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2022 Update-Veterinary Drugs & Uses
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L1000
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DrugCentral 2023 🐕
2022 Update-Veterinary Drugs & Uses
Search
Structure 🔎
Similarity 🔎
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L1000
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All
FDA-approved
EMA-approved
PMDA-approved
Target Card Uniprot Example:
P23975
metopimazine 🐶
Veterinary Use |
Indications/Contra
| FAERs-F
| FAERs-M
| Orange Bk
| BioActivity |
Stem definition
Drug id
CAS RN
1784
14008-44-7
Description:
Molecule
Description
Molfile
Inchi
Smiles
Synonyms:
metopimazine hydrochloride
metopimazine HCl
metopimazine
vogalene
Molecular weight: 445.60
Formula: C22H27N3O3S2
CLOGP: 1.30
LIPINSKI: 0
HAC: 6
HDO: 1
TPSA: 83.71
ALOGS: -4.37
ROTB: 6
Drug dosage:
Dose
Unit
Route
15
mg
O
15
mg
P
ADMET properties:
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Property
Value
Reference
t_half (Half-life)
4 hours
Lombardo F, Berellini G, Obach RS
BA (Bioavailability)
20 %
Kim MT, Sedykh A, Chakravarti SK, Saiakhov RD, Zhu H
CL (Clearance)
12.14 mL/min/kg
Lombardo F, Berellini G, Obach RS
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Approvals:
None
FDA Adverse Event Reporting System (Female)
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MedDRA adverse event term
Likelihood ratio
Likelihood ratio threshold
Patients taking drug having adverse event
Patients taking drug not having adverse event
Patients not taking drug having adverse event
Patients not taking drug not having adverse event
Acute kidney injury
78.08
36.80
54
1211
263361
63224396
Cholestasis
58.51
36.80
22
1243
29412
63458345
Febrile bone marrow aplasia
50.11
36.80
14
1251
7311
63480446
Drug reaction with eosinophilia and systemic symptoms
48.62
36.80
20
1245
33816
63453941
Hyperkalaemia
45.56
36.80
22
1243
54181
63433576
Poisoning deliberate
40.11
36.80
13
1252
11205
63476552
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FDA Adverse Event Reporting System (Male)
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MedDRA adverse event term
Likelihood ratio
Likelihood ratio threshold
Patients taking drug having adverse event
Patients taking drug not having adverse event
Patients not taking drug having adverse event
Patients not taking drug not having adverse event
Analgesic drug level increased
52.82
49.92
10
760
846
34955315
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1
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FDA Adverse Event Reporting System (Geriatric)
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MedDRA adverse event term
Likelihood ratio
Likelihood ratio threshold
Patients taking drug having adverse event
Patients taking drug not having adverse event
Patients not taking drug having adverse event
Patients not taking drug not having adverse event
Acute kidney injury
102.83
34.48
95
2045
519309
79222939
Coma
57.61
34.48
35
2105
100614
79641634
Cholestasis
57.48
34.48
28
2112
52081
79690167
Poisoning deliberate
54.16
34.48
20
2120
18808
79723440
Drug reaction with eosinophilia and systemic symptoms
51.94
34.48
28
2112
64216
79678032
Febrile bone marrow aplasia
41.79
34.48
15
2125
13005
79729243
Hepatitis
41.46
34.48
23
2117
55704
79686544
Hyperkalaemia
39.35
34.48
29
2111
114369
79627879
Analgesic drug level increased
37.75
34.48
10
2130
3168
79739080
Thrombocytopenia
36.42
34.48
40
2100
265219
79477029
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FDA Adverse Event Reporting System (Pediatric)
None
Pharmacologic Action:
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Source
Code
Description
ATC
A04AD05
ALIMENTARY TRACT AND METABOLISM
ANTIEMETICS AND ANTINAUSEANTS
ANTIEMETICS AND ANTINAUSEANTS
Other antiemetics
MeSH PA
D000932
Antiemetics
MeSH PA
D002491
Central Nervous System Agents
MeSH PA
D005765
Gastrointestinal Agents
MeSH PA
D018373
Peripheral Nervous System Agents
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Drug Use
| Suggest Off label Use Form|
|View source of the data|
None
🐶 Veterinary Drug Use
None
🐶 Veterinary products
None
Acid dissociation constants calculated using MoKa v3.0.0
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Dissociation level
Dissociation constant
Type (acidic/basic)
pKa1
13.41
acidic
pKa2
8.95
Basic
pKa3
3.45
Basic
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Orange Book patent data (new drug applications)
None
Orange Book exclusivity data (new drug applications)
None
Bioactivity Summary:
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Target
Class
Pharos
UniProt
Action
Type
Activity value
(-log[M])
Mechanism
action
Bioact source
MoA source
D(2) dopamine receptor
GPCR
P14416
DRD2_HUMAN
Ki
10.15
CHEMBL
D(3) dopamine receptor
GPCR
P35462
DRD3_HUMAN
Ki
9.21
CHEMBL
Histamine H1 receptor
GPCR
P35367
HRH1_HUMAN
Ki
8.08
CHEMBL
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External reference:
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ID
Source
005826
NDDF
11140
IUPHAR_LIGAND_ID
2178
INN_ID
238S75V9AV
UNII
26388
PUBCHEM_CID
29954
RXNORM
C005260
MESH_SUPPLEMENTAL_RECORD_UI
C0066469
UMLSCUI
CHEBI:135726
CHEBI
CHEMBL398615
ChEMBL_ID
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Pharmaceutical products:
None
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metopimazine