All FDA-approved EMA-approved PMDA-approved
Target Card Uniprot Example: P23975

cisplatin 🐶 Veterinary Use | Indications/Contra | FAERs-F | FAERs-M | Orange Bk | BioActivity |

Stem definition	Drug id	CAS RN
antineoplastic agents, platinum derivatives	4392	15663-27-1

Description:

Molecule

Description

Synonyms: cisplatin platinum diamminodichloride cis-Platinum

An inorganic and water-soluble platinum complex. After undergoing hydrolysis, it reacts with DNA to produce both intra and interstrand crosslinks. These crosslinks appear to impair replication and transcription of DNA. The cytotoxicity of cisplatin correlates with cellular arrest in the G2 phase of the cell cycle. Molecular weight: 300.05 Formula: Cl2H6N2Pt CLOGP: LIPINSKI: None HAC: None HDO: None TPSA: ALOGS: ROTB: None

Drug dosage:

None

ADMET properties:

Property	Value	Reference
BDDCS (Biopharmaceutical Drug Disposition Classification System)	1	Benet LZ, Broccatelli F, Oprea TI
S (Water solubility)	2.53 mg/mL	Benet LZ, Broccatelli F, Oprea TI
EoM (Fraction excreted unchanged in urine)	2.30 %	Benet LZ, Broccatelli F, Oprea TI
MRTD (Maximum Recommended Therapeutic Daily Dose)	4.75 µM/kg/day	Contrera JF, Matthews EJ, Kruhlak NL, Benz RD

Approvals:

Date	Agency	Company	Orphan
Dec. 19, 1978	FDA	HQ SPCLT PHARMA

FDA Adverse Event Reporting System (Female)

MedDRA adverse event term	Likelihood ratio	Likelihood ratio threshold	Patients taking drug having adverse event	Patients taking drug not having adverse event	Patients not taking drug having adverse event	Patients not taking drug not having adverse event
Febrile neutropenia	1109.96	15.79	880	54501	104665	56132021
Neutropenia	1031.91	15.79	1005	54376	157162	56079524
Thrombocytopenia	753.00	15.79	792	54589	135432	56101254
Disease progression	634.11	15.79	641	54740	104532	56132154
Malignant neoplasm progression	593.39	15.79	527	54854	73060	56163626
Bone marrow failure	497.48	15.79	323	55058	27963	56208723
Mucosal inflammation	496.84	15.79	379	55002	42431	56194255
Haematotoxicity	491.43	15.79	214	55167	8169	56228517
Anaemia	422.35	15.79	858	54523	266653	55970033
Vomiting	418.50	15.79	1253	54128	496975	55739711
Ototoxicity	411.54	15.79	114	55267	1052	56235634
Pancytopenia	360.18	15.79	440	54941	88275	56148411
Myelosuppression	340.85	15.79	213	55168	17242	56219444
Nausea	279.80	15.79	1481	53900	762697	55473989
Leukopenia	272.00	15.79	342	55039	70598	56166088
Arthralgia	269.54	15.79	80	55301	501589	55735097
Acute myeloid leukaemia	267.31	15.79	181	55200	16791	56219895
Dehydration	263.88	15.79	521	54860	158304	56078382
Posterior reversible encephalopathy syndrome	246.10	15.79	168	55213	15792	56220894
Second primary malignancy	240.62	15.79	126	55255	7276	56229410
Hypomagnesaemia	229.36	15.79	193	55188	24822	56211864
Off label use	223.08	15.79	1107	54274	555073	55681613
Joint swelling	218.03	15.79	18	55363	289782	55946904
Neutrophil count decreased	195.38	15.79	243	55138	49579	56187107
Hypokalaemia	188.08	15.79	335	55046	94102	56142584
Renal salt-wasting syndrome	181.80	15.79	46	55335	287	56236399
Pain	178.04	15.79	236	55145	662948	55573738
Deafness	171.62	15.79	137	55244	16357	56220329
Ovarian germ cell teratoma	166.44	15.79	35	55346	78	56236608
Myelodysplastic syndrome	165.88	15.79	134	55247	16272	56220414
Diffuse large B-cell lymphoma recurrent	165.30	15.79	63	55318	1694	56234992
Abdominal discomfort	162.37	15.79	37	55344	277237	55959449
Teratoma	160.85	15.79	37	55344	143	56236543
Arthropathy	160.58	15.79	9	55372	200266	56036420
Neutropenic sepsis	153.47	15.79	124	55257	15061	56221625
Aortic thrombosis	150.52	15.79	51	55330	966	56235720
Metastases to lung	149.74	15.79	110	55271	11608	56225078
Neoplasm progression	146.59	15.79	169	55212	31847	56204839
Peripheral swelling	146.35	15.79	27	55354	234699	56001987
Platelet count decreased	146.09	15.79	323	55058	106060	56130626
Product dose omission issue	145.22	15.79	16	55365	204737	56031949
Nephropathy toxic	144.02	15.79	95	55286	8432	56228254
Drug resistance	143.62	15.79	136	55245	20406	56216280
Metastases to central nervous system	141.87	15.79	108	55273	12028	56224658
Contraindicated product administered	141.60	15.79	11	55370	186275	56050411
Gastrointestinal toxicity	140.38	15.79	83	55298	6073	56230613
Fall	138.31	15.79	91	55290	357419	55879267
Therapeutic product effect decreased	134.64	15.79	8	55373	169444	56067242
Musculoskeletal stiffness	131.56	15.79	5	55376	156002	56080684
Sepsis	130.16	15.79	366	55015	139474	56097212
Diffuse large B-cell lymphoma refractory	126.30	15.79	46	55335	1086	56235600
Swelling	123.49	15.79	41	55340	239730	55996956
Acute kidney injury	119.44	15.79	511	54870	240252	55996434
Pulmonary embolism	118.52	15.79	299	55082	106825	56129861
Hyponatraemia	116.05	15.79	288	55093	101851	56134835
Pyrexia	112.33	15.79	750	54631	418023	55818663
Weight increased	110.29	15.79	44	55337	229659	56007027
Urogenital fistula	109.80	15.79	28	55353	181	56236505
Drug hypersensitivity	107.79	15.79	69	55312	275136	55961550
Hypocalcaemia	107.49	15.79	137	55244	28623	56208063
Neurotoxicity	107.42	15.79	103	55278	15692	56220994
Cardiomyopathy	104.90	15.79	103	55278	16155	56220531
Nasopharyngitis	103.37	15.79	44	55337	220915	56015771
Cardiotoxicity	100.43	15.79	73	55308	7577	56229109
Oesophagitis	100.04	15.79	94	55287	13963	56222723
Pain in extremity	96.87	15.79	90	55291	297341	55939345
Metastases to liver	95.54	15.79	112	55269	21474	56215212
Wound	95.52	15.79	12	55369	138792	56097894
Rash	94.17	15.79	217	55164	492830	55743856
Pruritus	93.80	15.79	104	55277	316519	55920167
Headache	92.24	15.79	265	55116	558779	55677907
Product use in unapproved indication	91.83	15.79	326	55055	140496	56096190
Tumour lysis syndrome	91.48	15.79	70	55311	7853	56228833
Drug ineffective	90.19	15.79	534	54847	918455	55318231
Metastases to lymph nodes	88.84	15.79	67	55314	7356	56229330
Septic shock	88.33	15.79	189	55192	60646	56176040
Hydronephrosis	88.19	15.79	73	55308	9169	56227517
Therapy partial responder	88.18	15.79	68	55313	7717	56228969
Renal failure	87.33	15.79	273	55108	110227	56126459
Disease recurrence	85.00	15.79	111	55270	23749	56212937
Arthritis	84.85	15.79	3	55378	99849	56136837
Neuropathy peripheral	84.83	15.79	258	55123	102635	56134051
Sinusitis	82.29	15.79	46	55335	197535	56039151
White blood cell count decreased	81.55	15.79	291	55090	125699	56110987
Hypophagia	81.38	15.79	120	55261	28756	56207930
Asthma	79.43	15.79	9	55372	112761	56123925
Insomnia	79.42	15.79	45	55336	191815	56044871
Condition aggravated	79.35	15.79	136	55245	344762	55891924
Contusion	77.40	15.79	16	55365	128414	56108272
Pericarditis	75.95	15.79	9	55372	108914	56127772
Injection site pain	73.95	15.79	13	55368	117105	56119581
Tinnitus	73.61	15.79	117	55264	29925	56206761
Drug intolerance	73.02	15.79	92	55289	264726	55971960
Oesophageal fistula	72.83	15.79	19	55362	136	56236550
Hepatic enzyme increased	72.67	15.79	39	55342	171345	56065341
Blister	71.17	15.79	11	55370	108876	56127810
Renal tubular disorder	71.16	15.79	39	55342	2467	56234219
Teratoma benign	70.57	15.79	16	55365	57	56236629
Ascites	69.34	15.79	129	55252	37415	56199271
Febrile bone marrow aplasia	69.23	15.79	55	55326	6517	56230169
Migraine	69.21	15.79	4	55377	86793	56149893
Electrolyte imbalance	67.53	15.79	86	55295	17947	56218739
Palmar-plantar erythrodysaesthesia syndrome	67.39	15.79	93	55288	20972	56215714
Ovarian cancer recurrent	66.85	15.79	29	55352	1095	56235591
Renal impairment	64.29	15.79	200	55181	80513	56156173
Radiation skin injury	63.36	15.79	26	55355	853	56235833
Muscle spasms	63.18	15.79	28	55353	137343	56099343
Metastases to skin	62.66	15.79	30	55351	1428	56235258
Gastrointestinal perforation	62.32	15.79	39	55342	3160	56233526
Decreased appetite	61.20	15.79	397	54984	218834	56017852
Metastases to bone	60.72	15.79	85	55296	19423	56217263
Leukoencephalopathy	60.62	15.79	42	55339	4040	56232646
Discomfort	60.46	15.79	32	55349	141729	56094957
Renal tubular necrosis	59.65	15.79	63	55318	10765	56225921
Diarrhoea	59.21	15.79	918	54463	637589	55599097
Pleural effusion	58.36	15.79	201	55180	85279	56151407
Infusion related reaction	58.18	15.79	72	55309	208859	56027827
Metastases to breast	56.29	15.79	18	55363	282	56236404
Abdominal pain	56.17	15.79	441	54940	258364	55978322
Deafness bilateral	55.83	15.79	27	55354	1314	56235372
Osteoarthritis	55.08	15.79	7	55374	80289	56156397
Polyneuropathy	54.92	15.79	66	55315	12984	56223702
Loss of personal independence in daily activities	53.67	15.79	8	55373	81361	56155325
Alopecia	52.84	15.79	133	55248	293325	55943361
Blood creatinine increased	52.52	15.79	186	55195	80005	56156681
Large intestine perforation	51.13	15.79	50	55331	7801	56228885
Urticaria	50.40	15.79	41	55340	144635	56092051
Deep vein thrombosis	49.09	15.79	177	55204	76800	56159886
Gait disturbance	49	15.79	53	55328	163268	56073418
Inappropriate antidiuretic hormone secretion	49.00	15.79	64	55317	13692	56222994
Myasthenia gravis crisis	48.56	15.79	18	55363	447	56236239
Haemoglobin decreased	48.43	15.79	260	55121	133877	56102809
Overdose	47.98	15.79	22	55359	105808	56130878
Metastases to peritoneum	47.19	15.79	32	55349	2972	56233714
Fatigue	46.76	15.79	524	54857	788028	55448658
Fibromyalgia	46.75	15.79	3	55378	59600	56177086
Feeling abnormal	46.36	15.79	38	55343	133564	56103122
Depression	46.13	15.79	66	55315	180051	56056635
Peripheral artery thrombosis	45.94	15.79	26	55355	1751	56234935
Injection site erythema	45.93	15.79	10	55371	77438	56159248
Encephalopathy	45.90	15.79	105	55276	35220	56201466
Mobility decreased	45.78	15.79	20	55361	98971	56137715
Suicidal ideation	45.01	15.79	3	55378	57739	56178947
Bronchitis	44.12	15.79	28	55353	112283	56124403
Mesenteric abscess	41.43	15.79	11	55370	85	56236601
Plasma cell leukaemia	40.92	15.79	21	55360	1162	56235524
Drug clearance decreased	40.88	15.79	22	55359	1342	56235344
Malignant transformation	40.56	15.79	15	55366	370	56236316
Chemical peritonitis	40.45	15.79	11	55370	94	56236592
Hospitalisation	40.03	15.79	12	55369	74988	56161698
Ileus	39.55	15.79	58	55323	13824	56222862
Cystitis haemorrhagic	39.45	15.79	32	55349	3905	56232781
Injury	39.21	15.79	6	55375	59845	56176841
Bicytopenia	39.05	15.79	25	55356	2108	56234578
Large intestinal ulcer perforation	38.91	15.79	10	55371	67	56236619
Cytopenia	38.88	15.79	48	55333	9707	56226979
Somnolence	38.83	15.79	63	55318	163350	56073336
Asthenia	38.36	15.79	510	54871	342463	55894223
Anastomotic leak	38.19	15.79	15	55366	438	56236248
Lower respiratory tract infection	38.18	15.79	34	55347	114760	56121926
Recall phenomenon	37.91	15.79	16	55365	564	56236122
Gastric perforation	37.88	15.79	22	55359	1556	56235130
Cervix carcinoma recurrent	37.76	15.79	9	55372	42	56236644
Performance status decreased	37.58	15.79	29	55352	3294	56233392
Adverse drug reaction	37.44	15.79	9	55372	65123	56171563
Wernicke's encephalopathy	37.40	15.79	8	55373	20	56236666
Exposure during pregnancy	36.88	15.79	48	55333	136294	56100392
Cervix neoplasm	36.67	15.79	12	55369	203	56236483
Ureteric rupture	36.63	15.79	7	55374	7	56236679
Cataract	36.30	15.79	4	55377	51243	56185443
Nasal abscess	36.22	15.79	11	55370	144	56236542
Balance disorder	36.12	15.79	15	55366	76505	56160181
Dermatitis	35.71	15.79	58	55323	15099	56221587
Embryonal rhabdomyosarcoma	35.70	15.79	7	55374	9	56236677
Nephritis bacterial	35.62	15.79	8	55373	27	56236659
Maternal exposure during pregnancy	35.59	15.79	84	55297	189469	56047217
Bladder perforation	35.41	15.79	11	55370	156	56236530
Dizziness	35.33	15.79	221	55160	375919	55860767
Blood cholesterol increased	34.62	15.79	14	55367	72565	56164121
Metastases to abdominal wall	34.59	15.79	10	55371	109	56236577
Pericardial effusion	34.45	15.79	80	55301	27095	56209591
Cardiac tamponade	34.21	15.79	31	55350	4395	56232291
Radiation injury	34.18	15.79	14	55367	457	56236229
Intentional product misuse	34.11	15.79	5	55376	51499	56185187
Gastrointestinal fungal infection	34.08	15.79	12	55369	256	56236430
