 | 14 | 11850 | 3872 | 34941195 |
Polyp | 20.38 | 15.12 | 14 | 11850 | 3878 | 34941189 |
Chest discomfort | 20.28 | 15.12 | 52 | 11812 | 54478 | 34890589 |
Cytomegalovirus viraemia | 19.91 | 15.12 | 18 | 11846 | 7412 | 34937655 |
Pituitary tumour recurrent | 19.76 | 15.12 | 5 | 11859 | 100 | 34944967 |
Blood pressure increased | 19.51 | 15.12 | 70 | 11794 | 88032 | 34857035 |
Engraft failure | 19.39 | 15.12 | 7 | 11857 | 480 | 34944587 |
Overdose | 18.76 | 15.12 | 4 | 11860 | 91055 | 34854012 |
Oxygen saturation decreased | 18.66 | 15.12 | 50 | 11814 | 53768 | 34891299 |
Vein rupture | 18.31 | 15.12 | 8 | 11856 | 906 | 34944161 |
Toxic epidermal necrolysis | 18.19 | 15.12 | 29 | 11835 | 21617 | 34923450 |
White blood cell count decreased | 17.97 | 15.12 | 72 | 11792 | 95373 | 34849694 |
Chronic graft versus host disease | 16.70 | 15.12 | 13 | 11851 | 4360 | 34940707 |
Cerebellar tumour | 16.59 | 15.12 | 4 | 11860 | 65 | 34945002 |
Intentional product use issue | 16.32 | 15.12 | 51 | 11813 | 59765 | 34885302 |
Hepatic function abnormal | 16.17 | 15.12 | 42 | 11822 | 44321 | 34900746 |
Traumatic shock | 15.95 | 15.12 | 3 | 11861 | 13 | 34945054 |
MedDRA adverse event term | Likelihood ratio | Likelihood ratio threshold | Patients taking drug having adverse event | Patients taking drug not having adverse event | Patients not taking drug having adverse event | Patients not taking drug not having adverse event |
---|---|---|---|---|---|---|
Infusion related reaction | 284.04 | 12.79 | 371 | 26933 | 229866 | 79487218 |
Off label use | 98.63 | 12.79 | 587 | 26717 | 906628 | 78810456 |
Toxicity to various agents | 89.16 | 12.79 | 18 | 27286 | 421522 | 79295562 |
Nipple swelling | 79.02 | 12.79 | 19 | 27285 | 302 | 79716782 |
Urticaria | 75.69 | 12.79 | 184 | 27120 | 185017 | 79532067 |
Blood pressure fluctuation | 68.64 | 12.79 | 99 | 27205 | 67046 | 79650038 |
Intentional product use issue | 65.23 | 12.79 | 154 | 27150 | 151958 | 79565126 |
Flushing | 59.88 | 12.79 | 108 | 27196 | 88160 | 79628924 |
Nipple pain | 59.09 | 12.79 | 19 | 27285 | 907 | 79716177 |
Disseminated intravascular coagulation | 59.05 | 12.79 | 67 | 27237 | 35775 | 79681309 |
Febrile neutropenia | 58.50 | 12.79 | 193 | 27111 | 230806 | 79486278 |
Product use issue | 58.31 | 12.79 | 181 | 27123 | 209641 | 79507443 |
Pyrexia | 56.33 | 12.79 | 411 | 26893 | 678298 | 79038786 |
Drug interaction | 52.91 | 12.79 | 39 | 27265 | 415144 | 79301940 |
Blood pressure decreased | 45.14 | 12.79 | 103 | 27201 | 99363 | 79617721 |
Platelet count decreased | 43.46 | 12.79 | 156 | 27148 | 194508 | 79522576 |
Frequent bowel movements | 43.29 | 12.79 | 52 | 27252 | 29487 | 79687597 |
Cytomegalovirus viraemia | 42.07 | 12.79 | 35 | 27269 | 12786 | 79704298 |
Swollen joint count increased | 41.45 | 12.79 | 45 | 27259 | 22882 | 79694202 |
Death | 39.90 | 12.79 | 84 | 27220 | 566430 | 79150654 |
