Stem definition | Drug id | CAS RN |
---|---|---|
antineoplastic agents, platinum derivatives | 4392 | 15663-27-1 |
Molecule | Description |
---|---|
Synonyms:
|
An inorganic and water-soluble platinum complex. After undergoing hydrolysis, it reacts with DNA to produce both intra and interstrand crosslinks. These crosslinks appear to impair replication and transcription of DNA. The cytotoxicity of cisplatin correlates with cellular arrest in the G2 phase of the cell cycle.
|
None
Property | Value | Reference |
---|---|---|
BDDCS (Biopharmaceutical Drug Disposition Classification System) | 1 | Benet LZ, Broccatelli F, Oprea TI |
S (Water solubility) | 2.53 mg/mL | Benet LZ, Broccatelli F, Oprea TI |
EoM (Fraction excreted unchanged in urine) | 2.30 % | Benet LZ, Broccatelli F, Oprea TI |
MRTD (Maximum Recommended Therapeutic Daily Dose) | 4.75 ยตM/kg/day | Contrera JF, Matthews EJ, Kruhlak NL, Benz RD |
Date | Agency | Company | Orphan |
---|---|---|---|
Dec. 19, 1978 | FDA | HQ SPCLT PHARMA |
MedDRA adverse event term | Likelihood ratio | Likelihood ratio threshold | Patients taking drug having adverse event | Patients taking drug not having adverse event | Patients not taking drug having adverse event | Patients not taking drug not having adverse event |
---|---|---|---|---|---|---|
Febrile neutropenia | 1109.96 | 15.79 | 880 | 54501 | 104665 | 56132021 |
Neutropenia | 1031.91 | 15.79 | 1005 | 54376 | 157162 | 56079524 |
Thrombocytopenia | 753.00 | 15.79 | 792 | 54589 | 135432 | 56101254 |
Disease progression | 634.11 | 15.79 | 641 | 54740 | 104532 | 56132154 |
Malignant neoplasm progression | 593.39 | 15.79 | 527 | 54854 | 73060 | 56163626 |
Bone marrow failure | 497.48 | 15.79 | 323 | 55058 | 27963 | 56208723 |
Mucosal inflammation | 496.84 | 15.79 | 379 | 55002 | 42431 | 56194255 |
Haematotoxicity | 491.43 | 15.79 | 214 | 55167 | 8169 | 56228517 |
Anaemia | 422.35 | 15.79 | 858 | 54523 | 266653 | 55970033 |
Vomiting | 418.50 | 15.79 | 1253 | 54128 | 496975 | 55739711 |
Ototoxicity | 411.54 | 15.79 | 114 | 55267 | 1052 | 56235634 |
Pancytopenia | 360.18 | 15.79 | 440 | 54941 | 88275 | 56148411 |
Myelosuppression | 340.85 | 15.79 | 213 | 55168 | 17242 | 56219444 |
Nausea | 279.80 | 15.79 | 1481 | 53900 | 762697 | 55473989 |
Leukopenia | 272.00 | 15.79 | 342 | 55039 | 70598 | 56166088 |
Arthralgia | 269.54 | 15.79 | 80 | 55301 | 501589 | 55735097 |
Acute myeloid leukaemia | 267.31 | 15.79 | 181 | 55200 | 16791 | 56219895 |
Dehydration | 263.88 | 15.79 | 521 | 54860 | 158304 | 56078382 |
Posterior reversible encephalopathy syndrome | 246.10 | 15.79 | 168 | 55213 | 15792 | 56220894 |
Second primary malignancy | 240.62 | 15.79 | 126 | 55255 | 7276 | 56229410 |
Hypomagnesaemia | 229.36 | 15.79 | 193 | 55188 | 24822 | 56211864 |
Off label use | 223.08 | 15.79 | 1107 | 54274 | 555073 | 55681613 |
Joint swelling | 218.03 | 15.79 | 18 | 55363 | 289782 | 55946904 |
Neutrophil count decreased | 195.38 | 15.79 | 243 | 55138 | 49579 | 56187107 |
Hypokalaemia | 188.08 | 15.79 | 335 | 55046 | 94102 | 56142584 |
Renal salt-wasting syndrome | 181.80 | 15.79 | 46 | 55335 | 287 | 56236399 |
Pain | 178.04 | 15.79 | 236 | 55145 | 662948 | 55573738 |
Deafness | 171.62 | 15.79 | 137 | 55244 | 16357 | 56220329 |
Ovarian germ cell teratoma | 166.44 | 15.79 | 35 | 55346 | 78 | 56236608 |
Myelodysplastic syndrome | 165.88 | 15.79 | 134 | 55247 | 16272 | 56220414 |
Diffuse large B-cell lymphoma recurrent | 165.30 | 15.79 | 63 | 55318 | 1694 | 56234992 |
Abdominal discomfort | 162.37 | 15.79 | 37 | 55344 | 277237 | 55959449 |
Teratoma | 160.85 | 15.79 | 37 | 55344 | 143 | 56236543 |
Arthropathy | 160.58 | 15.79 | 9 | 55372 | 200266 | 56036420 |
Neutropenic sepsis | 153.47 | 15.79 | 124 | 55257 | 15061 | 56221625 |
Aortic thrombosis | 150.52 | 15.79 | 51 | 55330 | 966 | 56235720 |
Metastases to lung | 149.74 | 15.79 | 110 | 55271 | 11608 | 56225078 |
Neoplasm progression | 146.59 | 15.79 | 169 | 55212 | 31847 | 56204839 |
Peripheral swelling | 146.35 | 15.79 | 27 | 55354 | 234699 | 56001987 |
Platelet count decreased | 146.09 | 15.79 | 323 | 55058 | 106060 | 56130626 |
Product dose omission issue | 145.22 | 15.79 | 16 | 55365 | 204737 | 56031949 |
Nephropathy toxic | 144.02 | 15.79 | 95 | 55286 | 8432 | 56228254 |
Drug resistance | 143.62 | 15.79 | 136 | 55245 | 20406 | 56216280 |
Metastases to central nervous system | 141.87 | 15.79 | 108 | 55273 | 12028 | 56224658 |
Contraindicated product administered | 141.60 | 15.79 | 11 | 55370 | 186275 | 56050411 |
Gastrointestinal toxicity | 140.38 | 15.79 | 83 | 55298 | 6073 | 56230613 |
Fall | 138.31 | 15.79 | 91 | 55290 | 357419 | 55879267 |
Therapeutic product effect decreased | 134.64 | 15.79 | 8 | 55373 | 169444 | 56067242 |
Musculoskeletal stiffness | 131.56 | 15.79 | 5 | 55376 | 156002 | 56080684 |
Sepsis | 130.16 | 15.79 | 366 | 55015 | 139474 | 56097212 |
Diffuse large B-cell lymphoma refractory | 126.30 | 15.79 | 46 | 55335 | 1086 | 56235600 |
Swelling | 123.49 | 15.79 | 41 | 55340 | 239730 | 55996956 |
Acute kidney injury | 119.44 | 15.79 | 511 | 54870 | 240252 | 55996434 |
Pulmonary embolism | 118.52 | 15.79 | 299 | 55082 | 106825 | 56129861 |
Hyponatraemia | 116.05 | 15.79 | 288 | 55093 | 101851 | 56134835 |
Pyrexia | 112.33 | 15.79 | 750 | 54631 | 418023 | 55818663 |
Weight increased | 110.29 | 15.79 | 44 | 55337 | 229659 | 56007027 |
Urogenital fistula | 109.80 | 15.79 | 28 | 55353 | 181 | 56236505 |
Drug hypersensitivity | 107.79 | 15.79 | 69 | 55312 | 275136 | 55961550 |
Hypocalcaemia | 107.49 | 15.79 | 137 | 55244 | 28623 | 56208063 |
Neurotoxicity | 107.42 | 15.79 | 103 | 55278 | 15692 | 56220994 |
Cardiomyopathy | 104.90 | 15.79 | 103 | 55278 | 16155 | 56220531 |
Nasopharyngitis | 103.37 | 15.79 | 44 | 55337 | 220915 | 56015771 |
Cardiotoxicity | 100.43 | 15.79 | 73 | 55308 | 7577 | 56229109 |
Oesophagitis | 100.04 | 15.79 | 94 | 55287 | 13963 | 56222723 |
Pain in extremity | 96.87 | 15.79 | 90 | 55291 | 297341 | 55939345 |
Metastases to liver | 95.54 | 15.79 | 112 | 55269 | 21474 | 56215212 |
Wound | 95.52 | 15.79 | 12 | 55369 | 138792 | 56097894 |
Rash | 94.17 | 15.79 | 217 | 55164 | 492830 | 55743856 |
Pruritus | 93.80 | 15.79 | 104 | 55277 | 316519 | 55920167 |
Headache | 92.24 | 15.79 | 265 | 55116 | 558779 | 55677907 |
Product use in unapproved indication | 91.83 | 15.79 | 326 | 55055 | 140496 | 56096190 |
Tumour lysis syndrome | 91.48 | 15.79 | 70 | 55311 | 7853 | 56228833 |
Drug ineffective | 90.19 | 15.79 | 534 | 54847 | 918455 | 55318231 |
Metastases to lymph nodes | 88.84 | 15.79 | 67 | 55314 | 7356 | 56229330 |
Septic shock | 88.33 | 15.79 | 189 | 55192 | 60646 | 56176040 |
Hydronephrosis | 88.19 | 15.79 | 73 | 55308 | 9169 | 56227517 |
Therapy partial responder | 88.18 | 15.79 | 68 | 55313 | 7717 | 56228969 |
Renal failure | 87.33 | 15.79 | 273 | 55108 | 110227 | 56126459 |
Disease recurrence | 85.00 | 15.79 | 111 | 55270 | 23749 | 56212937 |
Arthritis | 84.85 | 15.79 | 3 | 55378 | 99849 | 56136837 |
Neuropathy peripheral | 84.83 | 15.79 | 258 | 55123 | 102635 | 56134051 |
Sinusitis | 82.29 | 15.79 | 46 | 55335 | 197535 | 56039151 |
White blood cell count decreased | 81.55 | 15.79 | 291 | 55090 | 125699 | 56110987 |
Hypophagia | 81.38 | 15.79 | 120 | 55261 | 28756 | 56207930 |
Asthma | 79.43 | 15.79 | 9 | 55372 | 112761 | 56123925 |
Insomnia | 79.42 | 15.79 | 45 | 55336 | 191815 | 56044871 |
Condition aggravated | 79.35 | 15.79 | 136 | 55245 | 344762 | 55891924 |
Contusion | 77.40 | 15.79 | 16 | 55365 | 128414 | 56108272 |
Pericarditis | 75.95 | 15.79 | 9 | 55372 | 108914 | 56127772 |
Injection site pain | 73.95 | 15.79 | 13 | 55368 | 117105 | 56119581 |
Tinnitus | 73.61 | 15.79 | 117 | 55264 | 29925 | 56206761 |
Drug intolerance | 73.02 | 15.79 | 92 | 55289 | 264726 | 55971960 |
Oesophageal fistula | 72.83 | 15.79 | 19 | 55362 | 136 | 56236550 |
Hepatic enzyme increased | 72.67 | 15.79 | 39 | 55342 | 171345 | 56065341 |
Blister | 71.17 | 15.79 | 11 | 55370 | 108876 | 56127810 |
Renal tubular disorder | 71.16 | 15.79 | 39 | 55342 | 2467 | 56234219 |
Teratoma benign | 70.57 | 15.79 | 16 | 55365 | 57 | 56236629 |
Ascites | 69.34 | 15.79 | 129 | 55252 | 37415 | 56199271 |
Febrile bone marrow aplasia | 69.23 | 15.79 | 55 | 55326 | 6517 | 56230169 |
Migraine | 69.21 | 15.79 | 4 | 55377 | 86793 | 56149893 |
Electrolyte imbalance | 67.53 | 15.79 | 86 | 55295 | 17947 | 56218739 |
Palmar-plantar erythrodysaesthesia syndrome | 67.39 | 15.79 | 93 | 55288 | 20972 | 56215714 |
Ovarian cancer recurrent | 66.85 | 15.79 | 29 | 55352 | 1095 | 56235591 |
Renal impairment | 64.29 | 15.79 | 200 | 55181 | 80513 | 56156173 |
Radiation skin injury | 63.36 | 15.79 | 26 | 55355 | 853 | 56235833 |
Muscle spasms | 63.18 | 15.79 | 28 | 55353 | 137343 | 56099343 |
Metastases to skin | 62.66 | 15.79 | 30 | 55351 | 1428 | 56235258 |
Gastrointestinal perforation | 62.32 | 15.79 | 39 | 55342 | 3160 | 56233526 |
Decreased appetite | 61.20 | 15.79 | 397 | 54984 | 218834 | 56017852 |
Metastases to bone | 60.72 | 15.79 | 85 | 55296 | 19423 | 56217263 |
Leukoencephalopathy | 60.62 | 15.79 | 42 | 55339 | 4040 | 56232646 |
Discomfort | 60.46 | 15.79 | 32 | 55349 | 141729 | 56094957 |
Renal tubular necrosis | 59.65 | 15.79 | 63 | 55318 | 10765 | 56225921 |
Diarrhoea | 59.21 | 15.79 | 918 | 54463 | 637589 | 55599097 |
Pleural effusion | 58.36 | 15.79 | 201 | 55180 | 85279 | 56151407 |
Infusion related reaction | 58.18 | 15.79 | 72 | 55309 | 208859 | 56027827 |
Metastases to breast | 56.29 | 15.79 | 18 | 55363 | 282 | 56236404 |
Abdominal pain | 56.17 | 15.79 | 441 | 54940 | 258364 | 55978322 |
Deafness bilateral | 55.83 | 15.79 | 27 | 55354 | 1314 | 56235372 |
Osteoarthritis | 55.08 | 15.79 | 7 | 55374 | 80289 | 56156397 |
Polyneuropathy | 54.92 | 15.79 | 66 | 55315 | 12984 | 56223702 |
Loss of personal independence in daily activities | 53.67 | 15.79 | 8 | 55373 | 81361 | 56155325 |
Alopecia | 52.84 | 15.79 | 133 | 55248 | 293325 | 55943361 |
Blood creatinine increased | 52.52 | 15.79 | 186 | 55195 | 80005 | 56156681 |
Large intestine perforation | 51.13 | 15.79 | 50 | 55331 | 7801 | 56228885 |
Urticaria | 50.40 | 15.79 | 41 | 55340 | 144635 | 56092051 |
Deep vein thrombosis | 49.09 | 15.79 | 177 | 55204 | 76800 | 56159886 |
Gait disturbance | 49 | 15.79 | 53 | 55328 | 163268 | 56073418 |
Inappropriate antidiuretic hormone secretion | 49.00 | 15.79 | 64 | 55317 | 13692 | 56222994 |
Myasthenia gravis crisis | 48.56 | 15.79 | 18 | 55363 | 447 | 56236239 |
Haemoglobin decreased | 48.43 | 15.79 | 260 | 55121 | 133877 | 56102809 |
Overdose | 47.98 | 15.79 | 22 | 55359 | 105808 | 56130878 |
Metastases to peritoneum | 47.19 | 15.79 | 32 | 55349 | 2972 | 56233714 |
Fatigue | 46.76 | 15.79 | 524 | 54857 | 788028 | 55448658 |
Fibromyalgia | 46.75 | 15.79 | 3 | 55378 | 59600 | 56177086 |
Feeling abnormal | 46.36 | 15.79 | 38 | 55343 | 133564 | 56103122 |
Depression | 46.13 | 15.79 | 66 | 55315 | 180051 | 56056635 |
Peripheral artery thrombosis | 45.94 | 15.79 | 26 | 55355 | 1751 | 56234935 |
Injection site erythema | 45.93 | 15.79 | 10 | 55371 | 77438 | 56159248 |
Encephalopathy | 45.90 | 15.79 | 105 | 55276 | 35220 | 56201466 |
Mobility decreased | 45.78 | 15.79 | 20 | 55361 | 98971 | 56137715 |
Suicidal ideation | 45.01 | 15.79 | 3 | 55378 | 57739 | 56178947 |
Bronchitis | 44.12 | 15.79 | 28 | 55353 | 112283 | 56124403 |
Mesenteric abscess | 41.43 | 15.79 | 11 | 55370 | 85 | 56236601 |
Plasma cell leukaemia | 40.92 | 15.79 | 21 | 55360 | 1162 | 56235524 |
Drug clearance decreased | 40.88 | 15.79 | 22 | 55359 | 1342 | 56235344 |
Malignant transformation | 40.56 | 15.79 | 15 | 55366 | 370 | 56236316 |
Chemical peritonitis | 40.45 | 15.79 | 11 | 55370 | 94 | 56236592 |
Hospitalisation | 40.03 | 15.79 | 12 | 55369 | 74988 | 56161698 |
Ileus | 39.55 | 15.79 | 58 | 55323 | 13824 | 56222862 |
Cystitis haemorrhagic | 39.45 | 15.79 | 32 | 55349 | 3905 | 56232781 |
Injury | 39.21 | 15.79 | 6 | 55375 | 59845 | 56176841 |
Bicytopenia | 39.05 | 15.79 | 25 | 55356 | 2108 | 56234578 |
Large intestinal ulcer perforation | 38.91 | 15.79 | 10 | 55371 | 67 | 56236619 |
Cytopenia | 38.88 | 15.79 | 48 | 55333 | 9707 | 56226979 |
Somnolence | 38.83 | 15.79 | 63 | 55318 | 163350 | 56073336 |
Asthenia | 38.36 | 15.79 | 510 | 54871 | 342463 | 55894223 |
Anastomotic leak | 38.19 | 15.79 | 15 | 55366 | 438 | 56236248 |
Lower respiratory tract infection | 38.18 | 15.79 | 34 | 55347 | 114760 | 56121926 |
Recall phenomenon | 37.91 | 15.79 | 16 | 55365 | 564 | 56236122 |
Gastric perforation | 37.88 | 15.79 | 22 | 55359 | 1556 | 56235130 |
Cervix carcinoma recurrent | 37.76 | 15.79 | 9 | 55372 | 42 | 56236644 |
Performance status decreased | 37.58 | 15.79 | 29 | 55352 | 3294 | 56233392 |
Adverse drug reaction | 37.44 | 15.79 | 9 | 55372 | 65123 | 56171563 |
Wernicke's encephalopathy | 37.40 | 15.79 | 8 | 55373 | 20 | 56236666 |
Exposure during pregnancy | 36.88 | 15.79 | 48 | 55333 | 136294 | 56100392 |
Cervix neoplasm | 36.67 | 15.79 | 12 | 55369 | 203 | 56236483 |
Ureteric rupture | 36.63 | 15.79 | 7 | 55374 | 7 | 56236679 |
Cataract | 36.30 | 15.79 | 4 | 55377 | 51243 | 56185443 |
Nasal abscess | 36.22 | 15.79 | 11 | 55370 | 144 | 56236542 |
Balance disorder | 36.12 | 15.79 | 15 | 55366 | 76505 | 56160181 |
Dermatitis | 35.71 | 15.79 | 58 | 55323 | 15099 | 56221587 |
Embryonal rhabdomyosarcoma | 35.70 | 15.79 | 7 | 55374 | 9 | 56236677 |
Nephritis bacterial | 35.62 | 15.79 | 8 | 55373 | 27 | 56236659 |
Maternal exposure during pregnancy | 35.59 | 15.79 | 84 | 55297 | 189469 | 56047217 |
Bladder perforation | 35.41 | 15.79 | 11 | 55370 | 156 | 56236530 |
Dizziness | 35.33 | 15.79 | 221 | 55160 | 375919 | 55860767 |
Blood cholesterol increased | 34.62 | 15.79 | 14 | 55367 | 72565 | 56164121 |
Metastases to abdominal wall | 34.59 | 15.79 | 10 | 55371 | 109 | 56236577 |
Pericardial effusion | 34.45 | 15.79 | 80 | 55301 | 27095 | 56209591 |
Cardiac tamponade | 34.21 | 15.79 | 31 | 55350 | 4395 | 56232291 |
Radiation injury | 34.18 | 15.79 | 14 | 55367 | 457 | 56236229 |
Intentional product misuse | 34.11 | 15.79 | 5 | 55376 | 51499 | 56185187 |
Gastrointestinal fungal infection | 34.08 | 15.79 | 12 | 55369 | 256 | 56236430 |
Nasal congestion | 33.99 | 15.79 | 7 | 55374 | 56363 | 56180323 |
Cerebral venous thrombosis | 33.98 | 15.79 | 22 | 55359 | 1891 | 56234795 |
Melanoderma | 33.96 | 15.79 | 11 | 55370 | 180 | 56236506 |
Injection site reaction | 33.40 | 15.79 | 6 | 55375 | 53241 | 56183445 |
Neutropenic colitis | 33.36 | 15.79 | 25 | 55356 | 2718 | 56233968 |
Lung adenocarcinoma | 33.33 | 15.79 | 31 | 55350 | 4543 | 56232143 |
Treatment failure | 33.20 | 15.79 | 74 | 55307 | 170318 | 56066368 |
Adverse event | 33.14 | 15.79 | 7 | 55374 | 55369 | 56181317 |
Unevaluable event | 33.08 | 15.79 | 4 | 55377 | 47683 | 56189003 |
Folliculitis | 32.80 | 15.79 | 7 | 55374 | 54972 | 56181714 |
Varicella zoster virus infection | 32.43 | 15.79 | 24 | 55357 | 2560 | 56234126 |
Chloroma | 32.28 | 15.79 | 11 | 55370 | 212 | 56236474 |
Stress | 32.22 | 15.79 | 9 | 55372 | 58901 | 56177785 |
Malnutrition | 32.19 | 15.79 | 53 | 55328 | 13955 | 56222731 |
Peripheral ischaemia | 32.05 | 15.79 | 30 | 55351 | 4433 | 56232253 |
Cerebellar haemangioma | 32.02 | 15.79 | 9 | 55372 | 88 | 56236598 |
Osteosarcoma | 31.74 | 15.79 | 10 | 55371 | 149 | 56236537 |
