Stem definition | Drug id | CAS RN |
---|---|---|
antineoplastic agents, platinum derivatives | 4392 | 15663-27-1 |
Molecule | Description |
---|---|
Synonyms:
|
An inorganic and water-soluble platinum complex. After undergoing hydrolysis, it reacts with DNA to produce both intra and interstrand crosslinks. These crosslinks appear to impair replication and transcription of DNA. The cytotoxicity of cisplatin correlates with cellular arrest in the G2 phase of the cell cycle.
|
None
Property | Value | Reference |
---|---|---|
BDDCS (Biopharmaceutical Drug Disposition Classification System) | 1 | Benet LZ, Broccatelli F, Oprea TI |
S (Water solubility) | 2.53 mg/mL | Benet LZ, Broccatelli F, Oprea TI |
EoM (Fraction excreted unchanged in urine) | 2.30 % | Benet LZ, Broccatelli F, Oprea TI |
MRTD (Maximum Recommended Therapeutic Daily Dose) | 4.75 ยตM/kg/day | Contrera JF, Matthews EJ, Kruhlak NL, Benz RD |
Date | Agency | Company | Orphan |
---|---|---|---|
Dec. 19, 1978 | FDA | HQ SPCLT PHARMA |
MedDRA adverse event term | Likelihood ratio | Likelihood ratio threshold | Patients taking drug having adverse event | Patients taking drug not having adverse event | Patients not taking drug having adverse event | Patients not taking drug not having adverse event |
---|---|---|---|---|---|---|
Febrile neutropenia | 1070.56 | 15.52 | 853 | 51678 | 96814 | 50455779 |
Neutropenia | 975.81 | 15.52 | 969 | 51562 | 146996 | 50405597 |
Thrombocytopenia | 677.41 | 15.52 | 745 | 51786 | 126928 | 50425665 |
Malignant neoplasm progression | 536.74 | 15.52 | 493 | 52038 | 67631 | 50484962 |
Bone marrow failure | 476.59 | 15.52 | 318 | 52213 | 27306 | 50525287 |
Disease progression | 471.26 | 15.52 | 538 | 51993 | 95328 | 50457265 |
Haematotoxicity | 466.77 | 15.52 | 206 | 52325 | 7689 | 50544904 |
Mucosal inflammation | 458.92 | 15.52 | 360 | 52171 | 39782 | 50512811 |
Vomiting | 414.58 | 15.52 | 1229 | 51302 | 459529 | 50093064 |
Ototoxicity | 404.75 | 15.52 | 113 | 52418 | 1014 | 50551579 |
Anaemia | 368.99 | 15.52 | 810 | 51721 | 251646 | 50300947 |
Pancytopenia | 328.41 | 15.52 | 420 | 52111 | 83610 | 50468983 |
Myelosuppression | 291.04 | 15.52 | 179 | 52352 | 13338 | 50539255 |
Acute myeloid leukaemia | 268.27 | 15.52 | 177 | 52354 | 14897 | 50537696 |
Nausea | 266.83 | 15.52 | 1434 | 51097 | 703964 | 49848629 |
Dehydration | 259.32 | 15.52 | 521 | 52010 | 151928 | 50400665 |
Leukopenia | 255.09 | 15.52 | 332 | 52199 | 67196 | 50485397 |
Posterior reversible encephalopathy syndrome | 248.13 | 15.52 | 168 | 52363 | 14760 | 50537833 |
Arthralgia | 239.37 | 15.52 | 79 | 52452 | 438623 | 50113970 |
Second primary malignancy | 233.78 | 15.52 | 123 | 52408 | 6791 | 50545802 |
Hypomagnesaemia | 218.87 | 15.52 | 186 | 52345 | 22970 | 50529623 |
Off label use | 214.15 | 15.52 | 1015 | 51516 | 473411 | 50079182 |
Joint swelling | 194.89 | 15.52 | 16 | 52515 | 245270 | 50307323 |
Renal salt-wasting syndrome | 185.36 | 15.52 | 45 | 52486 | 216 | 50552377 |
Hypokalaemia | 179.36 | 15.52 | 325 | 52206 | 87667 | 50464926 |
Neutrophil count decreased | 173.28 | 15.52 | 226 | 52305 | 45800 | 50506793 |
Deafness | 171.17 | 15.52 | 137 | 52394 | 15554 | 50537039 |
Myelodysplastic syndrome | 166.95 | 15.52 | 133 | 52398 | 14999 | 50537594 |
Diffuse large B-cell lymphoma recurrent | 153.51 | 15.52 | 59 | 52472 | 1536 | 50551057 |
Gastrointestinal toxicity | 151.88 | 15.52 | 81 | 52450 | 4596 | 50547997 |
Pain | 150.40 | 15.52 | 231 | 52300 | 578672 | 49973921 |
Aortic thrombosis | 149.23 | 15.52 | 51 | 52480 | 938 | 50551655 |
Neutropenic sepsis | 142.68 | 15.52 | 118 | 52413 | 14029 | 50538564 |
Fall | 138.04 | 15.52 | 89 | 52442 | 334843 | 50217750 |
Product dose omission issue | 137.98 | 15.52 | 15 | 52516 | 183823 | 50368770 |
Metastases to lung | 134.88 | 15.52 | 103 | 52428 | 10917 | 50541676 |
Abdominal discomfort | 134.60 | 15.52 | 37 | 52494 | 231604 | 50320989 |
Platelet count decreased | 134.06 | 15.52 | 312 | 52219 | 100414 | 50452179 |
Peripheral swelling | 131.24 | 15.52 | 27 | 52504 | 205909 | 50346684 |
Metastases to central nervous system | 130.56 | 15.52 | 102 | 52429 | 11180 | 50541413 |
Drug resistance | 129.42 | 15.52 | 127 | 52404 | 18862 | 50533731 |
Arthropathy | 129.03 | 15.52 | 9 | 52522 | 157897 | 50394696 |
Teratoma | 125.36 | 15.52 | 29 | 52502 | 108 | 50552485 |
Neoplasm progression | 123.71 | 15.52 | 152 | 52379 | 29005 | 50523588 |
Nephropathy toxic | 120.78 | 15.52 | 85 | 52446 | 7944 | 50544649 |
Ovarian germ cell teratoma | 118.40 | 15.52 | 25 | 52506 | 53 | 50552540 |
Drug ineffective | 115.60 | 15.52 | 450 | 52081 | 818883 | 49733710 |
Contraindicated product administered | 114.75 | 15.52 | 11 | 52520 | 148947 | 50403646 |
Pyrexia | 114.07 | 15.52 | 729 | 51802 | 379474 | 50173119 |
Weight increased | 114.03 | 15.52 | 34 | 52497 | 201857 | 50350736 |
Sepsis | 113.26 | 15.52 | 349 | 52182 | 132576 | 50420017 |
Musculoskeletal stiffness | 112.11 | 15.52 | 5 | 52526 | 128476 | 50424117 |
Acute kidney injury | 110.48 | 15.52 | 499 | 52032 | 227559 | 50325034 |
Therapeutic product effect decreased | 110.43 | 15.52 | 8 | 52523 | 136042 | 50416551 |
Urogenital fistula | 109.57 | 15.52 | 26 | 52505 | 111 | 50552482 |
Pulmonary embolism | 106.91 | 15.52 | 288 | 52243 | 101416 | 50451177 |
Hyponatraemia | 105.88 | 15.52 | 277 | 52254 | 95862 | 50456731 |
Drug hypersensitivity | 104.29 | 15.52 | 66 | 52465 | 250944 | 50301649 |
Product use in unapproved indication | 104.20 | 15.52 | 310 | 52221 | 115509 | 50437084 |
Swelling | 102.74 | 15.52 | 40 | 52491 | 200832 | 50351761 |
Diffuse large B-cell lymphoma refractory | 101.77 | 15.52 | 39 | 52492 | 1007 | 50551586 |
Cardiotoxicity | 100.18 | 15.52 | 72 | 52459 | 6955 | 50545638 |
Oesophagitis | 99.68 | 15.52 | 94 | 52437 | 13289 | 50539304 |
Neurotoxicity | 95.66 | 15.52 | 96 | 52435 | 14644 | 50537949 |
Pain in extremity | 91.58 | 15.52 | 89 | 52442 | 272776 | 50279817 |
Nasopharyngitis | 91.35 | 15.52 | 43 | 52488 | 192884 | 50359709 |
Headache | 90.67 | 15.52 | 250 | 52281 | 506285 | 50046308 |
Hydronephrosis | 87.70 | 15.52 | 72 | 52459 | 8469 | 50544124 |
Cardiomyopathy | 87.64 | 15.52 | 94 | 52437 | 15492 | 50537101 |
Septic shock | 85.97 | 15.52 | 186 | 52345 | 56989 | 50495604 |
Rash | 85.87 | 15.52 | 206 | 52325 | 437265 | 50115328 |
Pruritus | 85.68 | 15.52 | 101 | 52430 | 283467 | 50269126 |
Tumour lysis syndrome | 85.66 | 15.52 | 67 | 52464 | 7354 | 50545239 |
Hypocalcaemia | 84.72 | 15.52 | 121 | 52410 | 26695 | 50525898 |
White blood cell count decreased | 80.19 | 15.52 | 285 | 52246 | 116437 | 50436156 |
Hypophagia | 80.19 | 15.52 | 120 | 52411 | 27608 | 50524985 |
Renal failure | 79.91 | 15.52 | 268 | 52263 | 106365 | 50446228 |
Disease recurrence | 79.28 | 15.52 | 101 | 52430 | 19980 | 50532613 |
Metastases to lymph nodes | 78.03 | 15.52 | 62 | 52469 | 6962 | 50545631 |
Arthritis | 76.89 | 15.52 | 3 | 52528 | 86718 | 50465875 |
Condition aggravated | 76.40 | 15.52 | 119 | 52412 | 296939 | 50255654 |
Neuropathy peripheral | 75.00 | 15.52 | 246 | 52285 | 96511 | 50456082 |
Injection site pain | 73.98 | 15.52 | 13 | 52518 | 111011 | 50441582 |
Insomnia | 73.94 | 15.52 | 45 | 52486 | 174820 | 50377773 |
Metastases to liver | 71.43 | 15.52 | 96 | 52435 | 20008 | 50532585 |
Wound | 71.34 | 15.52 | 12 | 52519 | 105782 | 50446811 |
Renal tubular disorder | 70.23 | 15.52 | 39 | 52492 | 2398 | 50550195 |
Teratoma benign | 69.72 | 15.52 | 16 | 52515 | 57 | 50552536 |
Sinusitis | 69.22 | 15.52 | 46 | 52485 | 170512 | 50382081 |
Contusion | 68.79 | 15.52 | 16 | 52515 | 112167 | 50440426 |
Febrile bone marrow aplasia | 68.60 | 15.52 | 55 | 52476 | 6256 | 50546337 |
Tinnitus | 67.82 | 15.52 | 112 | 52419 | 28020 | 50524573 |
Ascites | 64.93 | 15.52 | 126 | 52405 | 35735 | 50516858 |
Therapy partial responder | 64.42 | 15.52 | 54 | 52477 | 6537 | 50546056 |
Asthma | 62.81 | 15.52 | 9 | 52522 | 89328 | 50463265 |
Metastases to skin | 62.63 | 15.52 | 30 | 52501 | 1353 | 50551240 |
Electrolyte imbalance | 62.55 | 15.52 | 83 | 52448 | 17086 | 50535507 |
Migraine | 62.31 | 15.52 | 4 | 52527 | 75276 | 50477317 |
Leukoencephalopathy | 60.48 | 15.52 | 42 | 52489 | 3841 | 50548752 |
Renal tubular necrosis | 60.13 | 15.52 | 63 | 52468 | 10105 | 50542488 |
Abdominal pain | 59.90 | 15.52 | 435 | 52096 | 235793 | 50316800 |
Palmar-plantar erythrodysaesthesia syndrome | 59.57 | 15.52 | 88 | 52443 | 20010 | 50532583 |
Gastrointestinal perforation | 59.49 | 15.52 | 38 | 52493 | 3023 | 50549570 |
Muscle spasms | 59.37 | 15.52 | 28 | 52503 | 125525 | 50427068 |
Radiation skin injury | 59.12 | 15.52 | 25 | 52506 | 838 | 50551755 |
Drug intolerance | 58.98 | 15.52 | 85 | 52446 | 219019 | 50333574 |
Hepatic enzyme increased | 57.16 | 15.52 | 36 | 52495 | 137344 | 50415249 |
Diarrhoea | 56.94 | 15.52 | 891 | 51640 | 587585 | 49965008 |
Pleural effusion | 56.87 | 15.52 | 200 | 52331 | 81254 | 50471339 |
Deafness bilateral | 56.76 | 15.52 | 27 | 52504 | 1199 | 50551394 |
Metastases to breast | 56.37 | 15.52 | 18 | 52513 | 265 | 50552328 |
Decreased appetite | 56.21 | 15.52 | 379 | 52152 | 200544 | 50352049 |
Oesophageal fistula | 55.80 | 15.52 | 15 | 52516 | 115 | 50552478 |
Blister | 54.77 | 15.52 | 11 | 52520 | 85407 | 50467186 |
Pericarditis | 52.88 | 15.52 | 9 | 52522 | 78680 | 50473913 |
Ovarian cancer recurrent | 52.07 | 15.52 | 23 | 52508 | 859 | 50551734 |
Polyneuropathy | 51.05 | 15.52 | 63 | 52468 | 12068 | 50540525 |
Large intestine perforation | 50.83 | 15.52 | 50 | 52481 | 7444 | 50545149 |
Myasthenia gravis crisis | 50.80 | 15.52 | 18 | 52513 | 370 | 50552223 |
Metastases to bone | 50.77 | 15.52 | 77 | 52454 | 17918 | 50534675 |
Blood creatinine increased | 48.92 | 15.52 | 182 | 52349 | 75978 | 50476615 |
Urticaria | 48.55 | 15.52 | 38 | 52493 | 129523 | 50423070 |
Osteoarthritis | 48.02 | 15.52 | 7 | 52524 | 68599 | 50483994 |
Overdose | 47.51 | 15.52 | 22 | 52509 | 99705 | 50452888 |
Injection site erythema | 47.32 | 15.52 | 10 | 52521 | 74926 | 50477667 |
Loss of personal independence in daily activities | 47.10 | 15.52 | 8 | 52523 | 70042 | 50482551 |
Gait disturbance | 46.78 | 15.52 | 52 | 52479 | 149953 | 50402640 |
Renal impairment | 46.27 | 15.52 | 178 | 52353 | 75483 | 50477110 |
Peripheral artery thrombosis | 46 | 15.52 | 26 | 52505 | 1654 | 50550939 |
Suicidal ideation | 45.66 | 15.52 | 3 | 52528 | 55382 | 50497211 |
Feeling abnormal | 45.53 | 15.52 | 38 | 52493 | 125454 | 50427139 |
Infusion related reaction | 45.39 | 15.52 | 66 | 52465 | 169491 | 50383102 |
Deep vein thrombosis | 44.45 | 15.52 | 172 | 52359 | 73132 | 50479461 |
Depression | 43.68 | 15.52 | 65 | 52466 | 165358 | 50387235 |
Fatigue | 43.14 | 15.52 | 499 | 52032 | 707102 | 49845491 |
Haemoglobin decreased | 43.04 | 15.52 | 252 | 52279 | 126964 | 50425629 |
Metastases to peritoneum | 42.62 | 15.52 | 30 | 52501 | 2803 | 50549790 |
Mobility decreased | 42.37 | 15.52 | 15 | 52516 | 79933 | 50472660 |
Bronchitis | 42.35 | 15.52 | 28 | 52503 | 104131 | 50448462 |
Encephalopathy | 42.16 | 15.52 | 102 | 52429 | 33609 | 50518984 |
Discomfort | 41.61 | 15.52 | 31 | 52500 | 108349 | 50444244 |
Mesenteric abscess | 41.19 | 15.52 | 11 | 52520 | 82 | 50552511 |
Inappropriate antidiuretic hormone secretion | 41.06 | 15.52 | 59 | 52472 | 13084 | 50539509 |
Alopecia | 40.72 | 15.52 | 125 | 52406 | 244922 | 50307671 |
Chemical peritonitis | 40.29 | 15.52 | 11 | 52520 | 90 | 50552503 |
Somnolence | 39.86 | 15.52 | 62 | 52469 | 154923 | 50397670 |
Cystitis haemorrhagic | 39.68 | 15.52 | 32 | 52499 | 3670 | 50548923 |
Anastomotic leak | 38.65 | 15.52 | 15 | 52516 | 401 | 50552192 |
Large intestinal ulcer perforation | 38.37 | 15.52 | 10 | 52521 | 67 | 50552526 |
Ileus | 37.88 | 15.52 | 57 | 52474 | 13172 | 50539421 |
Recall phenomenon | 37.74 | 15.52 | 16 | 52515 | 540 | 50552053 |
Bicytopenia | 37.54 | 15.52 | 24 | 52507 | 1912 | 50550681 |
Hospitalisation | 37.30 | 15.52 | 12 | 52519 | 67925 | 50484668 |
Malignant transformation | 37.26 | 15.52 | 14 | 52517 | 342 | 50552251 |
Performance status decreased | 37.21 | 15.52 | 29 | 52502 | 3166 | 50549427 |
Wernicke's encephalopathy | 36.97 | 15.52 | 8 | 52523 | 20 | 50552573 |
Ureteric rupture | 36.26 | 15.52 | 7 | 52524 | 7 | 50552586 |
Nasal abscess | 36.21 | 15.52 | 11 | 52520 | 136 | 50552457 |
Metastases to abdominal wall | 36.19 | 15.52 | 10 | 52521 | 86 | 50552507 |
Cervix neoplasm | 36.10 | 15.52 | 12 | 52519 | 202 | 50552391 |
Dermatitis | 36.06 | 15.52 | 58 | 52473 | 14193 | 50538400 |
Gastric perforation | 35.59 | 15.52 | 21 | 52510 | 1449 | 50551144 |
Fibromyalgia | 35.47 | 15.52 | 3 | 52528 | 44975 | 50507618 |
Embryonal rhabdomyosarcoma | 35.32 | 15.52 | 7 | 52524 | 9 | 50552584 |
Dizziness | 35.24 | 15.52 | 213 | 52318 | 346156 | 50206437 |
Nephritis bacterial | 35.19 | 15.52 | 8 | 52523 | 27 | 50552566 |
Cataract | 35.09 | 15.52 | 4 | 52527 | 47296 | 50505297 |
Neutropenic colitis | 34.99 | 15.52 | 25 | 52506 | 2392 | 50550201 |
Melanoderma | 34.83 | 15.52 | 11 | 52520 | 156 | 50552437 |
Radiation injury | 34.75 | 15.52 | 14 | 52517 | 414 | 50552179 |
Balance disorder | 34.52 | 15.52 | 15 | 52516 | 70575 | 50482018 |
Unevaluable event | 33.91 | 15.52 | 4 | 52527 | 46062 | 50506531 |
Asthenia | 33.77 | 15.52 | 491 | 52040 | 318551 | 50234042 |
Exposure during pregnancy | 33.47 | 15.52 | 46 | 52485 | 120969 | 50431624 |
Gastrointestinal fungal infection | 33.45 | 15.52 | 12 | 52519 | 256 | 50552337 |
Haemophagocytic lymphohistiocytosis | 33.41 | 15.52 | 43 | 52488 | 8590 | 50544003 |
Cerebral venous thrombosis | 33.35 | 15.52 | 22 | 52509 | 1849 | 50550744 |
Injection site reaction | 33.01 | 15.52 | 6 | 52525 | 50026 | 50502567 |
Malnutrition | 32.44 | 15.52 | 53 | 52478 | 13136 | 50539457 |
Bladder perforation | 32.32 | 15.52 | 10 | 52521 | 132 | 50552461 |
Chloroma | 32.30 | 15.52 | 11 | 52520 | 200 | 50552393 |
Intentional product misuse | 32.17 | 15.52 | 5 | 52526 | 46729 | 50505864 |
Varicella zoster virus infection | 32.08 | 15.52 | 24 | 52507 | 2465 | 50550128 |
Cardiac tamponade | 32.03 | 15.52 | 30 | 52501 | 4202 | 50548391 |
Injury | 31.99 | 15.52 | 6 | 52525 | 48919 | 50503674 |
