cisplatin Indications/Contra | FAERs-F | FAERs-M | Orange Bk | BioActivity |

Stem definitionDrug idCAS RN
antineoplastic agents, platinum derivatives 4392 15663-27-1

Description:

MoleculeDescription

Synonyms:

  • cisplatin
  • platinum diamminodichloride
  • cis-Platinum
An inorganic and water-soluble platinum complex. After undergoing hydrolysis, it reacts with DNA to produce both intra and interstrand crosslinks. These crosslinks appear to impair replication and transcription of DNA. The cytotoxicity of cisplatin correlates with cellular arrest in the G2 phase of the cell cycle.
  • Molecular weight: 300.05
  • Formula: Cl2H6N2Pt
  • CLOGP:
  • LIPINSKI: None
  • HAC: None
  • HDO: None
  • TPSA:
  • ALOGS:
  • ROTB: None

Drug dosage:

None

ADMET properties:

PropertyValueReference
BDDCS (Biopharmaceutical Drug Disposition Classification System) 1 Benet LZ, Broccatelli F, Oprea TI
S (Water solubility) 2.53 mg/mL Benet LZ, Broccatelli F, Oprea TI
EoM (Fraction excreted unchanged in urine) 2.30 % Benet LZ, Broccatelli F, Oprea TI
MRTD (Maximum Recommended Therapeutic Daily Dose) 4.75 ┬ÁM/kg/day Contrera JF, Matthews EJ, Kruhlak NL, Benz RD

Approvals:

DateAgencyCompanyOrphan
Dec. 19, 1978 FDA HQ SPCLT PHARMA

FDA Adverse Event Reporting System (Female)