Haemophagocytic lymphohistiocytosis | 31.73 | 15.79 | 43 | 55338 | 9529 | 56227157 |
Tumour haemorrhage | 31.46 | 15.79 | 19 | 55362 | 1445 | 56235241 |
Metastases to adrenals | 31.42 | 15.79 | 15 | 55366 | 709 | 56235977 |
Axillary vein thrombosis | 31.30 | 15.79 | 12 | 55369 | 328 | 56236358 |
Herpes simplex encephalitis | 31.19 | 15.79 | 12 | 55369 | 331 | 56236355 |
Wheezing | 30.44 | 15.79 | 18 | 55363 | 75008 | 56161678 |
Venoocclusive liver disease | 30.38 | 15.79 | 29 | 55352 | 4392 | 56232294 |
Metastasis | 30.28 | 15.79 | 30 | 55351 | 4754 | 56231932 |
Enteritis | 30.27 | 15.79 | 37 | 55344 | 7406 | 56229280 |
Respiratory failure | 30.14 | 15.79 | 178 | 55203 | 94884 | 56141802 |
Vesical fistula | 30.00 | 15.79 | 8 | 55373 | 63 | 56236623 |
Anxiety | 29.96 | 15.79 | 94 | 55287 | 193078 | 56043608 |
Cervix carcinoma | 29.93 | 15.79 | 24 | 55357 | 2881 | 56233805 |
Abortion spontaneous | 29.56 | 15.79 | 4 | 55377 | 43749 | 56192937 |
Haemolytic uraemic syndrome | 29.40 | 15.79 | 22 | 55359 | 2386 | 56234300 |
Product use issue | 29.22 | 15.79 | 90 | 55291 | 185951 | 56050735 |
Peripheral sensory neuropathy | 28.97 | 15.79 | 35 | 55346 | 6921 | 56229765 |
Neoplasm recurrence | 28.95 | 15.79 | 22 | 55359 | 2442 | 56234244 |
Diffuse large B-cell lymphoma | 28.73 | 15.79 | 35 | 55346 | 6981 | 56229705 |
Ovarian cancer | 28.66 | 15.79 | 33 | 55348 | 6205 | 56230481 |
White blood cell count abnormal | 28.59 | 15.79 | 32 | 55349 | 5835 | 56230851 |
Osteoporosis | 28.38 | 15.79 | 8 | 55373 | 52044 | 56184642 |
Dysphagia | 28.31 | 15.79 | 157 | 55224 | 81790 | 56154896 |
Female genital tract fistula | 28.12 | 15.79 | 28 | 55353 | 4464 | 56232222 |
Wrong technique in product usage process | 28.11 | 15.79 | 11 | 55370 | 58157 | 56178529 |
Sinus polyp | 27.95 | 15.79 | 11 | 55370 | 323 | 56236363 |
Vena cava thrombosis | 27.74 | 15.79 | 20 | 55361 | 2049 | 56234637 |
Acoustic stimulation tests abnormal | 27.61 | 15.79 | 8 | 55373 | 88 | 56236598 |
Disseminated intravascular coagulation | 27.61 | 15.79 | 57 | 55324 | 17828 | 56218858 |
Enterocolitis infectious | 27.51 | 15.79 | 18 | 55363 | 1575 | 56235111 |
Impaired healing | 27.36 | 15.79 | 27 | 55354 | 86814 | 56149872 |
Inappropriate schedule of product administration | 27.36 | 15.79 | 25 | 55356 | 83362 | 56153324 |
Gastrooesophageal reflux disease | 27.27 | 15.79 | 25 | 55356 | 83232 | 56153454 |
Memory impairment | 27.17 | 15.79 | 27 | 55354 | 86530 | 56150156 |
Hypophosphataemia | 26.87 | 15.79 | 40 | 55341 | 9662 | 56227024 |
Alveolar soft part sarcoma | 26.75 | 15.79 | 8 | 55373 | 99 | 56236587 |
Adrenocortical carcinoma | 26.72 | 15.79 | 7 | 55374 | 51 | 56236635 |
Malaise | 26.46 | 15.79 | 233 | 55148 | 367627 | 55869059 |
Cervix cancer metastatic | 26.37 | 15.79 | 7 | 55374 | 54 | 56236632 |
Suicide attempt | 26.24 | 15.79 | 12 | 55369 | 57824 | 56178862 |
Chronic kidney disease | 26.20 | 15.79 | 96 | 55285 | 41960 | 56194726 |
Pneumonia salmonella | 26.17 | 15.79 | 5 | 55376 | 5 | 56236681 |
Radiation pneumonitis | 26.14 | 15.79 | 17 | 55364 | 1472 | 56235214 |
Clostridium bacteraemia | 25.92 | 15.79 | 9 | 55372 | 184 | 56236502 |
Intestinal perforation | 25.90 | 15.79 | 42 | 55339 | 10917 | 56225769 |
Acquired gene mutation | 25.73 | 15.79 | 14 | 55367 | 873 | 56235813 |
Ill-defined disorder | 25.68 | 15.79 | 18 | 55363 | 68525 | 56168161 |
Hypoalbuminaemia | 25.57 | 15.79 | 41 | 55340 | 10558 | 56226128 |
Bacteraemia | 25.53 | 15.79 | 51 | 55330 | 15580 | 56221106 |
Thymus enlargement | 25.53 | 15.79 | 8 | 55373 | 117 | 56236569 |
Hypersensitivity | 25.44 | 15.79 | 148 | 55233 | 256260 | 55980426 |
Aortic embolus | 25.35 | 15.79 | 6 | 55375 | 27 | 56236659 |
Osteosarcoma metastatic | 25.35 | 15.79 | 6 | 55375 | 27 | 56236659 |
Neutrophil count abnormal | 25.28 | 15.79 | 21 | 55360 | 2649 | 56234037 |
Fistula of small intestine | 24.81 | 15.79 | 10 | 55371 | 313 | 56236373 |
Metastases to abdominal cavity | 24.74 | 15.79 | 11 | 55370 | 441 | 56236245 |
Amputation stump pain | 24.67 | 15.79 | 6 | 55375 | 31 | 56236655 |
Multiple organ dysfunction syndrome | 24.54 | 15.79 | 110 | 55271 | 52660 | 56184026 |
Respiratory symptom | 24.48 | 15.79 | 21 | 55360 | 2769 | 56233917 |
Influenza like illness | 24.23 | 15.79 | 15 | 55366 | 60973 | 56175713 |
Metastases to meninges | 23.91 | 15.79 | 19 | 55362 | 2251 | 56234435 |
Stem cell transplant | 23.71 | 15.79 | 17 | 55364 | 1727 | 56234959 |
Jaw operation | 23.58 | 15.79 | 13 | 55368 | 832 | 56235854 |
Thrombotic microangiopathy | 23.52 | 15.79 | 37 | 55344 | 9374 | 56227312 |
Extremity necrosis | 23.44 | 15.79 | 16 | 55365 | 1502 | 56235184 |
Arteriospasm coronary | 23.32 | 15.79 | 23 | 55358 | 3624 | 56233062 |
Oesophageal stenosis | 23.20 | 15.79 | 21 | 55360 | 2972 | 56233714 |
Pneumonitis | 23.09 | 15.79 | 76 | 55305 | 31488 | 56205198 |
Acute respiratory distress syndrome | 22.96 | 15.79 | 60 | 55321 | 21866 | 56214820 |
Enterococcal sepsis | 22.90 | 15.79 | 15 | 55366 | 1315 | 56235371 |
Embolism | 22.79 | 15.79 | 32 | 55349 | 7332 | 56229354 |
Urinary tract infection bacterial | 22.71 | 15.79 | 25 | 55356 | 4475 | 56232211 |
Anti-Muellerian hormone level decreased | 22.68 | 15.79 | 7 | 55374 | 97 | 56236589 |
Radiation oesophagitis | 22.50 | 15.79 | 9 | 55372 | 276 | 56236410 |
Malignant peritoneal neoplasm | 22.42 | 15.79 | 12 | 55369 | 724 | 56235962 |
Acute myelomonocytic leukaemia | 22.32 | 15.79 | 8 | 55373 | 180 | 56236506 |
Gestational trophoblastic tumour | 22.31 | 15.79 | 6 | 55375 | 49 | 56236637 |
Burning sensation | 22.25 | 15.79 | 10 | 55371 | 48686 | 56188000 |
Incorrect dose administered | 22.19 | 15.79 | 12 | 55369 | 52535 | 56184151 |
Blood magnesium decreased | 22.17 | 15.79 | 41 | 55340 | 11833 | 56224853 |
Fluid retention | 21.90 | 15.79 | 13 | 55368 | 54065 | 56182621 |
Hypoaesthesia | 21.82 | 15.79 | 69 | 55312 | 141422 | 56095264 |
Odynophagia | 21.65 | 15.79 | 30 | 55351 | 6788 | 56229898 |
Ovarian vein thrombosis | 21.50 | 15.79 | 6 | 55375 | 57 | 56236629 |
Femur fracture | 21.49 | 15.79 | 6 | 55375 | 39289 | 56197397 |
Vascular compression | 21.47 | 15.79 | 7 | 55374 | 117 | 56236569 |
Oroticaciduria | 21.47 | 15.79 | 4 | 55377 | 3 | 56236683 |
Influenza | 21.44 | 15.79 | 38 | 55343 | 95223 | 56141463 |
Sleep disorder | 21.36 | 15.79 | 21 | 55360 | 67642 | 56169044 |
Median nerve injury | 21.22 | 15.79 | 5 | 55376 | 22 | 56236664 |
Tachycardia | 21.06 | 15.79 | 177 | 55204 | 105699 | 56130987 |
Failure to thrive | 21 | 15.79 | 29 | 55352 | 6541 | 56230145 |
Maternal death affecting foetus | 20.93 | 15.79 | 4 | 55377 | 4 | 56236682 |
Therapy responder | 20.87 | 15.79 | 9 | 55372 | 335 | 56236351 |
Lymphopenia | 20.84 | 15.79 | 49 | 55332 | 16725 | 56219961 |
Blood glucose increased | 20.78 | 15.79 | 26 | 55355 | 75125 | 56161561 |
Vision blurred | 20.62 | 15.79 | 31 | 55350 | 82912 | 56153774 |
Blood pressure fluctuation | 20.57 | 15.79 | 7 | 55374 | 40353 | 56196333 |
Pulmonary vascular disorder | 20.50 | 15.79 | 9 | 55372 | 350 | 56236336 |
Cytomegalovirus infection | 20.41 | 15.79 | 53 | 55328 | 19243 | 56217443 |
Blood sodium decreased | 20.28 | 15.79 | 58 | 55323 | 22276 | 56214410 |
Small cell lung cancer | 20.18 | 15.79 | 15 | 55366 | 1611 | 56235075 |
Pregnancy | 20.13 | 15.79 | 4 | 55377 | 33029 | 56203657 |
Radiation proctitis | 20.04 | 15.79 | 4 | 55377 | 6 | 56236680 |
Superior sagittal sinus thrombosis | 19.78 | 15.79 | 11 | 55370 | 716 | 56235970 |
Peritonitis | 19.77 | 15.79 | 47 | 55334 | 16155 | 56220531 |
VIth nerve paresis | 19.72 | 15.79 | 6 | 55375 | 79 | 56236607 |
Renal-limited thrombotic microangiopathy | 19.66 | 15.79 | 4 | 55377 | 7 | 56236679 |
Refeeding syndrome | 19.65 | 15.79 | 5 | 55376 | 32 | 56236654 |
Metastases to pelvis | 19.65 | 15.79 | 9 | 55372 | 387 | 56236299 |
Hiccups | 19.59 | 15.79 | 16 | 55365 | 1972 | 56234714 |
Diabetes mellitus | 19.56 | 15.79 | 14 | 55367 | 52721 | 56183965 |
Neck pain | 19.55 | 15.79 | 19 | 55362 | 61536 | 56175150 |
Gastrointestinal necrosis | 19.53 | 15.79 | 18 | 55363 | 2608 | 56234078 |
Radiation mucositis | 19.52 | 15.79 | 5 | 55376 | 33 | 56236653 |
Respiratory distress | 19.49 | 15.79 | 72 | 55309 | 31595 | 56205091 |
Drug clearance increased | 19.26 | 15.79 | 6 | 55375 | 86 | 56236600 |
Myalgia | 19.24 | 15.79 | 66 | 55315 | 131959 | 56104727 |
Granulocytopenia | 19.24 | 15.79 | 25 | 55356 | 5319 | 56231367 |
Leukaemic lymphoma | 19.19 | 15.79 | 6 | 55375 | 87 | 56236599 |
Lymphangioleiomyomatosis | 19.19 | 15.79 | 7 | 55374 | 166 | 56236520 |
Purulent pericarditis | 19.02 | 15.79 | 5 | 55376 | 37 | 56236649 |
Product quality issue | 19.01 | 15.79 | 4 | 55377 | 31732 | 56204954 |
Medulloblastoma recurrent | 19.00 | 15.79 | 6 | 55375 | 90 | 56236596 |
Salivary gland cancer | 18.80 | 15.79 | 7 | 55374 | 176 | 56236510 |
Low cardiac output syndrome | 18.77 | 15.79 | 8 | 55373 | 289 | 56236397 |
Aortitis | 18.72 | 15.79 | 12 | 55369 | 1014 | 56235672 |
Marchiafava-Bignami disease | 18.70 | 15.79 | 4 | 55377 | 10 | 56236676 |
Hepatic lesion | 18.69 | 15.79 | 22 | 55359 | 4233 | 56232453 |
Cannabinoid hyperemesis syndrome | 18.68 | 15.79 | 5 | 55376 | 40 | 56236646 |
Pain in jaw | 18.65 | 15.79 | 8 | 55373 | 40028 | 56196658 |
Cerebral salt-wasting syndrome | 18.57 | 15.79 | 5 | 55376 | 41 | 56236645 |
Dry eye | 18.54 | 15.79 | 6 | 55375 | 35710 | 56200976 |
Gastroenteritis radiation | 18.42 | 15.79 | 9 | 55372 | 448 | 56236238 |
Mucosal erosion | 18.33 | 15.79 | 13 | 55368 | 1298 | 56235388 |
Sweat gland tumour | 18.31 | 15.79 | 6 | 55375 | 102 | 56236584 |
Hypoacusis | 18.30 | 15.79 | 55 | 55326 | 21713 | 56214973 |
Gastric disorder | 18.29 | 15.79 | 5 | 55376 | 33205 | 56203481 |
Blood pressure increased | 18.29 | 15.79 | 77 | 55304 | 145099 | 56091587 |
Pelvic fluid collection | 18.29 | 15.79 | 11 | 55370 | 830 | 56235856 |
Muscular weakness | 18.25 | 15.79 | 48 | 55333 | 104404 | 56132282 |
Sinus tachycardia | 18.21 | 15.79 | 56 | 55325 | 22388 | 56214298 |
Hypoglycaemia | 17.99 | 15.79 | 17 | 55364 | 55798 | 56180888 |
Proctitis | 17.98 | 15.79 | 17 | 55364 | 2543 | 56234143 |
Cerebral ischaemia | 17.96 | 15.79 | 26 | 55355 | 6124 | 56230562 |
Uterine atrophy | 17.87 | 15.79 | 5 | 55376 | 48 | 56236638 |
Road traffic accident | 17.84 | 15.79 | 3 | 55378 | 27924 | 56208762 |
Urinary tract toxicity | 17.78 | 15.79 | 3 | 55378 | 0 | 56236686 |
Emphysematous cholecystitis | 17.78 | 15.79 | 3 | 55378 | 0 | 56236686 |
Hypoglossal nerve paresis | 17.74 | 15.79 | 6 | 55375 | 113 | 56236573 |
Multiple sclerosis | 17.73 | 15.79 | 3 | 55378 | 27799 | 56208887 |
Metastases to pleura | 17.71 | 15.79 | 13 | 55368 | 1369 | 56235317 |
Tumour thrombosis | 17.70 | 15.79 | 4 | 55377 | 14 | 56236672 |
Transdifferentiation of neoplasm | 17.70 | 15.79 | 4 | 55377 | 14 | 56236672 |
Osteoradionecrosis | 17.59 | 15.79 | 6 | 55375 | 116 | 56236570 |
Ovarian disorder | 17.54 | 15.79 | 10 | 55371 | 683 | 56236003 |
Bursitis | 17.53 | 15.79 | 3 | 55378 | 27579 | 56209107 |
Aorto-oesophageal fistula | 17.48 | 15.79 | 4 | 55377 | 15 | 56236671 |
Central obesity | 17.46 | 15.79 | 12 | 55369 | 1139 | 56235547 |
Roseolovirus test positive | 17.42 | 15.79 | 5 | 55376 | 53 | 56236633 |
Tearfulness | 17.42 | 15.79 | 20 | 55361 | 3748 | 56232938 |
Neuroblastoma | 17.40 | 15.79 | 6 | 55375 | 120 | 56236566 |
Neurosensory hypoacusis | 17.34 | 15.79 | 7 | 55374 | 220 | 56236466 |
Necrosis | 17.34 | 15.79 | 23 | 55358 | 4993 | 56231693 |
Cardiopulmonary failure | 17.24 | 15.79 | 19 | 55362 | 3406 | 56233280 |
Staphylococcal infection | 17.18 | 15.79 | 78 | 55303 | 37540 | 56199146 |
Urogenital disorder | 17.09 | 15.79 | 5 | 55376 | 57 | 56236629 |
Liver abscess | 17.08 | 15.79 | 17 | 55364 | 2709 | 56233977 |
Ovarian failure | 16.96 | 15.79 | 12 | 55369 | 1193 | 56235493 |
Deafness neurosensory | 16.95 | 15.79 | 22 | 55359 | 4676 | 56232010 |
Abdominal compartment syndrome | 16.84 | 15.79 | 9 | 55372 | 541 | 56236145 |
Necrotising colitis | 16.81 | 15.79 | 9 | 55372 | 543 | 56236143 |
Chronic obstructive pulmonary disease | 16.80 | 15.79 | 19 | 55362 | 57396 | 56179290 |
Melanosis | 16.72 | 15.79 | 4 | 55377 | 19 | 56236667 |
Blood culture positive | 16.70 | 15.79 | 21 | 55360 | 4325 | 56232361 |
Confusional state | 16.69 | 15.79 | 128 | 55253 | 208027 | 56028659 |
Renal tubular dysfunction | 16.63 | 15.79 | 8 | 55373 | 385 | 56236301 |
Joint stiffness | 16.62 | 15.79 | 7 | 55374 | 35418 | 56201268 |
Tumour invasion | 16.58 | 15.79 | 6 | 55375 | 139 | 56236547 |
Plasma cell myeloma | 16.53 | 15.79 | 90 | 55291 | 46556 | 56190130 |
Blood phosphorus decreased | 16.47 | 15.79 | 20 | 55361 | 3977 | 56232709 |
Lip swelling | 16.39 | 15.79 | 3 | 55378 | 26269 | 56210417 |
Clostridium difficile colitis | 16.38 | 15.79 | 48 | 55333 | 18690 | 56217996 |
Myasthenic syndrome | 16.37 | 15.79 | 7 | 55374 | 255 | 56236431 |
Eye pain | 16.34 | 15.79 | 5 | 55376 | 30842 | 56205844 |
Fanconi syndrome | 16.29 | 15.79 | 12 | 55369 | 1271 | 56235415 |
Stent malfunction | 16.29 | 15.79 | 5 | 55376 | 68 | 56236618 |
Pseudomonal sepsis | 16.29 | 15.79 | 15 | 55366 | 2171 | 56234515 |
Tracheal stenosis | 16.23 | 15.79 | 6 | 55375 | 148 | 56236538 |
Systemic infection | 16.22 | 15.79 | 18 | 55363 | 3251 | 56233435 |
Sedation | 16.17 | 15.79 | 7 | 55374 | 34847 | 56201839 |
Throat irritation | 16.09 | 15.79 | 6 | 55375 | 32677 | 56204009 |
Neuromyopathy | 16.07 | 15.79 | 9 | 55372 | 594 | 56236092 |
Surgery | 15.93 | 15.79 | 6 | 55375 | 32480 | 56204206 |
Metastases to retroperitoneum | 15.86 | 15.79 | 6 | 55375 | 158 | 56236528 |
Hypoxia | 15.86 | 15.79 | 99 | 55282 | 53798 | 56182888 |
Skin toxicity | 15.85 | 15.79 | 20 | 55361 | 4133 | 56232553 |
Therapy interrupted | 15.83 | 15.79 | 3 | 55378 | 25622 | 56211064 |
MedDRA adverse event term | Likelihood ratio | Likelihood ratio threshold | Patients taking drug having adverse event | Patients taking drug not having adverse event | Patients not taking drug having adverse event | Patients not taking drug not having adverse event |
---|---|---|---|---|---|---|
Febrile neutropenia | 1406.68 | 13.19 | 1629 | 78290 | 120220 | 31497205 |
Neutropenia | 926.67 | 13.19 | 1429 | 78490 | 138935 | 31478490 |
Mucosal inflammation | 761.65 | 13.19 | 657 | 79262 | 33770 | 31583655 |
Thrombocytopenia | 552.10 | 13.19 | 1152 | 78767 | 141595 | 31475830 |
Malignant neoplasm progression | 486.07 | 13.19 | 780 | 79139 | 78218 | 31539207 |
Pancytopenia | 414.89 | 13.19 | 769 | 79150 | 86547 | 31530878 |
Disease progression | 394.32 | 13.19 | 768 | 79151 | 89696 | 31527729 |
Dehydration | 359.89 | 13.19 | 872 | 79047 | 118239 | 31499186 |
Bone marrow failure | 352.87 | 13.19 | 393 | 79526 | 27615 | 31589810 |
Leukopenia | 341.81 | 13.19 | 561 | 79358 | 57267 | 31560158 |
Myelosuppression | 340.31 | 13.19 | 290 | 79629 | 14630 | 31602795 |
Vomiting | 295.01 | 13.19 | 1230 | 78689 | 222743 | 31394682 |
Haematotoxicity | 280.73 | 13.19 | 192 | 79727 | 6945 | 31610480 |
Stomatitis | 275.14 | 13.19 | 413 | 79506 | 39025 | 31578400 |
Neutropenic sepsis | 260.84 | 13.19 | 230 | 79689 | 12149 | 31605276 |
Dysphagia | 247.76 | 13.19 | 487 | 79432 | 57189 | 31560236 |
Nausea | 241.36 | 13.19 | 1460 | 78459 | 306487 | 31310938 |
Neoplasm progression | 239.18 | 13.19 | 275 | 79644 | 19997 | 31597428 |
Acute myeloid leukaemia | 228.25 | 13.19 | 258 | 79661 | 18414 | 31599011 |
Anaemia | 222.03 | 13.19 | 1094 | 78825 | 212428 | 31404997 |