Nasal congestion | 31.91 | 15.52 | 7 | 52524 | 51113 | 50501480 |
Adverse drug reaction | 31.68 | 15.52 | 9 | 52522 | 55213 | 50497380 |
Metastases to adrenals | 31.26 | 15.52 | 15 | 52516 | 679 | 50551914 |
Axillary vein thrombosis | 30.67 | 15.52 | 12 | 52519 | 328 | 50552265 |
Maternal exposure during pregnancy | 30.63 | 15.52 | 76 | 52455 | 159702 | 50392891 |
Enteritis | 30.52 | 15.52 | 37 | 52494 | 6958 | 50545635 |
Pericardial effusion | 30.48 | 15.52 | 76 | 52455 | 25513 | 50527080 |
Stress | 30.43 | 15.52 | 9 | 52522 | 53784 | 50498809 |
Memory impairment | 30.07 | 15.52 | 23 | 52508 | 79337 | 50473256 |
Vesical fistula | 29.91 | 15.52 | 8 | 52523 | 60 | 50552533 |
Abortion spontaneous | 29.84 | 15.52 | 4 | 52527 | 41768 | 50510825 |
Lower respiratory tract infection | 29.67 | 15.52 | 33 | 52498 | 95168 | 50457425 |
Hypophosphataemia | 29.61 | 15.52 | 40 | 52491 | 8374 | 50544219 |
White blood cell count abnormal | 29.16 | 15.52 | 32 | 52499 | 5408 | 50547185 |
Haemolytic uraemic syndrome | 29.09 | 15.52 | 22 | 52509 | 2297 | 50550296 |
Peripheral sensory neuropathy | 28.98 | 15.52 | 35 | 52496 | 6556 | 50546037 |
Wrong technique in product usage process | 28.43 | 15.52 | 11 | 52520 | 55499 | 50497094 |
Herpes simplex encephalitis | 28.10 | 15.52 | 11 | 52520 | 301 | 50552292 |
Venoocclusive liver disease | 28.10 | 15.52 | 28 | 52503 | 4233 | 50548360 |
Sinus polyp | 27.90 | 15.52 | 11 | 52520 | 307 | 50552286 |
Enterocolitis infectious | 27.86 | 15.52 | 18 | 52513 | 1460 | 50551133 |
Vena cava thrombosis | 27.20 | 15.52 | 20 | 52511 | 2001 | 50550592 |
Acoustic stimulation tests abnormal | 27.18 | 15.52 | 8 | 52523 | 88 | 50552505 |
Disseminated intravascular coagulation | 27.18 | 15.52 | 57 | 52474 | 17078 | 50535515 |
Anxiety | 27.12 | 15.52 | 94 | 52437 | 177512 | 50375081 |
Radiation pneumonitis | 27.01 | 15.52 | 17 | 52514 | 1318 | 50551275 |
Thymus enlargement | 26.86 | 15.52 | 8 | 52523 | 92 | 50552501 |
Tumour haemorrhage | 26.77 | 15.52 | 17 | 52514 | 1338 | 50551255 |
Treatment failure | 26.74 | 15.52 | 65 | 52466 | 137572 | 50415021 |
Alveolar soft part sarcoma | 26.33 | 15.52 | 8 | 52523 | 99 | 50552494 |
Peripheral ischaemia | 26.19 | 15.52 | 27 | 52504 | 4249 | 50548344 |
Respiratory symptom | 26.15 | 15.52 | 21 | 52510 | 2393 | 50550200 |
Acquired gene mutation | 25.88 | 15.52 | 14 | 52517 | 817 | 50551776 |
Female genital tract fistula | 25.87 | 15.52 | 25 | 52506 | 3641 | 50548952 |
Intestinal perforation | 25.63 | 15.52 | 42 | 52489 | 10437 | 50542156 |
Clostridium bacteraemia | 25.54 | 15.52 | 9 | 52522 | 182 | 50552411 |
Gastrooesophageal reflux disease | 25.49 | 15.52 | 25 | 52506 | 76403 | 50476190 |
Cytopenia | 25.39 | 15.52 | 38 | 52493 | 8737 | 50543856 |
Adverse event | 25.35 | 15.52 | 7 | 52524 | 43756 | 50508837 |
Fistula of small intestine | 25.27 | 15.52 | 10 | 52521 | 282 | 50552311 |
Metastases to meninges | 25.13 | 15.52 | 19 | 52512 | 1983 | 50550610 |
Blood cholesterol increased | 25.05 | 15.52 | 13 | 52518 | 55202 | 50497391 |
Aortic embolus | 25.03 | 15.52 | 6 | 52525 | 27 | 50552566 |
Metastases to abdominal cavity | 25.02 | 15.52 | 11 | 52520 | 406 | 50552187 |
Respiratory failure | 24.85 | 15.52 | 171 | 52360 | 91010 | 50461583 |
Wheezing | 24.79 | 15.52 | 17 | 52514 | 62030 | 50490563 |
Hypoalbuminaemia | 24.77 | 15.52 | 40 | 52491 | 9820 | 50542773 |
Chronic kidney disease | 24.66 | 15.52 | 94 | 52437 | 39677 | 50512916 |
Dysphagia | 24.56 | 15.52 | 151 | 52380 | 77367 | 50475226 |
Inappropriate schedule of product administration | 24.54 | 15.52 | 23 | 52508 | 71808 | 50480785 |
Osteoporosis | 24.51 | 15.52 | 8 | 52523 | 44871 | 50507722 |
Neoplasm recurrence | 24.38 | 15.52 | 20 | 52511 | 2349 | 50550244 |
Amputation stump pain | 24.35 | 15.52 | 6 | 52525 | 31 | 50552562 |
Impaired healing | 24.25 | 15.52 | 22 | 52509 | 69764 | 50482829 |
Cerebellar haemangioma | 24.21 | 15.52 | 7 | 52524 | 72 | 50552521 |
Drug clearance decreased | 24.17 | 15.52 | 15 | 52516 | 1134 | 50551459 |
Influenza like illness | 23.96 | 15.52 | 15 | 52516 | 57444 | 50495149 |
Metastasis | 23.91 | 15.52 | 26 | 52505 | 4349 | 50548244 |
Jaw operation | 23.90 | 15.52 | 13 | 52518 | 767 | 50551826 |
Suicide attempt | 23.74 | 15.52 | 12 | 52519 | 51720 | 50500873 |
Neutrophil count abnormal | 23.73 | 15.52 | 20 | 52511 | 2439 | 50550154 |
Arteriospasm coronary | 23.63 | 15.52 | 23 | 52508 | 3379 | 50549214 |
Chronic obstructive pulmonary disease | 23.62 | 15.52 | 13 | 52518 | 53422 | 50499171 |
Stem cell transplant | 23.57 | 15.52 | 17 | 52514 | 1651 | 50550942 |
Multiple organ dysfunction syndrome | 23.43 | 15.52 | 109 | 52422 | 50228 | 50502365 |
Oesophageal stenosis | 23.07 | 15.52 | 21 | 52510 | 2837 | 50549756 |
Malignant peritoneal neoplasm | 23.03 | 15.52 | 12 | 52519 | 649 | 50551944 |
Malaise | 22.99 | 15.52 | 230 | 52301 | 335302 | 50217291 |
Bacteraemia | 22.88 | 15.52 | 48 | 52483 | 14385 | 50538208 |
Embolism | 22.83 | 15.52 | 32 | 52499 | 6936 | 50545657 |
Enterococcal sepsis | 22.74 | 15.52 | 15 | 52516 | 1260 | 50551333 |
Radiation oesophagitis | 22.44 | 15.52 | 9 | 52522 | 263 | 50552330 |
Ovarian vein thrombosis | 22.44 | 15.52 | 6 | 52525 | 45 | 50552548 |
Acute myelomonocytic leukaemia | 22.33 | 15.52 | 8 | 52523 | 170 | 50552423 |
Anti-Muellerian hormone level decreased | 22.31 | 15.52 | 7 | 52524 | 97 | 50552496 |
Influenza | 21.90 | 15.52 | 37 | 52494 | 89501 | 50463092 |
Femur fracture | 21.69 | 15.52 | 6 | 52525 | 37458 | 50515135 |
Burning sensation | 21.68 | 15.52 | 10 | 52521 | 45436 | 50507157 |
Fluid retention | 21.43 | 15.52 | 13 | 52518 | 50636 | 50501957 |
Folliculitis | 21.40 | 15.52 | 7 | 52524 | 39218 | 50513375 |
Proctitis | 21.37 | 15.52 | 17 | 52514 | 1911 | 50550682 |
Oroticaciduria | 21.25 | 15.52 | 4 | 52527 | 3 | 50552590 |
Blood magnesium decreased | 21.16 | 15.52 | 40 | 52491 | 11120 | 50541473 |
Osteosarcoma metastatic | 21.14 | 15.52 | 5 | 52526 | 21 | 50552572 |
Vascular compression | 21.10 | 15.52 | 7 | 52524 | 117 | 50552476 |
Incorrect dose administered | 21.08 | 15.52 | 12 | 52519 | 48402 | 50504191 |
Neck pain | 21.03 | 15.52 | 17 | 52514 | 57050 | 50495543 |
Median nerve injury | 20.95 | 15.52 | 5 | 52526 | 22 | 50552571 |
Blood glucose increased | 20.85 | 15.52 | 26 | 52505 | 71298 | 50481295 |
Osteosarcoma | 20.83 | 15.52 | 7 | 52524 | 122 | 50552471 |
Muscular weakness | 20.80 | 15.52 | 42 | 52489 | 94971 | 50457622 |
Cervix carcinoma recurrent | 20.77 | 15.52 | 5 | 52526 | 23 | 50552570 |
Hiccups | 20.72 | 15.52 | 16 | 52515 | 1723 | 50550870 |
Maternal death affecting foetus | 20.72 | 15.52 | 4 | 52527 | 4 | 50552589 |
Vision blurred | 20.65 | 15.52 | 31 | 52500 | 78616 | 50473977 |
Failure to thrive | 20.53 | 15.52 | 29 | 52502 | 6329 | 50546264 |
Therapy responder | 20.50 | 15.52 | 9 | 52522 | 331 | 50552262 |
Ill-defined disorder | 20.50 | 15.52 | 16 | 52515 | 54638 | 50497955 |
Pulmonary toxicity | 20.43 | 15.52 | 27 | 52504 | 5535 | 50547058 |
Medulloblastoma recurrent | 20.39 | 15.52 | 6 | 52525 | 66 | 50552527 |
Lymphopenia | 20.32 | 15.52 | 48 | 52483 | 15573 | 50537020 |
Myalgia | 20.21 | 15.52 | 64 | 52467 | 124255 | 50428338 |
Diabetes mellitus | 20.17 | 15.52 | 13 | 52518 | 49020 | 50503573 |
Pulmonary vascular disorder | 20.13 | 15.52 | 9 | 52522 | 346 | 50552247 |
Odynophagia | 19.93 | 15.52 | 29 | 52502 | 6503 | 50546090 |
Tachycardia | 19.90 | 15.52 | 174 | 52357 | 99589 | 50453004 |
Radiation proctitis | 19.83 | 15.52 | 4 | 52527 | 6 | 50552587 |
Product quality issue | 19.72 | 15.52 | 4 | 52527 | 30854 | 50521739 |
Superior sagittal sinus thrombosis | 19.52 | 15.52 | 11 | 52520 | 696 | 50551897 |
Renal-limited thrombotic microangiopathy | 19.45 | 15.52 | 4 | 52527 | 7 | 50552586 |
VIth nerve paresis | 19.41 | 15.52 | 6 | 52525 | 79 | 50552514 |
Refeeding syndrome | 19.38 | 15.52 | 5 | 52526 | 32 | 50552561 |
Blood sodium decreased | 19.35 | 15.52 | 57 | 52474 | 21090 | 50531503 |
Radiation mucositis | 19.25 | 15.52 | 5 | 52526 | 33 | 50552560 |
Leukaemic lymphoma | 19.07 | 15.52 | 6 | 52525 | 84 | 50552509 |
Pain in jaw | 19.05 | 15.52 | 8 | 52523 | 38420 | 50514173 |
Hypoaesthesia | 18.98 | 15.52 | 68 | 52463 | 127189 | 50425404 |
Drug clearance increased | 18.94 | 15.52 | 6 | 52525 | 86 | 50552507 |
Gastrointestinal necrosis | 18.87 | 15.52 | 18 | 52513 | 2580 | 50550013 |
Salivary gland cancer | 18.86 | 15.52 | 7 | 52524 | 165 | 50552428 |
Low cardiac output syndrome | 18.84 | 15.52 | 8 | 52523 | 271 | 50552322 |
Stomatitis | 18.80 | 15.52 | 174 | 52357 | 101170 | 50451423 |
Marchiafava-Bignami disease | 18.78 | 15.52 | 4 | 52527 | 9 | 50552584 |
Purulent pericarditis | 18.76 | 15.52 | 5 | 52526 | 37 | 50552556 |
Cardiac failure congestive | 18.73 | 15.52 | 37 | 52494 | 84345 | 50468248 |
Pregnancy | 18.56 | 15.52 | 4 | 52527 | 29573 | 50523020 |
Gastric disorder | 18.53 | 15.52 | 4 | 52527 | 29544 | 50523049 |
Blood pressure fluctuation | 18.51 | 15.52 | 7 | 52524 | 35816 | 50516777 |
Hypoglycaemia | 18.48 | 15.52 | 17 | 52514 | 53564 | 50499029 |
Pelvic fluid collection | 18.47 | 15.52 | 11 | 52520 | 772 | 50551821 |
Adrenocortical carcinoma | 18.41 | 15.52 | 5 | 52526 | 40 | 50552553 |
Cerebral salt-wasting syndrome | 18.30 | 15.52 | 5 | 52526 | 41 | 50552552 |
Hypoacusis | 18.28 | 15.52 | 55 | 52476 | 20592 | 50532001 |
Gastroenteritis radiation | 18.25 | 15.52 | 9 | 52522 | 433 | 50552160 |
Central obesity | 18.17 | 15.52 | 12 | 52519 | 1010 | 50551583 |
Sinus tachycardia | 18.08 | 15.52 | 56 | 52475 | 21298 | 50531295 |
Respiratory distress | 18.03 | 15.52 | 71 | 52460 | 30418 | 50522175 |
Sweat gland tumour | 17.99 | 15.52 | 6 | 52525 | 102 | 50552491 |
Tumour invasion | 17.94 | 15.52 | 6 | 52525 | 103 | 50552490 |
Mucosal erosion | 17.92 | 15.52 | 13 | 52518 | 1274 | 50551319 |
Hypoglossal nerve paresis | 17.78 | 15.52 | 6 | 52525 | 106 | 50552487 |
Myasthenic syndrome | 17.77 | 15.52 | 7 | 52524 | 195 | 50552398 |
Emphysematous cholecystitis | 17.61 | 15.52 | 3 | 52528 | 0 | 50552593 |
Urinary tract toxicity | 17.61 | 15.52 | 3 | 52528 | 0 | 50552593 |
Hypersensitivity | 17.56 | 15.52 | 141 | 52390 | 215020 | 50337573 |
Acute respiratory distress syndrome | 17.55 | 15.52 | 55 | 52476 | 21044 | 50531549 |
Transdifferentiation of neoplasm | 17.48 | 15.52 | 4 | 52527 | 14 | 50552579 |
Tumour thrombosis | 17.48 | 15.52 | 4 | 52527 | 14 | 50552579 |
Necrosis | 17.41 | 15.52 | 23 | 52508 | 4713 | 50547880 |
Product use issue | 17.30 | 15.52 | 88 | 52443 | 149387 | 50403206 |
Osteoradionecrosis | 17.28 | 15.52 | 6 | 52525 | 116 | 50552477 |
Aorto-oesophageal fistula | 17.27 | 15.52 | 4 | 52527 | 15 | 50552578 |
Ovarian failure | 17.26 | 15.52 | 12 | 52519 | 1099 | 50551494 |
Ovarian disorder | 17.19 | 15.52 | 10 | 52521 | 672 | 50551921 |
Hepatic lesion | 17.16 | 15.52 | 21 | 52510 | 3987 | 50548606 |
Urogenital disorder | 17.16 | 15.52 | 5 | 52526 | 53 | 50552540 |
Roseolovirus test positive | 17.16 | 15.52 | 5 | 52526 | 53 | 50552540 |
Dry eye | 17.04 | 15.52 | 6 | 52525 | 32089 | 50520504 |
Fanconi syndrome | 17.02 | 15.52 | 12 | 52519 | 1124 | 50551469 |
Cytomegalovirus infection | 17.00 | 15.52 | 49 | 52482 | 17913 | 50534680 |
Neurosensory hypoacusis | 16.98 | 15.52 | 7 | 52524 | 220 | 50552373 |
Necrotising colitis | 16.95 | 15.52 | 9 | 52522 | 506 | 50552087 |
Metastases to pelvis | 16.78 | 15.52 | 8 | 52523 | 357 | 50552236 |
Cardiopulmonary failure | 16.64 | 15.52 | 19 | 52512 | 3354 | 50549239 |
Sleep disorder | 16.62 | 15.52 | 21 | 52510 | 57262 | 50495331 |
Melanosis | 16.51 | 15.52 | 4 | 52527 | 19 | 50552574 |
Abdominal compartment syndrome | 16.45 | 15.52 | 9 | 52522 | 537 | 50552056 |
Lip swelling | 16.24 | 15.52 | 3 | 52528 | 24733 | 50527860 |
Blood pressure increased | 16.20 | 15.52 | 77 | 52454 | 133055 | 50419538 |
Agitation | 16.09 | 15.52 | 19 | 52512 | 53365 | 50499228 |
Stent malfunction | 16.02 | 15.52 | 5 | 52526 | 68 | 50552525 |
Blood culture positive | 15.96 | 15.52 | 21 | 52510 | 4287 | 50548306 |
Limb discomfort | 15.89 | 15.52 | 3 | 52528 | 24354 | 50528239 |
Road traffic accident | 15.89 | 15.52 | 3 | 52528 | 24349 | 50528244 |
Plasma cell leukaemia | 15.86 | 15.52 | 11 | 52520 | 1004 | 50551589 |
Hypoxia | 15.82 | 15.52 | 99 | 52432 | 51024 | 50501569 |
Eye pain | 15.66 | 15.52 | 5 | 52526 | 28444 | 50524149 |
Granulocytopenia | 15.63 | 15.52 | 23 | 52508 | 5208 | 50547385 |
VIth nerve disorder | 15.54 | 15.52 | 3 | 52528 | 3 | 50552590 |
Metastases to pleura | 15.52 | 15.52 | 12 | 52519 | 1294 | 50551299 |
MedDRA adverse event term | Likelihood ratio | Likelihood ratio threshold | Patients taking drug having adverse event | Patients taking drug not having adverse event | Patients not taking drug having adverse event | Patients not taking drug not having adverse event |
---|---|---|---|---|---|---|
Febrile neutropenia | 1391.34 | 13.00 | 1567 | 74025 | 110673 | 29388262 |
Neutropenia | 890.94 | 13.00 | 1366 | 74226 | 130345 | 29368590 |
Mucosal inflammation | 759.36 | 13.00 | 636 | 74956 | 30959 | 29467976 |
Thrombocytopenia | 534.54 | 13.00 | 1108 | 74484 | 133715 | 29365220 |
Malignant neoplasm progression | 418.44 | 13.00 | 708 | 74884 | 73151 | 29425784 |
Pancytopenia | 365.32 | 13.00 | 714 | 74878 | 82454 | 29416481 |
Dehydration | 362.75 | 13.00 | 862 | 74730 | 113886 | 29385049 |
Bone marrow failure | 342.98 | 13.00 | 386 | 75206 | 27063 | 29471872 |
Leukopenia | 332.30 | 13.00 | 544 | 75048 | 54659 | 29444276 |
Disease progression | 325.96 | 13.00 | 675 | 74917 | 81241 | 29417694 |
Vomiting | 305.27 | 13.00 | 1209 | 74383 | 211051 | 29287884 |
Stomatitis | 275.44 | 13.00 | 403 | 75189 | 36710 | 29462225 |
Myelosuppression | 260.59 | 13.00 | 230 | 75362 | 11997 | 29486938 |
Neutropenic sepsis | 258.77 | 13.00 | 225 | 75367 | 11502 | 29487433 |
Haematotoxicity | 258.41 | 13.00 | 179 | 75413 | 6520 | 29492415 |
Nausea | 249.88 | 13.00 | 1421 | 74171 | 287834 | 29211101 |
Acute myeloid leukaemia | 240.78 | 13.00 | 252 | 75340 | 16261 | 29482674 |
Dysphagia | 231.78 | 13.00 | 464 | 75128 | 54462 | 29444473 |
Neoplasm progression | 217.65 | 13.00 | 253 | 75339 | 18359 | 29480576 |
