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| Stem definition | Drug id | CAS RN |
|---|---|---|
| corticosteroids, except prednisolone derivatives | 4456 | 125-04-2 |
None
| Property | Value | Reference |
|---|---|---|
| S (Water solubility) | 0.23 mg/mL | Bocci G, Oprea TI, Benet LZ |
| Property | Description | Value | Unit | Confidence | Similarity |
|---|---|---|---|---|---|
| kinase-safety-class | ACVR2B,AXL,CAMK2D,CDK5,CDK9,EIF2AK3,ERBB2,GRK2,ITK,MAPK7,NTRK2,PDK1,PDK2,PRKDC,TEK,TGFBR1 | 16 | |||
| kinase-selectivity-class | EIF2AK3,GRK2,MAP2K6 | 3 | |||
| mdck-mdr1-bcrp-efflux | MDCK-MDR1-BCRP efflux ratio | 0.933 | Moderate | 0.70 | |
| pfas-class | PFAS structural alert (1 = True, 0 = False) | 0 | |||
| rat-kpuu-brain | Rat brain Kpuu | 0.010 | % | Moderate | 0.70 |
| Date | Agency | Company | Orphan |
|---|---|---|---|
| April 27, 1955 | FDA | PHARMACIA AND UPJOHN |
| MedDRA adverse event term | Likelihood ratio | Likelihood ratio threshold | Patients taking drug having adverse event | Patients taking drug not having adverse event | Patients not taking drug having adverse event | Patients not taking drug not having adverse event |
|---|---|---|---|---|---|---|
| Infusion related reaction | 253.16 | 14.91 | 763 | 64157 | 416017 | 90147510 |
| Rheumatic fever | 221.42 | 14.91 | 395 | 64525 | 152726 | 90410801 |
| Dislocation of vertebra | 219.19 | 14.91 | 234 | 64686 | 55734 | 90507793 |
| Drug ineffective | 215.09 | 14.91 | 418 | 64502 | 1383880 | 89179647 |
| Sciatica | 205.72 | 14.91 | 305 | 64615 | 101077 | 90462450 |
| Wound infection | 200.15 | 14.91 | 309 | 64611 | 106093 | 90457434 |
| Joint range of motion decreased | 194.91 | 14.91 | 349 | 64571 | 135294 | 90428233 |
| Adjustment disorder with depressed mood | 194.07 | 14.91 | 221 | 64699 | 56532 | 90506995 |
| Type 2 diabetes mellitus | 192.89 | 14.91 | 440 | 64480 | 202804 | 90360723 |
| Swollen joint count increased | 191.30 | 14.91 | 310 | 64610 | 110896 | 90452631 |
| Toxicity to various agents | 182.91 | 14.91 | 5 | 64915 | 287841 | 90275686 |
| Retinitis | 179.98 | 14.91 | 177 | 64743 | 38281 | 90525246 |
| Injury | 178.21 | 14.91 | 419 | 64501 | 196930 | 90366597 |
| Lupus-like syndrome | 176.91 | 14.91 | 196 | 64724 | 48650 | 90514877 |
| X-ray abnormal | 167.50 | 14.91 | 184 | 64736 | 45240 | 90518287 |
| Joint dislocation | 165.10 | 14.91 | 181 | 64739 | 44401 | 90519126 |
| Road traffic accident | 161.13 | 14.91 | 282 | 64638 | 107344 | 90456183 |
| Porphyria acute | 160.82 | 14.91 | 120 | 64800 | 17855 | 90545672 |
| Deep vein thrombosis postoperative | 159.66 | 14.91 | 224 | 64696 | 70585 | 90492942 |
| Facet joint syndrome | 156.74 | 14.91 | 265 | 64655 | 98124 | 90465403 |
| Impaired healing | 155.51 | 14.91 | 443 | 64477 | 233756 | 90329771 |
| Lower limb fracture | 153.05 | 14.91 | 242 | 64678 | 84771 | 90478756 |
| Walking aid user | 150.70 | 14.91 | 155 | 64765 | 35351 | 90528176 |
| Helicobacter infection | 150.51 | 14.91 | 429 | 64491 | 226421 | 90337106 |
| Grip strength decreased | 145.69 | 14.91 | 248 | 64672 | 92328 | 90471199 |
| Sleep disorder due to general medical condition, insomnia type | 145.33 | 14.91 | 299 | 64621 | 128395 | 90435132 |
| Fibromyalgia | 144.61 | 14.91 | 398 | 64522 | 205871 | 90357656 |
| Hypercholesterolaemia | 144.13 | 14.91 | 259 | 64661 | 100633 | 90462894 |
| Wheezing | 140.59 | 14.91 | 432 | 64488 | 237648 | 90325879 |
| Psoriatic arthropathy | 140.15 | 14.91 | 420 | 64500 | 227915 | 90335612 |
| Drug interaction | 137.12 | 14.91 | 18 | 64902 | 276435 | 90287092 |
| Urticaria | 135.87 | 14.91 | 512 | 64408 | 312222 | 90251305 |
| Prescribed underdose | 132.89 | 14.91 | 212 | 64708 | 74807 | 90488720 |
| Liver disorder | 132.53 | 14.91 | 278 | 64642 | 120991 | 90442536 |
| Fall | 130.67 | 14.91 | 93 | 64827 | 481717 | 90081810 |
| Lupus vulgaris | 130.14 | 14.91 | 161 | 64759 | 44898 | 90518629 |
| Delirium | 129.23 | 14.91 | 252 | 64668 | 104107 | 90459420 |
| Rheumatoid factor positive | 125.08 | 14.91 | 336 | 64584 | 171314 | 90392213 |
| Hepatic cirrhosis | 124.98 | 14.91 | 188 | 64732 | 63065 | 90500462 |
| Irritable bowel syndrome | 123.92 | 14.91 | 378 | 64542 | 207070 | 90356457 |
| Autoimmune disorder | 121.28 | 14.91 | 206 | 64714 | 76538 | 90486989 |
| Exostosis | 121.12 | 14.91 | 169 | 64751 | 52965 | 90510562 |
| Laryngitis | 118.04 | 14.91 | 163 | 64757 | 50590 | 90512937 |
| Lip dry | 118.04 | 14.91 | 238 | 64682 | 100717 | 90462810 |
| Folliculitis | 113.41 | 14.91 | 363 | 64557 | 203990 | 90359537 |
| Seronegative arthritis | 112.62 | 14.91 | 98 | 64822 | 18136 | 90545391 |
| Wound | 109.14 | 14.91 | 468 | 64452 | 302512 | 90261015 |
| Duodenal ulcer perforation | 104.20 | 14.91 | 372 | 64548 | 220916 | 90342611 |
| Foot deformity | 102.12 | 14.91 | 166 | 64754 | 59485 | 90504042 |
| Hand deformity | 101.56 | 14.91 | 451 | 64469 | 295911 | 90267616 |
| C-reactive protein abnormal | 98.45 | 14.91 | 255 | 64665 | 127174 | 90436353 |
| Bone erosion | 98.27 | 14.91 | 153 | 64767 | 52868 | 90510659 |
| Anti-cyclic citrullinated peptide antibody | 98.15 | 14.91 | 109 | 64811 | 27112 | 90536415 |
| Acute kidney injury | 96.17 | 14.91 | 55 | 64865 | 320332 | 90243195 |
| Pulmonary fibrosis | 95.58 | 14.91 | 227 | 64693 | 107276 | 90456251 |
| Hip arthroplasty | 94.29 | 14.91 | 184 | 64736 | 76024 | 90487503 |
| C-reactive protein | 93.68 | 14.91 | 114 | 64806 | 31253 | 90532274 |
| Ear infection | 91.90 | 14.91 | 173 | 64747 | 69602 | 90493925 |
| Ill-defined disorder | 91.49 | 14.91 | 316 | 64604 | 184575 | 90378952 |
| Hypoaesthesia | 89.33 | 14.91 | 453 | 64467 | 313757 | 90249770 |
| Muscle injury | 89.23 | 14.91 | 304 | 64616 | 176350 | 90387177 |
| Amnesia | 87.82 | 14.91 | 221 | 64699 | 108284 | 90455243 |
| Joint stiffness | 87.68 | 14.91 | 181 | 64739 | 77861 | 90485666 |
| Oedema | 83.65 | 14.91 | 324 | 64596 | 199971 | 90363556 |
| Prescribed overdose | 83.40 | 14.91 | 203 | 64717 | 97422 | 90466105 |
| Injection site pain | 82.16 | 14.91 | 13 | 64907 | 173686 | 90389841 |
| Disability | 80.32 | 14.91 | 121 | 64799 | 40624 | 90522903 |
| Infection | 79.58 | 14.91 | 487 | 64433 | 361607 | 90201920 |
| Glossodynia | 79.25 | 14.91 | 446 | 64474 | 321333 | 90242194 |
| Frequent bowel movements | 78.53 | 14.91 | 144 | 64776 | 56791 | 90506736 |
| Product dose omission issue | 76.79 | 14.91 | 58 | 64862 | 291629 | 90271898 |
| Inflammation | 75.47 | 14.91 | 290 | 64630 | 178302 | 90385225 |
| Dry mouth | 75.44 | 14.91 | 296 | 64624 | 183763 | 90379764 |
| Osteoporosis | 75.40 | 14.91 | 194 | 64726 | 96337 | 90467190 |
| Breast cancer stage III | 74.71 | 14.91 | 178 | 64742 | 84269 | 90479258 |