MedDRA adverse event termLikelihood ratioLikelihood ratio thresholdPatients taking drug having adverse eventPatients taking drug not having adverse eventPatients not taking drug having adverse eventPatients not taking drug not having adverse event
Febrile neutropenia 923.86 15.53 770 47306 93857 46544129
Neutropenia 832.47 15.53 873 47203 142331 46495655
Thrombocytopenia 508.27 15.53 638 47438 125943 46512043
Malignant neoplasm progression 438.55 15.53 430 47646 64496 46573490
Bone marrow failure 435.04 15.53 308 47768 29361 46608625
Haematotoxicity 418.09 15.53 183 47893 6750 46631236
Mucosal inflammation 397.83 15.53 326 47750 38650 46599336
Vomiting 350.23 15.53 1140 46936 451654 46186332
Disease progression 329.67 15.53 437 47639 90863 46547123
Ototoxicity 311.93 15.53 91 47985 978 46637008
Pancytopenia 272.05 15.53 384 47692 84674 46553312
Anaemia 257.53 15.53 708 47368 255071 46382915
Dehydration 237.83 15.53 514 47562 159026 46478960
Acute myeloid leukaemia 236.27 15.53 166 47910 15612 46622374
Posterior reversible encephalopathy syndrome 235.38 15.53 163 47913 14978 46623008
Second primary malignancy 223.15 15.53 117 47959 6467 46631519
Nausea 217.52 15.53 1325 46751 686129 45951857
Leukopenia 211.75 15.53 304 47772 68039 46569947
Hypomagnesaemia 202.19 15.53 174 47902 22036 46615950
Renal salt-wasting syndrome 185.22 15.53 43 48033 165 46637821
Arthralgia 183.86 15.53 73 48003 364530 46273456
Off label use 183.82 15.53 825 47251 379016 46258970
Ovarian germ cell teratoma 164.85 15.53 35 48041 78 46637908
Diffuse large B-cell lymphoma recurrent 161.47 15.53 60 48016 1432 46636554
Teratoma 160.20 15.53 37 48039 138 46637848
Deafness 158.80 15.53 132 47944 15936 46622050
Hypokalaemia 157.42 15.53 306 47770 87718 46550268
Fall 154.56 15.53 73 48003 329024 46308962
Myelosuppression 153.88 15.53 97 47979 7606 46630380
Neutrophil count decreased 144.55 15.53 200 47876 43226 46594760
Myelodysplastic syndrome 138.76 15.53 121 47955 15590 46622396
Neutropenic sepsis 136.04 15.53 108 47968 12216 46625770
Aortic thrombosis 133.86 15.53 47 48029 948 46637038
Metastases to central nervous system 127.44 15.53 100 47976 11121 46626865
Joint swelling 127.40 15.53 12 48064 166061 46471925
Gastrointestinal toxicity 127.24 15.53 70 48006 4261 46633725
Product dose omission issue 122.07 15.53 15 48061 168505 46469481
Drug ineffective 116.27 15.53 338 47738 677500 45960486
Nephropathy toxic 112.91 15.53 79 47997 7375 46630611
Diffuse large B-cell lymphoma refractory 112.57 15.53 41 48035 923 46637063
Drug hypersensitivity 111.46 15.53 56 48020 243769 46394217
Urogenital fistula 111.33 15.53 26 48050 103 46637883
Pyrexia 105.40 15.53 666 47410 348136 46289850
Neoplasm progression 104.33 15.53 133 47943 26550 46611436
Metastases to lung 103.88 15.53 87 47989 10609 46627377
Product use in unapproved indication 103.78 15.53 263 47813 90010 46547976
Platelet count decreased 101.34 15.53 278 47798 99746 46538240
Drug resistance 100.59 15.53 106 47970 17262 46620724
Peripheral swelling 94.97 15.53 23 48053 158048 46479938
Pain 92.83 15.53 223 47853 476725 46161261
Cardiotoxicity 92.05 15.53 67 48009 6655 46631331
Sepsis 89.83 15.53 326 47750 135688 46502298
Neurotoxicity 89.00 15.53 89 47987 13628 46624358
Weight increased 87.65 15.53 30 48046 164443 46473543
Oesophagitis 87.52 15.53 88 47988 13563 46624423
Headache 83.62 15.53 236 47840 478116 46159870
Pain in extremity 83.49 15.53 86 47990 258594 46379392
Hyponatraemia 82.89 15.53 261 47815 101071 46536915
Hypocalcaemia 81.18 15.53 118 47958 26667 46611319
Musculoskeletal stiffness 80.98 15.53 5 48071 97988 46539998
Hydronephrosis 79.88 15.53 68 48008 8477 46629509
Acute kidney injury 75.24 15.53 457 47619 235398 46402588
Tumour lysis syndrome 74.73 15.53 61 48015 7175 46630811
Hypophagia 74.53 15.53 119 47957 29187 46608799
Pulmonary embolism 74.00 15.53 263 47813 108322 46529664
Septic shock 71.06 15.53 173 47903 57720 46580266
Teratoma benign 70.74 15.53 16 48060 53 46637933
White blood cell count decreased 70.71 15.53 265 47811 111966 46526020
Injection site pain 69.64 15.53 13 48063 107139 46530847
Febrile bone marrow aplasia 69.09 15.53 57 48019 6805 46631181
Metastases to lymph nodes 68.69 15.53 56 48020 6575 46631411
Abdominal discomfort 68.59 15.53 35 48041 151130 46486856
Renal failure 67.28 15.53 263 47813 113331 46524655
Arthritis 66.84 15.53 3 48073 77313 46560673
Asthma 66.61 15.53 8 48068 91534 46546452
Neuropathy peripheral 66.12 15.53 225 47851 90668 46547318
Condition aggravated 63.82 15.53 96 47980 244956 46393030
Nasopharyngitis 63.63 15.53 40 48036 153958 46484028
Insomnia 62.61 15.53 47 48029 164877 46473109
Pruritus 61.14 15.53 97 47979 242255 46395731
Metastases to skin 59.89 15.53 29 48047 1351 46636635
Leukoencephalopathy 59.62 15.53 42 48034 3962 46634024
Electrolyte imbalance 58.28 15.53 80 47996 17146 46620840
Therapeutic product effect decreased 58.21 15.53 8 48068 82593 46555393
Arthropathy 57.84 15.53 9 48067 84691 46553295
Metastases to liver 57.49 15.53 85 47991 19500 46618486
Muscle spasms 56.59 15.53 28 48048 123085 46514901
Migraine 56.59 15.53 4 48072 70022 46567964
Metastases to breast 56.27 15.53 18 48058 269 46637717
Ascites 55.61 15.53 119 47957 36465 46601521
Cardiomyopathy 54.91 15.53 75 48001 15998 46621988
Depression 53.20 15.53 58 48018 170046 46467940
Gastrointestinal perforation 53.01 15.53 36 48040 3201 46634785
Diarrhoea 52.02 15.53 836 47240 558766 46079220
Oesophageal fistula 52.00 15.53 14 48062 109 46637877
Overdose 50.29 15.53 21 48055 101958 46536028
Polyneuropathy 50.25 15.53 61 48015 11583 46626403
Rash 49.70 15.53 194 47882 356318 46281668
Therapy partial responder 49.47 15.53 40 48036 4642 46633344
Contraindicated product administered 49.24 15.53 11 48065 79936 46558050
Palmar-plantar erythrodysaesthesia syndrome 49.21 15.53 81 47995 20370 46617616
Contusion 48.26 15.53 15 48061 87472 46550514
Abdominal pain 47.78 15.53 402 47674 229629 46408357
Myasthenia gravis crisis 47.55 15.53 17 48059 362 46637624
Large intestine perforation 47.01 15.53 48 48028 7532 46630454
Stomatitis 46.98 15.53 166 47910 68131 46569855
Renal tubular disorder 46.64 15.53 30 48046 2435 46635551
Swelling 46.58 15.53 36 48040 124475 46513511
Radiation skin injury 46.45 15.53 21 48055 836 46637150
Injection site erythema 46.32 15.53 10 48066 74417 46563569
Suicidal ideation 46.20 15.53 3 48073 56379 46581607
Ovarian cancer recurrent 46.16 15.53 22 48054 989 46636997
Renal tubular necrosis 45.84 15.53 56 48020 10703 46627283
Decreased appetite 45.83 15.53 349 47727 193487 46444499
Tinnitus 45.54 15.53 93 47983 27580 46610406
Feeling abnormal 44.49 15.53 38 48038 125022 46512964
Pleural effusion 44.26 15.53 186 47890 82766 46555220
Urticaria 44.21 15.53 34 48042 117858 46520128
Bronchitis 43.11 15.53 28 48048 105951 46532035
Gait disturbance 42.74 15.53 52 48024 145211 46492775
Deafness bilateral 41.79 15.53 22 48054 1225 46636761
Osteoarthritis 41.43 15.53 7 48069 62018 46575968
Mesenteric abscess 41.28 15.53 11 48065 82 46637904
Somnolence 41.02 15.53 61 48015 156460 46481526
Disease recurrence 40.26 15.53 70 48006 18401 46619585
Chemical peritonitis 39.96 15.53 11 48065 94 46637892
Blood creatinine increased 39.74 15.53 170 47906 76233 46561753
Sinusitis 39.73 15.53 45 48031 129723 46508263
Haemoglobin decreased 39.22 15.53 247 47829 128702 46509284
Large intestinal ulcer perforation 38.45 15.53 10 48066 67 46637919
Gastric perforation 38.12 15.53 21 48055 1281 46636705
Anastomotic leak 38.08 15.53 15 48061 421 46637565
Metastases to abdominal wall 37.95 15.53 10 48066 71 46637915
Loss of personal independence in daily activities 37.01 15.53 7 48069 57176 46580810
Inappropriate antidiuretic hormone secretion 36.86 15.53 58 48018 14044 46623942
Cystitis haemorrhagic 36.83 15.53 30 48046 3517 46634469
Embryonal rhabdomyosarcoma 36.83 15.53 7 48069 6 46637980
Nephritis bacterial 36.76 15.53 8 48068 21 46637965
Ureteric rupture 36.31 15.53 7 48069 7 46637979
Bicytopenia 35.87 15.53 22 48054 1642 46636344
Dizziness 35.79 15.53 205 47871 340209 46297777
Nasal abscess 35.65 15.53 11 48065 145 46637841
Encephalopathy 35.61 15.53 95 47981 33494 46604492
Metastases to peritoneum 35.36 15.53 26 48050 2622 46635364
Malignant transformation 35.31 15.53 13 48063 302 46637684
Performance status decreased 34.93 15.53 28 48048 3209 46634777
Melanoderma 34.92 15.53 11 48065 156 46637830
Neutropenic colitis 34.60 15.53 24 48052 2208 46635778
Wernicke's encephalopathy 34.19 15.53 8 48068 32 46637954
Metastases to bone 33.95 15.53 63 48013 17413 46620573
Dermatitis 33.81 15.53 56 48020 14152 46623834
Unevaluable event 33.67 15.53 4 48072 46171 46591815
Varicella zoster virus infection 33.55 15.53 24 48052 2319 46635667
Gastrointestinal fungal infection 33.46 15.53 12 48064 258 46637728
Haemophagocytic lymphohistiocytosis 33.26 15.53 42 48034 8300 46629686
Radiation injury 33.25 15.53 14 48062 468 46637518
Chloroma 33.13 15.53 11 48065 186 46637800
Hospitalisation 32.98 15.53 12 48064 63373 46574613
Cataract 32.95 15.53 4 48072 45411 46592575
Hypophosphataemia 32.45 15.53 39 48037 7328 46630658
Intentional product misuse 32.19 15.53 5 48071 47123 46590863
Cervix neoplasm 32.19 15.53 11 48065 204 46637782
Osteosarcoma 31.86 15.53 10 48066 140 46637846
Ovarian cancer 31.33 15.53 34 48042 5721 46632265
Abortion spontaneous 31.29 15.53 4 48072 43642 46594344
Nasal congestion 30.90 15.53 6 48070 48107 46589879
