ceftobiprole medocaril Indications/Contra | FAERs-F | FAERs-M | Orange Bk | BioActivity |

Stem definitionDrug idCAS RN
antibiotics, cefalosporanic acid derivatives 4402 376653-43-9

Description:

MoleculeDescription

Molfile Inchi Smiles

Synonyms:

  • ceftobiprole medocaril
  • BAL5788
  • Ro 65-5788
  • ceftobiprole medocaril sodium
  • BAL9141
  • BAL-9141
  • BAL 9141
  • BAL 9141-000
a ceftobiprole prodrug
  • Molecular weight: 690.66
  • Formula: C26H26N8O11S2
  • CLOGP: -2.18
  • LIPINSKI: 2
  • HAC: 19
  • HDO: 4
  • TPSA: 256.48
  • ALOGS: -3.72
  • ROTB: 9

Drug dosage:

DoseUnitRoute
1.50 g P

ADMET properties:

None

Approvals:

None

FDA Adverse Event Reporting System (Female)

None

FDA Adverse Event Reporting System (Male)

None

Pharmacologic Action:

SourceCodeDescription
ATC J01DI01 ANTIINFECTIVES FOR SYSTEMIC USE
ANTIBACTERIALS FOR SYSTEMIC USE
OTHER BETA-LACTAM ANTIBACTERIALS
Other cephalosporins and penems
MeSH PA D000900 Anti-Bacterial Agents
MeSH PA D000890 Anti-Infective Agents
CHEBI has role CHEBI:50266 Prodrugs
CHEBI has role CHEBI:33281 antibiotics

Drug Use (View source of the data)

DiseaseRelationSNOMED_IDDOID
Infection of skin AND/OR subcutaneous tissue indication 19824006

Acid dissociation constants calculated using MoKa v3.0.0

Dissociation levelDissociation constantType (acidic/basic)
pKa1 2.38 acidic
pKa2 9.57 acidic
pKa3 13.11 acidic
pKa4 0.87 Basic

Orange Book patent data (new drug applications)

None

Orange Book exclusivity data (new drug applications)

None

Bioactivity Summary:

TargetClassPharosUniProtActionTypeActivity value
(-log[M])
Mechanism
action
Bioact sourceMoA source
MecA Enzyme IC50 5.49 CHEMBL

External reference:

IDSource
D08885 KEGG_DRUG
252188-71-9 SECONDARY_CAS_RN
209467-52-7 SECONDARY_CAS_RN
C1622308 UMLSCUI
CHEBI:135968 CHEBI
CHEBI:140407 CHEBI
RB6 PDB_CHEM_ID
CHEMBL4297101 ChEMBL_ID
CHEMBL1652606 ChEMBL_ID
DB14733 DRUGBANK_ID
C505439 MESH_SUPPLEMENTAL_RECORD_UI
C443755 MESH_SUPPLEMENTAL_RECORD_UI
10787 IUPHAR_LIGAND_ID
8531 INN_ID
N99027V28J UNII
135413544 PUBCHEM_CID
135413542 PUBCHEM_CID
DB04918 DRUGBANK_ID
5T97333YZK UNII
012881 NDDF
012882 NDDF
734512008 SNOMEDCT_US
734513003 SNOMEDCT_US
C1100584 UMLSCUI
CHEMBL520642 ChEMBL_ID

Pharmaceutical products:

None