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calcitonin human 🐶 Veterinary Use | Indications/Contra | FAERs-F | FAERs-M | Orange Bk | PK/Tox | Related Drugs | BioActivity |
| Stem definition | Drug id | CAS RN |
|---|---|---|
| Vitamin D analogues/derivatives | 4427 | 21215-62-3 |
Description:
| Molecule | Description |
|---|---|
|
Synonyms:
|
|
Drug dosage:
| Dose | Unit | Route |
|---|---|---|
| 100 | U | P |
ADMET properties:
| Property | Value | Reference |
|---|---|---|
| Vd (Volume of distribution) | 0.23 L/kg | Lombardo F, Berellini G, Obach RS |
| CL (Clearance) | 10 mL/min/kg | Lombardo F, Berellini G, Obach RS |
| t_half (Half-life) | 0.82 hours | Lombardo F, Berellini G, Obach RS |
Predicted pharmacokinetic/toxicological properties (PK-AZ):
None
Approvals:
| Date | Agency | Company | Orphan |
|---|---|---|---|
| Oct. 31, 1986 | FDA | NOVARTIS |
FDA Adverse Event Reporting System (Female)
None
FDA Adverse Event Reporting System (Male)
None
FDA Adverse Event Reporting System (Geriatric)
None
FDA Adverse Event Reporting System (Pediatric)
None
Pharmacologic Action:
| Source | Code | Description |
|---|---|---|
| ATC | H05BA03 | SYSTEMIC HORMONAL PREPARATIONS, EXCL. SEX HORMONES AND INSULINS CALCIUM HOMEOSTASIS ANTI-PARATHYROID AGENTS Calcitonin preparations |
| CHEBI has role | CHEBI:25212 | metabolites |
| CHEBI has role | CHEBI:50646 | antiosteoporotic |
Related Drugs by ATC class:
H05BA Calcitonin preparations 3 drugs
Drug Use | Suggest Off label Use Form| |View source of the data|
None
🐶 Veterinary Drug Use
None
🐶 Veterinary products
None
Acid dissociation constants calculated using MoKa v3.0.0
| Dissociation level | Dissociation constant | Type (acidic/basic) |
|---|---|---|
| pKa1 | 3.79 | acidic |
| pKa2 | 9.65 | acidic |
| pKa3 | 11.96 | acidic |
| pKa4 | 12.29 | acidic |
| pKa5 | 12.42 | acidic |
| pKa6 | 12.62 | acidic |
| pKa7 | 12.8 | acidic |
| pKa8 | 12.81 | acidic |
| pKa9 | 12.86 | acidic |
| pKa10 | 12.98 | acidic |
| pKa11 | 13.17 | acidic |
| pKa12 | 13.29 | acidic |
| pKa13 | 13.33 | acidic |
| pKa14 | 13.41 | acidic |
| pKa15 | 13.41 | acidic |
| pKa16 | 13.46 | acidic |
| pKa17 | 13.67 | acidic |
| pKa18 | 13.68 | acidic |
| pKa19 | 13.78 | acidic |
| pKa20 | 13.86 | acidic |
| pKa21 | 13.97 | acidic |
| pKa22 | 10.81 | Basic |
| pKa23 | 7.14 | Basic |
| pKa24 | 6.5 | Basic |
Orange Book patent data (new drug applications)
None
Orange Book exclusivity data (new drug applications)
None
Bioactivity Summary:
| Target | Class | Pharos | UniProt | Action | Type | Activity value (-log[M]) | Mechanism action | Bioact source | MoA source |
|---|---|---|---|---|---|---|---|---|---|
| Calcitonin receptor | GPCR | AGONIST | IC50 | 7.81 | SCIENTIFIC LITERATURE | CHEMBL | |||
| Amylin receptor AMY1 | GPCR | AGONIST | IC50 | 7.53 | SCIENTIFIC LITERATURE | ||||
| Amylin receptor AMY2 | GPCR | AGONIST | IC50 | 8.08 | SCIENTIFIC LITERATURE | ||||
| Amylin receptor AMY3 | GPCR | AGONIST | IC50 | 7.71 | SCIENTIFIC LITERATURE |
External reference:
| ID | Source |
|---|---|
| C0770558 | UMLSCUI |
| CHEBI:135973 | CHEBI |
| CHEMBL4594248 | ChEMBL_ID |
| DB06773 | DRUGBANK_ID |
| I0IO929019 | UNII |
| 45055432 | PUBCHEM_CID |
| 235481 | RXNORM |
| 002145 | NDDF |
| 127383000 | SNOMEDCT_US |
Pharmaceutical products:
None