Injection site reaction 30.66 15.53 6 48070 47843 46590143
Anxiety 30.03 15.53 92 47984 181865 46456121
Axillary vein thrombosis 29.53 15.53 12 48064 366 46637620
Memory impairment 29.37 15.53 22 48054 77315 46560671
Respiratory symptom 29.18 15.53 21 48055 2049 46635937
Balance disorder 29.15 15.53 15 48061 64506 46573480
White blood cell count abnormal 29.14 15.53 31 48045 5101 46632885
Vesical fistula 28.99 15.53 8 48068 69 46637917
Ileus 28.97 15.53 52 48024 14012 46623974
Enteritis 28.52 15.53 35 48041 6720 46631266
Metastases to adrenals 28.46 15.53 14 48062 675 46637311
Herpes simplex encephalitis 28.43 15.53 11 48065 294 46637692
Cervix carcinoma 28.33 15.53 23 48053 2684 46635302
Influenza like illness 28.14 15.53 12 48064 57558 46580428
Stress 28.13 15.53 9 48067 51542 46586444
Radiation pneumonitis 28.08 15.53 17 48059 1240 46636746
Cervix cancer metastatic 28.02 15.53 7 48069 39 46637947
Sinus polyp 27.99 15.53 11 48065 307 46637679
Bladder perforation 27.92 15.53 9 48067 138 46637848
Malnutrition 27.86 15.53 51 48025 13952 46624034
Enterocolitis infectious 27.61 15.53 18 48058 1495 46636491
Cardiac tamponade 27.25 15.53 28 48048 4426 46633560
Injury 27.22 15.53 6 48070 44021 46593965
Wrong technique in product usage process 27.15 15.53 11 48065 54411 46583575
Fibromyalgia 26.98 15.53 3 48073 36460 46601526
Chronic obstructive pulmonary disease 26.63 15.53 13 48063 57620 46580366
Exposure during pregnancy 26.60 15.53 44 48032 108168 46529818
Venoocclusive liver disease 26.51 15.53 27 48049 4224 46633762
Thymus enlargement 26.47 15.53 8 48068 98 46637888
Alveolar soft part sarcoma 26.39 15.53 8 48068 99 46637887
Ovarian vein thrombosis 26.29 15.53 7 48069 52 46637934
Product quality issue 26.21 15.53 3 48073 35645 46602341
Renal impairment 26.14 15.53 148 47928 74224 46563762
Suicide attempt 26.07 15.53 12 48064 55024 46582962
Mobility decreased 26.04 15.53 15 48061 60579 46577407
Gastrooesophageal reflux disease 25.93 15.53 23 48053 74321 46563665
Metastases to meninges 25.91 15.53 19 48057 1908 46636078
Asthenia 25.91 15.53 457 47619 310618 46327368
Pericardial effusion 25.83 15.53 71 48005 25472 46612514
Osteosarcoma metastatic 25.65 15.53 6 48070 24 46637962
Haemolytic uraemic syndrome 25.55 15.53 21 48055 2493 46635493
Clostridium bacteraemia 25.34 15.53 9 48067 188 46637798
Malaise 25.21 15.53 219 47857 331013 46306973
Metastases to abdominal cavity 25.11 15.53 11 48065 406 46637580
Drug clearance decreased 25.09 15.53 15 48061 1069 46636917
Acoustic stimulation tests abnormal 24.92 15.53 8 48068 121 46637865
Cervix carcinoma recurrent 24.90 15.53 6 48070 28 46637958
Cardiac failure congestive 24.76 15.53 35 48041 91715 46546271
Aortic embolus 24.73 15.53 6 48070 29 46637957
Recall phenomenon 24.64 15.53 12 48064 566 46637420
Amputation stump pain 24.39 15.53 6 48070 31 46637955
Deep vein thrombosis 24.35 15.53 153 47923 79620 46558366
Myalgia 24.25 15.53 57 48019 123031 46514955
Hypoalbuminaemia 24.21 15.53 40 48036 10087 46627899
Neutrophil count abnormal 23.93 15.53 20 48056 2430 46635556
Burning sensation 23.80 15.53 8 48068 44403 46593583
Plasma cell leukaemia 23.76 15.53 15 48061 1178 46636808
Adverse drug reaction 23.76 15.53 8 48068 44354 46593632
Hiccups 23.62 15.53 15 48061 1191 46636795
Hepatic enzyme increased 23.29 15.53 30 48046 81757 46556229
Femur fracture 22.96 15.53 5 48071 36992 46600994
Vision blurred 22.94 15.53 29 48047 79679 46558307
Fluid retention 22.86 15.53 12 48064 51034 46586952
Stem cell transplant 22.82 15.53 17 48059 1749 46636237
Metastasis 22.65 15.53 25 48051 4287 46633699
Bacteraemia 22.56 15.53 47 48029 14132 46623854
Malignant peritoneal neoplasm 22.49 15.53 12 48064 687 46637299
Disseminated intravascular coagulation 22.46 15.53 56 48020 18949 46619037
Drug intolerance 22.41 15.53 77 47999 146972 46491014
Anti-Muellerian hormone level decreased 22.37 15.53 7 48069 97 46637889
Osteoporosis 22.32 15.53 7 48069 40601 46597385
Diffuse large B-cell lymphoma 22.26 15.53 29 48047 5909 46632077
Influenza 22.21 15.53 36 48040 89234 46548752
Enterococcal sepsis 22.17 15.53 15 48061 1325 46636661
Adrenocortical carcinoma 22.14 15.53 6 48070 48 46637938
Chronic kidney disease 22.06 15.53 92 47984 40779 46597207
Fistula of small intestine 21.74 15.53 9 48067 288 46637698
Vena cava thrombosis 21.73 15.53 18 48058 2161 46635825
Inappropriate schedule of product administration 21.62 15.53 21 48055 64992 46572994
Proctitis 21.54 15.53 16 48060 1639 46636347
Tumour haemorrhage 21.43 15.53 15 48061 1400 46636586
Vascular compression 21.38 15.53 7 48069 113 46637873
Oesophageal stenosis 21.33 15.53 20 48056 2829 46635157
Muscular weakness 21.06 15.53 39 48037 91805 46546181
Acquired gene mutation 21.02 15.53 11 48065 605 46637381
Acute myelomonocytic leukaemia 20.99 15.53 8 48068 205 46637781
Female genital tract fistula 20.98 15.53 21 48055 3218 46634768
Blood glucose increased 20.93 15.53 26 48050 71987 46565999
Pulmonary toxicity 20.92 15.53 25 48051 4668 46633318
Arteriospasm coronary 20.78 15.53 22 48054 3599 46634387
Oroticaciduria 20.75 15.53 4 48072 4 46637982
Diabetes mellitus 20.66 15.53 13 48063 50052 46587934
Neck pain 20.66 15.53 16 48060 55290 46582696
Blood magnesium decreased 20.57 15.53 39 48037 10953 46627033
Peripheral artery thrombosis 20.27 15.53 16 48060 1793 46636193
Salivary gland cancer 20.13 15.53 7 48069 137 46637849
Fatigue 20.04 15.53 476 47600 608221 46029765
Median nerve injury 19.99 15.53 5 48071 28 46637958
Incorrect dose administered 19.97 15.53 11 48065 45539 46592447
Peripheral sensory neuropathy 19.87 15.53 29 48047 6574 46631412
Peripheral ischaemia 19.86 15.53 24 48052 4535 46633451
Gastroenteritis radiation 19.85 15.53 10 48066 508 46637478
Metastases to pelvis 19.81 15.53 8 48068 240 46637746
Intestinal perforation 19.69 15.53 38 48038 10813 46627173
Failure to thrive 19.66 15.53 29 48047 6635 46631351
Maternal death affecting foetus 19.48 15.53 4 48072 7 46637979
VIth nerve paresis 19.45 15.53 6 48070 79 46637907
Medulloblastoma recurrent 19.32 15.53 6 48070 81 46637905
Purulent pericarditis 19.29 15.53 5 48071 33 46637953
Blister 19.24 15.53 11 48065 44620 46593366
Wheezing 19.24 15.53 16 48060 53370 46584616
Radiation oesophagitis 19.21 15.53 8 48068 260 46637726
Urogenital disorder 19.04 15.53 5 48071 35 46637951
Cytopenia 19.00 15.53 31 48045 7737 46630249
Leukaemic lymphoma 18.92 15.53 6 48070 87 46637899
Pain in jaw 18.75 15.53 8 48068 38364 46599622
Hypoglycaemia 18.73 15.53 17 48059 54332 46583654
Blood sodium decreased 18.69 15.53 57 48019 21669 46616317
Drug clearance increased 18.67 15.53 6 48070 91 46637895
Adverse event 18.60 15.53 6 48070 34178 46603808
Low cardiac output syndrome 18.47 15.53 8 48068 287 46637699
Refeeding syndrome 18.34 15.53 5 48071 41 46637945
Agitation 18.31 15.53 18 48058 55397 46582589
Radiation mucositis 18.13 15.53 5 48071 43 46637943
Gestational trophoblastic tumour 18.03 15.53 5 48071 44 46637942
Cerebral venous thrombosis 18.01 15.53 16 48060 2111 46635875
Central obesity 17.87 15.53 11 48065 826 46637160
Gastrointestinal necrosis 17.75 15.53 18 48058 2800 46635186
Pulmonary vascular disorder 17.75 15.53 8 48068 316 46637670
Transdifferentiation of neoplasm 17.74 15.53 4 48072 13 46637973
Emphysematous cholecystitis 17.64 15.53 3 48073 0 46637986
Tumour thrombosis 17.52 15.53 4 48072 14 46637972
Aorto-oesophageal fistula 17.52 15.53 4 48072 14 46637972
Sweat gland tumour 17.47 15.53 6 48070 113 46637873
Pelvic fluid collection 17.41 15.53 11 48065 865 46637121
Roseolovirus test positive 17.20 15.53 5 48071 53 46637933
Ovarian failure 17.15 15.53 12 48064 1120 46636866
Melanosis 17.10 15.53 4 48072 16 46637970
Myasthenic syndrome 17.09 15.53 7 48069 218 46637768
Therapy responder 17.05 15.53 8 48068 347 46637639
Mucosal erosion 17.05 15.53 13 48063 1385 46636601
Ovarian disorder 17.03 15.53 10 48066 689 46637297
Myocardial infarction 17.02 15.53 48 48028 97480 46540506
Lymphopenia 16.97 15.53 44 48032 15249 46622737
Multiple organ dysfunction syndrome 16.93 15.53 101 47975 51609 46586377
Eye pain 16.89 15.53 4 48072 27936 46610050
Hypoglossal nerve paresis 16.86 15.53 6 48070 126 46637860
Hallucination 16.77 15.53 16 48060 49935 46588051
Tumour invasion 16.73 15.53 6 48070 129 46637857
Aortitis 16.72 15.53 10 48066 713 46637273
Lip swelling 16.66 15.53 3 48073 25392 46612594
Tremor 16.65 15.53 62 48014 115577 46522409
Stent malfunction 16.64 15.53 5 48071 60 46637926
Marchiafava-Bignami disease 16.54 15.53 4 48072 19 46637967
Palpitations 16.54 15.53 47 48029 95212 46542774
Neoplasm recurrence 16.51 15.53 16 48060 2357 46635629
Wound 16.48 15.53 12 48064 42790 46595196
Drug interaction 16.46 15.53 132 47944 202962 46435024
Hypoaesthesia 16.30 15.53 65 48011 118804 46519182
Necrotising colitis 16.25 15.53 9 48067 555 46637431
Pregnancy 16.18 15.53 4 48072 27133 46610853
Multiple sclerosis 16.11 15.53 3 48073 24788 46613198
Sarcomatoid carcinoma 16.05 15.53 4 48072 22 46637964
Small fibre neuropathy 16.00 15.53 6 48070 147 46637839
Small cell lung cancer 15.87 15.53 13 48063 1536 46636450
Throat irritation 15.85 15.53 5 48071 28896 46609090
Genital abscess 15.81 15.53 6 48070 152 46637834
Gastric disorder 15.79 15.53 4 48072 26701 46611285
Radiation proctitis 15.56 15.53 3 48073 3 46637983
Osteoradionecrosis 15.56 15.53 6 48070 159 46637827
Malignant neoplasm of pleura 15.55 15.53 5 48071 76 46637910

