casopitant 🐶 Veterinary Use | Indications/Contra | FAERs-F | FAERs-M | Orange Bk | BioActivity |
| Stem definition | Drug id | CAS RN |
|---|---|---|
| neurokinin NK1 (substance P) receptor antagonist | 4401 | 414910-27-3 |
Description:
| Molecule | Description |
|---|---|
|
Synonyms:
|
|
Drug dosage:
None
ADMET properties:
| Property | Value | Reference |
|---|---|---|
| Vd (Volume of distribution) | 2.77 L/kg | Lombardo F, Berellini G, Obach RS |
| CL (Clearance) | 3.07 mL/min/kg | Lombardo F, Berellini G, Obach RS |
| fu (Fraction unbound in plasma) | 1 % | Lombardo F, Berellini G, Obach RS |
| t_half (Half-life) | 15.60 hours | Lombardo F, Berellini G, Obach RS |
Approvals:
None
FDA Adverse Event Reporting System (Female)
None
FDA Adverse Event Reporting System (Male)
None
FDA Adverse Event Reporting System (Geriatric)
None
FDA Adverse Event Reporting System (Pediatric)
None
Pharmacologic Action:
| Source | Code | Description |
|---|---|---|
| ATC | A04AD13 | ALIMENTARY TRACT AND METABOLISM ANTIEMETICS AND ANTINAUSEANTS ANTIEMETICS AND ANTINAUSEANTS Other antiemetics |
| MeSH PA | D000932 | Antiemetics |
| MeSH PA | D002491 | Central Nervous System Agents |
| MeSH PA | D005765 | Gastrointestinal Agents |
| MeSH PA | D064729 | Neurokinin-1 Receptor Antagonists |
| MeSH PA | D018377 | Neurotransmitter Agents |
| MeSH PA | D018373 | Peripheral Nervous System Agents |
Drug Use | Suggest Off label Use Form| |View source of the data|
None
🐶 Veterinary Drug Use
None
🐶 Veterinary products
None
Acid dissociation constants calculated using MoKa v3.0.0
| Dissociation level | Dissociation constant | Type (acidic/basic) |
|---|---|---|
| pKa1 | 6.7 | Basic |
Orange Book patent data (new drug applications)
None
Orange Book exclusivity data (new drug applications)
None
Bioactivity Summary:
| Target | Class | Pharos | UniProt | Action | Type | Activity value (-log[M]) | Mechanism action | Bioact source | MoA source |
|---|---|---|---|---|---|---|---|---|---|
| Substance-P receptor | GPCR | ANTAGONIST | Ki | 9.90 | CHEMBL | SCIENTIFIC LITERATURE | |||
| Sigma non-opioid intracellular receptor 1 | Membrane receptor | Ki | 5.53 | CHEMBL |
External reference:
| ID | Source |
|---|---|
| D06574 | KEGG_DRUG |
| C2347566 | UMLSCUI |
| CHEBI:135967 | CHEBI |
| CHEMBL1672054 | ChEMBL_ID |
| DB06634 | DRUGBANK_ID |
| C531951 | MESH_SUPPLEMENTAL_RECORD_UI |
| 5758 | IUPHAR_LIGAND_ID |
| 8701 | INN_ID |
| 414910-30-8 | SECONDARY_CAS_RN |
| 3B03KPM27L | UNII |
| 9917021 | PUBCHEM_CID |
| CHEMBL2107320 | ChEMBL_ID |
Pharmaceutical products:
None