| Sleep disorder | 73.64 | 14.91 | 309 | 64611 | 197721 | 90365806 |
| Constipation | 68.51 | 14.91 | 60 | 64860 | 280335 | 90283192 |
| Colitis ulcerative | 67.95 | 14.91 | 140 | 64780 | 60126 | 90503401 |
| Liver injury | 67.23 | 14.91 | 271 | 64649 | 170296 | 90393231 |
| Visual impairment | 67 | 14.91 | 228 | 64692 | 132137 | 90431390 |
| Pericarditis | 66.86 | 14.91 | 375 | 64545 | 269776 | 90293751 |
| Feeling hot | 64.28 | 14.91 | 160 | 64760 | 77848 | 90485679 |
| Night sweats | 63.60 | 14.91 | 220 | 64700 | 128546 | 90434981 |
| Disease progression | 63.18 | 14.91 | 17 | 64903 | 156598 | 90406929 |
| Anaemia | 63.03 | 14.91 | 97 | 64823 | 352705 | 90210822 |
| Death | 62.74 | 14.91 | 147 | 64773 | 456404 | 90107123 |
| Red blood cell sedimentation rate increased | 61.44 | 14.91 | 163 | 64757 | 82432 | 90481095 |
| Gait inability | 61.19 | 14.91 | 237 | 64683 | 146219 | 90417308 |
| Synovitis | 60.53 | 14.91 | 424 | 64496 | 329328 | 90234199 |
| Hypersensitivity | 60.10 | 14.91 | 542 | 64378 | 454135 | 90109392 |
| Peripheral venous disease | 59.79 | 14.91 | 163 | 64757 | 83758 | 90479769 |
| Lung disorder | 59.75 | 14.91 | 239 | 64681 | 149644 | 90413883 |
| Knee arthroplasty | 58.70 | 14.91 | 161 | 64759 | 83021 | 90480506 |
| Somnolence | 57.06 | 14.91 | 40 | 64880 | 209044 | 90354483 |
| Weight increased | 56.66 | 14.91 | 501 | 64419 | 417426 | 90146101 |
| Musculoskeletal stiffness | 56.61 | 14.91 | 385 | 64535 | 296147 | 90267380 |
| Stomatitis | 53.23 | 14.91 | 358 | 64562 | 274340 | 90289187 |
| Hypertension | 50.41 | 14.91 | 525 | 64395 | 457007 | 90106520 |
| Urinary tract infection | 49.95 | 14.91 | 89 | 64831 | 305543 | 90257984 |
| Systemic lupus erythematosus | 49.63 | 14.91 | 435 | 64485 | 361461 | 90202066 |
| Intentional overdose | 49.25 | 14.91 | 5 | 64915 | 93829 | 90469698 |
| Spinal fusion surgery | 49.20 | 14.91 | 52 | 64868 | 12231 | 90551296 |
| Cerebrovascular accident | 48.72 | 14.91 | 14 | 64906 | 123519 | 90440008 |
| Malignant neoplasm progression | 48.32 | 14.91 | 9 | 64911 | 106861 | 90456666 |
| Sinusitis | 47.36 | 14.91 | 413 | 64507 | 342675 | 90220852 |
| Underdose | 46.84 | 14.91 | 113 | 64807 | 53904 | 90509623 |
| Spondylitis | 44.74 | 14.91 | 53 | 64867 | 14125 | 90549402 |
| Osteoarthritis | 44.67 | 14.91 | 266 | 64654 | 195464 | 90368063 |
| Discomfort | 44.17 | 14.91 | 342 | 64578 | 273993 | 90289534 |
| Hepatic enzyme increased | 43.59 | 14.91 | 422 | 64498 | 360314 | 90203213 |
| Neuropathy peripheral | 43.27 | 14.91 | 22 | 64898 | 136948 | 90426579 |
| Maternal exposure timing unspecified | 43.22 | 14.91 | 66 | 64854 | 22417 | 90541110 |
| Pulmonary embolism | 42.86 | 14.91 | 20 | 64900 | 130800 | 90432727 |
| Blood cholesterol increased | 42.03 | 14.91 | 274 | 64646 | 207738 | 90355789 |
| Obesity | 41.84 | 14.91 | 168 | 64752 | 105339 | 90458188 |
| Bursitis | 41.77 | 14.91 | 196 | 64724 | 131458 | 90432069 |
| Sleep disorder due to a general medical condition | 41.40 | 14.91 | 96 | 64824 | 44642 | 90518885 |
| Suicidal ideation | 41.31 | 14.91 | 3 | 64917 | 73852 | 90489675 |
| Chronic obstructive pulmonary disease | 41.30 | 14.91 | 3 | 64917 | 73826 | 90489701 |
| Blister | 41.11 | 14.91 | 318 | 64602 | 254680 | 90308847 |
| Injection site erythema | 41.05 | 14.91 | 10 | 64910 | 98492 | 90465035 |
| Seizure | 40.59 | 14.91 | 30 | 64890 | 152599 | 90410928 |
| Coma | 40.49 | 14.91 | 3 | 64917 | 72629 | 90490898 |
| Drug tolerance decreased | 40.24 | 14.91 | 78 | 64842 | 32052 | 90531475 |
| Balance disorder | 40.18 | 14.91 | 10 | 64910 | 97070 | 90466457 |
| Cough | 40.10 | 14.91 | 133 | 64787 | 368829 | 90194698 |
| Mobility decreased | 40.04 | 14.91 | 312 | 64608 | 250422 | 90313105 |
| Myocardial infarction | 38.27 | 14.91 | 14 | 64906 | 105958 | 90457569 |
| Intentional product use issue | 36.93 | 14.91 | 274 | 64646 | 216618 | 90346909 |
| Dehydration | 35.13 | 14.91 | 53 | 64867 | 194394 | 90369133 |
| Hypotension | 34.87 | 14.91 | 118 | 64802 | 325279 | 90238248 |
| Suicide attempt | 34.84 | 14.91 | 6 | 64914 | 75393 | 90488134 |
| Wrong technique in product usage process | 34.65 | 14.91 | 5 | 64915 | 71566 | 90491961 |
| Medication error | 34.53 | 14.91 | 136 | 64784 | 84516 | 90479011 |
| General physical health deterioration | 34.25 | 14.91 | 397 | 64523 | 354718 | 90208809 |
| Grip strength | 34.22 | 14.91 | 37 | 64883 | 8928 | 90554599 |
| Blood glucose increased | 33.70 | 14.91 | 13 | 64907 | 95233 | 90468294 |
| Nausea | 33.22 | 14.91 | 578 | 64342 | 1109738 | 89453789 |
| Pemphigus | 33.13 | 14.91 | 369 | 64551 | 326495 | 90237032 |
| Influenza | 32.56 | 14.91 | 31 | 64889 | 139233 | 90424294 |
| Weight fluctuation | 32.49 | 14.91 | 54 | 64866 | 19695 | 90543832 |
| Cardiac failure congestive | 30.95 | 14.91 | 16 | 64904 | 98678 | 90464849 |
| Atrial fibrillation | 30.94 | 14.91 | 30 | 64890 | 133581 | 90429946 |
| Mucosal inflammation | 30.43 | 14.91 | 3 | 64917 | 57622 | 90505905 |
| Hyponatraemia | 29.76 | 14.91 | 31 | 64889 | 133507 | 90430020 |
| Haemoglobin decreased | 29.40 | 14.91 | 44 | 64876 | 161912 | 90401615 |
| Cataract | 28.74 | 14.91 | 8 | 64912 | 72084 | 90491443 |
| Influenza like illness | 28.52 | 14.91 | 11 | 64909 | 80600 | 90482927 |
| Contusion | 28.43 | 14.91 | 290 | 64630 | 250926 | 90312601 |
| Swollen joint count | 28.39 | 14.91 | 33 | 64887 | 8620 | 90554907 |
| Fatigue | 28.35 | 14.91 | 621 | 64299 | 1153402 | 89410125 |
| Respiratory disorder | 27.96 | 14.91 | 106 | 64814 | 64710 | 90498817 |
| Musculoskeletal pain | 27.82 | 14.91 | 214 | 64706 | 171037 | 90392490 |
| Upper respiratory tract infection | 27.74 | 14.91 | 172 | 64748 | 128146 | 90435381 |
| Back pain | 27.59 | 14.91 | 125 | 64795 | 317050 | 90246477 |
| Gastrooesophageal reflux disease | 27.55 | 14.91 | 48 | 64872 | 166289 | 90397238 |
| Cardiac arrest | 27.41 | 14.91 | 21 | 64899 | 104914 | 90458613 |
| Bradycardia | 27.18 | 14.91 | 13 | 64907 | 83834 | 90479693 |
| Injection site swelling | 27.13 | 14.91 | 5 | 64915 | 59834 | 90503693 |
| Anti-cyclic citrullinated peptide antibody positive | 26.31 | 14.91 | 272 | 64648 | 236161 | 90327366 |
| Drug-induced liver injury | 26.15 | 14.91 | 131 | 64789 | 90187 | 90473340 |
| Neutropenia | 25.86 | 14.91 | 79 | 64841 | 224825 | 90338702 |
| Rectal haemorrhage | 25.37 | 14.91 | 122 | 64798 | 82622 | 90480905 |
| C-reactive protein increased | 25.32 | 14.91 | 219 | 64701 | 181170 | 90382357 |
| Vision blurred | 25.26 | 14.91 | 25 | 64895 | 110268 | 90453259 |
| Lethargy | 25.18 | 14.91 | 7 | 64913 | 63132 | 90500395 |
| Weight decreased | 24.80 | 14.91 | 396 | 64524 | 379514 | 90184013 |
| Herpes zoster | 24.65 | 14.91 | 19 | 64901 | 94625 | 90468902 |
