cisplatin ๐Ÿถ Veterinary Use | Indications/Contra | FAERs-F | FAERs-M | Orange Bk | BioActivity |

Stem definitionDrug idCAS RN
antineoplastic agents, platinum derivatives 4392 15663-27-1

Description:

MoleculeDescription

Synonyms:

  • cisplatin
  • platinum diamminodichloride
  • cis-Platinum
An inorganic and water-soluble platinum complex. After undergoing hydrolysis, it reacts with DNA to produce both intra and interstrand crosslinks. These crosslinks appear to impair replication and transcription of DNA. The cytotoxicity of cisplatin correlates with cellular arrest in the G2 phase of the cell cycle.
  • Molecular weight: 300.05
  • Formula: Cl2H6N2Pt
  • CLOGP:
  • LIPINSKI: None
  • HAC: None
  • HDO: None
  • TPSA:
  • ALOGS:
  • ROTB: None

Drug dosage:

None

ADMET properties:

PropertyValueReference
BDDCS (Biopharmaceutical Drug Disposition Classification System) 1 Benet LZ, Broccatelli F, Oprea TI
S (Water solubility) 2.53 mg/mL Benet LZ, Broccatelli F, Oprea TI
EoM (Fraction excreted unchanged in urine) 2.30 % Benet LZ, Broccatelli F, Oprea TI
MRTD (Maximum Recommended Therapeutic Daily Dose) 4.75 ยตM/kg/day Contrera JF, Matthews EJ, Kruhlak NL, Benz RD

Approvals:

DateAgencyCompanyOrphan
Dec. 19, 1978 FDA HQ SPCLT PHARMA

FDA Adverse Event Reporting System (Female)

