hydrocortisone succinate 🐶 Veterinary Use | Indications/Contra | FAERs-F | FAERs-M | Orange Bk | BioActivity |

Stem definition	Drug id	CAS RN
corticosteroids, except prednisolone derivatives	4456	125-04-2

Description:

Molecule	Description
Molfile Inchi Smiles Synonyms: hydrocortisone sodium succinate hydrocortisone succinate hydrocortisone hemisuccinate	Molecular weight: 462.54 Formula: C25H34O8 CLOGP: 2.19 LIPINSKI: 0 HAC: 8 HDO: 3 TPSA: 138.20 ALOGS: -3.85 ROTB: 7 Status: OFP Legend: OFP - off patent OFM - off market ONP - on patent

Molecule

Description

Molfile Inchi Smiles

Synonyms:

hydrocortisone sodium succinate
hydrocortisone succinate
hydrocortisone hemisuccinate

Molecular weight: 462.54
Formula: C25H34O8
CLOGP: 2.19
LIPINSKI: 0
HAC: 8
HDO: 3
TPSA: 138.20
ALOGS: -3.85
ROTB: 7

Status: OFP

Legend:
OFP - off patent
OFM - off market
ONP - on patent

Drug dosage:

None

ADMET properties:

Property	Value	Reference
S (Water solubility)	0.23 mg/mL	Bocci G, Oprea TI, Benet LZ

Approvals:

Date	Agency	Company	Orphan
April 27, 1955	FDA	PHARMACIA AND UPJOHN

FDA Adverse Event Reporting System (Female)

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MedDRA adverse event term	Likelihood ratio	Likelihood ratio threshold	Patients taking drug having adverse event	Patients taking drug not having adverse event	Patients not taking drug having adverse event	Patients not taking drug not having adverse event
Infusion related reaction	253.95	13.56	351	20028	245170	63223473
Flushing	85.89	13.56	113	20266	74974	63393669
Urticaria	65.25	13.56	156	20223	165646	63302997
Toxicity to various agents	60.68	13.56	5	20374	247245	63221398
Intentional product use issue	44.65	13.56	115	20264	127777	63340866
Drug ineffective	41.48	13.56	184	20195	1044581	62424062
Blood pressure fluctuation	38.63	13.56	60	20319	46257	63422386
Off label use	37.54	13.56	355	20024	674107	62794536
Drug interaction	36.41	13.56	14	20365	229117	63239526
Febrile neutropenia	35.80	13.56	101	20278	118348	63350295

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FDA Adverse Event Reporting System (Male)

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MedDRA adverse event term	Likelihood ratio	Likelihood ratio threshold	Patients taking drug having adverse event	Patients taking drug not having adverse event	Patients not taking drug having adverse event	Patients not taking drug not having adverse event
Infusion related reaction	308.22	15.12	203	11661	52854	34892213
Nipple swelling	78.84	15.12	19	11845	308	34944759
Nipple pain	63.16	15.12	20	11844	917	34944150
Disseminated intravascular coagulation	56.85	15.12	52	11812	21764	34923303
Pyrexia	54.45	15.12	240	11624	332773	34612294
Flushing	52.88	15.12	60	11804	32360	34912707
Off label use	47.82	15.12	273	11591	419251	34525816
Febrile neutropenia	41.54	15.12	121	11743	136728	34808339
Platelet count decreased	35.50	15.12	105	11759	119612	34825455
Urticaria	32.61	15.12	68	11796	62309	34882758

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FDA Adverse Event Reporting System (Geriatric)

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MedDRA adverse event term	Likelihood ratio	Likelihood ratio threshold	Patients taking drug having adverse event	Patients taking drug not having adverse event	Patients not taking drug having adverse event	Patients not taking drug not having adverse event
Infusion related reaction	284.04	12.79	371	26933	229866	79487218
Off label use	98.63	12.79	587	26717	906628	78810456
Toxicity to various agents	89.16	12.79	18	27286	421522	79295562
Nipple swelling	79.02	12.79	19	27285	302	79716782
Urticaria	75.69	12.79	184	27120	185017	79532067
Blood pressure fluctuation	68.64	12.79	99	27205	67046	79650038
Intentional product use issue	65.23	12.79	154	27150	151958	79565126
Flushing	59.88	12.79	108	27196	88160	79628924
Nipple pain	59.09	12.79	19	27285	907	79716177
Disseminated intravascular coagulation	59.05	12.79	67	27237	35775	79681309

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FDA Adverse Event Reporting System (Pediatric)

None

Pharmacologic Action:

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Source	Code	Description
CHEBI has role	CHEBI:35472	anti-inflammatory drugs
CHEBI has role	CHEBI:49167	anti-asthmatic drugs
CHEBI has role	CHEBI:50857	anti-allergic drugs
CHEBI has role	CHEBI:75771	Mus musculus metabolites
CHEBI has role	CHEBI:77746	Homo sapiens metabolite
CHEBI has role	CHEBI:88188	allergenic drug
FDA EPC	N0000175576	Corticosteroid
FDA MoA	N0000175450	Corticosteroid Hormone Receptor Agonists
MeSH PA	D000893	Anti-Inflammatory Agents

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Drug Use | Suggest Off label Use Form| |View source of the data|

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Disease	Relation	SNOMED_ID	DOID
Disorder of musculoskeletal system	indication	928000	DOID:17
Cerebral edema	indication	2032001
Berylliosis	indication	8247009	DOID:10322
Psoriasis	indication	9014002	DOID:8893
Ankylosing spondylitis	indication	9631008	DOID:7147
Rheumatic heart disease	indication	23685000
Atopic dermatitis	indication	24079001	DOID:3310
Inflammatory bowel disease	indication	24526004	DOID:0050589
Multiple sclerosis	indication	24700007	DOID:2377
Severe adrenal insufficiency	indication	24867002

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🐶 Veterinary Drug Use

None

🐶 Veterinary products

None

Acid dissociation constants calculated using MoKa v3.0.0

Dissociation level	Dissociation constant	Type (acidic/basic)
pKa1	4.23	acidic
pKa2	12.94	acidic

Orange Book patent data (new drug applications)

None

Orange Book exclusivity data (new drug applications)

None

Bioactivity Summary:

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Target	Class	Pharos	UniProt	Action	Type	Activity value (-log[M])	Mechanism action	Bioact source	MoA source
Glucocorticoid receptor	Nuclear hormone receptor	P04150	GCR_HUMAN	AGONIST				CHEMBL	CHEMBL
Glucocorticoid receptor	Transcription factor		GCR_MOUSE		Kd	6.72		CHEMBL

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External reference:

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ID	Source
002147	NDDF
002152	NDDF
005251	NDDF
109066000	SNOMEDCT_US
16602005	SNOMEDCT_US
16623	PUBCHEM_CID
20708	MMSL
21651	RXNORM
2500	MMSL
38	INN_ID

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Pharmaceutical products:

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Product	Category	Ingredients	NDC	Form	Quantity	Route	Marketing	Label
Solu-Cortef	HUMAN PRESCRIPTION DRUG LABEL	1	0009-0005	INJECTION, POWDER, FOR SOLUTION	1000 mg	INTRAMUSCULAR	NDA	22 sections
Solu-Cortef	HUMAN PRESCRIPTION DRUG LABEL	1	0009-0011	INJECTION, POWDER, FOR SOLUTION	100 mg	INTRAMUSCULAR	NDA	22 sections
Solu-Cortef	HUMAN PRESCRIPTION DRUG LABEL	1	0009-0013	INJECTION, POWDER, FOR SOLUTION	250 mg	INTRAMUSCULAR	NDA	22 sections
Solu-Cortef	HUMAN PRESCRIPTION DRUG LABEL	1	0009-0016	INJECTION, POWDER, FOR SOLUTION	500 mg	INTRAMUSCULAR	NDA	22 sections
Solu-Cortef	HUMAN PRESCRIPTION DRUG LABEL	1	0009-0825	INJECTION, POWDER, FOR SOLUTION	100 mg	INTRAMUSCULAR	NDA	22 sections
SOLU-CORTEF	HUMAN PRESCRIPTION DRUG LABEL	1	51662-1261	INJECTION, POWDER, FOR SOLUTION	100 mg	INTRAMUSCULAR	NDA	13 sections
SOLU-CORTEF	HUMAN PRESCRIPTION DRUG LABEL	1	51662-1261	INJECTION, POWDER, FOR SOLUTION	100 mg	INTRAMUSCULAR	NDA	13 sections
SOLU-CORTEF	HUMAN PRESCRIPTION DRUG LABEL	1	51662-1262	INJECTION, POWDER, FOR SOLUTION	250 mg	INTRAMUSCULAR	NDA	13 sections
SOLU-CORTEF	HUMAN PRESCRIPTION DRUG LABEL	1	51662-1262	INJECTION, POWDER, FOR SOLUTION	250 mg	INTRAMUSCULAR	NDA	13 sections
Solu-Cortef	HUMAN PRESCRIPTION DRUG LABEL	1	55154-3942	INJECTION, POWDER, FOR SOLUTION	100 mg	INTRAMUSCULAR	NDA	22 sections

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