Second primary malignancy | 205.80 | 13.00 | 156 | 75436 | 6549 | 29492386 |
Anaemia | 204.92 | 13.00 | 1034 | 74558 | 199917 | 29299018 |
Neutrophil count decreased | 201.97 | 13.00 | 383 | 75209 | 43184 | 29455751 |
Product dose omission issue | 189.73 | 13.00 | 15 | 75577 | 96368 | 29402567 |
Drug abuse | 188.79 | 13.00 | 3 | 75589 | 79880 | 29419055 |
Pulmonary embolism | 182.74 | 13.00 | 518 | 75074 | 76016 | 29422919 |
Off label use | 171.53 | 13.00 | 1333 | 74259 | 299467 | 29199468 |
Aortic thrombosis | 168.46 | 13.00 | 64 | 75528 | 617 | 29498318 |
Fall | 166.38 | 13.00 | 126 | 75466 | 177052 | 29321883 |
Arthralgia | 165.40 | 13.00 | 75 | 75517 | 139542 | 29359393 |
Nephropathy toxic | 161.91 | 13.00 | 167 | 75425 | 10589 | 29488346 |
Renal salt-wasting syndrome | 157.62 | 13.00 | 44 | 75548 | 134 | 29498801 |
Myelodysplastic syndrome | 143.33 | 13.00 | 201 | 75391 | 17593 | 29481342 |
Pyrexia | 139.86 | 13.00 | 1230 | 74362 | 286392 | 29212543 |
Drug interaction | 129.62 | 13.00 | 190 | 75402 | 197195 | 29301740 |
Therapy partial responder | 127.46 | 13.00 | 106 | 75486 | 5093 | 29493842 |
Decreased appetite | 122.15 | 13.00 | 710 | 74882 | 144632 | 29354303 |
Hyponatraemia | 116.46 | 13.00 | 409 | 75183 | 67224 | 29431711 |
Cardiotoxicity | 114.80 | 13.00 | 96 | 75496 | 4648 | 29494287 |
Headache | 111.77 | 13.00 | 170 | 75422 | 173837 | 29325098 |
Septic shock | 110.03 | 13.00 | 381 | 75211 | 62179 | 29436756 |
Ototoxicity | 109.22 | 13.00 | 61 | 75531 | 1504 | 29497431 |
Hypomagnesaemia | 108.81 | 13.00 | 175 | 75417 | 17293 | 29481642 |
Overdose | 107.51 | 13.00 | 35 | 75557 | 79784 | 29419151 |
Anastomotic leak | 105.52 | 13.00 | 44 | 75548 | 552 | 29498383 |
Diffuse large B-cell lymphoma refractory | 105.11 | 13.00 | 50 | 75542 | 872 | 29498063 |
Tumour lysis syndrome | 104.69 | 13.00 | 152 | 75440 | 13732 | 29485203 |
Oesophagitis | 102.50 | 13.00 | 139 | 75453 | 11784 | 29487151 |
White blood cell count decreased | 101.38 | 13.00 | 452 | 75140 | 82910 | 29416025 |
Acute kidney injury | 96.76 | 13.00 | 1069 | 74523 | 264198 | 29234737 |
Cardiac failure congestive | 95.62 | 13.00 | 38 | 75554 | 76543 | 29422392 |
Arterial thrombosis | 95.16 | 13.00 | 54 | 75538 | 1374 | 29497561 |
Weight increased | 92.56 | 13.00 | 40 | 75552 | 76627 | 29422308 |
Rhabdomyolysis | 92.51 | 13.00 | 21 | 75571 | 60787 | 29438148 |
Radiation skin injury | 90.34 | 13.00 | 41 | 75551 | 639 | 29498296 |
Aorto-oesophageal fistula | 90.12 | 13.00 | 22 | 75570 | 31 | 29498904 |
Hypophagia | 89.93 | 13.00 | 178 | 75414 | 20694 | 29478241 |
Tinnitus | 88.59 | 13.00 | 150 | 75442 | 15464 | 29483471 |
Febrile bone marrow aplasia | 87.70 | 13.00 | 101 | 75491 | 7250 | 29491685 |
Depression | 85.79 | 13.00 | 56 | 75536 | 85091 | 29413844 |
Odynophagia | 84.16 | 13.00 | 80 | 75512 | 4590 | 29494345 |
Peripheral swelling | 83.98 | 13.00 | 29 | 75563 | 63710 | 29435225 |
Gastric perforation | 83.32 | 13.00 | 58 | 75534 | 2128 | 29496807 |
Muscle spasms | 81.72 | 13.00 | 32 | 75560 | 65050 | 29433885 |
Inappropriate antidiuretic hormone secretion | 81.43 | 13.00 | 119 | 75473 | 10813 | 29488122 |
Deafness | 80.09 | 13.00 | 113 | 75479 | 9942 | 29488993 |
Sepsis | 79.56 | 13.00 | 630 | 74962 | 142052 | 29356883 |
Vena cava thrombosis | 77.43 | 13.00 | 42 | 75550 | 976 | 29497959 |
Peripheral ischaemia | 76.16 | 13.00 | 79 | 75513 | 5040 | 29493895 |
Hospitalisation | 75.99 | 13.00 | 13 | 75579 | 45975 | 29452960 |
Joint swelling | 75.77 | 13.00 | 17 | 75575 | 49613 | 29449322 |
Anxiety | 73.43 | 13.00 | 66 | 75526 | 85299 | 29413636 |
Peripheral artery thrombosis | 73.25 | 13.00 | 53 | 75539 | 2069 | 29496866 |
Platelet count decreased | 73.17 | 13.00 | 488 | 75104 | 104184 | 29394751 |
Metastases to lung | 72.77 | 13.00 | 95 | 75497 | 7760 | 29491175 |
Product use in unapproved indication | 72.58 | 13.00 | 424 | 75168 | 86451 | 29412484 |
Intentional product misuse | 72.25 | 13.00 | 4 | 75588 | 34657 | 29464278 |
Metastases to central nervous system | 71.98 | 13.00 | 90 | 75502 | 7041 | 29491894 |
Osteoradionecrosis | 71.62 | 13.00 | 20 | 75572 | 61 | 29498874 |
Suicide attempt | 70.90 | 13.00 | 4 | 75588 | 34106 | 29464829 |
Suicidal ideation | 69.40 | 13.00 | 5 | 75587 | 34711 | 29464224 |
Nasopharyngitis | 69.09 | 13.00 | 33 | 75559 | 59632 | 29439303 |
Insomnia | 69.01 | 13.00 | 75 | 75517 | 88686 | 29410249 |
Myalgia | 68.87 | 13.00 | 53 | 75539 | 73966 | 29424969 |
Musculoskeletal stiffness | 67.94 | 13.00 | 8 | 75584 | 37450 | 29461485 |
Neutropenic colitis | 67.22 | 13.00 | 53 | 75539 | 2358 | 29496577 |
Bacterial translocation | 67.09 | 13.00 | 24 | 75568 | 192 | 29498743 |
Aplasia | 66.46 | 13.00 | 66 | 75526 | 3997 | 29494938 |
Pain in extremity | 66.01 | 13.00 | 113 | 75479 | 110320 | 29388615 |
Hypokalaemia | 65.39 | 13.00 | 278 | 75314 | 49925 | 29449010 |
Death | 65.06 | 13.00 | 561 | 75031 | 341523 | 29157412 |
Blood pressure increased | 64.75 | 13.00 | 56 | 75536 | 73747 | 29425188 |
Splenic infarction | 63.64 | 13.00 | 46 | 75546 | 1793 | 29497142 |
General physical health deterioration | 62.77 | 13.00 | 464 | 75128 | 102393 | 29396542 |
Dermatitis | 62.65 | 13.00 | 88 | 75504 | 7710 | 29491225 |
Gastrointestinal toxicity | 61.92 | 13.00 | 48 | 75544 | 2083 | 29496852 |
Oesophageal fistula | 61.60 | 13.00 | 22 | 75570 | 175 | 29498760 |
Psoriasis | 60.69 | 13.00 | 6 | 75586 | 32221 | 29466714 |
Rheumatoid arthritis | 57.98 | 13.00 | 7 | 75585 | 32145 | 29466790 |
Renal failure | 57.70 | 13.00 | 508 | 75084 | 118091 | 29380844 |
Atypical haemolytic uraemic syndrome | 57.49 | 13.00 | 20 | 75572 | 146 | 29498789 |
Portal venous gas | 56.24 | 13.00 | 24 | 75568 | 320 | 29498615 |
Radiation pneumonitis | 55.79 | 13.00 | 46 | 75546 | 2183 | 29496752 |
Pneumonitis | 55.66 | 13.00 | 178 | 75414 | 27866 | 29471069 |
Inappropriate schedule of product administration | 55.60 | 13.00 | 22 | 75570 | 44450 | 29454485 |
Asthma | 54.98 | 13.00 | 10 | 75582 | 33839 | 29465096 |
Cardiac disorder | 54.44 | 13.00 | 14 | 75578 | 37249 | 29461686 |
Condition aggravated | 54.17 | 13.00 | 192 | 75400 | 146103 | 29352832 |
Thrombotic microangiopathy | 54.09 | 13.00 | 87 | 75505 | 8594 | 29490341 |
Injection site pain | 53.98 | 13.00 | 9 | 75583 | 32437 | 29466498 |
Acute respiratory distress syndrome | 53.42 | 13.00 | 154 | 75438 | 22781 | 29476154 |
Hypocalcaemia | 53.30 | 13.00 | 144 | 75448 | 20521 | 29478414 |
Tremor | 52.99 | 13.00 | 66 | 75526 | 73472 | 29425463 |
Hiccups | 52.82 | 13.00 | 87 | 75505 | 8766 | 29490169 |
Aggression | 52.61 | 13.00 | 13 | 75579 | 35528 | 29463407 |
Electrolyte imbalance | 52.03 | 13.00 | 99 | 75493 | 11175 | 29487760 |
Dizziness | 51.94 | 13.00 | 279 | 75313 | 189405 | 29309530 |
Hepatitis B | 51.73 | 13.00 | 67 | 75525 | 5430 | 29493505 |
Diffuse large B-cell lymphoma recurrent | 51.64 | 13.00 | 47 | 75545 | 2550 | 29496385 |
Malignant transformation | 51.47 | 13.00 | 30 | 75562 | 804 | 29498131 |
Oesophagobronchial fistula | 50.75 | 13.00 | 18 | 75574 | 140 | 29498795 |
Neuropathy peripheral | 50.71 | 13.00 | 333 | 75259 | 70694 | 29428241 |
Tumour necrosis | 50.09 | 13.00 | 33 | 75559 | 1104 | 29497831 |
Pulmonary vascular disorder | 50.09 | 13.00 | 26 | 75566 | 551 | 29498384 |
Deafness neurosensory | 49.99 | 13.00 | 46 | 75546 | 2532 | 29496403 |
Gait disturbance | 49.60 | 13.00 | 69 | 75523 | 73280 | 29425655 |
Wheezing | 49.51 | 13.00 | 12 | 75580 | 33228 | 29465707 |
Radiation oesophagitis | 49.31 | 13.00 | 23 | 75569 | 383 | 29498552 |
Metastases to liver | 48.54 | 13.00 | 99 | 75493 | 11757 | 29487178 |
Vision blurred | 48.40 | 13.00 | 21 | 75571 | 40155 | 29458780 |
Hallucination | 48.38 | 13.00 | 27 | 75565 | 44685 | 29454250 |
Drug ineffective | 47.88 | 13.00 | 648 | 74944 | 362522 | 29136413 |
Blood creatine phosphokinase increased | 47.78 | 13.00 | 22 | 75570 | 40622 | 29458313 |
Bacteraemia | 47.49 | 13.00 | 119 | 75473 | 16204 | 29482731 |
Ameloblastoma | 47.25 | 13.00 | 15 | 75577 | 79 | 29498856 |
Deep vein thrombosis | 47.15 | 13.00 | 279 | 75313 | 57120 | 29441815 |
Feeling abnormal | 46.91 | 13.00 | 42 | 75550 | 54403 | 29444532 |
Hypertension | 46.60 | 13.00 | 148 | 75444 | 116466 | 29382469 |
Pruritus | 46.20 | 13.00 | 149 | 75443 | 116700 | 29382235 |
Heart rate decreased | 45.98 | 13.00 | 5 | 75587 | 24907 | 29474028 |
Somnolence | 45.96 | 13.00 | 108 | 75484 | 93847 | 29405088 |
Cytomegalovirus oesophagitis | 45.72 | 13.00 | 22 | 75570 | 394 | 29498541 |
Mobility decreased | 45.54 | 13.00 | 6 | 75586 | 25774 | 29473161 |
Oesophageal stenosis | 45.52 | 13.00 | 35 | 75557 | 1500 | 29497435 |
Leukoencephalopathy | 45.34 | 13.00 | 52 | 75540 | 3715 | 29495220 |
Renal infarct | 44.80 | 13.00 | 31 | 75561 | 1126 | 29497809 |
Influenza | 44.30 | 13.00 | 26 | 75566 | 41855 | 29457080 |
Wrong technique in product usage process | 43.68 | 13.00 | 13 | 75579 | 31415 | 29467520 |
Azoospermia | 43.25 | 13.00 | 21 | 75571 | 384 | 29498551 |
Coronary artery disease | 43.22 | 13.00 | 30 | 75562 | 44160 | 29454775 |
Therapeutic product effect decreased | 43.15 | 13.00 | 11 | 75581 | 29440 | 29469495 |
Renal impairment | 43 | 13.00 | 355 | 75237 | 80978 | 29417957 |
Colitis | 42.99 | 13.00 | 176 | 75416 | 31072 | 29467863 |
Osteosarcoma | 42.84 | 13.00 | 17 | 75575 | 186 | 29498749 |
B-cell lymphoma recurrent | 42.70 | 13.00 | 24 | 75568 | 599 | 29498336 |
Metastases to lymph nodes | 42.64 | 13.00 | 52 | 75540 | 3965 | 29494970 |
Drug hypersensitivity | 41.76 | 13.00 | 69 | 75523 | 68337 | 29430598 |
Intestinal ischaemia | 41.60 | 13.00 | 67 | 75525 | 6625 | 29492310 |
COVID-19 | 41.55 | 13.00 | 20 | 75572 | 35994 | 29462941 |
Salivary gland cancer | 41.40 | 13.00 | 18 | 75574 | 252 | 29498683 |
Radiation mucositis | 41.09 | 13.00 | 15 | 75577 | 128 | 29498807 |
Memory impairment | 40.95 | 13.00 | 21 | 75571 | 36449 | 29462486 |
Renal tubular disorder | 40.88 | 13.00 | 53 | 75539 | 4299 | 29494636 |
Lymphopenia | 40.78 | 13.00 | 100 | 75492 | 13433 | 29485502 |
Diarrhoea | 40.73 | 13.00 | 1125 | 74467 | 331573 | 29167362 |
Alopecia | 40.51 | 13.00 | 124 | 75468 | 18960 | 29479975 |
Urticaria | 40.48 | 13.00 | 48 | 75544 | 54612 | 29444323 |
Carotid artery thrombosis | 40.32 | 13.00 | 19 | 75573 | 324 | 29498611 |
Disease recurrence | 40.14 | 13.00 | 110 | 75482 | 15804 | 29483131 |
Anastomotic complication | 40.01 | 13.00 | 19 | 75573 | 330 | 29498605 |
Pulmonary arteriopathy | 39.82 | 13.00 | 13 | 75579 | 76 | 29498859 |
Angioedema | 39.54 | 13.00 | 16 | 75576 | 31899 | 29467036 |
Arthritis | 39.34 | 13.00 | 8 | 75584 | 25011 | 29473924 |
Electrocardiogram QT prolonged | 38.84 | 13.00 | 22 | 75570 | 36115 | 29462820 |
Foetal exposure during pregnancy | 38.78 | 13.00 | 19 | 75573 | 33848 | 29465087 |
Pneumatosis intestinalis | 38.57 | 13.00 | 44 | 75548 | 3125 | 29495810 |
Interstitial lung disease | 38.42 | 13.00 | 266 | 75326 | 57452 | 29441483 |
Enteritis | 38.20 | 13.00 | 65 | 75527 | 6726 | 29492209 |
Balance disorder | 37.49 | 13.00 | 23 | 75569 | 36147 | 29462788 |
Embolism | 37.47 | 13.00 | 65 | 75527 | 6831 | 29492104 |
Hypoglycaemia | 37.38 | 13.00 | 41 | 75551 | 48305 | 29450630 |
Adverse drug reaction | 37.11 | 13.00 | 8 | 75584 | 24012 | 29474923 |
Chemotherapy | 37.05 | 13.00 | 21 | 75571 | 533 | 29498402 |
Blood stem cell transplant failure | 36.76 | 13.00 | 19 | 75573 | 399 | 29498536 |
Blood pressure fluctuation | 36.69 | 13.00 | 4 | 75588 | 19890 | 29479045 |
Prostate cancer | 36.51 | 13.00 | 10 | 75582 | 25517 | 29473418 |
Tracheo-oesophageal fistula | 36.25 | 13.00 | 19 | 75573 | 411 | 29498524 |
Influenza like illness | 36.12 | 13.00 | 9 | 75583 | 24461 | 29474474 |
Large intestine perforation | 35.69 | 13.00 | 66 | 75526 | 7290 | 29491645 |
Hypoacusis | 35.69 | 13.00 | 99 | 75493 | 14324 | 29484611 |
Incorrect dose administered | 35.56 | 13.00 | 20 | 75572 | 32964 | 29465971 |
Tumour perforation | 35.51 | 13.00 | 16 | 75576 | 245 | 29498690 |
Blood sodium decreased | 35.20 | 13.00 | 100 | 75492 | 14667 | 29484268 |
Bronchial fistula | 35.05 | 13.00 | 14 | 75578 | 156 | 29498779 |
Neurosensory hypoacusis | 34.80 | 13.00 | 7 | 75585 | 0 | 29498935 |
Teratoma | 34.58 | 13.00 | 9 | 75583 | 19 | 29498916 |
Tumour haemorrhage | 34.56 | 13.00 | 37 | 75555 | 2448 | 29496487 |
Empyema | 34.53 | 13.00 | 39 | 75553 | 2740 | 29496195 |
Confusional state | 34.45 | 13.00 | 189 | 75403 | 127688 | 29371247 |
Nephrolithiasis | 34.27 | 13.00 | 11 | 75581 | 25323 | 29473612 |
Palmar-plantar erythrodysaesthesia syndrome | 34.27 | 13.00 | 99 | 75493 | 14660 | 29484275 |
Metastasis | 34.16 | 13.00 | 43 | 75549 | 3386 | 29495549 |
Respiratory failure | 34.09 | 13.00 | 389 | 75203 | 96742 | 29402193 |
Chloroma | 34.07 | 13.00 | 19 | 75573 | 467 | 29498468 |
Neoplasm recurrence | 33.98 | 13.00 | 33 | 75559 | 1944 | 29496991 |
International normalised ratio increased | 33.90 | 13.00 | 38 | 75554 | 44334 | 29454601 |
Unevaluable event | 33.80 | 13.00 | 17 | 75575 | 29834 | 29469101 |
Progressive multifocal leukoencephalopathy | 33.57 | 13.00 | 71 | 75521 | 8648 | 29490287 |
Cataract | 33.48 | 13.00 | 8 | 75584 | 22370 | 29476565 |
Flagellate dermatitis | 33.39 | 13.00 | 9 | 75583 | 23 | 29498912 |
Myocardial infarction | 32.53 | 13.00 | 158 | 75434 | 110138 | 29388797 |
Osteoarthritis | 32.49 | 13.00 | 4 | 75588 | 18099 | 29480836 |
Dyskinesia | 32.42 | 13.00 | 6 | 75586 | 20055 | 29478880 |
Recall phenomenon | 32.37 | 13.00 | 19 | 75573 | 516 | 29498419 |
Muscular weakness | 32.23 | 13.00 | 69 | 75523 | 61983 | 29436952 |
Product prescribing error | 32.19 | 13.00 | 4 | 75588 | 17972 | 29480963 |
Acquired gene mutation | 31.56 | 13.00 | 26 | 75566 | 1232 | 29497703 |
Malaise | 31.43 | 13.00 | 259 | 75333 | 159343 | 29339592 |
Rash | 31.35 | 13.00 | 322 | 75270 | 189497 | 29309438 |
Depressed mood | 31.13 | 13.00 | 3 | 75589 | 16445 | 29482490 |
Papillary thyroid cancer | 30.89 | 13.00 | 19 | 75573 | 563 | 29498372 |
Pancreatitis | 30.48 | 13.00 | 26 | 75566 | 34488 | 29464447 |
Abdominal discomfort | 30.48 | 13.00 | 47 | 75545 | 47856 | 29451079 |
Blood glucose increased | 30.29 | 13.00 | 66 | 75526 | 58918 | 29440017 |