MedDRA adverse event termLikelihood ratioLikelihood ratio thresholdPatients taking drug having adverse eventPatients taking drug not having adverse eventPatients not taking drug having adverse eventPatients not taking drug not having adverse event
Febrile neutropenia 1109.96 15.79 880 54501 104665 56132021
Neutropenia 1031.91 15.79 1005 54376 157162 56079524
Thrombocytopenia 753.00 15.79 792 54589 135432 56101254
Disease progression 634.11 15.79 641 54740 104532 56132154
Malignant neoplasm progression 593.39 15.79 527 54854 73060 56163626
Bone marrow failure 497.48 15.79 323 55058 27963 56208723
Mucosal inflammation 496.84 15.79 379 55002 42431 56194255
Haematotoxicity 491.43 15.79 214 55167 8169 56228517
Anaemia 422.35 15.79 858 54523 266653 55970033
Vomiting 418.50 15.79 1253 54128 496975 55739711
Ototoxicity 411.54 15.79 114 55267 1052 56235634
Pancytopenia 360.18 15.79 440 54941 88275 56148411
Myelosuppression 340.85 15.79 213 55168 17242 56219444
Nausea 279.80 15.79 1481 53900 762697 55473989
Leukopenia 272.00 15.79 342 55039 70598 56166088
Arthralgia 269.54 15.79 80 55301 501589 55735097
Acute myeloid leukaemia 267.31 15.79 181 55200 16791 56219895
Dehydration 263.88 15.79 521 54860 158304 56078382
Posterior reversible encephalopathy syndrome 246.10 15.79 168 55213 15792 56220894
Second primary malignancy 240.62 15.79 126 55255 7276 56229410
Hypomagnesaemia 229.36 15.79 193 55188 24822 56211864
Off label use 223.08 15.79 1107 54274 555073 55681613
Joint swelling 218.03 15.79 18 55363 289782 55946904
Neutrophil count decreased 195.38 15.79 243 55138 49579 56187107
Hypokalaemia 188.08 15.79 335 55046 94102 56142584
Renal salt-wasting syndrome 181.80 15.79 46 55335 287 56236399
Pain 178.04 15.79 236 55145 662948 55573738
Deafness 171.62 15.79 137 55244 16357 56220329
Ovarian germ cell teratoma 166.44 15.79 35 55346 78 56236608
Myelodysplastic syndrome 165.88 15.79 134 55247 16272 56220414
Diffuse large B-cell lymphoma recurrent 165.30 15.79 63 55318 1694 56234992
Abdominal discomfort 162.37 15.79 37 55344 277237 55959449
Teratoma 160.85 15.79 37 55344 143 56236543
Arthropathy 160.58 15.79 9 55372 200266 56036420
Neutropenic sepsis 153.47 15.79 124 55257 15061 56221625
Aortic thrombosis 150.52 15.79 51 55330 966 56235720
Metastases to lung 149.74 15.79 110 55271 11608 56225078
Neoplasm progression 146.59 15.79 169 55212 31847 56204839
Peripheral swelling 146.35 15.79 27 55354 234699 56001987
Platelet count decreased 146.09 15.79 323 55058 106060 56130626
Product dose omission issue 145.22 15.79 16 55365 204737 56031949
Nephropathy toxic 144.02 15.79 95 55286 8432 56228254
Drug resistance 143.62 15.79 136 55245 20406 56216280
Metastases to central nervous system 141.87 15.79 108 55273 12028 56224658
Contraindicated product administered 141.60 15.79 11 55370 186275 56050411
Gastrointestinal toxicity 140.38 15.79 83 55298 6073 56230613
Fall 138.31 15.79 91 55290 357419 55879267
Therapeutic product effect decreased 134.64 15.79 8 55373 169444 56067242
Musculoskeletal stiffness 131.56 15.79 5 55376 156002 56080684
Sepsis 130.16 15.79 366 55015 139474 56097212
Diffuse large B-cell lymphoma refractory 126.30 15.79 46 55335 1086 56235600
Swelling 123.49 15.79 41 55340 239730 55996956
Acute kidney injury 119.44 15.79 511 54870 240252 55996434
Pulmonary embolism 118.52 15.79 299 55082 106825 56129861
Hyponatraemia 116.05 15.79 288 55093 101851 56134835
Pyrexia 112.33 15.79 750 54631 418023 55818663
Weight increased 110.29 15.79 44 55337 229659 56007027
Urogenital fistula 109.80 15.79 28 55353 181 56236505
Drug hypersensitivity 107.79 15.79 69 55312 275136 55961550
Hypocalcaemia 107.49 15.79 137 55244 28623 56208063
Neurotoxicity 107.42 15.79 103 55278 15692 56220994
Cardiomyopathy 104.90 15.79 103 55278 16155 56220531
Nasopharyngitis 103.37 15.79 44 55337 220915 56015771
Cardiotoxicity 100.43 15.79 73 55308 7577 56229109
Oesophagitis 100.04 15.79 94 55287 13963 56222723
Pain in extremity 96.87 15.79 90 55291 297341 55939345
Metastases to liver 95.54 15.79 112 55269 21474 56215212
Wound 95.52 15.79 12 55369 138792 56097894
Rash 94.17 15.79 217 55164 492830 55743856
Pruritus 93.80 15.79 104 55277 316519 55920167
Headache 92.24 15.79 265 55116 558779 55677907
Product use in unapproved indication 91.83 15.79 326 55055 140496 56096190
Tumour lysis syndrome 91.48 15.79 70 55311 7853 56228833
Drug ineffective 90.19 15.79 534 54847 918455 55318231
Metastases to lymph nodes 88.84 15.79 67 55314 7356 56229330
Septic shock 88.33 15.79 189 55192 60646 56176040
Hydronephrosis 88.19 15.79 73 55308 9169 56227517
Therapy partial responder 88.18 15.79 68 55313 7717 56228969
Renal failure 87.33 15.79 273 55108 110227 56126459
Disease recurrence 85.00 15.79 111 55270 23749 56212937
Arthritis 84.85 15.79 3 55378 99849 56136837
Neuropathy peripheral 84.83 15.79 258 55123 102635 56134051
Sinusitis 82.29 15.79 46 55335 197535 56039151
White blood cell count decreased 81.55 15.79 291 55090 125699 56110987
Hypophagia 81.38 15.79 120 55261 28756 56207930
Asthma 79.43 15.79 9 55372 112761 56123925
Insomnia 79.42 15.79 45 55336 191815 56044871
Condition aggravated 79.35 15.79 136 55245 344762 55891924
Contusion 77.40 15.79 16 55365 128414 56108272
Pericarditis 75.95 15.79 9 55372 108914 56127772
Injection site pain 73.95 15.79 13 55368 117105 56119581
Tinnitus 73.61 15.79 117 55264 29925 56206761
Drug intolerance 73.02 15.79 92 55289 264726 55971960
Oesophageal fistula 72.83 15.79 19 55362 136 56236550
Hepatic enzyme increased 72.67 15.79 39 55342 171345 56065341
Blister 71.17 15.79 11 55370 108876 56127810
Renal tubular disorder 71.16 15.79 39 55342 2467 56234219
Teratoma benign 70.57 15.79 16 55365 57 56236629
Ascites 69.34 15.79 129 55252 37415 56199271
Febrile bone marrow aplasia 69.23 15.79 55 55326 6517 56230169
Migraine 69.21 15.79 4 55377 86793 56149893
Electrolyte imbalance 67.53 15.79 86 55295 17947 56218739
Palmar-plantar erythrodysaesthesia syndrome 67.39 15.79 93 55288 20972 56215714
Ovarian cancer recurrent 66.85 15.79 29 55352 1095 56235591
Renal impairment 64.29 15.79 200 55181 80513 56156173
Radiation skin injury 63.36 15.79 26 55355 853 56235833
Muscle spasms 63.18 15.79 28 55353 137343 56099343
Metastases to skin 62.66 15.79 30 55351 1428 56235258
Gastrointestinal perforation 62.32 15.79 39 55342 3160 56233526
Decreased appetite 61.20 15.79 397 54984 218834 56017852
Metastases to bone 60.72 15.79 85 55296 19423 56217263
Leukoencephalopathy 60.62 15.79 42 55339 4040 56232646
Discomfort 60.46 15.79 32 55349 141729 56094957
Renal tubular necrosis 59.65 15.79 63 55318 10765 56225921
Diarrhoea 59.21 15.79 918 54463 637589 55599097
Pleural effusion 58.36 15.79 201 55180 85279 56151407
Infusion related reaction 58.18 15.79 72 55309 208859 56027827
Metastases to breast 56.29 15.79 18 55363 282 56236404
Abdominal pain 56.17 15.79 441 54940 258364 55978322
Deafness bilateral 55.83 15.79 27 55354 1314 56235372
Osteoarthritis 55.08 15.79 7 55374 80289 56156397
Polyneuropathy 54.92 15.79 66 55315 12984 56223702
Loss of personal independence in daily activities 53.67 15.79 8 55373 81361 56155325
Alopecia 52.84 15.79 133 55248 293325 55943361
Blood creatinine increased 52.52 15.79 186 55195 80005 56156681
Large intestine perforation 51.13 15.79 50 55331 7801 56228885
Urticaria 50.40 15.79 41 55340 144635 56092051
Deep vein thrombosis 49.09 15.79 177 55204 76800 56159886
Gait disturbance 49 15.79 53 55328 163268 56073418
Inappropriate antidiuretic hormone secretion 49.00 15.79 64 55317 13692 56222994
Myasthenia gravis crisis 48.56 15.79 18 55363 447 56236239
Haemoglobin decreased 48.43 15.79 260 55121 133877 56102809
Overdose 47.98 15.79 22 55359 105808 56130878
Metastases to peritoneum 47.19 15.79 32 55349 2972 56233714
Fatigue 46.76 15.79 524 54857 788028 55448658
Fibromyalgia 46.75 15.79 3 55378 59600 56177086
Feeling abnormal 46.36 15.79 38 55343 133564 56103122
Depression 46.13 15.79 66 55315 180051 56056635
Peripheral artery thrombosis 45.94 15.79 26 55355 1751 56234935
Injection site erythema 45.93 15.79 10 55371 77438 56159248
Encephalopathy 45.90 15.79 105 55276 35220 56201466
Mobility decreased 45.78 15.79 20 55361 98971 56137715
Suicidal ideation 45.01 15.79 3 55378 57739 56178947
Bronchitis 44.12 15.79 28 55353 112283 56124403
Mesenteric abscess 41.43 15.79 11 55370 85 56236601
Plasma cell leukaemia 40.92 15.79 21 55360 1162 56235524
Drug clearance decreased 40.88 15.79 22 55359 1342 56235344
Malignant transformation 40.56 15.79 15 55366 370 56236316
Chemical peritonitis 40.45 15.79 11 55370 94 56236592
Hospitalisation 40.03 15.79 12 55369 74988 56161698
Ileus 39.55 15.79 58 55323 13824 56222862
Cystitis haemorrhagic 39.45 15.79 32 55349 3905 56232781
Injury 39.21 15.79 6 55375 59845 56176841
Bicytopenia 39.05 15.79 25 55356 2108 56234578
Large intestinal ulcer perforation 38.91 15.79 10 55371 67 56236619
Cytopenia 38.88 15.79 48 55333 9707 56226979
Somnolence 38.83 15.79 63 55318 163350 56073336
Asthenia 38.36 15.79 510 54871 342463 55894223
Anastomotic leak 38.19 15.79 15 55366 438 56236248
Lower respiratory tract infection 38.18 15.79 34 55347 114760 56121926
Recall phenomenon 37.91 15.79 16 55365 564 56236122
Gastric perforation 37.88 15.79 22 55359 1556 56235130
Cervix carcinoma recurrent 37.76 15.79 9 55372 42 56236644
Performance status decreased 37.58 15.79 29 55352 3294 56233392
Adverse drug reaction 37.44 15.79 9 55372 65123 56171563
Wernicke's encephalopathy 37.40 15.79 8 55373 20 56236666
Exposure during pregnancy 36.88 15.79 48 55333 136294 56100392
Cervix neoplasm 36.67 15.79 12 55369 203 56236483
Ureteric rupture 36.63 15.79 7 55374 7 56236679
Cataract 36.30 15.79 4 55377 51243 56185443
Nasal abscess 36.22 15.79 11 55370 144 56236542
Balance disorder 36.12 15.79 15 55366 76505 56160181
Dermatitis 35.71 15.79 58 55323 15099 56221587
Embryonal rhabdomyosarcoma 35.70 15.79 7 55374 9 56236677
Nephritis bacterial 35.62 15.79 8 55373 27 56236659
Maternal exposure during pregnancy 35.59 15.79 84 55297 189469 56047217
Bladder perforation 35.41 15.79 11 55370 156 56236530
Dizziness 35.33 15.79 221 55160 375919 55860767
Blood cholesterol increased 34.62 15.79 14 55367 72565 56164121
Metastases to abdominal wall 34.59 15.79 10 55371 109 56236577
Pericardial effusion 34.45 15.79 80 55301 27095 56209591
Cardiac tamponade 34.21 15.79 31 55350 4395 56232291
Radiation injury 34.18 15.79 14 55367 457 56236229
Intentional product misuse 34.11 15.79 5 55376 51499 56185187
Gastrointestinal fungal infection 34.08 15.79 12 55369 256 56236430
Nasal congestion 33.99 15.79 7 55374 56363 56180323
Cerebral venous thrombosis 33.98 15.79 22 55359 1891 56234795
Melanoderma 33.96 15.79 11 55370 180 56236506
Injection site reaction 33.40 15.79 6 55375 53241 56183445
Neutropenic colitis 33.36 15.79 25 55356 2718 56233968
Lung adenocarcinoma 33.33 15.79 31 55350 4543 56232143
Treatment failure 33.20 15.79 74 55307 170318 56066368
Adverse event 33.14 15.79 7 55374 55369 56181317
Unevaluable event 33.08 15.79 4 55377 47683 56189003
Folliculitis 32.80 15.79 7 55374 54972 56181714
Varicella zoster virus infection 32.43 15.79 24 55357 2560 56234126
Chloroma 32.28 15.79 11 55370 212 56236474