FDA Adverse Event Reporting System (Male)

MedDRA adverse event termLikelihood ratioLikelihood ratio thresholdPatients taking drug having adverse eventPatients taking drug not having adverse eventPatients not taking drug having adverse eventPatients not taking drug not having adverse event
Febrile neutropenia 1347.76 13.11 1434 67773 105259 29778012
Neutropenia 818.36 13.11 1228 67979 127312 29755959
Mucosal inflammation 736.23 13.11 590 68617 29904 29853367
Thrombocytopenia 485.18 13.11 1013 68194 136031 29747240
Dehydration 360.89 13.11 846 68361 122693 29760578
Malignant neoplasm progression 340.82 13.11 604 68603 71683 29811588
Bone marrow failure 331.99 13.11 376 68831 29409 29853862
Leukopenia 316.12 13.11 508 68699 55651 29827620
Pancytopenia 305.33 13.11 633 68574 84419 29798852
Vomiting 278.73 13.11 1123 68084 218695 29664576
Stomatitis 266.32 13.11 377 68830 36902 29846369
Neutropenic sepsis 264.95 13.11 216 68991 11193 29872078
Nausea 241.46 13.11 1333 67874 295624 29587647
Haematotoxicity 241.29 13.11 160 69047 6010 29877261
Dysphagia 223.56 13.11 439 68768 56259 29827012
Disease progression 215.60 13.11 531 68676 79343 29803928
Acute myeloid leukaemia 205.13 13.11 230 68977 17776 29865495
Second primary malignancy 197.27 13.11 143 69064 6213 29877058
Off label use 189.66 13.11 1100 68107 248190 29635081
Neoplasm progression 183.08 13.11 217 68990 17806 29865465
Anaemia 183.04 13.11 955 68252 207037 29676234
Pulmonary embolism 175.50 13.11 485 68722 77650 29805621
Neutrophil count decreased 170.05 13.11 331 68876 42123 29841148
Product dose omission issue 157.29 13.11 15 69192 91616 29791655
Fall 156.88 13.11 115 69092 181757 29701514
Aortic thrombosis 156.09 13.11 59 69148 626 29882645
Arthralgia 136.20 13.11 72 69135 135719 29747552
Nephropathy toxic 135.25 13.11 144 69063 10495 29872776
Renal salt-wasting syndrome 132.23 13.11 36 69171 111 29883160
Myelodysplastic syndrome 119.62 13.11 180 69027 18598 29864673
Hyponatraemia 118.44 13.11 383 68824 66819 29816452
Tumour lysis syndrome 116.02 13.11 146 69061 12739 29870532
Pyrexia 115.99 13.11 1112 68095 293377 29589894
Oesophagitis 112.60 13.11 134 69073 11037 29872234
Headache 110.78 13.11 156 69051 182150 29701121
Decreased appetite 110.66 13.11 657 68550 149253 29734018
Myelosuppression 109.18 13.11 108 69099 7214 29876057
Diffuse large B-cell lymphoma refractory 108.26 13.11 47 69160 730 29882541
Drug interaction 107.71 13.11 185 69022 199383 29683888
Anastomotic leak 107.66 13.11 44 69163 583 29882688
Septic shock 107.13 13.11 357 68850 63250 29820021
Cardiotoxicity 103.36 13.11 84 69123 4330 29878941
Therapy partial responder 103.20 13.11 78 69129 3613 29879658
Cardiac failure congestive 100.09 13.11 35 69172 84372 29798899
Overdose 99.96 13.11 35 69172 84302 29798969
Hypomagnesaemia 98.54 13.11 154 69053 16444 29866827
Arterial thrombosis 95.46 13.11 52 69155 1354 29881917
White blood cell count decreased 92.69 13.11 412 68795 83535 29799736
Odynophagia 91.22 13.11 79 69128 4448 29878823
Depression 90.54 13.11 48 69159 90389 29792882
Aorto-oesophageal fistula 89.23 13.11 21 69186 27 29883244
Rhabdomyolysis 89.16 13.11 19 69188 63561 29819710
Gastric perforation 88.77 13.11 57 69150 2024 29881247
Product use in unapproved indication 87.72 13.11 370 68837 73323 29809948
Febrile bone marrow aplasia 86.38 13.11 100 69107 7997 29875274
Radiation skin injury 84.11 13.11 38 69169 652 29882619
Hypophagia 83.71 13.11 169 69038 22067 29861204
Tinnitus 82.90 13.11 140 69067 15948 29867323
Diffuse large B-cell lymphoma recurrent 81.17 13.11 54 69153 2038 29881233
Vena cava thrombosis 79.90 13.11 42 69165 1016 29882255
Weight increased 77.61 13.11 38 69169 74875 29808396
Metastases to lung 76.77 13.11 93 69114 7802 29875469
Inappropriate antidiuretic hormone secretion 76.34 13.11 112 69095 11310 29871961
Deafness 75.99 13.11 106 69101 10219 29873052
Rheumatoid arthritis 75.52 13.11 5 69202 41192 29842079
Acute kidney injury 75.00 13.11 963 68244 272879 29610392
Peripheral swelling 74.70 13.11 24 69183 61050 29822221
Ototoxicity 74.21 13.11 44 69163 1352 29881919
Peripheral artery thrombosis 73.34 13.11 52 69155 2180 29881091
Osteoradionecrosis 71.54 13.11 20 69187 70 29883201
Anxiety 69.66 13.11 63 69144 89808 29793463
Neutropenic colitis 68.79 13.11 50 69157 2180 29881091
Suicide attempt 68.62 13.11 4 69203 36693 29846578
Muscle spasms 68.52 13.11 32 69175 64806 29818465
Splenic infarction 68.15 13.11 46 69161 1779 29881492
Intentional product misuse 67.29 13.11 3 69204 34664 29848607
Death 66.80 13.11 518 68689 356765 29526506
Metastases to central nervous system 66.30 13.11 83 69124 7201 29876070
Platelet count decreased 65.70 13.11 445 68762 105684 29777587
Peripheral ischaemia 65.68 13.11 71 69136 5263 29878008
Bacterial translocation 64.84 13.11 24 69183 239 29883032
Hospitalisation 64.73 13.11 12 69195 44307 29838964
Sepsis 64.53 13.11 567 68640 145828 29737443
Suicidal ideation 64.41 13.11 5 69202 36109 29847162
Insomnia 63.73 13.11 73 69134 93263 29790008
Asthma 61.82 13.11 6 69201 36168 29847103
Myalgia 61.52 13.11 52 69155 76615 29806656
Hypokalaemia 60.46 13.11 253 68954 49939 29833332
Joint swelling 60.03 13.11 17 69190 46929 29836342
Oesophageal fistula 59.20 13.11 21 69186 183 29883088
Drug ineffective 58.79 13.11 504 68703 339883 29543388
Cytomegalovirus oesophagitis 58.74 13.11 22 69185 227 29883044
Musculoskeletal stiffness 58.64 13.11 7 69200 35874 29847397
General physical health deterioration 58.26 13.11 413 68794 99531 29783740
Nasopharyngitis 57.76 13.11 32 69175 58817 29824454
Dermatitis 56.09 13.11 81 69126 8061 29875210
Pain in extremity 55.92 13.11 106 69101 110115 29773156
Acute respiratory distress syndrome 55.89 13.11 149 69058 23323 29859948
Hypoglycaemia 55.68 13.11 24 69183 50957 29832314
Gastrointestinal toxicity 55.18 13.11 42 69165 1966 29881305
Blood pressure increased 55.04 13.11 51 69156 71877 29811394
Portal venous gas 53.39 13.11 22 69185 298 29882973
Hypocalcaemia 53.24 13.11 138 69069 21238 29862033
Hiccups 52.50 13.11 85 69122 9349 29873922
Pneumonitis 52.46 13.11 161 69046 27293 29855978
Osteosarcoma 52.45 13.11 19 69188 177 29883094
Aplasia 51.93 13.11 55 69152 3982 29879289
Cardiac disorder 51.83 13.11 14 69193 39879 29843392
Diarrhoea 51.61 13.11 1069 68138 333034 29550237
Renal failure 50.97 13.11 488 68719 128478 29754793
Pulmonary vascular disorder 50.37 13.11 22 69185 347 29882924
B-cell lymphoma recurrent 49.91 13.11 26 69181 617 29882654