Nasal congestion | 29.76 | 13.00 | 6 | 75586 | 18873 | 29480062 |
Arterial occlusive disease | 29.55 | 13.00 | 43 | 75549 | 3891 | 29495044 |
Osteosarcoma recurrent | 29.53 | 13.00 | 8 | 75584 | 21 | 29498914 |
Liver function test abnormal | 29.12 | 13.00 | 19 | 75573 | 28899 | 29470036 |
Pulmonary toxicity | 29.10 | 13.00 | 48 | 75544 | 4842 | 29494093 |
Oedema peripheral | 29.02 | 13.00 | 151 | 75441 | 103406 | 29395529 |
Toxicity to various agents | 28.91 | 13.00 | 294 | 75298 | 173367 | 29325568 |
Serotonin syndrome | 28.81 | 13.00 | 5 | 75587 | 17507 | 29481428 |
Hypophosphataemia | 28.76 | 13.00 | 63 | 75529 | 7861 | 29491074 |
Bicytopenia | 28.63 | 13.00 | 29 | 75563 | 1798 | 29497137 |
Pain | 28.63 | 13.00 | 290 | 75302 | 171142 | 29327793 |
Sedation | 28.57 | 13.00 | 5 | 75587 | 17400 | 29481535 |
Peritonitis | 28.42 | 13.00 | 93 | 75499 | 14731 | 29484204 |
Chest discomfort | 28.42 | 13.00 | 46 | 75546 | 45937 | 29452998 |
Mantle cell lymphoma recurrent | 28.34 | 13.00 | 17 | 75575 | 481 | 29498454 |
Chronic obstructive pulmonary disease | 28.20 | 13.00 | 38 | 75554 | 40917 | 29458018 |
Injury | 28.12 | 13.00 | 7 | 75585 | 19039 | 29479896 |
Contusion | 27.98 | 13.00 | 23 | 75569 | 31072 | 29467863 |
Erectile dysfunction | 27.82 | 13.00 | 6 | 75586 | 18003 | 29480932 |
Drug resistance | 27.81 | 13.00 | 119 | 75473 | 21421 | 29477514 |
Hepatic candidiasis | 27.80 | 13.00 | 9 | 75583 | 51 | 29498884 |
Blood HIV RNA increased | 27.46 | 13.00 | 22 | 75570 | 1002 | 29497933 |
Gout | 27.45 | 13.00 | 5 | 75587 | 16906 | 29482029 |
Bradycardia | 27.11 | 13.00 | 82 | 75510 | 65547 | 29433388 |
Extravasation | 27.05 | 13.00 | 27 | 75565 | 1645 | 29497290 |
Gait inability | 26.65 | 13.00 | 7 | 75585 | 18368 | 29480567 |
Back pain | 26.54 | 13.00 | 153 | 75439 | 102131 | 29396804 |
Abnormal behaviour | 26.44 | 13.00 | 13 | 75579 | 23114 | 29475821 |
Primitive neuroectodermal tumour | 26.32 | 13.00 | 9 | 75583 | 62 | 29498873 |
Disseminated intravascular coagulation | 26.27 | 13.00 | 111 | 75481 | 19869 | 29479066 |
Cerebral venous sinus thrombosis | 26.24 | 13.00 | 15 | 75577 | 387 | 29498548 |
Cerebral ischaemia | 26.22 | 13.00 | 50 | 75542 | 5653 | 29493282 |
Herpes zoster | 26.10 | 13.00 | 23 | 75569 | 30029 | 29468906 |
Irritability | 26.02 | 13.00 | 12 | 75580 | 22140 | 29476795 |
Blood creatinine increased | 25.57 | 13.00 | 331 | 75261 | 84771 | 29414164 |
Enterocolitis | 25.34 | 13.00 | 54 | 75538 | 6612 | 29492323 |
Arteriospasm coronary | 25.29 | 13.00 | 32 | 75560 | 2533 | 29496402 |
Loss of personal independence in daily activities | 25.23 | 13.00 | 17 | 75575 | 25423 | 29473512 |
Emotional distress | 25.11 | 13.00 | 3 | 75589 | 13892 | 29485043 |
Dermatitis acneiform | 25.07 | 13.00 | 48 | 75544 | 5443 | 29493492 |
Accidental overdose | 24.96 | 13.00 | 7 | 75585 | 17586 | 29481349 |
Pneumothorax | 24.84 | 13.00 | 93 | 75499 | 15749 | 29483186 |
Sleep disorder | 24.59 | 13.00 | 16 | 75576 | 24370 | 29474565 |
Angina pectoris | 24.57 | 13.00 | 21 | 75571 | 27829 | 29471106 |
Lymphadenopathy mediastinal | 24.53 | 13.00 | 29 | 75563 | 2140 | 29496795 |
Radiation injury | 24.49 | 13.00 | 15 | 75577 | 441 | 29498494 |
Fluid retention | 24.38 | 13.00 | 15 | 75577 | 23545 | 29475390 |
Cerebral infarction | 24.29 | 13.00 | 126 | 75466 | 24549 | 29474386 |
Refeeding syndrome | 24.23 | 13.00 | 7 | 75585 | 25 | 29498910 |
Oesophageal perforation | 24.13 | 13.00 | 18 | 75574 | 737 | 29498198 |
Lactic acidosis | 24.11 | 13.00 | 25 | 75567 | 30222 | 29468713 |
Therapy cessation | 24.08 | 13.00 | 4 | 75588 | 14458 | 29484477 |
Testicular malignant teratoma | 23.97 | 13.00 | 6 | 75586 | 10 | 29498925 |
Refractory cancer | 23.87 | 13.00 | 10 | 75582 | 127 | 29498808 |
Product administration error | 23.73 | 13.00 | 4 | 75588 | 14306 | 29484629 |
Pharyngeal inflammation | 23.55 | 13.00 | 13 | 75579 | 313 | 29498622 |
Diabetes mellitus | 23.54 | 13.00 | 41 | 75551 | 39790 | 29459145 |
Retinal toxicity | 23.53 | 13.00 | 14 | 75578 | 390 | 29498545 |
Sinusitis | 23.52 | 13.00 | 32 | 75560 | 34318 | 29464617 |
Diaphragm muscle weakness | 23.32 | 13.00 | 10 | 75582 | 135 | 29498800 |
Necrosis | 23.00 | 13.00 | 44 | 75548 | 4986 | 29493949 |
Gastrooesophageal reflux disease | 22.95 | 13.00 | 28 | 75564 | 31468 | 29467467 |
Blindness cortical | 22.86 | 13.00 | 13 | 75579 | 332 | 29498603 |
Localised infection | 22.61 | 13.00 | 4 | 75588 | 13812 | 29485123 |
Blood cholesterol increased | 22.51 | 13.00 | 6 | 75586 | 15589 | 29483346 |
Granulocyte count decreased | 22.49 | 13.00 | 16 | 75576 | 608 | 29498327 |
Road traffic accident | 22.43 | 13.00 | 6 | 75586 | 15555 | 29483380 |
Haematoma | 22.37 | 13.00 | 16 | 75576 | 23196 | 29475739 |
Oral candidiasis | 22.13 | 13.00 | 69 | 75523 | 10653 | 29488282 |
Cholelithiasis | 22.11 | 13.00 | 10 | 75582 | 18662 | 29480273 |
Hypochloraemia | 22.09 | 13.00 | 15 | 75577 | 528 | 29498407 |
Agitation | 21.98 | 13.00 | 63 | 75529 | 51241 | 29447694 |
Granulocyte-colony stimulating factor level increased | 21.93 | 13.00 | 5 | 75587 | 4 | 29498931 |
Morphoea | 21.80 | 13.00 | 10 | 75582 | 160 | 29498775 |
Gastrointestinal ischaemia | 21.80 | 13.00 | 10 | 75582 | 160 | 29498775 |
Superior mesenteric artery syndrome | 21.74 | 13.00 | 8 | 75584 | 70 | 29498865 |
Pleural effusion | 21.73 | 13.00 | 280 | 75312 | 71628 | 29427307 |
Sleep apnoea syndrome | 21.51 | 13.00 | 9 | 75583 | 17590 | 29481345 |
Myoclonus | 21.46 | 13.00 | 4 | 75588 | 13305 | 29485630 |
Necrosis ischaemic | 21.45 | 13.00 | 11 | 75581 | 227 | 29498708 |
Soft tissue disorder | 21.43 | 13.00 | 16 | 75576 | 656 | 29498279 |
Performance status decreased | 21.39 | 13.00 | 36 | 75556 | 3691 | 29495244 |
Coronary artery thrombosis | 21.35 | 13.00 | 26 | 75566 | 1979 | 29496956 |
Labelled drug-drug interaction medication error | 21.07 | 13.00 | 3 | 75589 | 12156 | 29486779 |
Blood glucose decreased | 20.86 | 13.00 | 3 | 75589 | 12066 | 29486869 |
Wound | 20.85 | 13.00 | 3 | 75589 | 12060 | 29486875 |
Extremity necrosis | 20.78 | 13.00 | 23 | 75569 | 1580 | 29497355 |
Embolism arterial | 20.67 | 13.00 | 14 | 75578 | 491 | 29498444 |
Choriocarcinoma | 20.50 | 13.00 | 5 | 75587 | 7 | 29498928 |
Underdose | 20.40 | 13.00 | 3 | 75589 | 11866 | 29487069 |
Vascular injury | 20.34 | 13.00 | 11 | 75581 | 254 | 29498681 |
Neutrophil count abnormal | 20.09 | 13.00 | 22 | 75570 | 1493 | 29497442 |
Hypoalbuminaemia | 20.07 | 13.00 | 65 | 75527 | 10240 | 29488695 |
Metastases to peritoneum | 20.03 | 13.00 | 22 | 75570 | 1498 | 29497437 |
Blood pressure systolic increased | 19.98 | 13.00 | 9 | 75583 | 16836 | 29482099 |
Hyperammonaemic encephalopathy | 19.90 | 13.00 | 25 | 75567 | 1965 | 29496970 |
Neurotoxicity | 19.85 | 13.00 | 82 | 75510 | 14531 | 29484404 |
Full blood count decreased | 19.83 | 13.00 | 8 | 75584 | 15984 | 29482951 |
Deafness bilateral | 19.83 | 13.00 | 18 | 75574 | 973 | 29497962 |
Metastases to skin | 19.80 | 13.00 | 12 | 75580 | 346 | 29498589 |
Palpitations | 19.78 | 13.00 | 33 | 75559 | 32571 | 29466364 |
Iliac artery occlusion | 19.67 | 13.00 | 9 | 75583 | 143 | 29498792 |
Product quality issue | 19.63 | 13.00 | 8 | 75584 | 15887 | 29483048 |
Blood lactate dehydrogenase increased | 19.54 | 13.00 | 99 | 75493 | 19110 | 29479825 |
Carotid artery dissection | 19.51 | 13.00 | 9 | 75583 | 146 | 29498789 |
Adrenocortical carcinoma | 19.50 | 13.00 | 6 | 75586 | 28 | 29498907 |
Mitral valve incompetence | 19.40 | 13.00 | 5 | 75587 | 13288 | 29485647 |
Procedural vomiting | 19.39 | 13.00 | 9 | 75583 | 148 | 29498787 |
Campylobacter test positive | 19.32 | 13.00 | 6 | 75586 | 29 | 29498906 |
Hyperhidrosis | 19.28 | 13.00 | 92 | 75500 | 64448 | 29434487 |
Failure to thrive | 19.26 | 13.00 | 53 | 75539 | 7631 | 29491304 |
Speech disorder | 19.24 | 13.00 | 19 | 75573 | 23497 | 29475438 |
Hot flush | 19.17 | 13.00 | 7 | 75585 | 14863 | 29484072 |
Cell-mediated immune deficiency | 19.16 | 13.00 | 6 | 75586 | 30 | 29498905 |
Transitional cell carcinoma recurrent | 19.07 | 13.00 | 5 | 75587 | 11 | 29498924 |
Laryngeal pain | 18.85 | 13.00 | 28 | 75564 | 2580 | 29496355 |
Medulloblastoma recurrent | 18.85 | 13.00 | 7 | 75585 | 63 | 29498872 |
Transient ischaemic attack | 18.81 | 13.00 | 19 | 75573 | 23251 | 29475684 |
Transformation to acute myeloid leukaemia | 18.78 | 13.00 | 15 | 75577 | 680 | 29498255 |
EGFR gene mutation | 18.66 | 13.00 | 8 | 75584 | 108 | 29498827 |
Loss of consciousness | 18.55 | 13.00 | 112 | 75480 | 73944 | 29424991 |
Swelling | 18.51 | 13.00 | 39 | 75553 | 35244 | 29463691 |
Haematochezia | 18.48 | 13.00 | 42 | 75550 | 36941 | 29461994 |
Procedural nausea | 18.47 | 13.00 | 7 | 75585 | 67 | 29498868 |
Psychotic disorder | 18.38 | 13.00 | 15 | 75577 | 20339 | 29478596 |
Urinary tract infection | 18.35 | 13.00 | 109 | 75483 | 72245 | 29426690 |
Chromaturia | 18.33 | 13.00 | 5 | 75587 | 12797 | 29486138 |
Hepatitis B reactivation | 18.28 | 13.00 | 31 | 75561 | 3198 | 29495737 |
Intestinal infarction | 18.27 | 13.00 | 13 | 75579 | 494 | 29498441 |
Upper respiratory tract infection | 18.20 | 13.00 | 26 | 75566 | 27323 | 29471612 |
Peripheral sensory neuropathy | 18.01 | 13.00 | 44 | 75548 | 5895 | 29493040 |
Venous thrombosis | 18.00 | 13.00 | 30 | 75562 | 3052 | 29495883 |
Meningitis tuberculous | 17.99 | 13.00 | 14 | 75578 | 611 | 29498324 |
Visceral venous thrombosis | 17.97 | 13.00 | 5 | 75587 | 15 | 29498920 |
Hypoaesthesia | 17.91 | 13.00 | 73 | 75519 | 53394 | 29445541 |
Disturbance in attention | 17.88 | 13.00 | 17 | 75575 | 21407 | 29477528 |
Hyperlipidaemia | 17.88 | 13.00 | 5 | 75587 | 12585 | 29486350 |
Gastrointestinal perforation | 17.85 | 13.00 | 32 | 75560 | 3451 | 29495484 |
Accidental exposure to product | 17.84 | 13.00 | 3 | 75589 | 10750 | 29488185 |
Cerebral venous thrombosis | 17.73 | 13.00 | 14 | 75578 | 624 | 29498311 |
Ureteric dilatation | 17.67 | 13.00 | 8 | 75584 | 124 | 29498811 |
Drug clearance decreased | 17.65 | 13.00 | 20 | 75572 | 1410 | 29497525 |
Oesophageal pain | 17.64 | 13.00 | 15 | 75577 | 743 | 29498192 |
Haemoptysis | 17.57 | 13.00 | 136 | 75456 | 30414 | 29468521 |
Dermatitis diaper | 17.53 | 13.00 | 10 | 75582 | 257 | 29498678 |
Drug intolerance | 17.53 | 13.00 | 64 | 75528 | 48315 | 29450620 |
Bronchitis | 17.51 | 13.00 | 43 | 75549 | 36825 | 29462110 |
Fanconi syndrome | 17.47 | 13.00 | 21 | 75571 | 1577 | 29497358 |
Mucosal toxicity | 17.37 | 13.00 | 9 | 75583 | 190 | 29498745 |
Injection site erythema | 17.28 | 13.00 | 7 | 75585 | 13949 | 29484986 |
Blood creatinine | 17.22 | 13.00 | 6 | 75586 | 44 | 29498891 |
Dysstasia | 17.21 | 13.00 | 3 | 75589 | 10471 | 29488464 |
Gastrointestinal anastomotic leak | 17.19 | 13.00 | 11 | 75581 | 350 | 29498585 |
Visual impairment | 17.18 | 13.00 | 31 | 75561 | 29677 | 29469258 |
Traumatic lung injury | 17.17 | 13.00 | 18 | 75574 | 1162 | 29497773 |
Trigeminal nerve paresis | 17.13 | 13.00 | 4 | 75588 | 4 | 29498931 |
Metastases to bone | 17.12 | 13.00 | 60 | 75532 | 9838 | 29489097 |
B-cell lymphoma refractory | 17 | 13.00 | 8 | 75584 | 136 | 29498799 |
Gingivitis ulcerative | 16.99 | 13.00 | 6 | 75586 | 46 | 29498889 |
Chemotherapeutic drug level increased | 16.91 | 13.00 | 9 | 75583 | 201 | 29498734 |
Human chorionic gonadotropin increased | 16.86 | 13.00 | 5 | 75587 | 20 | 29498915 |
Metastases to meninges | 16.86 | 13.00 | 18 | 75574 | 1187 | 29497748 |
Delusion | 16.79 | 13.00 | 4 | 75588 | 11212 | 29487723 |
Lymphangiosis carcinomatosa | 16.75 | 13.00 | 15 | 75577 | 797 | 29498138 |
Burning sensation | 16.70 | 13.00 | 10 | 75582 | 15928 | 29483007 |
Movement disorder | 16.67 | 13.00 | 3 | 75589 | 10234 | 29488701 |
Type 2 diabetes mellitus | 16.51 | 13.00 | 7 | 75585 | 13574 | 29485361 |
Myelitis transverse | 16.38 | 13.00 | 16 | 75576 | 949 | 29497986 |
Blister | 16.38 | 13.00 | 16 | 75576 | 19890 | 29479045 |
Withdrawal syndrome | 16.30 | 13.00 | 4 | 75588 | 10988 | 29487947 |
Thrombocytosis | 16.16 | 13.00 | 30 | 75562 | 3323 | 29495612 |
Subcutaneous emphysema | 16.01 | 13.00 | 16 | 75576 | 976 | 29497959 |
Swelling face | 16.01 | 13.00 | 17 | 75575 | 20333 | 29478602 |
Wound evisceration | 15.97 | 13.00 | 7 | 75585 | 100 | 29498835 |
Small cell lung cancer | 15.93 | 13.00 | 21 | 75571 | 1731 | 29497204 |
Dementia | 15.88 | 13.00 | 5 | 75587 | 11653 | 29487282 |
Rectal haemorrhage | 15.87 | 13.00 | 41 | 75551 | 34508 | 29464427 |
Hypersomnia | 15.78 | 13.00 | 4 | 75588 | 10750 | 29488185 |
Tumour thrombosis | 15.78 | 13.00 | 6 | 75586 | 58 | 29498877 |
Eye pain | 15.74 | 13.00 | 5 | 75587 | 11590 | 29487345 |
Hepatic enzyme increased | 15.60 | 13.00 | 40 | 75552 | 33759 | 29465176 |
Testicular cancer metastatic | 15.60 | 13.00 | 6 | 75586 | 60 | 29498875 |
Testicular germ cell cancer metastatic | 15.60 | 13.00 | 6 | 75586 | 60 | 29498875 |
Ganglioneuroma | 15.51 | 13.00 | 4 | 75588 | 8 | 29498927 |
Gene mutation | 15.37 | 13.00 | 16 | 75576 | 1025 | 29497910 |
Blood magnesium decreased | 15.35 | 13.00 | 39 | 75553 | 5355 | 29493580 |
Blastic plasmacytoid dendritic cell neoplasia | 15.26 | 13.00 | 6 | 75586 | 64 | 29498871 |
Osteosarcoma metastatic | 15.20 | 13.00 | 4 | 75588 | 9 | 29498926 |
Plasma cell leukaemia | 15.02 | 13.00 | 14 | 75578 | 783 | 29498152 |
Immune-mediated hepatic disorder | 15.01 | 13.00 | 10 | 75582 | 341 | 29498594 |
Hyperglycaemic hyperosmolar nonketotic syndrome | 15 | 13.00 | 16 | 75576 | 1054 | 29497881 |
Blood triglycerides increased | 15.00 | 13.00 | 7 | 75585 | 12827 | 29486108 |
Enterococcal bacteraemia | 14.92 | 13.00 | 19 | 75573 | 1514 | 29497421 |
Carotid artery perforation | 14.92 | 13.00 | 3 | 75589 | 0 | 29498935 |
Pharyngeal stenosis | 14.92 | 13.00 | 3 | 75589 | 0 | 29498935 |
Plasma cell myeloma | 14.87 | 13.00 | 47 | 75545 | 37068 | 29461867 |
Respiratory depression | 14.86 | 13.00 | 8 | 75584 | 13515 | 29485420 |
Viral load increased | 14.82 | 13.00 | 22 | 75570 | 2027 | 29496908 |
Eosinophilia | 14.81 | 13.00 | 21 | 75571 | 22140 | 29476795 |
Hepatic steatosis | 14.80 | 13.00 | 10 | 75582 | 14936 | 29483999 |
Dyspnoea exertional | 14.77 | 13.00 | 46 | 75546 | 36444 | 29462491 |
Rib fracture | 14.76 | 13.00 | 7 | 75585 | 12711 | 29486224 |