Inappropriate schedule of product administration | 39.65 | 12.79 | 118 | 27186 | 133510 | 79583574 |
Rheumatic fever | 38.22 | 12.79 | 48 | 27256 | 28477 | 79688607 |
Cytomegalovirus infection | 38.03 | 12.79 | 59 | 27245 | 42585 | 79674499 |
Fall | 36.29 | 12.79 | 70 | 27234 | 487559 | 79229525 |
Anaphylactic reaction | 32.89 | 12.79 | 82 | 27222 | 83661 | 79633423 |
Septic shock | 32.30 | 12.79 | 104 | 27200 | 122697 | 79594387 |
Bronchospasm | 31.99 | 12.79 | 41 | 27263 | 24818 | 79692266 |
Overdose | 31.21 | 12.79 | 12 | 27292 | 184194 | 79532890 |
Anaphylactic shock | 30.98 | 12.79 | 49 | 27255 | 35947 | 79681137 |
Poor venous access | 30.01 | 12.79 | 34 | 27270 | 18115 | 79698969 |
Chest discomfort | 29.41 | 12.79 | 109 | 27195 | 137935 | 79579149 |
Neutrophil count decreased | 28.84 | 12.79 | 84 | 27220 | 93875 | 79623209 |
Deep vein thrombosis postoperative | 28.52 | 12.79 | 26 | 27278 | 10726 | 79706358 |
Sciatica | 28.28 | 12.79 | 45 | 27259 | 33177 | 79683907 |
Shock | 27.89 | 12.79 | 52 | 27252 | 43496 | 79673588 |
Throat irritation | 27.62 | 12.79 | 50 | 27254 | 40896 | 79676188 |
Oxygen saturation decreased | 27.58 | 12.79 | 102 | 27202 | 128945 | 79588139 |
Blood pressure increased | 26.17 | 12.79 | 142 | 27162 | 211218 | 79505866 |
Intentional overdose | 25.82 | 12.79 | 3 | 27301 | 105957 | 79611127 |
Hypertension | 24.83 | 12.79 | 196 | 27108 | 330796 | 79386288 |
Oropharyngeal discomfort | 24.42 | 12.79 | 20 | 27284 | 7146 | 79709938 |
Erythema | 24.35 | 12.79 | 145 | 27159 | 223145 | 79493939 |
Heart rate irregular | 23.45 | 12.79 | 41 | 27263 | 32638 | 79684446 |
Pruritus | 21.04 | 12.79 | 217 | 27087 | 394431 | 79322653 |
Adrenocortical insufficiency acute | 20.86 | 12.79 | 13 | 27291 | 3030 | 79714054 |
Autoimmune disorder | 20.75 | 12.79 | 27 | 27277 | 16585 | 79700499 |
Mycobacterium chelonae infection | 20.74 | 12.79 | 12 | 27292 | 2444 | 79714640 |
Hepatic function abnormal | 20.21 | 12.79 | 63 | 27241 | 73044 | 79644040 |
Helicobacter infection | 20.13 | 12.79 | 61 | 27243 | 69643 | 79647441 |
Secondary immunodeficiency | 20.13 | 12.79 | 13 | 27291 | 3221 | 79713863 |
Myocardial infarction | 20.12 | 12.79 | 20 | 27284 | 184109 | 79532975 |
Colitis ulcerative | 19.22 | 12.79 | 39 | 27265 | 34703 | 79682381 |
Vascular rupture | 19.11 | 12.79 | 10 | 27294 | 1675 | 79715409 |
Cytomegalovirus test positive | 19.02 | 12.79 | 16 | 27288 | 5931 | 79711153 |
External ear cellulitis | 18.90 | 12.79 | 6 | 27298 | 275 | 79716809 |
Adrenal insufficiency | 18.22 | 12.79 | 34 | 27270 | 28453 | 79688631 |
Therapeutic product effect prolonged | 18.15 | 12.79 | 7 | 27297 | 572 | 79716512 |
Weight increased | 17.98 | 12.79 | 159 | 27145 | 277227 | 79439857 |
Heart rate increased | 17.65 | 12.79 | 85 | 27219 | 120639 | 79596445 |
Blood iron decreased | 17.61 | 12.79 | 24 | 27280 | 15410 | 79701674 |
Type 2 diabetes mellitus | 17.46 | 12.79 | 51 | 27253 | 57071 | 79660013 |