Stress 32.22 15.79 9 55372 58901 56177785
Malnutrition 32.19 15.79 53 55328 13955 56222731
Peripheral ischaemia 32.05 15.79 30 55351 4433 56232253
Cerebellar haemangioma 32.02 15.79 9 55372 88 56236598
Osteosarcoma 31.74 15.79 10 55371 149 56236537
Haemophagocytic lymphohistiocytosis 31.73 15.79 43 55338 9529 56227157
Tumour haemorrhage 31.46 15.79 19 55362 1445 56235241
Metastases to adrenals 31.42 15.79 15 55366 709 56235977
Axillary vein thrombosis 31.30 15.79 12 55369 328 56236358
Herpes simplex encephalitis 31.19 15.79 12 55369 331 56236355
Wheezing 30.44 15.79 18 55363 75008 56161678
Venoocclusive liver disease 30.38 15.79 29 55352 4392 56232294
Metastasis 30.28 15.79 30 55351 4754 56231932
Enteritis 30.27 15.79 37 55344 7406 56229280
Respiratory failure 30.14 15.79 178 55203 94884 56141802
Vesical fistula 30.00 15.79 8 55373 63 56236623
Anxiety 29.96 15.79 94 55287 193078 56043608
Cervix carcinoma 29.93 15.79 24 55357 2881 56233805
Abortion spontaneous 29.56 15.79 4 55377 43749 56192937
Haemolytic uraemic syndrome 29.40 15.79 22 55359 2386 56234300
Product use issue 29.22 15.79 90 55291 185951 56050735
Peripheral sensory neuropathy 28.97 15.79 35 55346 6921 56229765
Neoplasm recurrence 28.95 15.79 22 55359 2442 56234244
Diffuse large B-cell lymphoma 28.73 15.79 35 55346 6981 56229705
Ovarian cancer 28.66 15.79 33 55348 6205 56230481
White blood cell count abnormal 28.59 15.79 32 55349 5835 56230851
Osteoporosis 28.38 15.79 8 55373 52044 56184642
Dysphagia 28.31 15.79 157 55224 81790 56154896
Female genital tract fistula 28.12 15.79 28 55353 4464 56232222
Wrong technique in product usage process 28.11 15.79 11 55370 58157 56178529
Sinus polyp 27.95 15.79 11 55370 323 56236363
Vena cava thrombosis 27.74 15.79 20 55361 2049 56234637
Acoustic stimulation tests abnormal 27.61 15.79 8 55373 88 56236598
Disseminated intravascular coagulation 27.61 15.79 57 55324 17828 56218858
Enterocolitis infectious 27.51 15.79 18 55363 1575 56235111
Impaired healing 27.36 15.79 27 55354 86814 56149872
Inappropriate schedule of product administration 27.36 15.79 25 55356 83362 56153324
Gastrooesophageal reflux disease 27.27 15.79 25 55356 83232 56153454
Memory impairment 27.17 15.79 27 55354 86530 56150156
Hypophosphataemia 26.87 15.79 40 55341 9662 56227024
Alveolar soft part sarcoma 26.75 15.79 8 55373 99 56236587
Adrenocortical carcinoma 26.72 15.79 7 55374 51 56236635
Malaise 26.46 15.79 233 55148 367627 55869059
Cervix cancer metastatic 26.37 15.79 7 55374 54 56236632
Suicide attempt 26.24 15.79 12 55369 57824 56178862
Chronic kidney disease 26.20 15.79 96 55285 41960 56194726
Pneumonia salmonella 26.17 15.79 5 55376 5 56236681
Radiation pneumonitis 26.14 15.79 17 55364 1472 56235214
Clostridium bacteraemia 25.92 15.79 9 55372 184 56236502
Intestinal perforation 25.90 15.79 42 55339 10917 56225769
Acquired gene mutation 25.73 15.79 14 55367 873 56235813
Ill-defined disorder 25.68 15.79 18 55363 68525 56168161
Hypoalbuminaemia 25.57 15.79 41 55340 10558 56226128
Bacteraemia 25.53 15.79 51 55330 15580 56221106
Thymus enlargement 25.53 15.79 8 55373 117 56236569
Hypersensitivity 25.44 15.79 148 55233 256260 55980426
Aortic embolus 25.35 15.79 6 55375 27 56236659
Osteosarcoma metastatic 25.35 15.79 6 55375 27 56236659
Neutrophil count abnormal 25.28 15.79 21 55360 2649 56234037
Fistula of small intestine 24.81 15.79 10 55371 313 56236373
Metastases to abdominal cavity 24.74 15.79 11 55370 441 56236245
Amputation stump pain 24.67 15.79 6 55375 31 56236655
Multiple organ dysfunction syndrome 24.54 15.79 110 55271 52660 56184026
Respiratory symptom 24.48 15.79 21 55360 2769 56233917
Influenza like illness 24.23 15.79 15 55366 60973 56175713
Metastases to meninges 23.91 15.79 19 55362 2251 56234435
Stem cell transplant 23.71 15.79 17 55364 1727 56234959
Jaw operation 23.58 15.79 13 55368 832 56235854
Thrombotic microangiopathy 23.52 15.79 37 55344 9374 56227312
Extremity necrosis 23.44 15.79 16 55365 1502 56235184
Arteriospasm coronary 23.32 15.79 23 55358 3624 56233062
Oesophageal stenosis 23.20 15.79 21 55360 2972 56233714
Pneumonitis 23.09 15.79 76 55305 31488 56205198
Acute respiratory distress syndrome 22.96 15.79 60 55321 21866 56214820
Enterococcal sepsis 22.90 15.79 15 55366 1315 56235371
Embolism 22.79 15.79 32 55349 7332 56229354
Urinary tract infection bacterial 22.71 15.79 25 55356 4475 56232211
Anti-Muellerian hormone level decreased 22.68 15.79 7 55374 97 56236589
Radiation oesophagitis 22.50 15.79 9 55372 276 56236410
Malignant peritoneal neoplasm 22.42 15.79 12 55369 724 56235962
Acute myelomonocytic leukaemia 22.32 15.79 8 55373 180 56236506
Gestational trophoblastic tumour 22.31 15.79 6 55375 49 56236637
Burning sensation 22.25 15.79 10 55371 48686 56188000
Incorrect dose administered 22.19 15.79 12 55369 52535 56184151
Blood magnesium decreased 22.17 15.79 41 55340 11833 56224853
Fluid retention 21.90 15.79 13 55368 54065 56182621
Hypoaesthesia 21.82 15.79 69 55312 141422 56095264
Odynophagia 21.65 15.79 30 55351 6788 56229898
Ovarian vein thrombosis 21.50 15.79 6 55375 57 56236629
Femur fracture 21.49 15.79 6 55375 39289 56197397
Vascular compression 21.47 15.79 7 55374 117 56236569
Oroticaciduria 21.47 15.79 4 55377 3 56236683
Influenza 21.44 15.79 38 55343 95223 56141463
Sleep disorder 21.36 15.79 21 55360 67642 56169044
Median nerve injury 21.22 15.79 5 55376 22 56236664
Tachycardia 21.06 15.79 177 55204 105699 56130987
Failure to thrive 21 15.79 29 55352 6541 56230145
Maternal death affecting foetus 20.93 15.79 4 55377 4 56236682
Therapy responder 20.87 15.79 9 55372 335 56236351
Lymphopenia 20.84 15.79 49 55332 16725 56219961
Blood glucose increased 20.78 15.79 26 55355 75125 56161561
Vision blurred 20.62 15.79 31 55350 82912 56153774
Blood pressure fluctuation 20.57 15.79 7 55374 40353 56196333
Pulmonary vascular disorder 20.50 15.79 9 55372 350 56236336
Cytomegalovirus infection 20.41 15.79 53 55328 19243 56217443
Blood sodium decreased 20.28 15.79 58 55323 22276 56214410
Small cell lung cancer 20.18 15.79 15 55366 1611 56235075
Pregnancy 20.13 15.79 4 55377 33029 56203657
Radiation proctitis 20.04 15.79 4 55377 6 56236680
Superior sagittal sinus thrombosis 19.78 15.79 11 55370 716 56235970
Peritonitis 19.77 15.79 47 55334 16155 56220531
VIth nerve paresis 19.72 15.79 6 55375 79 56236607
Renal-limited thrombotic microangiopathy 19.66 15.79 4 55377 7 56236679
Refeeding syndrome 19.65 15.79 5 55376 32 56236654
Metastases to pelvis 19.65 15.79 9 55372 387 56236299
Hiccups 19.59 15.79 16 55365 1972 56234714
Diabetes mellitus 19.56 15.79 14 55367 52721 56183965
Neck pain 19.55 15.79 19 55362 61536 56175150
Gastrointestinal necrosis 19.53 15.79 18 55363 2608 56234078
Radiation mucositis 19.52 15.79 5 55376 33 56236653
Respiratory distress 19.49 15.79 72 55309 31595 56205091
Drug clearance increased 19.26 15.79 6 55375 86 56236600
Myalgia 19.24 15.79 66 55315 131959 56104727
Granulocytopenia 19.24 15.79 25 55356 5319 56231367
Leukaemic lymphoma 19.19 15.79 6 55375 87 56236599
Lymphangioleiomyomatosis 19.19 15.79 7 55374 166 56236520
Purulent pericarditis 19.02 15.79 5 55376 37 56236649
Product quality issue 19.01 15.79 4 55377 31732 56204954
Medulloblastoma recurrent 19.00 15.79 6 55375 90 56236596
Salivary gland cancer 18.80 15.79 7 55374 176 56236510
Low cardiac output syndrome 18.77 15.79 8 55373 289 56236397
Aortitis 18.72 15.79 12 55369 1014 56235672
Marchiafava-Bignami disease 18.70 15.79 4 55377 10 56236676
Hepatic lesion 18.69 15.79 22 55359 4233 56232453
Cannabinoid hyperemesis syndrome 18.68 15.79 5 55376 40 56236646
Pain in jaw 18.65 15.79 8 55373 40028 56196658
Cerebral salt-wasting syndrome 18.57 15.79 5 55376 41 56236645
Dry eye 18.54 15.79 6 55375 35710 56200976
Gastroenteritis radiation 18.42 15.79 9 55372 448 56236238
Mucosal erosion 18.33 15.79 13 55368 1298 56235388
Sweat gland tumour 18.31 15.79 6 55375 102 56236584
Hypoacusis 18.30 15.79 55 55326 21713 56214973
Gastric disorder 18.29 15.79 5 55376 33205 56203481
Blood pressure increased 18.29 15.79 77 55304 145099 56091587
Pelvic fluid collection 18.29 15.79 11 55370 830 56235856
Muscular weakness 18.25 15.79 48 55333 104404 56132282
Sinus tachycardia 18.21 15.79 56 55325 22388 56214298
Hypoglycaemia 17.99 15.79 17 55364 55798 56180888
Proctitis 17.98 15.79 17 55364 2543 56234143
Cerebral ischaemia 17.96 15.79 26 55355 6124 56230562
Uterine atrophy 17.87 15.79 5 55376 48 56236638
Road traffic accident 17.84 15.79 3 55378 27924 56208762
Urinary tract toxicity 17.78 15.79 3 55378 0 56236686
Emphysematous cholecystitis 17.78 15.79 3 55378 0 56236686
Hypoglossal nerve paresis 17.74 15.79 6 55375 113 56236573
Multiple sclerosis 17.73 15.79 3 55378 27799 56208887
Metastases to pleura 17.71 15.79 13 55368 1369 56235317
Tumour thrombosis 17.70 15.79 4 55377 14 56236672
Transdifferentiation of neoplasm 17.70 15.79 4 55377 14 56236672
Osteoradionecrosis 17.59 15.79 6 55375 116 56236570
Ovarian disorder 17.54 15.79 10 55371 683 56236003
Bursitis 17.53 15.79 3 55378 27579 56209107
Aorto-oesophageal fistula 17.48 15.79 4 55377 15 56236671
Central obesity 17.46 15.79 12 55369 1139 56235547
Roseolovirus test positive 17.42 15.79 5 55376 53 56236633
Tearfulness 17.42 15.79 20 55361 3748 56232938
Neuroblastoma 17.40 15.79 6 55375 120 56236566
Neurosensory hypoacusis 17.34 15.79 7 55374 220 56236466
Necrosis 17.34 15.79 23 55358 4993 56231693
Cardiopulmonary failure 17.24 15.79 19 55362 3406 56233280
Staphylococcal infection 17.18 15.79 78 55303 37540 56199146
Urogenital disorder 17.09 15.79 5 55376 57 56236629
Liver abscess 17.08 15.79 17 55364 2709 56233977
Ovarian failure 16.96 15.79 12 55369 1193 56235493
Deafness neurosensory 16.95 15.79 22 55359 4676 56232010
Abdominal compartment syndrome 16.84 15.79 9 55372 541 56236145
Necrotising colitis 16.81 15.79 9 55372 543 56236143
Chronic obstructive pulmonary disease 16.80 15.79 19 55362 57396 56179290
Melanosis 16.72 15.79 4 55377 19 56236667
Blood culture positive 16.70 15.79 21 55360 4325 56232361
Confusional state 16.69 15.79 128 55253 208027 56028659
Renal tubular dysfunction 16.63 15.79 8 55373 385 56236301
Joint stiffness 16.62 15.79 7 55374 35418 56201268
Tumour invasion 16.58 15.79 6 55375 139 56236547
Plasma cell myeloma 16.53 15.79 90 55291 46556 56190130
Blood phosphorus decreased 16.47 15.79 20 55361 3977 56232709
Lip swelling 16.39 15.79 3 55378 26269 56210417
Clostridium difficile colitis 16.38 15.79 48 55333 18690 56217996
Myasthenic syndrome 16.37 15.79 7 55374 255 56236431
Eye pain 16.34 15.79 5 55376 30842 56205844
Fanconi syndrome 16.29 15.79 12 55369 1271 56235415
Stent malfunction 16.29 15.79 5 55376 68 56236618
Pseudomonal sepsis 16.29 15.79 15 55366 2171 56234515
Tracheal stenosis 16.23 15.79 6 55375 148 56236538
Systemic infection 16.22 15.79 18 55363 3251 56233435
Sedation 16.17 15.79 7 55374 34847 56201839
Throat irritation 16.09 15.79 6 55375 32677 56204009
Neuromyopathy 16.07 15.79 9 55372 594 56236092
Surgery 15.93 15.79 6 55375 32480 56204206
Metastases to retroperitoneum 15.86 15.79 6 55375 158 56236528
Hypoxia 15.86 15.79 99 55282 53798 56182888
Skin toxicity 15.85 15.79 20 55361 4133 56232553
Therapy interrupted 15.83 15.79 3 55378 25622 56211064