Oesophagobronchial fistula 49.64 13.11 17 69190 132 29883139
Blood creatine phosphokinase increased 48.91 13.11 20 69187 43828 29839443
Electrolyte imbalance 48.86 13.11 92 69115 11408 29871863
Ameloblastoma 48.74 13.11 15 69192 79 29883192
Hepatitis B 48.71 13.11 65 69142 6007 29877264
Hypertension 48.36 13.11 133 69074 121221 29762050
Dizziness 48.34 13.11 259 68948 194650 29688621
Pruritus 48.26 13.11 128 69079 118076 29765195
Tremor 48.20 13.11 62 69145 75301 29807970
Aggression 47.86 13.11 13 69194 36894 29846377
Oesophageal stenosis 47.71 13.11 35 69172 1548 29881723
Hallucination 47.67 13.11 27 69180 49032 29834239
Metastases to liver 47.50 13.11 93 69114 11872 29871399
Malignant transformation 47.38 13.11 26 69181 687 29882584
Tumour necrosis 46.77 13.11 30 69177 1063 29882208
Vision blurred 46.76 13.11 19 69188 41797 29841474
Radiation pneumonitis 46.76 13.11 38 69169 1958 29881313
Inappropriate schedule of product administration 46.17 13.11 17 69190 39711 29843560
Renal infarct 45.89 13.11 30 69177 1099 29882172
Condition aggravated 45.84 13.11 164 69043 137702 29745569
Colitis 45.77 13.11 166 69041 30654 29852617
Intestinal ischaemia 45.18 13.11 67 69140 6830 29876441
Injection site pain 44.71 13.11 8 69199 30302 29852969
Deafness neurosensory 44.69 13.11 40 69167 2353 29880918
Coronary artery disease 44.64 13.11 30 69177 49682 29833589
Salivary gland cancer 44.63 13.11 18 69189 230 29883041
Azoospermia 44.44 13.11 21 69186 401 29882870
Deep vein thrombosis 43.75 13.11 264 68943 60237 29823034
Gait disturbance 43.34 13.11 66 69141 74711 29808560
Feeling abnormal 42.53 13.11 41 69166 56715 29826556
Atypical haemolytic uraemic syndrome 42.51 13.11 14 69193 95 29883176
Somnolence 42.43 13.11 101 69106 96662 29786609
Disease recurrence 42.26 13.11 98 69109 14063 29869208
Metastases to lymph nodes 42.22 13.11 49 69158 3928 29879343
Radiation mucositis 42.13 13.11 14 69193 98 29883173
Myocardial infarction 40.73 13.11 151 69056 125474 29757797
Influenza 40.59 13.11 25 69182 43373 29839898
Carotid artery thrombosis 40.59 13.11 19 69188 355 29882916
Bacteraemia 40.35 13.11 102 69105 15458 29867813
Urticaria 40.27 13.11 40 69167 54566 29828705
Mobility decreased 40.27 13.11 6 69201 25993 29857278
Wheezing 39.92 13.11 11 69196 30927 29852344
Chemotherapy 39.54 13.11 21 69186 519 29882752
Angioedema 39.47 13.11 15 69192 34369 29848902
Pneumatosis intestinalis 38.85 13.11 39 69168 2651 29880620
Embolism 38.79 13.11 63 69144 6946 29876325
Neoplasm recurrence 38.46 13.11 33 69174 1834 29881437
Blood stem cell transplant failure 38.27 13.11 19 69188 406 29882865
Therapeutic product effect decreased 38.16 13.11 10 69197 29066 29854205
Palmar-plantar erythrodysaesthesia syndrome 38.06 13.11 97 69110 14773 29868498
Neuropathy peripheral 38.03 13.11 286 68921 70189 29813082
Tracheo-oesophageal fistula 38.02 13.11 19 69188 412 29882859
Nephrolithiasis 37.80 13.11 6 69201 24804 29858467
Foetal exposure during pregnancy 37.72 13.11 19 69188 36852 29846419
Chloroma 37.41 13.11 19 69188 427 29882844
Radiation oesophagitis 37.38 13.11 18 69189 359 29882912
Large intestine perforation 37.33 13.11 65 69142 7586 29875685
Heart rate decreased 37.17 13.11 3 69204 20991 29862280
Tumour haemorrhage 37.15 13.11 37 69170 2491 29880780
Wrong technique in product usage process 36.76 13.11 13 69194 31142 29852129
Adverse drug reaction 36.65 13.11 5 69202 23140 29860131
Drug hypersensitivity 36.42 13.11 64 69143 68455 29814816
Tumour perforation 35.81 13.11 16 69191 267 29883004
Enteritis 35.79 13.11 59 69148 6586 29876685
Neurosensory hypoacusis 35.51 13.11 7 69200 0 29883271
Memory impairment 35.34 13.11 21 69186 37153 29846118
Arthritis 34.79 13.11 7 69200 24394 29858877
Renal tubular disorder 34.77 13.11 50 69157 4956 29878315
Abdominal discomfort 34.55 13.11 37 69170 48754 29834517
Pulmonary arteriopathy 34.55 13.11 11 69196 66 29883205
Electrocardiogram QT prolonged 34.41 13.11 20 69187 35815 29847456
Testicular germ cell cancer metastatic 34.41 13.11 11 69196 67 29883204
Alopecia 34.03 13.11 110 69097 19165 29864106
Renal impairment 33.43 13.11 319 68888 83865 29799406
Influenza like illness 33.23 13.11 9 69198 25596 29857675
Rash 32.61 13.11 285 68922 191604 29691667
Confusional state 32.38 13.11 181 69026 134653 29748618
Recall phenomenon 32.16 13.11 19 69188 580 29882691
Arterial occlusive disease 32.02 13.11 43 69164 3997 29879274
Lymphopenia 31.77 13.11 84 69123 13079 29870192
Dyskinesia 31.69 13.11 6 69201 21828 29861443
Empyema 31.68 13.11 36 69171 2820 29880451
Unevaluable event 31.59 13.11 17 69190 31768 29851503
Injury 31.48 13.11 6 69201 21725 29861546
Balance disorder 31.47 13.11 23 69184 36470 29846801
Cerebral venous sinus thrombosis 31.39 13.11 15 69192 294 29882977
Erectile dysfunction 30.93 13.11 3 69204 18099 29865172
International normalised ratio increased 30.79 13.11 39 69168 47700 29835571
Oesophageal perforation 30.75 13.11 17 69190 456 29882815
Osteosarcoma recurrent 30.33 13.11 8 69199 21 29883250
Blood sodium decreased 30.29 13.11 93 69114 15763 29867508
Hypophosphataemia 30.23 13.11 62 69145 8183 29875088
Liver function test abnormal 30.11 13.11 17 69190 30933 29852338
Respiratory failure 29.99 13.11 360 68847 100282 29782989
Mantle cell lymphoma recurrent 29.71 13.11 16 69191 407 29882864
Cataract 29.64 13.11 7 69200 21828 29861443
Blood glucose increased 29.60 13.11 61 69146 61469 29821802
Thrombotic microangiopathy 29.53 13.11 63 69144 8547 29874724
Chronic obstructive pulmonary disease 29.42 13.11 38 69169 46088 29837183
Primitive neuroectodermal tumour 29.38 13.11 10 69197 76 29883195
Leukoencephalopathy 29.32 13.11 41 69166 3961 29879310
Malaise 29.24 13.11 246 68961 166716 29716555
Bronchial fistula 29.22 13.11 12 69195 161 29883110
Acquired gene mutation 29.11 13.11 23 69184 1138 29882133
Osteoarthritis 28.96 13.11 4 69203 18345 29864926
Pancreatitis 28.95 13.11 25 69182 36465 29846806
Depressed mood 28.64 13.11 3 69204 17026 29866245
Interstitial lung disease 28.47 13.11 237 68970 59960 29823311
Metastatic gastric cancer 28.38 13.11 12 69195 174 29883097
Muscular weakness 28.23 13.11 66 69141 63579 29819692
Bicytopenia 28.16 13.11 27 69180 1735 29881536
Cerebral ischaemia 28.09 13.11 51 69156 6149 29877122
Hypoacusis 28.02 13.11 84 69123 14055 29869216
Product prescribing error 28.00 13.11 3 69204 16730 29866541
Angina pectoris 27.60 13.11 17 69190 29501 29853770
Metastasis 27.52 13.11 36 69171 3262 29880009