Second primary malignancy | 207.65 | 13.19 | 159 | 79760 | 6873 | 31610552 |
Drug abuse | 205.66 | 13.19 | 3 | 79916 | 87755 | 31529670 |
Neutrophil count decreased | 204.37 | 13.19 | 396 | 79523 | 45998 | 31571427 |
Product dose omission issue | 202.84 | 13.19 | 17 | 79902 | 105569 | 31511856 |
Arthralgia | 180.49 | 13.19 | 78 | 79841 | 151346 | 31466079 |
Pulmonary embolism | 177.74 | 13.19 | 530 | 79389 | 81116 | 31536309 |
Off label use | 172.11 | 13.19 | 1475 | 78444 | 345799 | 31271626 |
Therapy partial responder | 171.36 | 13.19 | 138 | 79781 | 6424 | 31611001 |
Aortic thrombosis | 170.30 | 13.19 | 65 | 79854 | 645 | 31616780 |
Nephropathy toxic | 168.79 | 13.19 | 174 | 79745 | 11179 | 31606246 |
Fall | 167.97 | 13.19 | 134 | 79785 | 185955 | 31431470 |
Renal salt-wasting syndrome | 154.41 | 13.19 | 48 | 79871 | 237 | 31617188 |
Myelodysplastic syndrome | 147.77 | 13.19 | 211 | 79708 | 19040 | 31598385 |
Drug interaction | 137.07 | 13.19 | 196 | 79723 | 208347 | 31409078 |
Pyrexia | 136.60 | 13.19 | 1264 | 78655 | 302576 | 31314849 |
Cardiotoxicity | 131.86 | 13.19 | 106 | 79813 | 4921 | 31612504 |
Decreased appetite | 131.40 | 13.19 | 745 | 79174 | 152472 | 31464953 |
Ototoxicity | 127.63 | 13.19 | 70 | 79849 | 1688 | 31615737 |
Tumour lysis syndrome | 123.07 | 13.19 | 172 | 79747 | 15213 | 31602212 |
Overdose | 115.38 | 13.19 | 35 | 79884 | 84629 | 31532796 |
Hyponatraemia | 114.96 | 13.19 | 428 | 79491 | 73371 | 31544054 |
Diffuse large B-cell lymphoma refractory | 112.90 | 13.19 | 55 | 79864 | 1028 | 31616397 |
Headache | 109.72 | 13.19 | 184 | 79735 | 183468 | 31433957 |
Septic shock | 109.21 | 13.19 | 391 | 79528 | 65767 | 31551658 |
White blood cell count decreased | 107.53 | 13.19 | 471 | 79448 | 86927 | 31530498 |
Diffuse large B-cell lymphoma recurrent | 107.52 | 13.19 | 76 | 79843 | 2899 | 31614526 |
Hypomagnesaemia | 105.88 | 13.19 | 180 | 79739 | 18878 | 31598547 |
Anastomotic leak | 104.56 | 13.19 | 44 | 79875 | 574 | 31616851 |
Weight increased | 101.51 | 13.19 | 41 | 79878 | 82906 | 31534519 |
Oesophagitis | 101.08 | 13.19 | 140 | 79779 | 12276 | 31605149 |
Acute kidney injury | 98.37 | 13.19 | 1107 | 78812 | 278607 | 31338818 |
Rhabdomyolysis | 94.73 | 13.19 | 22 | 79897 | 63559 | 31553866 |
Arterial thrombosis | 94.59 | 13.19 | 54 | 79865 | 1410 | 31616015 |
Depression | 94.30 | 13.19 | 56 | 79863 | 90759 | 31526666 |
Febrile bone marrow aplasia | 93.45 | 13.19 | 107 | 79812 | 7739 | 31609686 |
Cardiac failure congestive | 92.74 | 13.19 | 42 | 79877 | 79345 | 31538080 |
Psoriasis | 91.11 | 13.19 | 7 | 79912 | 46712 | 31570713 |
Rheumatoid arthritis | 90.92 | 13.19 | 8 | 79911 | 47801 | 31569624 |
Hypophagia | 90.77 | 13.19 | 183 | 79736 | 21859 | 31595566 |
Aorto-oesophageal fistula | 90.42 | 13.19 | 22 | 79897 | 31 | 31617394 |
Radiation skin injury | 89.96 | 13.19 | 41 | 79878 | 655 | 31616770 |
Metastases to lung | 88.94 | 13.19 | 108 | 79811 | 8314 | 31609111 |
Deafness | 88.20 | 13.19 | 120 | 79799 | 10345 | 31607080 |
Tinnitus | 86.84 | 13.19 | 151 | 79768 | 16124 | 31601301 |
Muscle spasms | 86.51 | 13.19 | 32 | 79887 | 68286 | 31549139 |
Odynophagia | 84.28 | 13.19 | 82 | 79837 | 4911 | 31612514 |
Hospitalisation | 83.18 | 13.19 | 13 | 79906 | 49794 | 31567631 |
Peripheral swelling | 82.29 | 13.19 | 34 | 79885 | 67831 | 31549594 |
Sepsis | 81.52 | 13.19 | 658 | 79261 | 151271 | 31466154 |
Anxiety | 81.43 | 13.19 | 66 | 79853 | 90967 | 31526458 |
Inappropriate antidiuretic hormone secretion | 80.39 | 13.19 | 120 | 79799 | 11267 | 31606158 |
Osteoradionecrosis | 80.11 | 13.19 | 22 | 79897 | 63 | 31617362 |
Gastric perforation | 80.06 | 13.19 | 58 | 79861 | 2301 | 31615124 |
Platelet count decreased | 79.88 | 13.19 | 514 | 79405 | 109921 | 31507504 |
Metastases to central nervous system | 79.15 | 13.19 | 97 | 79822 | 7539 | 31609886 |
Intentional product misuse | 79.04 | 13.19 | 4 | 79915 | 37947 | 31579478 |
Suicide attempt | 77.34 | 13.19 | 4 | 79915 | 37244 | 31580181 |
Peripheral ischaemia | 76.55 | 13.19 | 80 | 79839 | 5220 | 31612205 |
Vena cava thrombosis | 75.90 | 13.19 | 42 | 79877 | 1031 | 31616394 |
Musculoskeletal stiffness | 75.72 | 13.19 | 8 | 79911 | 41317 | 31576108 |
Insomnia | 75.03 | 13.19 | 77 | 79842 | 94759 | 31522666 |
Joint swelling | 74.77 | 13.19 | 21 | 79898 | 53410 | 31564015 |
Asthma | 73.75 | 13.19 | 10 | 79909 | 42601 | 31574824 |
Product use in unapproved indication | 73.20 | 13.19 | 464 | 79455 | 98707 | 31518718 |
Nasopharyngitis | 73.01 | 13.19 | 34 | 79885 | 63211 | 31554214 |
Suicidal ideation | 72.29 | 13.19 | 5 | 79914 | 36401 | 31581024 |
Peripheral artery thrombosis | 71.93 | 13.19 | 53 | 79866 | 2159 | 31615266 |
Myalgia | 71.64 | 13.19 | 54 | 79865 | 77204 | 31540221 |
Pneumonitis | 71.40 | 13.19 | 204 | 79715 | 30448 | 31586977 |
Osteosarcoma | 71.18 | 13.19 | 27 | 79892 | 263 | 31617162 |
Blood pressure increased | 69.65 | 13.19 | 59 | 79860 | 79574 | 31537851 |
Oesophageal fistula | 68.95 | 13.19 | 25 | 79894 | 212 | 31617213 |
Pain in extremity | 67.86 | 13.19 | 118 | 79801 | 116085 | 31501340 |
Neutropenic colitis | 66.88 | 13.19 | 55 | 79864 | 2637 | 31614788 |
Hypokalaemia | 66.80 | 13.19 | 290 | 79629 | 53284 | 31564141 |
Inappropriate schedule of product administration | 65.70 | 13.19 | 23 | 79896 | 50800 | 31566625 |
Aplasia | 65.34 | 13.19 | 66 | 79853 | 4137 | 31613288 |
Gastrointestinal toxicity | 64.03 | 13.19 | 50 | 79869 | 2224 | 31615201 |
Splenic infarction | 62.42 | 13.19 | 46 | 79873 | 1874 | 31615551 |
Deafness neurosensory | 62.32 | 13.19 | 53 | 79866 | 2663 | 31614762 |
Bacterial translocation | 61.27 | 13.19 | 25 | 79894 | 300 | 31617125 |
Condition aggravated | 60.81 | 13.19 | 211 | 79708 | 163798 | 31453627 |
Renal failure | 60.69 | 13.19 | 524 | 79395 | 122806 | 31494619 |
General physical health deterioration | 60.62 | 13.19 | 491 | 79428 | 112944 | 31504481 |
Dermatitis | 60.16 | 13.19 | 90 | 79829 | 8466 | 31608959 |
Prostate cancer | 60.16 | 13.19 | 11 | 79908 | 37590 | 31579835 |
Death | 59.97 | 13.19 | 601 | 79318 | 359968 | 31257457 |
Injection site pain | 57.91 | 13.19 | 9 | 79910 | 34625 | 31582800 |
Metastases to liver | 57.64 | 13.19 | 110 | 79809 | 12617 | 31604808 |
Cardiac disorder | 57.55 | 13.19 | 14 | 79905 | 39200 | 31578225 |
Dizziness | 57.15 | 13.19 | 283 | 79636 | 198864 | 31418561 |
Radiation pneumonitis | 56.71 | 13.19 | 48 | 79871 | 2396 | 31615029 |
Portal venous gas | 55.83 | 13.19 | 24 | 79895 | 331 | 31617094 |
Aggression | 55.34 | 13.19 | 13 | 79906 | 37278 | 31580147 |
Wheezing | 54.50 | 13.19 | 12 | 79907 | 35974 | 31581451 |
Hypertension | 54.36 | 13.19 | 155 | 79764 | 127945 | 31489480 |
Oesophagobronchial fistula | 53.25 | 13.19 | 19 | 79900 | 153 | 31617272 |
Heart rate decreased | 53.01 | 13.19 | 5 | 79914 | 28261 | 31589164 |
Pruritus | 52.71 | 13.19 | 152 | 79767 | 125015 | 31492410 |
COVID-19 | 52.52 | 13.19 | 37 | 79882 | 54784 | 31562641 |
Hiccups | 51.95 | 13.19 | 88 | 79831 | 9199 | 31608226 |
Hypocalcaemia | 51.88 | 13.19 | 147 | 79772 | 21831 | 31595594 |
Malignant transformation | 51.75 | 13.19 | 30 | 79889 | 807 | 31616618 |
Tumour necrosis | 51.62 | 13.19 | 34 | 79885 | 1153 | 31616272 |
Thrombotic microangiopathy | 51.51 | 13.19 | 88 | 79831 | 9263 | 31608162 |
Renal impairment | 51.23 | 13.19 | 383 | 79536 | 85966 | 31531459 |
Radiation oesophagitis | 51.10 | 13.19 | 24 | 79895 | 412 | 31617013 |
Atypical haemolytic uraemic syndrome | 51.06 | 13.19 | 20 | 79899 | 214 | 31617211 |
Tremor | 50.89 | 13.19 | 71 | 79848 | 76349 | 31541076 |
Colitis | 50.60 | 13.19 | 194 | 79725 | 33693 | 31583732 |
Hepatitis B | 49.79 | 13.19 | 67 | 79852 | 5714 | 31611711 |
Gait disturbance | 49.63 | 13.19 | 74 | 79845 | 77421 | 31540004 |
Blood creatine phosphokinase increased | 49.32 | 13.19 | 22 | 79897 | 41952 | 31575473 |
Vision blurred | 49.20 | 13.19 | 22 | 79897 | 41893 | 31575532 |
Salivary gland cancer | 49.02 | 13.19 | 21 | 79898 | 287 | 31617138 |
Hallucination | 49.02 | 13.19 | 28 | 79891 | 46382 | 31571043 |
Electrolyte imbalance | 48.98 | 13.19 | 100 | 79819 | 12048 | 31605377 |
Oesophageal stenosis | 48.87 | 13.19 | 37 | 79882 | 1571 | 31615854 |
Pulmonary vascular disorder | 48.58 | 13.19 | 26 | 79893 | 596 | 31616829 |
Acute respiratory distress syndrome | 48.35 | 13.19 | 154 | 79765 | 24386 | 31593039 |
Neuropathy peripheral | 48.00 | 13.19 | 341 | 79578 | 75308 | 31542117 |
Influenza | 47.89 | 13.19 | 26 | 79893 | 44299 | 31573126 |
Leukoencephalopathy | 47.80 | 13.19 | 54 | 79865 | 3848 | 31613577 |
Feeling abnormal | 47.70 | 13.19 | 44 | 79875 | 56958 | 31560467 |
Disease recurrence | 47.20 | 13.19 | 128 | 79791 | 18533 | 31598892 |
Foetal exposure during pregnancy | 47.13 | 13.19 | 22 | 79897 | 40854 | 31576571 |
Respiratory failure | 46.25 | 13.19 | 424 | 79495 | 101025 | 31516400 |
Mobility decreased | 46.24 | 13.19 | 7 | 79912 | 27462 | 31589963 |
B-cell lymphoma recurrent | 46.13 | 13.19 | 26 | 79893 | 662 | 31616763 |
Ameloblastoma | 45.96 | 13.19 | 15 | 79904 | 89 | 31617336 |
Bacteraemia | 45.65 | 13.19 | 122 | 79797 | 17512 | 31599913 |
Coronary artery disease | 45.62 | 13.19 | 30 | 79889 | 46057 | 31571368 |
Wrong technique in product usage process | 45.00 | 13.19 | 14 | 79905 | 33329 | 31584096 |
Deep vein thrombosis | 44.66 | 13.19 | 284 | 79635 | 60452 | 31556973 |
Renal tubular disorder | 44.06 | 13.19 | 55 | 79864 | 4355 | 31613070 |
Somnolence | 43.91 | 13.19 | 118 | 79801 | 99327 | 31518098 |
Metastases to lymph nodes | 43.88 | 13.19 | 54 | 79865 | 4214 | 31613211 |
Arthritis | 43.83 | 13.19 | 8 | 79911 | 27377 | 31590048 |
Azoospermia | 43.52 | 13.19 | 21 | 79898 | 384 | 31617041 |
Carotid artery thrombosis | 43.25 | 13.19 | 20 | 79899 | 331 | 31617094 |
Renal infarct | 42.98 | 13.19 | 31 | 79888 | 1221 | 31616204 |
Urticaria | 42.91 | 13.19 | 49 | 79870 | 57468 | 31559957 |
Blood pressure fluctuation | 42.69 | 13.19 | 4 | 79915 | 22732 | 31594693 |
Intestinal ischaemia | 42.41 | 13.19 | 69 | 79850 | 6976 | 31610449 |
Cytomegalovirus oesophagitis | 42.38 | 13.19 | 22 | 79897 | 473 | 31616952 |
Drug hypersensitivity | 42.10 | 13.19 | 74 | 79845 | 72525 | 31544900 |
Enteritis | 42.02 | 13.19 | 69 | 79850 | 7030 | 31610395 |
Neoplasm recurrence | 41.98 | 13.19 | 38 | 79881 | 2076 | 31615349 |
Memory impairment | 41.73 | 13.19 | 22 | 79897 | 38108 | 31579317 |
Therapeutic product effect decreased | 41.40 | 13.19 | 14 | 79905 | 31608 | 31585817 |
Angioedema | 40.48 | 13.19 | 17 | 79902 | 33601 | 31583824 |
Incorrect dose administered | 40.06 | 13.19 | 20 | 79899 | 35732 | 31581693 |
Lymphopenia | 40.02 | 13.19 | 102 | 79817 | 14227 | 31603198 |
Pulmonary arteriopathy | 40.00 | 13.19 | 13 | 79906 | 76 | 31617349 |
Pain | 39.07 | 13.19 | 293 | 79626 | 186466 | 31430959 |
Adverse drug reaction | 38.98 | 13.19 | 8 | 79911 | 25193 | 31592232 |
Anastomotic complication | 38.96 | 13.19 | 19 | 79900 | 356 | 31617069 |
Embolism | 38.30 | 13.19 | 67 | 79852 | 7186 | 31610239 |
Pneumatosis intestinalis | 38.23 | 13.19 | 47 | 79872 | 3664 | 31613761 |
Bronchial fistula | 38.01 | 13.19 | 15 | 79904 | 164 | 31617261 |
Interstitial lung disease | 37.90 | 13.19 | 275 | 79644 | 61128 | 31556297 |
Tumour perforation | 37.56 | 13.19 | 17 | 79902 | 267 | 31617158 |
Balance disorder | 37.53 | 13.19 | 24 | 79895 | 37398 | 31580027 |
Influenza like illness | 37.48 | 13.19 | 9 | 79910 | 25428 | 31591997 |
Diarrhoea | 37.45 | 13.19 | 1157 | 78762 | 351252 | 31266173 |
Hypoglycaemia | 37.36 | 13.19 | 44 | 79875 | 50902 | 31566523 |
Alopecia | 37.30 | 13.19 | 126 | 79793 | 20569 | 31596856 |
Blood stem cell transplant failure | 37.00 | 13.19 | 19 | 79900 | 399 | 31617026 |
Tumour haemorrhage | 36.76 | 13.19 | 39 | 79880 | 2589 | 31614836 |
Chemotherapy | 36.72 | 13.19 | 21 | 79898 | 550 | 31616875 |
Radiation mucositis | 35.97 | 13.19 | 15 | 79904 | 191 | 31617234 |
Tracheo-oesophageal fistula | 35.96 | 13.19 | 19 | 79900 | 424 | 31617001 |
Cataract | 35.92 | 13.19 | 8 | 79911 | 23799 | 31593626 |
Electrocardiogram QT prolonged | 35.91 | 13.19 | 26 | 79893 | 37961 | 31579464 |
Metastasis | 35.89 | 13.19 | 45 | 79874 | 3579 | 31613846 |
Large intestine perforation | 35.82 | 13.19 | 67 | 79852 | 7569 | 31609856 |
Blood sodium decreased | 35.72 | 13.19 | 102 | 79817 | 15213 | 31602212 |
Product prescribing error | 35.47 | 13.19 | 4 | 79915 | 19638 | 31597787 |
Hypoacusis | 35.08 | 13.19 | 100 | 79819 | 14899 | 31602526 |
Neurosensory hypoacusis | 34.90 | 13.19 | 7 | 79912 | 0 | 31617425 |
Unevaluable event | 34.41 | 13.19 | 17 | 79902 | 30558 | 31586867 |
Teratoma | 34.39 | 13.19 | 9 | 79910 | 20 | 31617405 |
International normalised ratio increased | 34.30 | 13.19 | 38 | 79881 | 45185 | 31572240 |
Abdominal discomfort | 34.23 | 13.19 | 48 | 79871 | 51519 | 31565906 |
Osteoarthritis | 34.14 | 13.19 | 4 | 79915 | 19063 | 31598362 |
Rash | 33.71 | 13.19 | 335 | 79584 | 201151 | 31416274 |
Testicular germ cell cancer metastatic | 33.46 | 13.19 | 11 | 79908 | 67 | 31617358 |
Depressed mood | 33.25 | 13.19 | 3 | 79916 | 17572 | 31599853 |
Myocardial infarction | 33.19 | 13.19 | 160 | 79759 | 113294 | 31504131 |
Empyema | 32.95 | 13.19 | 39 | 79880 | 2922 | 31614503 |
Acquired gene mutation | 32.85 | 13.19 | 27 | 79892 | 1293 | 31616132 |
Oedema peripheral | 32.66 | 13.19 | 154 | 79765 | 109685 | 31507740 |
Nasal congestion | 32.51 | 13.19 | 6 | 79913 | 20375 | 31597050 |
Chloroma | 32.51 | 13.19 | 19 | 79900 | 519 | 31616906 |
Palmar-plantar erythrodysaesthesia syndrome | 32.19 | 13.19 | 99 | 79820 | 15384 | 31602041 |
Blood glucose increased | 32.13 | 13.19 | 66 | 79853 | 61017 | 31556408 |
Chronic obstructive pulmonary disease | 32.06 | 13.19 | 40 | 79879 | 45126 | 31572299 |
Chest discomfort | 31.74 | 13.19 | 47 | 79872 | 49322 | 31568103 |
Recall phenomenon | 31.68 | 13.19 | 19 | 79900 | 545 | 31616880 |
Back pain | 31.60 | 13.19 | 155 | 79764 | 109258 | 31508167 |
Dyskinesia | 31.60 | 13.19 | 7 | 79912 | 20903 | 31596522 |
Progressive multifocal leukoencephalopathy | 31.57 | 13.19 | 71 | 79848 | 9142 | 31608283 |
Sedation | 31.54 | 13.19 | 5 | 79914 | 18960 | 31598465 |
Pulmonary toxicity | 31.47 | 13.19 | 52 | 79867 | 5325 | 31612100 |
Serotonin syndrome | 31.11 | 13.19 | 5 | 79914 | 18768 | 31598657 |
Bicytopenia | 31.01 | 13.19 | 32 | 79887 | 2057 | 31615368 |
Confusional state | 30.89 | 13.19 | 203 | 79716 | 133131 | 31484294 |
Contusion | 30.70 | 13.19 | 23 | 79896 | 33005 | 31584420 |
Mantle cell lymphoma recurrent | 30.24 | 13.19 | 18 | 79901 | 509 | 31616916 |
Bradycardia | 30.03 | 13.19 | 83 | 79836 | 69244 | 31548181 |
Erectile dysfunction | 29.97 | 13.19 | 6 | 79913 | 19229 | 31598196 |
Gout | 29.76 | 13.19 | 5 | 79914 | 18169 | 31599256 |
Osteosarcoma recurrent | 29.63 | 13.19 | 8 | 79911 | 21 | 31617404 |
Blood HIV RNA increased | 29.61 | 13.19 | 24 | 79895 | 1127 | 31616298 |
Nephrolithiasis | 29.58 | 13.19 | 16 | 79903 | 27323 | 31590102 |
Papillary thyroid cancer | 29.58 | 13.19 | 19 | 79900 | 617 | 31616808 |
Toxicity to various agents | 29.42 | 13.19 | 304 | 79615 | 181183 | 31436242 |
Hyperammonaemic encephalopathy | 29.32 | 13.19 | 32 | 79887 | 2194 | 31615231 |
Pharyngeal inflammation | 29.17 | 13.19 | 15 | 79904 | 316 | 31617109 |
Injury | 28.98 | 13.19 | 7 | 79912 | 19702 | 31597723 |
Primitive neuroectodermal tumour | 28.76 | 13.19 | 10 | 79909 | 74 | 31617351 |
