tegafur 🐶 Veterinary Use | Indications/Contra | FAERs-F | FAERs-M | Orange Bk | BioActivity |
| Stem definition | Drug id | CAS RN |
|---|---|---|
| uridine derivatives used as antiviral agents and as antineoplastics | 4398 | 17902-23-7 |
Description:
| Molecule | Description |
|---|---|
|
Synonyms:
|
Congener of FLUOROURACIL with comparable antineoplastic action. It has been suggested especially for the treatment of breast neoplasms.
|
Drug dosage:
None
ADMET properties:
| Property | Value | Reference |
|---|---|---|
| Vd (Volume of distribution) | 0.62 L/kg | Lombardo F, Berellini G, Obach RS |
| CL (Clearance) | 0.95 mL/min/kg | Lombardo F, Berellini G, Obach RS |
| t_half (Half-life) | 8.69 hours | Lombardo F, Berellini G, Obach RS |
Approvals:
| Date | Agency | Company | Orphan |
|---|---|---|---|
| March 14, 2011 | EMA | Nordic Group BV | |
| March 1, 1999 | PMDA | Taiho Pharmaceutical Co, Ltd |
FDA Adverse Event Reporting System (Female)
None
FDA Adverse Event Reporting System (Male)
None
FDA Adverse Event Reporting System (Geriatric)
| MedDRA adverse event term | Likelihood ratio | Likelihood ratio threshold | Patients taking drug having adverse event | Patients taking drug not having adverse event | Patients not taking drug having adverse event | Patients not taking drug not having adverse event |
|---|---|---|---|---|---|---|
| Bone marrow failure | 72.12 | 47.42 | 20 | 305 | 51087 | 79692976 |
| Myelosuppression | 53.23 | 47.42 | 15 | 310 | 40281 | 79703782 |
FDA Adverse Event Reporting System (Pediatric)
None
Pharmacologic Action:
| Source | Code | Description |
|---|---|---|
| ATC | L01BC03 | ANTINEOPLASTIC AND IMMUNOMODULATING AGENTS ANTINEOPLASTIC AGENTS ANTIMETABOLITES Pyrimidine analogues |
| ATC | L01BC53 | ANTINEOPLASTIC AND IMMUNOMODULATING AGENTS ANTINEOPLASTIC AGENTS ANTIMETABOLITES Pyrimidine analogues |
| MeSH PA | D000963 | Antimetabolites |
| MeSH PA | D000964 | Antimetabolites, Antineoplastic |
| MeSH PA | D000970 | Antineoplastic Agents |
| MeSH PA | D009676 | Noxae |
Drug Use | Suggest Off label Use Form| |View source of the data|
| Disease | Relation | SNOMED_ID | DOID |
|---|---|---|---|
| Malignant tumor of stomach | indication | 363349007 | DOID:10534 |
| Hormone receptor pozitive breast cancer | indication | 417181009 | |
| HER2negative breast cancer | indication | 767444009 |
🐶 Veterinary Drug Use
None
🐶 Veterinary products
None
Acid dissociation constants calculated using MoKa v3.0.0
| Dissociation level | Dissociation constant | Type (acidic/basic) |
|---|---|---|
| pKa1 | 7.81 | acidic |
Orange Book patent data (new drug applications)
None
Orange Book exclusivity data (new drug applications)
None
Bioactivity Summary:
None
External reference:
| ID | Source |
|---|---|
| D01244 | KEGG_DRUG |
| N0000167181 | NUI |
| C0016778 | UMLSCUI |
| CHEBI:32188 | CHEBI |
| S7W | PDB_CHEM_ID |
| CHEMBL20883 | ChEMBL_ID |
| DB09256 | DRUGBANK_ID |
| 10513 | IUPHAR_LIGAND_ID |
| 4415 | INN_ID |
| 1548R74NSZ | UNII |
| 5386 | PUBCHEM_CID |
| 4582 | RXNORM |
| 007248 | NDDF |
| 395897006 | SNOMEDCT_US |
| 421459003 | SNOMEDCT_US |
| D005641 | MESH_DESCRIPTOR_UI |
Pharmaceutical products:
None