| Swelling | 24.49 | 14.91 | 429 | 64491 | 418629 | 90144898 |
| Feeling abnormal | 24.44 | 14.91 | 52 | 64868 | 167183 | 90396344 |
| Renal failure | 24.35 | 14.91 | 35 | 64885 | 130972 | 90432555 |
| Syncope | 24.11 | 14.91 | 36 | 64884 | 132627 | 90430900 |
| Cognitive disorder | 23.69 | 14.91 | 10 | 64910 | 69397 | 90494130 |
| Subcutaneous drug absorption impaired | 23.59 | 14.91 | 38 | 64882 | 13507 | 90550020 |
| Cardiac disorder | 23.26 | 14.91 | 6 | 64914 | 56866 | 90506661 |
| Chronic kidney disease | 23.18 | 14.91 | 4 | 64916 | 50187 | 90513340 |
| Oedema peripheral | 22.94 | 14.91 | 284 | 64636 | 257631 | 90305896 |
| Thrombosis | 22.78 | 14.91 | 12 | 64908 | 73239 | 90490288 |
| Insomnia | 22.67 | 14.91 | 350 | 64570 | 333124 | 90230403 |
| Breast cancer stage II | 22.58 | 14.91 | 66 | 64854 | 35268 | 90528259 |
| Injection site bruising | 22.41 | 14.91 | 5 | 64915 | 52302 | 90511225 |
| Vertigo | 22.36 | 14.91 | 11 | 64909 | 69800 | 90493727 |
| Dyspnoea exertional | 22.25 | 14.91 | 12 | 64908 | 72276 | 90491251 |
| Overdose | 22.25 | 14.91 | 50 | 64870 | 157659 | 90405868 |
| Intentional product misuse | 22.07 | 14.91 | 19 | 64901 | 89585 | 90473942 |
| Unevaluable event | 22.02 | 14.91 | 6 | 64914 | 54842 | 90508685 |
| White blood cell count increased | 21.97 | 14.91 | 101 | 64819 | 67140 | 90496387 |
| Hyperhidrosis | 21.97 | 14.91 | 40 | 64880 | 136265 | 90427262 |
| Ascites | 21.62 | 14.91 | 4 | 64916 | 47736 | 90515791 |
| General symptom | 21.36 | 14.91 | 38 | 64882 | 14630 | 90548897 |
| Breast cancer stage I | 21.02 | 14.91 | 30 | 64890 | 9594 | 90553933 |
| Transient ischaemic attack | 20.94 | 14.91 | 3 | 64917 | 43173 | 90520354 |
| Pleural effusion | 20.73 | 14.91 | 30 | 64890 | 111961 | 90451566 |
| Femur fracture | 20.57 | 14.91 | 4 | 64916 | 46078 | 90517449 |
| Myalgia | 20.50 | 14.91 | 61 | 64859 | 175064 | 90388463 |
| Pruritus | 20.43 | 14.91 | 520 | 64400 | 541005 | 90022522 |
| Rheumatoid arthritis | 20.41 | 14.91 | 164 | 64756 | 362450 | 90201077 |
| Diverticulitis | 20.01 | 14.91 | 4 | 64916 | 45183 | 90518344 |
| Muscular weakness | 19.87 | 14.91 | 231 | 64689 | 206435 | 90357092 |
| Renal impairment | 19.75 | 14.91 | 28 | 64892 | 105393 | 90458134 |
| Pain in jaw | 19.74 | 14.91 | 5 | 64915 | 47980 | 90515547 |
| Deep vein thrombosis | 19.60 | 14.91 | 22 | 64898 | 91598 | 90471929 |
| Electrocardiogram QT prolonged | 19.57 | 14.91 | 14 | 64906 | 72442 | 90491085 |
| Dyspepsia | 18.83 | 14.91 | 221 | 64699 | 197939 | 90365588 |
| Pain | 18.81 | 14.91 | 557 | 64363 | 995784 | 89567743 |
| Epistaxis | 18.70 | 14.91 | 20 | 64900 | 85105 | 90478422 |
| Drug reaction with eosinophilia and systemic symptoms | 18.49 | 14.91 | 4 | 64916 | 42754 | 90520773 |
| Osteonecrosis of jaw | 18.31 | 14.91 | 3 | 64917 | 39100 | 90524427 |
| Colitis | 18.26 | 14.91 | 14 | 64906 | 69928 | 90493599 |
| COVID-19 | 18.22 | 14.91 | 61 | 64859 | 168782 | 90394745 |
| Flushing | 18.12 | 14.91 | 117 | 64803 | 88374 | 90475153 |
| Abortion spontaneous | 18.11 | 14.91 | 8 | 64912 | 54048 | 90509479 |
| Adverse event | 18.11 | 14.91 | 145 | 64775 | 117273 | 90446254 |
| Sedation | 18.02 | 14.91 | 6 | 64914 | 48165 | 90515362 |
| Gastrointestinal haemorrhage | 17.89 | 14.91 | 23 | 64897 | 90225 | 90473302 |
| Rash vesicular | 17.89 | 14.91 | 40 | 64880 | 18157 | 90545370 |
| Liver function test abnormal | 17.88 | 14.91 | 7 | 64913 | 50838 | 90512689 |
| External ear cellulitis | 17.81 | 14.91 | 7 | 64913 | 284 | 90563243 |
| Endometritis decidual | 17.65 | 14.91 | 4 | 64916 | 21 | 90563506 |
| Flatulence | 17.63 | 14.91 | 4 | 64916 | 41363 | 90522164 |
| Dysphagia | 17.17 | 14.91 | 34 | 64886 | 112244 | 90451283 |
| Blood creatinine increased | 17.02 | 14.91 | 29 | 64891 | 101357 | 90462170 |
| Hypoglycaemia | 16.97 | 14.91 | 15 | 64905 | 69833 | 90493694 |
| Angioedema | 16.92 | 14.91 | 13 | 64907 | 64863 | 90498664 |
| Dysarthria | 16.83 | 14.91 | 9 | 64911 | 54473 | 90509054 |
| Swollen tongue | 16.71 | 14.91 | 6 | 64914 | 45950 | 90517577 |
| Cholestasis | 16.53 | 14.91 | 3 | 64917 | 36296 | 90527231 |
| Therapy non-responder | 16.51 | 14.91 | 160 | 64760 | 136544 | 90426983 |
| Injection site pruritus | 16.47 | 14.91 | 9 | 64911 | 53825 | 90509702 |
| Breast cancer | 16.43 | 14.91 | 9 | 64911 | 53752 | 90509775 |
| Asthma | 16.38 | 14.91 | 254 | 64666 | 241906 | 90321621 |
| Loss of consciousness | 16.30 | 14.91 | 49 | 64871 | 140189 | 90423338 |
| Hallucination | 16.23 | 14.91 | 14 | 64906 | 65945 | 90497582 |
| Haematoma | 16.20 | 14.91 | 4 | 64916 | 39044 | 90524483 |
| Lactic acidosis | 16.09 | 14.91 | 8 | 64912 | 50455 | 90513072 |
| Skin exfoliation | 16.01 | 14.91 | 15 | 64905 | 67898 | 90495629 |
| Live birth | 15.83 | 14.91 | 104 | 64816 | 79003 | 90484524 |
| Interstitial lung disease | 15.64 | 14.91 | 19 | 64901 | 76386 | 90487141 |
| Polyglandular disorder | 15.64 | 14.91 | 6 | 64914 | 228 | 90563299 |
| Asthenia | 15.51 | 14.91 | 279 | 64641 | 533472 | 90030055 |
| Hypercalcaemia | 15.23 | 14.91 | 3 | 64917 | 34237 | 90529290 |
| Hepatitis | 15.11 | 14.91 | 17 | 64903 | 70722 | 90492805 |
| Rhabdomyolysis | 15.07 | 14.91 | 9 | 64911 | 51247 | 90512280 |
| Depressed level of consciousness | 15.00 | 14.91 | 18 | 64902 | 72766 | 90490761 |
| Foetal exposure during pregnancy | 14.98 | 14.91 | 6 | 64914 | 42969 | 90520558 |
| Myelosuppression | 14.94 | 14.91 | 10 | 64910 | 53581 | 90509946 |
| MedDRA adverse event term | Likelihood ratio | Likelihood ratio threshold | Patients taking drug having adverse event | Patients taking drug not having adverse event | Patients not taking drug having adverse event | Patients not taking drug not having adverse event |
|---|---|---|---|---|---|---|
| Infusion related reaction | 313.13 | 14.88 | 220 | 14949 | 60586 | 42545580 |
| Nipple swelling | 99.40 | 14.88 | 24 | 15145 | 373 | 42605793 |
| Mechanical ventilation complication | 85.76 | 14.88 | 24 | 15145 | 680 | 42605486 |
| Nipple pain | 79.62 | 14.88 | 25 | 15144 | 1062 | 42605104 |
| Anaphylactic reaction | 64.84 | 14.88 | 78 | 15091 | 42665 | 42563501 |
| Anaphylactic shock | 60.80 | 14.88 | 57 | 15112 | 23460 | 42582706 |
| Pyrexia | 60.22 | 14.88 | 288 | 14881 | 393754 | 42212412 |
| Disseminated intravascular coagulation | 56.38 | 14.88 | 56 | 15113 | 24738 | 42581428 |
| Urticaria | 54.63 | 14.88 | 96 | 15073 | 73940 | 42532226 |
| Flushing | 53.60 | 14.88 | 66 | 15103 | 36962 | 42569204 |
| Inspiratory capacity decreased | 48.94 | 14.88 | 23 | 15146 | 2944 | 42603222 |
| Febrile neutropenia | 47.85 | 14.88 | 160 | 15009 | 185543 | 42420623 |
| Haemothorax | 44.41 | 14.88 | 26 | 15143 | 5210 | 42600956 |