Cerebral haemorrhage | 14.66 | 13.00 | 37 | 75555 | 31389 | 29467546 |
JC virus infection | 14.63 | 13.00 | 21 | 75571 | 1876 | 29497059 |
Basal cell carcinoma | 14.61 | 13.00 | 13 | 75579 | 16897 | 29482038 |
Thrombotic thrombocytopenic purpura | 14.60 | 13.00 | 28 | 75564 | 3178 | 29495757 |
Laboratory test abnormal | 14.52 | 13.00 | 15 | 75577 | 18170 | 29480765 |
Haemoperitoneum | 14.44 | 13.00 | 19 | 75573 | 1563 | 29497372 |
Apparent mineralocorticoid excess | 14.43 | 13.00 | 5 | 75587 | 36 | 29498899 |
Frequent bowel movements | 14.43 | 13.00 | 3 | 75589 | 9236 | 29489699 |
White blood cell disorder | 14.42 | 13.00 | 18 | 75574 | 1405 | 29497530 |
Infected neoplasm | 14.41 | 13.00 | 6 | 75586 | 75 | 29498860 |
Metapneumovirus bronchiolitis | 14.37 | 13.00 | 4 | 75588 | 12 | 29498923 |
Head injury | 14.33 | 13.00 | 12 | 75580 | 16069 | 29482866 |
Diabetic ketoacidosis | 14.32 | 13.00 | 12 | 75580 | 16061 | 29482874 |
Dropped head syndrome | 14.27 | 13.00 | 7 | 75585 | 131 | 29498804 |
Treatment noncompliance | 14.26 | 13.00 | 25 | 75567 | 24202 | 29474733 |
Sarcoma | 14.24 | 13.00 | 10 | 75582 | 372 | 29498563 |
Penile vein thrombosis | 14.13 | 13.00 | 4 | 75588 | 13 | 29498922 |
Cerebrovascular accident | 14.13 | 13.00 | 127 | 75465 | 76784 | 29422151 |
Polyneuropathy | 14.07 | 13.00 | 65 | 75527 | 12087 | 29486848 |
Malocclusion | 14.06 | 13.00 | 6 | 75586 | 80 | 29498855 |
Eczema | 14.03 | 13.00 | 9 | 75583 | 13817 | 29485118 |
Fistula of small intestine | 13.94 | 13.00 | 10 | 75582 | 385 | 29498550 |
Laryngeal cancer stage IV | 13.91 | 13.00 | 4 | 75588 | 14 | 29498921 |
Gastrointestinal haemorrhage | 13.89 | 13.00 | 133 | 75459 | 79400 | 29419535 |
Paranoia | 13.88 | 13.00 | 4 | 75588 | 9873 | 29489062 |
Therapeutic embolisation | 13.85 | 13.00 | 9 | 75583 | 294 | 29498641 |
Osteomyelitis | 13.81 | 13.00 | 9 | 75583 | 13700 | 29485235 |
Candida infection | 13.80 | 13.00 | 76 | 75516 | 15149 | 29483786 |
Thrombophlebitis migrans | 13.73 | 13.00 | 6 | 75586 | 85 | 29498850 |
Metastatic gastric cancer | 13.59 | 13.00 | 7 | 75585 | 146 | 29498789 |
Focal nodular hyperplasia | 13.50 | 13.00 | 7 | 75585 | 148 | 29498787 |
Torulopsis infection | 13.49 | 13.00 | 4 | 75588 | 16 | 29498919 |
Optic atrophy | 13.45 | 13.00 | 13 | 75579 | 761 | 29498174 |
Subdural haematoma | 13.44 | 13.00 | 16 | 75576 | 18177 | 29480758 |
Fistula | 13.44 | 13.00 | 36 | 75556 | 5103 | 29493832 |
Hip fracture | 13.42 | 13.00 | 5 | 75587 | 10487 | 29488448 |
Chondrosarcoma | 13.37 | 13.00 | 5 | 75587 | 46 | 29498889 |
Hemianopia | 13.34 | 13.00 | 12 | 75580 | 641 | 29498294 |
Cellulitis | 13.30 | 13.00 | 66 | 75526 | 45774 | 29453161 |
Oral pain | 13.25 | 13.00 | 53 | 75539 | 9254 | 29489681 |
Tetany | 13.20 | 13.00 | 12 | 75580 | 650 | 29498285 |
Abdominal wound dehiscence | 13.19 | 13.00 | 6 | 75586 | 94 | 29498841 |
Tracheal stenosis | 13.17 | 13.00 | 7 | 75585 | 156 | 29498779 |
Tooth disorder | 13.13 | 13.00 | 4 | 75588 | 9525 | 29489410 |
Cytopenia | 13.13 | 13.00 | 55 | 75537 | 9804 | 29489131 |
Laryngeal inflammation | 13.12 | 13.00 | 4 | 75588 | 18 | 29498917 |
Decorticate posture | 13.12 | 13.00 | 4 | 75588 | 18 | 29498917 |
Retinal ischaemia | 13.00 | 13.00 | 9 | 75583 | 327 | 29498608 |
MedDRA adverse event term | Likelihood ratio | Likelihood ratio threshold | Patients taking drug having adverse event | Patients taking drug not having adverse event | Patients not taking drug having adverse event | Patients not taking drug not having adverse event |
---|---|---|---|---|---|---|
Febrile neutropenia | 2189.66 | 12.76 | 2112 | 109007 | 185545 | 64202068 |
Neutropenia | 1587.98 | 12.76 | 2005 | 109114 | 237619 | 64149994 |
Thrombocytopenia | 1116.79 | 12.76 | 1633 | 109486 | 222168 | 64165445 |
Mucosal inflammation | 1038.22 | 12.76 | 861 | 110258 | 61723 | 64325890 |
Malignant neoplasm progression | 901.53 | 12.76 | 1040 | 110079 | 111831 | 64275782 |
Bone marrow failure | 742.01 | 12.76 | 634 | 110485 | 47318 | 64340295 |
Pancytopenia | 725.60 | 12.76 | 1054 | 110065 | 142255 | 64245358 |
Haematotoxicity | 637.67 | 12.76 | 350 | 110769 | 12546 | 64375067 |
Disease progression | 630.16 | 12.76 | 981 | 110138 | 140699 | 64246914 |
Leukopenia | 509.66 | 12.76 | 743 | 110376 | 100499 | 64287114 |
Myelosuppression | 509.40 | 12.76 | 381 | 110738 | 23449 | 64364164 |
Acute myeloid leukaemia | 506.02 | 12.76 | 402 | 110717 | 27061 | 64360552 |
Anaemia | 490.94 | 12.76 | 1599 | 109520 | 377081 | 64010532 |
Dehydration | 470.70 | 12.76 | 1106 | 110013 | 215657 | 64171956 |
Vomiting | 468.13 | 12.76 | 2031 | 109088 | 549086 | 63838527 |
Arthralgia | 421.99 | 12.76 | 120 | 110999 | 442140 | 63945473 |
Second primary malignancy | 402.59 | 12.76 | 256 | 110863 | 12081 | 64375532 |
Nausea | 352.98 | 12.76 | 2434 | 108685 | 783366 | 63604247 |
Neutropenic sepsis | 344.17 | 12.76 | 300 | 110819 | 22972 | 64364641 |
Off label use | 324.96 | 12.76 | 2028 | 109091 | 630778 | 63756835 |
Aortic thrombosis | 319.30 | 12.76 | 114 | 111005 | 1400 | 64386213 |
Renal salt-wasting syndrome | 317.16 | 12.76 | 86 | 111033 | 378 | 64387235 |
Neutrophil count decreased | 313.18 | 12.76 | 513 | 110606 | 76683 | 64310930 |
Fall | 301.65 | 12.76 | 172 | 110947 | 416654 | 63970959 |
Ototoxicity | 293.37 | 12.76 | 126 | 110993 | 2597 | 64385016 |
Neoplasm progression | 273.39 | 12.76 | 345 | 110774 | 40619 | 64346994 |
Joint swelling | 263.63 | 12.76 | 31 | 111088 | 215351 | 64172262 |
Hypomagnesaemia | 262.59 | 12.76 | 323 | 110796 | 37053 | 64350560 |
Myelodysplastic syndrome | 253.83 | 12.76 | 274 | 110845 | 27305 | 64360308 |
Rheumatoid arthritis | 250.49 | 12.76 | 7 | 111112 | 164287 | 64223326 |
Pulmonary embolism | 243.62 | 12.76 | 676 | 110443 | 145680 | 64241933 |
Product dose omission issue | 243.45 | 12.76 | 26 | 111093 | 194721 | 64192892 |
Nephropathy toxic | 241.46 | 12.76 | 217 | 110902 | 17297 | 64370316 |
Pyrexia | 230.92 | 12.76 | 1698 | 109421 | 556946 | 63830667 |
Acute kidney injury | 226.29 | 12.76 | 1434 | 109685 | 447806 | 63939807 |
Drug abuse | 208.11 | 12.76 | 4 | 111115 | 132370 | 64255243 |
Peripheral swelling | 208.10 | 12.76 | 52 | 111067 | 209101 | 64178512 |
Headache | 202.47 | 12.76 | 378 | 110741 | 529089 | 63858524 |
Deafness | 195.09 | 12.76 | 197 | 110922 | 18162 | 64369451 |
Weight increased | 193.86 | 12.76 | 63 | 111056 | 213285 | 64174328 |
Cardiotoxicity | 192.63 | 12.76 | 152 | 110967 | 10122 | 64377491 |
Pain | 187.21 | 12.76 | 424 | 110695 | 553087 | 63834526 |
Tumour lysis syndrome | 185.68 | 12.76 | 197 | 110922 | 19243 | 64368370 |
Platelet count decreased | 183.96 | 12.76 | 671 | 110448 | 167040 | 64220573 |
Dysphagia | 180.26 | 12.76 | 496 | 110623 | 106316 | 64281297 |
Sepsis | 180.15 | 12.76 | 830 | 110289 | 229511 | 64158102 |
Posterior reversible encephalopathy syndrome | 178.70 | 12.76 | 209 | 110910 | 22737 | 64364876 |
Decreased appetite | 175.73 | 12.76 | 951 | 110168 | 280338 | 64107275 |
Stomatitis | 175.17 | 12.76 | 499 | 110620 | 109106 | 64278507 |
Septic shock | 174.36 | 12.76 | 486 | 110633 | 104951 | 64282662 |
Therapy partial responder | 173.85 | 12.76 | 143 | 110976 | 10105 | 64377508 |
Metastases to lung | 173.67 | 12.76 | 170 | 110949 | 15094 | 64372519 |
Musculoskeletal stiffness | 171.89 | 12.76 | 10 | 111109 | 123196 | 64264417 |
Metastases to central nervous system | 171.62 | 12.76 | 162 | 110957 | 13750 | 64373863 |
Anastomotic leak | 171.25 | 12.76 | 64 | 111055 | 902 | 64386711 |
Arthropathy | 168.21 | 12.76 | 10 | 111109 | 120957 | 64266656 |
Nasopharyngitis | 162.74 | 12.76 | 67 | 111052 | 196006 | 64191607 |
Product use in unapproved indication | 162.15 | 12.76 | 668 | 110451 | 175950 | 64211663 |
Drug hypersensitivity | 160.81 | 12.76 | 106 | 111013 | 237709 | 64149904 |
Pain in extremity | 158.60 | 12.76 | 173 | 110946 | 302912 | 64084701 |
Hypokalaemia | 158.28 | 12.76 | 516 | 110603 | 121387 | 64266226 |
White blood cell count decreased | 157.72 | 12.76 | 613 | 110506 | 157224 | 64230389 |
Tinnitus | 155.09 | 12.76 | 239 | 110880 | 33894 | 64353719 |
Hyponatraemia | 154.69 | 12.76 | 584 | 110535 | 147755 | 64239858 |
Diffuse large B-cell lymphoma recurrent | 148.93 | 12.76 | 83 | 111036 | 3063 | 64384550 |
Oesophagitis | 148.79 | 12.76 | 185 | 110934 | 21445 | 64366168 |
Overdose | 145.12 | 12.76 | 47 | 111072 | 159519 | 64228094 |
Abdominal discomfort | 140.80 | 12.76 | 69 | 111050 | 182253 | 64205360 |
Injection site pain | 138.84 | 12.76 | 15 | 111104 | 111393 | 64276220 |
Radiation skin injury | 134.96 | 12.76 | 59 | 111060 | 1271 | 64386342 |
Therapeutic product effect decreased | 132.95 | 12.76 | 20 | 111099 | 115331 | 64272282 |
Renal failure | 131.96 | 12.76 | 641 | 110478 | 181047 | 64206566 |
Teratoma | 131.94 | 12.76 | 34 | 111085 | 117 | 64387496 |
Neuropathy peripheral | 131.14 | 12.76 | 473 | 110646 | 117052 | 64270561 |
Drug resistance | 129.91 | 12.76 | 224 | 110895 | 34878 | 64352735 |
Gastrointestinal toxicity | 129.35 | 12.76 | 92 | 111027 | 5230 | 64382383 |
Insomnia | 126.03 | 12.76 | 94 | 111025 | 197742 | 64189871 |
Condition aggravated | 123.49 | 12.76 | 288 | 110831 | 372138 | 64015475 |
Pruritus | 121.85 | 12.76 | 220 | 110899 | 312180 | 64075433 |
Hypophagia | 120.36 | 12.76 | 232 | 110887 | 39355 | 64348258 |
Inappropriate antidiuretic hormone secretion | 119.91 | 12.76 | 169 | 110950 | 22120 | 64365493 |
Peripheral artery thrombosis | 119.89 | 12.76 | 71 | 111048 | 2944 | 64384669 |
Muscle spasms | 117.29 | 12.76 | 48 | 111071 | 140975 | 64246638 |
Febrile bone marrow aplasia | 116.34 | 12.76 | 119 | 111000 | 11136 | 64376477 |
Oesophageal fistula | 116.01 | 12.76 | 36 | 111083 | 275 | 64387338 |
Swelling | 115.79 | 12.76 | 66 | 111053 | 160152 | 64227461 |
Systemic lupus erythematosus | 115.75 | 12.76 | 4 | 111115 | 77608 | 64310005 |
Metastases to lymph nodes | 112.31 | 12.76 | 104 | 111015 | 8613 | 64379000 |
Aorto-oesophageal fistula | 111.03 | 12.76 | 26 | 111093 | 52 | 64387561 |
Asthma | 110.91 | 12.76 | 16 | 111103 | 95209 | 64292404 |
Hypocalcaemia | 108.22 | 12.76 | 229 | 110890 | 41524 | 64346089 |
Diffuse large B-cell lymphoma refractory | 108.04 | 12.76 | 48 | 111071 | 1076 | 64386537 |
Arthritis | 107.78 | 12.76 | 10 | 111109 | 83804 | 64303809 |
Gastric perforation | 107.25 | 12.76 | 70 | 111049 | 3453 | 64384160 |
Contusion | 106.41 | 12.76 | 32 | 111087 | 113933 | 64273680 |
Ovarian germ cell teratoma | 105.79 | 12.76 | 25 | 111094 | 53 | 64387560 |
Drug ineffective | 105.53 | 12.76 | 934 | 110185 | 839313 | 63548300 |
Disease recurrence | 104.91 | 12.76 | 192 | 110927 | 31318 | 64356295 |
Depression | 102.16 | 12.76 | 99 | 111020 | 183192 | 64204421 |
Leukoencephalopathy | 101.34 | 12.76 | 89 | 111030 | 6878 | 64380735 |
Intentional product misuse | 100.42 | 12.76 | 6 | 111113 | 72289 | 64315324 |
Palmar-plantar erythrodysaesthesia syndrome | 100.27 | 12.76 | 179 | 110940 | 28640 | 64358973 |
Deep vein thrombosis | 99.74 | 12.76 | 402 | 110717 | 104780 | 64282833 |
Metastases to liver | 99.57 | 12.76 | 161 | 110958 | 23780 | 64363833 |
Renal tubular disorder | 98.34 | 12.76 | 82 | 111037 | 5905 | 64381708 |
Venoocclusive liver disease | 96.53 | 12.76 | 102 | 111017 | 9913 | 64377700 |
Psoriasis | 96.50 | 12.76 | 7 | 111112 | 71696 | 64315917 |
Contraindicated product administered | 94.14 | 12.76 | 34 | 111085 | 107795 | 64279818 |
Drug interaction | 93.32 | 12.76 | 316 | 110803 | 361767 | 64025846 |
Odynophagia | 92.59 | 12.76 | 98 | 111021 | 9543 | 64378070 |
Wound | 91.07 | 12.76 | 12 | 111107 | 76465 | 64311148 |
Peripheral ischaemia | 91.02 | 12.76 | 91 | 111028 | 8287 | 64379326 |
Suicidal ideation | 90.99 | 12.76 | 6 | 111113 | 66536 | 64321077 |
Pemphigus | 90.97 | 12.76 | 3 | 111116 | 60698 | 64326915 |
Arterial thrombosis | 90.85 | 12.76 | 55 | 111064 | 2375 | 64385238 |
Hypoacusis | 90.43 | 12.76 | 161 | 110958 | 25706 | 64361907 |
Mobility decreased | 89.97 | 12.76 | 19 | 111100 | 85821 | 64301792 |
Sinusitis | 89.52 | 12.76 | 72 | 111047 | 145856 | 64241757 |
Hiccups | 89.20 | 12.76 | 90 | 111029 | 8286 | 64379327 |
Dermatitis | 88.65 | 12.76 | 131 | 110988 | 17898 | 64369715 |
Renal impairment | 88.56 | 12.76 | 463 | 110656 | 134554 | 64253059 |
Gait disturbance | 88.05 | 12.76 | 100 | 111019 | 172055 | 64215558 |
Neurotoxicity | 87.49 | 12.76 | 164 | 110955 | 27240 | 64360373 |
Electrolyte imbalance | 86.81 | 12.76 | 156 | 110963 | 25087 | 64362526 |
Radiation pneumonitis | 86.63 | 12.76 | 60 | 111059 | 3268 | 64384345 |
Anxiety | 86.06 | 12.76 | 135 | 110984 | 202514 | 64185099 |
Dizziness | 85.94 | 12.76 | 415 | 110704 | 429748 | 63957865 |
Malignant transformation | 85.52 | 12.76 | 41 | 111078 | 1100 | 64386513 |
Urogenital fistula | 85.09 | 12.76 | 22 | 111097 | 77 | 64387536 |
Rash | 83.91 | 12.76 | 456 | 110663 | 458093 | 63929520 |
Urticaria | 83.91 | 12.76 | 78 | 111041 | 147239 | 64240374 |
Osteoarthritis | 82.94 | 12.76 | 7 | 111112 | 63329 | 64324284 |
Teratoma benign | 79.44 | 12.76 | 20 | 111099 | 61 | 64387552 |
Migraine | 79.21 | 12.76 | 8 | 111111 | 62669 | 64324944 |
Bacteraemia | 78.49 | 12.76 | 155 | 110964 | 26756 | 64360857 |
Feeling abnormal | 78.16 | 12.76 | 69 | 111050 | 133533 | 64254080 |
Hospitalisation | 78.10 | 12.76 | 17 | 111102 | 75190 | 64312423 |
Suicide attempt | 78.04 | 12.76 | 14 | 111105 | 70993 | 64316620 |
Recall phenomenon | 78.00 | 12.76 | 37 | 111082 | 969 | 64386644 |
Blood pressure increased | 77.08 | 12.76 | 111 | 111008 | 172441 | 64215172 |
Blister | 76.92 | 12.76 | 22 | 111097 | 80945 | 64306668 |
Somnolence | 76.15 | 12.76 | 147 | 110972 | 203498 | 64184115 |
Cardiac failure congestive | 75.72 | 12.76 | 68 | 111051 | 130512 | 64257101 |
Injection site erythema | 75.59 | 12.76 | 15 | 111104 | 70785 | 64316828 |
Acute respiratory distress syndrome | 74.97 | 12.76 | 190 | 110929 | 38745 | 64348868 |
Myalgia | 74.91 | 12.76 | 98 | 111021 | 158519 | 64229094 |
Diarrhoea | 74.19 | 12.76 | 1696 | 109423 | 721008 | 63666605 |
Osteoradionecrosis | 73.55 | 12.76 | 20 | 111099 | 89 | 64387524 |
Stress | 73.28 | 12.76 | 9 | 111110 | 60525 | 64327088 |
Bronchitis | 72.72 | 12.76 | 49 | 111070 | 108694 | 64278919 |