Nasal congestion	33.99	15.79	7	55374	56363	56180323
Cerebral venous thrombosis	33.98	15.79	22	55359	1891	56234795
Melanoderma	33.96	15.79	11	55370	180	56236506
Injection site reaction	33.40	15.79	6	55375	53241	56183445
Neutropenic colitis	33.36	15.79	25	55356	2718	56233968
Lung adenocarcinoma	33.33	15.79	31	55350	4543	56232143
Treatment failure	33.20	15.79	74	55307	170318	56066368
Adverse event	33.14	15.79	7	55374	55369	56181317
Unevaluable event	33.08	15.79	4	55377	47683	56189003
Folliculitis	32.80	15.79	7	55374	54972	56181714
Varicella zoster virus infection	32.43	15.79	24	55357	2560	56234126
Chloroma	32.28	15.79	11	55370	212	56236474
Stress	32.22	15.79	9	55372	58901	56177785
Malnutrition	32.19	15.79	53	55328	13955	56222731
Peripheral ischaemia	32.05	15.79	30	55351	4433	56232253
Cerebellar haemangioma	32.02	15.79	9	55372	88	56236598
Osteosarcoma	31.74	15.79	10	55371	149	56236537
Haemophagocytic lymphohistiocytosis	31.73	15.79	43	55338	9529	56227157
Tumour haemorrhage	31.46	15.79	19	55362	1445	56235241
Metastases to adrenals	31.42	15.79	15	55366	709	56235977
Axillary vein thrombosis	31.30	15.79	12	55369	328	56236358
Herpes simplex encephalitis	31.19	15.79	12	55369	331	56236355
Wheezing	30.44	15.79	18	55363	75008	56161678
Venoocclusive liver disease	30.38	15.79	29	55352	4392	56232294
Metastasis	30.28	15.79	30	55351	4754	56231932
Enteritis	30.27	15.79	37	55344	7406	56229280
Respiratory failure	30.14	15.79	178	55203	94884	56141802
Vesical fistula	30.00	15.79	8	55373	63	56236623
Anxiety	29.96	15.79	94	55287	193078	56043608
Cervix carcinoma	29.93	15.79	24	55357	2881	56233805
Abortion spontaneous	29.56	15.79	4	55377	43749	56192937
Haemolytic uraemic syndrome	29.40	15.79	22	55359	2386	56234300
Product use issue	29.22	15.79	90	55291	185951	56050735
Peripheral sensory neuropathy	28.97	15.79	35	55346	6921	56229765
Neoplasm recurrence	28.95	15.79	22	55359	2442	56234244
Diffuse large B-cell lymphoma	28.73	15.79	35	55346	6981	56229705
Ovarian cancer	28.66	15.79	33	55348	6205	56230481
White blood cell count abnormal	28.59	15.79	32	55349	5835	56230851
Osteoporosis	28.38	15.79	8	55373	52044	56184642
Dysphagia	28.31	15.79	157	55224	81790	56154896
Female genital tract fistula	28.12	15.79	28	55353	4464	56232222
Wrong technique in product usage process	28.11	15.79	11	55370	58157	56178529
Sinus polyp	27.95	15.79	11	55370	323	56236363
Vena cava thrombosis	27.74	15.79	20	55361	2049	56234637
Acoustic stimulation tests abnormal	27.61	15.79	8	55373	88	56236598
Disseminated intravascular coagulation	27.61	15.79	57	55324	17828	56218858
Enterocolitis infectious	27.51	15.79	18	55363	1575	56235111
Impaired healing	27.36	15.79	27	55354	86814	56149872
Inappropriate schedule of product administration	27.36	15.79	25	55356	83362	56153324
Gastrooesophageal reflux disease	27.27	15.79	25	55356	83232	56153454
Memory impairment	27.17	15.79	27	55354	86530	56150156
Hypophosphataemia	26.87	15.79	40	55341	9662	56227024
Alveolar soft part sarcoma	26.75	15.79	8	55373	99	56236587
Adrenocortical carcinoma	26.72	15.79	7	55374	51	56236635
Malaise	26.46	15.79	233	55148	367627	55869059
Cervix cancer metastatic	26.37	15.79	7	55374	54	56236632
Suicide attempt	26.24	15.79	12	55369	57824	56178862
Chronic kidney disease	26.20	15.79	96	55285	41960	56194726
Pneumonia salmonella	26.17	15.79	5	55376	5	56236681
Radiation pneumonitis	26.14	15.79	17	55364	1472	56235214
Clostridium bacteraemia	25.92	15.79	9	55372	184	56236502
Intestinal perforation	25.90	15.79	42	55339	10917	56225769
Acquired gene mutation	25.73	15.79	14	55367	873	56235813
Ill-defined disorder	25.68	15.79	18	55363	68525	56168161
Hypoalbuminaemia	25.57	15.79	41	55340	10558	56226128
Bacteraemia	25.53	15.79	51	55330	15580	56221106
Thymus enlargement	25.53	15.79	8	55373	117	56236569
Hypersensitivity	25.44	15.79	148	55233	256260	55980426
Aortic embolus	25.35	15.79	6	55375	27	56236659
Osteosarcoma metastatic	25.35	15.79	6	55375	27	56236659
Neutrophil count abnormal	25.28	15.79	21	55360	2649	56234037
Fistula of small intestine	24.81	15.79	10	55371	313	56236373
Metastases to abdominal cavity	24.74	15.79	11	55370	441	56236245
Amputation stump pain	24.67	15.79	6	55375	31	56236655
Multiple organ dysfunction syndrome	24.54	15.79	110	55271	52660	56184026
Respiratory symptom	24.48	15.79	21	55360	2769	56233917
Influenza like illness	24.23	15.79	15	55366	60973	56175713
Metastases to meninges	23.91	15.79	19	55362	2251	56234435
Stem cell transplant	23.71	15.79	17	55364	1727	56234959
Jaw operation	23.58	15.79	13	55368	832	56235854
Thrombotic microangiopathy	23.52	15.79	37	55344	9374	56227312
Extremity necrosis	23.44	15.79	16	55365	1502	56235184
Arteriospasm coronary	23.32	15.79	23	55358	3624	56233062
Oesophageal stenosis	23.20	15.79	21	55360	2972	56233714
Pneumonitis	23.09	15.79	76	55305	31488	56205198
Acute respiratory distress syndrome	22.96	15.79	60	55321	21866	56214820
Enterococcal sepsis	22.90	15.79	15	55366	1315	56235371
Embolism	22.79	15.79	32	55349	7332	56229354
Urinary tract infection bacterial	22.71	15.79	25	55356	4475	56232211
Anti-Muellerian hormone level decreased	22.68	15.79	7	55374	97	56236589
Radiation oesophagitis	22.50	15.79	9	55372	276	56236410
Malignant peritoneal neoplasm	22.42	15.79	12	55369	724	56235962
Acute myelomonocytic leukaemia	22.32	15.79	8	55373	180	56236506
Gestational trophoblastic tumour	22.31	15.79	6	55375	49	56236637
Burning sensation	22.25	15.79	10	55371	48686	56188000
Incorrect dose administered	22.19	15.79	12	55369	52535	56184151
Blood magnesium decreased	22.17	15.79	41	55340	11833	56224853
Fluid retention	21.90	15.79	13	55368	54065	56182621
Hypoaesthesia	21.82	15.79	69	55312	141422	56095264
Odynophagia	21.65	15.79	30	55351	6788	56229898
Ovarian vein thrombosis	21.50	15.79	6	55375	57	56236629
Femur fracture	21.49	15.79	6	55375	39289	56197397
Vascular compression	21.47	15.79	7	55374	117	56236569
Oroticaciduria	21.47	15.79	4	55377	3	56236683
Influenza	21.44	15.79	38	55343	95223	56141463
Sleep disorder	21.36	15.79	21	55360	67642	56169044
Median nerve injury	21.22	15.79	5	55376	22	56236664
Tachycardia	21.06	15.79	177	55204	105699	56130987
Failure to thrive	21	15.79	29	55352	6541	56230145
Maternal death affecting foetus	20.93	15.79	4	55377	4	56236682
Therapy responder	20.87	15.79	9	55372	335	56236351
Lymphopenia	20.84	15.79	49	55332	16725	56219961
Blood glucose increased	20.78	15.79	26	55355	75125	56161561
Vision blurred	20.62	15.79	31	55350	82912	56153774
Blood pressure fluctuation	20.57	15.79	7	55374	40353	56196333
Pulmonary vascular disorder	20.50	15.79	9	55372	350	56236336
Cytomegalovirus infection	20.41	15.79	53	55328	19243	56217443
Blood sodium decreased	20.28	15.79	58	55323	22276	56214410
Small cell lung cancer	20.18	15.79	15	55366	1611	56235075
Pregnancy	20.13	15.79	4	55377	33029	56203657
Radiation proctitis	20.04	15.79	4	55377	6	56236680
Superior sagittal sinus thrombosis	19.78	15.79	11	55370	716	56235970
Peritonitis	19.77	15.79	47	55334	16155	56220531
VIth nerve paresis	19.72	15.79	6	55375	79	56236607
Renal-limited thrombotic microangiopathy	19.66	15.79	4	55377	7	56236679
Refeeding syndrome	19.65	15.79	5	55376	32	56236654
Metastases to pelvis	19.65	15.79	9	55372	387	56236299
Hiccups	19.59	15.79	16	55365	1972	56234714
Diabetes mellitus	19.56	15.79	14	55367	52721	56183965
Neck pain	19.55	15.79	19	55362	61536	56175150
Gastrointestinal necrosis	19.53	15.79	18	55363	2608	56234078
Radiation mucositis	19.52	15.79	5	55376	33	56236653
Respiratory distress	19.49	15.79	72	55309	31595	56205091
Drug clearance increased	19.26	15.79	6	55375	86	56236600
Myalgia	19.24	15.79	66	55315	131959	56104727
Granulocytopenia	19.24	15.79	25	55356	5319	56231367
Leukaemic lymphoma	19.19	15.79	6	55375	87	56236599
Lymphangioleiomyomatosis	19.19	15.79	7	55374	166	56236520
Purulent pericarditis	19.02	15.79	5	55376	37	56236649
Product quality issue	19.01	15.79	4	55377	31732	56204954
Medulloblastoma recurrent	19.00	15.79	6	55375	90	56236596
Salivary gland cancer	18.80	15.79	7	55374	176	56236510
Low cardiac output syndrome	18.77	15.79	8	55373	289	56236397
Aortitis	18.72	15.79	12	55369	1014	56235672
Marchiafava-Bignami disease	18.70	15.79	4	55377	10	56236676
Hepatic lesion	18.69	15.79	22	55359	4233	56232453
Cannabinoid hyperemesis syndrome	18.68	15.79	5	55376	40	56236646
Pain in jaw	18.65	15.79	8	55373	40028	56196658
Cerebral salt-wasting syndrome	18.57	15.79	5	55376	41	56236645
Dry eye	18.54	15.79	6	55375	35710	56200976
Gastroenteritis radiation	18.42	15.79	9	55372	448	56236238
Mucosal erosion	18.33	15.79	13	55368	1298	56235388
Sweat gland tumour	18.31	15.79	6	55375	102	56236584
Hypoacusis	18.30	15.79	55	55326	21713	56214973
Gastric disorder	18.29	15.79	5	55376	33205	56203481
Blood pressure increased	18.29	15.79	77	55304	145099	56091587
Pelvic fluid collection	18.29	15.79	11	55370	830	56235856
Muscular weakness	18.25	15.79	48	55333	104404	56132282
Sinus tachycardia	18.21	15.79	56	55325	22388	56214298
Hypoglycaemia	17.99	15.79	17	55364	55798	56180888
Proctitis	17.98	15.79	17	55364	2543	56234143
Cerebral ischaemia	17.96	15.79	26	55355	6124	56230562
Uterine atrophy	17.87	15.79	5	55376	48	56236638
Road traffic accident	17.84	15.79	3	55378	27924	56208762
Urinary tract toxicity	17.78	15.79	3	55378	0	56236686
Emphysematous cholecystitis	17.78	15.79	3	55378	0	56236686
Hypoglossal nerve paresis	17.74	15.79	6	55375	113	56236573
Multiple sclerosis	17.73	15.79	3	55378	27799	56208887
Metastases to pleura	17.71	15.79	13	55368	1369	56235317
Tumour thrombosis	17.70	15.79	4	55377	14	56236672
Transdifferentiation of neoplasm	17.70	15.79	4	55377	14	56236672
Osteoradionecrosis	17.59	15.79	6	55375	116	56236570
Ovarian disorder	17.54	15.79	10	55371	683	56236003
Bursitis	17.53	15.79	3	55378	27579	56209107
Aorto-oesophageal fistula	17.48	15.79	4	55377	15	56236671
Central obesity	17.46	15.79	12	55369	1139	56235547
Roseolovirus test positive	17.42	15.79	5	55376	53	56236633
Tearfulness	17.42	15.79	20	55361	3748	56232938
Neuroblastoma	17.40	15.79	6	55375	120	56236566
Neurosensory hypoacusis	17.34	15.79	7	55374	220	56236466
Necrosis	17.34	15.79	23	55358	4993	56231693
Cardiopulmonary failure	17.24	15.79	19	55362	3406	56233280
Staphylococcal infection	17.18	15.79	78	55303	37540	56199146
Urogenital disorder	17.09	15.79	5	55376	57	56236629
Liver abscess	17.08	15.79	17	55364	2709	56233977
Ovarian failure	16.96	15.79	12	55369	1193	56235493
Deafness neurosensory	16.95	15.79	22	55359	4676	56232010
Abdominal compartment syndrome	16.84	15.79	9	55372	541	56236145
Necrotising colitis	16.81	15.79	9	55372	543	56236143
Chronic obstructive pulmonary disease	16.80	15.79	19	55362	57396	56179290
Melanosis	16.72	15.79	4	55377	19	56236667
Blood culture positive	16.70	15.79	21	55360	4325	56232361
Confusional state	16.69	15.79	128	55253	208027	56028659
Renal tubular dysfunction	16.63	15.79	8	55373	385	56236301
Joint stiffness	16.62	15.79	7	55374	35418	56201268
Tumour invasion	16.58	15.79	6	55375	139	56236547
Plasma cell myeloma	16.53	15.79	90	55291	46556	56190130
Blood phosphorus decreased	16.47	15.79	20	55361	3977	56232709
Lip swelling	16.39	15.79	3	55378	26269	56210417
Clostridium difficile colitis	16.38	15.79	48	55333	18690	56217996
Myasthenic syndrome	16.37	15.79	7	55374	255	56236431
Eye pain	16.34	15.79	5	55376	30842	56205844
Fanconi syndrome	16.29	15.79	12	55369	1271	56235415
Stent malfunction	16.29	15.79	5	55376	68	56236618
Pseudomonal sepsis	16.29	15.79	15	55366	2171	56234515
Tracheal stenosis	16.23	15.79	6	55375	148	56236538
Systemic infection	16.22	15.79	18	55363	3251	56233435
Sedation	16.17	15.79	7	55374	34847	56201839
Throat irritation	16.09	15.79	6	55375	32677	56204009
Neuromyopathy	16.07	15.79	9	55372	594	56236092
Surgery	15.93	15.79	6	55375	32480	56204206
Metastases to retroperitoneum	15.86	15.79	6	55375	158	56236528
Hypoxia	15.86	15.79	99	55282	53798	56182888
Skin toxicity	15.85	15.79	20	55361	4133	56232553
Therapy interrupted	15.83	15.79	3	55378	25622	56211064