FDA Adverse Event Reporting System (Male)

MedDRA adverse event termLikelihood ratioLikelihood ratio thresholdPatients taking drug having adverse eventPatients taking drug not having adverse eventPatients not taking drug having adverse eventPatients not taking drug not having adverse event
Febrile neutropenia 1406.68 13.19 1629 78290 120220 31497205
Neutropenia 926.67 13.19 1429 78490 138935 31478490
Mucosal inflammation 761.65 13.19 657 79262 33770 31583655
Thrombocytopenia 552.10 13.19 1152 78767 141595 31475830
Malignant neoplasm progression 486.07 13.19 780 79139 78218 31539207
Pancytopenia 414.89 13.19 769 79150 86547 31530878
Disease progression 394.32 13.19 768 79151 89696 31527729
Dehydration 359.89 13.19 872 79047 118239 31499186
Bone marrow failure 352.87 13.19 393 79526 27615 31589810
Leukopenia 341.81 13.19 561 79358 57267 31560158
Myelosuppression 340.31 13.19 290 79629 14630 31602795
Vomiting 295.01 13.19 1230 78689 222743 31394682
Haematotoxicity 280.73 13.19 192 79727 6945 31610480
Stomatitis 275.14 13.19 413 79506 39025 31578400
Neutropenic sepsis 260.84 13.19 230 79689 12149 31605276
Dysphagia 247.76 13.19 487 79432 57189 31560236
Nausea 241.36 13.19 1460 78459 306487 31310938
Neoplasm progression 239.18 13.19 275 79644 19997 31597428
Acute myeloid leukaemia 228.25 13.19 258 79661 18414 31599011
Anaemia 222.03 13.19 1094 78825 212428 31404997
Second primary malignancy 207.65 13.19 159 79760 6873 31610552
Drug abuse 205.66 13.19 3 79916 87755 31529670
Neutrophil count decreased 204.37 13.19 396 79523 45998 31571427
Product dose omission issue 202.84 13.19 17 79902 105569 31511856
Arthralgia 180.49 13.19 78 79841 151346 31466079
Pulmonary embolism 177.74 13.19 530 79389 81116 31536309
Off label use 172.11 13.19 1475 78444 345799 31271626
Therapy partial responder 171.36 13.19 138 79781 6424 31611001
Aortic thrombosis 170.30 13.19 65 79854 645 31616780
Nephropathy toxic 168.79 13.19 174 79745 11179 31606246
Fall 167.97 13.19 134 79785 185955 31431470
Renal salt-wasting syndrome 154.41 13.19 48 79871 237 31617188
Myelodysplastic syndrome 147.77 13.19 211 79708 19040 31598385
Drug interaction 137.07 13.19 196 79723 208347 31409078
Pyrexia 136.60 13.19 1264 78655 302576 31314849
Cardiotoxicity 131.86 13.19 106 79813 4921 31612504
Decreased appetite 131.40 13.19 745 79174 152472 31464953
Ototoxicity 127.63 13.19 70 79849 1688 31615737
Tumour lysis syndrome 123.07 13.19 172 79747 15213 31602212
Overdose 115.38 13.19 35 79884 84629 31532796
Hyponatraemia 114.96 13.19 428 79491 73371 31544054
Diffuse large B-cell lymphoma refractory 112.90 13.19 55 79864 1028 31616397
Headache 109.72 13.19 184 79735 183468 31433957
Septic shock 109.21 13.19 391 79528 65767 31551658
White blood cell count decreased 107.53 13.19 471 79448 86927 31530498
Diffuse large B-cell lymphoma recurrent 107.52 13.19 76 79843 2899 31614526
Hypomagnesaemia 105.88 13.19 180 79739 18878 31598547
Anastomotic leak 104.56 13.19 44 79875 574 31616851
Weight increased 101.51 13.19 41 79878 82906 31534519
Oesophagitis 101.08 13.19 140 79779 12276 31605149
Acute kidney injury 98.37 13.19 1107 78812 278607 31338818
Rhabdomyolysis 94.73 13.19 22 79897 63559 31553866
Arterial thrombosis 94.59 13.19 54 79865 1410 31616015
Depression 94.30 13.19 56 79863 90759 31526666
Febrile bone marrow aplasia 93.45 13.19 107 79812 7739 31609686
Cardiac failure congestive 92.74 13.19 42 79877 79345 31538080
Psoriasis 91.11 13.19 7 79912 46712 31570713
Rheumatoid arthritis 90.92 13.19 8 79911 47801 31569624
Hypophagia 90.77 13.19 183 79736 21859 31595566
Aorto-oesophageal fistula 90.42 13.19 22 79897 31 31617394
Radiation skin injury 89.96 13.19 41 79878 655 31616770
Metastases to lung 88.94 13.19 108 79811 8314 31609111
Deafness 88.20 13.19 120 79799 10345 31607080
Tinnitus 86.84 13.19 151 79768 16124 31601301
Muscle spasms 86.51 13.19 32 79887 68286 31549139
Odynophagia 84.28 13.19 82 79837 4911 31612514
Hospitalisation 83.18 13.19 13 79906 49794 31567631
Peripheral swelling 82.29 13.19 34 79885 67831 31549594
Sepsis 81.52 13.19 658 79261 151271 31466154
Anxiety 81.43 13.19 66 79853 90967 31526458
Inappropriate antidiuretic hormone secretion 80.39 13.19 120 79799 11267 31606158
Osteoradionecrosis 80.11 13.19 22 79897 63 31617362
Gastric perforation 80.06 13.19 58 79861 2301 31615124
Platelet count decreased 79.88 13.19 514 79405 109921 31507504
Metastases to central nervous system 79.15 13.19 97 79822 7539 31609886
Intentional product misuse 79.04 13.19 4 79915 37947 31579478
Suicide attempt 77.34 13.19 4 79915 37244 31580181
Peripheral ischaemia 76.55 13.19 80 79839 5220 31612205
Vena cava thrombosis 75.90 13.19 42 79877 1031 31616394
Musculoskeletal stiffness 75.72 13.19 8 79911 41317 31576108
Insomnia 75.03 13.19 77 79842 94759 31522666
Joint swelling 74.77 13.19 21 79898 53410 31564015
Asthma 73.75 13.19 10 79909 42601 31574824
Product use in unapproved indication 73.20 13.19 464 79455 98707 31518718
Nasopharyngitis 73.01 13.19 34 79885 63211 31554214
Suicidal ideation 72.29 13.19 5 79914 36401 31581024
Peripheral artery thrombosis 71.93 13.19 53 79866 2159 31615266
Myalgia 71.64 13.19 54 79865 77204 31540221
Pneumonitis 71.40 13.19 204 79715 30448 31586977
Osteosarcoma 71.18 13.19 27 79892 263 31617162
Blood pressure increased 69.65 13.19 59 79860 79574 31537851
Oesophageal fistula 68.95 13.19 25 79894 212 31617213
Pain in extremity 67.86 13.19 118 79801 116085 31501340
Neutropenic colitis 66.88 13.19 55 79864 2637 31614788
Hypokalaemia 66.80 13.19 290 79629 53284 31564141
Inappropriate schedule of product administration 65.70 13.19 23 79896 50800 31566625
Aplasia 65.34 13.19 66 79853 4137 31613288
Gastrointestinal toxicity 64.03 13.19 50 79869 2224 31615201
Splenic infarction 62.42 13.19 46 79873 1874 31615551
Deafness neurosensory 62.32 13.19 53 79866 2663 31614762
Bacterial translocation 61.27 13.19 25 79894 300 31617125
Condition aggravated 60.81 13.19 211 79708 163798 31453627
Renal failure 60.69 13.19 524 79395 122806 31494619
General physical health deterioration 60.62 13.19 491 79428 112944 31504481
Dermatitis 60.16 13.19 90 79829 8466 31608959
Prostate cancer 60.16 13.19 11 79908 37590 31579835
Death 59.97 13.19 601 79318 359968 31257457
Injection site pain 57.91 13.19 9 79910 34625 31582800
Metastases to liver 57.64 13.19 110 79809 12617 31604808
Cardiac disorder 57.55 13.19 14 79905 39200 31578225
Dizziness 57.15 13.19 283 79636 198864 31418561
Radiation pneumonitis 56.71 13.19 48 79871 2396 31615029
Portal venous gas 55.83 13.19 24 79895 331 31617094
Aggression 55.34 13.19 13 79906 37278 31580147
Wheezing 54.50 13.19 12 79907 35974 31581451
Hypertension 54.36 13.19 155 79764 127945 31489480
Oesophagobronchial fistula 53.25 13.19 19 79900 153 31617272
Heart rate decreased 53.01 13.19 5 79914 28261 31589164
Pruritus 52.71 13.19 152 79767 125015 31492410
COVID-19 52.52 13.19 37 79882 54784 31562641
Hiccups 51.95 13.19 88 79831 9199 31608226
Hypocalcaemia 51.88 13.19 147 79772 21831 31595594
Malignant transformation 51.75 13.19 30 79889 807 31616618
Tumour necrosis 51.62 13.19 34 79885 1153 31616272
Thrombotic microangiopathy 51.51 13.19 88 79831 9263 31608162
Renal impairment 51.23 13.19 383 79536 85966 31531459
Radiation oesophagitis 51.10 13.19 24 79895 412 31617013
Atypical haemolytic uraemic syndrome 51.06 13.19 20 79899 214 31617211
Tremor 50.89 13.19 71 79848 76349 31541076
Colitis 50.60 13.19 194 79725 33693 31583732
Hepatitis B 49.79 13.19 67 79852 5714 31611711
Gait disturbance 49.63 13.19 74 79845 77421 31540004
Blood creatine phosphokinase increased 49.32 13.19 22 79897 41952 31575473
Vision blurred 49.20 13.19 22 79897 41893 31575532
Salivary gland cancer 49.02 13.19 21 79898 287 31617138
Hallucination 49.02 13.19 28 79891 46382 31571043
Electrolyte imbalance 48.98 13.19 100 79819 12048 31605377
Oesophageal stenosis 48.87 13.19 37 79882 1571 31615854
Pulmonary vascular disorder 48.58 13.19 26 79893 596 31616829
Acute respiratory distress syndrome 48.35 13.19 154 79765 24386 31593039
Neuropathy peripheral 48.00 13.19 341 79578 75308 31542117
Influenza 47.89 13.19 26 79893 44299 31573126
Leukoencephalopathy 47.80 13.19 54 79865 3848 31613577
Feeling abnormal 47.70 13.19 44 79875 56958 31560467
Disease recurrence 47.20 13.19 128 79791 18533 31598892
Foetal exposure during pregnancy 47.13 13.19 22 79897 40854 31576571
Respiratory failure 46.25 13.19 424 79495 101025 31516400
Mobility decreased 46.24 13.19 7 79912 27462 31589963
B-cell lymphoma recurrent 46.13 13.19 26 79893 662 31616763
Ameloblastoma 45.96 13.19 15 79904 89 31617336
Bacteraemia 45.65 13.19 122 79797 17512 31599913
Coronary artery disease 45.62 13.19 30 79889 46057 31571368
Wrong technique in product usage process 45.00 13.19 14 79905 33329 31584096
Deep vein thrombosis 44.66 13.19 284 79635 60452 31556973
Renal tubular disorder 44.06 13.19 55 79864 4355 31613070
Somnolence 43.91 13.19 118 79801 99327 31518098
Metastases to lymph nodes 43.88 13.19 54 79865 4214 31613211
Arthritis 43.83 13.19 8 79911 27377 31590048
Azoospermia 43.52 13.19 21 79898 384 31617041
Carotid artery thrombosis 43.25 13.19 20 79899 331 31617094
Renal infarct 42.98 13.19 31 79888 1221 31616204
Urticaria 42.91 13.19 49 79870 57468 31559957
Blood pressure fluctuation 42.69 13.19 4 79915 22732 31594693
Intestinal ischaemia 42.41 13.19 69 79850 6976 31610449