Malaise | 28.66 | 13.19 | 279 | 79640 | 168232 | 31449193 |
Blood creatinine increased | 28.64 | 13.19 | 347 | 79572 | 88731 | 31528694 |
Arterial occlusive disease | 28.57 | 13.19 | 43 | 79876 | 4066 | 31613359 |
Liver function test abnormal | 28.48 | 13.19 | 20 | 79899 | 29672 | 31587753 |
Radiation injury | 28.46 | 13.19 | 17 | 79902 | 484 | 31616941 |
Pancreatitis | 28.31 | 13.19 | 29 | 79890 | 35742 | 31581683 |
Disseminated intravascular coagulation | 27.77 | 13.19 | 114 | 79805 | 20423 | 31597002 |
Gait inability | 27.76 | 13.19 | 7 | 79912 | 19137 | 31598288 |
Drug resistance | 27.73 | 13.19 | 125 | 79794 | 23328 | 31594097 |
Sleep disorder | 27.67 | 13.19 | 16 | 79903 | 26332 | 31591093 |
Hepatic candidiasis | 27.49 | 13.19 | 9 | 79910 | 54 | 31617371 |
Peritonitis | 27.34 | 13.19 | 93 | 79826 | 15234 | 31602191 |
Metastatic gastric cancer | 27.25 | 13.19 | 12 | 79907 | 176 | 31617249 |
Abnormal behaviour | 27.19 | 13.19 | 13 | 79906 | 23815 | 31593610 |
Drug ineffective | 27.18 | 13.19 | 775 | 79144 | 394798 | 31222627 |
Plasma cell leukaemia | 26.97 | 13.19 | 21 | 79898 | 930 | 31616495 |
Cystitis haemorrhagic | 26.82 | 13.19 | 48 | 79871 | 5241 | 31612184 |
Sinusitis | 26.57 | 13.19 | 32 | 79887 | 36664 | 31580761 |
Extravasation | 26.43 | 13.19 | 27 | 79892 | 1715 | 31615710 |
Cytopenia | 26.33 | 13.19 | 74 | 79845 | 10936 | 31606489 |
Hypophosphataemia | 26.31 | 13.19 | 63 | 79856 | 8451 | 31608974 |
Fluid retention | 26.13 | 13.19 | 15 | 79904 | 24787 | 31592638 |
Flagellate dermatitis | 26.07 | 13.19 | 9 | 79910 | 65 | 31617360 |
Accidental overdose | 26.06 | 13.19 | 7 | 79912 | 18343 | 31599082 |
Enterocolitis | 25.99 | 13.19 | 57 | 79862 | 7217 | 31610208 |
Angina pectoris | 25.85 | 13.19 | 22 | 79897 | 29619 | 31587806 |
Non-small cell lung cancer | 25.77 | 13.19 | 41 | 79878 | 4068 | 31613357 |
Emotional distress | 25.73 | 13.19 | 3 | 79916 | 14353 | 31603072 |
Localised infection | 25.44 | 13.19 | 4 | 79915 | 15261 | 31602164 |
Product administration error | 25.40 | 13.19 | 4 | 79915 | 15243 | 31602182 |
Irritability | 25.35 | 13.19 | 13 | 79906 | 22876 | 31594549 |
Blindness cortical | 25.32 | 13.19 | 14 | 79905 | 343 | 31617082 |
Cerebral ischaemia | 25.17 | 13.19 | 50 | 79869 | 5905 | 31611520 |
Oral candidiasis | 25.08 | 13.19 | 73 | 79846 | 11004 | 31606421 |
Dermatitis acneiform | 25.08 | 13.19 | 49 | 79870 | 5718 | 31611707 |
Muscular weakness | 25.02 | 13.19 | 83 | 79836 | 65365 | 31552060 |
Diabetes mellitus | 25.00 | 13.19 | 43 | 79876 | 42513 | 31574912 |
Therapy cessation | 24.97 | 13.19 | 4 | 79915 | 15051 | 31602374 |
Agitation | 24.86 | 13.19 | 63 | 79856 | 54106 | 31563319 |
Blood cholesterol increased | 24.84 | 13.19 | 6 | 79913 | 16887 | 31600538 |
Blood pressure systolic increased | 24.83 | 13.19 | 9 | 79910 | 19461 | 31597964 |
Hepatitis B reactivation | 24.72 | 13.19 | 37 | 79882 | 3481 | 31613944 |
Adenocarcinoma gastric | 24.55 | 13.19 | 22 | 79897 | 1186 | 31616239 |
Cerebral venous sinus thrombosis | 24.53 | 13.19 | 15 | 79904 | 446 | 31616979 |
Pleural mesothelioma malignant | 24.45 | 13.19 | 9 | 79910 | 80 | 31617345 |
Refeeding syndrome | 24.32 | 13.19 | 7 | 79912 | 25 | 31617400 |
Neurotoxicity | 24.30 | 13.19 | 93 | 79826 | 16133 | 31601292 |
Superior mesenteric artery syndrome | 24.25 | 13.19 | 9 | 79910 | 82 | 31617343 |
EGFR gene mutation | 24.07 | 13.19 | 10 | 79909 | 126 | 31617299 |
Granulocyte count decreased | 24.06 | 13.19 | 17 | 79902 | 648 | 31616777 |
Testicular malignant teratoma | 24.05 | 13.19 | 6 | 79913 | 10 | 31617415 |
Lactic acidosis | 24.04 | 13.19 | 27 | 79892 | 31910 | 31585515 |
Gastrooesophageal reflux disease | 24.03 | 13.19 | 30 | 79889 | 33841 | 31583584 |
Lymphadenopathy mediastinal | 24.03 | 13.19 | 29 | 79890 | 2217 | 31615208 |
Cerebral infarction | 23.96 | 13.19 | 129 | 79790 | 25848 | 31591577 |
Cerebral venous thrombosis | 23.87 | 13.19 | 17 | 79902 | 656 | 31616769 |
Pneumothorax | 23.77 | 13.19 | 95 | 79824 | 16815 | 31600610 |
Road traffic accident | 23.74 | 13.19 | 6 | 79913 | 16375 | 31601050 |
Loss of personal independence in daily activities | 23.46 | 13.19 | 22 | 79897 | 28266 | 31589159 |
Small cell lung cancer | 23.14 | 13.19 | 26 | 79893 | 1841 | 31615584 |
Refractory cancer | 23.13 | 13.19 | 10 | 79909 | 140 | 31617285 |
Sleep apnoea syndrome | 23.10 | 13.19 | 9 | 79910 | 18616 | 31598809 |
Gene mutation | 23.05 | 13.19 | 21 | 79898 | 1157 | 31616268 |
Blood lactate dehydrogenase increased | 23 | 13.19 | 107 | 79812 | 20232 | 31597193 |
Labelled drug-drug interaction medication error | 22.98 | 13.19 | 3 | 79916 | 13160 | 31604265 |
Retinal toxicity | 22.84 | 13.19 | 14 | 79905 | 418 | 31617007 |
Haematochezia | 22.77 | 13.19 | 42 | 79877 | 40422 | 31577003 |
Arteriospasm coronary | 22.63 | 13.19 | 32 | 79887 | 2859 | 31614566 |
Diaphragm muscle weakness | 22.63 | 13.19 | 10 | 79909 | 148 | 31617277 |
Diffuse large B-cell lymphoma | 22.58 | 13.19 | 60 | 79859 | 8581 | 31608844 |
Myoclonus | 22.57 | 13.19 | 4 | 79915 | 13986 | 31603439 |
Procedural vomiting | 22.51 | 13.19 | 10 | 79909 | 150 | 31617275 |
Wound | 22.44 | 13.19 | 3 | 79916 | 12925 | 31604500 |
Paraneoplastic syndrome | 22.43 | 13.19 | 15 | 79904 | 522 | 31616903 |
Necrosis | 22.30 | 13.19 | 44 | 79875 | 5172 | 31612253 |
Metastases to peritoneum | 22.10 | 13.19 | 24 | 79895 | 1636 | 31615789 |
Oesophageal perforation | 22.06 | 13.19 | 19 | 79900 | 971 | 31616454 |
Granulocyte-colony stimulating factor level increased | 22.00 | 13.19 | 5 | 79914 | 4 | 31617421 |
Lung adenocarcinoma | 22.00 | 13.19 | 40 | 79879 | 4422 | 31613003 |
Procedural nausea | 21.94 | 13.19 | 8 | 79911 | 69 | 31617356 |
Embolism arterial | 21.88 | 13.19 | 15 | 79904 | 544 | 31616881 |
Morphoea | 21.87 | 13.19 | 10 | 79909 | 161 | 31617264 |
Hypochloraemia | 21.69 | 13.19 | 15 | 79904 | 552 | 31616873 |
Cholelithiasis | 21.66 | 13.19 | 11 | 79908 | 19468 | 31597957 |
Gastrointestinal ischaemia | 21.60 | 13.19 | 10 | 79909 | 166 | 31617259 |
Necrosis ischaemic | 21.51 | 13.19 | 11 | 79908 | 229 | 31617196 |
Hot flush | 21.50 | 13.19 | 7 | 79912 | 16189 | 31601236 |
Polyneuropathy | 21.48 | 13.19 | 77 | 79842 | 12945 | 31604480 |
Psychotic disorder | 21.40 | 13.19 | 15 | 79904 | 22278 | 31595147 |
Blood glucose decreased | 21.40 | 13.19 | 3 | 79916 | 12468 | 31604957 |
Deafness bilateral | 21.36 | 13.19 | 19 | 79900 | 1014 | 31616411 |
Pleural effusion | 21.17 | 13.19 | 285 | 79634 | 74635 | 31542790 |
Coronary artery thrombosis | 21.14 | 13.19 | 26 | 79893 | 2027 | 31615398 |
Tumour thrombosis | 21.08 | 13.19 | 8 | 79911 | 78 | 31617347 |
Herpes zoster | 21.01 | 13.19 | 30 | 79889 | 31963 | 31585462 |
Soft tissue disorder | 20.96 | 13.19 | 16 | 79903 | 688 | 31616737 |
Upper respiratory tract infection | 20.94 | 13.19 | 26 | 79893 | 29396 | 31588029 |
Hyperhidrosis | 20.90 | 13.19 | 93 | 79826 | 67300 | 31550125 |
Adenoviral hepatitis | 20.79 | 13.19 | 14 | 79905 | 493 | 31616932 |
Performance status decreased | 20.71 | 13.19 | 36 | 79883 | 3842 | 31613583 |
Mitral valve incompetence | 20.60 | 13.19 | 5 | 79914 | 14028 | 31603397 |
Immune-mediated dermatitis | 20.57 | 13.19 | 10 | 79909 | 186 | 31617239 |
Vascular injury | 20.37 | 13.19 | 11 | 79908 | 257 | 31617168 |
Metastases to skin | 20.27 | 13.19 | 13 | 79906 | 421 | 31617004 |
Neutrophil count abnormal | 20.13 | 13.19 | 23 | 79896 | 1659 | 31615766 |
Arteritis | 20.01 | 13.19 | 12 | 79907 | 344 | 31617081 |
Swelling | 19.95 | 13.19 | 40 | 79879 | 37318 | 31580107 |
Speech disorder | 19.86 | 13.19 | 19 | 79900 | 24182 | 31593243 |
Product quality issue | 19.63 | 13.19 | 8 | 79911 | 16103 | 31601322 |
Transient ischaemic attack | 19.61 | 13.19 | 19 | 79900 | 24037 | 31593388 |
Adrenocortical carcinoma | 19.58 | 13.19 | 6 | 79913 | 28 | 31617397 |
Failure to thrive | 19.52 | 13.19 | 54 | 79865 | 7908 | 31609517 |
Underdose | 19.50 | 13.19 | 4 | 79915 | 12603 | 31604822 |
Extremity necrosis | 19.46 | 13.19 | 23 | 79896 | 1720 | 31615705 |
Campylobacter test positive | 19.41 | 13.19 | 6 | 79913 | 29 | 31617396 |
Carotid artery dissection | 19.40 | 13.19 | 9 | 79910 | 150 | 31617275 |
Bronchitis | 19.38 | 13.19 | 43 | 79876 | 38674 | 31578751 |
Palpitations | 19.37 | 13.19 | 36 | 79883 | 34547 | 31582878 |
Loss of consciousness | 19.33 | 13.19 | 115 | 79804 | 77240 | 31540185 |
B-cell lymphoma refractory | 19.30 | 13.19 | 9 | 79910 | 152 | 31617273 |
Accidental exposure to product | 19.18 | 13.19 | 3 | 79916 | 11492 | 31605933 |
Disturbance in attention | 19.17 | 13.19 | 17 | 79902 | 22433 | 31594992 |
Transitional cell carcinoma recurrent | 19.14 | 13.19 | 5 | 79914 | 11 | 31617414 |
Cell-mediated immune deficiency | 19.08 | 13.19 | 6 | 79913 | 31 | 31617394 |
Peritoneal lesion | 19.03 | 13.19 | 8 | 79911 | 104 | 31617321 |
Visual impairment | 18.93 | 13.19 | 31 | 79888 | 31248 | 31586177 |
Full blood count decreased | 18.91 | 13.19 | 9 | 79910 | 16531 | 31600894 |
Laryngeal pain | 18.90 | 13.19 | 28 | 79891 | 2610 | 31614815 |
Hypoaesthesia | 18.80 | 13.19 | 75 | 79844 | 55947 | 31561478 |
Peripheral sensory neuropathy | 18.73 | 13.19 | 46 | 79873 | 6269 | 31611156 |
Iliac artery occlusion | 18.73 | 13.19 | 9 | 79910 | 163 | 31617262 |
Hyperlipidaemia | 18.72 | 13.19 | 5 | 79914 | 13155 | 31604270 |
Haematoma | 18.62 | 13.19 | 20 | 79899 | 24119 | 31593306 |
Medulloblastoma recurrent | 18.56 | 13.19 | 7 | 79912 | 67 | 31617358 |
Osteosarcoma metastatic | 18.56 | 13.19 | 5 | 79914 | 13 | 31617412 |
Metastases to chest wall | 18.53 | 13.19 | 9 | 79910 | 167 | 31617258 |
Gastrointestinal perforation | 18.47 | 13.19 | 33 | 79886 | 3599 | 31613826 |
Intestinal infarction | 18.43 | 13.19 | 13 | 79906 | 494 | 31616931 |
Seminoma | 18.42 | 13.19 | 10 | 79909 | 236 | 31617189 |
Transformation to acute myeloid leukaemia | 18.26 | 13.19 | 15 | 79904 | 718 | 31616707 |
Delusion | 18.16 | 13.19 | 4 | 79915 | 11993 | 31605432 |
Movement disorder | 18.11 | 13.19 | 3 | 79916 | 11016 | 31606409 |
Visceral venous thrombosis | 18.03 | 13.19 | 5 | 79914 | 15 | 31617410 |
Hypoalbuminaemia | 18.01 | 13.19 | 65 | 79854 | 10963 | 31606462 |
Injection site erythema | 17.92 | 13.19 | 7 | 79912 | 14455 | 31602970 |
Hepatic enzyme increased | 17.88 | 13.19 | 40 | 79879 | 35868 | 31581557 |
Burning sensation | 17.83 | 13.19 | 10 | 79909 | 16737 | 31600688 |
Urinary tract infection | 17.80 | 13.19 | 117 | 79802 | 76752 | 31540673 |
Metastases to bone | 17.77 | 13.19 | 64 | 79855 | 10784 | 31606641 |
Metastases to meninges | 17.68 | 13.19 | 19 | 79900 | 1280 | 31616145 |
Rectal haemorrhage | 17.62 | 13.19 | 41 | 79878 | 36263 | 31581162 |
Withdrawal syndrome | 17.55 | 13.19 | 4 | 79915 | 11713 | 31605712 |
Drug clearance decreased | 17.50 | 13.19 | 21 | 79898 | 1596 | 31615829 |
Pneumonia adenoviral | 17.49 | 13.19 | 11 | 79908 | 344 | 31617081 |
Dermatitis diaper | 17.31 | 13.19 | 10 | 79909 | 267 | 31617158 |
Swelling face | 17.31 | 13.19 | 17 | 79902 | 21373 | 31596052 |
Candida infection | 17.27 | 13.19 | 84 | 79835 | 16174 | 31601251 |
Drug intolerance | 17.24 | 13.19 | 70 | 79849 | 51963 | 31565462 |
Traumatic lung injury | 17.24 | 13.19 | 18 | 79901 | 1173 | 31616252 |
Meningitis tuberculous | 17.22 | 13.19 | 14 | 79905 | 660 | 31616765 |
Trigeminal nerve paresis | 17.18 | 13.19 | 4 | 79915 | 4 | 31617421 |
Spinal column injury | 17.17 | 13.19 | 13 | 79906 | 552 | 31616873 |
Oesophageal pain | 17.16 | 13.19 | 15 | 79904 | 782 | 31616643 |
BK virus infection | 17.16 | 13.19 | 39 | 79880 | 5056 | 31612369 |
Venous thrombosis | 17.10 | 13.19 | 30 | 79889 | 3225 | 31614200 |
Colitis ulcerative | 17.10 | 13.19 | 13 | 79906 | 18516 | 31598909 |
Gingivitis ulcerative | 17.07 | 13.19 | 6 | 79913 | 46 | 31617379 |
Fanconi syndrome | 17.04 | 13.19 | 21 | 79898 | 1641 | 31615784 |
Gastrointestinal anastomotic leak | 17.02 | 13.19 | 11 | 79908 | 361 | 31617064 |
Dementia | 17.02 | 13.19 | 5 | 79914 | 12355 | 31605070 |
Infected neoplasm | 17.01 | 13.19 | 7 | 79912 | 86 | 31617339 |
Chemotherapeutic drug level increased | 16.99 | 13.19 | 9 | 79910 | 202 | 31617223 |
Type 2 diabetes mellitus | 16.97 | 13.19 | 8 | 79911 | 14776 | 31602649 |
Blood creatinine | 16.96 | 13.19 | 6 | 79913 | 47 | 31617378 |
Human chorionic gonadotropin increased | 16.93 | 13.19 | 5 | 79914 | 20 | 31617405 |
Eye pain | 16.90 | 13.19 | 5 | 79914 | 12299 | 31605126 |
Hepatic steatosis | 16.85 | 13.19 | 10 | 79909 | 16229 | 31601196 |
Laryngeal inflammation | 16.74 | 13.19 | 5 | 79914 | 21 | 31617404 |
Immune-mediated hepatic disorder | 16.65 | 13.19 | 13 | 79906 | 578 | 31616847 |
Chondrosarcoma | 16.64 | 13.19 | 6 | 79913 | 50 | 31617375 |
Blister | 16.53 | 13.19 | 17 | 79902 | 20919 | 31596506 |
Haemoptysis | 16.44 | 13.19 | 138 | 79781 | 32051 | 31585374 |
Respiratory depression | 16.43 | 13.19 | 8 | 79911 | 14502 | 31602923 |
Subcutaneous emphysema | 16.42 | 13.19 | 17 | 79902 | 1097 | 31616328 |
Lymphangiosis carcinomatosa | 16.27 | 13.19 | 15 | 79904 | 839 | 31616586 |
Hypersomnia | 16.25 | 13.19 | 4 | 79915 | 11115 | 31606310 |
Dysstasia | 16.25 | 13.19 | 4 | 79915 | 11114 | 31606311 |
Frequent bowel movements | 16.18 | 13.19 | 3 | 79916 | 10156 | 31607269 |
Eosinophilia | 16.08 | 13.19 | 21 | 79898 | 23232 | 31594193 |
Treatment noncompliance | 15.97 | 13.19 | 25 | 79894 | 25659 | 31591766 |
Wound evisceration | 15.82 | 13.19 | 7 | 79912 | 104 | 31617321 |
Blood triglycerides increased | 15.77 | 13.19 | 7 | 79912 | 13390 | 31604035 |
Ureteric dilatation | 15.75 | 13.19 | 8 | 79911 | 164 | 31617261 |
Urine sodium increased | 15.68 | 13.19 | 6 | 79913 | 60 | 31617365 |
Rib fracture | 15.60 | 13.19 | 7 | 79912 | 13309 | 31604116 |
Ganglioneuroma | 15.57 | 13.19 | 4 | 79915 | 8 | 31617417 |
Extragonadal primary germ cell tumour mixed | 15.57 | 13.19 | 4 | 79915 | 8 | 31617417 |
Chromaturia | 15.57 | 13.19 | 7 | 79912 | 13291 | 31604134 |
Lymphadenopathy | 15.54 | 13.19 | 116 | 79803 | 26005 | 31591420 |
Myelitis transverse | 15.47 | 13.19 | 16 | 79903 | 1031 | 31616394 |
White blood cell disorder | 15.44 | 13.19 | 19 | 79900 | 1482 | 31615943 |
Testicular cancer metastatic | 15.42 | 13.19 | 6 | 79913 | 63 | 31617362 |
Mucosal toxicity | 15.39 | 13.19 | 9 | 79910 | 246 | 31617179 |
Agranulocytosis | 15.38 | 13.19 | 99 | 79820 | 21148 | 31596277 |
Choriocarcinoma | 15.27 | 13.19 | 5 | 79914 | 30 | 31617395 |
Nasal sinus cancer | 15.27 | 13.19 | 5 | 79914 | 30 | 31617395 |
Osteomyelitis | 15.22 | 13.19 | 9 | 79910 | 14634 | 31602791 |
Laboratory test abnormal | 15.17 | 13.19 | 15 | 79904 | 18799 | 31598626 |
Plasmacytoma | 15.06 | 13.19 | 29 | 79890 | 3348 | 31614077 |
Paranoia | 15.04 | 13.19 | 4 | 79915 | 10551 | 31606874 |
Head injury | 14.97 | 13.19 | 12 | 79907 | 16646 | 31600779 |
Pharyngeal stenosis | 14.96 | 13.19 | 3 | 79916 | 0 | 31617425 |
Carotid artery perforation | 14.96 | 13.19 | 3 | 79916 | 0 | 31617425 |
Salivary gland cancer recurrent | 14.96 | 13.19 | 3 | 79916 | 0 | 31617425 |
Evans syndrome | 14.80 | 13.19 | 9 | 79910 | 265 | 31617160 |
Gastrointestinal haemorrhage | 14.72 | 13.19 | 135 | 79784 | 82414 | 31535011 |
Seizure | 14.59 | 13.19 | 171 | 79748 | 99597 | 31517828 |
Bone sarcoma | 14.56 | 13.19 | 6 | 79913 | 74 | 31617351 |
Aortitis | 14.48 | 13.19 | 10 | 79909 | 367 | 31617058 |
Metapneumovirus bronchiolitis | 14.43 | 13.19 | 4 | 79915 | 12 | 31617413 |