FDA Adverse Event Reporting System (Male)

MedDRA adverse event term	Likelihood ratio	Likelihood ratio threshold	Patients taking drug having adverse event	Patients taking drug not having adverse event	Patients not taking drug having adverse event	Patients not taking drug not having adverse event
Febrile neutropenia	1406.68	13.19	1629	78290	120220	31497205
Neutropenia	926.67	13.19	1429	78490	138935	31478490
Mucosal inflammation	761.65	13.19	657	79262	33770	31583655
Thrombocytopenia	552.10	13.19	1152	78767	141595	31475830
Malignant neoplasm progression	486.07	13.19	780	79139	78218	31539207
Pancytopenia	414.89	13.19	769	79150	86547	31530878
Disease progression	394.32	13.19	768	79151	89696	31527729
Dehydration	359.89	13.19	872	79047	118239	31499186
Bone marrow failure	352.87	13.19	393	79526	27615	31589810
Leukopenia	341.81	13.19	561	79358	57267	31560158
Myelosuppression	340.31	13.19	290	79629	14630	31602795
Vomiting	295.01	13.19	1230	78689	222743	31394682
Haematotoxicity	280.73	13.19	192	79727	6945	31610480
Stomatitis	275.14	13.19	413	79506	39025	31578400
Neutropenic sepsis	260.84	13.19	230	79689	12149	31605276
Dysphagia	247.76	13.19	487	79432	57189	31560236
Nausea	241.36	13.19	1460	78459	306487	31310938
Neoplasm progression	239.18	13.19	275	79644	19997	31597428
Acute myeloid leukaemia	228.25	13.19	258	79661	18414	31599011
Anaemia	222.03	13.19	1094	78825	212428	31404997
Second primary malignancy	207.65	13.19	159	79760	6873	31610552
Drug abuse	205.66	13.19	3	79916	87755	31529670
Neutrophil count decreased	204.37	13.19	396	79523	45998	31571427
Product dose omission issue	202.84	13.19	17	79902	105569	31511856
Arthralgia	180.49	13.19	78	79841	151346	31466079
Pulmonary embolism	177.74	13.19	530	79389	81116	31536309
Off label use	172.11	13.19	1475	78444	345799	31271626
Therapy partial responder	171.36	13.19	138	79781	6424	31611001
Aortic thrombosis	170.30	13.19	65	79854	645	31616780
Nephropathy toxic	168.79	13.19	174	79745	11179	31606246
Fall	167.97	13.19	134	79785	185955	31431470
Renal salt-wasting syndrome	154.41	13.19	48	79871	237	31617188
Myelodysplastic syndrome	147.77	13.19	211	79708	19040	31598385
Drug interaction	137.07	13.19	196	79723	208347	31409078
Pyrexia	136.60	13.19	1264	78655	302576	31314849
Cardiotoxicity	131.86	13.19	106	79813	4921	31612504
Decreased appetite	131.40	13.19	745	79174	152472	31464953
Ototoxicity	127.63	13.19	70	79849	1688	31615737
Tumour lysis syndrome	123.07	13.19	172	79747	15213	31602212
Overdose	115.38	13.19	35	79884	84629	31532796
Hyponatraemia	114.96	13.19	428	79491	73371	31544054
Diffuse large B-cell lymphoma refractory	112.90	13.19	55	79864	1028	31616397
Headache	109.72	13.19	184	79735	183468	31433957
Septic shock	109.21	13.19	391	79528	65767	31551658
White blood cell count decreased	107.53	13.19	471	79448	86927	31530498
Diffuse large B-cell lymphoma recurrent	107.52	13.19	76	79843	2899	31614526
Hypomagnesaemia	105.88	13.19	180	79739	18878	31598547
Anastomotic leak	104.56	13.19	44	79875	574	31616851
Weight increased	101.51	13.19	41	79878	82906	31534519
Oesophagitis	101.08	13.19	140	79779	12276	31605149
Acute kidney injury	98.37	13.19	1107	78812	278607	31338818
Rhabdomyolysis	94.73	13.19	22	79897	63559	31553866
Arterial thrombosis	94.59	13.19	54	79865	1410	31616015
Depression	94.30	13.19	56	79863	90759	31526666
Febrile bone marrow aplasia	93.45	13.19	107	79812	7739	31609686
Cardiac failure congestive	92.74	13.19	42	79877	79345	31538080
Psoriasis	91.11	13.19	7	79912	46712	31570713
Rheumatoid arthritis	90.92	13.19	8	79911	47801	31569624
Hypophagia	90.77	13.19	183	79736	21859	31595566
Aorto-oesophageal fistula	90.42	13.19	22	79897	31	31617394
Radiation skin injury	89.96	13.19	41	79878	655	31616770
Metastases to lung	88.94	13.19	108	79811	8314	31609111
Deafness	88.20	13.19	120	79799	10345	31607080
Tinnitus	86.84	13.19	151	79768	16124	31601301
Muscle spasms	86.51	13.19	32	79887	68286	31549139
Odynophagia	84.28	13.19	82	79837	4911	31612514
Hospitalisation	83.18	13.19	13	79906	49794	31567631
Peripheral swelling	82.29	13.19	34	79885	67831	31549594
Sepsis	81.52	13.19	658	79261	151271	31466154
Anxiety	81.43	13.19	66	79853	90967	31526458
Inappropriate antidiuretic hormone secretion	80.39	13.19	120	79799	11267	31606158
Osteoradionecrosis	80.11	13.19	22	79897	63	31617362
Gastric perforation	80.06	13.19	58	79861	2301	31615124
Platelet count decreased	79.88	13.19	514	79405	109921	31507504
Metastases to central nervous system	79.15	13.19	97	79822	7539	31609886
Intentional product misuse	79.04	13.19	4	79915	37947	31579478
Suicide attempt	77.34	13.19	4	79915	37244	31580181
Peripheral ischaemia	76.55	13.19	80	79839	5220	31612205
Vena cava thrombosis	75.90	13.19	42	79877	1031	31616394
Musculoskeletal stiffness	75.72	13.19	8	79911	41317	31576108
Insomnia	75.03	13.19	77	79842	94759	31522666
Joint swelling	74.77	13.19	21	79898	53410	31564015
Asthma	73.75	13.19	10	79909	42601	31574824
Product use in unapproved indication	73.20	13.19	464	79455	98707	31518718
Nasopharyngitis	73.01	13.19	34	79885	63211	31554214
Suicidal ideation	72.29	13.19	5	79914	36401	31581024
Peripheral artery thrombosis	71.93	13.19	53	79866	2159	31615266
Myalgia	71.64	13.19	54	79865	77204	31540221
Pneumonitis	71.40	13.19	204	79715	30448	31586977
Osteosarcoma	71.18	13.19	27	79892	263	31617162
Blood pressure increased	69.65	13.19	59	79860	79574	31537851
Oesophageal fistula	68.95	13.19	25	79894	212	31617213
Pain in extremity	67.86	13.19	118	79801	116085	31501340
Neutropenic colitis	66.88	13.19	55	79864	2637	31614788
Hypokalaemia	66.80	13.19	290	79629	53284	31564141
Inappropriate schedule of product administration	65.70	13.19	23	79896	50800	31566625
Aplasia	65.34	13.19	66	79853	4137	31613288
Gastrointestinal toxicity	64.03	13.19	50	79869	2224	31615201
Splenic infarction	62.42	13.19	46	79873	1874	31615551
Deafness neurosensory	62.32	13.19	53	79866	2663	31614762
Bacterial translocation	61.27	13.19	25	79894	300	31617125
Condition aggravated	60.81	13.19	211	79708	163798	31453627
Renal failure	60.69	13.19	524	79395	122806	31494619
General physical health deterioration	60.62	13.19	491	79428	112944	31504481
Dermatitis	60.16	13.19	90	79829	8466	31608959
Prostate cancer	60.16	13.19	11	79908	37590	31579835
Death	59.97	13.19	601	79318	359968	31257457
Injection site pain	57.91	13.19	9	79910	34625	31582800
Metastases to liver	57.64	13.19	110	79809	12617	31604808
Cardiac disorder	57.55	13.19	14	79905	39200	31578225
Dizziness	57.15	13.19	283	79636	198864	31418561
Radiation pneumonitis	56.71	13.19	48	79871	2396	31615029
Portal venous gas	55.83	13.19	24	79895	331	31617094
Aggression	55.34	13.19	13	79906	37278	31580147
Wheezing	54.50	13.19	12	79907	35974	31581451
Hypertension	54.36	13.19	155	79764	127945	31489480
Oesophagobronchial fistula	53.25	13.19	19	79900	153	31617272
Heart rate decreased	53.01	13.19	5	79914	28261	31589164
Pruritus	52.71	13.19	152	79767	125015	31492410
COVID-19	52.52	13.19	37	79882	54784	31562641
Hiccups	51.95	13.19	88	79831	9199	31608226
Hypocalcaemia	51.88	13.19	147	79772	21831	31595594
Malignant transformation	51.75	13.19	30	79889	807	31616618
Tumour necrosis	51.62	13.19	34	79885	1153	31616272
Thrombotic microangiopathy	51.51	13.19	88	79831	9263	31608162
Renal impairment	51.23	13.19	383	79536	85966	31531459
Radiation oesophagitis	51.10	13.19	24	79895	412	31617013
Atypical haemolytic uraemic syndrome	51.06	13.19	20	79899	214	31617211
Tremor	50.89	13.19	71	79848	76349	31541076
Colitis	50.60	13.19	194	79725	33693	31583732
Hepatitis B	49.79	13.19	67	79852	5714	31611711
Gait disturbance	49.63	13.19	74	79845	77421	31540004
Blood creatine phosphokinase increased	49.32	13.19	22	79897	41952	31575473
Vision blurred	49.20	13.19	22	79897	41893	31575532
Salivary gland cancer	49.02	13.19	21	79898	287	31617138
Hallucination	49.02	13.19	28	79891	46382	31571043
Electrolyte imbalance	48.98	13.19	100	79819	12048	31605377
Oesophageal stenosis	48.87	13.19	37	79882	1571	31615854
Pulmonary vascular disorder	48.58	13.19	26	79893	596	31616829
Acute respiratory distress syndrome	48.35	13.19	154	79765	24386	31593039
Neuropathy peripheral	48.00	13.19	341	79578	75308	31542117
Influenza	47.89	13.19	26	79893	44299	31573126
Leukoencephalopathy	47.80	13.19	54	79865	3848	31613577
Feeling abnormal	47.70	13.19	44	79875	56958	31560467
Disease recurrence	47.20	13.19	128	79791	18533	31598892
Foetal exposure during pregnancy	47.13	13.19	22	79897	40854	31576571
Respiratory failure	46.25	13.19	424	79495	101025	31516400
Mobility decreased	46.24	13.19	7	79912	27462	31589963
B-cell lymphoma recurrent	46.13	13.19	26	79893	662	31616763
Ameloblastoma	45.96	13.19	15	79904	89	31617336
Bacteraemia	45.65	13.19	122	79797	17512	31599913
Coronary artery disease	45.62	13.19	30	79889	46057	31571368
Wrong technique in product usage process	45.00	13.19	14	79905	33329	31584096
Deep vein thrombosis	44.66	13.19	284	79635	60452	31556973
Renal tubular disorder	44.06	13.19	55	79864	4355	31613070
Somnolence	43.91	13.19	118	79801	99327	31518098
Metastases to lymph nodes	43.88	13.19	54	79865	4214	31613211
Arthritis	43.83	13.19	8	79911	27377	31590048
Azoospermia	43.52	13.19	21	79898	384	31617041
Carotid artery thrombosis	43.25	13.19	20	79899	331	31617094
Renal infarct	42.98	13.19	31	79888	1221	31616204
Urticaria	42.91	13.19	49	79870	57468	31559957
Blood pressure fluctuation	42.69	13.19	4	79915	22732	31594693
Intestinal ischaemia	42.41	13.19	69	79850	6976	31610449
Cytomegalovirus oesophagitis	42.38	13.19	22	79897	473	31616952
Drug hypersensitivity	42.10	13.19	74	79845	72525	31544900
Enteritis	42.02	13.19	69	79850	7030	31610395
Neoplasm recurrence	41.98	13.19	38	79881	2076	31615349
Memory impairment	41.73	13.19	22	79897	38108	31579317
Therapeutic product effect decreased	41.40	13.19	14	79905	31608	31585817
Angioedema	40.48	13.19	17	79902	33601	31583824
Incorrect dose administered	40.06	13.19	20	79899	35732	31581693
Lymphopenia	40.02	13.19	102	79817	14227	31603198
Pulmonary arteriopathy	40.00	13.19	13	79906	76	31617349
Pain	39.07	13.19	293	79626	186466	31430959
Adverse drug reaction	38.98	13.19	8	79911	25193	31592232
Anastomotic complication	38.96	13.19	19	79900	356	31617069
Embolism	38.30	13.19	67	79852	7186	31610239
Pneumatosis intestinalis	38.23	13.19	47	79872	3664	31613761
Bronchial fistula	38.01	13.19	15	79904	164	31617261
Interstitial lung disease	37.90	13.19	275	79644	61128	31556297
Tumour perforation	37.56	13.19	17	79902	267	31617158
Balance disorder	37.53	13.19	24	79895	37398	31580027
Influenza like illness	37.48	13.19	9	79910	25428	31591997
Diarrhoea	37.45	13.19	1157	78762	351252	31266173
Hypoglycaemia	37.36	13.19	44	79875	50902	31566523
Alopecia	37.30	13.19	126	79793	20569	31596856
Blood stem cell transplant failure	37.00	13.19	19	79900	399	31617026
Tumour haemorrhage	36.76	13.19	39	79880	2589	31614836
Chemotherapy	36.72	13.19	21	79898	550	31616875
Radiation mucositis	35.97	13.19	15	79904	191	31617234
Tracheo-oesophageal fistula	35.96	13.19	19	79900	424	31617001
Cataract	35.92	13.19	8	79911	23799	31593626
Electrocardiogram QT prolonged	35.91	13.19	26	79893	37961	31579464
Metastasis	35.89	13.19	45	79874	3579	31613846
Large intestine perforation	35.82	13.19	67	79852	7569	31609856
Blood sodium decreased	35.72	13.19	102	79817	15213	31602212
Product prescribing error	35.47	13.19	4	79915	19638	31597787
Hypoacusis	35.08	13.19	100	79819	14899	31602526
Neurosensory hypoacusis	34.90	13.19	7	79912	0	31617425
Unevaluable event	34.41	13.19	17	79902	30558	31586867
Teratoma	34.39	13.19	9	79910	20	31617405
International normalised ratio increased	34.30	13.19	38	79881	45185	31572240
Abdominal discomfort	34.23	13.19	48	79871	51519	31565906
Osteoarthritis	34.14	13.19	4	79915	19063	31598362
Rash	33.71	13.19	335	79584	201151	31416274
Testicular germ cell cancer metastatic	33.46	13.19	11	79908	67	31617358
Depressed mood	33.25	13.19	3	79916	17572	31599853
Myocardial infarction	33.19	13.19	160	79759	113294	31504131
Empyema	32.95	13.19	39	79880	2922	31614503
Acquired gene mutation	32.85	13.19	27	79892	1293	31616132
Oedema peripheral	32.66	13.19	154	79765	109685	31507740
Nasal congestion	32.51	13.19	6	79913	20375	31597050
Chloroma	32.51	13.19	19	79900	519	31616906
Palmar-plantar erythrodysaesthesia syndrome	32.19	13.19	99	79820	15384	31602041
Blood glucose increased	32.13	13.19	66	79853	61017	31556408
Chronic obstructive pulmonary disease	32.06	13.19	40	79879	45126	31572299
Chest discomfort	31.74	13.19	47	79872	49322	31568103
Recall phenomenon	31.68	13.19	19	79900	545	31616880
Back pain	31.60	13.19	155	79764	109258	31508167
Dyskinesia	31.60	13.19	7	79912	20903	31596522
Progressive multifocal leukoencephalopathy	31.57	13.19	71	79848	9142	31608283
Sedation	31.54	13.19	5	79914	18960	31598465
Pulmonary toxicity	31.47	13.19	52	79867	5325	31612100
Serotonin syndrome	31.11	13.19	5	79914	18768	31598657
Bicytopenia	31.01	13.19	32	79887	2057	31615368
Confusional state	30.89	13.19	203	79716	133131	31484294
Contusion	30.70	13.19	23	79896	33005	31584420
Mantle cell lymphoma recurrent	30.24	13.19	18	79901	509	31616916
Bradycardia	30.03	13.19	83	79836	69244	31548181
Erectile dysfunction	29.97	13.19	6	79913	19229	31598196
Gout	29.76	13.19	5	79914	18169	31599256
Osteosarcoma recurrent	29.63	13.19	8	79911	21	31617404
Blood HIV RNA increased	29.61	13.19	24	79895	1127	31616298
Nephrolithiasis	29.58	13.19	16	79903	27323	31590102
Papillary thyroid cancer	29.58	13.19	19	79900	617	31616808
Toxicity to various agents	29.42	13.19	304	79615	181183	31436242
Hyperammonaemic encephalopathy	29.32	13.19	32	79887	2194	31615231
Pharyngeal inflammation	29.17	13.19	15	79904	316	31617109
Injury	28.98	13.19	7	79912	19702	31597723
Primitive neuroectodermal tumour	28.76	13.19	10	79909	74	31617351
Malaise	28.66	13.19	279	79640	168232	31449193
Blood creatinine increased	28.64	13.19	347	79572	88731	31528694
Arterial occlusive disease	28.57	13.19	43	79876	4066	31613359
Liver function test abnormal	28.48	13.19	20	79899	29672	31587753
Radiation injury	28.46	13.19	17	79902	484	31616941
Pancreatitis	28.31	13.19	29	79890	35742	31581683
Disseminated intravascular coagulation	27.77	13.19	114	79805	20423	31597002