Vein rupture | 17.33 | 12.79 | 10 | 27294 | 2026 | 79715058 |
Duodenal ulcer perforation | 17.33 | 12.79 | 56 | 27248 | 66155 | 79650929 |
Drug level above therapeutic | 17.32 | 12.79 | 18 | 27286 | 8705 | 79708379 |
Chronic obstructive pulmonary disease | 17.30 | 12.79 | 4 | 27300 | 85415 | 79631669 |
Therapeutic response shortened | 17.10 | 12.79 | 24 | 27280 | 15839 | 79701245 |
Dislocation of vertebra | 16.99 | 12.79 | 17 | 27287 | 7863 | 79709221 |
Facet joint syndrome | 16.73 | 12.79 | 20 | 27284 | 11282 | 79705802 |
Pituitary tumour recurrent | 16.70 | 12.79 | 5 | 27299 | 188 | 79716896 |
Acute kidney injury | 16.57 | 12.79 | 107 | 27197 | 519297 | 79197787 |
Apocrine miliaria | 16.54 | 12.79 | 3 | 27301 | 10 | 79717074 |
Intentional product misuse | 16.45 | 12.79 | 6 | 27298 | 95159 | 79621925 |
Large intestine polyp | 16.41 | 12.79 | 21 | 27283 | 12687 | 79704397 |
Drug ineffective | 16.11 | 12.79 | 267 | 27037 | 1080646 | 78636438 |
Feeling hot | 16.07 | 12.79 | 51 | 27253 | 59683 | 79657401 |
Traumatic shock | 15.57 | 12.79 | 3 | 27301 | 15 | 79717069 |
Chills | 15.54 | 12.79 | 101 | 27203 | 160133 | 79556951 |
Antithrombin III decreased | 15.51 | 12.79 | 6 | 27298 | 494 | 79716590 |
X-ray abnormal | 15.30 | 12.79 | 14 | 27290 | 5799 | 79711285 |
Psoriatic arthropathy | 15.29 | 12.79 | 60 | 27244 | 77939 | 79639145 |
Cerebellar tumour | 14.85 | 12.79 | 4 | 27300 | 102 | 79716982 |
Suicide attempt | 14.72 | 12.79 | 5 | 27299 | 82927 | 79634157 |
Somnolence | 14.72 | 12.79 | 38 | 27266 | 238943 | 79478141 |
Aspartate aminotransferase increased | 14.44 | 12.79 | 89 | 27215 | 138552 | 79578532 |
Road traffic accident | 14.33 | 12.79 | 40 | 27264 | 43624 | 79673460 |
Genital rash | 14.28 | 12.79 | 7 | 27297 | 1021 | 79716063 |
Wheezing | 14.17 | 12.79 | 78 | 27226 | 116586 | 79600498 |
Lower limb fracture | 13.97 | 12.79 | 27 | 27277 | 23188 | 79693896 |
Phaeochromocytoma crisis | 13.96 | 12.79 | 5 | 27299 | 332 | 79716752 |
Intestinal resection | 13.90 | 12.79 | 11 | 27293 | 3746 | 79713338 |
White blood cell count decreased | 13.82 | 12.79 | 111 | 27193 | 188177 | 79528907 |
Heart rate decreased | 13.71 | 12.79 | 54 | 27250 | 70262 | 79646822 |
Cerebrovascular accident | 13.64 | 12.79 | 20 | 27284 | 155272 | 79561812 |
Liver disorder | 13.63 | 12.79 | 55 | 27249 | 72362 | 79644722 |
Tracheal inflammation | 13.50 | 12.79 | 4 | 27300 | 145 | 79716939 |
Abdominal pain | 13.28 | 12.79 | 197 | 27107 | 389372 | 79327712 |
Incorrect drug administration rate | 13.23 | 12.79 | 11 | 27293 | 4015 | 79713069 |
Injection site pain | 13.18 | 12.79 | 15 | 27289 | 129823 | 79587261 |
Ear pruritus | 13.02 | 12.79 | 11 | 27293 | 4104 | 79712980 |
Rheumatoid arthritis | 12.95 | 12.79 | 33 | 27271 | 208437 | 79508647 |
Pallor | 12.79 | 12.79 | 42 | 27262 | 50020 | 79667064 |
None
Source | Code | Description |
---|---|---|
FDA MoA | N0000175450 | Corticosteroid Hormone Receptor Agonists |