| Blood pressure fluctuation | 43.93 | 14.88 | 51 | 15118 | 26857 | 42579309 |
| Adverse reaction | 42.47 | 14.88 | 23 | 15146 | 3970 | 42602196 |
| Polyp | 42.03 | 14.88 | 24 | 15145 | 4590 | 42601576 |
| Blood iron decreased | 39.91 | 14.88 | 26 | 15143 | 6292 | 42599874 |
| Toxicity to various agents | 39.63 | 14.88 | 16 | 15153 | 229120 | 42377046 |
| Angiopathy | 38.63 | 14.88 | 24 | 15145 | 5353 | 42600813 |
| Platelet count decreased | 36.18 | 14.88 | 120 | 15049 | 138461 | 42467705 |
| Blood pressure increased | 32.85 | 14.88 | 95 | 15074 | 101833 | 42504333 |
| Drug interaction | 31.75 | 14.88 | 29 | 15140 | 266970 | 42339196 |
| Face oedema | 31.30 | 14.88 | 31 | 15138 | 13635 | 42592531 |
| Death | 31.04 | 14.88 | 77 | 15092 | 471108 | 42135058 |
| Chills | 30.62 | 14.88 | 88 | 15081 | 93978 | 42512188 |
| Large intestine polyp | 28.96 | 14.88 | 25 | 15144 | 9240 | 42596926 |
| Cerebellar tumour | 27.92 | 14.88 | 7 | 15162 | 128 | 42606038 |
| Enterococcus test positive | 27.60 | 14.88 | 13 | 15156 | 1672 | 42604494 |
| Frequent bowel movements | 27.55 | 14.88 | 36 | 15133 | 21371 | 42584795 |
| Hypersensitivity | 26.82 | 14.88 | 71 | 15098 | 72299 | 42533867 |
| Emphysema | 25.55 | 14.88 | 26 | 15143 | 11809 | 42594357 |
| Neutrophil count decreased | 25.33 | 14.88 | 64 | 15105 | 63351 | 42542815 |
| Myoglobinaemia | 24.92 | 14.88 | 7 | 15162 | 201 | 42605965 |
| Overdose | 24.55 | 14.88 | 4 | 15165 | 105260 | 42500906 |
| Blood pressure decreased | 24.49 | 14.88 | 60 | 15109 | 58272 | 42547894 |
| Septic shock | 24.45 | 14.88 | 80 | 15089 | 91592 | 42514574 |
| Shock haemorrhagic | 23.57 | 14.88 | 29 | 15140 | 16213 | 42589953 |
| Oxygen saturation decreased | 23.50 | 14.88 | 63 | 15106 | 64624 | 42541542 |
| Posthaemorrhagic hydrocephalus | 23.42 | 14.88 | 6 | 15163 | 120 | 42606046 |
| Adrenal insufficiency | 23.08 | 14.88 | 31 | 15138 | 18893 | 42587273 |
| Off label use | 22.68 | 14.88 | 335 | 14834 | 638000 | 41968166 |
| Therapeutic product effect prolonged | 21.99 | 14.88 | 7 | 15162 | 311 | 42605855 |
| Intentional product use issue | 21.27 | 14.88 | 65 | 15104 | 71768 | 42534398 |
| Hypovolaemia | 20.83 | 14.88 | 23 | 15146 | 11462 | 42594704 |
| Pneumothorax | 20.64 | 14.88 | 33 | 15136 | 23510 | 42582656 |
| Middle ear inflammation | 20.50 | 14.88 | 6 | 15163 | 200 | 42605966 |
| Cytomegalovirus infection | 20.16 | 14.88 | 39 | 15130 | 32267 | 42573899 |
| Pituitary tumour recurrent | 19.97 | 14.88 | 5 | 15164 | 91 | 42606075 |
| Abdominal discomfort | 19.46 | 14.88 | 65 | 15104 | 75190 | 42530976 |
| Steroid dependence | 18.74 | 14.88 | 17 | 15152 | 6705 | 42599461 |
| Cytomegalovirus test positive | 18.47 | 14.88 | 14 | 15155 | 4305 | 42601861 |
| White blood cell count decreased | 18.43 | 14.88 | 83 | 15086 | 110313 | 42495853 |
| Antithrombin III decreased | 17.95 | 14.88 | 7 | 15162 | 567 | 42605599 |
| Product use issue | 17.85 | 14.88 | 64 | 15105 | 76687 | 42529479 |
| Engraft failure | 17.84 | 14.88 | 7 | 15162 | 576 | 42605590 |
| Epstein-Barr virus associated lymphoproliferative disorder | 17.79 | 14.88 | 11 | 15158 | 2432 | 42603734 |
| Heart rate irregular | 17.63 | 14.88 | 25 | 15144 | 16025 | 42590141 |
| Herpes dermatitis | 17.62 | 14.88 | 5 | 15164 | 149 | 42606017 |
| Vein rupture | 17.42 | 14.88 | 8 | 15161 | 971 | 42605195 |
| Acute graft versus host disease in skin | 17.30 | 14.88 | 17 | 15152 | 7407 | 42598759 |
| Infection | 17.04 | 14.88 | 82 | 15087 | 111986 | 42494180 |
| Pallor | 16.97 | 14.88 | 34 | 15135 | 28852 | 42577314 |
| Impaired quality of life | 16.95 | 14.88 | 23 | 15146 | 14154 | 42592012 |
| Heart rate decreased | 16.87 | 14.88 | 39 | 15130 | 36493 | 42569673 |
| Anaplastic large cell lymphoma T- and null-cell types recurrent | 16.82 | 14.88 | 4 | 15165 | 58 | 42606108 |
| Chest discomfort | 16.49 | 14.88 | 55 | 15114 | 63561 | 42542605 |
| Hypopnoea | 16.44 | 14.88 | 17 | 15152 | 7865 | 42598301 |
| Catarrh | 16.41 | 14.88 | 15 | 15154 | 5971 | 42600195 |
| Burns second degree | 16.18 | 14.88 | 15 | 15154 | 6081 | 42600085 |
| Sleep disorder due to a general medical condition | 16.04 | 14.88 | 25 | 15144 | 17428 | 42588738 |
| Cytomegalovirus viraemia | 15.82 | 14.88 | 19 | 15150 | 10358 | 42595808 |
| Traumatic shock | 15.81 | 14.88 | 3 | 15166 | 13 | 42606153 |
| Hepatic function abnormal | 15.58 | 14.88 | 47 | 15122 | 51520 | 42554646 |
| Myocardial infarction | 15.28 | 14.88 | 13 | 15156 | 123996 | 42482170 |
| Leukaemia recurrent | 15.08 | 14.88 | 9 | 15160 | 1867 | 42604299 |
| MedDRA adverse event term | Likelihood ratio | Likelihood ratio threshold | Patients taking drug having adverse event | Patients taking drug not having adverse event | Patients not taking drug having adverse event | Patients not taking drug not having adverse event |
|---|---|---|---|---|---|---|
| Infusion related reaction | 328.93 | 13.97 | 711 | 65235 | 380451 | 110142902 |
| Rheumatic fever | 245.56 | 13.97 | 333 | 65613 | 122246 | 110401107 |
| X-ray abnormal | 227.92 | 13.97 | 186 | 65760 | 37931 | 110485422 |
| Toxicity to various agents | 216.55 | 13.97 | 19 | 65927 | 480536 | 110042817 |
| Sleep disorder due to general medical condition, insomnia type | 213.11 | 13.97 | 288 | 65658 | 105355 | 110417998 |
| Facet joint syndrome | 207.65 | 13.97 | 272 | 65674 | 96556 | 110426797 |
| Swollen joint count increased | 196.69 | 13.97 | 246 | 65700 | 83415 | 110439938 |
| Porphyria acute | 190.28 | 13.97 | 126 | 65820 | 18654 | 110504699 |
| Sciatica | 177.44 | 13.97 | 246 | 65700 | 92153 | 110431200 |
| Dislocation of vertebra | 173.10 | 13.97 | 169 | 65777 | 43552 | 110479801 |
| Ill-defined disorder | 172.48 | 13.97 | 324 | 65622 | 156529 | 110366824 |
| Type 2 diabetes mellitus | 171.66 | 13.97 | 347 | 65599 | 176885 | 110346468 |
| Drug interaction | 164.90 | 13.97 | 47 | 65899 | 500136 | 110023217 |
| Psoriatic arthropathy | 164.76 | 13.97 | 363 | 65583 | 196398 | 110326955 |
| Liver disorder | 157.85 | 13.97 | 295 | 65651 | 141948 | 110381405 |
| Lip dry | 156.72 | 13.97 | 242 | 65704 | 99841 | 110423512 |
| Fibromyalgia | 155.36 | 13.97 | 326 | 65620 | 170583 | 110352770 |
| Urticaria | 154.34 | 13.97 | 479 | 65467 | 318378 | 110204975 |
| Injury | 154.06 | 13.97 | 332 | 65614 | 176933 | 110346420 |
| Helicobacter infection | 149.40 | 13.97 | 333 | 65613 | 181544 | 110341809 |
| Adjustment disorder with depressed mood | 147.02 | 13.97 | 155 | 65791 | 43728 | 110479625 |
| Joint range of motion decreased | 139.34 | 13.97 | 256 | 65690 | 121576 | 110401777 |
| C-reactive protein abnormal | 134.06 | 13.97 | 261 | 65685 | 129434 | 110393919 |