Gait inability	27.76	13.19	7	79912	19137	31598288
Drug resistance	27.73	13.19	125	79794	23328	31594097
Sleep disorder	27.67	13.19	16	79903	26332	31591093
Hepatic candidiasis	27.49	13.19	9	79910	54	31617371
Peritonitis	27.34	13.19	93	79826	15234	31602191
Metastatic gastric cancer	27.25	13.19	12	79907	176	31617249
Abnormal behaviour	27.19	13.19	13	79906	23815	31593610
Drug ineffective	27.18	13.19	775	79144	394798	31222627
Plasma cell leukaemia	26.97	13.19	21	79898	930	31616495
Cystitis haemorrhagic	26.82	13.19	48	79871	5241	31612184
Sinusitis	26.57	13.19	32	79887	36664	31580761
Extravasation	26.43	13.19	27	79892	1715	31615710
Cytopenia	26.33	13.19	74	79845	10936	31606489
Hypophosphataemia	26.31	13.19	63	79856	8451	31608974
Fluid retention	26.13	13.19	15	79904	24787	31592638
Flagellate dermatitis	26.07	13.19	9	79910	65	31617360
Accidental overdose	26.06	13.19	7	79912	18343	31599082
Enterocolitis	25.99	13.19	57	79862	7217	31610208
Angina pectoris	25.85	13.19	22	79897	29619	31587806
Non-small cell lung cancer	25.77	13.19	41	79878	4068	31613357
Emotional distress	25.73	13.19	3	79916	14353	31603072
Localised infection	25.44	13.19	4	79915	15261	31602164
Product administration error	25.40	13.19	4	79915	15243	31602182
Irritability	25.35	13.19	13	79906	22876	31594549
Blindness cortical	25.32	13.19	14	79905	343	31617082
Cerebral ischaemia	25.17	13.19	50	79869	5905	31611520
Oral candidiasis	25.08	13.19	73	79846	11004	31606421
Dermatitis acneiform	25.08	13.19	49	79870	5718	31611707
Muscular weakness	25.02	13.19	83	79836	65365	31552060
Diabetes mellitus	25.00	13.19	43	79876	42513	31574912
Therapy cessation	24.97	13.19	4	79915	15051	31602374
Agitation	24.86	13.19	63	79856	54106	31563319
Blood cholesterol increased	24.84	13.19	6	79913	16887	31600538
Blood pressure systolic increased	24.83	13.19	9	79910	19461	31597964
Hepatitis B reactivation	24.72	13.19	37	79882	3481	31613944
Adenocarcinoma gastric	24.55	13.19	22	79897	1186	31616239
Cerebral venous sinus thrombosis	24.53	13.19	15	79904	446	31616979
Pleural mesothelioma malignant	24.45	13.19	9	79910	80	31617345
Refeeding syndrome	24.32	13.19	7	79912	25	31617400
Neurotoxicity	24.30	13.19	93	79826	16133	31601292
Superior mesenteric artery syndrome	24.25	13.19	9	79910	82	31617343
EGFR gene mutation	24.07	13.19	10	79909	126	31617299
Granulocyte count decreased	24.06	13.19	17	79902	648	31616777
Testicular malignant teratoma	24.05	13.19	6	79913	10	31617415
Lactic acidosis	24.04	13.19	27	79892	31910	31585515
Gastrooesophageal reflux disease	24.03	13.19	30	79889	33841	31583584
Lymphadenopathy mediastinal	24.03	13.19	29	79890	2217	31615208
Cerebral infarction	23.96	13.19	129	79790	25848	31591577
Cerebral venous thrombosis	23.87	13.19	17	79902	656	31616769
Pneumothorax	23.77	13.19	95	79824	16815	31600610
Road traffic accident	23.74	13.19	6	79913	16375	31601050
Loss of personal independence in daily activities	23.46	13.19	22	79897	28266	31589159
Small cell lung cancer	23.14	13.19	26	79893	1841	31615584
Refractory cancer	23.13	13.19	10	79909	140	31617285
Sleep apnoea syndrome	23.10	13.19	9	79910	18616	31598809
Gene mutation	23.05	13.19	21	79898	1157	31616268
Blood lactate dehydrogenase increased	23	13.19	107	79812	20232	31597193
Labelled drug-drug interaction medication error	22.98	13.19	3	79916	13160	31604265
Retinal toxicity	22.84	13.19	14	79905	418	31617007
Haematochezia	22.77	13.19	42	79877	40422	31577003
Arteriospasm coronary	22.63	13.19	32	79887	2859	31614566
Diaphragm muscle weakness	22.63	13.19	10	79909	148	31617277
Diffuse large B-cell lymphoma	22.58	13.19	60	79859	8581	31608844
Myoclonus	22.57	13.19	4	79915	13986	31603439
Procedural vomiting	22.51	13.19	10	79909	150	31617275
Wound	22.44	13.19	3	79916	12925	31604500
Paraneoplastic syndrome	22.43	13.19	15	79904	522	31616903
Necrosis	22.30	13.19	44	79875	5172	31612253
Metastases to peritoneum	22.10	13.19	24	79895	1636	31615789
Oesophageal perforation	22.06	13.19	19	79900	971	31616454
Granulocyte-colony stimulating factor level increased	22.00	13.19	5	79914	4	31617421
Lung adenocarcinoma	22.00	13.19	40	79879	4422	31613003
Procedural nausea	21.94	13.19	8	79911	69	31617356
Embolism arterial	21.88	13.19	15	79904	544	31616881
Morphoea	21.87	13.19	10	79909	161	31617264
Hypochloraemia	21.69	13.19	15	79904	552	31616873
Cholelithiasis	21.66	13.19	11	79908	19468	31597957
Gastrointestinal ischaemia	21.60	13.19	10	79909	166	31617259
Necrosis ischaemic	21.51	13.19	11	79908	229	31617196
Hot flush	21.50	13.19	7	79912	16189	31601236
Polyneuropathy	21.48	13.19	77	79842	12945	31604480
Psychotic disorder	21.40	13.19	15	79904	22278	31595147
Blood glucose decreased	21.40	13.19	3	79916	12468	31604957
Deafness bilateral	21.36	13.19	19	79900	1014	31616411
Pleural effusion	21.17	13.19	285	79634	74635	31542790
Coronary artery thrombosis	21.14	13.19	26	79893	2027	31615398
Tumour thrombosis	21.08	13.19	8	79911	78	31617347
Herpes zoster	21.01	13.19	30	79889	31963	31585462
Soft tissue disorder	20.96	13.19	16	79903	688	31616737
Upper respiratory tract infection	20.94	13.19	26	79893	29396	31588029
Hyperhidrosis	20.90	13.19	93	79826	67300	31550125
Adenoviral hepatitis	20.79	13.19	14	79905	493	31616932
Performance status decreased	20.71	13.19	36	79883	3842	31613583
Mitral valve incompetence	20.60	13.19	5	79914	14028	31603397
Immune-mediated dermatitis	20.57	13.19	10	79909	186	31617239
Vascular injury	20.37	13.19	11	79908	257	31617168
Metastases to skin	20.27	13.19	13	79906	421	31617004
Neutrophil count abnormal	20.13	13.19	23	79896	1659	31615766
Arteritis	20.01	13.19	12	79907	344	31617081
Swelling	19.95	13.19	40	79879	37318	31580107
Speech disorder	19.86	13.19	19	79900	24182	31593243
Product quality issue	19.63	13.19	8	79911	16103	31601322
Transient ischaemic attack	19.61	13.19	19	79900	24037	31593388
Adrenocortical carcinoma	19.58	13.19	6	79913	28	31617397
Failure to thrive	19.52	13.19	54	79865	7908	31609517
Underdose	19.50	13.19	4	79915	12603	31604822
Extremity necrosis	19.46	13.19	23	79896	1720	31615705
Campylobacter test positive	19.41	13.19	6	79913	29	31617396
Carotid artery dissection	19.40	13.19	9	79910	150	31617275
Bronchitis	19.38	13.19	43	79876	38674	31578751
Palpitations	19.37	13.19	36	79883	34547	31582878
Loss of consciousness	19.33	13.19	115	79804	77240	31540185
B-cell lymphoma refractory	19.30	13.19	9	79910	152	31617273
Accidental exposure to product	19.18	13.19	3	79916	11492	31605933
Disturbance in attention	19.17	13.19	17	79902	22433	31594992
Transitional cell carcinoma recurrent	19.14	13.19	5	79914	11	31617414
Cell-mediated immune deficiency	19.08	13.19	6	79913	31	31617394
Peritoneal lesion	19.03	13.19	8	79911	104	31617321
Visual impairment	18.93	13.19	31	79888	31248	31586177
Full blood count decreased	18.91	13.19	9	79910	16531	31600894
Laryngeal pain	18.90	13.19	28	79891	2610	31614815
Hypoaesthesia	18.80	13.19	75	79844	55947	31561478
Peripheral sensory neuropathy	18.73	13.19	46	79873	6269	31611156
Iliac artery occlusion	18.73	13.19	9	79910	163	31617262
Hyperlipidaemia	18.72	13.19	5	79914	13155	31604270
Haematoma	18.62	13.19	20	79899	24119	31593306
Medulloblastoma recurrent	18.56	13.19	7	79912	67	31617358
Osteosarcoma metastatic	18.56	13.19	5	79914	13	31617412
Metastases to chest wall	18.53	13.19	9	79910	167	31617258
Gastrointestinal perforation	18.47	13.19	33	79886	3599	31613826
Intestinal infarction	18.43	13.19	13	79906	494	31616931
Seminoma	18.42	13.19	10	79909	236	31617189
Transformation to acute myeloid leukaemia	18.26	13.19	15	79904	718	31616707
Delusion	18.16	13.19	4	79915	11993	31605432
Movement disorder	18.11	13.19	3	79916	11016	31606409
Visceral venous thrombosis	18.03	13.19	5	79914	15	31617410
Hypoalbuminaemia	18.01	13.19	65	79854	10963	31606462
Injection site erythema	17.92	13.19	7	79912	14455	31602970
Hepatic enzyme increased	17.88	13.19	40	79879	35868	31581557
Burning sensation	17.83	13.19	10	79909	16737	31600688
Urinary tract infection	17.80	13.19	117	79802	76752	31540673
Metastases to bone	17.77	13.19	64	79855	10784	31606641
Metastases to meninges	17.68	13.19	19	79900	1280	31616145
Rectal haemorrhage	17.62	13.19	41	79878	36263	31581162
Withdrawal syndrome	17.55	13.19	4	79915	11713	31605712
Drug clearance decreased	17.50	13.19	21	79898	1596	31615829
Pneumonia adenoviral	17.49	13.19	11	79908	344	31617081
Dermatitis diaper	17.31	13.19	10	79909	267	31617158
Swelling face	17.31	13.19	17	79902	21373	31596052
Candida infection	17.27	13.19	84	79835	16174	31601251
Drug intolerance	17.24	13.19	70	79849	51963	31565462
Traumatic lung injury	17.24	13.19	18	79901	1173	31616252
Meningitis tuberculous	17.22	13.19	14	79905	660	31616765
Trigeminal nerve paresis	17.18	13.19	4	79915	4	31617421
Spinal column injury	17.17	13.19	13	79906	552	31616873
Oesophageal pain	17.16	13.19	15	79904	782	31616643
BK virus infection	17.16	13.19	39	79880	5056	31612369
Venous thrombosis	17.10	13.19	30	79889	3225	31614200
Colitis ulcerative	17.10	13.19	13	79906	18516	31598909
Gingivitis ulcerative	17.07	13.19	6	79913	46	31617379
Fanconi syndrome	17.04	13.19	21	79898	1641	31615784
Gastrointestinal anastomotic leak	17.02	13.19	11	79908	361	31617064
Dementia	17.02	13.19	5	79914	12355	31605070
Infected neoplasm	17.01	13.19	7	79912	86	31617339
Chemotherapeutic drug level increased	16.99	13.19	9	79910	202	31617223
Type 2 diabetes mellitus	16.97	13.19	8	79911	14776	31602649
Blood creatinine	16.96	13.19	6	79913	47	31617378
Human chorionic gonadotropin increased	16.93	13.19	5	79914	20	31617405
Eye pain	16.90	13.19	5	79914	12299	31605126
Hepatic steatosis	16.85	13.19	10	79909	16229	31601196
Laryngeal inflammation	16.74	13.19	5	79914	21	31617404
Immune-mediated hepatic disorder	16.65	13.19	13	79906	578	31616847
Chondrosarcoma	16.64	13.19	6	79913	50	31617375
Blister	16.53	13.19	17	79902	20919	31596506
Haemoptysis	16.44	13.19	138	79781	32051	31585374
Respiratory depression	16.43	13.19	8	79911	14502	31602923
Subcutaneous emphysema	16.42	13.19	17	79902	1097	31616328
Lymphangiosis carcinomatosa	16.27	13.19	15	79904	839	31616586
Hypersomnia	16.25	13.19	4	79915	11115	31606310
Dysstasia	16.25	13.19	4	79915	11114	31606311
Frequent bowel movements	16.18	13.19	3	79916	10156	31607269
Eosinophilia	16.08	13.19	21	79898	23232	31594193
Treatment noncompliance	15.97	13.19	25	79894	25659	31591766
Wound evisceration	15.82	13.19	7	79912	104	31617321
Blood triglycerides increased	15.77	13.19	7	79912	13390	31604035
Ureteric dilatation	15.75	13.19	8	79911	164	31617261
Urine sodium increased	15.68	13.19	6	79913	60	31617365
Rib fracture	15.60	13.19	7	79912	13309	31604116
Ganglioneuroma	15.57	13.19	4	79915	8	31617417
Extragonadal primary germ cell tumour mixed	15.57	13.19	4	79915	8	31617417
Chromaturia	15.57	13.19	7	79912	13291	31604134
Lymphadenopathy	15.54	13.19	116	79803	26005	31591420
Myelitis transverse	15.47	13.19	16	79903	1031	31616394
White blood cell disorder	15.44	13.19	19	79900	1482	31615943
Testicular cancer metastatic	15.42	13.19	6	79913	63	31617362
Mucosal toxicity	15.39	13.19	9	79910	246	31617179
Agranulocytosis	15.38	13.19	99	79820	21148	31596277
Choriocarcinoma	15.27	13.19	5	79914	30	31617395
Nasal sinus cancer	15.27	13.19	5	79914	30	31617395
Osteomyelitis	15.22	13.19	9	79910	14634	31602791
Laboratory test abnormal	15.17	13.19	15	79904	18799	31598626
Plasmacytoma	15.06	13.19	29	79890	3348	31614077
Paranoia	15.04	13.19	4	79915	10551	31606874
Head injury	14.97	13.19	12	79907	16646	31600779
Pharyngeal stenosis	14.96	13.19	3	79916	0	31617425
Carotid artery perforation	14.96	13.19	3	79916	0	31617425
Salivary gland cancer recurrent	14.96	13.19	3	79916	0	31617425
Evans syndrome	14.80	13.19	9	79910	265	31617160
Gastrointestinal haemorrhage	14.72	13.19	135	79784	82414	31535011
Seizure	14.59	13.19	171	79748	99597	31517828
Bone sarcoma	14.56	13.19	6	79913	74	31617351
Aortitis	14.48	13.19	10	79909	367	31617058
Metapneumovirus bronchiolitis	14.43	13.19	4	79915	12	31617413
Oesophageal squamous cell carcinoma	14.32	13.19	10	79909	374	31617051
Subdural haematoma	14.32	13.19	16	79903	18955	31598470
Thrombocytosis	14.25	13.19	30	79889	3693	31613732
Illness	14.23	13.19	3	79916	9274	31608151
Thrombotic thrombocytopenic purpura	14.22	13.19	28	79891	3285	31614140
Subclavian vein thrombosis	14.19	13.19	14	79905	853	31616572
Hip fracture	14.14	13.19	5	79914	10981	31606444
Malocclusion	14.14	13.19	6	79913	80	31617345
Hyperglycaemic hyperosmolar nonketotic syndrome	14.13	13.19	16	79903	1143	31616282
Renal tubular necrosis	14.09	13.19	74	79845	14685	31602740
Basal cell carcinoma	14.09	13.19	15	79904	18164	31599261
JC virus infection	14.05	13.19	21	79898	1973	31615452
Apparent mineralocorticoid excess	14.04	13.19	5	79914	40	31617385
Eczema	13.99	13.19	11	79908	15406	31602019
Viral load increased	13.94	13.19	22	79897	2167	31615258
Blood magnesium decreased	13.94	13.19	39	79880	5747	31611678
Limb injury	13.94	13.19	4	79915	10037	31607388
Haemoperitoneum	13.92	13.19	19	79900	1642	31615783
Tooth disorder	13.91	13.19	4	79915	10025	31607400
Dropped head syndrome	13.90	13.19	7	79912	141	31617284
Premature baby	13.89	13.19	15	79904	18051	31599374
Cellulitis	13.86	13.19	68	79851	47950	31569475
Platelet transfusion	13.82	13.19	17	79902	1326	31616099
Retinopathy	13.77	13.19	20	79899	1831	31615594
Cardiogenic shock	13.76	13.19	22	79897	22386	31595039
Cerebrovascular accident	13.74	13.19	131	79788	79353	31538072
Chronic hepatitis B	13.73	13.19	5	79914	43	31617382
Enterococcal bacteraemia	13.68	13.19	19	79900	1669	31615756
Dyspnoea exertional	13.67	13.19	51	79868	38786	31578639
Therapeutic embolisation	13.64	13.19	9	79910	306	31617119
Penile vein thrombosis	13.55	13.19	4	79915	16	31617409
Torulopsis infection	13.55	13.19	4	79915	16	31617409
Fistula of small intestine	13.51	13.19	10	79909	410	31617015
Hypovolaemia	13.38	13.19	49	79870	8323	31609102
Sarcoma	13.34	13.19	10	79909	418	31617007
Focal nodular hyperplasia	13.26	13.19	7	79912	156	31617269
Hemianopia	13.25	13.19	12	79907	656	31616769
Heart rate irregular	13.21	13.19	10	79909	14279	31603146
Alpha 1 foetoprotein increased	13.20	13.19	12	79907	659	31616766