FDA EPC | N0000175576 | Corticosteroid |
MeSH PA | D000893 | Anti-Inflammatory Agents |
CHEBI has role | CHEBI:35472 | anti-inflammatory drugs |
CHEBI has role | CHEBI:49167 | anti-asthmatic drugs |
CHEBI has role | CHEBI:50857 | anti-allergic drugs |
CHEBI has role | CHEBI:75771 | Mus musculus metabolites |
CHEBI has role | CHEBI:77746 | Homo sapiens metabolite |
CHEBI has role | CHEBI:88188 | allergenic drug |
Disease | Relation | SNOMED_ID | DOID |
---|---|---|---|
Disorder of musculoskeletal system | indication | 928000 | DOID:17 |
Cerebral edema | indication | 2032001 | |
Berylliosis | indication | 8247009 | DOID:10322 |
Psoriasis | indication | 9014002 | DOID:8893 |
Ankylosing spondylitis | indication | 9631008 | DOID:7147 |
Rheumatic heart disease | indication | 23685000 | |
Atopic dermatitis | indication | 24079001 | DOID:3310 |
Inflammatory bowel disease | indication | 24526004 | DOID:0050589 |
Multiple sclerosis | indication | 24700007 | DOID:2377 |
Severe adrenal insufficiency | indication | 24867002 | |
Sarcoidosis | indication | 31541009 | DOID:11335 |
Idiopathic thrombocytopenic purpura | indication | 32273002 | DOID:8924 |
Psoriasis with arthropathy | indication | 33339001 | |
Crohn's disease | indication | 34000006 | |
Tendinitis | indication | 34840004 | DOID:971 |
Erythema multiforme | indication | 36715001 | |
Contact dermatitis | indication | 40275004 | DOID:2773 |
Angioedema | indication | 41291007 | DOID:1558 |
Humoral hypercalcemia of malignancy | indication | 47709007 | |
Articular gout | indication | 48440001 | DOID:13189 |
Edema of larynx | indication | 51599000 | |
Nephrotic syndrome | indication | 52254009 | DOID:1184 |
Systemic lupus erythematosus | indication | 55464009 | DOID:9074 |
Allergic rhinitis | indication | 61582004 | |
Lรถffler's syndrome | indication | 64936001 | DOID:9503 |
Pemphigus | indication | 65172003 | DOID:9182 |
Tenosynovitis | indication | 67801009 | DOID:970 |
Rheumatoid arthritis | indication | 69896004 | DOID:7148 |
Transfusion reaction due to serum protein reaction | indication | 72284000 | |
Acquired thrombocytopenia | indication | 74576004 | DOID:11126 |
Thyroiditis | indication | 82119001 | DOID:7166 |
Bursitis | indication | 84017003 | DOID:2965 |
Autoimmune disease | indication | 85828009 | |
Infection by larvae of Trichinella spiralis | indication | 88264003 | |
Congenital hypoplastic anemia | indication | 88854002 | DOID:1339 |
Acute lymphoid leukemia | indication | 91857003 | DOID:9952 |
Dermatitis herpetiformis | indication | 111196000 | DOID:8505 |
Hodgkin's disease | indication | 118599009 | |
Non-Hodgkin's lymphoma | indication | 118601006 | |
Mycosis fungoides | indication | 118618005 | |
Aspiration pneumonitis | indication | 155597006 | |
Asthma | indication | 195967001 | DOID:2841 |
Transplanted organ rejection | indication | 213148006 | |
