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faropenem 🐶 Veterinary Use | Indications/Contra | FAERs-F | FAERs-M | Orange Bk | PK/Tox | Related Drugs | BioActivity |
| Stem definition | Drug id | CAS RN |
|---|---|---|
| analogues of penicillanic acid antibiotics modified in the five-membered ring | 1131 | 106560-14-9 |
Description:
| Molecule | Description |
|---|---|
|
Synonyms:
|
|
Drug dosage:
| Dose | Unit | Route |
|---|---|---|
| 0.75 | g | O |
ADMET properties:
| Property | Value | Reference |
|---|---|---|
| Vd (Volume of distribution) | 0.18 L/kg | Lombardo F, Berellini G, Obach RS |
| CL (Clearance) | 2.23 mL/min/kg | Lombardo F, Berellini G, Obach RS |
| t_half (Half-life) | 1.40 hours | Lombardo F, Berellini G, Obach RS |
| BA (Bioavailability) | 25 % |
Predicted pharmacokinetic/toxicological properties (PK-AZ):
| Property | Description | Value | Unit | Confidence | Similarity |
|---|---|---|---|---|---|
| kinase-safety-class | ACVR2B,CAMK2D,CDK5,EIF2AK3,ERBB2,GRK2,ITK,MAP2K6,MAPK7,NTRK2,PDK1,PDK2,PRKDC,TEK | 14 | |||
| kinase-selectivity-class | AXL,EIF2AK3,GRK2,MAP2K6,MAP3K14,PRKDC,TEK,TGFBR1 | 8 | |||
| pfas-class | PFAS structural alert (1 = True, 0 = False) | 0 |
Approvals:
None
FDA Adverse Event Reporting System (Female)
None
FDA Adverse Event Reporting System (Male)
None
FDA Adverse Event Reporting System (Geriatric)
None
FDA Adverse Event Reporting System (Pediatric)
None
Pharmacologic Action:
| Source | Code | Description |
|---|---|---|
| ATC | J01DI03 | ANTIINFECTIVES FOR SYSTEMIC USE ANTIBACTERIALS FOR SYSTEMIC USE OTHER BETA-LACTAM ANTIBACTERIALS Other cephalosporins and penems |
Related Drugs by ATC class:
J01DI Other cephalosporins and penems 5 drugs
Drug Use | Suggest Off label Use Form| |View source of the data|
| Disease | Relation | SNOMED_ID | DOID |
|---|---|---|---|
| Bacterial infection of skin | indication | 128936008 | |
| Respiratory tract infection | indication | 275498002 |
🐶 Veterinary Drug Use
None
🐶 Veterinary products
None
Acid dissociation constants calculated using MoKa v3.0.0
| Dissociation level | Dissociation constant | Type (acidic/basic) |
|---|---|---|
| pKa1 | 3.21 | acidic |
Orange Book patent data (new drug applications)
None
Orange Book exclusivity data (new drug applications)
None
Bioactivity Summary:
None
External reference:
| ID | Source |
|---|---|
| 122547-49-3 | SECONDARY_CAS_RN |
| CHEBI:51257 | CHEBI |
| FPM | PDB_CHEM_ID |
| D01839 | KEGG_DRUG |
| CHEMBL556262 | ChEMBL_ID |
| CHEMBL431753 | ChEMBL_ID |
| C107057 | MESH_SUPPLEMENTAL_RECORD_UI |
| 10808 | IUPHAR_LIGAND_ID |
| DB12190 | DRUGBANK_ID |
| F52Y83BGH3 | UNII |
| 020030 | NDDF |
| 020031 | NDDF |
| 1162766006 | SNOMEDCT_US |
| 1162884001 | SNOMEDCT_US |
| 1162886004 | SNOMEDCT_US |
| C0541153 | UMLSCUI |
| 7086 | INN_ID |
| 65894 | PUBCHEM_CID |
Pharmaceutical products:
None