FDA Adverse Event Reporting System (Geriatric)

MedDRA adverse event term	Likelihood ratio	Likelihood ratio threshold	Patients taking drug having adverse event	Patients taking drug not having adverse event	Patients not taking drug having adverse event	Patients not taking drug not having adverse event
Febrile neutropenia	2265.46	12.70	2198	115427	202120	70608699
Neutropenia	1670.18	12.70	2090	115535	255066	70555753
Thrombocytopenia	1206.35	12.70	1719	115906	237391	70573428
Mucosal inflammation	1086.50	12.70	900	116725	66950	70743869
Malignant neoplasm progression	1028.65	12.70	1134	116491	120605	70690214
Pancytopenia	818.29	12.70	1125	116500	149982	70660837
Disease progression	804.50	12.70	1137	116488	155535	70655284
Bone marrow failure	773.68	12.70	645	116980	48365	70762454
Haematotoxicity	680.71	12.70	368	117257	13306	70797513
Myelosuppression	636.20	12.70	471	117154	29674	70781145
Anaemia	560.83	12.70	1702	115923	401721	70409098
Leukopenia	537.12	12.70	767	116858	105793	70705026
Acute myeloid leukaemia	502.30	12.70	414	117211	30526	70780293
Dehydration	477.29	12.70	1115	116510	225027	70585792
Arthralgia	476.50	12.70	124	117501	503266	70307553
Vomiting	457.43	12.70	2068	115557	591043	70219776
Rheumatoid arthritis	440.02	12.70	9	117616	291796	70519023
Second primary malignancy	413.23	12.70	262	117363	12789	70798030
Neutropenic sepsis	351.23	12.70	307	117318	24523	70786296
Nausea	347.97	12.70	2506	115119	849582	69961237
Neutrophil count decreased	337.87	12.70	543	117082	83013	70727806
Off label use	331.69	12.70	2234	115391	740826	70069993
Aortic thrombosis	323.78	12.70	115	117510	1448	70809371
Ototoxicity	318.24	12.70	135	117490	2806	70808013
Neoplasm progression	315.25	12.70	382	117243	44846	70765973
Renal salt-wasting syndrome	314.75	12.70	91	117534	552	70810267
Fall	304.19	12.70	180	117445	443916	70366903
Joint swelling	293.66	12.70	37	117588	253174	70557645
Nephropathy toxic	272.12	12.70	234	117391	18280	70792539
Hypomagnesaemia	269.07	12.70	335	117290	40429	70770390
Myelodysplastic syndrome	267.65	12.70	287	117338	29498	70781321
Product dose omission issue	259.01	12.70	29	117596	217439	70593380
Pulmonary embolism	255.69	12.70	699	116926	155168	70655651
Acute kidney injury	242.42	12.70	1478	116147	473146	70337673
Pain	231.70	12.70	432	117193	628384	70182435
Therapy partial responder	230.22	12.70	180	117445	12294	70798525
Pyrexia	227.39	12.70	1751	115874	605201	70205618
Peripheral swelling	225.83	12.70	57	117568	236506	70574313
Drug abuse	224.00	12.70	4	117621	147252	70663567
Tumour lysis syndrome	217.35	12.70	220	117405	21140	70789679
Cardiotoxicity	209.21	12.70	162	117463	10908	70799911
Arthropathy	206.95	12.70	10	117615	150047	70660772
Headache	206.52	12.70	407	117218	579998	70230821
Diffuse large B-cell lymphoma recurrent	205.54	12.70	105	117520	3371	70807448
Sepsis	205.13	12.70	876	116749	243669	70567150
Platelet count decreased	204.16	12.70	705	116920	177517	70633302
Metastases to lung	203.88	12.70	189	117436	16295	70794524
Musculoskeletal stiffness	203.29	12.70	10	117615	147750	70663069
Dysphagia	203.19	12.70	524	117101	112310	70698509
Weight increased	203.12	12.70	74	117551	242257	70568562
Deafness	202.25	12.70	202	117423	19101	70791718
Metastases to central nervous system	192.99	12.70	176	117449	14858	70795961
Decreased appetite	189.50	12.70	1001	116624	303779	70507040
Nasopharyngitis	184.28	12.70	69	117556	222137	70588682
Septic shock	179.58	12.70	499	117126	111759	70699060
Posterior reversible encephalopathy syndrome	174.73	12.70	209	117416	24193	70786626
Abdominal discomfort	172.48	12.70	70	117555	214588	70596231
Drug hypersensitivity	170.31	12.70	113	117512	262346	70548473
Anastomotic leak	169.69	12.70	64	117561	965	70809854
Pain in extremity	167.77	12.70	178	117447	327904	70482915
Hyponatraemia	167.65	12.70	615	117010	159472	70651347
Therapeutic product effect decreased	165.47	12.70	21	117604	142997	70667822
Hypokalaemia	165.29	12.70	536	117089	130652	70680167
Teratoma	163.37	12.70	42	117583	150	70810669
White blood cell count decreased	161.15	12.70	633	116992	169508	70641311
Tinnitus	158.46	12.70	244	117381	35932	70774887
Stomatitis	153.79	12.70	516	117109	127995	70682824
Product use in unapproved indication	151.17	12.70	713	116912	206765	70604054
Overdose	150.60	12.70	47	117578	169698	70641121
Systemic lupus erythematosus	150.13	12.70	4	117621	101898	70708921
Oesophagitis	149.20	12.70	186	117439	22466	70788353
Asthma	144.03	12.70	16	117609	120777	70690042
Renal failure	143.80	12.70	658	116967	188412	70622407
Swelling	142.71	12.70	67	117558	188472	70622347
Injection site pain	141.71	12.70	15	117610	117604	70693215
Drug resistance	140.54	12.70	238	117387	37952	70772867
Ovarian germ cell teratoma	139.63	12.70	33	117592	74	70810745
Radiation skin injury	139.00	12.70	60	117565	1303	70809516
Insomnia	138.29	12.70	96	117529	217710	70593109
Pruritus	137.29	12.70	226	117399	345334	70465485
Condition aggravated	135.17	12.70	320	117305	427315	70383504
Diffuse large B-cell lymphoma refractory	131.88	12.70	57	117568	1242	70809577
Neuropathy peripheral	131.55	12.70	486	117139	126410	70684409
Psoriasis	131.21	12.70	8	117617	98425	70712394
Oesophageal fistula	130.93	12.70	41	117584	338	70810481
Inappropriate antidiuretic hormone secretion	129.71	12.70	176	117449	23100	70787719
Metastases to liver	128.31	12.70	185	117440	25693	70785126
Muscle spasms	127.40	12.70	48	117577	153998	70656821
Gastrointestinal toxicity	125.99	12.70	96	117529	6309	70804510
Contraindicated product administered	125.40	12.70	34	117591	134578	70676241
Hypocalcaemia	125.13	12.70	248	117377	44611	70766208
Arthritis	124.71	12.70	10	117615	97970	70712849
Pemphigus	123.30	12.70	3	117622	83033	70727786
Febrile bone marrow aplasia	122.89	12.70	124	117501	11867	70798952
Osteosarcoma	121.80	12.70	40	117585	390	70810429
Hypophagia	121.03	12.70	234	117391	41336	70769483
Wound	120.47	12.70	12	117613	98720	70712099
Contusion	119.91	12.70	32	117593	128004	70682815
Renal impairment	118.50	12.70	513	117112	143424	70667395
Peripheral artery thrombosis	118.33	12.70	71	117554	3136	70807683
Metastases to lymph nodes	116.33	12.70	107	117518	9131	70801688
Disease recurrence	112.33	12.70	214	117411	37389	70773430
Depression	112.01	12.70	99	117526	198875	70611944
Sinusitis	110.84	12.70	72	117553	169123	70641696
Aorto-oesophageal fistula	110.73	12.70	26	117599	56	70810763
Intentional product misuse	107.52	12.70	6	117619	79589	70731230
Gastric perforation	107.02	12.70	71	117554	3744	70807075
Deep vein thrombosis	105.77	12.70	414	117211	110628	70700191
Palmar-plantar erythrodysaesthesia syndrome	105.38	12.70	184	117441	30063	70780756
Leukoencephalopathy	104.76	12.70	91	117534	7203	70803616
Renal tubular disorder	103.82	12.70	84	117541	6026	70804793
Neurotoxicity	103.35	12.70	181	117444	29645	70781174
Pneumonitis	98.66	12.70	254	117371	54343	70756476
Blister	98.24	12.70	23	117602	100503	70710316
Peripheral ischaemia	97.97	12.70	95	117530	8663	70802156
Venoocclusive liver disease	97.86	12.70	104	117521	10574	70800245
Mobility decreased	97.86	12.70	25	117600	102974	70707845
Anxiety	96.20	12.70	135	117490	220195	70590624
Osteoarthritis	95.96	12.70	7	117618	74140	70736679
Rash	94.85	12.70	480	117145	510082	70300737
Odynophagia	94.84	12.70	100	117525	10075	70800744
Hepatic enzyme increased	93.41	12.70	74	117551	156916	70653903
Dizziness	92.21	12.70	426	117199	463715	70347104
Suicidal ideation	91.73	12.70	6	117619	69590	70741229
Arterial thrombosis	91.43	12.70	55	117570	2441	70808378
Urticaria	90.71	12.70	82	117543	162967	70647852
Migraine	90.20	12.70	8	117617	72230	70738589
Hypoacusis	89.99	12.70	162	117463	27107	70783712
Hiccups	89.83	12.70	92	117533	8960	70801859
Gait disturbance	89.50	12.70	105	117520	185001	70625818
Electrolyte imbalance	89.19	12.70	160	117465	26701	70784118
Malignant transformation	88.99	12.70	42	117583	1131	70809688
Dermatitis	87.89	12.70	133	117492	19284	70791535
Drug intolerance	87.33	12.70	150	117475	225537	70585282
Suicide attempt	86.52	12.70	14	117611	79496	70731323
Radiation pneumonitis	85.35	12.70	61	117564	3632	70807187
Discomfort	85.26	12.70	34	117591	105402	70705417
Hospitalisation	84.52	12.70	17	117608	82551	70728268
Drug interaction	84.36	12.70	336	117289	381105	70429714
Blood pressure increased	83.79	12.70	114	117511	188403	70622416
Wheezing	83.63	12.70	26	117599	94144	70716675
Osteoradionecrosis	83.03	12.70	22	117603	91	70810728
Urogenital fistula	82.14	12.70	23	117602	122	70810697
Feeling abnormal	81.06	12.70	70	117555	142249	70668570
Stress	81.01	12.70	9	117616	67957	70742862
Bacteraemia	80.49	12.70	161	117464	29148	70781671
Teratoma benign	80.20	12.70	20	117605	61	70810758
Bronchitis	77.99	12.70	49	117576	117194	70693625
Recall phenomenon	77.53	12.70	37	117588	1022	70809797
Nasal congestion	77.51	12.70	9	117616	65663	70745156
Injury	76.86	12.70	9	117616	65236	70745583
Myalgia	76.16	12.70	100	117525	167792	70643027
Enteritis	76.05	12.70	100	117525	12731	70798088
Acute respiratory distress syndrome	75.64	12.70	193	117432	41061	70769758
Blood creatinine increased	75.60	12.70	450	117175	142551	70668268
Injection site erythema	74.67	12.70	15	117610	72909	70737910
Balance disorder	74.63	12.70	28	117597	90100	70720719
Inappropriate schedule of product administration	74.27	12.70	43	117582	107512	70703307
Thrombotic microangiopathy	73.44	12.70	117	117508	17731	70793088
Infusion related reaction	72.18	12.70	136	117489	197398	70613421
Bicytopenia	71.90	12.70	57	117568	3971	70806848
Colitis	71.69	12.70	251	117374	63563	70747256
Diarrhoea	71.39	12.70	1750	115875	781591	70029228
Somnolence	70.69	12.70	158	117467	215448	70595371
Deafness bilateral	70.58	12.70	43	117582	1953	70808866
Large intestine perforation	69.34	12.70	97	117528	13098	70797721
Loss of personal independence in daily activities	69.27	12.70	27	117598	84883	70725936
Pulmonary vascular disorder	68.83	12.70	33	117592	921	70809898
Radiation oesophagitis	68.70	12.70	29	117596	595	70810224
Drug ineffective	68.27	12.70	1123	116502	938629	69872190
Rhabdomyolysis	67.97	12.70	37	117588	95723	70715096
Respiratory failure	67.94	12.70	496	117129	168239	70642580
Aplasia	67.12	12.70	71	117554	7180	70803639
Fibromyalgia	66.59	12.70	3	117622	47871	70762948
Wrong technique in product usage process	66.56	12.70	16	117609	68682	70742137
Chloroma	66.02	12.70	30	117595	739	70810080
Influenza	65.87	12.70	55	117570	113645	70697174
Hepatitis B	65.62	12.70	74	117551	8040	70802779
Cardiomyopathy	65.50	12.70	139	117486	26234	70784585
Plasma cell leukaemia	65.37	12.70	40	117585	1831	70808988
Cardiac failure congestive	65.29	12.70	77	117548	135380	70675439
Pleural effusion	65.10	12.70	410	117215	132454	70678365
Blood pressure fluctuation	65.09	12.70	10	117615	59002	70751817
Deafness neurosensory	65.08	12.70	67	117558	6565	70804254
Neutropenic colitis	63.94	12.70	59	117566	5055	70805764
Influenza like illness	63.72	12.70	15	117610	65316	70745503
Osteosarcoma metastatic	62.71	12.70	16	117609	55	70810764
Bacterial translocation	62.67	12.70	26	117599	510	70810309
Metastasis	62.24	12.70	63	117562	6051	70804768
Cystitis haemorrhagic	62.17	12.70	74	117551	8519	70802300
Radiation injury	62.13	12.70	29	117596	761	70810058
Renal tubular necrosis	62.09	12.70	126	117499	23045	70787774
Bronchial fistula	61.84	12.70	20	117605	185	70810634
Cytomegalovirus oesophagitis	61.83	12.70	28	117597	684	70810135
Oesophageal stenosis	61.67	12.70	52	117573	3952	70806867
Portal venous gas	60.85	12.70	23	117602	349	70810470
Exposure during pregnancy	60.66	12.70	35	117590	87682	70723137
Atypical haemolytic uraemic syndrome	60.50	12.70	29	117596	809	70810010
Salivary gland cancer	60.05	12.70	24	117601	426	70810393
Injection site swelling	59.07	12.70	3	117622	43154	70767665
Oesophagobronchial fistula	59.07	12.70	20	117605	216	70810603
Hypophosphataemia	59.07	12.70	101	117524	16225	70794594
Heart rate decreased	59.00	12.70	15	117610	62000	70748819
Blood cholesterol increased	58.88	12.70	17	117608	64587	70746232
Acquired gene mutation	58.74	12.70	39	117586	2059	70808760
Metastases to skin	58.53	12.70	35	117590	1536	70809283
Maternal exposure during pregnancy	58.39	12.70	63	117562	115282	70695537
Metastases to bone	57.98	12.70	120	117505	22256	70788563
Osteoporosis	56.98	12.70	7	117618	48900	70761919
Polyneuropathy	56.85	12.70	116	117509	21299	70789520
Disseminated intravascular coagulation	56.30	12.70	152	117473	33446	70777373
Embolism	56.01	12.70	87	117538	12901	70797918
Cataract	55.83	12.70	12	117613	55633	70755186
Metastases to breast	55.72	12.70	20	117605	260	70810559
Pulmonary arteriopathy	55.63	12.70	16	117609	95	70810724
Vena cava thrombosis	55.52	12.70	41	117584	2569	70808250
Type 2 diabetes mellitus	54.71	12.70	5	117620	44075	70766744
Drug clearance decreased	54.56	12.70	43	117582	2970	70807849
Splenic infarction	54.51	12.70	45	117580	3321	70807498
Electrocardiogram QT prolonged	54.04	12.70	36	117589	83481	70727338
Malaise	53.46	12.70	460	117165	432472	70378347
Memory impairment	53.43	12.70	45	117580	92596	70718223
Hypoglycaemia	53.01	12.70	47	117578	94317	70716502
Tumour haemorrhage	52.57	12.70	46	117579	3676	70807143
Vision blurred	52.53	12.70	48	117577	94936	70715883
Interstitial lung disease	52.49	12.70	325	117300	104360	70706459
Tumour necrosis	52.28	12.70	34	117591	1733	70809086
Cytopenia	52.24	12.70	99	117526	17224	70793595
Ameloblastoma	52.16	12.70	15	117610	89	70810730
Renal infarct	52.06	12.70	39	117586	2498	70808321
Lung adenocarcinoma	52.00	12.70	64	117561	7626	70803193
Serotonin syndrome	51.67	12.70	5	117620	42109	70768710
Empyema	50.85	12.70	46	117579	3841	70806978
Adverse drug reaction	50.56	12.70	13	117612	53331	70757488
Fatigue	50.04	12.70	1016	116609	823303	69987516
Small cell lung cancer	49.96	12.70	40	117585	2826	70807993
Anastomotic complication	49.78	12.70	21	117604	430	70810389
Gastrointestinal perforation	49.72	12.70	54	117571	5627	70805192
Peritonitis	49.64	12.70	124	117501	26035	70784784
Sedation	49.14	12.70	9	117616	46722	70764097
Red blood cell sedimentation rate increased	49.00	12.70	4	117621	38638	70772181
Gastrooesophageal reflux disease	48.95	12.70	47	117578	90792	70720027
Cerebral infarction	48.15	12.70	169	117456	42840	70767979
Lymphopenia	48.10	12.70	126	117499	27233	70783586
Cerebral venous thrombosis	47.94	12.70	37	117588	2478	70808341
General physical health deterioration	47.89	12.70	600	117025	235431	70575388