Incorrect dose administered 27.28 13.11 20 69187 31666 29851605
Blood pressure fluctuation 27.20 13.11 4 69203 17499 29865772
Toxicity to various agents 26.73 13.11 271 68936 176912 29706359
Prostate cancer 26.59 13.11 11 69196 23946 29859325
Enterocolitis 26.57 13.11 52 69155 6635 29876636
Abnormal behaviour 26.51 13.11 13 69194 25610 29857661
Disseminated intravascular coagulation 26.09 13.11 111 69096 22060 29861211
Papillary thyroid cancer 26.00 13.11 17 69190 623 29882648
Emotional distress 25.94 13.11 3 69204 15762 29867509
Serotonin syndrome 25.79 13.11 5 69202 17886 29865385
Product quality issue 25.52 13.11 6 69201 18768 29864503
Extravasation 25.48 13.11 26 69181 1802 29881469
Hepatic candidiasis 25.41 13.11 8 69199 46 29883225
Blindness cortical 25.36 13.11 13 69194 298 29882973
Oesophageal carcinoma 25.27 13.11 34 69173 3167 29880104
Refractory cancer 25.13 13.11 10 69197 123 29883148
Nasal congestion 25.11 13.11 6 69201 18560 29864711
Retinal toxicity 25.01 13.11 14 69193 385 29882886
Gout 24.62 13.11 5 69202 17310 29865961
Road traffic accident 24.13 13.11 5 69202 17066 29866205
Arteriospasm coronary 24.09 13.11 30 69177 2588 29880683
Necrosis 23.98 13.11 43 69164 5136 29878135
Fluid retention 23.93 13.11 14 69193 24984 29858287
Morphoea 23.91 13.11 10 69197 141 29883130
Oedema peripheral 23.83 13.11 145 69062 105687 29777584
Gait inability 23.75 13.11 7 69200 18834 29864437
Soft tissue disorder 23.70 13.11 16 69191 619 29882652
Chest discomfort 23.69 13.11 43 69164 45437 29837834
Flagellate dermatitis 23.55 13.11 6 69201 13 29883258
Dermatitis acneiform 23.53 13.11 45 69162 5644 29877627
Irritability 23.39 13.11 12 69195 23038 29860233
Teratoma 23.24 13.11 6 69201 14 29883257
Blood HIV RNULL increased 23.20 13.11 22 69185 1394 29881877
Bradycardia 23.06 13.11 76 69131 65450 29817821
Adenocarcinoma gastric 23.01 13.11 20 69187 1131 29882140
Pneumothorax 23.01 13.11 86 69121 16107 29867164
Cerebral infarction 22.96 13.11 121 69086 26252 29857019
Contusion 22.96 13.11 23 69184 31257 29852014
Pulmonary toxicity 22.86 13.11 39 69168 4477 29878794
Refeeding syndrome 22.73 13.11 7 69200 37 29883234
Sedation 22.72 13.11 5 69202 16368 29866903
Accidental overdose 22.66 13.11 7 69200 18268 29865003
Necrosis ischaemic 22.51 13.11 11 69196 227 29883044
Plasma cell leukaemia 22.49 13.11 18 69189 907 29882364
Superior mesenteric artery syndrome 22.33 13.11 8 69199 72 29883199
Therapy cessation 22.31 13.11 4 69203 15133 29868138
Radiation injury 22.16 13.11 14 69193 483 29882788
Pain 22.10 13.11 274 68933 172367 29710904
Extremity necrosis 22.09 13.11 23 69184 1632 29881639
Herpes zoster 22.00 13.11 22 69185 29921 29853350
Blood cholesterol increased 21.96 13.11 6 69201 16964 29866307
Sleep disorder 21.66 13.11 15 69192 24464 29858807
Carotid artery dissection 21.57 13.11 9 69198 126 29883145
Procedural vomiting 21.51 13.11 9 69198 127 29883144
Blood creatinine increased 21.44 13.11 313 68894 91062 29792209
Metastases to peritoneum 21.44 13.11 22 69185 1535 29881736
Diabetes mellitus 21.43 13.11 40 69167 41825 29841446
Hypochloraemia 21.34 13.11 15 69192 620 29882651
Gastrooesophageal reflux disease 21.16 13.11 26 69181 32229 29851042
Drug clearance decreased 21.15 13.11 20 69187 1263 29882008
Embolism arterial 20.89 13.11 14 69193 535 29882736
Haematoma 20.77 13.11 15 69192 23938 29859333
Product administration error 20.76 13.11 4 69203 14373 29868898
Iliac artery occlusion 20.72 13.11 9 69198 140 29883131
Lactic acidosis 20.65 13.11 25 69182 31188 29852083
Vascular injury 20.52 13.11 11 69196 277 29882994
Gastrointestinal ischaemia 20.48 13.11 10 69197 206 29883065
Granulocyte count decreased 20.44 13.11 15 69192 664 29882607
Neurotoxicity 20.41 13.11 72 69135 13110 29870161
Back pain 20.35 13.11 146 69061 102450 29780821
Oral candidiasis 20.28 13.11 64 69143 11007 29872264
Cell-mediated immune deficiency 20.27 13.11 6 69201 27 29883244
Metastases to skin 20.26 13.11 12 69195 368 29882903
Blood glucose decreased 20.24 13.11 3 69204 13050 29870221
Coronary artery thrombosis 20.24 13.11 25 69182 2139 29881132
Drug intolerance 20.05 13.11 47 69160 45244 29838027
Non-small cell lung cancer 19.93 13.11 33 69174 3697 29879574
Campylobacter test positive 19.92 13.11 6 69201 29 29883242
Adrenocortical carcinoma 19.92 13.11 6 69201 29 29883242
Cholelithiasis 19.83 13.11 11 69196 20214 29863057
Small cell lung cancer 19.68 13.11 23 69184 1857 29881414
Cerebral venous thrombosis 19.62 13.11 14 69193 593 29882678
Full blood count decreased 19.52 13.11 6 69201 15711 29867560
Seminoma 19.48 13.11 10 69197 230 29883041
Localised infection 19.46 13.11 4 69203 13733 29869538
Drug resistance 19.37 13.11 95 69112 20038 29863233
Hypoalbuminaemia 19.30 13.11 63 69144 11029 29872242
Progressive multifocal leukoencephalopathy 19.25 13.11 55 69152 8958 29874313
Venous thrombosis 19.18 13.11 30 69177 3204 29880067
Transient ischaemic attack 19.11 13.11 18 69189 25182 29858089
Haematochezia 19.06 13.11 31 69176 34191 29849080
Transitional cell carcinoma recurrent 18.99 13.11 5 69202 13 29883258
Laryngeal pain 18.99 13.11 28 69179 2839 29880432
Oesophageal pain 18.90 13.11 15 69192 747 29882524
Wound 18.89 13.11 3 69204 12399 29870872
Medulloblastoma recurrent 18.89 13.11 7 69200 70 29883201
Pharyngeal inflammation 18.88 13.11 11 69196 327 29882944
Transformation to acute myeloid leukaemia 18.83 13.11 14 69193 632 29882639
Agitation 18.83 13.11 63 69144 54010 29829261
Eczema 18.72 13.11 4 69203 13365 29869906
Dropped head syndrome 18.62 13.11 7 69200 73 29883198
Myoclonus 18.60 13.11 4 69203 13308 29869963
COVID-19 18.60 13.11 9 69198 17869 29865402
Visceral venous thrombosis 18.47 13.11 5 69202 15 29883256
Pleural mesothelioma malignant 18.46 13.11 7 69200 75 29883196
Procedural nausea 18.46 13.11 7 69200 75 29883196
Haemoptysis 18.40 13.11 129 69078 30949 29852322
Intestinal infarction 18.35 13.11 13 69194 544 29882727
Mucosal toxicity 18.10 13.11 9 69198 193 29883078
Speech disorder 18.01 13.11 18 69189 24494 29858777
Pleural effusion 17.88 13.11 255 68952 73811 29809460
Sinusitis 17.84 13.11 31 69176 33314 29849957
Hyperlipidaemia 17.84 13.11 5 69202 13902 29869369
Chromaturia 17.75 13.11 5 69202 13860 29869411
Ureteric dilatation 17.72 13.11 8 69199 137 29883134
Trigeminal nerve paresis 17.53 13.11 4 69203 4 29883267
Dermatitis diaper 17.51 13.11 10 69197 286 29882985
Fanconi syndrome 17.40 13.11 21 69186 1754 29881517
Granulocyte-colony stimulating factor level increased 17.36 13.11 5 69202 20 29883251