Cytomegalovirus oesophagitis 42.38 13.19 22 79897 473 31616952
Drug hypersensitivity 42.10 13.19 74 79845 72525 31544900
Enteritis 42.02 13.19 69 79850 7030 31610395
Neoplasm recurrence 41.98 13.19 38 79881 2076 31615349
Memory impairment 41.73 13.19 22 79897 38108 31579317
Therapeutic product effect decreased 41.40 13.19 14 79905 31608 31585817
Angioedema 40.48 13.19 17 79902 33601 31583824
Incorrect dose administered 40.06 13.19 20 79899 35732 31581693
Lymphopenia 40.02 13.19 102 79817 14227 31603198
Pulmonary arteriopathy 40.00 13.19 13 79906 76 31617349
Pain 39.07 13.19 293 79626 186466 31430959
Adverse drug reaction 38.98 13.19 8 79911 25193 31592232
Anastomotic complication 38.96 13.19 19 79900 356 31617069
Embolism 38.30 13.19 67 79852 7186 31610239
Pneumatosis intestinalis 38.23 13.19 47 79872 3664 31613761
Bronchial fistula 38.01 13.19 15 79904 164 31617261
Interstitial lung disease 37.90 13.19 275 79644 61128 31556297
Tumour perforation 37.56 13.19 17 79902 267 31617158
Balance disorder 37.53 13.19 24 79895 37398 31580027
Influenza like illness 37.48 13.19 9 79910 25428 31591997
Diarrhoea 37.45 13.19 1157 78762 351252 31266173
Hypoglycaemia 37.36 13.19 44 79875 50902 31566523
Alopecia 37.30 13.19 126 79793 20569 31596856
Blood stem cell transplant failure 37.00 13.19 19 79900 399 31617026
Tumour haemorrhage 36.76 13.19 39 79880 2589 31614836
Chemotherapy 36.72 13.19 21 79898 550 31616875
Radiation mucositis 35.97 13.19 15 79904 191 31617234
Tracheo-oesophageal fistula 35.96 13.19 19 79900 424 31617001
Cataract 35.92 13.19 8 79911 23799 31593626
Electrocardiogram QT prolonged 35.91 13.19 26 79893 37961 31579464
Metastasis 35.89 13.19 45 79874 3579 31613846
Large intestine perforation 35.82 13.19 67 79852 7569 31609856
Blood sodium decreased 35.72 13.19 102 79817 15213 31602212
Product prescribing error 35.47 13.19 4 79915 19638 31597787
Hypoacusis 35.08 13.19 100 79819 14899 31602526
Neurosensory hypoacusis 34.90 13.19 7 79912 0 31617425
Unevaluable event 34.41 13.19 17 79902 30558 31586867
Teratoma 34.39 13.19 9 79910 20 31617405
International normalised ratio increased 34.30 13.19 38 79881 45185 31572240
Abdominal discomfort 34.23 13.19 48 79871 51519 31565906
Osteoarthritis 34.14 13.19 4 79915 19063 31598362
Rash 33.71 13.19 335 79584 201151 31416274
Testicular germ cell cancer metastatic 33.46 13.19 11 79908 67 31617358
Depressed mood 33.25 13.19 3 79916 17572 31599853
Myocardial infarction 33.19 13.19 160 79759 113294 31504131
Empyema 32.95 13.19 39 79880 2922 31614503
Acquired gene mutation 32.85 13.19 27 79892 1293 31616132
Oedema peripheral 32.66 13.19 154 79765 109685 31507740
Nasal congestion 32.51 13.19 6 79913 20375 31597050
Chloroma 32.51 13.19 19 79900 519 31616906
Palmar-plantar erythrodysaesthesia syndrome 32.19 13.19 99 79820 15384 31602041
Blood glucose increased 32.13 13.19 66 79853 61017 31556408
Chronic obstructive pulmonary disease 32.06 13.19 40 79879 45126 31572299
Chest discomfort 31.74 13.19 47 79872 49322 31568103
Recall phenomenon 31.68 13.19 19 79900 545 31616880
Back pain 31.60 13.19 155 79764 109258 31508167
Dyskinesia 31.60 13.19 7 79912 20903 31596522
Progressive multifocal leukoencephalopathy 31.57 13.19 71 79848 9142 31608283
Sedation 31.54 13.19 5 79914 18960 31598465
Pulmonary toxicity 31.47 13.19 52 79867 5325 31612100
Serotonin syndrome 31.11 13.19 5 79914 18768 31598657
Bicytopenia 31.01 13.19 32 79887 2057 31615368
Confusional state 30.89 13.19 203 79716 133131 31484294
Contusion 30.70 13.19 23 79896 33005 31584420
Mantle cell lymphoma recurrent 30.24 13.19 18 79901 509 31616916
Bradycardia 30.03 13.19 83 79836 69244 31548181
Erectile dysfunction 29.97 13.19 6 79913 19229 31598196
Gout 29.76 13.19 5 79914 18169 31599256
Osteosarcoma recurrent 29.63 13.19 8 79911 21 31617404
Blood HIV RNA increased 29.61 13.19 24 79895 1127 31616298
Nephrolithiasis 29.58 13.19 16 79903 27323 31590102
Papillary thyroid cancer 29.58 13.19 19 79900 617 31616808
Toxicity to various agents 29.42 13.19 304 79615 181183 31436242
Hyperammonaemic encephalopathy 29.32 13.19 32 79887 2194 31615231
Pharyngeal inflammation 29.17 13.19 15 79904 316 31617109
Injury 28.98 13.19 7 79912 19702 31597723
Primitive neuroectodermal tumour 28.76 13.19 10 79909 74 31617351
Malaise 28.66 13.19 279 79640 168232 31449193
Blood creatinine increased 28.64 13.19 347 79572 88731 31528694
Arterial occlusive disease 28.57 13.19 43 79876 4066 31613359
Liver function test abnormal 28.48 13.19 20 79899 29672 31587753
Radiation injury 28.46 13.19 17 79902 484 31616941
Pancreatitis 28.31 13.19 29 79890 35742 31581683
Disseminated intravascular coagulation 27.77 13.19 114 79805 20423 31597002
Gait inability 27.76 13.19 7 79912 19137 31598288
Drug resistance 27.73 13.19 125 79794 23328 31594097
Sleep disorder 27.67 13.19 16 79903 26332 31591093
Hepatic candidiasis 27.49 13.19 9 79910 54 31617371
Peritonitis 27.34 13.19 93 79826 15234 31602191
Metastatic gastric cancer 27.25 13.19 12 79907 176 31617249
Abnormal behaviour 27.19 13.19 13 79906 23815 31593610
Drug ineffective 27.18 13.19 775 79144 394798 31222627
Plasma cell leukaemia 26.97 13.19 21 79898 930 31616495
Cystitis haemorrhagic 26.82 13.19 48 79871 5241 31612184
Sinusitis 26.57 13.19 32 79887 36664 31580761
Extravasation 26.43 13.19 27 79892 1715 31615710
Cytopenia 26.33 13.19 74 79845 10936 31606489
Hypophosphataemia 26.31 13.19 63 79856 8451 31608974
Fluid retention 26.13 13.19 15 79904 24787 31592638
Flagellate dermatitis 26.07 13.19 9 79910 65 31617360
Accidental overdose 26.06 13.19 7 79912 18343 31599082
Enterocolitis 25.99 13.19 57 79862 7217 31610208
Angina pectoris 25.85 13.19 22 79897 29619 31587806
Non-small cell lung cancer 25.77 13.19 41 79878 4068 31613357
Emotional distress 25.73 13.19 3 79916 14353 31603072
Localised infection 25.44 13.19 4 79915 15261 31602164
Product administration error 25.40 13.19 4 79915 15243 31602182
Irritability 25.35 13.19 13 79906 22876 31594549
Blindness cortical 25.32 13.19 14 79905 343 31617082
Cerebral ischaemia 25.17 13.19 50 79869 5905 31611520
Oral candidiasis 25.08 13.19 73 79846 11004 31606421
Dermatitis acneiform 25.08 13.19 49 79870 5718 31611707
Muscular weakness 25.02 13.19 83 79836 65365 31552060
Diabetes mellitus 25.00 13.19 43 79876 42513 31574912
Therapy cessation 24.97 13.19 4 79915 15051 31602374
Agitation 24.86 13.19 63 79856 54106 31563319
Blood cholesterol increased 24.84 13.19 6 79913 16887 31600538
Blood pressure systolic increased 24.83 13.19 9 79910 19461 31597964
Hepatitis B reactivation 24.72 13.19 37 79882 3481 31613944
Adenocarcinoma gastric 24.55 13.19 22 79897 1186 31616239
Cerebral venous sinus thrombosis 24.53 13.19 15 79904 446 31616979
Pleural mesothelioma malignant 24.45 13.19 9 79910 80 31617345
Refeeding syndrome 24.32 13.19 7 79912 25 31617400
Neurotoxicity 24.30 13.19 93 79826 16133 31601292
Superior mesenteric artery syndrome 24.25 13.19 9 79910 82 31617343
EGFR gene mutation 24.07 13.19 10 79909 126 31617299
Granulocyte count decreased 24.06 13.19 17 79902 648 31616777
Testicular malignant teratoma 24.05 13.19 6 79913 10 31617415
Lactic acidosis 24.04 13.19 27 79892 31910 31585515
Gastrooesophageal reflux disease 24.03 13.19 30 79889 33841 31583584
Lymphadenopathy mediastinal 24.03 13.19 29 79890 2217 31615208
Cerebral infarction 23.96 13.19 129 79790 25848 31591577
Cerebral venous thrombosis 23.87 13.19 17 79902 656 31616769
Pneumothorax 23.77 13.19 95 79824 16815 31600610
Road traffic accident 23.74 13.19 6 79913 16375 31601050
Loss of personal independence in daily activities 23.46 13.19 22 79897 28266 31589159
Small cell lung cancer 23.14 13.19 26 79893 1841 31615584
Refractory cancer 23.13 13.19 10 79909 140 31617285
Sleep apnoea syndrome 23.10 13.19 9 79910 18616 31598809
Gene mutation 23.05 13.19 21 79898 1157 31616268
Blood lactate dehydrogenase increased 23 13.19 107 79812 20232 31597193
Labelled drug-drug interaction medication error 22.98 13.19 3 79916 13160 31604265
Retinal toxicity 22.84 13.19 14 79905 418 31617007
Haematochezia 22.77 13.19 42 79877 40422 31577003
Arteriospasm coronary 22.63 13.19 32 79887 2859 31614566
Diaphragm muscle weakness 22.63 13.19 10 79909 148 31617277
Diffuse large B-cell lymphoma 22.58 13.19 60 79859 8581 31608844
Myoclonus 22.57 13.19 4 79915 13986 31603439
Procedural vomiting 22.51 13.19 10 79909 150 31617275
Wound 22.44 13.19 3 79916 12925 31604500
Paraneoplastic syndrome 22.43 13.19 15 79904 522 31616903
Necrosis 22.30 13.19 44 79875 5172 31612253
Metastases to peritoneum 22.10 13.19 24 79895 1636 31615789
Oesophageal perforation 22.06 13.19 19 79900 971 31616454
Granulocyte-colony stimulating factor level increased 22.00 13.19 5 79914 4 31617421
Lung adenocarcinoma 22.00 13.19 40 79879 4422 31613003
Procedural nausea 21.94 13.19 8 79911 69 31617356
Embolism arterial 21.88 13.19 15 79904 544 31616881
Morphoea 21.87 13.19 10 79909 161 31617264
Hypochloraemia 21.69 13.19 15 79904 552 31616873
Cholelithiasis 21.66 13.19 11 79908 19468 31597957
Gastrointestinal ischaemia 21.60 13.19 10 79909 166 31617259
Necrosis ischaemic 21.51 13.19 11 79908 229 31617196
Hot flush 21.50 13.19 7 79912 16189 31601236
Polyneuropathy 21.48 13.19 77 79842 12945 31604480
Psychotic disorder 21.40 13.19 15 79904 22278 31595147
Blood glucose decreased 21.40 13.19 3 79916 12468 31604957