Adrenogenital disorder | indication | 267395000 | DOID:0050811 |
Eruption of skin | indication | 271807003 | DOID:0050486 |
Disorder of eye | indication | 371405004 | DOID:5614 |
Primary adrenocortical insufficiency | indication | 373662000 | |
Adrenal cortical hypofunction | indication | 386584007 | DOID:10493 |
Erythroderma | indication | 399992009 | |
Autoimmune hemolytic anemia | indication | 413603009 | DOID:718 |
Synovitis | indication | 416209007 | DOID:2703 |
Post traumatic osteoarthritis | indication | 699262001 | |
Erythroblastic Anemia | indication | ||
Diagnostic Test for Cushing's Syndrome | indication | ||
Transfusion Reaction Urticaria | indication | ||
Systemic Dermatomyositis | indication | ||
Synovitis due to Osteoarthritis | indication | ||
Respiratory distress syndrome in the newborn | off-label use | 46775006 | |
Neonatal Bronchopulmonary Dysplasia | off-label use | ||
Mycosis | contraindication | 3218000 | DOID:1564 |
Ocular hypertension | contraindication | 4210003 | DOID:9282 |
Inactive tuberculosis | contraindication | 11999007 | |
Peptic ulcer | contraindication | 13200003 | DOID:750 |
Measles | contraindication | 14189004 | DOID:8622 |
Esophagitis | contraindication | 16761005 | DOID:11963 |
Mood swings | contraindication | 18963009 | |
Cirrhosis of liver | contraindication | 19943007 | DOID:5082 |
Glaucoma | contraindication | 23986001 | DOID:1686 |
Abscess of intestine | contraindication | 24557004 | |
Hypertensive disorder | contraindication | 38341003 | DOID:10763 |
Infectious disease | contraindication | 40733004 | |
Hypothyroidism | contraindication | 40930008 | DOID:1459 |
Hypokalemia | contraindication | 43339004 | |
Chronic heart failure | contraindication | 48447003 | |
Duodenal ulcer disease | contraindication | 51868009 | DOID:1724 |
Osteoporosis | contraindication | 64859006 | DOID:11476 |
Psychotic disorder | contraindication | 69322001 | |
Diabetes mellitus | contraindication | 73211009 | DOID:9351 |
Hypopituitarism | contraindication | 74728003 | DOID:9406 |
Hyperglycemia | contraindication | 80394007 | DOID:4195 |
Kidney disease | contraindication | 90708001 | DOID:557 |
Bilateral cataracts | contraindication | 95722004 | |
Eye infection | contraindication | 128351009 | |
Disorder of muscle | contraindication | 129565002 | DOID:423 |
Anastomosis of intestine | contraindication | 235407009 | |
Diverticulitis of gastrointestinal tract | contraindication | 271366000 | |
Varicella-zoster virus infection | contraindication | 309465005 | |
Viral eye infection | contraindication | 312132001 | |
Gastric ulcer | contraindication | 397825006 | DOID:10808 |
Exposure to varicella | contraindication | 444453009 |
None
None
Dissociation level | Dissociation constant | Type (acidic/basic) |
---|---|---|
pKa1 | 4.23 | acidic |
pKa2 | 12.94 | acidic |
None
None
Target | Class | Pharos | UniProt | Action | Type | Activity value (-log[M]) | Mechanism action | Bioact source | MoA source |