Pericarditis	47.81	12.70	42	117583	84663	70726156
Fluid retention	47.19	12.70	23	117602	63362	70747457
Performance status decreased	46.87	12.70	52	117573	5549	70805270
Mantle cell lymphoma recurrent	46.45	12.70	21	117604	511	70810308
Neoplasm recurrence	46.45	12.70	44	117581	3897	70806922
Tremor	46.27	12.70	120	117505	155504	70655315
COVID-19	45.92	12.70	65	117560	105692	70705127
Arteriospasm coronary	45.44	12.70	53	117572	5971	70804848
Adrenocortical carcinoma	45.37	12.70	13	117612	76	70810743
Sleep disorder	45.37	12.70	30	117595	69842	70740977
Blood sodium decreased	44.86	12.70	133	117492	30865	70779954
Back pain	44.69	12.70	265	117360	270887	70539932
Hypoaesthesia	44.60	12.70	120	117505	153619	70657200
B-cell lymphoma recurrent	44.56	12.70	24	117601	860	70809959
Blood creatine phosphokinase increased	44.46	12.70	23	117602	61240	70749579
Oedema peripheral	44.21	12.70	211	117414	227880	70582939
Duodenal ulcer perforation	43.81	12.70	15	117610	51097	70759722
Aggression	43.68	12.70	13	117612	48433	70762386
Tumour perforation	43.62	12.70	18	117607	348	70810471
Pulmonary toxicity	43.35	12.70	70	117555	10728	70800091
Blood stem cell transplant failure	43.20	12.70	20	117605	515	70810304
Incorrect dose administered	42.84	12.70	29	117596	66690	70744129
Burning sensation	42.81	12.70	17	117608	52853	70757966
Drug withdrawal syndrome	42.58	12.70	3	117622	32712	70778107
Necrosis	42.03	12.70	61	117564	8520	70802299
Dermatitis acneiform	41.52	12.70	62	117563	8883	70801936
Pneumatosis intestinalis	41.44	12.70	50	117575	5837	70804982
Extremity necrosis	41.13	12.70	36	117589	2878	70807941
Cardiac disorder	40.66	12.70	24	117601	59391	70751428
Coronary artery disease	40.64	12.70	27	117598	62709	70748110
Hallucination	40.45	12.70	40	117585	76220	70734599
Intestinal ischaemia	40.22	12.70	72	117553	11992	70798827
Radiation mucositis	40.21	12.70	15	117610	219	70810600
Nervousness	40.08	12.70	3	117622	31117	70779702
Metastases to peritoneum	40.06	12.70	40	117585	3779	70807040
Palpitations	39.78	12.70	77	117548	110676	70700143
Pneumothorax	39.43	12.70	113	117512	25733	70785086
Blood pressure systolic increased	39.37	12.70	23	117602	57236	70753583
Refeeding syndrome	39.03	12.70	11	117614	60	70810759
Heart rate increased	38.82	12.70	73	117552	106075	70704744
Injection site reaction	38.80	12.70	17	117608	49835	70760984
Hypoalbuminaemia	38.79	12.70	93	117532	19029	70791790
Chronic obstructive pulmonary disease	38.63	12.70	43	117582	77598	70733221
Lactic acidosis	38.21	12.70	31	117594	64993	70745826
Testicular germ cell cancer metastatic	38.14	12.70	11	117614	66	70810753
Road traffic accident	37.97	12.70	6	117619	34676	70776143
Confusional state	37.88	12.70	296	117329	284102	70526717
Product prescribing error	37.87	12.70	9	117616	38943	70771876
Angioedema	37.62	12.70	33	117592	66577	70744242
Hydronephrosis	37.46	12.70	80	117545	15162	70795657
Product use issue	36.92	12.70	163	117462	179774	70631045
Blood lactate dehydrogenase increased	36.74	12.70	135	117490	34992	70775827
Osteosarcoma recurrent	36.71	12.70	10	117615	47	70810772
Lower respiratory tract infection	36.66	12.70	82	117543	111831	70698988
Diffuse large B-cell lymphoma	36.43	12.70	73	117552	13229	70797590
Plasmacytoma	36.29	12.70	39	117586	4015	70806804
Gastrointestinal anastomotic leak	36.18	12.70	17	117608	453	70810366
Gastrointestinal fungal infection	36.06	12.70	16	117609	372	70810447
Cerebral ischaemia	35.82	12.70	63	117562	10349	70800470
Localised infection	35.71	12.70	6	117619	33152	70777667
Unevaluable event	35.67	12.70	21	117604	52042	70758777
Hypersensitivity	35.06	12.70	230	117395	229582	70581237
Peripheral sensory neuropathy	35.03	12.70	68	117557	12042	70798777
Myasthenia gravis crisis	33.95	12.70	21	117604	980	70809839
Gait inability	33.80	12.70	18	117607	47157	70763662
Large intestinal ulcer perforation	33.74	12.70	10	117615	67	70810752
Muscular weakness	33.68	12.70	117	117508	138219	70672600
Neurosensory hypoacusis	33.59	12.70	13	117612	211	70810608
Fanconi syndrome	33.34	12.70	31	117594	2682	70808137
Ureteric rupture	32.99	12.70	7	117618	7	70810812
Coronary artery thrombosis	32.95	12.70	32	117593	2923	70807896
Blindness cortical	32.93	12.70	20	117605	903	70809916
Eye pain	32.92	12.70	8	117617	34094	70776725
Melanoderma	32.92	12.70	15	117610	372	70810447
Abortion spontaneous	32.87	12.70	3	117622	26476	70784343
Throat irritation	32.70	12.70	9	117616	35295	70775524
Toxicity to various agents	32.64	12.70	442	117183	381730	70429089
Joint stiffness	32.52	12.70	9	117616	35167	70775652
Refractory cancer	32.51	12.70	13	117612	231	70810588
Intestinal perforation	32.51	12.70	78	117547	15966	70794853
Tumour thrombosis	32.39	12.70	11	117614	120	70810699
Musculoskeletal pain	32.26	12.70	63	117562	90264	70720555
Wernicke's encephalopathy	32.18	12.70	8	117617	24	70810795
Acoustic stimulation tests abnormal	32.18	12.70	8	117617	24	70810795
Impaired healing	32.00	12.70	46	117579	74328	70736491
Cervix neoplasm	31.99	12.70	12	117613	178	70810641
Gastric disorder	31.81	12.70	8	117617	33314	70777505
Blood glucose increased	31.69	12.70	78	117547	102904	70707915
Primitive neuroectodermal tumour	31.50	12.70	9	117616	52	70810767
Mesenteric abscess	31.44	12.70	11	117614	132	70810687
Irritability	31.43	12.70	12	117613	38213	70772606
Injection site haemorrhage	31.40	12.70	3	117622	25524	70785295
Metastases to meninges	31.35	12.70	32	117593	3104	70807715
Malnutrition	31.16	12.70	89	117536	20228	70790591
Multiple sclerosis	31.03	12.70	3	117622	25282	70785537
Extravasation	30.97	12.70	33	117592	3364	70807455
Non-small cell lung cancer	30.91	12.70	45	117580	6302	70804517
Obesity	30.78	12.70	4	117621	26767	70784052
Accidental exposure to product	30.37	12.70	5	117620	28046	70782773
Nasal abscess	30.37	12.70	11	117614	147	70810672
Product administration error	30.37	12.70	6	117619	29517	70781302
Ascites	30.34	12.70	204	117421	67343	70743476
Swelling face	30.32	12.70	36	117589	63128	70747691
Seminoma	30.23	12.70	12	117613	209	70810610
Underdose	30.17	12.70	6	117619	29377	70781442
Myoclonus	30.15	12.70	4	117621	26351	70784468
Chemical peritonitis	30.13	12.70	13	117612	282	70810537
Candida infection	29.98	12.70	125	117500	34348	70776471
Visceral venous thrombosis	29.83	12.70	7	117618	15	70810804
Cholelithiasis	29.83	12.70	21	117604	47319	70763500
Labelled drug-drug interaction medication error	29.25	12.70	3	117622	24124	70786695
Limb injury	29.24	12.70	4	117621	25748	70785071
Lip swelling	29.17	12.70	10	117615	34044	70776775
Nephritis bacterial	29.13	12.70	8	117617	39	70810780
Tracheal stenosis	29.07	12.70	13	117612	308	70810511
Blood HIV RNA increased	29	12.70	23	117602	1603	70809216
EGFR gene mutation	29.00	12.70	14	117611	397	70810422
Dyskinesia	28.95	12.70	16	117609	41058	70769761
Superior mesenteric artery syndrome	28.86	12.70	11	117614	171	70810648
Hepatic steatosis	28.84	12.70	10	117615	33803	70777016
Pregnancy	28.72	12.70	3	117622	23778	70787041
Basal cell carcinoma	28.69	12.70	10	117615	33688	70777131
Femur fracture	28.63	12.70	12	117613	36120	70774699
Limb discomfort	28.61	12.70	7	117618	29698	70781121
Emotional distress	28.44	12.70	13	117612	37175	70773644
Progressive multifocal leukoencephalopathy	28.34	12.70	83	117542	19131	70791688
Oesophageal perforation	28.33	12.70	21	117604	1323	70809496
Flagellate dermatitis	28.26	12.70	12	117613	250	70810569
International normalised ratio increased	28.23	12.70	57	117568	80669	70730150
Hepatic candidiasis	28.04	12.70	9	117616	81	70810738
Lymphadenopathy mediastinal	27.90	12.70	34	117591	4011	70806808
Blood magnesium decreased	27.79	12.70	70	117555	14771	70796048
Agitation	27.74	12.70	72	117553	93303	70717516
Adenocarcinoma gastric	27.68	12.70	23	117602	1713	70809106
Hepatitis B reactivation	27.59	12.70	39	117586	5316	70805503
Neutrophil count abnormal	27.58	12.70	30	117595	3131	70807688
Sciatica	27.55	12.70	4	117621	24623	70786196
Metastases to adrenals	27.53	12.70	20	117605	1222	70809597
Cerebellar haemangioma	27.38	12.70	9	117616	88	70810731
Sleep apnoea syndrome	27.35	12.70	10	117615	32703	70778116
Haematoma	27.32	12.70	24	117601	48394	70762425
Herpes simplex encephalitis	27.12	12.70	16	117609	685	70810134
Blood pressure diastolic decreased	27.03	12.70	5	117620	25775	70785044
Therapy cessation	26.98	12.70	11	117614	33665	70777154
Prescribed overdose	26.98	12.70	6	117619	27175	70783644
Poisoning	26.94	12.70	3	117622	22619	70788200
Urinary tract infection	26.92	12.70	273	117352	248496	70562323
Upper respiratory tract infection	26.85	12.70	57	117568	79217	70731602
Blood glucose decreased	26.85	12.70	4	117621	24155	70786664
Failure to thrive	26.80	12.70	57	117568	10772	70800047
Agranulocytosis	26.77	12.70	135	117490	40163	70770656
Dry eye	26.77	12.70	10	117615	32272	70778547
Ear infection	26.67	12.70	7	117618	28329	70782490
Necrotising colitis	26.66	12.70	18	117607	977	70809842
Device issue	26.65	12.70	4	117621	24021	70786798
Metastatic gastric cancer	26.63	12.70	13	117612	378	70810441
Myocardial infarction	26.56	12.70	171	117454	171474	70639345
Testicular malignant teratoma	26.55	12.70	6	117619	10	70810809
Cholangitis	26.54	12.70	59	117566	11490	70799329
Cerebral venous sinus thrombosis	26.50	12.70	24	117601	2007	70808812
Hyperhidrosis	26.50	12.70	120	117505	131466	70679353
Papillary thyroid cancer	26.42	12.70	26	117599	2414	70808405
Right ventricular failure	26.41	12.70	3	117622	22271	70788548
Choriocarcinoma	26.26	12.70	10	117615	155	70810664
Erythropenia	26.01	12.70	13	117612	398	70810421
Plasma cell myeloma	25.98	12.70	209	117416	72992	70737827
Enterocolitis	25.92	12.70	63	117562	13003	70797816
Alpha 1 foetoprotein increased	25.82	12.70	16	117609	749	70810070
Traumatic lung injury	25.77	12.70	25	117600	2280	70808539
BK virus infection	25.77	12.70	47	117578	7942	70802877
Pancreatitis	25.75	12.70	40	117585	62628	70748191
Diabetes mellitus	25.73	12.70	50	117575	71774	70739045
Metastatic neoplasm	25.67	12.70	35	117590	4613	70806206
Pain in jaw	25.50	12.70	20	117605	42649	70768170
Haemoptysis	25.32	12.70	159	117466	51293	70759526
Swollen tongue	25.30	12.70	15	117610	37031	70773788
Prostate cancer	25.26	12.70	10	117615	31153	70779666
Aortitis	25.25	12.70	20	117605	1391	70809428
Diaphragm muscle weakness	25.20	12.70	10	117615	174	70810645
Device related infection	25.15	12.70	113	117512	32072	70778747
Gout	25.14	12.70	4	117621	23002	70787817
Prescribed underdose	25.06	12.70	3	117622	21382	70789437
Tracheo-oesophageal fistula	25.01	12.70	14	117611	542	70810277
Haemoglobin decreased	24.83	12.70	478	117147	204681	70606138
Hip fracture	24.73	12.70	8	117617	28255	70782564
Encephalopathy	24.64	12.70	181	117444	61480	70749339
Haemophagocytic lymphohistiocytosis	24.54	12.70	80	117545	19532	70791287
Wound evisceration	24.53	12.70	9	117616	125	70810694
Rib fracture	24.37	12.70	6	117619	25350	70785469
Accidental overdose	24.29	12.70	14	117611	35107	70775712
Dysstasia	24.12	12.70	6	117619	25173	70785646
Granulocyte-colony stimulating factor level increased	24.09	12.70	5	117620	4	70810815
Gene mutation	24.04	12.70	24	117601	2267	70808552
Melanosis	24.00	12.70	7	117618	44	70810775
Rhinorrhoea	23.95	12.70	46	117579	66325	70744494
Nightmare	23.88	12.70	4	117621	22152	70788667
Acne	23.85	12.70	6	117619	24983	70785836
Medulloblastoma recurrent	23.84	12.70	9	117616	136	70810683
Sopor	23.80	12.70	11	117614	31256	70779563
Ovarian vein thrombosis	23.73	12.70	7	117618	46	70810773
Oesophageal squamous cell carcinoma	23.49	12.70	13	117612	492	70810327
Liver function test abnormal	23.29	12.70	41	117584	61105	70749714
Myeloid leukaemia	23.18	12.70	14	117611	626	70810193
Hepatic cirrhosis	23.11	12.70	11	117614	30720	70780099
Asthenia	23.08	12.70	953	116672	456713	70354106
Night sweats	23.07	12.70	23	117602	43661	70767158
Chest discomfort	22.96	12.70	117	117508	124264	70686555
Lymphadenopathy	22.91	12.70	149	117476	48642	70762177
Stem cell transplant	22.90	12.70	29	117596	3556	70807263
Varicella zoster virus infection	22.72	12.70	31	117594	4089	70806730
Nephrolithiasis	22.68	12.70	27	117598	47296	70763523
Movement disorder	22.64	12.70	6	117619	24123	70786696
Crying	22.47	12.70	4	117621	21195	70789624
Retroperitoneal neoplasm metastatic	22.42	12.70	6	117619	26	70810793
Frequent bowel movements	22.40	12.70	4	117621	21149	70789670
Tooth disorder	22.37	12.70	6	117619	23932	70786887
Pharyngeal inflammation	22.34	12.70	16	117609	956	70809863
Oral candidiasis	22.11	12.70	91	117534	24861	70785958
Fanconi syndrome acquired	22.08	12.70	24	117601	2503	70808316
Staphylococcal infection	22.05	12.70	158	117467	53246	70757573
Aortic embolus	22.01	12.70	7	117618	61	70810758
Lymphangiosis carcinomatosa	21.98	12.70	21	117604	1880	70808939
Ileus	21.95	12.70	89	117536	24148	70786671
Dyspnoea	21.92	12.70	1049	116576	769011	70041808
Myelitis transverse	21.87	12.70	20	117605	1694	70809125
Retinopathy	21.83	12.70	28	117597	3478	70807341
Medication error	21.82	12.70	38	117587	56874	70753945
Fistula of small intestine	21.78	12.70	14	117611	699	70810120
Angina pectoris	21.74	12.70	29	117596	48354	70762465
Purulent pericarditis	21.71	12.70	7	117618	64	70810755
Arteritis	21.64	12.70	15	117610	850	70809969
Gingivitis ulcerative	21.54	12.70	10	117615	259	70810560
Subclavian vein thrombosis	21.54	12.70	23	117602	2351	70808468
Product quality issue	21.40	12.70	12	117613	30549	70780270
Cystitis	21.23	12.70	28	117597	46913	70763906
Transitional cell carcinoma recurrent	21.22	12.70	5	117620	11	70810808
Renal tubular dysfunction	21.19	12.70	14	117611	733	70810086
Iron deficiency anaemia	21.15	12.70	6	117619	23066	70787753
Blood culture positive	21.11	12.70	43	117582	7883	70802936
Viral load increased	21.10	12.70	24	117601	2632	70808187
Abnormal behaviour	21.08	12.70	16	117609	34693	70776126
Ischaemic stroke	21.00	12.70	104	117521	30716	70780103
Adverse event	20.87	12.70	31	117594	49430	70761389
Enterocolitis infectious	20.82	12.70	24	117601	2670	70808149
Granulocyte count decreased	20.78	12.70	18	117607	1419	70809400
Folliculitis	20.71	12.70	24	117601	42546	70768273
Amputation stump pain	20.67	12.70	6	117619	37	70810782
Iliac artery occlusion	20.54	12.70	10	117615	289	70810530
Hyperlipidaemia	20.45	12.70	7	117618	23856	70786963
Hallucination, auditory	20.45	12.70	3	117622	18325	70792494
Ovarian cancer recurrent	20.44	12.70	12	117613	509	70810310
Bone marrow disorder	20.44	12.70	25	117600	2960	70807859
Bradycardia	20.39	12.70	122	117503	124493	70686326