| Rheumatoid factor positive | 133.74 | 13.97 | 263 | 65683 | 131377 | 110391976 |
| Impaired healing | 126.90 | 13.97 | 328 | 65618 | 196389 | 110326964 |
| Hand deformity | 126.50 | 13.97 | 350 | 65596 | 218156 | 110305197 |
| Fall | 126.02 | 13.97 | 105 | 65841 | 603377 | 109919976 |
| Frequent bowel movements | 123.68 | 13.97 | 181 | 65765 | 71209 | 110452144 |
| Wound | 123.55 | 13.97 | 363 | 65583 | 234074 | 110289279 |
| Road traffic accident | 123.22 | 13.97 | 226 | 65720 | 107172 | 110416181 |
| Folliculitis | 122.31 | 13.97 | 293 | 65653 | 167360 | 110355993 |
| Lower limb fracture | 119.07 | 13.97 | 183 | 65763 | 75165 | 110448188 |
| Systemic lupus erythematosus | 118.34 | 13.97 | 377 | 65569 | 253961 | 110269392 |
| Irritable bowel syndrome | 117.66 | 13.97 | 285 | 65661 | 163930 | 110359423 |
| Wound infection | 117.05 | 13.97 | 208 | 65738 | 96257 | 110427096 |
| Duodenal ulcer perforation | 116.37 | 13.97 | 298 | 65648 | 177402 | 110345951 |
| Glossodynia | 116.27 | 13.97 | 343 | 65603 | 221661 | 110301692 |
| C-reactive protein | 115.88 | 13.97 | 115 | 65831 | 30216 | 110493137 |
| Retinitis | 115.14 | 13.97 | 118 | 65828 | 32209 | 110491144 |
| Lupus-like syndrome | 113.98 | 13.97 | 131 | 65815 | 40661 | 110482692 |
| Acute kidney injury | 113.57 | 13.97 | 127 | 65819 | 635303 | 109888050 |
| Deep vein thrombosis postoperative | 112.52 | 13.97 | 157 | 65789 | 59134 | 110464219 |
| Death | 102.17 | 13.97 | 162 | 65784 | 698707 | 109824646 |
| Inflammation | 101.59 | 13.97 | 299 | 65647 | 192939 | 110330414 |
| Muscle injury | 101.52 | 13.97 | 245 | 65701 | 140562 | 110382791 |
| Dry mouth | 96.29 | 13.97 | 300 | 65646 | 199648 | 110323705 |
| Infection | 95.98 | 13.97 | 449 | 65497 | 361751 | 110161602 |
| Night sweats | 90.10 | 13.97 | 227 | 65719 | 133756 | 110389597 |
| Wheezing | 89.00 | 13.97 | 344 | 65602 | 254886 | 110268467 |
| Nipple swelling | 87.09 | 13.97 | 24 | 65922 | 373 | 110522980 |
| Hypersensitivity | 86.76 | 13.97 | 472 | 65474 | 403526 | 110119827 |
| Sleep disorder | 82.13 | 13.97 | 283 | 65663 | 198361 | 110324992 |
| Synovitis | 81.75 | 13.97 | 352 | 65594 | 273740 | 110249613 |
| Peripheral venous disease | 80.54 | 13.97 | 164 | 65782 | 83953 | 110439400 |
| Grip strength decreased | 79.97 | 13.97 | 159 | 65787 | 80015 | 110443338 |
| Drug ineffective | 79.74 | 13.97 | 556 | 65390 | 1519984 | 109003369 |
| Feeling hot | 78.36 | 13.97 | 170 | 65776 | 90936 | 110432417 |
| Mechanical ventilation complication | 75.36 | 13.97 | 25 | 65921 | 746 | 110522607 |
| Intentional product use issue | 75.18 | 13.97 | 320 | 65626 | 247586 | 110275767 |
| Autoimmune disorder | 74.08 | 13.97 | 137 | 65809 | 65346 | 110458007 |
| Pericarditis | 72.06 | 13.97 | 290 | 65656 | 218824 | 110304529 |
| Stomatitis | 71.53 | 13.97 | 335 | 65611 | 269907 | 110253446 |
| Colitis ulcerative | 70.73 | 13.97 | 148 | 65798 | 77215 | 110446138 |
| Pemphigus | 69.78 | 13.97 | 283 | 65663 | 214287 | 110309066 |
| Lupus vulgaris | 67.70 | 13.97 | 92 | 65854 | 33791 | 110489562 |
| Lung disorder | 67.14 | 13.97 | 248 | 65698 | 179799 | 110343554 |
| Bursitis | 66.32 | 13.97 | 199 | 65747 | 129719 | 110393634 |
| Sinusitis | 65.93 | 13.97 | 350 | 65596 | 296338 | 110227015 |
| Underdose | 63.33 | 13.97 | 126 | 65820 | 63428 | 110459925 |
| Laryngitis | 62.81 | 13.97 | 100 | 65846 | 42311 | 110481042 |
| Discomfort | 61.90 | 13.97 | 273 | 65673 | 214434 | 110308919 |
| Nipple pain | 61.90 | 13.97 | 24 | 65922 | 1132 | 110522221 |
| Weight increased | 59.97 | 13.97 | 442 | 65504 | 419202 | 110104151 |
| Maternal exposure timing unspecified | 59.57 | 13.97 | 68 | 65878 | 20945 | 110502408 |
| Exostosis | 59.50 | 13.97 | 102 | 65844 | 45854 | 110477499 |
| Liver injury | 59.31 | 13.97 | 211 | 65735 | 150202 | 110373151 |
| Anaemia | 59.15 | 13.97 | 151 | 65795 | 546935 | 109976418 |
| Drug tolerance decreased | 58.43 | 13.97 | 77 | 65869 | 27463 | 110495890 |
| Delirium | 58.10 | 13.97 | 195 | 65751 | 134830 | 110388523 |
| Myocardial infarction | 57.98 | 13.97 | 21 | 65925 | 192062 | 110331291 |
| Swelling | 57.94 | 13.97 | 383 | 65563 | 350658 | 110172695 |
| Intentional overdose | 57.59 | 13.97 | 6 | 65940 | 132495 | 110390858 |
| Obesity | 57.26 | 13.97 | 173 | 65773 | 113178 | 110410175 |
| Pulmonary fibrosis | 56.58 | 13.97 | 161 | 65785 | 101881 | 110421472 |
| Prescribed overdose | 56.39 | 13.97 | 146 | 65800 | 87435 | 110435918 |
| Breast cancer stage III | 56.29 | 13.97 | 137 | 65809 | 78980 | 110444373 |
| Walking aid user | 56.15 | 13.97 | 72 | 65874 | 25003 | 110498350 |
| Injection site pain | 54.48 | 13.97 | 19 | 65927 | 177903 | 110345450 |
| Joint dislocation | 52.54 | 13.97 | 82 | 65864 | 34108 | 110489245 |
| Amnesia | 52.42 | 13.97 | 160 | 65786 | 105248 | 110418105 |
| Oedema | 50.29 | 13.97 | 253 | 65693 | 209723 | 110313630 |
| Musculoskeletal stiffness | 49.66 | 13.97 | 311 | 65635 | 279511 | 110243842 |
| Somnolence | 49.26 | 13.97 | 63 | 65883 | 297386 | 110225967 |
| Hypercholesterolaemia | 49.08 | 13.97 | 142 | 65804 | 90695 | 110432658 |
| Disease progression | 47.78 | 13.97 | 45 | 65901 | 243989 | 110279364 |
| Product dose omission issue | 47.48 | 13.97 | 74 | 65872 | 321708 | 110201645 |
| Chronic obstructive pulmonary disease | 47.29 | 13.97 | 5 | 65941 | 109153 | 110414200 |
| Weight fluctuation | 47.11 | 13.97 | 62 | 65884 | 22083 | 110501270 |
| Prescribed underdose | 46.51 | 13.97 | 113 | 65833 | 65061 | 110458292 |
| Hepatic enzyme increased | 45.81 | 13.97 | 338 | 65608 | 320554 | 110202799 |
| Ear infection | 45.02 | 13.97 | 109 | 65837 | 62623 | 110460730 |
| Hypoaesthesia | 44.87 | 13.97 | 331 | 65615 | 313892 | 110209461 |
| Blister | 44.33 | 13.97 | 259 | 65687 | 227117 | 110296236 |
| Musculoskeletal pain | 43.45 | 13.97 | 220 | 65726 | 182803 | 110340550 |
| Foot deformity | 43.44 | 13.97 | 92 | 65854 | 48388 | 110474965 |
| Grip strength | 43.20 | 13.97 | 39 | 65907 | 9102 | 110514251 |
| Medication error | 42.55 | 13.97 | 149 | 65797 | 105217 | 110418136 |
| Hypertension | 42.47 | 13.97 | 478 | 65468 | 509606 | 110013747 |
| Respiratory disorder | 41.90 | 13.97 | 115 | 65831 | 71267 | 110452086 |
| Suicide attempt | 41.70 | 13.97 | 6 | 65940 | 103388 | 110419965 |
| Hip arthroplasty | 41.15 | 13.97 | 98 | 65848 | 55715 | 110467638 |
| Inspiratory capacity decreased | 40.63 | 13.97 | 23 | 65923 | 2572 | 110520781 |
| Constipation | 40.00 | 13.97 | 97 | 65849 | 357689 | 110165664 |
| Bone erosion | 39.26 | 13.97 | 86 | 65860 | 46285 | 110477068 |
| Insomnia | 39.17 | 13.97 | 357 | 65589 | 360233 | 110163120 |
| Subcutaneous drug absorption impaired | 38.83 | 13.97 | 34 | 65912 | 7625 | 110515728 |