Balance disorder | 72.34 | 12.76 | 27 | 111092 | 83899 | 64303714 |
Nasal congestion | 71.90 | 12.76 | 9 | 111110 | 59649 | 64327964 |
Enteritis | 71.62 | 12.76 | 96 | 111023 | 11981 | 64375632 |
Hepatic enzyme increased | 71.44 | 12.76 | 71 | 111048 | 129872 | 64257741 |
Wheezing | 71.02 | 12.76 | 25 | 111094 | 80554 | 64307059 |
Pneumonitis | 70.60 | 12.76 | 219 | 110900 | 50146 | 64337467 |
Drug intolerance | 69.16 | 12.76 | 137 | 110982 | 187855 | 64199758 |
Deafness bilateral | 68.95 | 12.76 | 42 | 111077 | 1834 | 64385779 |
Rhabdomyolysis | 68.84 | 12.76 | 36 | 111083 | 91690 | 64295923 |
Pulmonary vascular disorder | 68.47 | 12.76 | 33 | 111086 | 896 | 64386717 |
Large intestine perforation | 68.43 | 12.76 | 96 | 111023 | 12508 | 64375105 |
Osteosarcoma | 68.17 | 12.76 | 24 | 111095 | 282 | 64387331 |
Aplasia | 67.34 | 12.76 | 71 | 111048 | 6882 | 64380731 |
Wrong technique in product usage process | 66.83 | 12.76 | 15 | 111104 | 64959 | 64322654 |
Radiation oesophagitis | 66.75 | 12.76 | 28 | 111091 | 543 | 64387070 |
Bicytopenia | 66.63 | 12.76 | 53 | 111066 | 3569 | 64384044 |
Thrombotic microangiopathy | 66.54 | 12.76 | 110 | 111009 | 16545 | 64371068 |
Injury | 66.15 | 12.76 | 9 | 111110 | 55983 | 64331630 |
Hepatitis B | 66.13 | 12.76 | 74 | 111045 | 7671 | 64379942 |
Blood creatinine increased | 65.88 | 12.76 | 430 | 110689 | 135352 | 64252261 |
Cytomegalovirus oesophagitis | 64.97 | 12.76 | 28 | 111091 | 582 | 64387031 |
Loss of personal independence in daily activities | 64.68 | 12.76 | 22 | 111097 | 72432 | 64315181 |
Chloroma | 64.23 | 12.76 | 29 | 111090 | 676 | 64386937 |
Hypophosphataemia | 63.96 | 12.76 | 101 | 111018 | 14619 | 64372994 |
Inappropriate schedule of product administration | 63.86 | 12.76 | 40 | 111079 | 92246 | 64295367 |
Neutropenic colitis | 63.60 | 12.76 | 57 | 111062 | 4524 | 64383089 |
Bacterial translocation | 63.55 | 12.76 | 25 | 111094 | 408 | 64387205 |
Pleural effusion | 63.36 | 12.76 | 404 | 110715 | 126155 | 64261458 |
Influenza | 62.33 | 12.76 | 55 | 111064 | 106476 | 64281137 |
Influenza like illness | 61.97 | 12.76 | 15 | 111104 | 61687 | 64325926 |
Atypical haemolytic uraemic syndrome | 61.58 | 12.76 | 28 | 111091 | 664 | 64386949 |
Portal venous gas | 61.23 | 12.76 | 23 | 111096 | 329 | 64387284 |
Colitis | 60.25 | 12.76 | 230 | 110889 | 58444 | 64329169 |
Electrocardiogram QT prolonged | 59.89 | 12.76 | 31 | 111088 | 79417 | 64308196 |
Oesophageal stenosis | 59.86 | 12.76 | 51 | 111068 | 3783 | 64383830 |
Metastases to skin | 59.85 | 12.76 | 35 | 111084 | 1417 | 64386196 |
Discomfort | 58.86 | 12.76 | 33 | 111086 | 80845 | 64306768 |
Injection site swelling | 58.76 | 12.76 | 3 | 111116 | 41350 | 64346263 |
Bronchial fistula | 58.59 | 12.76 | 19 | 111100 | 170 | 64387443 |
Metastases to breast | 57.59 | 12.76 | 20 | 111099 | 225 | 64387388 |
Blood pressure fluctuation | 57.49 | 12.76 | 10 | 111109 | 51861 | 64335752 |
Infusion related reaction | 56.99 | 12.76 | 124 | 110995 | 164343 | 64223270 |
Renal tubular necrosis | 56.98 | 12.76 | 121 | 110998 | 21989 | 64365624 |
Radiation injury | 56.92 | 12.76 | 27 | 111092 | 707 | 64386906 |
Acquired gene mutation | 56.91 | 12.76 | 38 | 111081 | 1948 | 64385665 |
Deafness neurosensory | 56.31 | 12.76 | 62 | 111057 | 6312 | 64381301 |
Osteosarcoma metastatic | 55.78 | 12.76 | 14 | 111105 | 42 | 64387571 |
Oesophagobronchial fistula | 55.59 | 12.76 | 19 | 111100 | 203 | 64387410 |
Hypoglycaemia | 55.55 | 12.76 | 44 | 111075 | 89848 | 64297765 |
Vena cava thrombosis | 55.52 | 12.76 | 41 | 111078 | 2471 | 64385142 |
Pulmonary arteriopathy | 55.46 | 12.76 | 16 | 111103 | 92 | 64387521 |
Memory impairment | 55.44 | 12.76 | 40 | 111079 | 85642 | 64301971 |
Salivary gland cancer | 54.94 | 12.76 | 22 | 111097 | 377 | 64387236 |
Metastasis | 54.88 | 12.76 | 58 | 111061 | 5637 | 64381976 |
Exposure during pregnancy | 54.67 | 12.76 | 33 | 111086 | 77642 | 64309971 |
Embolism | 54.62 | 12.76 | 85 | 111034 | 12150 | 64375463 |
Disseminated intravascular coagulation | 53.30 | 12.76 | 149 | 110970 | 32199 | 64355414 |
Ameloblastoma | 53.09 | 12.76 | 15 | 111104 | 79 | 64387534 |
Renal infarct | 52.50 | 12.76 | 39 | 111080 | 2372 | 64385241 |
Cataract | 52.39 | 12.76 | 12 | 111107 | 51250 | 64336363 |
Vision blurred | 52.39 | 12.76 | 47 | 111072 | 90269 | 64297344 |
Heart rate decreased | 52.23 | 12.76 | 15 | 111104 | 55052 | 64332561 |
Tumour necrosis | 52.13 | 12.76 | 34 | 111085 | 1675 | 64385938 |
Empyema | 51.67 | 12.76 | 46 | 111073 | 3619 | 64383994 |
Anastomotic complication | 51.39 | 12.76 | 21 | 111098 | 380 | 64387233 |
Malaise | 50.56 | 12.76 | 438 | 110681 | 395809 | 63991804 |
Metastases to bone | 50.55 | 12.76 | 110 | 111009 | 20325 | 64367288 |
Tremor | 50.33 | 12.76 | 113 | 111006 | 148117 | 64239496 |
General physical health deterioration | 50.25 | 12.76 | 556 | 110563 | 203869 | 64183744 |
Splenic infarction | 50.18 | 12.76 | 43 | 111076 | 3214 | 64384399 |
Cardiomyopathy | 50.13 | 12.76 | 125 | 110994 | 25231 | 64362382 |
Serotonin syndrome | 49.67 | 12.76 | 5 | 111114 | 39277 | 64348336 |
Interstitial lung disease | 49.53 | 12.76 | 313 | 110806 | 97419 | 64290194 |
Fibromyalgia | 49.51 | 12.76 | 3 | 111116 | 35728 | 64351885 |
Osteoporosis | 49.15 | 12.76 | 7 | 111112 | 42073 | 64345540 |
Arteriospasm coronary | 48.01 | 12.76 | 53 | 111066 | 5412 | 64382201 |
Respiratory failure | 48.01 | 12.76 | 456 | 110663 | 160727 | 64226886 |
Pulmonary toxicity | 47.66 | 12.76 | 66 | 111053 | 8495 | 64379118 |
Tumour haemorrhage | 47.58 | 12.76 | 43 | 111076 | 3450 | 64384163 |
Lymphopenia | 47.11 | 12.76 | 123 | 110996 | 25534 | 64362079 |
Performance status decreased | 47.08 | 12.76 | 52 | 111067 | 5312 | 64382301 |
Gastrointestinal perforation | 46.61 | 12.76 | 52 | 111067 | 5372 | 64382241 |
Cerebral infarction | 46.41 | 12.76 | 166 | 110953 | 40878 | 64346735 |
Gastrooesophageal reflux disease | 46.18 | 12.76 | 45 | 111074 | 83098 | 64304515 |
Blood creatine phosphokinase increased | 45.41 | 12.76 | 22 | 111097 | 58536 | 64329077 |
Fluid retention | 45.31 | 12.76 | 23 | 111096 | 59583 | 64328030 |
Maternal exposure during pregnancy | 44.48 | 12.76 | 60 | 111059 | 95824 | 64291789 |
Mantle cell lymphoma recurrent | 44.15 | 12.76 | 20 | 111099 | 470 | 64387143 |
Radiation mucositis | 43.91 | 12.76 | 15 | 111104 | 160 | 64387453 |
Sedation | 43.81 | 12.76 | 9 | 111110 | 41453 | 64346160 |
Chronic obstructive pulmonary disease | 43.62 | 12.76 | 35 | 111084 | 71013 | 64316600 |
Fatigue | 43.61 | 12.76 | 971 | 110148 | 747759 | 63639854 |
Polyneuropathy | 43.54 | 12.76 | 102 | 111017 | 19792 | 64367821 |
Blood cholesterol increased | 43.32 | 12.76 | 16 | 111103 | 50050 | 64337563 |
Muscular weakness | 43.29 | 12.76 | 97 | 111022 | 127241 | 64260372 |
Aggression | 43.10 | 12.76 | 13 | 111106 | 46219 | 64341394 |
Blood sodium decreased | 42.99 | 12.76 | 130 | 110989 | 29352 | 64358261 |
Peritonitis | 42.95 | 12.76 | 117 | 111002 | 24906 | 64362707 |
Necrosis | 42.53 | 12.76 | 61 | 111058 | 8110 | 64379503 |
Blood stem cell transplant failure | 42.47 | 12.76 | 20 | 111099 | 515 | 64387098 |
B-cell lymphoma recurrent | 42.27 | 12.76 | 23 | 111096 | 809 | 64386804 |
Drug withdrawal syndrome | 42.25 | 12.76 | 3 | 111116 | 31288 | 64356325 |
Adverse drug reaction | 42.00 | 12.76 | 13 | 111106 | 45451 | 64342162 |
Type 2 diabetes mellitus | 41.32 | 12.76 | 5 | 111114 | 34015 | 64353598 |
Cerebral venous thrombosis | 41.27 | 12.76 | 34 | 111085 | 2407 | 64385206 |
Drug clearance decreased | 41.22 | 12.76 | 35 | 111084 | 2584 | 64385029 |
Palpitations | 41.18 | 12.76 | 73 | 111046 | 104415 | 64283198 |
Burning sensation | 41.11 | 12.76 | 17 | 111102 | 49647 | 64337966 |
Dermatitis acneiform | 41.00 | 12.76 | 61 | 111058 | 8382 | 64379231 |
Hallucination | 40.88 | 12.76 | 39 | 111080 | 72749 | 64314864 |
Cystitis haemorrhagic | 40.84 | 12.76 | 59 | 111060 | 7897 | 64379716 |
Coronary artery disease | 40.70 | 12.76 | 27 | 111092 | 60406 | 64327207 |
Tumour perforation | 40.70 | 12.76 | 17 | 111102 | 326 | 64387287 |
Intestinal ischaemia | 40.51 | 12.76 | 72 | 111047 | 11477 | 64376136 |
Hypoalbuminaemia | 40.19 | 12.76 | 92 | 111027 | 17582 | 64370031 |
Pneumatosis intestinalis | 39.66 | 12.76 | 47 | 111072 | 5182 | 64382431 |
Oedema peripheral | 39.56 | 12.76 | 207 | 110912 | 210110 | 64177503 |
Nervousness | 39.44 | 12.76 | 3 | 111116 | 29553 | 64358060 |
Red blood cell sedimentation rate increased | 39.43 | 12.76 | 4 | 111115 | 31231 | 64356382 |
Pneumothorax | 39.13 | 12.76 | 111 | 111008 | 24187 | 64363426 |
Cardiac disorder | 38.87 | 12.76 | 24 | 111095 | 55792 | 64331821 |
Hypoaesthesia | 38.83 | 12.76 | 117 | 111002 | 138991 | 64248622 |
Refeeding syndrome | 38.61 | 12.76 | 11 | 111108 | 60 | 64387553 |
Incorrect dose administered | 38.49 | 12.76 | 29 | 111090 | 60736 | 64326877 |
Hydronephrosis | 38.37 | 12.76 | 79 | 111040 | 14046 | 64373567 |
Back pain | 38.22 | 12.76 | 263 | 110856 | 249908 | 64137705 |
Adrenocortical carcinoma | 38.02 | 12.76 | 11 | 111108 | 64 | 64387549 |
Lactic acidosis | 38.01 | 12.76 | 30 | 111089 | 61380 | 64326233 |
Gastrointestinal anastomotic leak | 37.70 | 12.76 | 17 | 111102 | 395 | 64387218 |
Neoplasm recurrence | 37.68 | 12.76 | 39 | 111080 | 3700 | 64383913 |
Injection site reaction | 37.00 | 12.76 | 17 | 111102 | 46647 | 64340966 |
Confusional state | 36.77 | 12.76 | 281 | 110838 | 260863 | 64126750 |
Toxicity to various agents | 36.68 | 12.76 | 425 | 110694 | 363088 | 64024525 |
Unevaluable event | 36.16 | 12.76 | 21 | 111098 | 50468 | 64337145 |
Angioedema | 36.05 | 12.76 | 32 | 111087 | 61789 | 64325824 |
Sleep disorder | 35.92 | 12.76 | 30 | 111089 | 59679 | 64327934 |
Metastases to peritoneum | 35.75 | 12.76 | 37 | 111082 | 3510 | 64384103 |
Myasthenia gravis crisis | 35.63 | 12.76 | 21 | 111098 | 863 | 64386750 |
Gastrointestinal fungal infection | 35.48 | 12.76 | 16 | 111103 | 372 | 64387241 |
Osteosarcoma recurrent | 35.38 | 12.76 | 9 | 111110 | 29 | 64387584 |
Heart rate increased | 35.33 | 12.76 | 73 | 111046 | 98602 | 64289011 |
Peripheral sensory neuropathy | 34.96 | 12.76 | 67 | 111052 | 11311 | 64376302 |
Product prescribing error | 34.59 | 12.76 | 9 | 111110 | 35260 | 64352353 |
Fanconi syndrome | 34.49 | 12.76 | 31 | 111088 | 2470 | 64385143 |
Cholelithiasis | 33.93 | 12.76 | 18 | 111101 | 45488 | 64342125 |
Road traffic accident | 33.91 | 12.76 | 6 | 111113 | 30739 | 64356874 |
Blood pressure systolic increased | 33.43 | 12.76 | 22 | 111097 | 49431 | 64338182 |
Large intestinal ulcer perforation | 33.36 | 12.76 | 10 | 111109 | 67 | 64387546 |
Melanoderma | 33.25 | 12.76 | 15 | 111104 | 349 | 64387264 |
Neurosensory hypoacusis | 33.11 | 12.76 | 13 | 111106 | 211 | 64387402 |
Localised infection | 33.02 | 12.76 | 6 | 111113 | 30155 | 64357458 |
Small cell lung cancer | 32.84 | 12.76 | 31 | 111088 | 2630 | 64384983 |
Ureteric rupture | 32.72 | 12.76 | 7 | 111112 | 7 | 64387606 |
Coronary artery thrombosis | 32.72 | 12.76 | 32 | 111087 | 2837 | 64384776 |
Refractory cancer | 32.45 | 12.76 | 13 | 111106 | 223 | 64387390 |
Abortion spontaneous | 32.31 | 12.76 | 3 | 111116 | 25140 | 64362473 |
Mesenteric abscess | 32.14 | 12.76 | 11 | 111108 | 118 | 64387495 |
Extremity necrosis | 32.13 | 12.76 | 31 | 111088 | 2703 | 64384910 |
Haematoma | 32.05 | 12.76 | 20 | 111099 | 46230 | 64341383 |
Blindness cortical | 31.95 | 12.76 | 19 | 111100 | 794 | 64386819 |
Acoustic stimulation tests abnormal | 31.88 | 12.76 | 8 | 111111 | 24 | 64387589 |
Wernicke's encephalopathy | 31.88 | 12.76 | 8 | 111111 | 24 | 64387589 |
Cervix neoplasm | 31.55 | 12.76 | 12 | 111107 | 178 | 64387435 |
Malnutrition | 31.41 | 12.76 | 88 | 111031 | 19037 | 64368576 |
Irritability | 31.36 | 12.76 | 12 | 111107 | 36734 | 64350879 |
Metastases to meninges | 31.36 | 12.76 | 31 | 111088 | 2784 | 64384829 |
Plasma cell leukaemia | 31.33 | 12.76 | 24 | 111095 | 1529 | 64386084 |
Eye pain | 31.15 | 12.76 | 8 | 111111 | 31617 | 64355996 |
Ascites | 31.05 | 12.76 | 198 | 110921 | 61803 | 64325810 |
Injection site haemorrhage | 30.93 | 12.76 | 3 | 111116 | 24275 | 64363338 |
Throat irritation | 30.86 | 12.76 | 9 | 111110 | 32702 | 64354911 |
Blood glucose increased | 30.71 | 12.76 | 78 | 111041 | 97995 | 64289618 |
Cytopenia | 30.30 | 12.76 | 76 | 111043 | 15395 | 64372218 |
Dyskinesia | 30.23 | 12.76 | 15 | 111104 | 39373 | 64348240 |
Chemical peritonitis | 30.13 | 12.76 | 13 | 111106 | 271 | 64387342 |
Nasal abscess | 29.96 | 12.76 | 11 | 111108 | 147 | 64387466 |
Extravasation | 29.96 | 12.76 | 32 | 111087 | 3148 | 64384465 |
Flagellate dermatitis | 29.84 | 12.76 | 12 | 111107 | 208 | 64387405 |
Gait inability | 29.81 | 12.76 | 18 | 111101 | 42350 | 64345263 |
Cerebral ischaemia | 29.80 | 12.76 | 58 | 111061 | 9904 | 64377709 |
Myoclonus | 29.76 | 12.76 | 4 | 111115 | 25114 | 64362499 |
Plasmacytoma | 29.71 | 12.76 | 35 | 111084 | 3835 | 64383778 |
International normalised ratio increased | 29.69 | 12.76 | 57 | 111062 | 79110 | 64308503 |
Visceral venous thrombosis | 29.57 | 12.76 | 7 | 111112 | 15 | 64387598 |
Swelling face | 29.54 | 12.76 | 35 | 111084 | 59131 | 64328482 |
Nephritis bacterial | 29.53 | 12.76 | 8 | 111111 | 35 | 64387578 |
Gastric disorder | 29.51 | 12.76 | 7 | 111112 | 29190 | 64358423 |
Accidental exposure to product | 29.40 | 12.76 | 5 | 111114 | 26359 | 64361254 |
Product administration error | 29.20 | 12.76 | 6 | 111113 | 27637 | 64359976 |
Progressive multifocal leukoencephalopathy | 29.07 | 12.76 | 83 | 111036 | 18149 | 64369464 |
COVID-19 | 28.97 | 12.76 | 42 | 111077 | 65098 | 64322515 |
Emotional distress | 28.77 | 12.76 | 13 | 111106 | 36025 | 64351588 |
Blood lactate dehydrogenase increased | 28.64 | 12.76 | 123 | 110996 | 32955 | 64354658 |
Underdose | 28.58 | 12.76 | 5 | 111114 | 25824 | 64361789 |
Limb discomfort | 28.50 | 12.76 | 6 | 111113 | 27169 | 64360444 |
Musculoskeletal pain | 28.38 | 12.76 | 61 | 111058 | 81233 | 64306380 |
Basal cell carcinoma | 28.16 | 12.76 | 9 | 111110 | 30829 | 64356784 |
Hepatic candidiasis | 28.11 | 12.76 | 9 | 111110 | 77 | 64387536 |
Myocardial infarction | 28.02 | 12.76 | 169 | 110950 | 165652 | 64221961 |