Oesophageal squamous cell carcinoma | 14.32 | 13.19 | 10 | 79909 | 374 | 31617051 |
Subdural haematoma | 14.32 | 13.19 | 16 | 79903 | 18955 | 31598470 |
Thrombocytosis | 14.25 | 13.19 | 30 | 79889 | 3693 | 31613732 |
Illness | 14.23 | 13.19 | 3 | 79916 | 9274 | 31608151 |
Thrombotic thrombocytopenic purpura | 14.22 | 13.19 | 28 | 79891 | 3285 | 31614140 |
Subclavian vein thrombosis | 14.19 | 13.19 | 14 | 79905 | 853 | 31616572 |
Hip fracture | 14.14 | 13.19 | 5 | 79914 | 10981 | 31606444 |
Malocclusion | 14.14 | 13.19 | 6 | 79913 | 80 | 31617345 |
Hyperglycaemic hyperosmolar nonketotic syndrome | 14.13 | 13.19 | 16 | 79903 | 1143 | 31616282 |
Renal tubular necrosis | 14.09 | 13.19 | 74 | 79845 | 14685 | 31602740 |
Basal cell carcinoma | 14.09 | 13.19 | 15 | 79904 | 18164 | 31599261 |
JC virus infection | 14.05 | 13.19 | 21 | 79898 | 1973 | 31615452 |
Apparent mineralocorticoid excess | 14.04 | 13.19 | 5 | 79914 | 40 | 31617385 |
Eczema | 13.99 | 13.19 | 11 | 79908 | 15406 | 31602019 |
Viral load increased | 13.94 | 13.19 | 22 | 79897 | 2167 | 31615258 |
Blood magnesium decreased | 13.94 | 13.19 | 39 | 79880 | 5747 | 31611678 |
Limb injury | 13.94 | 13.19 | 4 | 79915 | 10037 | 31607388 |
Haemoperitoneum | 13.92 | 13.19 | 19 | 79900 | 1642 | 31615783 |
Tooth disorder | 13.91 | 13.19 | 4 | 79915 | 10025 | 31607400 |
Dropped head syndrome | 13.90 | 13.19 | 7 | 79912 | 141 | 31617284 |
Premature baby | 13.89 | 13.19 | 15 | 79904 | 18051 | 31599374 |
Cellulitis | 13.86 | 13.19 | 68 | 79851 | 47950 | 31569475 |
Platelet transfusion | 13.82 | 13.19 | 17 | 79902 | 1326 | 31616099 |
Retinopathy | 13.77 | 13.19 | 20 | 79899 | 1831 | 31615594 |
Cardiogenic shock | 13.76 | 13.19 | 22 | 79897 | 22386 | 31595039 |
Cerebrovascular accident | 13.74 | 13.19 | 131 | 79788 | 79353 | 31538072 |
Chronic hepatitis B | 13.73 | 13.19 | 5 | 79914 | 43 | 31617382 |
Enterococcal bacteraemia | 13.68 | 13.19 | 19 | 79900 | 1669 | 31615756 |
Dyspnoea exertional | 13.67 | 13.19 | 51 | 79868 | 38786 | 31578639 |
Therapeutic embolisation | 13.64 | 13.19 | 9 | 79910 | 306 | 31617119 |
Penile vein thrombosis | 13.55 | 13.19 | 4 | 79915 | 16 | 31617409 |
Torulopsis infection | 13.55 | 13.19 | 4 | 79915 | 16 | 31617409 |
Fistula of small intestine | 13.51 | 13.19 | 10 | 79909 | 410 | 31617015 |
Hypovolaemia | 13.38 | 13.19 | 49 | 79870 | 8323 | 31609102 |
Sarcoma | 13.34 | 13.19 | 10 | 79909 | 418 | 31617007 |
Focal nodular hyperplasia | 13.26 | 13.19 | 7 | 79912 | 156 | 31617269 |
Hemianopia | 13.25 | 13.19 | 12 | 79907 | 656 | 31616769 |
Heart rate irregular | 13.21 | 13.19 | 10 | 79909 | 14279 | 31603146 |
Alpha 1 foetoprotein increased | 13.20 | 13.19 | 12 | 79907 | 659 | 31616766 |
MedDRA adverse event term | Likelihood ratio | Likelihood ratio threshold | Patients taking drug having adverse event | Patients taking drug not having adverse event | Patients not taking drug having adverse event | Patients not taking drug not having adverse event |
---|---|---|---|---|---|---|
Febrile neutropenia | 2265.46 | 12.70 | 2198 | 115427 | 202120 | 70608699 |
Neutropenia | 1670.18 | 12.70 | 2090 | 115535 | 255066 | 70555753 |
Thrombocytopenia | 1206.35 | 12.70 | 1719 | 115906 | 237391 | 70573428 |
Mucosal inflammation | 1086.50 | 12.70 | 900 | 116725 | 66950 | 70743869 |
Malignant neoplasm progression | 1028.65 | 12.70 | 1134 | 116491 | 120605 | 70690214 |
Pancytopenia | 818.29 | 12.70 | 1125 | 116500 | 149982 | 70660837 |
Disease progression | 804.50 | 12.70 | 1137 | 116488 | 155535 | 70655284 |
Bone marrow failure | 773.68 | 12.70 | 645 | 116980 | 48365 | 70762454 |
Haematotoxicity | 680.71 | 12.70 | 368 | 117257 | 13306 | 70797513 |
Myelosuppression | 636.20 | 12.70 | 471 | 117154 | 29674 | 70781145 |
Anaemia | 560.83 | 12.70 | 1702 | 115923 | 401721 | 70409098 |
Leukopenia | 537.12 | 12.70 | 767 | 116858 | 105793 | 70705026 |
Acute myeloid leukaemia | 502.30 | 12.70 | 414 | 117211 | 30526 | 70780293 |
Dehydration | 477.29 | 12.70 | 1115 | 116510 | 225027 | 70585792 |
Arthralgia | 476.50 | 12.70 | 124 | 117501 | 503266 | 70307553 |
Vomiting | 457.43 | 12.70 | 2068 | 115557 | 591043 | 70219776 |
Rheumatoid arthritis | 440.02 | 12.70 | 9 | 117616 | 291796 | 70519023 |
Second primary malignancy | 413.23 | 12.70 | 262 | 117363 | 12789 | 70798030 |
Neutropenic sepsis | 351.23 | 12.70 | 307 | 117318 | 24523 | 70786296 |
Nausea | 347.97 | 12.70 | 2506 | 115119 | 849582 | 69961237 |
Neutrophil count decreased | 337.87 | 12.70 | 543 | 117082 | 83013 | 70727806 |
Off label use | 331.69 | 12.70 | 2234 | 115391 | 740826 | 70069993 |
Aortic thrombosis | 323.78 | 12.70 | 115 | 117510 | 1448 | 70809371 |
Ototoxicity | 318.24 | 12.70 | 135 | 117490 | 2806 | 70808013 |
Neoplasm progression | 315.25 | 12.70 | 382 | 117243 | 44846 | 70765973 |
Renal salt-wasting syndrome | 314.75 | 12.70 | 91 | 117534 | 552 | 70810267 |
Fall | 304.19 | 12.70 | 180 | 117445 | 443916 | 70366903 |
Joint swelling | 293.66 | 12.70 | 37 | 117588 | 253174 | 70557645 |
Nephropathy toxic | 272.12 | 12.70 | 234 | 117391 | 18280 | 70792539 |
Hypomagnesaemia | 269.07 | 12.70 | 335 | 117290 | 40429 | 70770390 |
Myelodysplastic syndrome | 267.65 | 12.70 | 287 | 117338 | 29498 | 70781321 |
Product dose omission issue | 259.01 | 12.70 | 29 | 117596 | 217439 | 70593380 |
Pulmonary embolism | 255.69 | 12.70 | 699 | 116926 | 155168 | 70655651 |
Acute kidney injury | 242.42 | 12.70 | 1478 | 116147 | 473146 | 70337673 |
Pain | 231.70 | 12.70 | 432 | 117193 | 628384 | 70182435 |
Therapy partial responder | 230.22 | 12.70 | 180 | 117445 | 12294 | 70798525 |
Pyrexia | 227.39 | 12.70 | 1751 | 115874 | 605201 | 70205618 |
Peripheral swelling | 225.83 | 12.70 | 57 | 117568 | 236506 | 70574313 |
Drug abuse | 224.00 | 12.70 | 4 | 117621 | 147252 | 70663567 |
Tumour lysis syndrome | 217.35 | 12.70 | 220 | 117405 | 21140 | 70789679 |
Cardiotoxicity | 209.21 | 12.70 | 162 | 117463 | 10908 | 70799911 |
Arthropathy | 206.95 | 12.70 | 10 | 117615 | 150047 | 70660772 |
Headache | 206.52 | 12.70 | 407 | 117218 | 579998 | 70230821 |
Diffuse large B-cell lymphoma recurrent | 205.54 | 12.70 | 105 | 117520 | 3371 | 70807448 |
Sepsis | 205.13 | 12.70 | 876 | 116749 | 243669 | 70567150 |
Platelet count decreased | 204.16 | 12.70 | 705 | 116920 | 177517 | 70633302 |
Metastases to lung | 203.88 | 12.70 | 189 | 117436 | 16295 | 70794524 |
Musculoskeletal stiffness | 203.29 | 12.70 | 10 | 117615 | 147750 | 70663069 |
Dysphagia | 203.19 | 12.70 | 524 | 117101 | 112310 | 70698509 |
Weight increased | 203.12 | 12.70 | 74 | 117551 | 242257 | 70568562 |
Deafness | 202.25 | 12.70 | 202 | 117423 | 19101 | 70791718 |
Metastases to central nervous system | 192.99 | 12.70 | 176 | 117449 | 14858 | 70795961 |
Decreased appetite | 189.50 | 12.70 | 1001 | 116624 | 303779 | 70507040 |
Nasopharyngitis | 184.28 | 12.70 | 69 | 117556 | 222137 | 70588682 |
Septic shock | 179.58 | 12.70 | 499 | 117126 | 111759 | 70699060 |
Posterior reversible encephalopathy syndrome | 174.73 | 12.70 | 209 | 117416 | 24193 | 70786626 |
Abdominal discomfort | 172.48 | 12.70 | 70 | 117555 | 214588 | 70596231 |
Drug hypersensitivity | 170.31 | 12.70 | 113 | 117512 | 262346 | 70548473 |
Anastomotic leak | 169.69 | 12.70 | 64 | 117561 | 965 | 70809854 |
Pain in extremity | 167.77 | 12.70 | 178 | 117447 | 327904 | 70482915 |
Hyponatraemia | 167.65 | 12.70 | 615 | 117010 | 159472 | 70651347 |
Therapeutic product effect decreased | 165.47 | 12.70 | 21 | 117604 | 142997 | 70667822 |
Hypokalaemia | 165.29 | 12.70 | 536 | 117089 | 130652 | 70680167 |
Teratoma | 163.37 | 12.70 | 42 | 117583 | 150 | 70810669 |
White blood cell count decreased | 161.15 | 12.70 | 633 | 116992 | 169508 | 70641311 |
Tinnitus | 158.46 | 12.70 | 244 | 117381 | 35932 | 70774887 |
Stomatitis | 153.79 | 12.70 | 516 | 117109 | 127995 | 70682824 |
Product use in unapproved indication | 151.17 | 12.70 | 713 | 116912 | 206765 | 70604054 |
Overdose | 150.60 | 12.70 | 47 | 117578 | 169698 | 70641121 |
Systemic lupus erythematosus | 150.13 | 12.70 | 4 | 117621 | 101898 | 70708921 |
Oesophagitis | 149.20 | 12.70 | 186 | 117439 | 22466 | 70788353 |
Asthma | 144.03 | 12.70 | 16 | 117609 | 120777 | 70690042 |
Renal failure | 143.80 | 12.70 | 658 | 116967 | 188412 | 70622407 |
Swelling | 142.71 | 12.70 | 67 | 117558 | 188472 | 70622347 |
Injection site pain | 141.71 | 12.70 | 15 | 117610 | 117604 | 70693215 |
Drug resistance | 140.54 | 12.70 | 238 | 117387 | 37952 | 70772867 |
Ovarian germ cell teratoma | 139.63 | 12.70 | 33 | 117592 | 74 | 70810745 |
Radiation skin injury | 139.00 | 12.70 | 60 | 117565 | 1303 | 70809516 |
Insomnia | 138.29 | 12.70 | 96 | 117529 | 217710 | 70593109 |
Pruritus | 137.29 | 12.70 | 226 | 117399 | 345334 | 70465485 |
Condition aggravated | 135.17 | 12.70 | 320 | 117305 | 427315 | 70383504 |
Diffuse large B-cell lymphoma refractory | 131.88 | 12.70 | 57 | 117568 | 1242 | 70809577 |
Neuropathy peripheral | 131.55 | 12.70 | 486 | 117139 | 126410 | 70684409 |
Psoriasis | 131.21 | 12.70 | 8 | 117617 | 98425 | 70712394 |
Oesophageal fistula | 130.93 | 12.70 | 41 | 117584 | 338 | 70810481 |
Inappropriate antidiuretic hormone secretion | 129.71 | 12.70 | 176 | 117449 | 23100 | 70787719 |
Metastases to liver | 128.31 | 12.70 | 185 | 117440 | 25693 | 70785126 |
Muscle spasms | 127.40 | 12.70 | 48 | 117577 | 153998 | 70656821 |
Gastrointestinal toxicity | 125.99 | 12.70 | 96 | 117529 | 6309 | 70804510 |
Contraindicated product administered | 125.40 | 12.70 | 34 | 117591 | 134578 | 70676241 |
Hypocalcaemia | 125.13 | 12.70 | 248 | 117377 | 44611 | 70766208 |
Arthritis | 124.71 | 12.70 | 10 | 117615 | 97970 | 70712849 |
Pemphigus | 123.30 | 12.70 | 3 | 117622 | 83033 | 70727786 |
Febrile bone marrow aplasia | 122.89 | 12.70 | 124 | 117501 | 11867 | 70798952 |
Osteosarcoma | 121.80 | 12.70 | 40 | 117585 | 390 | 70810429 |
Hypophagia | 121.03 | 12.70 | 234 | 117391 | 41336 | 70769483 |
Wound | 120.47 | 12.70 | 12 | 117613 | 98720 | 70712099 |
Contusion | 119.91 | 12.70 | 32 | 117593 | 128004 | 70682815 |
Renal impairment | 118.50 | 12.70 | 513 | 117112 | 143424 | 70667395 |
Peripheral artery thrombosis | 118.33 | 12.70 | 71 | 117554 | 3136 | 70807683 |
Metastases to lymph nodes | 116.33 | 12.70 | 107 | 117518 | 9131 | 70801688 |
Disease recurrence | 112.33 | 12.70 | 214 | 117411 | 37389 | 70773430 |
Depression | 112.01 | 12.70 | 99 | 117526 | 198875 | 70611944 |
Sinusitis | 110.84 | 12.70 | 72 | 117553 | 169123 | 70641696 |
Aorto-oesophageal fistula | 110.73 | 12.70 | 26 | 117599 | 56 | 70810763 |
Intentional product misuse | 107.52 | 12.70 | 6 | 117619 | 79589 | 70731230 |
Gastric perforation | 107.02 | 12.70 | 71 | 117554 | 3744 | 70807075 |
Deep vein thrombosis | 105.77 | 12.70 | 414 | 117211 | 110628 | 70700191 |
Palmar-plantar erythrodysaesthesia syndrome | 105.38 | 12.70 | 184 | 117441 | 30063 | 70780756 |
Leukoencephalopathy | 104.76 | 12.70 | 91 | 117534 | 7203 | 70803616 |
Renal tubular disorder | 103.82 | 12.70 | 84 | 117541 | 6026 | 70804793 |
Neurotoxicity | 103.35 | 12.70 | 181 | 117444 | 29645 | 70781174 |
Pneumonitis | 98.66 | 12.70 | 254 | 117371 | 54343 | 70756476 |
Blister | 98.24 | 12.70 | 23 | 117602 | 100503 | 70710316 |
Peripheral ischaemia | 97.97 | 12.70 | 95 | 117530 | 8663 | 70802156 |
Venoocclusive liver disease | 97.86 | 12.70 | 104 | 117521 | 10574 | 70800245 |
Mobility decreased | 97.86 | 12.70 | 25 | 117600 | 102974 | 70707845 |
Anxiety | 96.20 | 12.70 | 135 | 117490 | 220195 | 70590624 |
Osteoarthritis | 95.96 | 12.70 | 7 | 117618 | 74140 | 70736679 |
Rash | 94.85 | 12.70 | 480 | 117145 | 510082 | 70300737 |
Odynophagia | 94.84 | 12.70 | 100 | 117525 | 10075 | 70800744 |
Hepatic enzyme increased | 93.41 | 12.70 | 74 | 117551 | 156916 | 70653903 |
Dizziness | 92.21 | 12.70 | 426 | 117199 | 463715 | 70347104 |
Suicidal ideation | 91.73 | 12.70 | 6 | 117619 | 69590 | 70741229 |
Arterial thrombosis | 91.43 | 12.70 | 55 | 117570 | 2441 | 70808378 |
Urticaria | 90.71 | 12.70 | 82 | 117543 | 162967 | 70647852 |
Migraine | 90.20 | 12.70 | 8 | 117617 | 72230 | 70738589 |
Hypoacusis | 89.99 | 12.70 | 162 | 117463 | 27107 | 70783712 |
Hiccups | 89.83 | 12.70 | 92 | 117533 | 8960 | 70801859 |
Gait disturbance | 89.50 | 12.70 | 105 | 117520 | 185001 | 70625818 |
Electrolyte imbalance | 89.19 | 12.70 | 160 | 117465 | 26701 | 70784118 |
Malignant transformation | 88.99 | 12.70 | 42 | 117583 | 1131 | 70809688 |
Dermatitis | 87.89 | 12.70 | 133 | 117492 | 19284 | 70791535 |
Drug intolerance | 87.33 | 12.70 | 150 | 117475 | 225537 | 70585282 |
Suicide attempt | 86.52 | 12.70 | 14 | 117611 | 79496 | 70731323 |
Radiation pneumonitis | 85.35 | 12.70 | 61 | 117564 | 3632 | 70807187 |
Discomfort | 85.26 | 12.70 | 34 | 117591 | 105402 | 70705417 |
Hospitalisation | 84.52 | 12.70 | 17 | 117608 | 82551 | 70728268 |
Drug interaction | 84.36 | 12.70 | 336 | 117289 | 381105 | 70429714 |
Blood pressure increased | 83.79 | 12.70 | 114 | 117511 | 188403 | 70622416 |
Wheezing | 83.63 | 12.70 | 26 | 117599 | 94144 | 70716675 |
Osteoradionecrosis | 83.03 | 12.70 | 22 | 117603 | 91 | 70810728 |
Urogenital fistula | 82.14 | 12.70 | 23 | 117602 | 122 | 70810697 |
Feeling abnormal | 81.06 | 12.70 | 70 | 117555 | 142249 | 70668570 |
Stress | 81.01 | 12.70 | 9 | 117616 | 67957 | 70742862 |
Bacteraemia | 80.49 | 12.70 | 161 | 117464 | 29148 | 70781671 |
Teratoma benign | 80.20 | 12.70 | 20 | 117605 | 61 | 70810758 |
Bronchitis | 77.99 | 12.70 | 49 | 117576 | 117194 | 70693625 |
Recall phenomenon | 77.53 | 12.70 | 37 | 117588 | 1022 | 70809797 |
Nasal congestion | 77.51 | 12.70 | 9 | 117616 | 65663 | 70745156 |
Injury | 76.86 | 12.70 | 9 | 117616 | 65236 | 70745583 |
Myalgia | 76.16 | 12.70 | 100 | 117525 | 167792 | 70643027 |
Enteritis | 76.05 | 12.70 | 100 | 117525 | 12731 | 70798088 |
Acute respiratory distress syndrome | 75.64 | 12.70 | 193 | 117432 | 41061 | 70769758 |
Blood creatinine increased | 75.60 | 12.70 | 450 | 117175 | 142551 | 70668268 |
Injection site erythema | 74.67 | 12.70 | 15 | 117610 | 72909 | 70737910 |
Balance disorder | 74.63 | 12.70 | 28 | 117597 | 90100 | 70720719 |
Inappropriate schedule of product administration | 74.27 | 12.70 | 43 | 117582 | 107512 | 70703307 |
Thrombotic microangiopathy | 73.44 | 12.70 | 117 | 117508 | 17731 | 70793088 |
Infusion related reaction | 72.18 | 12.70 | 136 | 117489 | 197398 | 70613421 |
Bicytopenia | 71.90 | 12.70 | 57 | 117568 | 3971 | 70806848 |
Colitis | 71.69 | 12.70 | 251 | 117374 | 63563 | 70747256 |
Diarrhoea | 71.39 | 12.70 | 1750 | 115875 | 781591 | 70029228 |
Somnolence | 70.69 | 12.70 | 158 | 117467 | 215448 | 70595371 |
Deafness bilateral | 70.58 | 12.70 | 43 | 117582 | 1953 | 70808866 |
Large intestine perforation | 69.34 | 12.70 | 97 | 117528 | 13098 | 70797721 |
Loss of personal independence in daily activities | 69.27 | 12.70 | 27 | 117598 | 84883 | 70725936 |
Pulmonary vascular disorder | 68.83 | 12.70 | 33 | 117592 | 921 | 70809898 |
Radiation oesophagitis | 68.70 | 12.70 | 29 | 117596 | 595 | 70810224 |
Drug ineffective | 68.27 | 12.70 | 1123 | 116502 | 938629 | 69872190 |
Rhabdomyolysis | 67.97 | 12.70 | 37 | 117588 | 95723 | 70715096 |
Respiratory failure | 67.94 | 12.70 | 496 | 117129 | 168239 | 70642580 |
Aplasia | 67.12 | 12.70 | 71 | 117554 | 7180 | 70803639 |
Fibromyalgia | 66.59 | 12.70 | 3 | 117622 | 47871 | 70762948 |
Wrong technique in product usage process | 66.56 | 12.70 | 16 | 117609 | 68682 | 70742137 |