| Product use issue | 38.23 | 13.97 | 317 | 65629 | 311378 | 110211975 |
| Breast cancer stage II | 37.08 | 13.97 | 62 | 65884 | 27313 | 110496040 |
| Dehydration | 36.90 | 13.97 | 69 | 65877 | 279442 | 110243911 |
| Blood pressure fluctuation | 36.66 | 13.97 | 113 | 65833 | 74711 | 110448642 |
| General symptom | 36.52 | 13.97 | 35 | 65911 | 8811 | 110514542 |
| Hyponatraemia | 36.13 | 13.97 | 46 | 65900 | 217607 | 110305746 |
| Gastrointestinal disorder | 35.75 | 13.97 | 257 | 65689 | 241695 | 110281658 |
| Swollen joint count | 35.20 | 13.97 | 34 | 65912 | 8640 | 110514713 |
| Lower respiratory tract infection | 34.64 | 13.97 | 256 | 65690 | 242850 | 110280503 |
| Urinary tract infection | 34.50 | 13.97 | 91 | 65855 | 326191 | 110197162 |
| Disseminated intravascular coagulation | 34.31 | 13.97 | 76 | 65870 | 41210 | 110482143 |
| Disability | 33.88 | 13.97 | 63 | 65883 | 30160 | 110493193 |
| Blood cholesterol increased | 33.78 | 13.97 | 207 | 65739 | 184578 | 110338775 |
| Intentional product misuse | 33.14 | 13.97 | 19 | 65927 | 132885 | 110390468 |
| Wrong technique in product usage process | 33.14 | 13.97 | 6 | 65940 | 87342 | 110436011 |
| Mobility decreased | 32.69 | 13.97 | 248 | 65698 | 237174 | 110286179 |
| Malignant neoplasm progression | 32.09 | 13.97 | 34 | 65912 | 174533 | 110348820 |
| Pulmonary embolism | 31.93 | 13.97 | 49 | 65897 | 214425 | 110308928 |
| Atrial fibrillation | 31.82 | 13.97 | 55 | 65891 | 229587 | 110293766 |
| Neuropathy peripheral | 31.76 | 13.97 | 36 | 65910 | 179241 | 110344112 |
| Gait inability | 31.71 | 13.97 | 163 | 65783 | 136213 | 110387140 |
| Anti-cyclic citrullinated peptide antibody positive | 31.48 | 13.97 | 201 | 65745 | 181783 | 110341570 |
| Cerebrovascular accident | 31.47 | 13.97 | 37 | 65909 | 181247 | 110342106 |
| Live birth | 31.35 | 13.97 | 102 | 65844 | 69382 | 110453971 |
| Pyrexia | 31.30 | 13.97 | 728 | 65218 | 897537 | 109625816 |
| Osteoporosis | 30.77 | 13.97 | 118 | 65828 | 87034 | 110436319 |
| Sleep disorder due to a general medical condition | 30.63 | 13.97 | 84 | 65862 | 52028 | 110471325 |
| Overdose | 30.60 | 13.97 | 58 | 65888 | 233736 | 110289617 |
| Suicidal ideation | 30.58 | 13.97 | 9 | 65937 | 93928 | 110429425 |
| Syncope | 29.46 | 13.97 | 47 | 65899 | 202489 | 110320864 |
| Coma | 29.18 | 13.97 | 17 | 65929 | 117852 | 110405501 |
| Haemoglobin decreased | 28.93 | 13.97 | 66 | 65880 | 248661 | 110274692 |
| Adverse event | 28.83 | 13.97 | 135 | 65811 | 108674 | 110414679 |
| Myalgia | 28.38 | 13.97 | 56 | 65890 | 222325 | 110301028 |
| Neutropenia | 28.28 | 13.97 | 121 | 65825 | 374499 | 110148854 |
| Bradycardia | 27.80 | 13.97 | 31 | 65915 | 155486 | 110367867 |
| Rectal haemorrhage | 27.70 | 13.97 | 143 | 65803 | 119690 | 110403663 |
| Hepatic cirrhosis | 27.62 | 13.97 | 96 | 65850 | 67530 | 110455823 |
| Transient ischaemic attack | 27.53 | 13.97 | 3 | 65943 | 63979 | 110459374 |
| Knee arthroplasty | 27.22 | 13.97 | 93 | 65853 | 64855 | 110458498 |
| Transaminases increased | 27.21 | 13.97 | 3 | 65943 | 63387 | 110459966 |
| Cardiac failure congestive | 27.10 | 13.97 | 30 | 65916 | 150970 | 110372383 |
| Osteoarthritis | 25.83 | 13.97 | 192 | 65754 | 182431 | 110340922 |
| Dyspnoea exertional | 25.77 | 13.97 | 15 | 65931 | 104045 | 110419308 |
| Injection site erythema | 25.65 | 13.97 | 12 | 65934 | 94164 | 110429189 |
| Pruritus | 25.30 | 13.97 | 487 | 65459 | 581073 | 109942280 |
| Migraine | 25.15 | 13.97 | 182 | 65764 | 171470 | 110351883 |
| Seronegative arthritis | 25.15 | 13.97 | 35 | 65911 | 13142 | 110510211 |
| Coronary artery disease | 24.98 | 13.97 | 6 | 65940 | 71684 | 110451669 |
| Aggression | 24.92 | 13.97 | 3 | 65943 | 59207 | 110464146 |
| Pregnancy | 24.90 | 13.97 | 77 | 65869 | 50990 | 110472363 |
| Anaphylactic shock | 24.46 | 13.97 | 77 | 65869 | 51469 | 110471884 |
| Nausea | 24.24 | 13.97 | 557 | 65389 | 1235133 | 109288220 |
| Blood glucose increased | 24.13 | 13.97 | 26 | 65920 | 132470 | 110390883 |
| Dysarthria | 24.05 | 13.97 | 10 | 65936 | 84111 | 110439242 |
| Sedation | 23.95 | 13.97 | 6 | 65940 | 69677 | 110453676 |
| Lethargy | 23.88 | 13.97 | 13 | 65933 | 93563 | 110429790 |
| Cardiac arrest | 23.87 | 13.97 | 51 | 65895 | 196702 | 110326651 |
| Haemothorax | 23.83 | 13.97 | 25 | 65921 | 7006 | 110516347 |
| Contusion | 23.79 | 13.97 | 228 | 65718 | 233133 | 110290220 |
| Rash vesicular | 23.72 | 13.97 | 36 | 65910 | 14616 | 110508737 |
| Rash | 23.44 | 13.97 | 648 | 65298 | 820316 | 109703037 |
| Cough | 23.43 | 13.97 | 170 | 65776 | 461471 | 110061882 |
| Pancreatitis | 23.30 | 13.97 | 114 | 65832 | 93419 | 110429934 |
| Ear pain | 23.00 | 13.97 | 77 | 65869 | 53149 | 110470204 |
| Red blood cell sedimentation rate increased | 22.87 | 13.97 | 100 | 65846 | 78202 | 110445151 |
| Pustular psoriasis | 22.84 | 13.97 | 34 | 65912 | 13571 | 110509782 |
| Gastrointestinal haemorrhage | 22.60 | 13.97 | 40 | 65906 | 165478 | 110357875 |
| Cognitive disorder | 22.56 | 13.97 | 12 | 65934 | 87499 | 110435854 |
| Thrombosis | 22.50 | 13.97 | 19 | 65927 | 108643 | 110414710 |
| Seizure | 22.38 | 13.97 | 63 | 65883 | 221122 | 110302231 |
| Balance disorder | 22.22 | 13.97 | 22 | 65924 | 116538 | 110406815 |
| Orthostatic hypotension | 22.21 | 13.97 | 6 | 65940 | 66243 | 110457110 |
| Hallucination | 21.92 | 13.97 | 17 | 65929 | 101415 | 110421938 |
| Cerebellar tumour | 21.87 | 13.97 | 7 | 65939 | 186 | 110523167 |
| Rheumatoid arthritis | 21.86 | 13.97 | 98 | 65848 | 299515 | 110223838 |
| Electrocardiogram QT prolonged | 21.43 | 13.97 | 20 | 65926 | 108940 | 110414413 |
| Lactic acidosis | 20.77 | 13.97 | 15 | 65931 | 92796 | 110430557 |
| Ascites | 20.77 | 13.97 | 15 | 65931 | 92793 | 110430560 |
| Pain in jaw | 20.56 | 13.97 | 3 | 65943 | 51174 | 110472179 |
| Renal failure | 20.46 | 13.97 | 68 | 65878 | 226506 | 110296847 |
| Anti-cyclic citrullinated peptide antibody | 20.39 | 13.97 | 40 | 65906 | 19924 | 110503429 |
| Therapy non-responder | 20.35 | 13.97 | 162 | 65784 | 157145 | 110366208 |
| Flushing | 20.20 | 13.97 | 119 | 65827 | 104617 | 110418736 |
| Injection site swelling | 19.96 | 13.97 | 6 | 65940 | 61784 | 110461569 |
| White blood cell count increased | 19.96 | 13.97 | 112 | 65834 | 96730 | 110426623 |
| Diverticulitis | 19.62 | 13.97 | 4 | 65942 | 53518 | 110469835 |
| Cholestasis | 19.55 | 13.97 | 7 | 65939 | 64511 | 110458842 |
| International normalised ratio increased | 19.45 | 13.97 | 14 | 65932 | 86758 | 110436595 |
| Drug resistance | 19.10 | 13.97 | 5 | 65941 | 56369 | 110466984 |
| Anaphylactic reaction | 18.99 | 13.97 | 125 | 65821 | 114175 | 110409178 |
| Joint swelling | 18.95 | 13.97 | 370 | 65576 | 442475 | 110080878 |
