dihydroergocryptine 🐶 Veterinary Use | Indications/Contra | FAERs-F | FAERs-M | Orange Bk | BioActivity |

Stem definition	Drug id	CAS RN
ergot alkaloid derivatives	4420	25447-66-9

Description:

Molecule

Description

Molfile Inchi Smiles

Synonyms:

Dihydro-.alpha.-ergocryptine
Dihydro-.alpha.-ergocryptine mesylate
dihydroergocryptine mesylate
dihydroergocryptine
dihydroergocriptine
Dihydro-.alpha.-ergocryptine mesilate
dihydroergocryptine mesilate

A 9,10alpha-dihydro derivative of ERGOTAMINE that contains an isopropyl sidechain at the 2' position and an alpha-isobutyl sidechain at 5'alpha position of the molecule.

Molecular weight: 577.73
Formula: C32H43N5O5
CLOGP: 5.60
LIPINSKI: 2
HAC: 10
HDO: 3
TPSA: 118.21
ALOGS: -3.34
ROTB: 5

Drug dosage:

None

ADMET properties:

None

Approvals:

Date	Agency	Company	Orphan
None	FDA

FDA Adverse Event Reporting System (Female)

None

FDA Adverse Event Reporting System (Male)

None

FDA Adverse Event Reporting System (Geriatric)

None

FDA Adverse Event Reporting System (Pediatric)

None

Pharmacologic Action:

Source	Code	Description
ATC	N04BC03	NERVOUS SYSTEM ANTI-PARKINSON DRUGS DOPAMINERGIC AGENTS Dopamine agonists
MeSH PA	D002317	Cardiovascular Agents
MeSH PA	D015259	Dopamine Agents
MeSH PA	D018491	Dopamine Agonists
MeSH PA	D018377	Neurotransmitter Agents
MeSH PA	D014665	Vasodilator Agents

Drug Use | Suggest Off label Use Form| |View source of the data|

None

🐶 Veterinary Drug Use

None

🐶 Veterinary products

None

Acid dissociation constants calculated using MoKa v3.0.0

Dissociation level	Dissociation constant	Type (acidic/basic)
pKa1	12.57	acidic
pKa2	13.18	acidic
pKa3	13.67	acidic
pKa4	7.56	Basic

Orange Book patent data (new drug applications)

None

Orange Book exclusivity data (new drug applications)

None

Bioactivity Summary:

Target	Class	Pharos	UniProt	Action	Type	Activity value (-log[M])	Mechanism action	Bioact source	MoA source
5-hydroxytryptamine receptor 2B	GPCR	P41595	5HT2B_HUMAN	AGONIST	Ki	7.48		IUPHAR
5-hydroxytryptamine receptor 7	GPCR		5HT7R_RAT	ANTAGONIST	Ki	6.50		IUPHAR
5-hydroxytryptamine receptor 7	GPCR		5HT7R_MOUSE	ANTAGONIST	Ki	7		IUPHAR

External reference:

ID	Source
D07835	KEGG_DRUG
14271-05-7	SECONDARY_CAS_RN
4017832	VANDF
4020124	VANDF
C0012290	UMLSCUI
CHEMBL1743263	ChEMBL_ID
CHEMBL3707289	ChEMBL_ID
DB13385	DRUGBANK_ID
282	IUPHAR_LIGAND_ID
67V3FSL2GL	UNII
114948	PUBCHEM_CID
1426902	RXNORM
005801	NDDF
005802	NDDF
24650007	SNOMEDCT_US
412173004	SNOMEDCT_US
426582003	SNOMEDCT_US
708572008	SNOMEDCT_US
D025443	MESH_DESCRIPTOR_UI

Pharmaceutical products:

Product	Category	Ingredients	NDC	Form	Quantity	Route	Marketing	Label
Ergoloid Mesylates	HUMAN PRESCRIPTION DRUG LABEL	4	53489-281	TABLET	0.22 mg	ORAL	ANDA	11 sections
Ergoloid Mesylates	HUMAN PRESCRIPTION DRUG LABEL	4	68151-2780	TABLET	0.22 mg	ORAL	ANDA	10 sections