Mood swings	20.39	12.70	3	117622	18283	70792536
Renal tubular injury	20.39	12.70	17	117608	1272	70809547
Hypercalcaemia of malignancy	20.35	12.70	11	117614	397	70810422
Gastrointestinal necrosis	20.30	12.70	33	117592	5085	70805734
Muscle spasticity	20.26	12.70	4	117621	19685	70791134
Subcutaneous emphysema	20.24	12.70	19	117606	1663	70809156
Conductive deafness	20.24	12.70	7	117618	81	70810738
Transplant rejection	20.22	12.70	3	117622	18168	70792651
Colitis ulcerative	20.15	12.70	16	117609	33907	70776912
Immune-mediated hepatic disorder	20.13	12.70	15	117610	953	70809866
Acute promyelocytic leukaemia	20.09	12.70	18	117607	1484	70809335
Azoospermia	20.07	12.70	8	117617	141	70810678
Metastases to pleura	20.06	12.70	17	117608	1301	70809518
Non-small cell lung cancer metastatic	20.04	12.70	15	117610	959	70809860
Metastases to abdominal cavity	20.02	12.70	12	117613	529	70810290
Jaw operation	20.02	12.70	14	117611	805	70810014
Chromaturia	20.00	12.70	7	117618	23521	70787298
Apparent mineralocorticoid excess	19.89	12.70	6	117619	43	70810776
Uterine atrophy	19.87	12.70	5	117620	16	70810803
Amnesia	19.84	12.70	35	117590	52120	70758699
Immune-mediated dermatitis	19.83	12.70	10	117615	312	70810507
Hypersomnia	19.79	12.70	5	117620	20759	70790060
Extrapyramidal disorder	19.77	12.70	5	117620	20745	70790074
Pneumonia	19.76	12.70	1192	116433	595040	70215779
Osteomyelitis	19.70	12.70	13	117612	30305	70780514
Pharyngeal stenosis	19.64	12.70	5	117620	17	70810802
Multiple organ dysfunction syndrome	19.53	12.70	270	117355	108245	70702574
Abdominal pain upper	19.50	12.70	216	117409	193386	70617433
Hyperammonaemic encephalopathy	19.49	12.70	30	117595	4413	70806406
Liver abscess	19.42	12.70	34	117591	5565	70805254
Oroticaciduria	19.38	12.70	4	117621	3	70810816
Surgery	19.30	12.70	13	117612	29976	70780843
Thymoma malignant	19.21	12.70	5	117620	19	70810800
Transient ischaemic attack	19.19	12.70	29	117596	45915	70764904
Staphylococcus test positive	19.17	12.70	35	117590	5919	70804900
Alveolar soft part sarcoma	19.16	12.70	7	117618	96	70810723
Carotid artery dissection	19.10	12.70	10	117615	338	70810481
Anti-Muellerian hormone level decreased	19.10	12.70	7	117618	97	70810722
Dropped head syndrome	19.05	12.70	9	117616	243	70810576
Retinal ischaemia	19.01	12.70	13	117612	721	70810098
Heart rate irregular	19.00	12.70	13	117612	29730	70781089
Chemotherapeutic drug level increased	18.97	12.70	10	117615	343	70810476
Chemotherapy	18.96	12.70	18	117607	1598	70809221
Mucosal toxicity	18.95	12.70	12	117613	584	70810235
Hypovolaemia	18.91	12.70	64	117561	15929	70794890
Lung abscess	18.90	12.70	27	117598	3717	70807102
Oesophageal squamous cell carcinoma metastatic	18.85	12.70	4	117621	4	70810815
Trigeminal nerve paresis	18.85	12.70	4	117621	4	70810815
Maternal death affecting foetus	18.85	12.70	4	117621	4	70810815
Bone sarcoma	18.84	12.70	7	117618	101	70810718
Sinus polyp	18.81	12.70	11	117614	463	70810356
Thrombocytopenia neonatal	18.81	12.70	5	117620	21	70810798
Cervix carcinoma recurrent	18.81	12.70	5	117620	21	70810798
Ureteric dilatation	18.69	12.70	8	117617	170	70810649
Haemoperitoneum	18.58	12.70	28	117597	4043	70806776
Mental disorder	18.50	12.70	12	117613	28228	70782591
Axillary vein thrombosis	18.48	12.70	12	117613	610	70810209
Clostridium colitis	18.40	12.70	22	117603	2544	70808275
Metastases to retroperitoneum	18.30	12.70	10	117615	369	70810450
Dystonia	18.30	12.70	5	117620	19701	70791118
Testicular cancer metastatic	18.22	12.70	6	117619	59	70810760
Vertigo	18.08	12.70	49	117576	62594	70748225
Glaucoma	17.95	12.70	4	117621	18088	70792731
Embolism arterial	17.92	12.70	16	117609	1313	70809506
Sweat gland tumour	17.91	12.70	11	117614	507	70810312
Malignant pleural effusion	17.89	12.70	24	117601	3115	70807704
Gastrointestinal ischaemia	17.68	12.70	10	117615	395	70810424
Granulocytopenia	17.67	12.70	48	117577	10599	70800220
Liver function test increased	17.67	12.70	18	117607	33829	70776990
Rash pruritic	17.64	12.70	50	117575	62941	70747878
Recurrent cancer	17.62	12.70	21	117604	2420	70808399
Squamous cell carcinoma of head and neck	17.61	12.70	9	117616	289	70810530
Laryngeal pain	17.60	12.70	33	117592	5695	70805124
Eczema	17.59	12.70	18	117607	33763	70777056
Campylobacter test positive	17.54	12.70	6	117619	67	70810752
Delusion	17.54	12.70	5	117620	19160	70791659
Eye irritation	17.51	12.70	4	117621	17784	70793035
Pericardial effusion	17.48	12.70	124	117501	41652	70769167
Procedural vomiting	17.39	12.70	12	117613	675	70810144
Adenoviral hepatitis	17.36	12.70	13	117612	832	70809987
Hot flush	17.34	12.70	35	117590	49549	70761270
Clostridium bacteraemia	17.31	12.70	9	117616	300	70810519
Synovial sarcoma	17.30	12.70	6	117619	70	70810749
Acute myelomonocytic leukaemia	17.28	12.70	9	117616	301	70810518
Sinus disorder	17.25	12.70	5	117620	18954	70791865
Extragonadal primary germ cell tumour mixed	17.23	12.70	4	117621	8	70810811
Cardiac pseudoaneurysm	17.23	12.70	6	117619	71	70810748
Morphoea	17.21	12.70	10	117615	416	70810403
Median nerve injury	17.20	12.70	5	117620	31	70810788
Neck pain	17.16	12.70	55	117570	66602	70744217
Small intestinal perforation	17.14	12.70	23	117602	2986	70807833
Joint range of motion decreased	17.13	12.70	11	117614	26015	70784804
Embryonal rhabdomyosarcoma	17.08	12.70	6	117619	73	70810746
Depressed mood	17.04	12.70	29	117596	43791	70767028
Embolism venous	16.92	12.70	26	117599	3819	70807000
Sinus congestion	16.92	12.70	4	117621	17369	70793450
Jugular vein occlusion	16.92	12.70	4	117621	9	70810810
Carotid artery thrombosis	16.91	12.70	21	117604	2525	70808294
Sarcomatoid carcinoma	16.80	12.70	5	117620	34	70810785
Neoplasm malignant	16.79	12.70	93	117532	28681	70782138
Metastases to abdominal wall	16.70	12.70	7	117618	141	70810678
Clonal haematopoiesis	16.68	12.70	5	117620	35	70810784
Portal vein thrombosis	16.61	12.70	31	117594	5331	70805488
Ganglioneuroma	16.56	12.70	7	117618	144	70810675
Restless legs syndrome	16.51	12.70	5	117620	18423	70792396
Vascular injury	16.48	12.70	14	117611	1075	70809744
Staphylococcal bacteraemia	16.46	12.70	48	117577	11034	70799785
Intentional product use issue	16.46	12.70	124	117501	120018	70690801
Venous thrombosis	16.46	12.70	35	117590	6614	70804205
Herpes zoster	16.41	12.70	79	117546	85156	70725663
Lung cancer metastatic	16.38	12.70	24	117601	3381	70807438
Organising pneumonia	16.37	12.70	45	117580	10005	70800814
Thrombophlebitis migrans	16.35	12.70	9	117616	337	70810482
Pneumonia adenoviral	16.26	12.70	10	117615	462	70810357
Sepsis pasteurella	16.21	12.70	3	117622	0	70810819
Emphysematous cholecystitis	16.21	12.70	3	117622	0	70810819
Oesophageal squamous cell carcinoma recurrent	16.21	12.70	3	117622	0	70810819
Kidney infection	16.17	12.70	6	117619	19449	70791370
Dysphonia	16.16	12.70	37	117588	50063	70760756
Disturbance in attention	16.12	12.70	29	117596	42865	70767954
Metapneumovirus bronchiolitis	16.09	12.70	4	117621	12	70810807
Paraneoplastic syndrome	16.07	12.70	13	117612	932	70809887
Leukaemic lymphoma	16.06	12.70	6	117619	88	70810731
Alopecia	16.05	12.70	232	117393	198258	70612561
Cannabinoid hyperemesis syndrome	15.99	12.70	5	117620	41	70810778
Non-small cell lung cancer stage IIIB	15.88	12.70	5	117620	42	70810777
Marchiafava-Bignami disease	15.85	12.70	4	117621	13	70810806
Bone erosion	15.78	12.70	3	117622	15170	70795649
Retinal toxicity	15.72	12.70	15	117610	1341	70809478
Depressed level of consciousness	15.71	12.70	83	117542	87348	70723471
Respiratory arrest	15.70	12.70	42	117583	53891	70756928
Skin toxicity	15.68	12.70	36	117589	7162	70803657
Device malfunction	15.67	12.70	6	117619	19078	70791741
Myositis	15.66	12.70	64	117561	17425	70793394
Gastroenteritis viral	15.65	12.70	8	117617	21447	70789372
Thrombophlebitis	15.65	12.70	32	117593	5884	70804935
Therapy interrupted	15.63	12.70	11	117614	24791	70786028
Skin exfoliation	15.62	12.70	36	117589	48590	70762229
Proctitis	15.57	12.70	24	117601	3534	70807285
Toxic leukoencephalopathy	15.43	12.70	13	117612	987	70809832
Eosinophilia	15.39	12.70	27	117598	40292	70770527
Necrosis ischaemic	15.38	12.70	13	117612	991	70809828
Cell-mediated immune deficiency	15.36	12.70	6	117619	100	70810719
Dementia	15.35	12.70	9	117616	22356	70788463
Metastases to thorax	15.35	12.70	7	117618	174	70810645
Meningitis tuberculous	15.33	12.70	14	117611	1183	70809636
Hernia	15.33	12.70	3	117622	14857	70795962
Body temperature decreased	15.25	12.70	15	117610	28657	70782162
Hypertension	15.24	12.70	374	117251	295659	70515160
Noctiphobia	15.20	12.70	4	117621	16	70810803
Gastrointestinal haemorrhage	15.18	12.70	150	117475	137258	70673561
Upper limb fracture	15.14	12.70	4	117621	16115	70794704
Hepatoblastoma	15.11	12.70	5	117620	50	70810769
Hypoxia	15.11	12.70	228	117397	93116	70717703
Fistula	15.09	12.70	46	117579	10835	70799984
Cellulitis	15.07	12.70	99	117526	98829	70711990
Muscle twitching	15.05	12.70	7	117618	19820	70790999
Death	15.03	12.70	692	116933	509369	70301450
Spinal stenosis	15.03	12.70	3	117622	14650	70796169
Metastases to the mediastinum	14.96	12.70	10	117615	534	70810285
Platelet transfusion	14.93	12.70	18	117607	2100	70808719
Immune-mediated myocarditis	14.79	12.70	11	117614	697	70810122
Neoplasm	14.75	12.70	37	117588	7787	70803032
Cerebral salt-wasting syndrome	14.73	12.70	6	117619	112	70810707
Blood loss anaemia	14.72	12.70	3	117622	14438	70796381
Pulmonary artery thrombosis	14.69	12.70	14	117611	1249	70809570
Paraneoplastic dermatomyositis	14.69	12.70	5	117620	55	70810764
Cervix cancer metastatic	14.65	12.70	4	117621	19	70810800
Myasthenic syndrome	14.65	12.70	11	117614	707	70810112
Nasopharyngeal cancer	14.61	12.70	7	117618	195	70810624
Enterobacter infection	14.53	12.70	25	117600	4035	70806784
Haematochezia	14.50	12.70	67	117558	73014	70737805
Oral fungal infection	14.46	12.70	22	117603	3204	70807615
Evans syndrome	14.46	12.70	9	117616	425	70810394
Metastases to pelvis	14.44	12.70	10	117615	566	70810253
Cytokine release syndrome	14.42	12.70	84	117541	26383	70784436
Adrenal insufficiency	14.41	12.70	81	117544	25114	70785705
Ovarian failure	14.41	12.70	10	117615	568	70810251
Pelvic fluid collection	14.41	12.70	11	117614	725	70810094
Hypoglossal nerve paresis	14.40	12.70	6	117619	119	70810700
Procedural nausea	14.34	12.70	11	117614	730	70810089
Intestinal infarction	14.33	12.70	14	117611	1288	70809531
Diabetes mellitus inadequate control	14.33	12.70	10	117615	22635	70788184
Conjunctivitis	14.31	12.70	10	117615	22626	70788193
Pneumonia salmonella	14.29	12.70	5	117620	60	70810759
Enterococcal bacteraemia	14.26	12.70	20	117605	2706	70808113
Anaplastic lymphoma kinase gene mutation	14.26	12.70	6	117619	122	70810697
Procedural pain	14.24	12.70	6	117619	18003	70792816
Poor quality sleep	14.23	12.70	8	117617	20341	70790478
Renal-limited thrombotic microangiopathy	14.16	12.70	4	117621	22	70810797
Carotid artery perforation	14.14	12.70	3	117622	3	70810816
Epithelioid mesothelioma	14.14	12.70	3	117622	3	70810816
Non-renal cell carcinoma of kidney	14.14	12.70	3	117622	3	70810816
Endothelial dysfunction	14.11	12.70	7	117618	211	70810608
Vascular pseudoaneurysm	14.08	12.70	22	117603	3279	70807540
BRAF gene mutation	14.07	12.70	5	117620	63	70810756
Thymus enlargement	14.04	12.70	6	117619	127	70810692
Laryngeal cancer stage IV	14.01	12.70	4	117621	23	70810796
B-cell lymphoma refractory	14.00	12.70	6	117619	128	70810691
Unresponsive to stimuli	13.97	12.70	42	117583	51889	70758930
Stent malfunction	13.93	12.70	5	117620	65	70810754
Vaginitis gardnerella	13.87	12.70	4	117621	24	70810795
Nephropathy	13.86	12.70	39	117586	8786	70802033
Thrombocytosis	13.83	12.70	36	117589	7748	70803071
Mood altered	13.83	12.70	5	117620	16470	70794349
Dyspnoea exertional	13.79	12.70	75	117550	78355	70732464
Culture urine positive	13.76	12.70	25	117600	4212	70806607
Adenocarcinoma	13.74	12.70	23	117602	3630	70807189
Enterococcal sepsis	13.74	12.70	19	117606	2538	70808281
Fracture	13.72	12.70	8	117617	19936	70790883
Oesophageal prosthesis insertion	13.68	12.70	3	117622	4	70810815
Abdominal pain	13.66	12.70	696	116929	341431	70469388
Skin ulcer	13.64	12.70	38	117587	48107	70762712
Neuroblastoma	13.61	12.70	8	117617	340	70810479
Rhabdoid tumour	13.60	12.70	4	117621	26	70810793
VIth nerve paresis	13.58	12.70	6	117619	138	70810681
Thrombotic thrombocytopenic purpura	13.57	12.70	31	117594	6146	70804673
Retroperitoneal neoplasm	13.47	12.70	4	117621	27	70810792
Glycosylated haemoglobin increased	13.42	12.70	6	117619	17385	70793434
Fear	13.42	12.70	9	117616	20802	70790017
Mydriasis	13.40	12.70	5	117620	16148	70794671
Tachycardia	13.37	12.70	351	117274	158195	70652624
Streptococcus test positive	13.37	12.70	17	117608	2094	70808725
Adenocarcinoma of appendix	13.34	12.70	5	117620	74	70810745
Head and neck cancer	13.33	12.70	7	117618	238	70810581
Oxygen saturation decreased	13.32	12.70	126	117499	116303	70694516
Capillary leak syndrome	13.30	12.70	22	117603	3440	70807379
Paranoia	13.29	12.70	6	117619	17282	70793537
Epiphyses premature fusion	13.28	12.70	5	117620	75	70810744
Hyperglycaemic hyperosmolar nonketotic syndrome	13.25	12.70	16	117609	1870	70808949
Gastroenteritis sapovirus	13.23	12.70	6	117619	147	70810672
Immune-mediated lung disease	13.21	12.70	15	117610	1642	70809177
Metastases to bladder	13.17	12.70	7	117618	244	70810575
Hypothermia	13.15	12.70	9	117616	20585	70790234
Hemianopia	13.15	12.70	15	117610	1650	70809169
Mania	13.14	12.70	6	117619	17168	70793651
Retroperitoneal lymphadenopathy	13.10	12.70	12	117613	1018	70809801
Systemic infection	13.10	12.70	32	117593	6625	70804194
Eye pruritus	13.08	12.70	4	117621	14643	70796176
White blood cell disorder	13.07	12.70	20	117605	2928	70807891
Diabetic ketoacidosis	13.05	12.70	20	117605	31492	70779327
Blood iron decreased	13.02	12.70	3	117622	13258	70797561
Carpal tunnel syndrome	12.99	12.70	6	117619	17051	70793768
Hepatic function abnormal	12.98	12.70	171	117454	67825	70742994
Coma	12.96	12.70	94	117531	91750	70719069
Peritoneal sarcoma	12.93	12.70	3	117622	6	70810813
Stoma site dermatitis	12.93	12.70	3	117622	6	70810813
Visual impairment	12.90	12.70	79	117546	80171	70730648
Feeling cold	12.89	12.70	14	117611	25556	70785263
Metastatic squamous cell carcinoma	12.88	12.70	9	117616	517	70810302
Germ cell cancer	12.84	12.70	6	117619	158	70810661
Blood phosphorus decreased	12.83	12.70	30	117595	6039	70804780
Delirium	12.76	12.70	72	117553	74542	70736277
Cough	12.72	12.70	427	117198	324950	70485869