| Chronic kidney disease | 18.89 | 13.97 | 11 | 65935 | 76280 | 110447073 |
| Cardiac disorder | 18.88 | 13.97 | 11 | 65935 | 76269 | 110447084 |
| Influenza like illness | 18.88 | 13.97 | 15 | 65931 | 88397 | 110434956 |
| Osteonecrosis of jaw | 18.87 | 13.97 | 3 | 65943 | 48014 | 110475339 |
| Mental status changes | 18.81 | 13.97 | 11 | 65935 | 76111 | 110447242 |
| Metabolic acidosis | 18.81 | 13.97 | 19 | 65927 | 99725 | 110423628 |
| Cardio-respiratory arrest | 18.68 | 13.97 | 25 | 65921 | 115811 | 110407542 |
| Cytomegalovirus viraemia | 18.64 | 13.97 | 36 | 65910 | 17728 | 110505625 |
| Therapeutic product effect decreased | 18.53 | 13.97 | 225 | 65721 | 244091 | 110279262 |
| Angioedema | 18.31 | 13.97 | 19 | 65927 | 98481 | 110424872 |
| Acute myocardial infarction | 18.16 | 13.97 | 14 | 65932 | 83763 | 110439590 |
| Myoglobinaemia | 17.99 | 13.97 | 6 | 65940 | 182 | 110523171 |
| Cardiac failure | 17.85 | 13.97 | 55 | 65891 | 187571 | 110335782 |
| Abdominal discomfort | 17.85 | 13.97 | 332 | 65614 | 393526 | 110129827 |
| Hypoglycaemia | 17.78 | 13.97 | 26 | 65920 | 116078 | 110407275 |
| Skin ulcer | 17.50 | 13.97 | 8 | 65938 | 63637 | 110459716 |
| Joint stiffness | 17.50 | 13.97 | 83 | 65863 | 67160 | 110456193 |
| Drug reaction with eosinophilia and systemic symptoms | 17.44 | 13.97 | 14 | 65932 | 82081 | 110441272 |
| Hepatotoxicity | 17.39 | 13.97 | 8 | 65938 | 63392 | 110459961 |
| Adverse drug reaction | 17.27 | 13.97 | 115 | 65831 | 105444 | 110417909 |
| Adrenal insufficiency | 17.15 | 13.97 | 60 | 65886 | 42330 | 110481023 |
| Throat irritation | 16.88 | 13.97 | 70 | 65876 | 53482 | 110469871 |
| Irritability | 16.66 | 13.97 | 4 | 65942 | 47805 | 110475548 |
| Injection site bruising | 16.52 | 13.97 | 5 | 65941 | 51258 | 110472095 |
| Muscle spasms | 16.48 | 13.97 | 245 | 65701 | 277912 | 110245441 |
| Feeling abnormal | 16.47 | 13.97 | 54 | 65892 | 180657 | 110342696 |
| Polyglandular disorder | 16.41 | 13.97 | 6 | 65940 | 240 | 110523113 |
| Angiopathy | 16.38 | 13.97 | 23 | 65923 | 8707 | 110514646 |
| Middle ear inflammation | 16.25 | 13.97 | 6 | 65940 | 247 | 110523106 |
| Oropharyngeal discomfort | 16.19 | 13.97 | 25 | 65921 | 10302 | 110513051 |
| Interstitial lung disease | 16.17 | 13.97 | 37 | 65909 | 139297 | 110384056 |
| Dysphagia | 16.10 | 13.97 | 43 | 65903 | 153557 | 110369796 |
| Hepatitis | 16.04 | 13.97 | 18 | 65928 | 90036 | 110433317 |
| Hypotension | 16.03 | 13.97 | 218 | 65728 | 523631 | 109999722 |
| Accidental exposure to product | 15.90 | 13.97 | 5 | 65941 | 50003 | 110473350 |
| Obstructive airways disorder | 15.81 | 13.97 | 4 | 65942 | 46145 | 110477208 |
| Liver function test abnormal | 15.62 | 13.97 | 11 | 65935 | 68939 | 110454414 |
| External ear cellulitis | 15.62 | 13.97 | 6 | 65940 | 276 | 110523077 |
| Angina pectoris | 15.39 | 13.97 | 9 | 65937 | 62286 | 110461067 |
| Antithrombin III decreased | 15.13 | 13.97 | 7 | 65939 | 513 | 110522840 |
| Arthropathy | 15.04 | 13.97 | 248 | 65698 | 287274 | 110236079 |
| Visual impairment | 15.03 | 13.97 | 134 | 65812 | 134294 | 110389059 |
| Laboratory test abnormal | 15.00 | 13.97 | 59 | 65887 | 44020 | 110479333 |
| Enterococcus test positive | 14.94 | 13.97 | 13 | 65933 | 2891 | 110520462 |
| Gastrooesophageal reflux disease | 14.92 | 13.97 | 56 | 65890 | 179920 | 110343433 |
| Apocrine miliaria | 14.88 | 13.97 | 3 | 65943 | 10 | 110523343 |
| Exposure during pregnancy | 14.86 | 13.97 | 159 | 65787 | 167265 | 110356088 |
| Generalised tonic-clonic seizure | 14.84 | 13.97 | 7 | 65939 | 54673 | 110468680 |
| Unresponsive to stimuli | 14.69 | 13.97 | 10 | 65936 | 63780 | 110459573 |
| Onychomadesis | 14.64 | 13.97 | 60 | 65886 | 45603 | 110477750 |
| Arrhythmia | 14.61 | 13.97 | 12 | 65934 | 69563 | 110453790 |
| Hepatocellular injury | 14.51 | 13.97 | 6 | 65940 | 50636 | 110472717 |
| Anaplastic large cell lymphoma T- and null-cell types recurrent | 14.35 | 13.97 | 4 | 65942 | 65 | 110523288 |
| Hypercalcaemia | 14.24 | 13.97 | 5 | 65941 | 46652 | 110476701 |
| Rash maculo-papular | 14.15 | 13.97 | 14 | 65932 | 74208 | 110449145 |
| Pituitary tumour recurrent | 14.10 | 13.97 | 5 | 65941 | 183 | 110523170 |
| Polyp | 14.05 | 13.97 | 23 | 65923 | 9957 | 110513396 |
None
| Source | Code | Description |
|---|---|---|
| FDA MoA | N0000175450 | Corticosteroid Hormone Receptor Agonists |
| FDA EPC | N0000175576 | Corticosteroid |
| MeSH PA | D000893 | Anti-Inflammatory Agents |
| CHEBI has role | CHEBI:35610 | antineoplastic agent |
| CHEBI has role | CHEBI:65023 | anti-asthmatic agent |
| Disease | Relation | SNOMED_ID | DOID |
|---|---|---|---|
| Disorder of musculoskeletal system | indication | 928000 | DOID:17 |
| Cerebral edema | indication | 2032001 | |
| Berylliosis | indication | 8247009 | DOID:10322 |
| Psoriasis | indication | 9014002 | DOID:8893 |
| Ankylosing spondylitis | indication | 9631008 | DOID:7147 |
| Rheumatic heart disease | indication | 23685000 | |
| Atopic dermatitis | indication | 24079001 | DOID:3310 |
| Inflammatory bowel disease | indication | 24526004 | DOID:0050589 |
| Multiple sclerosis | indication | 24700007 | DOID:2377 |
| Severe adrenal insufficiency | indication | 24867002 | |
| Sarcoidosis | indication | 31541009 | DOID:11335 |
| Idiopathic thrombocytopenic purpura | indication | 32273002 | DOID:8924 |
| Psoriasis with arthropathy | indication | 33339001 | |
| Crohn's disease | indication | 34000006 | |
| Tendinitis | indication | 34840004 | DOID:971 |
| Erythema multiforme | indication | 36715001 | |
| Contact dermatitis | indication | 40275004 | DOID:2773 |
| Angioedema | indication | 41291007 | DOID:1558 |
| Humoral hypercalcemia of malignancy | indication | 47709007 | |
| Articular gout | indication | 48440001 | DOID:13189 |
| Edema of larynx | indication | 51599000 | |
| Nephrotic syndrome | indication | 52254009 | DOID:1184 |
| Systemic lupus erythematosus | indication | 55464009 | DOID:9074 |
| Allergic rhinitis | indication | 61582004 | |
| Lรถffler's syndrome | indication | 64936001 | DOID:9503 |
| Pemphigus | indication | 65172003 | DOID:9182 |
| Tenosynovitis | indication | 67801009 | DOID:970 |
| Rheumatoid arthritis | indication | 69896004 | DOID:7148 |
| Transfusion reaction due to serum protein reaction | indication | 72284000 | |
| Acquired thrombocytopenia | indication | 74576004 | DOID:11126 |
| Thyroiditis | indication | 82119001 | DOID:7166 |
| Bursitis | indication | 84017003 | DOID:2965 |
| Autoimmune disease | indication | 85828009 | |
| Infection by larvae of Trichinella spiralis | indication | 88264003 | |
| Congenital hypoplastic anemia | indication | 88854002 | DOID:1339 |