Human chorionic gonadotropin increased 17.36 13.11 5 69202 20 29883251
Type 2 diabetes mellitus 17.28 13.11 5 69202 13617 29869654
Blood creatinine 17.26 13.11 6 69201 49 29883222
Palpitations 17.25 13.11 32 69175 33541 29849730
Performance status decreased 17.24 13.11 32 69175 3925 29879346
Chemotherapeutic drug level increased 17.11 13.11 9 69198 218 29883053
Cerebrovascular accident 16.94 13.11 118 69089 83359 29799912
Blood lactate dehydrogenase increased 16.90 13.11 93 69114 20508 29862763
Peritonitis bacterial 16.78 13.11 3 69204 11375 29871896
Sleep apnoea syndrome 16.77 13.11 9 69198 16848 29866423
Psychotic disorder 16.75 13.11 15 69192 21500 29861771
Gingivitis ulcerative 16.75 13.11 6 69201 54 29883217
Gastrointestinal perforation 16.71 13.11 30 69177 3586 29879685
Loss of consciousness 16.70 13.11 111 69096 79264 29804007
Thrombocytosis 16.65 13.11 29 69178 3384 29879887
Eosinophilia 16.60 13.11 16 69191 22144 29861127
Lymphangiosis carcinomatosa 16.59 13.11 15 69192 894 29882377
Withdrawal syndrome 16.52 13.11 3 69204 11247 29872024
Tumour thrombosis 16.46 13.11 6 69201 57 29883214
Lung adenocarcinoma 16.44 13.11 32 69175 4067 29879204
Blood magnesium decreased 16.41 13.11 38 69169 5445 29877826
Swelling face 16.25 13.11 15 69192 21189 29862082
Deafness bilateral 16.20 13.11 16 69191 1066 29882205
Monocyte count decreased 16.17 13.11 14 69193 788 29882483
Upper respiratory tract infection 16.15 13.11 24 69183 27452 29855819
Hepatitis B reactivation 16.11 13.11 26 69181 2851 29880420
Burning sensation 16.09 13.11 9 69198 16465 29866806
Metastases to bone 16.04 13.11 54 69153 9604 29873667
Urinary tract infection 16.01 13.11 102 69105 73557 29809714
Delusion 15.97 13.11 4 69203 11985 29871286
Ganglioneuroma 15.91 13.11 4 69203 8 29883263
Laryngeal cancer stage IV 15.91 13.11 4 69203 8 29883263
Hot flush 15.88 13.11 7 69200 14673 29868598
Gastrointestinal anastomotic leak 15.75 13.11 10 69197 348 29882923
Peripheral sensory neuropathy 15.63 13.11 39 69168 5862 29877409
Loss of personal independence in daily activities 15.61 13.11 16 69191 21519 29861752
Wound evisceration 15.60 13.11 7 69200 118 29883153
Testicular cancer metastatic 15.60 13.11 6 69201 67 29883204
Osteosarcoma metastatic 15.60 13.11 4 69203 9 29883262
Oesophageal squamous cell carcinoma 15.57 13.11 10 69197 355 29882916
Rib fracture 15.54 13.11 5 69202 12715 29870556
Bronchitis 15.47 13.11 43 69164 39082 29844189
Disturbance in attention 15.42 13.11 17 69190 22112 29861159
Subcutaneous emphysema 15.41 13.11 15 69192 982 29882289
Fistula of small intestine 15.40 13.11 10 69197 362 29882909
Swelling 15.39 13.11 38 69169 35937 29847334
Myelitis transverse 15.37 13.11 15 69192 985 29882286
Choriocarcinoma 15.30 13.11 5 69202 33 29883238
Diabetic ketoacidosis 15.23 13.11 9 69198 15977 29867294
Pharyngeal stenosis 15.22 13.11 3 69204 0 29883271
Testicular malignant teratoma 15.22 13.11 3 69204 0 29883271
Hyperammonaemic encephalopathy 15.19 13.11 20 69187 1824 29881447
Sarcoma 15.18 13.11 10 69197 371 29882900
Hyperhidrosis 15.04 13.11 92 69115 66998 29816273
Dementia 15.04 13.11 5 69202 12456 29870815
Traumatic lung injury 15.03 13.11 16 69191 1165 29882106
Laboratory test abnormal 15.02 13.11 11 69196 17431 29865840
Dysstasia 15.00 13.11 3 69204 10502 29872769
Diffuse large B-cell lymphoma 14.99 13.11 46 69161 7795 29875476
No adverse event 14.99 13.11 11 69196 17408 29865863
Fatigue 14.92 13.11 598 68609 320075 29563196
Visual impairment 14.78 13.11 30 69177 30408 29852863
Neutrophil count abnormal 14.69 13.11 17 69190 1358 29881913
Blood triglycerides increased 14.67 13.11 7 69200 14010 29869261
Hypersomnia 14.64 13.11 4 69203 11312 29871959
Peritonitis 14.63 13.11 92 69115 21283 29861988
Hepatic enzyme increased 14.63 13.11 35 69172 33459 29849812
Hypoaesthesia 14.57 13.11 70 69137 54160 29829111
Plasmacytoma 14.44 13.11 27 69180 3329 29879942
Candida infection 14.43 13.11 72 69135 15290 29867981
Injection site erythema 14.34 13.11 7 69200 13827 29869444
Blister 14.29 13.11 16 69191 20667 29862604
Enterococcal bacteraemia 14.29 13.11 17 69190 1399 29881872
Hip fracture 14.27 13.11 4 69203 11120 29872151
Anastomotic complication 14.26 13.11 9 69198 310 29882961
Accidental exposure to product 14.22 13.11 3 69204 10112 29873159
Nasopharyngeal cancer 14.21 13.11 7 69200 147 29883124
Hemianopia 14.19 13.11 12 69195 654 29882617
Candida sepsis 14.18 13.11 15 69192 1084 29882187
Blastic plasmacytoid dendritic cell neoplasia 14.07 13.11 6 69201 89 29883182
Basal cell carcinoma 14.01 13.11 10 69197 16058 29867213
Focal nodular hyperplasia 14.00 13.11 7 69200 152 29883119
Treatment noncompliance 13.95 13.11 23 69184 25230 29858041
Gene mutation 13.92 13.11 13 69194 808 29882463
Suture related complication 13.88 13.11 7 69200 155 29883116
Hyperglycaemic hyperosmolar nonketotic syndrome 13.84 13.11 14 69193 960 29882311
Human herpesvirus 8 infection 13.83 13.11 12 69195 677 29882594
Bone sarcoma 13.83 13.11 6 69201 93 29883178
Haemoperitoneum 13.82 13.11 17 69190 1448 29881823
Eye pain 13.77 13.11 5 69202 11784 29871487
Short stature 13.76 13.11 5 69202 47 29883224
Movement disorder 13.75 13.11 3 69204 9880 29873391
Fistula 13.72 13.11 34 69173 5088 29878183
Blood pressure systolic increased 13.72 13.11 9 69198 15101 29868170
Penile vein thrombosis 13.70 13.11 4 69203 17 29883254
Therapeutic embolisation 13.69 13.11 9 69198 333 29882938
Gastrointestinal haemorrhage 13.67 13.11 125 69082 83321 29799950
Platelet transfusion 13.56 13.11 14 69193 984 29882287
Blood culture positive 13.54 13.11 33 69174 4886 29878385
Cholestasis 13.52 13.11 23 69184 24927 29858344
Decorticate posture 13.51 13.11 4 69203 18 29883253
Scleroderma 13.50 13.11 16 69191 1311 29881960
Cellulitis 13.39 13.11 59 69148 46725 29836546
Anaplastic lymphoma kinase gene mutation 13.33 13.11 6 69201 102 29883169
Tracheal stenosis 13.29 13.11 7 69200 170 29883101
Pulmonary necrosis 13.27 13.11 9 69198 351 29882920
Oral pain 13.21 13.11 50 69157 9419 29873852
Ventricular extrasystoles 13.17 13.11 5 69202 11469 29871802
Torulopsis infection 13.17 13.11 4 69203 20 29883251
Diaphragmatic rupture 13.17 13.11 4 69203 20 29883251
Presbyacusis 13.15 13.11 3 69204 3 29883268
Haemorrhagic tumour necrosis 13.15 13.11 3 69204 3 29883268
Mastoid effusion 13.15 13.11 3 69204 3 29883268
Gastropleural fistula 13.15 13.11 3 69204 3 29883268
Thymic cancer metastatic 13.15 13.11 3 69204 3 29883268