FDA Adverse Event Reporting System (Pediatric)

None

Pharmacologic Action:

Source	Code	Description
ATC	L01XA01	ANTINEOPLASTIC AND IMMUNOMODULATING AGENTS ANTINEOPLASTIC AGENTS OTHER ANTINEOPLASTIC AGENTS Platinum compounds
FDA EXT	N0000175073	Platinum-containing Compounds
FDA EPC	N0000175413	Platinum-based Drug
MeSH PA	D000970	Antineoplastic Agents
MeSH PA	D003432	Cross-Linking Reagents
MeSH PA	D007202	Indicators and Reagents
MeSH PA	D011838	Radiation-Sensitizing Agents
CHEBI has role	CHEBI:25435	mutagens
CHEBI has role	CHEBI:35610	antineoplastic agents
CHEBI has role	CHEBI:47868	photosensitising agent
CHEBI has role	CHEBI:50684	cross-linking reagents
CHEBI has role	CHEBI:50902	genotoxic agent
CHEBI has role	CHEBI:61015	nephrotoxins
CHEBI has role	CHEBI:68495	Type I cell-death inducers
CHEBI has role	CHEBI:173085	ferroptosis inducers

Drug Use | Suggest Off label Use Form| |View source of the data|

Disease	Relation	SNOMED_ID	DOID
Malignant tumor of ovary	indication	363443007	DOID:2394
Ovarian Germ Cell Tumor Carcinoma	indication
Testicular Germ Cell Tumor	indication
Invasive Bladder Malignancy	indication

🐶 Veterinary Drug Use

None

🐶 Veterinary products

None

Acid dissociation constants calculated using MoKa v3.0.0

None

Orange Book patent data (new drug applications)

None

Orange Book exclusivity data (new drug applications)

None

Bioactivity Summary:

Target	Class	Pharos	UniProt	Action	Type	Activity value (-log[M])	Mechanism action	Bioact source	MoA source
D(3) dopamine receptor	GPCR	P35462	DRD3_HUMAN		Ki	5.95		CHEMBL
Muscarinic acetylcholine receptor M5	GPCR	P08912	ACM5_HUMAN		Ki	5.37		CHEMBL
Canalicular multispecific organic anion transporter 1	Transporter	Q92887	MRP2_HUMAN					WOMBAT-PK
Adenosine receptor A3	GPCR	P0DMS8	AA3R_HUMAN		Ki	5.62		DRUG MATRIX
Multidrug resistance-associated protein 6	Transporter	O95255	MRP6_HUMAN					WOMBAT-PK
Multidrug resistance-associated protein 5	Transporter	O15440	MRP5_HUMAN					WOMBAT-PK
Epidermal growth factor receptor	Kinase	P00533	EGFR_HUMAN		IC50	5.58		DRUG MATRIX
Tyrosine-protein kinase Lck	Kinase	P06239	LCK_HUMAN		IC50	4.64		DRUG MATRIX
Tyrosine-protein kinase Fyn	Kinase	P06241	FYN_HUMAN		IC50	5.32		DRUG MATRIX
C-X-C chemokine receptor type 2	GPCR	P25025	CXCR2_HUMAN		Ki	5.02		DRUG MATRIX
Thromboxane-A synthase	Enzyme	P24557	THAS_HUMAN		IC50	5.03		DRUG MATRIX
C-C chemokine receptor type 2	GPCR	P41597	CCR2_HUMAN		Ki	5.15		DRUG MATRIX
Mitogen-activated protein kinase 3	Kinase	P27361	MK03_HUMAN		IC50	5.34		DRUG MATRIX
Melanocortin receptor 5	GPCR	P33032	MC5R_HUMAN		Ki	5.22		DRUG MATRIX
Sodium/potassium-transporting ATPase subunit alpha-2	Ion channel		AT1A2_PIG		IC50	5.03		DRUG MATRIX

External reference:

ID	Source
D00275	KEGG_DRUG
4018139	VUID
N0000146476	NUI
4018139	VANDF
C0008838	UMLSCUI
CHEBI:27899	CHEBI
CPT	PDB_CHEM_ID
CHEMBL1386	ChEMBL_ID
CHEMBL11359	ChEMBL_ID
CHEMBL2068237	ChEMBL_ID
DB00515	DRUGBANK_ID
5343	IUPHAR_LIGAND_ID
4426	INN_ID
Q20Q21Q62J	UNII
5702198	PUBCHEM_CID
2555	RXNORM
31747	MMSL
4456	MMSL
d00195	MMSL
002641	NDDF
387318005	SNOMEDCT_US
57066004	SNOMEDCT_US
D002945	MESH_DESCRIPTOR_UI

Pharmaceutical products:

Product	Category	Ingredients	NDC	Form	Quantity	Route	Marketing	Label
CISplatin	HUMAN PRESCRIPTION DRUG LABEL	1	0143-9504	INJECTION	1 mg	INTRAVENOUS	ANDA	19 sections
CISplatin	HUMAN PRESCRIPTION DRUG LABEL	1	0143-9505	INJECTION	1 mg	INTRAVENOUS	ANDA	19 sections
Cisplatin	HUMAN PRESCRIPTION DRUG LABEL	1	0703-5747	INJECTION, SOLUTION	50 mg	INTRAVENOUS	ANDA	29 sections
Cisplatin	HUMAN PRESCRIPTION DRUG LABEL	1	0703-5747	INJECTION, SOLUTION	50 mg	INTRAVENOUS	ANDA	29 sections
Cisplatin	HUMAN PRESCRIPTION DRUG LABEL	1	0703-5748	INJECTION, SOLUTION	100 mg	INTRAVENOUS	ANDA	29 sections
Cisplatin	HUMAN PRESCRIPTION DRUG LABEL	1	0703-5748	INJECTION, SOLUTION	100 mg	INTRAVENOUS	ANDA	29 sections
Cisplatin	HUMAN PRESCRIPTION DRUG LABEL	1	16729-288	INJECTION	1 mg	INTRAVENOUS	ANDA	26 sections
CISplatin	HUMAN PRESCRIPTION DRUG LABEL	1	44567-509	INJECTION, SOLUTION	1 mg	INTRAVENOUS	NDA	19 sections
CISplatin	HUMAN PRESCRIPTION DRUG LABEL	1	44567-510	INJECTION, SOLUTION	1 mg	INTRAVENOUS	NDA	19 sections
CISplatin	HUMAN PRESCRIPTION DRUG LABEL	1	44567-511	INJECTION, SOLUTION	1 mg	INTRAVENOUS	NDA	19 sections
Cisplatin	HUMAN PRESCRIPTION DRUG LABEL	1	44567-530	INJECTION, POWDER, LYOPHILIZED, FOR SOLUTION	1 mg	INTRAVENOUS	NDA	26 sections
Cisplatin	HUMAN PRESCRIPTION DRUG LABEL	1	63323-103	INJECTION, SOLUTION	1 mg	INTRAVENOUS	ANDA	13 sections
Cisplatin	HUMAN PRESCRIPTION DRUG LABEL	1	68001-283	INJECTION	1 mg	INTRAVENOUS	ANDA	26 sections
CISPLATIN	Human Prescription Drug Label	1	68083-162	INJECTION, SOLUTION	1 mg	INTRAVENOUS	ANDA	13 sections
CISPLATIN	Human Prescription Drug Label	1	68083-163	INJECTION, SOLUTION	1 mg	INTRAVENOUS	ANDA	13 sections
Cisplatin	HUMAN PRESCRIPTION DRUG LABEL	1	70860-206	INJECTION, SOLUTION	1 mg	INTRAVENOUS	ANDA	21 sections