| Acute lymphoid leukemia | indication | 91857003 | DOID:9952 |
| Dermatitis herpetiformis | indication | 111196000 | DOID:8505 |
| Hodgkin's disease | indication | 118599009 | |
| Non-Hodgkin's lymphoma | indication | 118601006 | |
| Mycosis fungoides | indication | 118618005 | |
| Aspiration pneumonitis | indication | 155597006 | |
| Asthma | indication | 195967001 | DOID:2841 |
| Transplanted organ rejection | indication | 213148006 | |
| Adrenogenital disorder | indication | 267395000 | DOID:0050811 |
| Eruption of skin | indication | 271807003 | DOID:0050486 |
| Disorder of eye | indication | 371405004 | DOID:5614 |
| Primary adrenocortical insufficiency | indication | 373662000 | |
| Adrenal cortical hypofunction | indication | 386584007 | DOID:10493 |
| Erythroderma | indication | 399992009 | |
| Autoimmune hemolytic anemia | indication | 413603009 | DOID:718 |
| Synovitis | indication | 416209007 | DOID:2703 |
| Post traumatic osteoarthritis | indication | 699262001 | |
| Erythroblastic Anemia | indication | ||
| Diagnostic Test for Cushing's Syndrome | indication | ||
| Transfusion Reaction Urticaria | indication | ||
| Systemic Dermatomyositis | indication | ||
| Synovitis due to Osteoarthritis | indication | ||
| Respiratory distress syndrome in the newborn | off-label use | 46775006 | |
| Neonatal Bronchopulmonary Dysplasia | off-label use | ||
| Mycosis | contraindication | 3218000 | DOID:1564 |
| Ocular hypertension | contraindication | 4210003 | DOID:9282 |
| Inactive tuberculosis | contraindication | 11999007 | |
| Peptic ulcer | contraindication | 13200003 | DOID:750 |
| Measles | contraindication | 14189004 | DOID:8622 |
| Esophagitis | contraindication | 16761005 | DOID:11963 |
| Mood swings | contraindication | 18963009 | |
| Cirrhosis of liver | contraindication | 19943007 | DOID:5082 |
| Glaucoma | contraindication | 23986001 | DOID:1686 |
| Abscess of intestine | contraindication | 24557004 | |
| Hypertensive disorder | contraindication | 38341003 | DOID:10763 |
| Infectious disease | contraindication | 40733004 | |
| Hypothyroidism | contraindication | 40930008 | DOID:1459 |
| Hypokalemia | contraindication | 43339004 | |
| Chronic heart failure | contraindication | 48447003 | |
| Duodenal ulcer disease | contraindication | 51868009 | DOID:1724 |
| Osteoporosis | contraindication | 64859006 | DOID:11476 |
| Psychotic disorder | contraindication | 69322001 | |
| Diabetes mellitus | contraindication | 73211009 | DOID:9351 |
| Hypopituitarism | contraindication | 74728003 | DOID:9406 |
| Hyperglycemia | contraindication | 80394007 | DOID:4195 |
| Kidney disease | contraindication | 90708001 | DOID:557 |
| Bilateral cataracts | contraindication | 95722004 | |
| Eye infection | contraindication | 128351009 | |
| Disorder of muscle | contraindication | 129565002 | DOID:423 |
| Anastomosis of intestine | contraindication | 235407009 | |
| Diverticulitis of gastrointestinal tract | contraindication | 271366000 | |
| Varicella-zoster virus infection | contraindication | 309465005 | |
| Viral eye infection | contraindication | 312132001 | |
| Gastric ulcer | contraindication | 397825006 | DOID:10808 |
| Exposure to varicella | contraindication | 444453009 |
None
None
| Dissociation level | Dissociation constant | Type (acidic/basic) |
|---|---|---|
| pKa1 | 4.23 | acidic |
| pKa2 | 12.94 | acidic |
None
None
| Target | Class | Pharos | UniProt | Action | Type | Activity value (-log[M]) | Mechanism action | Bioact source | MoA source |
|---|---|---|---|---|---|---|---|---|---|
| Glucocorticoid receptor | Nuclear hormone receptor | AGONIST | CHEMBL | CHEMBL | |||||
| Glucocorticoid receptor | Transcription factor | Kd | 6.72 | CHEMBL |
| ID | Source |
|---|---|
| D00978 | KEGG_DRUG |
| 4017945 | VUID |
| N0000146295 | NUI |
| 4017941 | VANDF |
| 4017945 | VANDF |
| CHEBI:31677 | CHEBI |
| CHEMBL3989663 | ChEMBL_ID |
| CHEMBL1200495 | ChEMBL_ID |
| DB14545 | DRUGBANK_ID |
| C007133 | MESH_SUPPLEMENTAL_RECORD_UI |
| 16623 | PUBCHEM_CID |
| DB00741 | DRUGBANK_ID |
| 21651 | RXNORM |
| 20708 | MMSL |
| 2500 | MMSL |
| 41706 | MMSL |
| 4837 | MMSL |
| 4843 | MMSL |
| 73114 | MMSL |
| d00254 | MMSL |
| 002147 | NDDF |
| 002152 | NDDF |
| 005251 | NDDF |
| 109066000 | SNOMEDCT_US |
| 16602005 | SNOMEDCT_US |
| 396458002 | SNOMEDCT_US |
| 56423005 | SNOMEDCT_US |
| C0056387 | UMLSCUI |
| C0020268 | UMLSCUI |
| 83784-20-7 | SECONDARY_CAS_RN |
| 5754 | PUBCHEM_CID |
| 38 | INN_ID |
| D006854 | MESH_DESCRIPTOR_UI |
| 50LQB69S1Z | UNII |
| CHEBI:17650 | CHEBI |
| 50LQB69S1Z | INXIGHT DRUGS |
| Product | Category | Ingredients | NDC | Form | Quantity | Route | Marketing | Label |
|---|---|---|---|---|---|---|---|---|
| Solu-Cortef | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0009-0005 | INJECTION, POWDER, FOR SOLUTION | 1000 mg | INTRAMUSCULAR | NDA | 22 sections |
| Solu-Cortef | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0009-0011 | INJECTION, POWDER, FOR SOLUTION | 100 mg | INTRAMUSCULAR | NDA | 22 sections |
| Solu-Cortef | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0009-0013 | INJECTION, POWDER, FOR SOLUTION | 250 mg | INTRAMUSCULAR | NDA | 22 sections |
| Solu-Cortef | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0009-0016 | INJECTION, POWDER, FOR SOLUTION | 500 mg | INTRAMUSCULAR | NDA | 22 sections |
| Solu-Cortef | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0009-0825 | INJECTION, POWDER, FOR SOLUTION | 100 mg | INTRAMUSCULAR | NDA | 22 sections |
| SOLU-CORTEF | HUMAN PRESCRIPTION DRUG LABEL | 1 | 51662-1261 | INJECTION, POWDER, FOR SOLUTION | 100 mg | INTRAMUSCULAR | NDA | 13 sections |
| SOLU-CORTEF | HUMAN PRESCRIPTION DRUG LABEL | 1 | 51662-1262 | INJECTION, POWDER, FOR SOLUTION | 250 mg | INTRAMUSCULAR | NDA | 13 sections |
| Solu-Cortef | HUMAN PRESCRIPTION DRUG LABEL | 1 | 55154-3942 | INJECTION, POWDER, FOR SOLUTION | 100 mg | INTRAMUSCULAR | NDA | 22 sections |
| Hydrocortisone sodium succinate | HUMAN PRESCRIPTION DRUG LABEL | 1 | 60505-6411 | INJECTION, POWDER, FOR SOLUTION | 100 mg | INTRAMUSCULAR | ANDA | 21 sections |
| Hydrocortisone sodium succinate | HUMAN PRESCRIPTION DRUG LABEL | 1 | 69097-004 | INJECTION | 100 mg | INTRAMUSCULAR | ANDA | 11 sections |
| Hydrocortisone sodium succinate | HUMAN PRESCRIPTION DRUG LABEL | 1 | 70710-1907 | INJECTION | 100 mg | INTRAMUSCULAR | ANDA | 12 sections |
| Hydrocortisone sodium succinate | HUMAN PRESCRIPTION DRUG LABEL | 1 | 70771-1966 | INJECTION | 100 mg | INTRAMUSCULAR | ANDA | 1 sections |
| Solu-Cortef | HUMAN PRESCRIPTION DRUG LABEL | 1 | 84549-011 | INJECTION, POWDER, FOR SOLUTION | 100 mg | INTRAMUSCULAR | NDA | 22 sections |