Chloroma | 66.02 | 12.70 | 30 | 117595 | 739 | 70810080 |
Influenza | 65.87 | 12.70 | 55 | 117570 | 113645 | 70697174 |
Hepatitis B | 65.62 | 12.70 | 74 | 117551 | 8040 | 70802779 |
Cardiomyopathy | 65.50 | 12.70 | 139 | 117486 | 26234 | 70784585 |
Plasma cell leukaemia | 65.37 | 12.70 | 40 | 117585 | 1831 | 70808988 |
Cardiac failure congestive | 65.29 | 12.70 | 77 | 117548 | 135380 | 70675439 |
Pleural effusion | 65.10 | 12.70 | 410 | 117215 | 132454 | 70678365 |
Blood pressure fluctuation | 65.09 | 12.70 | 10 | 117615 | 59002 | 70751817 |
Deafness neurosensory | 65.08 | 12.70 | 67 | 117558 | 6565 | 70804254 |
Neutropenic colitis | 63.94 | 12.70 | 59 | 117566 | 5055 | 70805764 |
Influenza like illness | 63.72 | 12.70 | 15 | 117610 | 65316 | 70745503 |
Osteosarcoma metastatic | 62.71 | 12.70 | 16 | 117609 | 55 | 70810764 |
Bacterial translocation | 62.67 | 12.70 | 26 | 117599 | 510 | 70810309 |
Metastasis | 62.24 | 12.70 | 63 | 117562 | 6051 | 70804768 |
Cystitis haemorrhagic | 62.17 | 12.70 | 74 | 117551 | 8519 | 70802300 |
Radiation injury | 62.13 | 12.70 | 29 | 117596 | 761 | 70810058 |
Renal tubular necrosis | 62.09 | 12.70 | 126 | 117499 | 23045 | 70787774 |
Bronchial fistula | 61.84 | 12.70 | 20 | 117605 | 185 | 70810634 |
Cytomegalovirus oesophagitis | 61.83 | 12.70 | 28 | 117597 | 684 | 70810135 |
Oesophageal stenosis | 61.67 | 12.70 | 52 | 117573 | 3952 | 70806867 |
Portal venous gas | 60.85 | 12.70 | 23 | 117602 | 349 | 70810470 |
Exposure during pregnancy | 60.66 | 12.70 | 35 | 117590 | 87682 | 70723137 |
Atypical haemolytic uraemic syndrome | 60.50 | 12.70 | 29 | 117596 | 809 | 70810010 |
Salivary gland cancer | 60.05 | 12.70 | 24 | 117601 | 426 | 70810393 |
Injection site swelling | 59.07 | 12.70 | 3 | 117622 | 43154 | 70767665 |
Oesophagobronchial fistula | 59.07 | 12.70 | 20 | 117605 | 216 | 70810603 |
Hypophosphataemia | 59.07 | 12.70 | 101 | 117524 | 16225 | 70794594 |
Heart rate decreased | 59.00 | 12.70 | 15 | 117610 | 62000 | 70748819 |
Blood cholesterol increased | 58.88 | 12.70 | 17 | 117608 | 64587 | 70746232 |
Acquired gene mutation | 58.74 | 12.70 | 39 | 117586 | 2059 | 70808760 |
Metastases to skin | 58.53 | 12.70 | 35 | 117590 | 1536 | 70809283 |
Maternal exposure during pregnancy | 58.39 | 12.70 | 63 | 117562 | 115282 | 70695537 |
Metastases to bone | 57.98 | 12.70 | 120 | 117505 | 22256 | 70788563 |
Osteoporosis | 56.98 | 12.70 | 7 | 117618 | 48900 | 70761919 |
Polyneuropathy | 56.85 | 12.70 | 116 | 117509 | 21299 | 70789520 |
Disseminated intravascular coagulation | 56.30 | 12.70 | 152 | 117473 | 33446 | 70777373 |
Embolism | 56.01 | 12.70 | 87 | 117538 | 12901 | 70797918 |
Cataract | 55.83 | 12.70 | 12 | 117613 | 55633 | 70755186 |
Metastases to breast | 55.72 | 12.70 | 20 | 117605 | 260 | 70810559 |
Pulmonary arteriopathy | 55.63 | 12.70 | 16 | 117609 | 95 | 70810724 |
Vena cava thrombosis | 55.52 | 12.70 | 41 | 117584 | 2569 | 70808250 |
Type 2 diabetes mellitus | 54.71 | 12.70 | 5 | 117620 | 44075 | 70766744 |
Drug clearance decreased | 54.56 | 12.70 | 43 | 117582 | 2970 | 70807849 |
Splenic infarction | 54.51 | 12.70 | 45 | 117580 | 3321 | 70807498 |
Electrocardiogram QT prolonged | 54.04 | 12.70 | 36 | 117589 | 83481 | 70727338 |
Malaise | 53.46 | 12.70 | 460 | 117165 | 432472 | 70378347 |
Memory impairment | 53.43 | 12.70 | 45 | 117580 | 92596 | 70718223 |
Hypoglycaemia | 53.01 | 12.70 | 47 | 117578 | 94317 | 70716502 |
Tumour haemorrhage | 52.57 | 12.70 | 46 | 117579 | 3676 | 70807143 |
Vision blurred | 52.53 | 12.70 | 48 | 117577 | 94936 | 70715883 |
Interstitial lung disease | 52.49 | 12.70 | 325 | 117300 | 104360 | 70706459 |
Tumour necrosis | 52.28 | 12.70 | 34 | 117591 | 1733 | 70809086 |
Cytopenia | 52.24 | 12.70 | 99 | 117526 | 17224 | 70793595 |
Ameloblastoma | 52.16 | 12.70 | 15 | 117610 | 89 | 70810730 |
Renal infarct | 52.06 | 12.70 | 39 | 117586 | 2498 | 70808321 |
Lung adenocarcinoma | 52.00 | 12.70 | 64 | 117561 | 7626 | 70803193 |
Serotonin syndrome | 51.67 | 12.70 | 5 | 117620 | 42109 | 70768710 |
Empyema | 50.85 | 12.70 | 46 | 117579 | 3841 | 70806978 |
Adverse drug reaction | 50.56 | 12.70 | 13 | 117612 | 53331 | 70757488 |
Fatigue | 50.04 | 12.70 | 1016 | 116609 | 823303 | 69987516 |
Small cell lung cancer | 49.96 | 12.70 | 40 | 117585 | 2826 | 70807993 |
Anastomotic complication | 49.78 | 12.70 | 21 | 117604 | 430 | 70810389 |
Gastrointestinal perforation | 49.72 | 12.70 | 54 | 117571 | 5627 | 70805192 |
Peritonitis | 49.64 | 12.70 | 124 | 117501 | 26035 | 70784784 |
Sedation | 49.14 | 12.70 | 9 | 117616 | 46722 | 70764097 |
Red blood cell sedimentation rate increased | 49.00 | 12.70 | 4 | 117621 | 38638 | 70772181 |
Gastrooesophageal reflux disease | 48.95 | 12.70 | 47 | 117578 | 90792 | 70720027 |
Cerebral infarction | 48.15 | 12.70 | 169 | 117456 | 42840 | 70767979 |
Lymphopenia | 48.10 | 12.70 | 126 | 117499 | 27233 | 70783586 |
Cerebral venous thrombosis | 47.94 | 12.70 | 37 | 117588 | 2478 | 70808341 |
General physical health deterioration | 47.89 | 12.70 | 600 | 117025 | 235431 | 70575388 |
Pericarditis | 47.81 | 12.70 | 42 | 117583 | 84663 | 70726156 |
Fluid retention | 47.19 | 12.70 | 23 | 117602 | 63362 | 70747457 |
Performance status decreased | 46.87 | 12.70 | 52 | 117573 | 5549 | 70805270 |
Mantle cell lymphoma recurrent | 46.45 | 12.70 | 21 | 117604 | 511 | 70810308 |
Neoplasm recurrence | 46.45 | 12.70 | 44 | 117581 | 3897 | 70806922 |
Tremor | 46.27 | 12.70 | 120 | 117505 | 155504 | 70655315 |
COVID-19 | 45.92 | 12.70 | 65 | 117560 | 105692 | 70705127 |
Arteriospasm coronary | 45.44 | 12.70 | 53 | 117572 | 5971 | 70804848 |
Adrenocortical carcinoma | 45.37 | 12.70 | 13 | 117612 | 76 | 70810743 |
Sleep disorder | 45.37 | 12.70 | 30 | 117595 | 69842 | 70740977 |
Blood sodium decreased | 44.86 | 12.70 | 133 | 117492 | 30865 | 70779954 |
Back pain | 44.69 | 12.70 | 265 | 117360 | 270887 | 70539932 |
Hypoaesthesia | 44.60 | 12.70 | 120 | 117505 | 153619 | 70657200 |
B-cell lymphoma recurrent | 44.56 | 12.70 | 24 | 117601 | 860 | 70809959 |
Blood creatine phosphokinase increased | 44.46 | 12.70 | 23 | 117602 | 61240 | 70749579 |
Oedema peripheral | 44.21 | 12.70 | 211 | 117414 | 227880 | 70582939 |
Duodenal ulcer perforation | 43.81 | 12.70 | 15 | 117610 | 51097 | 70759722 |
Aggression | 43.68 | 12.70 | 13 | 117612 | 48433 | 70762386 |
Tumour perforation | 43.62 | 12.70 | 18 | 117607 | 348 | 70810471 |
Pulmonary toxicity | 43.35 | 12.70 | 70 | 117555 | 10728 | 70800091 |
Blood stem cell transplant failure | 43.20 | 12.70 | 20 | 117605 | 515 | 70810304 |
Incorrect dose administered | 42.84 | 12.70 | 29 | 117596 | 66690 | 70744129 |
Burning sensation | 42.81 | 12.70 | 17 | 117608 | 52853 | 70757966 |
Drug withdrawal syndrome | 42.58 | 12.70 | 3 | 117622 | 32712 | 70778107 |
Necrosis | 42.03 | 12.70 | 61 | 117564 | 8520 | 70802299 |
Dermatitis acneiform | 41.52 | 12.70 | 62 | 117563 | 8883 | 70801936 |
Pneumatosis intestinalis | 41.44 | 12.70 | 50 | 117575 | 5837 | 70804982 |
Extremity necrosis | 41.13 | 12.70 | 36 | 117589 | 2878 | 70807941 |
Cardiac disorder | 40.66 | 12.70 | 24 | 117601 | 59391 | 70751428 |
Coronary artery disease | 40.64 | 12.70 | 27 | 117598 | 62709 | 70748110 |
Hallucination | 40.45 | 12.70 | 40 | 117585 | 76220 | 70734599 |
Intestinal ischaemia | 40.22 | 12.70 | 72 | 117553 | 11992 | 70798827 |
Radiation mucositis | 40.21 | 12.70 | 15 | 117610 | 219 | 70810600 |
Nervousness | 40.08 | 12.70 | 3 | 117622 | 31117 | 70779702 |
Metastases to peritoneum | 40.06 | 12.70 | 40 | 117585 | 3779 | 70807040 |
Palpitations | 39.78 | 12.70 | 77 | 117548 | 110676 | 70700143 |
Pneumothorax | 39.43 | 12.70 | 113 | 117512 | 25733 | 70785086 |
Blood pressure systolic increased | 39.37 | 12.70 | 23 | 117602 | 57236 | 70753583 |
Refeeding syndrome | 39.03 | 12.70 | 11 | 117614 | 60 | 70810759 |
Heart rate increased | 38.82 | 12.70 | 73 | 117552 | 106075 | 70704744 |
Injection site reaction | 38.80 | 12.70 | 17 | 117608 | 49835 | 70760984 |
Hypoalbuminaemia | 38.79 | 12.70 | 93 | 117532 | 19029 | 70791790 |
Chronic obstructive pulmonary disease | 38.63 | 12.70 | 43 | 117582 | 77598 | 70733221 |
Lactic acidosis | 38.21 | 12.70 | 31 | 117594 | 64993 | 70745826 |
Testicular germ cell cancer metastatic | 38.14 | 12.70 | 11 | 117614 | 66 | 70810753 |
Road traffic accident | 37.97 | 12.70 | 6 | 117619 | 34676 | 70776143 |
Confusional state | 37.88 | 12.70 | 296 | 117329 | 284102 | 70526717 |
Product prescribing error | 37.87 | 12.70 | 9 | 117616 | 38943 | 70771876 |
Angioedema | 37.62 | 12.70 | 33 | 117592 | 66577 | 70744242 |
Hydronephrosis | 37.46 | 12.70 | 80 | 117545 | 15162 | 70795657 |
Product use issue | 36.92 | 12.70 | 163 | 117462 | 179774 | 70631045 |
Blood lactate dehydrogenase increased | 36.74 | 12.70 | 135 | 117490 | 34992 | 70775827 |
Osteosarcoma recurrent | 36.71 | 12.70 | 10 | 117615 | 47 | 70810772 |
Lower respiratory tract infection | 36.66 | 12.70 | 82 | 117543 | 111831 | 70698988 |
Diffuse large B-cell lymphoma | 36.43 | 12.70 | 73 | 117552 | 13229 | 70797590 |
Plasmacytoma | 36.29 | 12.70 | 39 | 117586 | 4015 | 70806804 |
Gastrointestinal anastomotic leak | 36.18 | 12.70 | 17 | 117608 | 453 | 70810366 |
Gastrointestinal fungal infection | 36.06 | 12.70 | 16 | 117609 | 372 | 70810447 |
Cerebral ischaemia | 35.82 | 12.70 | 63 | 117562 | 10349 | 70800470 |
Localised infection | 35.71 | 12.70 | 6 | 117619 | 33152 | 70777667 |
Unevaluable event | 35.67 | 12.70 | 21 | 117604 | 52042 | 70758777 |
Hypersensitivity | 35.06 | 12.70 | 230 | 117395 | 229582 | 70581237 |
Peripheral sensory neuropathy | 35.03 | 12.70 | 68 | 117557 | 12042 | 70798777 |
Myasthenia gravis crisis | 33.95 | 12.70 | 21 | 117604 | 980 | 70809839 |
Gait inability | 33.80 | 12.70 | 18 | 117607 | 47157 | 70763662 |
Large intestinal ulcer perforation | 33.74 | 12.70 | 10 | 117615 | 67 | 70810752 |
Muscular weakness | 33.68 | 12.70 | 117 | 117508 | 138219 | 70672600 |
Neurosensory hypoacusis | 33.59 | 12.70 | 13 | 117612 | 211 | 70810608 |
Fanconi syndrome | 33.34 | 12.70 | 31 | 117594 | 2682 | 70808137 |
Ureteric rupture | 32.99 | 12.70 | 7 | 117618 | 7 | 70810812 |
Coronary artery thrombosis | 32.95 | 12.70 | 32 | 117593 | 2923 | 70807896 |
Blindness cortical | 32.93 | 12.70 | 20 | 117605 | 903 | 70809916 |
Eye pain | 32.92 | 12.70 | 8 | 117617 | 34094 | 70776725 |
Melanoderma | 32.92 | 12.70 | 15 | 117610 | 372 | 70810447 |
Abortion spontaneous | 32.87 | 12.70 | 3 | 117622 | 26476 | 70784343 |
Throat irritation | 32.70 | 12.70 | 9 | 117616 | 35295 | 70775524 |
Toxicity to various agents | 32.64 | 12.70 | 442 | 117183 | 381730 | 70429089 |
Joint stiffness | 32.52 | 12.70 | 9 | 117616 | 35167 | 70775652 |
Refractory cancer | 32.51 | 12.70 | 13 | 117612 | 231 | 70810588 |
Intestinal perforation | 32.51 | 12.70 | 78 | 117547 | 15966 | 70794853 |
Tumour thrombosis | 32.39 | 12.70 | 11 | 117614 | 120 | 70810699 |
Musculoskeletal pain | 32.26 | 12.70 | 63 | 117562 | 90264 | 70720555 |
Wernicke's encephalopathy | 32.18 | 12.70 | 8 | 117617 | 24 | 70810795 |
Acoustic stimulation tests abnormal | 32.18 | 12.70 | 8 | 117617 | 24 | 70810795 |
Impaired healing | 32.00 | 12.70 | 46 | 117579 | 74328 | 70736491 |
Cervix neoplasm | 31.99 | 12.70 | 12 | 117613 | 178 | 70810641 |
Gastric disorder | 31.81 | 12.70 | 8 | 117617 | 33314 | 70777505 |
Blood glucose increased | 31.69 | 12.70 | 78 | 117547 | 102904 | 70707915 |
Primitive neuroectodermal tumour | 31.50 | 12.70 | 9 | 117616 | 52 | 70810767 |
Mesenteric abscess | 31.44 | 12.70 | 11 | 117614 | 132 | 70810687 |
Irritability | 31.43 | 12.70 | 12 | 117613 | 38213 | 70772606 |
Injection site haemorrhage | 31.40 | 12.70 | 3 | 117622 | 25524 | 70785295 |
Metastases to meninges | 31.35 | 12.70 | 32 | 117593 | 3104 | 70807715 |
Malnutrition | 31.16 | 12.70 | 89 | 117536 | 20228 | 70790591 |
Multiple sclerosis | 31.03 | 12.70 | 3 | 117622 | 25282 | 70785537 |
Extravasation | 30.97 | 12.70 | 33 | 117592 | 3364 | 70807455 |
Non-small cell lung cancer | 30.91 | 12.70 | 45 | 117580 | 6302 | 70804517 |
Obesity | 30.78 | 12.70 | 4 | 117621 | 26767 | 70784052 |
Accidental exposure to product | 30.37 | 12.70 | 5 | 117620 | 28046 | 70782773 |
Nasal abscess | 30.37 | 12.70 | 11 | 117614 | 147 | 70810672 |
Product administration error | 30.37 | 12.70 | 6 | 117619 | 29517 | 70781302 |
Ascites | 30.34 | 12.70 | 204 | 117421 | 67343 | 70743476 |
Swelling face | 30.32 | 12.70 | 36 | 117589 | 63128 | 70747691 |
Seminoma | 30.23 | 12.70 | 12 | 117613 | 209 | 70810610 |
Underdose | 30.17 | 12.70 | 6 | 117619 | 29377 | 70781442 |
Myoclonus | 30.15 | 12.70 | 4 | 117621 | 26351 | 70784468 |
Chemical peritonitis | 30.13 | 12.70 | 13 | 117612 | 282 | 70810537 |
Candida infection | 29.98 | 12.70 | 125 | 117500 | 34348 | 70776471 |
Visceral venous thrombosis | 29.83 | 12.70 | 7 | 117618 | 15 | 70810804 |
Cholelithiasis | 29.83 | 12.70 | 21 | 117604 | 47319 | 70763500 |
Labelled drug-drug interaction medication error | 29.25 | 12.70 | 3 | 117622 | 24124 | 70786695 |
Limb injury | 29.24 | 12.70 | 4 | 117621 | 25748 | 70785071 |
Lip swelling | 29.17 | 12.70 | 10 | 117615 | 34044 | 70776775 |
Nephritis bacterial | 29.13 | 12.70 | 8 | 117617 | 39 | 70810780 |
Tracheal stenosis | 29.07 | 12.70 | 13 | 117612 | 308 | 70810511 |
Blood HIV RNA increased | 29 | 12.70 | 23 | 117602 | 1603 | 70809216 |
EGFR gene mutation | 29.00 | 12.70 | 14 | 117611 | 397 | 70810422 |
Dyskinesia | 28.95 | 12.70 | 16 | 117609 | 41058 | 70769761 |
Superior mesenteric artery syndrome | 28.86 | 12.70 | 11 | 117614 | 171 | 70810648 |
Hepatic steatosis | 28.84 | 12.70 | 10 | 117615 | 33803 | 70777016 |
Pregnancy | 28.72 | 12.70 | 3 | 117622 | 23778 | 70787041 |
Basal cell carcinoma | 28.69 | 12.70 | 10 | 117615 | 33688 | 70777131 |
Femur fracture | 28.63 | 12.70 | 12 | 117613 | 36120 | 70774699 |
Limb discomfort | 28.61 | 12.70 | 7 | 117618 | 29698 | 70781121 |
Emotional distress | 28.44 | 12.70 | 13 | 117612 | 37175 | 70773644 |
Progressive multifocal leukoencephalopathy | 28.34 | 12.70 | 83 | 117542 | 19131 | 70791688 |
Oesophageal perforation | 28.33 | 12.70 | 21 | 117604 | 1323 | 70809496 |
Flagellate dermatitis | 28.26 | 12.70 | 12 | 117613 | 250 | 70810569 |
International normalised ratio increased | 28.23 | 12.70 | 57 | 117568 | 80669 | 70730150 |
Hepatic candidiasis | 28.04 | 12.70 | 9 | 117616 | 81 | 70810738 |
Lymphadenopathy mediastinal | 27.90 | 12.70 | 34 | 117591 | 4011 | 70806808 |
Blood magnesium decreased | 27.79 | 12.70 | 70 | 117555 | 14771 | 70796048 |
Agitation | 27.74 | 12.70 | 72 | 117553 | 93303 | 70717516 |
Adenocarcinoma gastric | 27.68 | 12.70 | 23 | 117602 | 1713 | 70809106 |
Hepatitis B reactivation | 27.59 | 12.70 | 39 | 117586 | 5316 | 70805503 |
Neutrophil count abnormal | 27.58 | 12.70 | 30 | 117595 | 3131 | 70807688 |
Sciatica | 27.55 | 12.70 | 4 | 117621 | 24623 | 70786196 |
Metastases to adrenals | 27.53 | 12.70 | 20 | 117605 | 1222 | 70809597 |
Cerebellar haemangioma | 27.38 | 12.70 | 9 | 117616 | 88 | 70810731 |
Sleep apnoea syndrome | 27.35 | 12.70 | 10 | 117615 | 32703 | 70778116 |
Haematoma | 27.32 | 12.70 | 24 | 117601 | 48394 | 70762425 |
Herpes simplex encephalitis | 27.12 | 12.70 | 16 | 117609 | 685 | 70810134 |
Blood pressure diastolic decreased | 27.03 | 12.70 | 5 | 117620 | 25775 | 70785044 |
Therapy cessation | 26.98 | 12.70 | 11 | 117614 | 33665 | 70777154 |