Deafness bilateral 21.36 13.19 19 79900 1014 31616411
Pleural effusion 21.17 13.19 285 79634 74635 31542790
Coronary artery thrombosis 21.14 13.19 26 79893 2027 31615398
Tumour thrombosis 21.08 13.19 8 79911 78 31617347
Herpes zoster 21.01 13.19 30 79889 31963 31585462
Soft tissue disorder 20.96 13.19 16 79903 688 31616737
Upper respiratory tract infection 20.94 13.19 26 79893 29396 31588029
Hyperhidrosis 20.90 13.19 93 79826 67300 31550125
Adenoviral hepatitis 20.79 13.19 14 79905 493 31616932
Performance status decreased 20.71 13.19 36 79883 3842 31613583
Mitral valve incompetence 20.60 13.19 5 79914 14028 31603397
Immune-mediated dermatitis 20.57 13.19 10 79909 186 31617239
Vascular injury 20.37 13.19 11 79908 257 31617168
Metastases to skin 20.27 13.19 13 79906 421 31617004
Neutrophil count abnormal 20.13 13.19 23 79896 1659 31615766
Arteritis 20.01 13.19 12 79907 344 31617081
Swelling 19.95 13.19 40 79879 37318 31580107
Speech disorder 19.86 13.19 19 79900 24182 31593243
Product quality issue 19.63 13.19 8 79911 16103 31601322
Transient ischaemic attack 19.61 13.19 19 79900 24037 31593388
Adrenocortical carcinoma 19.58 13.19 6 79913 28 31617397
Failure to thrive 19.52 13.19 54 79865 7908 31609517
Underdose 19.50 13.19 4 79915 12603 31604822
Extremity necrosis 19.46 13.19 23 79896 1720 31615705
Campylobacter test positive 19.41 13.19 6 79913 29 31617396
Carotid artery dissection 19.40 13.19 9 79910 150 31617275
Bronchitis 19.38 13.19 43 79876 38674 31578751
Palpitations 19.37 13.19 36 79883 34547 31582878
Loss of consciousness 19.33 13.19 115 79804 77240 31540185
B-cell lymphoma refractory 19.30 13.19 9 79910 152 31617273
Accidental exposure to product 19.18 13.19 3 79916 11492 31605933
Disturbance in attention 19.17 13.19 17 79902 22433 31594992
Transitional cell carcinoma recurrent 19.14 13.19 5 79914 11 31617414
Cell-mediated immune deficiency 19.08 13.19 6 79913 31 31617394
Peritoneal lesion 19.03 13.19 8 79911 104 31617321
Visual impairment 18.93 13.19 31 79888 31248 31586177
Full blood count decreased 18.91 13.19 9 79910 16531 31600894
Laryngeal pain 18.90 13.19 28 79891 2610 31614815
Hypoaesthesia 18.80 13.19 75 79844 55947 31561478
Peripheral sensory neuropathy 18.73 13.19 46 79873 6269 31611156
Iliac artery occlusion 18.73 13.19 9 79910 163 31617262
Hyperlipidaemia 18.72 13.19 5 79914 13155 31604270
Haematoma 18.62 13.19 20 79899 24119 31593306
Medulloblastoma recurrent 18.56 13.19 7 79912 67 31617358
Osteosarcoma metastatic 18.56 13.19 5 79914 13 31617412
Metastases to chest wall 18.53 13.19 9 79910 167 31617258
Gastrointestinal perforation 18.47 13.19 33 79886 3599 31613826
Intestinal infarction 18.43 13.19 13 79906 494 31616931
Seminoma 18.42 13.19 10 79909 236 31617189
Transformation to acute myeloid leukaemia 18.26 13.19 15 79904 718 31616707
Delusion 18.16 13.19 4 79915 11993 31605432
Movement disorder 18.11 13.19 3 79916 11016 31606409
Visceral venous thrombosis 18.03 13.19 5 79914 15 31617410
Hypoalbuminaemia 18.01 13.19 65 79854 10963 31606462
Injection site erythema 17.92 13.19 7 79912 14455 31602970
Hepatic enzyme increased 17.88 13.19 40 79879 35868 31581557
Burning sensation 17.83 13.19 10 79909 16737 31600688
Urinary tract infection 17.80 13.19 117 79802 76752 31540673
Metastases to bone 17.77 13.19 64 79855 10784 31606641
Metastases to meninges 17.68 13.19 19 79900 1280 31616145
Rectal haemorrhage 17.62 13.19 41 79878 36263 31581162
Withdrawal syndrome 17.55 13.19 4 79915 11713 31605712
Drug clearance decreased 17.50 13.19 21 79898 1596 31615829
Pneumonia adenoviral 17.49 13.19 11 79908 344 31617081
Dermatitis diaper 17.31 13.19 10 79909 267 31617158
Swelling face 17.31 13.19 17 79902 21373 31596052
Candida infection 17.27 13.19 84 79835 16174 31601251
Drug intolerance 17.24 13.19 70 79849 51963 31565462
Traumatic lung injury 17.24 13.19 18 79901 1173 31616252
Meningitis tuberculous 17.22 13.19 14 79905 660 31616765
Trigeminal nerve paresis 17.18 13.19 4 79915 4 31617421
Spinal column injury 17.17 13.19 13 79906 552 31616873
Oesophageal pain 17.16 13.19 15 79904 782 31616643
BK virus infection 17.16 13.19 39 79880 5056 31612369
Venous thrombosis 17.10 13.19 30 79889 3225 31614200
Colitis ulcerative 17.10 13.19 13 79906 18516 31598909
Gingivitis ulcerative 17.07 13.19 6 79913 46 31617379
Fanconi syndrome 17.04 13.19 21 79898 1641 31615784
Gastrointestinal anastomotic leak 17.02 13.19 11 79908 361 31617064
Dementia 17.02 13.19 5 79914 12355 31605070
Infected neoplasm 17.01 13.19 7 79912 86 31617339
Chemotherapeutic drug level increased 16.99 13.19 9 79910 202 31617223
Type 2 diabetes mellitus 16.97 13.19 8 79911 14776 31602649
Blood creatinine 16.96 13.19 6 79913 47 31617378
Human chorionic gonadotropin increased 16.93 13.19 5 79914 20 31617405
Eye pain 16.90 13.19 5 79914 12299 31605126
Hepatic steatosis 16.85 13.19 10 79909 16229 31601196
Laryngeal inflammation 16.74 13.19 5 79914 21 31617404
Immune-mediated hepatic disorder 16.65 13.19 13 79906 578 31616847
Chondrosarcoma 16.64 13.19 6 79913 50 31617375
Blister 16.53 13.19 17 79902 20919 31596506
Haemoptysis 16.44 13.19 138 79781 32051 31585374
Respiratory depression 16.43 13.19 8 79911 14502 31602923
Subcutaneous emphysema 16.42 13.19 17 79902 1097 31616328
Lymphangiosis carcinomatosa 16.27 13.19 15 79904 839 31616586
Hypersomnia 16.25 13.19 4 79915 11115 31606310
Dysstasia 16.25 13.19 4 79915 11114 31606311
Frequent bowel movements 16.18 13.19 3 79916 10156 31607269
Eosinophilia 16.08 13.19 21 79898 23232 31594193
Treatment noncompliance 15.97 13.19 25 79894 25659 31591766
Wound evisceration 15.82 13.19 7 79912 104 31617321
Blood triglycerides increased 15.77 13.19 7 79912 13390 31604035
Ureteric dilatation 15.75 13.19 8 79911 164 31617261
Urine sodium increased 15.68 13.19 6 79913 60 31617365
Rib fracture 15.60 13.19 7 79912 13309 31604116
Ganglioneuroma 15.57 13.19 4 79915 8 31617417
Extragonadal primary germ cell tumour mixed 15.57 13.19 4 79915 8 31617417
Chromaturia 15.57 13.19 7 79912 13291 31604134
Lymphadenopathy 15.54 13.19 116 79803 26005 31591420
Myelitis transverse 15.47 13.19 16 79903 1031 31616394
White blood cell disorder 15.44 13.19 19 79900 1482 31615943
Testicular cancer metastatic 15.42 13.19 6 79913 63 31617362
Mucosal toxicity 15.39 13.19 9 79910 246 31617179
Agranulocytosis 15.38 13.19 99 79820 21148 31596277
Choriocarcinoma 15.27 13.19 5 79914 30 31617395
Nasal sinus cancer 15.27 13.19 5 79914 30 31617395
Osteomyelitis 15.22 13.19 9 79910 14634 31602791
Laboratory test abnormal 15.17 13.19 15 79904 18799 31598626
Plasmacytoma 15.06 13.19 29 79890 3348 31614077
Paranoia 15.04 13.19 4 79915 10551 31606874
Head injury 14.97 13.19 12 79907 16646 31600779
Pharyngeal stenosis 14.96 13.19 3 79916 0 31617425
Carotid artery perforation 14.96 13.19 3 79916 0 31617425
Salivary gland cancer recurrent 14.96 13.19 3 79916 0 31617425
Evans syndrome 14.80 13.19 9 79910 265 31617160
Gastrointestinal haemorrhage 14.72 13.19 135 79784 82414 31535011
Seizure 14.59 13.19 171 79748 99597 31517828
Bone sarcoma 14.56 13.19 6 79913 74 31617351
Aortitis 14.48 13.19 10 79909 367 31617058
Metapneumovirus bronchiolitis 14.43 13.19 4 79915 12 31617413
Oesophageal squamous cell carcinoma 14.32 13.19 10 79909 374 31617051
Subdural haematoma 14.32 13.19 16 79903 18955 31598470
Thrombocytosis 14.25 13.19 30 79889 3693 31613732
Illness 14.23 13.19 3 79916 9274 31608151
Thrombotic thrombocytopenic purpura 14.22 13.19 28 79891 3285 31614140
Subclavian vein thrombosis 14.19 13.19 14 79905 853 31616572
Hip fracture 14.14 13.19 5 79914 10981 31606444
Malocclusion 14.14 13.19 6 79913 80 31617345
Hyperglycaemic hyperosmolar nonketotic syndrome 14.13 13.19 16 79903 1143 31616282
Renal tubular necrosis 14.09 13.19 74 79845 14685 31602740
Basal cell carcinoma 14.09 13.19 15 79904 18164 31599261
JC virus infection 14.05 13.19 21 79898 1973 31615452
Apparent mineralocorticoid excess 14.04 13.19 5 79914 40 31617385
Eczema 13.99 13.19 11 79908 15406 31602019
Viral load increased 13.94 13.19 22 79897 2167 31615258
Blood magnesium decreased 13.94 13.19 39 79880 5747 31611678
Limb injury 13.94 13.19 4 79915 10037 31607388
Haemoperitoneum 13.92 13.19 19 79900 1642 31615783
Tooth disorder 13.91 13.19 4 79915 10025 31607400
Dropped head syndrome 13.90 13.19 7 79912 141 31617284
Premature baby 13.89 13.19 15 79904 18051 31599374
Cellulitis 13.86 13.19 68 79851 47950 31569475
Platelet transfusion 13.82 13.19 17 79902 1326 31616099
Retinopathy 13.77 13.19 20 79899 1831 31615594
Cardiogenic shock 13.76 13.19 22 79897 22386 31595039
Cerebrovascular accident 13.74 13.19 131 79788 79353 31538072
Chronic hepatitis B 13.73 13.19 5 79914 43 31617382
Enterococcal bacteraemia 13.68 13.19 19 79900 1669 31615756
Dyspnoea exertional 13.67 13.19 51 79868 38786 31578639
Therapeutic embolisation 13.64 13.19 9 79910 306 31617119
Penile vein thrombosis 13.55 13.19 4 79915 16 31617409
Torulopsis infection 13.55 13.19 4 79915 16 31617409
Fistula of small intestine 13.51 13.19 10 79909 410 31617015
Hypovolaemia 13.38 13.19 49 79870 8323 31609102
Sarcoma 13.34 13.19 10 79909 418 31617007
Focal nodular hyperplasia 13.26 13.19 7 79912 156 31617269
Hemianopia 13.25 13.19 12 79907 656 31616769
Heart rate irregular 13.21 13.19 10 79909 14279 31603146
Alpha 1 foetoprotein increased 13.20 13.19 12 79907 659 31616766

