candicidin 🐶 Veterinary Use | Indications/Contra | FAERs-F | FAERs-M | Orange Bk | BioActivity |
| Stem definition | Drug id | CAS RN |
|---|---|---|
| antibiotics, polyene derivatives | 4424 | 1403-17-4 |
Description:
| Molecule | Description |
|---|---|
|
Synonyms:
|
Mixture of antifungal heptaene macrolides from Streptomyces griseus or Actinomyces levoris used topically in candidiasis. The antibiotic complex is composed of candicidins A, B, C, and D, of which D is the major component.
Legend: OFP - off patent OFM - off market ONP - on patent |
Drug dosage:
| Dose | Unit | Route |
|---|---|---|
| 6 | mg | V |
ADMET properties:
None
Approvals:
| Date | Agency | Company | Orphan |
|---|---|---|---|
| None | FDA | SANOFI AVENTIS US |
FDA Adverse Event Reporting System (Female)
None
FDA Adverse Event Reporting System (Male)
None
FDA Adverse Event Reporting System (Geriatric)
None
FDA Adverse Event Reporting System (Pediatric)
None
Pharmacologic Action:
| Source | Code | Description |
|---|---|---|
| ATC | G01AA04 | GENITO URINARY SYSTEM AND SEX HORMONES GYNECOLOGICAL ANTIINFECTIVES AND ANTISEPTICS ANTIINFECTIVES AND ANTISEPTICS, EXCL. COMBINATIONS WITH CORTICOSTEROIDS Antibiotics |
| CHEBI has role | CHEBI:86327 | pharmaceutical fungicide |
| MeSH PA | D000900 | Anti-Bacterial Agents |
| MeSH PA | D000890 | Anti-Infective Agents |
| MeSH PA | D000935 | Antifungal Agents |
Drug Use | Suggest Off label Use Form| |View source of the data|
| Disease | Relation | SNOMED_ID | DOID |
|---|---|---|---|
| Candidiasis of vagina | indication | 72934000 |
🐶 Veterinary Drug Use
None
🐶 Veterinary products
None
Acid dissociation constants calculated using MoKa v3.0.0
| Dissociation level | Dissociation constant | Type (acidic/basic) |
|---|---|---|
| pKa1 | 4.46 | acidic |
| pKa2 | 10.11 | acidic |
| pKa3 | 11.12 | acidic |
| pKa4 | 12.11 | acidic |
| pKa5 | 12.74 | acidic |
| pKa6 | 13.88 | acidic |
| pKa7 | 8.62 | Basic |
| pKa8 | 2.4 | Basic |
Orange Book patent data (new drug applications)
None
Orange Book exclusivity data (new drug applications)
None
Bioactivity Summary:
None
External reference:
| ID | Source |
|---|---|
| D03347 | KEGG_DRUG |
| 137397-23-0 | SECONDARY_CAS_RN |
| C0006834 | UMLSCUI |
| CHEBI:354984 | CHEBI |
| CHEMBL1200647 | ChEMBL_ID |
| DB01152 | DRUGBANK_ID |
| 1822 | INN_ID |
| 48N2IYJ202 | UNII |
| 10079874 | PUBCHEM_CID |
| 002890 | NDDF |
| 81816007 | SNOMEDCT_US |
| D002174 | MESH_DESCRIPTOR_UI |
Pharmaceutical products:
None