cobamamide 🐶 Veterinary Use | Indications/Contra | FAERs-F | FAERs-M | Orange Bk | BioActivity |

Stem definitionDrug idCAS RN
4404 13870-90-1

Description:

MoleculeDescription

Synonyms:

  • cobamamide
  • adenosylcobalamin
  • cobalamin coenzyme
  • Vitamin B12 coenzyme
  • Molecular weight: 1579.61
  • Formula: C72H100CoN18O17P
  • CLOGP:
  • LIPINSKI: None
  • HAC: None
  • HDO: None
  • TPSA: 608.02
  • ALOGS:
  • ROTB: None

Drug dosage:

None

ADMET properties:

None

Approvals:

DateAgencyCompanyOrphan
None FDA

FDA Adverse Event Reporting System (Female)

MedDRA adverse event termLikelihood ratioLikelihood ratio thresholdPatients taking drug having adverse eventPatients taking drug not having adverse eventPatients not taking drug having adverse eventPatients not taking drug not having adverse event
Dementia 48.33 41.03 14 515 15983 50588612

FDA Adverse Event Reporting System (Male)

None

FDA Adverse Event Reporting System (Geriatric)

MedDRA adverse event termLikelihood ratioLikelihood ratio thresholdPatients taking drug having adverse eventPatients taking drug not having adverse eventPatients not taking drug having adverse eventPatients not taking drug not having adverse event
Dementia 44.88 38.57 14 651 20752 64477315

FDA Adverse Event Reporting System (Pediatric)

None

Pharmacologic Action:

SourceCodeDescription
ATC B03BA04 BLOOD AND BLOOD FORMING ORGANS
ANTIANEMIC PREPARATIONS
VITAMIN B12 AND FOLIC ACID
Vitamin B12 (cyanocobalamin and analogues)
CHEBI has role CHEBI:23354 coenzymes
CHEBI has role CHEBI:23357 cofactor
CHEBI has role CHEBI:26348 prosthetic groups
CHEBI has role CHEBI:76971 Escherichia coli metabolites
CHEBI has role CHEBI:77746 Homo sapiens metabolite

Drug Use (View source of the data)

DiseaseRelationSNOMED_IDDOID
Prevention of Vitamin B12 Deficiency indication
Hypokalemia contraindication 43339004
Gastrectomy contraindication 53442002
Leber's optic atrophy contraindication 58610003 DOID:705
Atrophic gastritis contraindication 84568007 DOID:8929




🐶 Veterinary Drug Use

None

🐶 Veterinary products

None

Acid dissociation constants calculated using MoKa v3.0.0

None

Orange Book patent data (new drug applications)

None

Orange Book exclusivity data (new drug applications)

None

Bioactivity Summary:

None

External reference:

IDSource
D00042 KEGG_DRUG
C0056039 UMLSCUI
CHEBI:18408 CHEBI
B1Z PDB_CHEM_ID
CHEMBL3833359 ChEMBL_ID
DB11191 DRUGBANK_ID
C000913 MESH_SUPPLEMENTAL_RECORD_UI
1915 INN_ID
F0R1QK73KB UNII
70678541 PUBCHEM_CID
21373 RXNORM
NOCODE MMSL
004345 NDDF
259509008 SNOMEDCT_US

Pharmaceutical products:

ProductCategoryIngredientsNDCFormQuantityRouteMarketingLabel
EnBrace HR HUMAN PRESCRIPTION DRUG LABEL 16 64661-650 CAPSULE, DELAYED RELEASE PELLETS 50 ug ORAL UNAPPROVED DRUG OTHER 11 sections
EnLyte HUMAN PRESCRIPTION DRUG LABEL 18 64661-711 CAPSULE, DELAYED RELEASE PELLETS 50 ug ORAL unapproved drug other 12 sections
Biopar delta-FORTE HUMAN PRESCRIPTION DRUG LABEL 6 64661-793 CAPSULE 50 ug ORAL unapproved drug other 11 sections