ceftobiprole medocaril 🐶 Veterinary Use | Indications/Contra | FAERs-F | FAERs-M | Orange Bk | BioActivity |
| Stem definition | Drug id | CAS RN |
|---|---|---|
| antibiotics, cefalosporanic acid derivatives | 4402 | 376653-43-9 |
Description:
| Molecule | Description |
|---|---|
|
Synonyms:
|
a ceftobiprole prodrug
|
Drug dosage:
| Dose | Unit | Route |
|---|---|---|
| 1.50 | g | P |
ADMET properties:
None
Approvals:
None
FDA Adverse Event Reporting System (Female)
None
FDA Adverse Event Reporting System (Male)
None
FDA Adverse Event Reporting System (Geriatric)
None
FDA Adverse Event Reporting System (Pediatric)
None
Pharmacologic Action:
| Source | Code | Description |
|---|---|---|
| ATC | J01DI01 | ANTIINFECTIVES FOR SYSTEMIC USE ANTIBACTERIALS FOR SYSTEMIC USE OTHER BETA-LACTAM ANTIBACTERIALS Other cephalosporins and penems |
| MeSH PA | D000900 | Anti-Bacterial Agents |
| MeSH PA | D000890 | Anti-Infective Agents |
| CHEBI has role | CHEBI:50266 | Prodrugs |
| CHEBI has role | CHEBI:33281 | antibiotics |
Drug Use | Suggest Off label Use Form| |View source of the data|
| Disease | Relation | SNOMED_ID | DOID |
|---|---|---|---|
| Infection of skin AND/OR subcutaneous tissue | indication | 19824006 |
🐶 Veterinary Drug Use
None
🐶 Veterinary products
None
Acid dissociation constants calculated using MoKa v3.0.0
| Dissociation level | Dissociation constant | Type (acidic/basic) |
|---|---|---|
| pKa1 | 2.38 | acidic |
| pKa2 | 9.57 | acidic |
| pKa3 | 13.11 | acidic |
| pKa4 | 0.87 | Basic |
Orange Book patent data (new drug applications)
None
Orange Book exclusivity data (new drug applications)
None
Bioactivity Summary:
| Target | Class | Pharos | UniProt | Action | Type | Activity value (-log[M]) | Mechanism action | Bioact source | MoA source |
|---|---|---|---|---|---|---|---|---|---|
| MecA | Enzyme | IC50 | 5.49 | CHEMBL |
External reference:
| ID | Source |
|---|---|
| D08885 | KEGG_DRUG |
| C1622308 | UMLSCUI |
| CHEBI:135968 | CHEBI |
| CHEBI:140407 | CHEBI |
| CHEMBL4297101 | ChEMBL_ID |
| CHEMBL1652606 | ChEMBL_ID |
| DB14733 | DRUGBANK_ID |
| C505439 | MESH_SUPPLEMENTAL_RECORD_UI |
| C443755 | MESH_SUPPLEMENTAL_RECORD_UI |
| N99027V28J | UNII |
| 135413543 | PUBCHEM_CID |
| DB04918 | DRUGBANK_ID |
| 012881 | NDDF |
| 012882 | NDDF |
| 734512008 | SNOMEDCT_US |
| 734513003 | SNOMEDCT_US |
| C1100584 | UMLSCUI |
| RB6 | PDB_CHEM_ID |
| CHEMBL520642 | ChEMBL_ID |
| 8531 | INN_ID |
| 252188-71-9 | SECONDARY_CAS_RN |
| 209467-52-7 | SECONDARY_CAS_RN |
| 135413542 | PUBCHEM_CID |
| 10787 | IUPHAR_LIGAND_ID |
| 5T97333YZK | UNII |
Pharmaceutical products:
None