FDA Adverse Event Reporting System (Geriatric)

MedDRA adverse event termLikelihood ratioLikelihood ratio thresholdPatients taking drug having adverse eventPatients taking drug not having adverse eventPatients not taking drug having adverse eventPatients not taking drug not having adverse event
Febrile neutropenia 2265.46 12.70 2198 115427 202120 70608699
Neutropenia 1670.18 12.70 2090 115535 255066 70555753
Thrombocytopenia 1206.35 12.70 1719 115906 237391 70573428
Mucosal inflammation 1086.50 12.70 900 116725 66950 70743869
Malignant neoplasm progression 1028.65 12.70 1134 116491 120605 70690214
Pancytopenia 818.29 12.70 1125 116500 149982 70660837
Disease progression 804.50 12.70 1137 116488 155535 70655284
Bone marrow failure 773.68 12.70 645 116980 48365 70762454
Haematotoxicity 680.71 12.70 368 117257 13306 70797513
Myelosuppression 636.20 12.70 471 117154 29674 70781145
Anaemia 560.83 12.70 1702 115923 401721 70409098
Leukopenia 537.12 12.70 767 116858 105793 70705026
Acute myeloid leukaemia 502.30 12.70 414 117211 30526 70780293
Dehydration 477.29 12.70 1115 116510 225027 70585792
Arthralgia 476.50 12.70 124 117501 503266 70307553
Vomiting 457.43 12.70 2068 115557 591043 70219776
Rheumatoid arthritis 440.02 12.70 9 117616 291796 70519023
Second primary malignancy 413.23 12.70 262 117363 12789 70798030
Neutropenic sepsis 351.23 12.70 307 117318 24523 70786296
Nausea 347.97 12.70 2506 115119 849582 69961237
Neutrophil count decreased 337.87 12.70 543 117082 83013 70727806
Off label use 331.69 12.70 2234 115391 740826 70069993
Aortic thrombosis 323.78 12.70 115 117510 1448 70809371
Ototoxicity 318.24 12.70 135 117490 2806 70808013
Neoplasm progression 315.25 12.70 382 117243 44846 70765973
Renal salt-wasting syndrome 314.75 12.70 91 117534 552 70810267
Fall 304.19 12.70 180 117445 443916 70366903
Joint swelling 293.66 12.70 37 117588 253174 70557645
Nephropathy toxic 272.12 12.70 234 117391 18280 70792539
Hypomagnesaemia 269.07 12.70 335 117290 40429 70770390
Myelodysplastic syndrome 267.65 12.70 287 117338 29498 70781321
Product dose omission issue 259.01 12.70 29 117596 217439 70593380
Pulmonary embolism 255.69 12.70 699 116926 155168 70655651
Acute kidney injury 242.42 12.70 1478 116147 473146 70337673
Pain 231.70 12.70 432 117193 628384 70182435
Therapy partial responder 230.22 12.70 180 117445 12294 70798525
Pyrexia 227.39 12.70 1751 115874 605201 70205618
Peripheral swelling 225.83 12.70 57 117568 236506 70574313
Drug abuse 224.00 12.70 4 117621 147252 70663567
Tumour lysis syndrome 217.35 12.70 220 117405 21140 70789679
Cardiotoxicity 209.21 12.70 162 117463 10908 70799911
Arthropathy 206.95 12.70 10 117615 150047 70660772
Headache 206.52 12.70 407 117218 579998 70230821
Diffuse large B-cell lymphoma recurrent 205.54 12.70 105 117520 3371 70807448
Sepsis 205.13 12.70 876 116749 243669 70567150
Platelet count decreased 204.16 12.70 705 116920 177517 70633302
Metastases to lung 203.88 12.70 189 117436 16295 70794524
Musculoskeletal stiffness 203.29 12.70 10 117615 147750 70663069
Dysphagia 203.19 12.70 524 117101 112310 70698509
Weight increased 203.12 12.70 74 117551 242257 70568562
Deafness 202.25 12.70 202 117423 19101 70791718
Metastases to central nervous system 192.99 12.70 176 117449 14858 70795961
Decreased appetite 189.50 12.70 1001 116624 303779 70507040
Nasopharyngitis 184.28 12.70 69 117556 222137 70588682
Septic shock 179.58 12.70 499 117126 111759 70699060
Posterior reversible encephalopathy syndrome 174.73 12.70 209 117416 24193 70786626
Abdominal discomfort 172.48 12.70 70 117555 214588 70596231
Drug hypersensitivity 170.31 12.70 113 117512 262346 70548473
Anastomotic leak 169.69 12.70 64 117561 965 70809854
Pain in extremity 167.77 12.70 178 117447 327904 70482915
Hyponatraemia 167.65 12.70 615 117010 159472 70651347
Therapeutic product effect decreased 165.47 12.70 21 117604 142997 70667822
Hypokalaemia 165.29 12.70 536 117089 130652 70680167
Teratoma 163.37 12.70 42 117583 150 70810669
White blood cell count decreased 161.15 12.70 633 116992 169508 70641311
Tinnitus 158.46 12.70 244 117381 35932 70774887
Stomatitis 153.79 12.70 516 117109 127995 70682824
Product use in unapproved indication 151.17 12.70 713 116912 206765 70604054
Overdose 150.60 12.70 47 117578 169698 70641121
Systemic lupus erythematosus 150.13 12.70 4 117621 101898 70708921
Oesophagitis 149.20 12.70 186 117439 22466 70788353
Asthma 144.03 12.70 16 117609 120777 70690042
Renal failure 143.80 12.70 658 116967 188412 70622407
Swelling 142.71 12.70 67 117558 188472 70622347
Injection site pain 141.71 12.70 15 117610 117604 70693215
Drug resistance 140.54 12.70 238 117387 37952 70772867
Ovarian germ cell teratoma 139.63 12.70 33 117592 74 70810745
Radiation skin injury 139.00 12.70 60 117565 1303 70809516
Insomnia 138.29 12.70 96 117529 217710 70593109
Pruritus 137.29 12.70 226 117399 345334 70465485
Condition aggravated 135.17 12.70 320 117305 427315 70383504
Diffuse large B-cell lymphoma refractory 131.88 12.70 57 117568 1242 70809577
Neuropathy peripheral 131.55 12.70 486 117139 126410 70684409
Psoriasis 131.21 12.70 8 117617 98425 70712394
Oesophageal fistula 130.93 12.70 41 117584 338 70810481
Inappropriate antidiuretic hormone secretion 129.71 12.70 176 117449 23100 70787719
Metastases to liver 128.31 12.70 185 117440 25693 70785126
Muscle spasms 127.40 12.70 48 117577 153998 70656821
Gastrointestinal toxicity 125.99 12.70 96 117529 6309 70804510
Contraindicated product administered 125.40 12.70 34 117591 134578 70676241
Hypocalcaemia 125.13 12.70 248 117377 44611 70766208
Arthritis 124.71 12.70 10 117615 97970 70712849
Pemphigus 123.30 12.70 3 117622 83033 70727786
Febrile bone marrow aplasia 122.89 12.70 124 117501 11867 70798952
Osteosarcoma 121.80 12.70 40 117585 390 70810429
Hypophagia 121.03 12.70 234 117391 41336 70769483
Wound 120.47 12.70 12 117613 98720 70712099
Contusion 119.91 12.70 32 117593 128004 70682815
Renal impairment 118.50 12.70 513 117112 143424 70667395
Peripheral artery thrombosis 118.33 12.70 71 117554 3136 70807683
Metastases to lymph nodes 116.33 12.70 107 117518 9131 70801688
Disease recurrence 112.33 12.70 214 117411 37389 70773430
Depression 112.01 12.70 99 117526 198875 70611944
Sinusitis 110.84 12.70 72 117553 169123 70641696
Aorto-oesophageal fistula 110.73 12.70 26 117599 56 70810763
Intentional product misuse 107.52 12.70 6 117619 79589 70731230
Gastric perforation 107.02 12.70 71 117554 3744 70807075
Deep vein thrombosis 105.77 12.70 414 117211 110628 70700191
Palmar-plantar erythrodysaesthesia syndrome 105.38 12.70 184 117441 30063 70780756
Leukoencephalopathy 104.76 12.70 91 117534 7203 70803616
Renal tubular disorder 103.82 12.70 84 117541 6026 70804793
Neurotoxicity 103.35 12.70 181 117444 29645 70781174
Pneumonitis 98.66 12.70 254 117371 54343 70756476
Blister 98.24 12.70 23 117602 100503 70710316
Peripheral ischaemia 97.97 12.70 95 117530 8663 70802156
Venoocclusive liver disease 97.86 12.70 104 117521 10574 70800245
Mobility decreased 97.86 12.70 25 117600 102974 70707845
Anxiety 96.20 12.70 135 117490 220195 70590624
Osteoarthritis 95.96 12.70 7 117618 74140 70736679
Rash 94.85 12.70 480 117145 510082 70300737
Odynophagia 94.84 12.70 100 117525 10075 70800744
Hepatic enzyme increased 93.41 12.70 74 117551 156916 70653903
Dizziness 92.21 12.70 426 117199 463715 70347104
Suicidal ideation 91.73 12.70 6 117619 69590 70741229
Arterial thrombosis 91.43 12.70 55 117570 2441 70808378
Urticaria 90.71 12.70 82 117543 162967 70647852
Migraine 90.20 12.70 8 117617 72230 70738589
Hypoacusis 89.99 12.70 162 117463 27107 70783712
Hiccups 89.83 12.70 92 117533 8960 70801859
Gait disturbance 89.50 12.70 105 117520 185001 70625818
Electrolyte imbalance 89.19 12.70 160 117465 26701 70784118
Malignant transformation 88.99 12.70 42 117583 1131 70809688
Dermatitis 87.89 12.70 133 117492 19284 70791535
Drug intolerance 87.33 12.70 150 117475 225537 70585282
Suicide attempt 86.52 12.70 14 117611 79496 70731323
Radiation pneumonitis 85.35 12.70 61 117564 3632 70807187
Discomfort 85.26 12.70 34 117591 105402 70705417
Hospitalisation 84.52 12.70 17 117608 82551 70728268
Drug interaction 84.36 12.70 336 117289 381105 70429714
Blood pressure increased 83.79 12.70 114 117511 188403 70622416
Wheezing 83.63 12.70 26 117599 94144 70716675
Osteoradionecrosis 83.03 12.70 22 117603 91 70810728
Urogenital fistula 82.14 12.70 23 117602 122 70810697
Feeling abnormal 81.06 12.70 70 117555 142249 70668570
Stress 81.01 12.70 9 117616 67957 70742862
Bacteraemia 80.49 12.70 161 117464 29148 70781671
Teratoma benign 80.20 12.70 20 117605 61 70810758
Bronchitis 77.99 12.70 49 117576 117194 70693625
Recall phenomenon 77.53 12.70 37 117588 1022 70809797
Nasal congestion 77.51 12.70 9 117616 65663 70745156
Injury 76.86 12.70 9 117616 65236 70745583
Myalgia 76.16 12.70 100 117525 167792 70643027
Enteritis 76.05 12.70 100 117525 12731 70798088
Acute respiratory distress syndrome 75.64 12.70 193 117432 41061 70769758
Blood creatinine increased 75.60 12.70 450 117175 142551 70668268
Injection site erythema 74.67 12.70 15 117610 72909 70737910
Balance disorder 74.63 12.70 28 117597 90100 70720719
Inappropriate schedule of product administration 74.27 12.70 43 117582 107512 70703307
Thrombotic microangiopathy 73.44 12.70 117 117508 17731 70793088
Infusion related reaction 72.18 12.70 136 117489 197398 70613421
Bicytopenia 71.90 12.70 57 117568 3971 70806848
Colitis 71.69 12.70 251 117374 63563 70747256
Diarrhoea 71.39 12.70 1750 115875 781591 70029228
Somnolence 70.69 12.70 158 117467 215448 70595371
Deafness bilateral 70.58 12.70 43 117582 1953 70808866
Large intestine perforation 69.34 12.70 97 117528 13098 70797721
Loss of personal independence in daily activities 69.27 12.70 27 117598 84883 70725936
Pulmonary vascular disorder 68.83 12.70 33 117592 921 70809898
Radiation oesophagitis 68.70 12.70 29 117596 595 70810224
Drug ineffective 68.27 12.70 1123 116502 938629 69872190
Rhabdomyolysis 67.97 12.70 37 117588 95723 70715096
Respiratory failure 67.94 12.70 496 117129 168239 70642580
Aplasia 67.12 12.70 71 117554 7180 70803639
Fibromyalgia 66.59 12.70 3 117622 47871 70762948
Wrong technique in product usage process 66.56 12.70 16 117609 68682 70742137
Chloroma 66.02 12.70 30 117595 739 70810080
Influenza 65.87 12.70 55 117570 113645 70697174
Hepatitis B 65.62 12.70 74 117551 8040 70802779
Cardiomyopathy 65.50 12.70 139 117486 26234 70784585
Plasma cell leukaemia 65.37 12.70 40 117585 1831 70808988
Cardiac failure congestive 65.29 12.70 77 117548 135380 70675439
Pleural effusion 65.10 12.70 410 117215 132454 70678365
Blood pressure fluctuation 65.09 12.70 10 117615 59002 70751817
Deafness neurosensory 65.08 12.70 67 117558 6565 70804254
Neutropenic colitis 63.94 12.70 59 117566 5055 70805764
Influenza like illness 63.72 12.70 15 117610 65316 70745503
Osteosarcoma metastatic 62.71 12.70 16 117609 55 70810764
Bacterial translocation 62.67 12.70 26 117599 510 70810309
Metastasis 62.24 12.70 63 117562 6051 70804768
Cystitis haemorrhagic 62.17 12.70 74 117551 8519 70802300
Radiation injury 62.13 12.70 29 117596 761 70810058
Renal tubular necrosis 62.09 12.70 126 117499 23045 70787774
Bronchial fistula 61.84 12.70 20 117605 185 70810634
Cytomegalovirus oesophagitis 61.83 12.70 28 117597 684 70810135
Oesophageal stenosis 61.67 12.70 52 117573 3952 70806867
Portal venous gas 60.85 12.70 23 117602 349 70810470
Exposure during pregnancy 60.66 12.70 35 117590 87682 70723137
Atypical haemolytic uraemic syndrome 60.50 12.70 29 117596 809 70810010
Salivary gland cancer 60.05 12.70 24 117601 426 70810393
Injection site swelling 59.07 12.70 3 117622 43154 70767665