---|---|---|---|---|---|---|---|---|---|
Glucocorticoid receptor | Nuclear hormone receptor | AGONIST | CHEMBL | CHEMBL | |||||
Glucocorticoid receptor | Transcription factor | Kd | 6.72 | CHEMBL |
ID | Source |
---|---|
D00978 | KEGG_DRUG |
4017945 | VUID |
N0000146295 | NUI |
4017941 | VANDF |
4017945 | VANDF |
CHEBI:31677 | CHEBI |
CHEBI:17650 | CHEBI |
CHEMBL3989663 | ChEMBL_ID |
CHEMBL977 | ChEMBL_ID |
CHEMBL1200495 | ChEMBL_ID |
DB14545 | DRUGBANK_ID |
C007133 | MESH_SUPPLEMENTAL_RECORD_UI |
83784-20-7 | SECONDARY_CAS_RN |
16623 | PUBCHEM_CID |
DB00741 | DRUGBANK_ID |
21651 | RXNORM |
20708 | MMSL |
2500 | MMSL |
41706 | MMSL |
4837 | MMSL |
4843 | MMSL |
73114 | MMSL |
d00254 | MMSL |
002147 | NDDF |
002152 | NDDF |
005251 | NDDF |
109066000 | SNOMEDCT_US |
16602005 | SNOMEDCT_US |
396458002 | SNOMEDCT_US |
C0056387 | UMLSCUI |
C0020268 | UMLSCUI |
38 | INN_ID |
5754 | PUBCHEM_CID |
D006854 | MESH_DESCRIPTOR_UI |
50LQB69S1Z | UNII |
Product | Category | Ingredients | NDC | Form | Quantity | Route | Marketing | Label |
---|---|---|---|---|---|---|---|---|
Solu-Cortef | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0009-0005 | INJECTION, POWDER, FOR SOLUTION | 1000 mg | INTRAMUSCULAR | NDA | 22 sections |
Solu-Cortef | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0009-0011 | INJECTION, POWDER, FOR SOLUTION | 100 mg | INTRAMUSCULAR | NDA | 22 sections |
Solu-Cortef | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0009-0013 | INJECTION, POWDER, FOR SOLUTION | 250 mg | INTRAMUSCULAR | NDA | 22 sections |
Solu-Cortef | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0009-0016 | INJECTION, POWDER, FOR SOLUTION | 500 mg | INTRAMUSCULAR | NDA | 22 sections |
Solu-Cortef | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0009-0825 | INJECTION, POWDER, FOR SOLUTION | 100 mg | INTRAMUSCULAR | NDA | 22 sections |
SOLU-CORTEF | HUMAN PRESCRIPTION DRUG LABEL | 1 | 51662-1261 | INJECTION, POWDER, FOR SOLUTION | 100 mg | INTRAMUSCULAR | NDA | 13 sections |
SOLU-CORTEF | HUMAN PRESCRIPTION DRUG LABEL | 1 | 51662-1261 | INJECTION, POWDER, FOR SOLUTION | 100 mg | INTRAMUSCULAR | NDA | 13 sections |
SOLU-CORTEF | HUMAN PRESCRIPTION DRUG LABEL | 1 | 51662-1262 | INJECTION, POWDER, FOR SOLUTION | 250 mg | INTRAMUSCULAR | NDA | 13 sections |
SOLU-CORTEF | HUMAN PRESCRIPTION DRUG LABEL | 1 | 51662-1262 | INJECTION, POWDER, FOR SOLUTION | 250 mg | INTRAMUSCULAR | NDA | 13 sections |
Solu-Cortef | HUMAN PRESCRIPTION DRUG LABEL | 1 | 55154-3942 | INJECTION, POWDER, FOR SOLUTION | 100 mg | INTRAMUSCULAR | NDA | 22 sections |
Solu-Cortef | HUMAN PRESCRIPTION DRUG LABEL | 1 | 55154-3942 | INJECTION, POWDER, FOR SOLUTION | 100 mg | INTRAMUSCULAR | NDA | 22 sections |
Solu-Cortef | HUMAN PRESCRIPTION DRUG LABEL | 1 | 55154-3942 | INJECTION, POWDER, FOR SOLUTION | 100 mg | INTRAMUSCULAR | NDA | 22 sections |