Lymphadenopathy mediastinal | 28.02 | 12.76 | 34 | 111085 | 3842 | 64383771 |
Blood magnesium decreased | 27.96 | 12.76 | 69 | 111050 | 13836 | 64373777 |
Lip swelling | 27.94 | 12.76 | 10 | 111109 | 31897 | 64355716 |
Femur fracture | 27.75 | 12.76 | 12 | 111107 | 34123 | 64353490 |
Urinary tract infection | 27.73 | 12.76 | 260 | 110859 | 231336 | 64156277 |
Oesophageal perforation | 27.64 | 12.76 | 19 | 111100 | 1022 | 64386591 |
Metastases to adrenals | 27.62 | 12.76 | 20 | 111099 | 1169 | 64386444 |
Cerebral venous sinus thrombosis | 27.59 | 12.76 | 24 | 111095 | 1831 | 64385782 |
Joint stiffness | 27.54 | 12.76 | 9 | 111110 | 30395 | 64357218 |
Labelled drug-drug interaction medication error | 27.40 | 12.76 | 3 | 111116 | 22059 | 64365554 |
Swollen tongue | 27.30 | 12.76 | 13 | 111106 | 34941 | 64352672 |
Limb injury | 27.24 | 12.76 | 4 | 111115 | 23501 | 64364112 |
Agitation | 27.11 | 12.76 | 71 | 111048 | 88296 | 64299317 |
Poisoning | 27.11 | 12.76 | 3 | 111116 | 21876 | 64365737 |
Therapy cessation | 27.09 | 12.76 | 11 | 111108 | 32478 | 64355135 |
EGFR gene mutation | 27.04 | 12.76 | 13 | 111106 | 351 | 64387262 |
Pancreatitis | 26.93 | 12.76 | 38 | 111081 | 59569 | 64328044 |
Papillary thyroid cancer | 26.90 | 12.76 | 26 | 111093 | 2272 | 64385341 |
Failure to thrive | 26.88 | 12.76 | 57 | 111062 | 10347 | 64377266 |
Enterocolitis | 26.71 | 12.76 | 62 | 111057 | 11956 | 64375657 |
Hepatic steatosis | 26.67 | 12.76 | 10 | 111109 | 30997 | 64356616 |
Blood glucose decreased | 26.65 | 12.76 | 4 | 111115 | 23119 | 64364494 |
Cholangitis | 26.55 | 12.76 | 58 | 111061 | 10744 | 64376869 |
Right ventricular failure | 26.46 | 12.76 | 3 | 111116 | 21468 | 64366145 |
Testicular malignant teratoma | 26.33 | 12.76 | 6 | 111113 | 10 | 64387603 |
Tracheal stenosis | 26.26 | 12.76 | 12 | 111107 | 288 | 64387325 |
Nephrolithiasis | 26.21 | 12.76 | 22 | 111097 | 43661 | 64343952 |
Tumour thrombosis | 26.18 | 12.76 | 9 | 111110 | 98 | 64387515 |
Pericarditis | 26.17 | 12.76 | 42 | 111077 | 62474 | 64325139 |
Erythropenia | 26.03 | 12.76 | 13 | 111106 | 382 | 64387231 |
Device issue | 25.91 | 12.76 | 4 | 111115 | 22644 | 64364969 |
Impaired healing | 25.91 | 12.76 | 40 | 111079 | 60433 | 64327180 |
Blood HIV RNA increased | 25.78 | 12.76 | 21 | 111098 | 1463 | 64386150 |
Hyperhidrosis | 25.75 | 12.76 | 119 | 111000 | 124801 | 64262812 |
Diabetes mellitus | 25.68 | 12.76 | 47 | 111072 | 66427 | 64321186 |
Superior mesenteric artery syndrome | 25.66 | 12.76 | 10 | 111109 | 159 | 64387454 |
Dry eye | 25.57 | 12.76 | 9 | 111110 | 29010 | 64358603 |
Pregnancy | 25.50 | 12.76 | 3 | 111116 | 20862 | 64366751 |
Medulloblastoma recurrent | 25.47 | 12.76 | 9 | 111110 | 107 | 64387506 |
Lower respiratory tract infection | 25.39 | 12.76 | 81 | 111038 | 94533 | 64293080 |
Diaphragm muscle weakness | 25.37 | 12.76 | 10 | 111109 | 164 | 64387449 |
Tracheo-oesophageal fistula | 25.36 | 12.76 | 14 | 111105 | 507 | 64387106 |
Neutrophil count abnormal | 25.29 | 12.76 | 28 | 111091 | 2868 | 64384745 |
Traumatic lung injury | 25.24 | 12.76 | 25 | 111094 | 2251 | 64385362 |
Pain in jaw | 25.11 | 12.76 | 20 | 111099 | 40735 | 64346878 |
Ovarian vein thrombosis | 25.08 | 12.76 | 7 | 111112 | 35 | 64387578 |
Candida infection | 25.06 | 12.76 | 114 | 111005 | 31305 | 64356308 |
Sleep apnoea syndrome | 25.03 | 12.76 | 10 | 111109 | 29822 | 64357791 |
Liver function test abnormal | 24.78 | 12.76 | 40 | 111079 | 59361 | 64328252 |
Hypersensitivity | 24.62 | 12.76 | 218 | 110901 | 196234 | 64191379 |
Dysstasia | 24.60 | 12.76 | 5 | 111114 | 23210 | 64364403 |
Hip fracture | 24.58 | 12.76 | 8 | 111111 | 27091 | 64360522 |
Wound evisceration | 24.53 | 12.76 | 9 | 111110 | 120 | 64387493 |
Necrotising colitis | 24.52 | 12.76 | 17 | 111102 | 927 | 64386686 |
Death | 24.43 | 12.76 | 639 | 110480 | 482066 | 63905547 |
Product use issue | 24.40 | 12.76 | 157 | 110962 | 151558 | 64236055 |
Upper respiratory tract infection | 24.27 | 12.76 | 56 | 111063 | 72729 | 64314884 |
Haemoptysis | 24.17 | 12.76 | 156 | 110963 | 48892 | 64338721 |
Gout | 24.01 | 12.76 | 4 | 111115 | 21409 | 64366204 |
Accidental overdose | 23.97 | 12.76 | 14 | 111105 | 33543 | 64354070 |
Duodenal ulcer perforation | 23.95 | 12.76 | 15 | 111104 | 34610 | 64353003 |
Granulocyte-colony stimulating factor level increased | 23.90 | 12.76 | 5 | 111114 | 4 | 64387609 |
Melanosis | 23.87 | 12.76 | 7 | 111112 | 43 | 64387570 |
Rib fracture | 23.83 | 12.76 | 6 | 111113 | 24032 | 64363581 |
Intestinal perforation | 23.73 | 12.76 | 69 | 111050 | 15244 | 64372369 |
Hepatic cirrhosis | 23.44 | 12.76 | 8 | 111111 | 26290 | 64361323 |
Nightmare | 23.36 | 12.76 | 4 | 111115 | 20989 | 64366624 |
Myeloid leukaemia | 23.35 | 12.76 | 14 | 111105 | 594 | 64387019 |
Alpha 1 foetoprotein increased | 23.25 | 12.76 | 15 | 111104 | 725 | 64386888 |
Blood pressure diastolic decreased | 23.23 | 12.76 | 5 | 111114 | 22296 | 64365317 |
Sopor | 23.21 | 12.76 | 11 | 111108 | 29650 | 64357963 |
Chest discomfort | 23.11 | 12.76 | 112 | 111007 | 115994 | 64271619 |
Metastatic neoplasm | 22.88 | 12.76 | 33 | 111086 | 4409 | 64383204 |
Device related infection | 22.86 | 12.76 | 109 | 111010 | 30517 | 64357096 |
Stem cell transplant | 22.70 | 12.76 | 29 | 111090 | 3452 | 64384161 |
Obesity | 22.70 | 12.76 | 4 | 111115 | 20558 | 64367055 |
Herpes simplex encephalitis | 22.66 | 12.76 | 14 | 111105 | 627 | 64386986 |
Encephalopathy | 22.52 | 12.76 | 176 | 110943 | 58643 | 64328970 |
Multiple sclerosis | 22.48 | 12.76 | 3 | 111116 | 18938 | 64368675 |
Dyspnoea | 22.48 | 12.76 | 1011 | 110108 | 717663 | 63669950 |
Acne | 22.42 | 12.76 | 6 | 111113 | 23075 | 64364538 |
Fistula of small intestine | 22.38 | 12.76 | 14 | 111105 | 641 | 64386972 |
Haemophagocytic lymphohistiocytosis | 22.33 | 12.76 | 74 | 111045 | 17535 | 64370078 |
Purulent pericarditis | 22.28 | 12.76 | 7 | 111112 | 56 | 64387557 |
Sciatica | 22.25 | 12.76 | 4 | 111115 | 20260 | 64367353 |
Fanconi syndrome acquired | 22.17 | 12.76 | 24 | 111095 | 2397 | 64385216 |
Myelitis transverse | 22.15 | 12.76 | 20 | 111099 | 1603 | 64386010 |
Lymphangiosis carcinomatosa | 22.06 | 12.76 | 21 | 111098 | 1800 | 64385813 |
Crying | 21.98 | 12.76 | 4 | 111115 | 20086 | 64367527 |
Product quality issue | 21.90 | 12.76 | 12 | 111107 | 29787 | 64357826 |
Depressed mood | 21.85 | 12.76 | 23 | 111096 | 40989 | 64346624 |
Haemoglobin decreased | 21.82 | 12.76 | 464 | 110655 | 194599 | 64193014 |
Aortic embolus | 21.75 | 12.76 | 7 | 111112 | 61 | 64387552 |
Chromaturia | 21.74 | 12.76 | 6 | 111113 | 22605 | 64365008 |
Viral load increased | 21.64 | 12.76 | 24 | 111095 | 2463 | 64385150 |
Tooth disorder | 21.43 | 12.76 | 6 | 111113 | 22396 | 64365217 |
Gingivitis ulcerative | 21.40 | 12.76 | 10 | 111109 | 253 | 64387360 |
Abnormal behaviour | 21.35 | 12.76 | 16 | 111103 | 33606 | 64354007 |
Iliac artery occlusion | 21.15 | 12.76 | 10 | 111109 | 260 | 64387353 |
Angina pectoris | 21.11 | 12.76 | 28 | 111091 | 45053 | 64342560 |
Asthenia | 21.09 | 12.76 | 920 | 110199 | 427124 | 63960489 |
Ear infection | 21.07 | 12.76 | 7 | 111112 | 23397 | 64364216 |
Transitional cell carcinoma recurrent | 21.03 | 12.76 | 5 | 111114 | 11 | 64387602 |
Prescribed underdose | 21.03 | 12.76 | 3 | 111116 | 18012 | 64369601 |
Multiple organ dysfunction syndrome | 20.99 | 12.76 | 267 | 110852 | 101146 | 64286467 |
Movement disorder | 20.85 | 12.76 | 6 | 111113 | 21994 | 64365619 |
Acute promyelocytic leukaemia | 20.73 | 12.76 | 18 | 111101 | 1370 | 64386243 |
Cerebellar haemangioma | 20.72 | 12.76 | 7 | 111112 | 72 | 64387541 |
Iron deficiency anaemia | 20.69 | 12.76 | 6 | 111113 | 21883 | 64365730 |
Mucosal toxicity | 20.65 | 12.76 | 12 | 111107 | 480 | 64387133 |
Jaw operation | 20.50 | 12.76 | 14 | 111105 | 745 | 64386868 |
Hyperlipidaemia | 20.46 | 12.76 | 7 | 111112 | 22969 | 64364644 |
Metastases to abdominal cavity | 20.45 | 12.76 | 12 | 111107 | 489 | 64387124 |
Amputation stump pain | 20.44 | 12.76 | 6 | 111113 | 37 | 64387576 |
Carotid artery thrombosis | 20.43 | 12.76 | 20 | 111099 | 1775 | 64385838 |
Blood culture positive | 20.20 | 12.76 | 43 | 111076 | 7825 | 64379788 |
Varicella zoster virus infection | 20.20 | 12.76 | 29 | 111090 | 3859 | 64383754 |
Apparent mineralocorticoid excess | 20.17 | 12.76 | 6 | 111113 | 39 | 64387574 |
Transient ischaemic attack | 20.13 | 12.76 | 28 | 111091 | 44154 | 64343459 |
Enterocolitis infectious | 20.11 | 12.76 | 23 | 111096 | 2441 | 64385172 |
Rhinorrhoea | 20.11 | 12.76 | 46 | 111073 | 59923 | 64327690 |
Conductive deafness | 20.06 | 12.76 | 7 | 111112 | 80 | 64387533 |
Gastrointestinal necrosis | 19.98 | 12.76 | 33 | 111086 | 4959 | 64382654 |
Granulocyte count decreased | 19.97 | 12.76 | 17 | 111102 | 1259 | 64386354 |
Oral candidiasis | 19.85 | 12.76 | 86 | 111033 | 23126 | 64364487 |
Surgery | 19.83 | 12.76 | 12 | 111107 | 28201 | 64359412 |
Embryonal rhabdomyosarcoma | 19.79 | 12.76 | 6 | 111113 | 42 | 64387571 |
Azoospermia | 19.77 | 12.76 | 8 | 111111 | 141 | 64387472 |
Bradycardia | 19.69 | 12.76 | 121 | 110998 | 118098 | 64269515 |
Subclavian vein thrombosis | 19.57 | 12.76 | 22 | 111097 | 2292 | 64385321 |
Chemotherapy | 19.45 | 12.76 | 18 | 111101 | 1489 | 64386124 |
Pharyngeal stenosis | 19.45 | 12.76 | 5 | 111114 | 17 | 64387596 |
Hypersomnia | 19.39 | 12.76 | 5 | 111114 | 19712 | 64367901 |
Hallucination, auditory | 19.36 | 12.76 | 3 | 111116 | 16936 | 64370677 |
Frequent bowel movements | 19.28 | 12.76 | 4 | 111115 | 18301 | 64369312 |
Renal tubular injury | 19.27 | 12.76 | 16 | 111103 | 1145 | 64386468 |
Neoplasm malignant | 19.26 | 12.76 | 89 | 111030 | 24599 | 64363014 |
Abdominal pain | 19.26 | 12.76 | 688 | 110431 | 311687 | 64075926 |
Small intestinal perforation | 19.25 | 12.76 | 23 | 111096 | 2557 | 64385056 |
Oroticaciduria | 19.23 | 12.76 | 4 | 111115 | 3 | 64387610 |
Oesophageal squamous cell carcinoma metastatic | 19.23 | 12.76 | 4 | 111115 | 3 | 64387610 |
Extrapyramidal disorder | 19.15 | 12.76 | 5 | 111114 | 19547 | 64368066 |
Hepatitis B reactivation | 19.14 | 12.76 | 32 | 111087 | 4857 | 64382756 |
Carotid artery dissection | 19.13 | 12.76 | 10 | 111109 | 324 | 64387289 |
Renal tubular dysfunction | 19.12 | 12.76 | 13 | 111106 | 687 | 64386926 |
Alveolar soft part sarcoma | 19.10 | 12.76 | 7 | 111112 | 93 | 64387520 |
Dropped head syndrome | 18.96 | 12.76 | 9 | 111110 | 236 | 64387377 |
Anti-Muellerian hormone level decreased | 18.84 | 12.76 | 7 | 111112 | 97 | 64387516 |
Sinus polyp | 18.82 | 12.76 | 11 | 111108 | 445 | 64387168 |
Thrombocytopenia neonatal | 18.82 | 12.76 | 5 | 111114 | 20 | 64387593 |
Ileus | 18.81 | 12.76 | 84 | 111035 | 22882 | 64364731 |
Retinal ischaemia | 18.79 | 12.76 | 13 | 111106 | 707 | 64386906 |
Trigeminal nerve paresis | 18.70 | 12.76 | 4 | 111115 | 4 | 64387609 |
Maternal death affecting foetus | 18.70 | 12.76 | 4 | 111115 | 4 | 64387609 |
Chemotherapeutic drug level increased | 18.63 | 12.76 | 10 | 111109 | 342 | 64387271 |
Liver abscess | 18.62 | 12.76 | 33 | 111086 | 5247 | 64382366 |
Haemoperitoneum | 18.60 | 12.76 | 28 | 111091 | 3887 | 64383726 |
Cystitis | 18.50 | 12.76 | 28 | 111091 | 42647 | 64344966 |
Ureteric dilatation | 18.49 | 12.76 | 8 | 111111 | 168 | 64387445 |
Agranulocytosis | 18.47 | 12.76 | 121 | 110998 | 38108 | 64349505 |
Subcutaneous emphysema | 18.45 | 12.76 | 18 | 111101 | 1591 | 64386022 |
Prescribed overdose | 18.44 | 12.76 | 6 | 111113 | 20325 | 64367288 |
Herpes zoster | 18.43 | 12.76 | 72 | 111047 | 79115 | 64308498 |
Testicular cancer metastatic | 18.28 | 12.76 | 6 | 111113 | 56 | 64387557 |
Unresponsive to stimuli | 18.27 | 12.76 | 37 | 111082 | 50356 | 64337257 |
Axillary vein thrombosis | 18.19 | 12.76 | 12 | 111107 | 603 | 64387010 |
Dystonia | 18.15 | 12.76 | 5 | 111114 | 18860 | 64368753 |
Pneumonia | 18.12 | 12.76 | 1156 | 109963 | 558420 | 63829193 |
Metastases to pleura | 18.09 | 12.76 | 16 | 111103 | 1248 | 64386365 |
Clostridium colitis | 18.01 | 12.76 | 22 | 111097 | 2503 | 64385110 |
Testicular germ cell cancer metastatic | 18.00 | 12.76 | 6 | 111113 | 59 | 64387554 |
Choriocarcinoma | 17.91 | 12.76 | 6 | 111113 | 60 | 64387553 |
Amnesia | 17.88 | 12.76 | 35 | 111084 | 48234 | 64339379 |
Pharyngeal inflammation | 17.83 | 12.76 | 14 | 111105 | 925 | 64386688 |
Cervix carcinoma recurrent | 17.81 | 12.76 | 4 | 111115 | 6 | 64387607 |
Disturbance in attention | 17.76 | 12.76 | 27 | 111092 | 41047 | 64346566 |
Sweat gland tumour | 17.70 | 12.76 | 11 | 111108 | 498 | 64387115 |
Osteomyelitis | 17.68 | 12.76 | 13 | 111106 | 27574 | 64360039 |
Bone marrow disorder | 17.59 | 12.76 | 23 | 111096 | 2802 | 64384811 |
Gastroenteritis viral | 17.59 | 12.76 | 6 | 111113 | 19723 | 64367890 |
Mental disorder | 17.56 | 12.76 | 12 | 111107 | 26433 | 64361180 |
Clostridium bacteraemia | 17.52 | 12.76 | 9 | 111110 | 281 | 64387332 |
Acute myelomonocytic leukaemia | 17.52 | 12.76 | 9 | 111110 | 281 | 64387332 |
Lymphadenopathy | 17.49 | 12.76 | 139 | 110980 | 46547 | 64341066 |
Metastases to abdominal wall | 17.48 | 12.76 | 7 | 111112 | 120 | 64387493 |
Gastrointestinal ischaemia | 17.46 | 12.76 | 10 | 111109 | 389 | 64387224 |
Heart rate irregular | 17.46 | 12.76 | 13 | 111106 | 27400 | 64360213 |
Recurrent cancer | 17.45 | 12.76 | 21 | 111098 | 2352 | 64385261 |
Staphylococcal infection | 17.43 | 12.76 | 148 | 110971 | 50530 | 64337083 |
Portal vein thrombosis | 17.36 | 12.76 | 31 | 111088 | 4960 | 64382653 |
Retinopathy | 17.34 | 12.76 | 25 | 111094 | 3340 | 64384273 |
Campylobacter test positive | 17.32 | 12.76 | 6 | 111113 | 67 | 64387546 |
Morphoea | 17.30 | 12.76 | 10 | 111109 | 396 | 64387217 |
Night sweats | 17.28 | 12.76 | 22 | 111097 | 36024 | 64351589 |
Sarcomatoid carcinoma | 17.15 | 12.76 | 5 | 111114 | 30 | 64387583 |
Immune-mediated hepatic disorder | 17.10 | 12.76 | 11 | 111108 | 529 | 64387084 |
Breast cancer | 17.10 | 12.76 | 15 | 111104 | 29133 | 64358480 |
Thrombophlebitis migrans | 17.09 | 12.76 | 9 | 111110 | 296 | 64387317 |
Medication error | 17.02 | 12.76 | 38 | 111081 | 49928 | 64337685 |
Median nerve injury | 17.01 | 12.76 | 5 | 111114 | 31 | 64387582 |