Prescribed overdose | 26.98 | 12.70 | 6 | 117619 | 27175 | 70783644 |
Poisoning | 26.94 | 12.70 | 3 | 117622 | 22619 | 70788200 |
Urinary tract infection | 26.92 | 12.70 | 273 | 117352 | 248496 | 70562323 |
Upper respiratory tract infection | 26.85 | 12.70 | 57 | 117568 | 79217 | 70731602 |
Blood glucose decreased | 26.85 | 12.70 | 4 | 117621 | 24155 | 70786664 |
Failure to thrive | 26.80 | 12.70 | 57 | 117568 | 10772 | 70800047 |
Agranulocytosis | 26.77 | 12.70 | 135 | 117490 | 40163 | 70770656 |
Dry eye | 26.77 | 12.70 | 10 | 117615 | 32272 | 70778547 |
Ear infection | 26.67 | 12.70 | 7 | 117618 | 28329 | 70782490 |
Necrotising colitis | 26.66 | 12.70 | 18 | 117607 | 977 | 70809842 |
Device issue | 26.65 | 12.70 | 4 | 117621 | 24021 | 70786798 |
Metastatic gastric cancer | 26.63 | 12.70 | 13 | 117612 | 378 | 70810441 |
Myocardial infarction | 26.56 | 12.70 | 171 | 117454 | 171474 | 70639345 |
Testicular malignant teratoma | 26.55 | 12.70 | 6 | 117619 | 10 | 70810809 |
Cholangitis | 26.54 | 12.70 | 59 | 117566 | 11490 | 70799329 |
Cerebral venous sinus thrombosis | 26.50 | 12.70 | 24 | 117601 | 2007 | 70808812 |
Hyperhidrosis | 26.50 | 12.70 | 120 | 117505 | 131466 | 70679353 |
Papillary thyroid cancer | 26.42 | 12.70 | 26 | 117599 | 2414 | 70808405 |
Right ventricular failure | 26.41 | 12.70 | 3 | 117622 | 22271 | 70788548 |
Choriocarcinoma | 26.26 | 12.70 | 10 | 117615 | 155 | 70810664 |
Erythropenia | 26.01 | 12.70 | 13 | 117612 | 398 | 70810421 |
Plasma cell myeloma | 25.98 | 12.70 | 209 | 117416 | 72992 | 70737827 |
Enterocolitis | 25.92 | 12.70 | 63 | 117562 | 13003 | 70797816 |
Alpha 1 foetoprotein increased | 25.82 | 12.70 | 16 | 117609 | 749 | 70810070 |
Traumatic lung injury | 25.77 | 12.70 | 25 | 117600 | 2280 | 70808539 |
BK virus infection | 25.77 | 12.70 | 47 | 117578 | 7942 | 70802877 |
Pancreatitis | 25.75 | 12.70 | 40 | 117585 | 62628 | 70748191 |
Diabetes mellitus | 25.73 | 12.70 | 50 | 117575 | 71774 | 70739045 |
Metastatic neoplasm | 25.67 | 12.70 | 35 | 117590 | 4613 | 70806206 |
Pain in jaw | 25.50 | 12.70 | 20 | 117605 | 42649 | 70768170 |
Haemoptysis | 25.32 | 12.70 | 159 | 117466 | 51293 | 70759526 |
Swollen tongue | 25.30 | 12.70 | 15 | 117610 | 37031 | 70773788 |
Prostate cancer | 25.26 | 12.70 | 10 | 117615 | 31153 | 70779666 |
Aortitis | 25.25 | 12.70 | 20 | 117605 | 1391 | 70809428 |
Diaphragm muscle weakness | 25.20 | 12.70 | 10 | 117615 | 174 | 70810645 |
Device related infection | 25.15 | 12.70 | 113 | 117512 | 32072 | 70778747 |
Gout | 25.14 | 12.70 | 4 | 117621 | 23002 | 70787817 |
Prescribed underdose | 25.06 | 12.70 | 3 | 117622 | 21382 | 70789437 |
Tracheo-oesophageal fistula | 25.01 | 12.70 | 14 | 117611 | 542 | 70810277 |
Haemoglobin decreased | 24.83 | 12.70 | 478 | 117147 | 204681 | 70606138 |
Hip fracture | 24.73 | 12.70 | 8 | 117617 | 28255 | 70782564 |
Encephalopathy | 24.64 | 12.70 | 181 | 117444 | 61480 | 70749339 |
Haemophagocytic lymphohistiocytosis | 24.54 | 12.70 | 80 | 117545 | 19532 | 70791287 |
Wound evisceration | 24.53 | 12.70 | 9 | 117616 | 125 | 70810694 |
Rib fracture | 24.37 | 12.70 | 6 | 117619 | 25350 | 70785469 |
Accidental overdose | 24.29 | 12.70 | 14 | 117611 | 35107 | 70775712 |
Dysstasia | 24.12 | 12.70 | 6 | 117619 | 25173 | 70785646 |
Granulocyte-colony stimulating factor level increased | 24.09 | 12.70 | 5 | 117620 | 4 | 70810815 |
Gene mutation | 24.04 | 12.70 | 24 | 117601 | 2267 | 70808552 |
Melanosis | 24.00 | 12.70 | 7 | 117618 | 44 | 70810775 |
Rhinorrhoea | 23.95 | 12.70 | 46 | 117579 | 66325 | 70744494 |
Nightmare | 23.88 | 12.70 | 4 | 117621 | 22152 | 70788667 |
Acne | 23.85 | 12.70 | 6 | 117619 | 24983 | 70785836 |
Medulloblastoma recurrent | 23.84 | 12.70 | 9 | 117616 | 136 | 70810683 |
Sopor | 23.80 | 12.70 | 11 | 117614 | 31256 | 70779563 |
Ovarian vein thrombosis | 23.73 | 12.70 | 7 | 117618 | 46 | 70810773 |
Oesophageal squamous cell carcinoma | 23.49 | 12.70 | 13 | 117612 | 492 | 70810327 |
Liver function test abnormal | 23.29 | 12.70 | 41 | 117584 | 61105 | 70749714 |
Myeloid leukaemia | 23.18 | 12.70 | 14 | 117611 | 626 | 70810193 |
Hepatic cirrhosis | 23.11 | 12.70 | 11 | 117614 | 30720 | 70780099 |
Asthenia | 23.08 | 12.70 | 953 | 116672 | 456713 | 70354106 |
Night sweats | 23.07 | 12.70 | 23 | 117602 | 43661 | 70767158 |
Chest discomfort | 22.96 | 12.70 | 117 | 117508 | 124264 | 70686555 |
Lymphadenopathy | 22.91 | 12.70 | 149 | 117476 | 48642 | 70762177 |
Stem cell transplant | 22.90 | 12.70 | 29 | 117596 | 3556 | 70807263 |
Varicella zoster virus infection | 22.72 | 12.70 | 31 | 117594 | 4089 | 70806730 |
Nephrolithiasis | 22.68 | 12.70 | 27 | 117598 | 47296 | 70763523 |
Movement disorder | 22.64 | 12.70 | 6 | 117619 | 24123 | 70786696 |
Crying | 22.47 | 12.70 | 4 | 117621 | 21195 | 70789624 |
Retroperitoneal neoplasm metastatic | 22.42 | 12.70 | 6 | 117619 | 26 | 70810793 |
Frequent bowel movements | 22.40 | 12.70 | 4 | 117621 | 21149 | 70789670 |
Tooth disorder | 22.37 | 12.70 | 6 | 117619 | 23932 | 70786887 |
Pharyngeal inflammation | 22.34 | 12.70 | 16 | 117609 | 956 | 70809863 |
Oral candidiasis | 22.11 | 12.70 | 91 | 117534 | 24861 | 70785958 |
Fanconi syndrome acquired | 22.08 | 12.70 | 24 | 117601 | 2503 | 70808316 |
Staphylococcal infection | 22.05 | 12.70 | 158 | 117467 | 53246 | 70757573 |
Aortic embolus | 22.01 | 12.70 | 7 | 117618 | 61 | 70810758 |
Lymphangiosis carcinomatosa | 21.98 | 12.70 | 21 | 117604 | 1880 | 70808939 |
Ileus | 21.95 | 12.70 | 89 | 117536 | 24148 | 70786671 |
Dyspnoea | 21.92 | 12.70 | 1049 | 116576 | 769011 | 70041808 |
Myelitis transverse | 21.87 | 12.70 | 20 | 117605 | 1694 | 70809125 |
Retinopathy | 21.83 | 12.70 | 28 | 117597 | 3478 | 70807341 |
Medication error | 21.82 | 12.70 | 38 | 117587 | 56874 | 70753945 |
Fistula of small intestine | 21.78 | 12.70 | 14 | 117611 | 699 | 70810120 |
Angina pectoris | 21.74 | 12.70 | 29 | 117596 | 48354 | 70762465 |
Purulent pericarditis | 21.71 | 12.70 | 7 | 117618 | 64 | 70810755 |
Arteritis | 21.64 | 12.70 | 15 | 117610 | 850 | 70809969 |
Gingivitis ulcerative | 21.54 | 12.70 | 10 | 117615 | 259 | 70810560 |
Subclavian vein thrombosis | 21.54 | 12.70 | 23 | 117602 | 2351 | 70808468 |
Product quality issue | 21.40 | 12.70 | 12 | 117613 | 30549 | 70780270 |
Cystitis | 21.23 | 12.70 | 28 | 117597 | 46913 | 70763906 |
Transitional cell carcinoma recurrent | 21.22 | 12.70 | 5 | 117620 | 11 | 70810808 |
Renal tubular dysfunction | 21.19 | 12.70 | 14 | 117611 | 733 | 70810086 |
Iron deficiency anaemia | 21.15 | 12.70 | 6 | 117619 | 23066 | 70787753 |
Blood culture positive | 21.11 | 12.70 | 43 | 117582 | 7883 | 70802936 |
Viral load increased | 21.10 | 12.70 | 24 | 117601 | 2632 | 70808187 |
Abnormal behaviour | 21.08 | 12.70 | 16 | 117609 | 34693 | 70776126 |
Ischaemic stroke | 21.00 | 12.70 | 104 | 117521 | 30716 | 70780103 |
Adverse event | 20.87 | 12.70 | 31 | 117594 | 49430 | 70761389 |
Enterocolitis infectious | 20.82 | 12.70 | 24 | 117601 | 2670 | 70808149 |
Granulocyte count decreased | 20.78 | 12.70 | 18 | 117607 | 1419 | 70809400 |
Folliculitis | 20.71 | 12.70 | 24 | 117601 | 42546 | 70768273 |
Amputation stump pain | 20.67 | 12.70 | 6 | 117619 | 37 | 70810782 |
Iliac artery occlusion | 20.54 | 12.70 | 10 | 117615 | 289 | 70810530 |
Hyperlipidaemia | 20.45 | 12.70 | 7 | 117618 | 23856 | 70786963 |
Hallucination, auditory | 20.45 | 12.70 | 3 | 117622 | 18325 | 70792494 |
Ovarian cancer recurrent | 20.44 | 12.70 | 12 | 117613 | 509 | 70810310 |
Bone marrow disorder | 20.44 | 12.70 | 25 | 117600 | 2960 | 70807859 |
Bradycardia | 20.39 | 12.70 | 122 | 117503 | 124493 | 70686326 |
Mood swings | 20.39 | 12.70 | 3 | 117622 | 18283 | 70792536 |
Renal tubular injury | 20.39 | 12.70 | 17 | 117608 | 1272 | 70809547 |
Hypercalcaemia of malignancy | 20.35 | 12.70 | 11 | 117614 | 397 | 70810422 |
Gastrointestinal necrosis | 20.30 | 12.70 | 33 | 117592 | 5085 | 70805734 |
Muscle spasticity | 20.26 | 12.70 | 4 | 117621 | 19685 | 70791134 |
Subcutaneous emphysema | 20.24 | 12.70 | 19 | 117606 | 1663 | 70809156 |
Conductive deafness | 20.24 | 12.70 | 7 | 117618 | 81 | 70810738 |
Transplant rejection | 20.22 | 12.70 | 3 | 117622 | 18168 | 70792651 |
Colitis ulcerative | 20.15 | 12.70 | 16 | 117609 | 33907 | 70776912 |
Immune-mediated hepatic disorder | 20.13 | 12.70 | 15 | 117610 | 953 | 70809866 |
Acute promyelocytic leukaemia | 20.09 | 12.70 | 18 | 117607 | 1484 | 70809335 |
Azoospermia | 20.07 | 12.70 | 8 | 117617 | 141 | 70810678 |
Metastases to pleura | 20.06 | 12.70 | 17 | 117608 | 1301 | 70809518 |
Non-small cell lung cancer metastatic | 20.04 | 12.70 | 15 | 117610 | 959 | 70809860 |
Metastases to abdominal cavity | 20.02 | 12.70 | 12 | 117613 | 529 | 70810290 |
Jaw operation | 20.02 | 12.70 | 14 | 117611 | 805 | 70810014 |
Chromaturia | 20.00 | 12.70 | 7 | 117618 | 23521 | 70787298 |
Apparent mineralocorticoid excess | 19.89 | 12.70 | 6 | 117619 | 43 | 70810776 |
Uterine atrophy | 19.87 | 12.70 | 5 | 117620 | 16 | 70810803 |
Amnesia | 19.84 | 12.70 | 35 | 117590 | 52120 | 70758699 |
Immune-mediated dermatitis | 19.83 | 12.70 | 10 | 117615 | 312 | 70810507 |
Hypersomnia | 19.79 | 12.70 | 5 | 117620 | 20759 | 70790060 |
Extrapyramidal disorder | 19.77 | 12.70 | 5 | 117620 | 20745 | 70790074 |
Pneumonia | 19.76 | 12.70 | 1192 | 116433 | 595040 | 70215779 |
Osteomyelitis | 19.70 | 12.70 | 13 | 117612 | 30305 | 70780514 |
Pharyngeal stenosis | 19.64 | 12.70 | 5 | 117620 | 17 | 70810802 |
Multiple organ dysfunction syndrome | 19.53 | 12.70 | 270 | 117355 | 108245 | 70702574 |
Abdominal pain upper | 19.50 | 12.70 | 216 | 117409 | 193386 | 70617433 |
Hyperammonaemic encephalopathy | 19.49 | 12.70 | 30 | 117595 | 4413 | 70806406 |
Liver abscess | 19.42 | 12.70 | 34 | 117591 | 5565 | 70805254 |
Oroticaciduria | 19.38 | 12.70 | 4 | 117621 | 3 | 70810816 |
Surgery | 19.30 | 12.70 | 13 | 117612 | 29976 | 70780843 |
Thymoma malignant | 19.21 | 12.70 | 5 | 117620 | 19 | 70810800 |
Transient ischaemic attack | 19.19 | 12.70 | 29 | 117596 | 45915 | 70764904 |
Staphylococcus test positive | 19.17 | 12.70 | 35 | 117590 | 5919 | 70804900 |
Alveolar soft part sarcoma | 19.16 | 12.70 | 7 | 117618 | 96 | 70810723 |
Carotid artery dissection | 19.10 | 12.70 | 10 | 117615 | 338 | 70810481 |
Anti-Muellerian hormone level decreased | 19.10 | 12.70 | 7 | 117618 | 97 | 70810722 |
Dropped head syndrome | 19.05 | 12.70 | 9 | 117616 | 243 | 70810576 |
Retinal ischaemia | 19.01 | 12.70 | 13 | 117612 | 721 | 70810098 |
Heart rate irregular | 19.00 | 12.70 | 13 | 117612 | 29730 | 70781089 |
Chemotherapeutic drug level increased | 18.97 | 12.70 | 10 | 117615 | 343 | 70810476 |
Chemotherapy | 18.96 | 12.70 | 18 | 117607 | 1598 | 70809221 |
Mucosal toxicity | 18.95 | 12.70 | 12 | 117613 | 584 | 70810235 |
Hypovolaemia | 18.91 | 12.70 | 64 | 117561 | 15929 | 70794890 |
Lung abscess | 18.90 | 12.70 | 27 | 117598 | 3717 | 70807102 |
Oesophageal squamous cell carcinoma metastatic | 18.85 | 12.70 | 4 | 117621 | 4 | 70810815 |
Trigeminal nerve paresis | 18.85 | 12.70 | 4 | 117621 | 4 | 70810815 |
Maternal death affecting foetus | 18.85 | 12.70 | 4 | 117621 | 4 | 70810815 |
Bone sarcoma | 18.84 | 12.70 | 7 | 117618 | 101 | 70810718 |
Sinus polyp | 18.81 | 12.70 | 11 | 117614 | 463 | 70810356 |
Thrombocytopenia neonatal | 18.81 | 12.70 | 5 | 117620 | 21 | 70810798 |
Cervix carcinoma recurrent | 18.81 | 12.70 | 5 | 117620 | 21 | 70810798 |
Ureteric dilatation | 18.69 | 12.70 | 8 | 117617 | 170 | 70810649 |
Haemoperitoneum | 18.58 | 12.70 | 28 | 117597 | 4043 | 70806776 |
Mental disorder | 18.50 | 12.70 | 12 | 117613 | 28228 | 70782591 |
Axillary vein thrombosis | 18.48 | 12.70 | 12 | 117613 | 610 | 70810209 |
Clostridium colitis | 18.40 | 12.70 | 22 | 117603 | 2544 | 70808275 |
Metastases to retroperitoneum | 18.30 | 12.70 | 10 | 117615 | 369 | 70810450 |
Dystonia | 18.30 | 12.70 | 5 | 117620 | 19701 | 70791118 |
Testicular cancer metastatic | 18.22 | 12.70 | 6 | 117619 | 59 | 70810760 |
Vertigo | 18.08 | 12.70 | 49 | 117576 | 62594 | 70748225 |
Glaucoma | 17.95 | 12.70 | 4 | 117621 | 18088 | 70792731 |
Embolism arterial | 17.92 | 12.70 | 16 | 117609 | 1313 | 70809506 |
Sweat gland tumour | 17.91 | 12.70 | 11 | 117614 | 507 | 70810312 |
Malignant pleural effusion | 17.89 | 12.70 | 24 | 117601 | 3115 | 70807704 |
Gastrointestinal ischaemia | 17.68 | 12.70 | 10 | 117615 | 395 | 70810424 |
Granulocytopenia | 17.67 | 12.70 | 48 | 117577 | 10599 | 70800220 |
Liver function test increased | 17.67 | 12.70 | 18 | 117607 | 33829 | 70776990 |
Rash pruritic | 17.64 | 12.70 | 50 | 117575 | 62941 | 70747878 |
Recurrent cancer | 17.62 | 12.70 | 21 | 117604 | 2420 | 70808399 |
Squamous cell carcinoma of head and neck | 17.61 | 12.70 | 9 | 117616 | 289 | 70810530 |
Laryngeal pain | 17.60 | 12.70 | 33 | 117592 | 5695 | 70805124 |
Eczema | 17.59 | 12.70 | 18 | 117607 | 33763 | 70777056 |
Campylobacter test positive | 17.54 | 12.70 | 6 | 117619 | 67 | 70810752 |
Delusion | 17.54 | 12.70 | 5 | 117620 | 19160 | 70791659 |
Eye irritation | 17.51 | 12.70 | 4 | 117621 | 17784 | 70793035 |
Pericardial effusion | 17.48 | 12.70 | 124 | 117501 | 41652 | 70769167 |
Procedural vomiting | 17.39 | 12.70 | 12 | 117613 | 675 | 70810144 |
Adenoviral hepatitis | 17.36 | 12.70 | 13 | 117612 | 832 | 70809987 |
Hot flush | 17.34 | 12.70 | 35 | 117590 | 49549 | 70761270 |
Clostridium bacteraemia | 17.31 | 12.70 | 9 | 117616 | 300 | 70810519 |
Synovial sarcoma | 17.30 | 12.70 | 6 | 117619 | 70 | 70810749 |
Acute myelomonocytic leukaemia | 17.28 | 12.70 | 9 | 117616 | 301 | 70810518 |
Sinus disorder | 17.25 | 12.70 | 5 | 117620 | 18954 | 70791865 |
Extragonadal primary germ cell tumour mixed | 17.23 | 12.70 | 4 | 117621 | 8 | 70810811 |
Cardiac pseudoaneurysm | 17.23 | 12.70 | 6 | 117619 | 71 | 70810748 |
Morphoea | 17.21 | 12.70 | 10 | 117615 | 416 | 70810403 |
Median nerve injury | 17.20 | 12.70 | 5 | 117620 | 31 | 70810788 |
Neck pain | 17.16 | 12.70 | 55 | 117570 | 66602 | 70744217 |
Small intestinal perforation | 17.14 | 12.70 | 23 | 117602 | 2986 | 70807833 |
Joint range of motion decreased | 17.13 | 12.70 | 11 | 117614 | 26015 | 70784804 |
Embryonal rhabdomyosarcoma | 17.08 | 12.70 | 6 | 117619 | 73 | 70810746 |
Depressed mood | 17.04 | 12.70 | 29 | 117596 | 43791 | 70767028 |
Embolism venous | 16.92 | 12.70 | 26 | 117599 | 3819 | 70807000 |
Sinus congestion | 16.92 | 12.70 | 4 | 117621 | 17369 | 70793450 |
Jugular vein occlusion | 16.92 | 12.70 | 4 | 117621 | 9 | 70810810 |
Carotid artery thrombosis | 16.91 | 12.70 | 21 | 117604 | 2525 | 70808294 |
Sarcomatoid carcinoma | 16.80 | 12.70 | 5 | 117620 | 34 | 70810785 |
Neoplasm malignant | 16.79 | 12.70 | 93 | 117532 | 28681 | 70782138 |
Metastases to abdominal wall | 16.70 | 12.70 | 7 | 117618 | 141 | 70810678 |
Clonal haematopoiesis | 16.68 | 12.70 | 5 | 117620 | 35 | 70810784 |
Portal vein thrombosis | 16.61 | 12.70 | 31 | 117594 | 5331 | 70805488 |
Ganglioneuroma | 16.56 | 12.70 | 7 | 117618 | 144 | 70810675 |
Restless legs syndrome | 16.51 | 12.70 | 5 | 117620 | 18423 | 70792396 |
Vascular injury | 16.48 | 12.70 | 14 | 117611 | 1075 | 70809744 |
Staphylococcal bacteraemia | 16.46 | 12.70 | 48 | 117577 | 11034 | 70799785 |
Intentional product use issue | 16.46 | 12.70 | 124 | 117501 | 120018 | 70690801 |
Venous thrombosis | 16.46 | 12.70 | 35 | 117590 | 6614 | 70804205 |