Pharmacologic Action:

SourceCodeDescription
ATC L01XA01 ANTINEOPLASTIC AND IMMUNOMODULATING AGENTS
ANTINEOPLASTIC AGENTS
OTHER ANTINEOPLASTIC AGENTS
Platinum compounds
FDA EXT N0000175073 Platinum-containing Compounds
FDA EPC N0000175413 Platinum-based Drug
MeSH PA D000970 Antineoplastic Agents
MeSH PA D003432 Cross-Linking Reagents
MeSH PA D007202 Indicators and Reagents
MeSH PA D011838 Radiation-Sensitizing Agents
CHEBI has role CHEBI:25435 mutagens
CHEBI has role CHEBI:35610 cytostatic
CHEBI has role CHEBI:47868 photosensitising agent
CHEBI has role CHEBI:50684 cross-linking reagents
CHEBI has role CHEBI:50902 genotoxic agent
CHEBI has role CHEBI:61015 nephrotoxins

Drug Use (View source of the data)

DiseaseRelationSNOMED_IDDOID
Malignant tumor of ovary indication 363443007 DOID:2394
Ovarian Germ Cell Tumor Carcinoma indication
Testicular Germ Cell Tumor indication
Invasive Bladder Malignancy indication

Acid dissociation constants calculated using MoKa v3.0.0

None

Orange Book patent data (new drug applications)

None

Orange Book exclusivity data (new drug applications)

None

Bioactivity Summary:

TargetClassPharosUniProtActionTypeActivity value
(-log[M])
Mechanism
action
Bioact sourceMoA source
Epidermal growth factor receptor Kinase IC50 5.58 DRUG MATRIX
Tyrosine-protein kinase Lck Kinase IC50 4.64 DRUG MATRIX
Tyrosine-protein kinase Fyn Kinase IC50 5.32 DRUG MATRIX
C-X-C chemokine receptor type 2 GPCR Ki 5.02 DRUG MATRIX
Thromboxane-A synthase Enzyme IC50 5.03 DRUG MATRIX
C-C chemokine receptor type 2 GPCR Ki 5.15 DRUG MATRIX
Mitogen-activated protein kinase 3 Kinase IC50 5.33 DRUG MATRIX
Melanocortin receptor 5 GPCR Ki 5.22 DRUG MATRIX
Multidrug resistance-associated protein 5 Transporter WOMBAT-PK
Multidrug resistance-associated protein 6 Transporter WOMBAT-PK
Canalicular multispecific organic anion transporter 1 Transporter WOMBAT-PK
D(3) dopamine receptor GPCR Ki 5.95 CHEMBL
Adenosine receptor A3 GPCR Ki 5.62 DRUG MATRIX
Muscarinic acetylcholine receptor M5 GPCR Ki 5.37 CHEMBL
DNA DNA OTHER CHEMBL CHEMBL
Sodium/potassium-transporting ATPase subunit alpha-2 Ion channel IC50 5.03 DRUG MATRIX

External reference:

IDSource
D00275 KEGG_DRUG
4018139 VUID
N0000146476 NUI
4018139 VANDF
C0008838 UMLSCUI
CHEBI:27899 CHEBI
CPT PDB_CHEM_ID
CHEMBL11359 ChEMBL_ID
CHEMBL1386 ChEMBL_ID
CHEMBL2068237 ChEMBL_ID
DB00515 DRUGBANK_ID
D002945 MESH_DESCRIPTOR_UI
5702198 PUBCHEM_CID
5343 IUPHAR_LIGAND_ID
4426 INN_ID
Q20Q21Q62J UNII
2555 RXNORM
31747 MMSL
4456 MMSL
d00195 MMSL
002641 NDDF
387318005 SNOMEDCT_US
57066004 SNOMEDCT_US

Pharmaceutical products:

ProductCategoryIngredientsNDCFormQuantityRouteMarketingLabel
CISplatin HUMAN PRESCRIPTION DRUG LABEL 1 0143-9504 INJECTION 1 mg INTRAVENOUS ANDA 19 sections
CISplatin HUMAN PRESCRIPTION DRUG LABEL 1 0143-9505 INJECTION 1 mg INTRAVENOUS ANDA 19 sections
Cisplatin HUMAN PRESCRIPTION DRUG LABEL 1 0703-5747 INJECTION, SOLUTION 50 mg INTRAVENOUS ANDA 21 sections
Cisplatin HUMAN PRESCRIPTION DRUG LABEL 1 0703-5748 INJECTION, SOLUTION 100 mg INTRAVENOUS ANDA 21 sections
Cisplatin HUMAN PRESCRIPTION DRUG LABEL 1 16729-288 INJECTION 1 mg INTRAVENOUS ANDA 26 sections
CISplatin HUMAN PRESCRIPTION DRUG LABEL 1 44567-509 INJECTION, SOLUTION 1 mg INTRAVENOUS NDA 19 sections
CISplatin HUMAN PRESCRIPTION DRUG LABEL 1 44567-510 INJECTION, SOLUTION 1 mg INTRAVENOUS NDA 19 sections
CISplatin HUMAN PRESCRIPTION DRUG LABEL 1 44567-511 INJECTION, SOLUTION 1 mg INTRAVENOUS NDA 19 sections
Cisplatin HUMAN PRESCRIPTION DRUG LABEL 1 44567-530 INJECTION, POWDER, LYOPHILIZED, FOR SOLUTION 1 mg INTRAVENOUS NDA 26 sections
Cisplatin HUMAN PRESCRIPTION DRUG LABEL 1 63323-103 INJECTION, SOLUTION 1 mg INTRAVENOUS ANDA 13 sections
Cisplatin HUMAN PRESCRIPTION DRUG LABEL 1 68001-283 INJECTION 1 mg INTRAVENOUS ANDA 26 sections
CISPLATIN Human Prescription Drug Label 1 68083-162 INJECTION, SOLUTION 1 mg INTRAVENOUS ANDA 13 sections
CISPLATIN Human Prescription Drug Label 1 68083-163 INJECTION, SOLUTION 1 mg INTRAVENOUS ANDA 13 sections
Cisplatin HUMAN PRESCRIPTION DRUG LABEL 1 70860-206 INJECTION, SOLUTION 1 mg INTRAVENOUS ANDA 21 sections