Neck pain | 16.98 | 12.76 | 52 | 111067 | 61481 | 64326132 |
Hypovolaemia | 16.97 | 12.76 | 62 | 111057 | 15424 | 64372189 |
Laryngeal pain | 16.95 | 12.76 | 33 | 111086 | 5635 | 64381978 |
Vertigo | 16.91 | 12.76 | 49 | 111070 | 58962 | 64328651 |
Delusion | 16.91 | 12.76 | 5 | 111114 | 18009 | 64369604 |
Primitive neuroectodermal tumour | 16.88 | 12.76 | 5 | 111114 | 32 | 64387581 |
Muscle spasticity | 16.84 | 12.76 | 4 | 111115 | 16665 | 64370948 |
Jugular vein occlusion | 16.76 | 12.76 | 4 | 111115 | 9 | 64387604 |
Respiratory arrest | 16.69 | 12.76 | 42 | 111077 | 52943 | 64334670 |
Eczema | 16.60 | 12.76 | 16 | 111103 | 29704 | 64357909 |
Embolism venous | 16.55 | 12.76 | 25 | 111094 | 3482 | 64384131 |
Venous thrombosis | 16.53 | 12.76 | 35 | 111084 | 6346 | 64381267 |
Poor quality sleep | 16.49 | 12.76 | 6 | 111113 | 18945 | 64368668 |
Vascular injury | 16.47 | 12.76 | 14 | 111105 | 1035 | 64386578 |
Staphylococcal bacteraemia | 16.37 | 12.76 | 47 | 111072 | 10308 | 64377305 |
Glaucoma | 16.36 | 12.76 | 4 | 111115 | 16344 | 64371269 |
Device malfunction | 16.36 | 12.76 | 5 | 111114 | 17628 | 64369985 |
Ganglioneuroma | 16.31 | 12.76 | 7 | 111112 | 144 | 64387469 |
Embolism arterial | 16.27 | 12.76 | 15 | 111104 | 1235 | 64386378 |
Gene mutation | 16.26 | 12.76 | 19 | 111100 | 2063 | 64385550 |
Organising pneumonia | 16.20 | 12.76 | 43 | 111076 | 9012 | 64378601 |
Oesophageal squamous cell carcinoma recurrent | 16.10 | 12.76 | 3 | 111116 | 0 | 64387613 |
Mixed deafness | 16.10 | 12.76 | 3 | 111116 | 0 | 64387613 |
Emphysematous cholecystitis | 16.10 | 12.76 | 3 | 111116 | 0 | 64387613 |
Sepsis pasteurella | 16.10 | 12.76 | 3 | 111116 | 0 | 64387613 |
Gastrointestinal haemorrhage | 16.06 | 12.76 | 148 | 110971 | 132164 | 64255449 |
Delirium | 16.05 | 12.76 | 63 | 111056 | 69131 | 64318482 |
Leukaemic lymphoma | 16.03 | 12.76 | 6 | 111113 | 85 | 64387528 |
Paraneoplastic dermatomyositis | 16.02 | 12.76 | 5 | 111114 | 39 | 64387574 |
Toxic leukoencephalopathy | 16.01 | 12.76 | 13 | 111106 | 902 | 64386711 |
Oesophageal squamous cell carcinoma | 15.97 | 12.76 | 10 | 111109 | 459 | 64387154 |
Ischaemic stroke | 15.97 | 12.76 | 95 | 111024 | 28940 | 64358673 |
Ovarian cancer recurrent | 15.96 | 12.76 | 9 | 111110 | 340 | 64387273 |
Metapneumovirus bronchiolitis | 15.94 | 12.76 | 4 | 111115 | 12 | 64387601 |
Marchiafava-Bignami disease | 15.94 | 12.76 | 4 | 111115 | 12 | 64387601 |
Hot flush | 15.88 | 12.76 | 35 | 111084 | 46200 | 64341413 |
Staphylococcus test positive | 15.84 | 12.76 | 32 | 111087 | 5613 | 64382000 |
Liver function test increased | 15.80 | 12.76 | 18 | 111101 | 30952 | 64356661 |
Dementia | 15.80 | 12.76 | 8 | 111111 | 20758 | 64366855 |
Meningitis tuberculous | 15.77 | 12.76 | 14 | 111105 | 1097 | 64386516 |
Lung cancer metastatic | 15.70 | 12.76 | 23 | 111096 | 3117 | 64384496 |
Laryngeal cancer stage IV | 15.70 | 12.76 | 4 | 111115 | 13 | 64387600 |
Eye irritation | 15.63 | 12.76 | 4 | 111115 | 15852 | 64371761 |
Restless legs syndrome | 15.62 | 12.76 | 5 | 111114 | 17111 | 64370502 |
Abdominal pain upper | 15.60 | 12.76 | 210 | 110909 | 174820 | 64212793 |
Proctitis | 15.59 | 12.76 | 23 | 111096 | 3136 | 64384477 |
Rash pruritic | 15.50 | 12.76 | 49 | 111070 | 57355 | 64330258 |
Retinal toxicity | 15.48 | 12.76 | 15 | 111104 | 1315 | 64386298 |
Cytokine release syndrome | 15.45 | 12.76 | 74 | 111045 | 20755 | 64366858 |
Metastases to retroperitoneum | 15.40 | 12.76 | 9 | 111110 | 364 | 64387249 |
Skin ulcer | 15.34 | 12.76 | 33 | 111086 | 43941 | 64343672 |
Myasthenic syndrome | 15.33 | 12.76 | 11 | 111108 | 634 | 64386979 |
Pericardial effusion | 15.33 | 12.76 | 118 | 111001 | 39136 | 64348477 |
Dyspnoea exertional | 15.33 | 12.76 | 70 | 111049 | 73660 | 64313953 |
Sinus disorder | 15.32 | 12.76 | 5 | 111114 | 16903 | 64370710 |
Pelvic fluid collection | 15.28 | 12.76 | 11 | 111108 | 637 | 64386976 |
Uterine atrophy | 15.26 | 12.76 | 4 | 111115 | 15 | 64387598 |
BRAF gene mutation | 15.20 | 12.76 | 5 | 111114 | 47 | 64387566 |
Cell-mediated immune deficiency | 15.19 | 12.76 | 6 | 111113 | 99 | 64387514 |
Necrosis ischaemic | 15.19 | 12.76 | 13 | 111106 | 970 | 64386643 |
Granulocytopenia | 15.19 | 12.76 | 46 | 111073 | 10394 | 64377219 |
Fistula | 15.14 | 12.76 | 44 | 111075 | 9717 | 64377896 |
Metastases to thorax | 15.09 | 12.76 | 7 | 111112 | 174 | 64387439 |
Vascular compression | 15.06 | 12.76 | 8 | 111111 | 268 | 64387345 |
Noctiphobia | 15.05 | 12.76 | 4 | 111115 | 16 | 64387597 |
Myositis | 15.03 | 12.76 | 62 | 111057 | 16315 | 64371298 |
Sinus congestion | 15.02 | 12.76 | 4 | 111115 | 15435 | 64372178 |
Cellulitis | 15.01 | 12.76 | 97 | 111022 | 93560 | 64294053 |
Hypoxia | 14.95 | 12.76 | 224 | 110895 | 87925 | 64299688 |
Muscle twitching | 14.94 | 12.76 | 7 | 111112 | 18991 | 64368622 |
Kidney infection | 14.93 | 12.76 | 6 | 111113 | 17832 | 64369781 |
Thrombocytosis | 14.91 | 12.76 | 36 | 111083 | 7120 | 64380493 |
Procedural vomiting | 14.90 | 12.76 | 11 | 111108 | 663 | 64386950 |
Endothelial dysfunction | 14.84 | 12.76 | 7 | 111112 | 181 | 64387432 |
Blood loss anaemia | 14.71 | 12.76 | 3 | 111116 | 13889 | 64373724 |
Renal-limited thrombotic microangiopathy | 14.67 | 12.76 | 4 | 111115 | 18 | 64387595 |
Hypoglossal nerve paresis | 14.66 | 12.76 | 6 | 111113 | 109 | 64387504 |
Eosinophilia | 14.64 | 12.76 | 27 | 111092 | 38049 | 64349564 |
Fracture | 14.61 | 12.76 | 7 | 111112 | 18748 | 64368865 |
Ovarian failure | 14.60 | 12.76 | 10 | 111109 | 535 | 64387078 |
Diabetic ketoacidosis | 14.53 | 12.76 | 18 | 111101 | 29827 | 64357786 |
Cerebral salt-wasting syndrome | 14.51 | 12.76 | 6 | 111113 | 112 | 64387501 |
Dysphonia | 14.43 | 12.76 | 37 | 111082 | 46345 | 64341268 |
Synovial sarcoma | 14.34 | 12.76 | 5 | 111114 | 57 | 64387556 |
Depressed level of consciousness | 14.28 | 12.76 | 82 | 111037 | 81354 | 64306259 |
Thymus enlargement | 14.27 | 12.76 | 6 | 111113 | 117 | 64387496 |
Anaplastic lymphoma kinase gene mutation | 14.23 | 12.76 | 6 | 111113 | 118 | 64387495 |
Upper limb fracture | 14.19 | 12.76 | 4 | 111115 | 14862 | 64372751 |
Hernia | 14.14 | 12.76 | 3 | 111116 | 13515 | 64374098 |
Pericardial fibrosis | 14.03 | 12.76 | 5 | 111114 | 61 | 64387552 |
Carotid artery perforation | 14.02 | 12.76 | 3 | 111116 | 3 | 64387610 |
Full blood count decreased | 14.01 | 12.76 | 11 | 111108 | 22571 | 64365042 |
Mood altered | 14.00 | 12.76 | 5 | 111114 | 15974 | 64371639 |
Intestinal infarction | 13.98 | 12.76 | 14 | 111105 | 1277 | 64386336 |
Hyperglycaemic hyperosmolar nonketotic syndrome | 13.95 | 12.76 | 16 | 111103 | 1703 | 64385910 |
Hyperammonaemic encephalopathy | 13.85 | 12.76 | 25 | 111094 | 4033 | 64383580 |
Skin exfoliation | 13.81 | 12.76 | 36 | 111083 | 44849 | 64342764 |
Haematochezia | 13.81 | 12.76 | 63 | 111056 | 66310 | 64321303 |
Malignant pleural effusion | 13.79 | 12.76 | 21 | 111098 | 2946 | 64384667 |
Stent malfunction | 13.74 | 12.76 | 5 | 111114 | 65 | 64387548 |
Diabetes mellitus inadequate control | 13.73 | 12.76 | 10 | 111109 | 21311 | 64366302 |
Fear | 13.60 | 12.76 | 9 | 111110 | 20162 | 64367451 |
Enterococcal sepsis | 13.54 | 12.76 | 19 | 111100 | 2475 | 64385138 |
Skin toxicity | 13.53 | 12.76 | 33 | 111086 | 6569 | 64381044 |
Obstructive airways disorder | 13.52 | 12.76 | 12 | 111107 | 23173 | 64364440 |
Retroperitoneal lymphadenopathy | 13.50 | 12.76 | 12 | 111107 | 942 | 64386671 |
Thrombophlebitis | 13.49 | 12.76 | 30 | 111089 | 5624 | 64381989 |
Enterococcal bacteraemia | 13.48 | 12.76 | 19 | 111100 | 2486 | 64385127 |
Metastases to bladder | 13.47 | 12.76 | 7 | 111112 | 224 | 64387389 |
VIth nerve paresis | 13.44 | 12.76 | 6 | 111113 | 136 | 64387477 |
Culture urine positive | 13.44 | 12.76 | 25 | 111094 | 4126 | 64383487 |
Thrombotic thrombocytopenic purpura | 13.44 | 12.76 | 31 | 111088 | 5953 | 64381660 |
Coma | 13.41 | 12.76 | 92 | 111027 | 87523 | 64300090 |
Procedural pain | 13.34 | 12.76 | 5 | 111114 | 15503 | 64372110 |
Retroperitoneal neoplasm | 13.32 | 12.76 | 4 | 111115 | 27 | 64387586 |
Body temperature decreased | 13.31 | 12.76 | 15 | 111104 | 25913 | 64361700 |
Oral fungal infection | 13.29 | 12.76 | 21 | 111098 | 3040 | 64384573 |
Epiphyses premature fusion | 13.28 | 12.76 | 5 | 111114 | 72 | 64387541 |
Adenocarcinoma gastric | 13.21 | 12.76 | 15 | 111104 | 1580 | 64386033 |
Hypothermia | 13.19 | 12.76 | 9 | 111110 | 19847 | 64367766 |
Malignant peritoneal neoplasm | 13.17 | 12.76 | 10 | 111109 | 629 | 64386984 |
Mydriasis | 13.07 | 12.76 | 5 | 111114 | 15307 | 64372306 |
Gastroenteritis sapovirus | 13.05 | 12.76 | 6 | 111113 | 146 | 64387467 |
Blood chloride decreased | 13.05 | 12.76 | 35 | 111084 | 7381 | 64380232 |
Blastic plasmacytoid dendritic cell neoplasia | 12.97 | 12.76 | 5 | 111114 | 77 | 64387536 |
Ecchymosis | 12.97 | 12.76 | 4 | 111115 | 14018 | 64373595 |
Pulmonary artery thrombosis | 12.92 | 12.76 | 13 | 111106 | 1193 | 64386420 |
Paranoia | 12.89 | 12.76 | 6 | 111113 | 16346 | 64371267 |
Eye pruritus | 12.86 | 12.76 | 3 | 111116 | 12656 | 64374957 |
Peritoneal sarcoma | 12.81 | 12.76 | 3 | 111116 | 6 | 64387607 |
Stoma site dermatitis | 12.81 | 12.76 | 3 | 111116 | 6 | 64387607 |
Mania | 12.81 | 12.76 | 6 | 111113 | 16280 | 64371333 |
None
Source | Code | Description |
---|---|---|
ATC | L01XA01 | ANTINEOPLASTIC AND IMMUNOMODULATING AGENTS ANTINEOPLASTIC AGENTS OTHER ANTINEOPLASTIC AGENTS Platinum compounds |
FDA EXT | N0000175073 | Platinum-containing Compounds |
FDA EPC | N0000175413 | Platinum-based Drug |
MeSH PA | D000970 | Antineoplastic Agents |
MeSH PA | D003432 | Cross-Linking Reagents |
MeSH PA | D007202 | Indicators and Reagents |
MeSH PA | D011838 | Radiation-Sensitizing Agents |
CHEBI has role | CHEBI:25435 | mutagens |
CHEBI has role | CHEBI:35610 | antineoplastic agents |
CHEBI has role | CHEBI:47868 | photosensitising agent |
CHEBI has role | CHEBI:50684 | cross-linking reagents |
CHEBI has role | CHEBI:50902 | genotoxic agent |
CHEBI has role | CHEBI:61015 | nephrotoxins |
CHEBI has role | CHEBI:68495 | Type I cell-death inducers |
CHEBI has role | CHEBI:173085 | ferroptosis inducers |
Disease | Relation | SNOMED_ID | DOID |
---|---|---|---|
Malignant tumor of ovary | indication | 363443007 | DOID:2394 |
Ovarian Germ Cell Tumor Carcinoma | indication | ||
Testicular Germ Cell Tumor | indication | ||
Invasive Bladder Malignancy | indication |
None
None
None
None
None
Target | Class | Pharos | UniProt | Action | Type | Activity value (-log[M]) | Mechanism action | Bioact source | MoA source |
---|---|---|---|---|---|---|---|---|---|
D(3) dopamine receptor | GPCR | Ki | 5.95 | CHEMBL | |||||
Muscarinic acetylcholine receptor M5 | GPCR | Ki | 5.37 | CHEMBL | |||||
Canalicular multispecific organic anion transporter 1 | Transporter | WOMBAT-PK | |||||||
Adenosine receptor A3 | GPCR | Ki | 5.62 | DRUG MATRIX | |||||
Multidrug resistance-associated protein 6 | Transporter | WOMBAT-PK | |||||||
Multidrug resistance-associated protein 5 | Transporter | WOMBAT-PK | |||||||
Epidermal growth factor receptor | Kinase | IC50 | 5.58 | DRUG MATRIX | |||||
Tyrosine-protein kinase Lck | Kinase | IC50 | 4.64 | DRUG MATRIX | |||||
Tyrosine-protein kinase Fyn | Kinase | IC50 | 5.32 | DRUG MATRIX | |||||
C-X-C chemokine receptor type 2 | GPCR | Ki | 5.02 | DRUG MATRIX | |||||
Thromboxane-A synthase | Enzyme | IC50 | 5.03 | DRUG MATRIX | |||||
C-C chemokine receptor type 2 | GPCR | Ki | 5.15 | DRUG MATRIX | |||||
Mitogen-activated protein kinase 3 | Kinase | IC50 | 5.34 | DRUG MATRIX | |||||
Melanocortin receptor 5 | GPCR | Ki | 5.22 | DRUG MATRIX | |||||
Sodium/potassium-transporting ATPase subunit alpha-2 | Ion channel | IC50 | 5.03 | DRUG MATRIX |
ID | Source |
---|---|
D00275 | KEGG_DRUG |
4018139 | VUID |
N0000146476 | NUI |
4018139 | VANDF |
C0008838 | UMLSCUI |
CHEBI:27899 | CHEBI |
CPT | PDB_CHEM_ID |
CHEMBL1386 | ChEMBL_ID |
CHEMBL11359 | ChEMBL_ID |
CHEMBL2068237 | ChEMBL_ID |
DB00515 | DRUGBANK_ID |
5343 | IUPHAR_LIGAND_ID |
4426 | INN_ID |
Q20Q21Q62J | UNII |
5702198 | PUBCHEM_CID |
2555 | RXNORM |
31747 | MMSL |
4456 | MMSL |
d00195 | MMSL |
002641 | NDDF |
387318005 | SNOMEDCT_US |
57066004 | SNOMEDCT_US |
D002945 | MESH_DESCRIPTOR_UI |
Product | Category | Ingredients | NDC | Form | Quantity | Route | Marketing | Label |
---|---|---|---|---|---|---|---|---|
CISplatin | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0143-9504 | INJECTION | 1 mg | INTRAVENOUS | ANDA | 19 sections |
CISplatin | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0143-9505 | INJECTION | 1 mg | INTRAVENOUS | ANDA | 19 sections |
Cisplatin | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0703-5747 | INJECTION, SOLUTION | 50 mg | INTRAVENOUS | ANDA | 21 sections |
Cisplatin | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0703-5748 | INJECTION, SOLUTION | 100 mg | INTRAVENOUS | ANDA | 21 sections |
Cisplatin | HUMAN PRESCRIPTION DRUG LABEL | 1 | 16729-288 | INJECTION | 1 mg | INTRAVENOUS | ANDA | 26 sections |
CISplatin | HUMAN PRESCRIPTION DRUG LABEL | 1 | 44567-509 | INJECTION, SOLUTION | 1 mg | INTRAVENOUS | NDA | 19 sections |
CISplatin | HUMAN PRESCRIPTION DRUG LABEL | 1 | 44567-510 | INJECTION, SOLUTION | 1 mg | INTRAVENOUS | NDA | 19 sections |
CISplatin | HUMAN PRESCRIPTION DRUG LABEL | 1 | 44567-511 | INJECTION, SOLUTION | 1 mg | INTRAVENOUS | NDA | 19 sections |
Cisplatin | HUMAN PRESCRIPTION DRUG LABEL | 1 | 44567-530 | INJECTION, POWDER, LYOPHILIZED, FOR SOLUTION | 1 mg | INTRAVENOUS | NDA | 26 sections |
Cisplatin | HUMAN PRESCRIPTION DRUG LABEL | 1 | 63323-103 | INJECTION, SOLUTION | 1 mg | INTRAVENOUS | ANDA | 13 sections |
Cisplatin | HUMAN PRESCRIPTION DRUG LABEL | 1 | 68001-283 | INJECTION | 1 mg | INTRAVENOUS | ANDA | 26 sections |
CISPLATIN | Human Prescription Drug Label | 1 | 68083-162 | INJECTION, SOLUTION | 1 mg | INTRAVENOUS | ANDA | 13 sections |
CISPLATIN | Human Prescription Drug Label | 1 | 68083-163 | INJECTION, SOLUTION | 1 mg | INTRAVENOUS | ANDA | 13 sections |
Cisplatin | HUMAN PRESCRIPTION DRUG LABEL | 1 | 70860-206 | INJECTION, SOLUTION | 1 mg | INTRAVENOUS | ANDA | 21 sections |