Herpes zoster | 16.41 | 12.70 | 79 | 117546 | 85156 | 70725663 |
Lung cancer metastatic | 16.38 | 12.70 | 24 | 117601 | 3381 | 70807438 |
Organising pneumonia | 16.37 | 12.70 | 45 | 117580 | 10005 | 70800814 |
Thrombophlebitis migrans | 16.35 | 12.70 | 9 | 117616 | 337 | 70810482 |
Pneumonia adenoviral | 16.26 | 12.70 | 10 | 117615 | 462 | 70810357 |
Sepsis pasteurella | 16.21 | 12.70 | 3 | 117622 | 0 | 70810819 |
Emphysematous cholecystitis | 16.21 | 12.70 | 3 | 117622 | 0 | 70810819 |
Oesophageal squamous cell carcinoma recurrent | 16.21 | 12.70 | 3 | 117622 | 0 | 70810819 |
Kidney infection | 16.17 | 12.70 | 6 | 117619 | 19449 | 70791370 |
Dysphonia | 16.16 | 12.70 | 37 | 117588 | 50063 | 70760756 |
Disturbance in attention | 16.12 | 12.70 | 29 | 117596 | 42865 | 70767954 |
Metapneumovirus bronchiolitis | 16.09 | 12.70 | 4 | 117621 | 12 | 70810807 |
Paraneoplastic syndrome | 16.07 | 12.70 | 13 | 117612 | 932 | 70809887 |
Leukaemic lymphoma | 16.06 | 12.70 | 6 | 117619 | 88 | 70810731 |
Alopecia | 16.05 | 12.70 | 232 | 117393 | 198258 | 70612561 |
Cannabinoid hyperemesis syndrome | 15.99 | 12.70 | 5 | 117620 | 41 | 70810778 |
Non-small cell lung cancer stage IIIB | 15.88 | 12.70 | 5 | 117620 | 42 | 70810777 |
Marchiafava-Bignami disease | 15.85 | 12.70 | 4 | 117621 | 13 | 70810806 |
Bone erosion | 15.78 | 12.70 | 3 | 117622 | 15170 | 70795649 |
Retinal toxicity | 15.72 | 12.70 | 15 | 117610 | 1341 | 70809478 |
Depressed level of consciousness | 15.71 | 12.70 | 83 | 117542 | 87348 | 70723471 |
Respiratory arrest | 15.70 | 12.70 | 42 | 117583 | 53891 | 70756928 |
Skin toxicity | 15.68 | 12.70 | 36 | 117589 | 7162 | 70803657 |
Device malfunction | 15.67 | 12.70 | 6 | 117619 | 19078 | 70791741 |
Myositis | 15.66 | 12.70 | 64 | 117561 | 17425 | 70793394 |
Gastroenteritis viral | 15.65 | 12.70 | 8 | 117617 | 21447 | 70789372 |
Thrombophlebitis | 15.65 | 12.70 | 32 | 117593 | 5884 | 70804935 |
Therapy interrupted | 15.63 | 12.70 | 11 | 117614 | 24791 | 70786028 |
Skin exfoliation | 15.62 | 12.70 | 36 | 117589 | 48590 | 70762229 |
Proctitis | 15.57 | 12.70 | 24 | 117601 | 3534 | 70807285 |
Toxic leukoencephalopathy | 15.43 | 12.70 | 13 | 117612 | 987 | 70809832 |
Eosinophilia | 15.39 | 12.70 | 27 | 117598 | 40292 | 70770527 |
Necrosis ischaemic | 15.38 | 12.70 | 13 | 117612 | 991 | 70809828 |
Cell-mediated immune deficiency | 15.36 | 12.70 | 6 | 117619 | 100 | 70810719 |
Dementia | 15.35 | 12.70 | 9 | 117616 | 22356 | 70788463 |
Metastases to thorax | 15.35 | 12.70 | 7 | 117618 | 174 | 70810645 |
Meningitis tuberculous | 15.33 | 12.70 | 14 | 117611 | 1183 | 70809636 |
Hernia | 15.33 | 12.70 | 3 | 117622 | 14857 | 70795962 |
Body temperature decreased | 15.25 | 12.70 | 15 | 117610 | 28657 | 70782162 |
Hypertension | 15.24 | 12.70 | 374 | 117251 | 295659 | 70515160 |
Noctiphobia | 15.20 | 12.70 | 4 | 117621 | 16 | 70810803 |
Gastrointestinal haemorrhage | 15.18 | 12.70 | 150 | 117475 | 137258 | 70673561 |
Upper limb fracture | 15.14 | 12.70 | 4 | 117621 | 16115 | 70794704 |
Hepatoblastoma | 15.11 | 12.70 | 5 | 117620 | 50 | 70810769 |
Hypoxia | 15.11 | 12.70 | 228 | 117397 | 93116 | 70717703 |
Fistula | 15.09 | 12.70 | 46 | 117579 | 10835 | 70799984 |
Cellulitis | 15.07 | 12.70 | 99 | 117526 | 98829 | 70711990 |
Muscle twitching | 15.05 | 12.70 | 7 | 117618 | 19820 | 70790999 |
Death | 15.03 | 12.70 | 692 | 116933 | 509369 | 70301450 |
Spinal stenosis | 15.03 | 12.70 | 3 | 117622 | 14650 | 70796169 |
Metastases to the mediastinum | 14.96 | 12.70 | 10 | 117615 | 534 | 70810285 |
Platelet transfusion | 14.93 | 12.70 | 18 | 117607 | 2100 | 70808719 |
Immune-mediated myocarditis | 14.79 | 12.70 | 11 | 117614 | 697 | 70810122 |
Neoplasm | 14.75 | 12.70 | 37 | 117588 | 7787 | 70803032 |
Cerebral salt-wasting syndrome | 14.73 | 12.70 | 6 | 117619 | 112 | 70810707 |
Blood loss anaemia | 14.72 | 12.70 | 3 | 117622 | 14438 | 70796381 |
Pulmonary artery thrombosis | 14.69 | 12.70 | 14 | 117611 | 1249 | 70809570 |
Paraneoplastic dermatomyositis | 14.69 | 12.70 | 5 | 117620 | 55 | 70810764 |
Cervix cancer metastatic | 14.65 | 12.70 | 4 | 117621 | 19 | 70810800 |
Myasthenic syndrome | 14.65 | 12.70 | 11 | 117614 | 707 | 70810112 |
Nasopharyngeal cancer | 14.61 | 12.70 | 7 | 117618 | 195 | 70810624 |
Enterobacter infection | 14.53 | 12.70 | 25 | 117600 | 4035 | 70806784 |
Haematochezia | 14.50 | 12.70 | 67 | 117558 | 73014 | 70737805 |
Oral fungal infection | 14.46 | 12.70 | 22 | 117603 | 3204 | 70807615 |
Evans syndrome | 14.46 | 12.70 | 9 | 117616 | 425 | 70810394 |
Metastases to pelvis | 14.44 | 12.70 | 10 | 117615 | 566 | 70810253 |
Cytokine release syndrome | 14.42 | 12.70 | 84 | 117541 | 26383 | 70784436 |
Adrenal insufficiency | 14.41 | 12.70 | 81 | 117544 | 25114 | 70785705 |
Ovarian failure | 14.41 | 12.70 | 10 | 117615 | 568 | 70810251 |
Pelvic fluid collection | 14.41 | 12.70 | 11 | 117614 | 725 | 70810094 |
Hypoglossal nerve paresis | 14.40 | 12.70 | 6 | 117619 | 119 | 70810700 |
Procedural nausea | 14.34 | 12.70 | 11 | 117614 | 730 | 70810089 |
Intestinal infarction | 14.33 | 12.70 | 14 | 117611 | 1288 | 70809531 |
Diabetes mellitus inadequate control | 14.33 | 12.70 | 10 | 117615 | 22635 | 70788184 |
Conjunctivitis | 14.31 | 12.70 | 10 | 117615 | 22626 | 70788193 |
Pneumonia salmonella | 14.29 | 12.70 | 5 | 117620 | 60 | 70810759 |
Enterococcal bacteraemia | 14.26 | 12.70 | 20 | 117605 | 2706 | 70808113 |
Anaplastic lymphoma kinase gene mutation | 14.26 | 12.70 | 6 | 117619 | 122 | 70810697 |
Procedural pain | 14.24 | 12.70 | 6 | 117619 | 18003 | 70792816 |
Poor quality sleep | 14.23 | 12.70 | 8 | 117617 | 20341 | 70790478 |
Renal-limited thrombotic microangiopathy | 14.16 | 12.70 | 4 | 117621 | 22 | 70810797 |
Carotid artery perforation | 14.14 | 12.70 | 3 | 117622 | 3 | 70810816 |
Epithelioid mesothelioma | 14.14 | 12.70 | 3 | 117622 | 3 | 70810816 |
Non-renal cell carcinoma of kidney | 14.14 | 12.70 | 3 | 117622 | 3 | 70810816 |
Endothelial dysfunction | 14.11 | 12.70 | 7 | 117618 | 211 | 70810608 |
Vascular pseudoaneurysm | 14.08 | 12.70 | 22 | 117603 | 3279 | 70807540 |
BRAF gene mutation | 14.07 | 12.70 | 5 | 117620 | 63 | 70810756 |
Thymus enlargement | 14.04 | 12.70 | 6 | 117619 | 127 | 70810692 |
Laryngeal cancer stage IV | 14.01 | 12.70 | 4 | 117621 | 23 | 70810796 |
B-cell lymphoma refractory | 14.00 | 12.70 | 6 | 117619 | 128 | 70810691 |
Unresponsive to stimuli | 13.97 | 12.70 | 42 | 117583 | 51889 | 70758930 |
Stent malfunction | 13.93 | 12.70 | 5 | 117620 | 65 | 70810754 |
Vaginitis gardnerella | 13.87 | 12.70 | 4 | 117621 | 24 | 70810795 |
Nephropathy | 13.86 | 12.70 | 39 | 117586 | 8786 | 70802033 |
Thrombocytosis | 13.83 | 12.70 | 36 | 117589 | 7748 | 70803071 |
Mood altered | 13.83 | 12.70 | 5 | 117620 | 16470 | 70794349 |
Dyspnoea exertional | 13.79 | 12.70 | 75 | 117550 | 78355 | 70732464 |
Culture urine positive | 13.76 | 12.70 | 25 | 117600 | 4212 | 70806607 |
Adenocarcinoma | 13.74 | 12.70 | 23 | 117602 | 3630 | 70807189 |
Enterococcal sepsis | 13.74 | 12.70 | 19 | 117606 | 2538 | 70808281 |
Fracture | 13.72 | 12.70 | 8 | 117617 | 19936 | 70790883 |
Oesophageal prosthesis insertion | 13.68 | 12.70 | 3 | 117622 | 4 | 70810815 |
Abdominal pain | 13.66 | 12.70 | 696 | 116929 | 341431 | 70469388 |
Skin ulcer | 13.64 | 12.70 | 38 | 117587 | 48107 | 70762712 |
Neuroblastoma | 13.61 | 12.70 | 8 | 117617 | 340 | 70810479 |
Rhabdoid tumour | 13.60 | 12.70 | 4 | 117621 | 26 | 70810793 |
VIth nerve paresis | 13.58 | 12.70 | 6 | 117619 | 138 | 70810681 |
Thrombotic thrombocytopenic purpura | 13.57 | 12.70 | 31 | 117594 | 6146 | 70804673 |
Retroperitoneal neoplasm | 13.47 | 12.70 | 4 | 117621 | 27 | 70810792 |
Glycosylated haemoglobin increased | 13.42 | 12.70 | 6 | 117619 | 17385 | 70793434 |
Fear | 13.42 | 12.70 | 9 | 117616 | 20802 | 70790017 |
Mydriasis | 13.40 | 12.70 | 5 | 117620 | 16148 | 70794671 |
Tachycardia | 13.37 | 12.70 | 351 | 117274 | 158195 | 70652624 |
Streptococcus test positive | 13.37 | 12.70 | 17 | 117608 | 2094 | 70808725 |
Adenocarcinoma of appendix | 13.34 | 12.70 | 5 | 117620 | 74 | 70810745 |
Head and neck cancer | 13.33 | 12.70 | 7 | 117618 | 238 | 70810581 |
Oxygen saturation decreased | 13.32 | 12.70 | 126 | 117499 | 116303 | 70694516 |
Capillary leak syndrome | 13.30 | 12.70 | 22 | 117603 | 3440 | 70807379 |
Paranoia | 13.29 | 12.70 | 6 | 117619 | 17282 | 70793537 |
Epiphyses premature fusion | 13.28 | 12.70 | 5 | 117620 | 75 | 70810744 |
Hyperglycaemic hyperosmolar nonketotic syndrome | 13.25 | 12.70 | 16 | 117609 | 1870 | 70808949 |
Gastroenteritis sapovirus | 13.23 | 12.70 | 6 | 117619 | 147 | 70810672 |
Immune-mediated lung disease | 13.21 | 12.70 | 15 | 117610 | 1642 | 70809177 |
Metastases to bladder | 13.17 | 12.70 | 7 | 117618 | 244 | 70810575 |
Hypothermia | 13.15 | 12.70 | 9 | 117616 | 20585 | 70790234 |
Hemianopia | 13.15 | 12.70 | 15 | 117610 | 1650 | 70809169 |
Mania | 13.14 | 12.70 | 6 | 117619 | 17168 | 70793651 |
Retroperitoneal lymphadenopathy | 13.10 | 12.70 | 12 | 117613 | 1018 | 70809801 |
Systemic infection | 13.10 | 12.70 | 32 | 117593 | 6625 | 70804194 |
Eye pruritus | 13.08 | 12.70 | 4 | 117621 | 14643 | 70796176 |
White blood cell disorder | 13.07 | 12.70 | 20 | 117605 | 2928 | 70807891 |
Diabetic ketoacidosis | 13.05 | 12.70 | 20 | 117605 | 31492 | 70779327 |
Blood iron decreased | 13.02 | 12.70 | 3 | 117622 | 13258 | 70797561 |
Carpal tunnel syndrome | 12.99 | 12.70 | 6 | 117619 | 17051 | 70793768 |
Hepatic function abnormal | 12.98 | 12.70 | 171 | 117454 | 67825 | 70742994 |
Coma | 12.96 | 12.70 | 94 | 117531 | 91750 | 70719069 |
Peritoneal sarcoma | 12.93 | 12.70 | 3 | 117622 | 6 | 70810813 |
Stoma site dermatitis | 12.93 | 12.70 | 3 | 117622 | 6 | 70810813 |
Visual impairment | 12.90 | 12.70 | 79 | 117546 | 80171 | 70730648 |
Feeling cold | 12.89 | 12.70 | 14 | 117611 | 25556 | 70785263 |
Metastatic squamous cell carcinoma | 12.88 | 12.70 | 9 | 117616 | 517 | 70810302 |
Germ cell cancer | 12.84 | 12.70 | 6 | 117619 | 158 | 70810661 |
Blood phosphorus decreased | 12.83 | 12.70 | 30 | 117595 | 6039 | 70804780 |
Delirium | 12.76 | 12.70 | 72 | 117553 | 74542 | 70736277 |
Cough | 12.72 | 12.70 | 427 | 117198 | 324950 | 70485869 |
None
Source | Code | Description |
---|---|---|
ATC | L01XA01 | ANTINEOPLASTIC AND IMMUNOMODULATING AGENTS ANTINEOPLASTIC AGENTS OTHER ANTINEOPLASTIC AGENTS Platinum compounds |
FDA EXT | N0000175073 | Platinum-containing Compounds |
FDA EPC | N0000175413 | Platinum-based Drug |
MeSH PA | D000970 | Antineoplastic Agents |
MeSH PA | D003432 | Cross-Linking Reagents |
MeSH PA | D007202 | Indicators and Reagents |
MeSH PA | D011838 | Radiation-Sensitizing Agents |
CHEBI has role | CHEBI:25435 | mutagens |
CHEBI has role | CHEBI:35610 | antineoplastic agents |
CHEBI has role | CHEBI:47868 | photosensitising agent |
CHEBI has role | CHEBI:50684 | cross-linking reagents |
CHEBI has role | CHEBI:50902 | genotoxic agent |
CHEBI has role | CHEBI:61015 | nephrotoxins |
CHEBI has role | CHEBI:68495 | Type I cell-death inducers |
CHEBI has role | CHEBI:173085 | ferroptosis inducers |
Disease | Relation | SNOMED_ID | DOID |
---|---|---|---|
Malignant tumor of ovary | indication | 363443007 | DOID:2394 |
Ovarian Germ Cell Tumor Carcinoma | indication | ||
Testicular Germ Cell Tumor | indication | ||
Invasive Bladder Malignancy | indication |
None
None
None
None
None
Target | Class | Pharos | UniProt | Action | Type | Activity value (-log[M]) | Mechanism action | Bioact source | MoA source |
---|---|---|---|---|---|---|---|---|---|
D(3) dopamine receptor | GPCR | Ki | 5.95 | CHEMBL | |||||
Muscarinic acetylcholine receptor M5 | GPCR | Ki | 5.37 | CHEMBL | |||||
Canalicular multispecific organic anion transporter 1 | Transporter | WOMBAT-PK | |||||||
Adenosine receptor A3 | GPCR | Ki | 5.62 | DRUG MATRIX | |||||
Multidrug resistance-associated protein 6 | Transporter | WOMBAT-PK | |||||||
Multidrug resistance-associated protein 5 | Transporter | WOMBAT-PK | |||||||
Epidermal growth factor receptor | Kinase | IC50 | 5.58 | DRUG MATRIX | |||||
Tyrosine-protein kinase Lck | Kinase | IC50 | 4.64 | DRUG MATRIX | |||||
Tyrosine-protein kinase Fyn | Kinase | IC50 | 5.32 | DRUG MATRIX | |||||
C-X-C chemokine receptor type 2 | GPCR | Ki | 5.02 | DRUG MATRIX | |||||
Thromboxane-A synthase | Enzyme | IC50 | 5.03 | DRUG MATRIX | |||||
C-C chemokine receptor type 2 | GPCR | Ki | 5.15 | DRUG MATRIX | |||||
Mitogen-activated protein kinase 3 | Kinase | IC50 | 5.34 | DRUG MATRIX | |||||
Melanocortin receptor 5 | GPCR | Ki | 5.22 | DRUG MATRIX | |||||
Sodium/potassium-transporting ATPase subunit alpha-2 | Ion channel | IC50 | 5.03 | DRUG MATRIX |
ID | Source |
---|---|
D00275 | KEGG_DRUG |
4018139 | VUID |
N0000146476 | NUI |
4018139 | VANDF |
C0008838 | UMLSCUI |
CHEBI:27899 | CHEBI |
CPT | PDB_CHEM_ID |
CHEMBL1386 | ChEMBL_ID |
CHEMBL11359 | ChEMBL_ID |
CHEMBL2068237 | ChEMBL_ID |
DB00515 | DRUGBANK_ID |
5343 | IUPHAR_LIGAND_ID |
4426 | INN_ID |
Q20Q21Q62J | UNII |
5702198 | PUBCHEM_CID |
2555 | RXNORM |
31747 | MMSL |
4456 | MMSL |
d00195 | MMSL |
002641 | NDDF |
387318005 | SNOMEDCT_US |
57066004 | SNOMEDCT_US |
D002945 | MESH_DESCRIPTOR_UI |
Product | Category | Ingredients | NDC | Form | Quantity | Route | Marketing | Label |
---|---|---|---|---|---|---|---|---|
CISplatin | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0143-9504 | INJECTION | 1 mg | INTRAVENOUS | ANDA | 19 sections |
CISplatin | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0143-9505 | INJECTION | 1 mg | INTRAVENOUS | ANDA | 19 sections |
Cisplatin | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0703-5747 | INJECTION, SOLUTION | 50 mg | INTRAVENOUS | ANDA | 29 sections |
Cisplatin | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0703-5747 | INJECTION, SOLUTION | 50 mg | INTRAVENOUS | ANDA | 29 sections |
Cisplatin | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0703-5748 | INJECTION, SOLUTION | 100 mg | INTRAVENOUS | ANDA | 29 sections |
Cisplatin | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0703-5748 | INJECTION, SOLUTION | 100 mg | INTRAVENOUS | ANDA | 29 sections |
Cisplatin | HUMAN PRESCRIPTION DRUG LABEL | 1 | 16729-288 | INJECTION | 1 mg | INTRAVENOUS | ANDA | 26 sections |
CISplatin | HUMAN PRESCRIPTION DRUG LABEL | 1 | 44567-509 | INJECTION, SOLUTION | 1 mg | INTRAVENOUS | NDA | 19 sections |
CISplatin | HUMAN PRESCRIPTION DRUG LABEL | 1 | 44567-510 | INJECTION, SOLUTION | 1 mg | INTRAVENOUS | NDA | 19 sections |
CISplatin | HUMAN PRESCRIPTION DRUG LABEL | 1 | 44567-511 | INJECTION, SOLUTION | 1 mg | INTRAVENOUS | NDA | 19 sections |
Cisplatin | HUMAN PRESCRIPTION DRUG LABEL | 1 | 44567-530 | INJECTION, POWDER, LYOPHILIZED, FOR SOLUTION | 1 mg | INTRAVENOUS | NDA | 26 sections |
Cisplatin | HUMAN PRESCRIPTION DRUG LABEL | 1 | 63323-103 | INJECTION, SOLUTION | 1 mg | INTRAVENOUS | ANDA | 13 sections |
Cisplatin | HUMAN PRESCRIPTION DRUG LABEL | 1 | 68001-283 | INJECTION | 1 mg | INTRAVENOUS | ANDA | 26 sections |
CISPLATIN | Human Prescription Drug Label | 1 | 68083-162 | INJECTION, SOLUTION | 1 mg | INTRAVENOUS | ANDA | 13 sections |
CISPLATIN | Human Prescription Drug Label | 1 | 68083-163 | INJECTION, SOLUTION | 1 mg | INTRAVENOUS | ANDA | 13 sections |
Cisplatin | HUMAN PRESCRIPTION DRUG LABEL | 1 | 70860-206 | INJECTION, SOLUTION | 1 mg | INTRAVENOUS | ANDA | 21 sections |