Oesophagobronchial fistula 59.07 12.70 20 117605 216 70810603
Hypophosphataemia 59.07 12.70 101 117524 16225 70794594
Heart rate decreased 59.00 12.70 15 117610 62000 70748819
Blood cholesterol increased 58.88 12.70 17 117608 64587 70746232
Acquired gene mutation 58.74 12.70 39 117586 2059 70808760
Metastases to skin 58.53 12.70 35 117590 1536 70809283
Maternal exposure during pregnancy 58.39 12.70 63 117562 115282 70695537
Metastases to bone 57.98 12.70 120 117505 22256 70788563
Osteoporosis 56.98 12.70 7 117618 48900 70761919
Polyneuropathy 56.85 12.70 116 117509 21299 70789520
Disseminated intravascular coagulation 56.30 12.70 152 117473 33446 70777373
Embolism 56.01 12.70 87 117538 12901 70797918
Cataract 55.83 12.70 12 117613 55633 70755186
Metastases to breast 55.72 12.70 20 117605 260 70810559
Pulmonary arteriopathy 55.63 12.70 16 117609 95 70810724
Vena cava thrombosis 55.52 12.70 41 117584 2569 70808250
Type 2 diabetes mellitus 54.71 12.70 5 117620 44075 70766744
Drug clearance decreased 54.56 12.70 43 117582 2970 70807849
Splenic infarction 54.51 12.70 45 117580 3321 70807498
Electrocardiogram QT prolonged 54.04 12.70 36 117589 83481 70727338
Malaise 53.46 12.70 460 117165 432472 70378347
Memory impairment 53.43 12.70 45 117580 92596 70718223
Hypoglycaemia 53.01 12.70 47 117578 94317 70716502
Tumour haemorrhage 52.57 12.70 46 117579 3676 70807143
Vision blurred 52.53 12.70 48 117577 94936 70715883
Interstitial lung disease 52.49 12.70 325 117300 104360 70706459
Tumour necrosis 52.28 12.70 34 117591 1733 70809086
Cytopenia 52.24 12.70 99 117526 17224 70793595
Ameloblastoma 52.16 12.70 15 117610 89 70810730
Renal infarct 52.06 12.70 39 117586 2498 70808321
Lung adenocarcinoma 52.00 12.70 64 117561 7626 70803193
Serotonin syndrome 51.67 12.70 5 117620 42109 70768710
Empyema 50.85 12.70 46 117579 3841 70806978
Adverse drug reaction 50.56 12.70 13 117612 53331 70757488
Fatigue 50.04 12.70 1016 116609 823303 69987516
Small cell lung cancer 49.96 12.70 40 117585 2826 70807993
Anastomotic complication 49.78 12.70 21 117604 430 70810389
Gastrointestinal perforation 49.72 12.70 54 117571 5627 70805192
Peritonitis 49.64 12.70 124 117501 26035 70784784
Sedation 49.14 12.70 9 117616 46722 70764097
Red blood cell sedimentation rate increased 49.00 12.70 4 117621 38638 70772181
Gastrooesophageal reflux disease 48.95 12.70 47 117578 90792 70720027
Cerebral infarction 48.15 12.70 169 117456 42840 70767979
Lymphopenia 48.10 12.70 126 117499 27233 70783586
Cerebral venous thrombosis 47.94 12.70 37 117588 2478 70808341
General physical health deterioration 47.89 12.70 600 117025 235431 70575388
Pericarditis 47.81 12.70 42 117583 84663 70726156
Fluid retention 47.19 12.70 23 117602 63362 70747457
Performance status decreased 46.87 12.70 52 117573 5549 70805270
Mantle cell lymphoma recurrent 46.45 12.70 21 117604 511 70810308
Neoplasm recurrence 46.45 12.70 44 117581 3897 70806922
Tremor 46.27 12.70 120 117505 155504 70655315
COVID-19 45.92 12.70 65 117560 105692 70705127
Arteriospasm coronary 45.44 12.70 53 117572 5971 70804848
Adrenocortical carcinoma 45.37 12.70 13 117612 76 70810743
Sleep disorder 45.37 12.70 30 117595 69842 70740977
Blood sodium decreased 44.86 12.70 133 117492 30865 70779954
Back pain 44.69 12.70 265 117360 270887 70539932
Hypoaesthesia 44.60 12.70 120 117505 153619 70657200
B-cell lymphoma recurrent 44.56 12.70 24 117601 860 70809959
Blood creatine phosphokinase increased 44.46 12.70 23 117602 61240 70749579
Oedema peripheral 44.21 12.70 211 117414 227880 70582939
Duodenal ulcer perforation 43.81 12.70 15 117610 51097 70759722
Aggression 43.68 12.70 13 117612 48433 70762386
Tumour perforation 43.62 12.70 18 117607 348 70810471
Pulmonary toxicity 43.35 12.70 70 117555 10728 70800091
Blood stem cell transplant failure 43.20 12.70 20 117605 515 70810304
Incorrect dose administered 42.84 12.70 29 117596 66690 70744129
Burning sensation 42.81 12.70 17 117608 52853 70757966
Drug withdrawal syndrome 42.58 12.70 3 117622 32712 70778107
Necrosis 42.03 12.70 61 117564 8520 70802299
Dermatitis acneiform 41.52 12.70 62 117563 8883 70801936
Pneumatosis intestinalis 41.44 12.70 50 117575 5837 70804982
Extremity necrosis 41.13 12.70 36 117589 2878 70807941
Cardiac disorder 40.66 12.70 24 117601 59391 70751428
Coronary artery disease 40.64 12.70 27 117598 62709 70748110
Hallucination 40.45 12.70 40 117585 76220 70734599
Intestinal ischaemia 40.22 12.70 72 117553 11992 70798827
Radiation mucositis 40.21 12.70 15 117610 219 70810600
Nervousness 40.08 12.70 3 117622 31117 70779702
Metastases to peritoneum 40.06 12.70 40 117585 3779 70807040
Palpitations 39.78 12.70 77 117548 110676 70700143
Pneumothorax 39.43 12.70 113 117512 25733 70785086
Blood pressure systolic increased 39.37 12.70 23 117602 57236 70753583
Refeeding syndrome 39.03 12.70 11 117614 60 70810759
Heart rate increased 38.82 12.70 73 117552 106075 70704744
Injection site reaction 38.80 12.70 17 117608 49835 70760984
Hypoalbuminaemia 38.79 12.70 93 117532 19029 70791790
Chronic obstructive pulmonary disease 38.63 12.70 43 117582 77598 70733221
Lactic acidosis 38.21 12.70 31 117594 64993 70745826
Testicular germ cell cancer metastatic 38.14 12.70 11 117614 66 70810753
Road traffic accident 37.97 12.70 6 117619 34676 70776143
Confusional state 37.88 12.70 296 117329 284102 70526717
Product prescribing error 37.87 12.70 9 117616 38943 70771876
Angioedema 37.62 12.70 33 117592 66577 70744242
Hydronephrosis 37.46 12.70 80 117545 15162 70795657
Product use issue 36.92 12.70 163 117462 179774 70631045
Blood lactate dehydrogenase increased 36.74 12.70 135 117490 34992 70775827
Osteosarcoma recurrent 36.71 12.70 10 117615 47 70810772
Lower respiratory tract infection 36.66 12.70 82 117543 111831 70698988
Diffuse large B-cell lymphoma 36.43 12.70 73 117552 13229 70797590
Plasmacytoma 36.29 12.70 39 117586 4015 70806804
Gastrointestinal anastomotic leak 36.18 12.70 17 117608 453 70810366
Gastrointestinal fungal infection 36.06 12.70 16 117609 372 70810447
Cerebral ischaemia 35.82 12.70 63 117562 10349 70800470
Localised infection 35.71 12.70 6 117619 33152 70777667
Unevaluable event 35.67 12.70 21 117604 52042 70758777
Hypersensitivity 35.06 12.70 230 117395 229582 70581237
Peripheral sensory neuropathy 35.03 12.70 68 117557 12042 70798777
Myasthenia gravis crisis 33.95 12.70 21 117604 980 70809839
Gait inability 33.80 12.70 18 117607 47157 70763662
Large intestinal ulcer perforation 33.74 12.70 10 117615 67 70810752
Muscular weakness 33.68 12.70 117 117508 138219 70672600
Neurosensory hypoacusis 33.59 12.70 13 117612 211 70810608
Fanconi syndrome 33.34 12.70 31 117594 2682 70808137
Ureteric rupture 32.99 12.70 7 117618 7 70810812
Coronary artery thrombosis 32.95 12.70 32 117593 2923 70807896
Blindness cortical 32.93 12.70 20 117605 903 70809916
Eye pain 32.92 12.70 8 117617 34094 70776725
Melanoderma 32.92 12.70 15 117610 372 70810447
Abortion spontaneous 32.87 12.70 3 117622 26476 70784343
Throat irritation 32.70 12.70 9 117616 35295 70775524
Toxicity to various agents 32.64 12.70 442 117183 381730 70429089
Joint stiffness 32.52 12.70 9 117616 35167 70775652
Refractory cancer 32.51 12.70 13 117612 231 70810588
Intestinal perforation 32.51 12.70 78 117547 15966 70794853
Tumour thrombosis 32.39 12.70 11 117614 120 70810699
Musculoskeletal pain 32.26 12.70 63 117562 90264 70720555
Wernicke's encephalopathy 32.18 12.70 8 117617 24 70810795
Acoustic stimulation tests abnormal 32.18 12.70 8 117617 24 70810795
Impaired healing 32.00 12.70 46 117579 74328 70736491
Cervix neoplasm 31.99 12.70 12 117613 178 70810641
Gastric disorder 31.81 12.70 8 117617 33314 70777505
Blood glucose increased 31.69 12.70 78 117547 102904 70707915
Primitive neuroectodermal tumour 31.50 12.70 9 117616 52 70810767
Mesenteric abscess 31.44 12.70 11 117614 132 70810687
Irritability 31.43 12.70 12 117613 38213 70772606
Injection site haemorrhage 31.40 12.70 3 117622 25524 70785295
Metastases to meninges 31.35 12.70 32 117593 3104 70807715
Malnutrition 31.16 12.70 89 117536 20228 70790591
Multiple sclerosis 31.03 12.70 3 117622 25282 70785537
Extravasation 30.97 12.70 33 117592 3364 70807455
Non-small cell lung cancer 30.91 12.70 45 117580 6302 70804517
Obesity 30.78 12.70 4 117621 26767 70784052
Accidental exposure to product 30.37 12.70 5 117620 28046 70782773
Nasal abscess 30.37 12.70 11 117614 147 70810672
Product administration error 30.37 12.70 6 117619 29517 70781302
Ascites 30.34 12.70 204 117421 67343 70743476
Swelling face 30.32 12.70 36 117589 63128 70747691
Seminoma 30.23 12.70 12 117613 209 70810610
Underdose 30.17 12.70 6 117619 29377 70781442
Myoclonus 30.15 12.70 4 117621 26351 70784468
Chemical peritonitis 30.13 12.70 13 117612 282 70810537
Candida infection 29.98 12.70 125 117500 34348 70776471
Visceral venous thrombosis 29.83 12.70 7 117618 15 70810804
Cholelithiasis 29.83 12.70 21 117604 47319 70763500
Labelled drug-drug interaction medication error 29.25 12.70 3 117622 24124 70786695
Limb injury 29.24 12.70 4 117621 25748 70785071
Lip swelling 29.17 12.70 10 117615 34044 70776775
Nephritis bacterial 29.13 12.70 8 117617 39 70810780
Tracheal stenosis 29.07 12.70 13 117612 308 70810511
Blood HIV RNA increased 29 12.70 23 117602 1603 70809216
EGFR gene mutation 29.00 12.70 14 117611 397 70810422
Dyskinesia 28.95 12.70 16 117609 41058 70769761
Superior mesenteric artery syndrome 28.86 12.70 11 117614 171 70810648
Hepatic steatosis 28.84 12.70 10 117615 33803 70777016
Pregnancy 28.72 12.70 3 117622 23778 70787041
Basal cell carcinoma 28.69 12.70 10 117615 33688 70777131
Femur fracture 28.63 12.70 12 117613 36120 70774699
Limb discomfort 28.61 12.70 7 117618 29698 70781121
Emotional distress 28.44 12.70 13 117612 37175 70773644
Progressive multifocal leukoencephalopathy 28.34 12.70 83 117542 19131 70791688
Oesophageal perforation 28.33 12.70 21 117604 1323 70809496
Flagellate dermatitis 28.26 12.70 12 117613 250 70810569
International normalised ratio increased 28.23 12.70 57 117568 80669 70730150
Hepatic candidiasis 28.04 12.70 9 117616 81 70810738
Lymphadenopathy mediastinal 27.90 12.70 34 117591 4011 70806808
Blood magnesium decreased 27.79 12.70 70 117555 14771 70796048
Agitation 27.74 12.70 72 117553 93303 70717516
Adenocarcinoma gastric 27.68 12.70 23 117602 1713 70809106
Hepatitis B reactivation 27.59 12.70 39 117586 5316 70805503
Neutrophil count abnormal 27.58 12.70 30 117595 3131 70807688
Sciatica 27.55 12.70 4 117621 24623 70786196
Metastases to adrenals 27.53 12.70 20 117605 1222 70809597
Cerebellar haemangioma 27.38 12.70 9 117616 88 70810731
Sleep apnoea syndrome 27.35 12.70 10 117615 32703 70778116
Haematoma 27.32 12.70 24 117601 48394 70762425
Herpes simplex encephalitis 27.12 12.70 16 117609 685 70810134
Blood pressure diastolic decreased 27.03 12.70 5 117620 25775 70785044
Therapy cessation 26.98 12.70 11 117614 33665 70777154
Prescribed overdose 26.98 12.70 6 117619 27175 70783644
Poisoning 26.94 12.70 3 117622 22619 70788200
Urinary tract infection 26.92 12.70 273 117352 248496 70562323
Upper respiratory tract infection 26.85 12.70 57 117568 79217 70731602
Blood glucose decreased 26.85 12.70 4 117621 24155 70786664
Failure to thrive 26.80 12.70 57 117568 10772 70800047
Agranulocytosis 26.77 12.70 135 117490 40163 70770656
Dry eye 26.77 12.70 10 117615 32272 70778547
Ear infection 26.67 12.70 7 117618 28329 70782490
Necrotising colitis 26.66 12.70 18 117607 977 70809842
Device issue 26.65 12.70 4 117621 24021 70786798
Metastatic gastric cancer 26.63 12.70 13 117612 378 70810441
Myocardial infarction 26.56 12.70 171 117454 171474 70639345
Testicular malignant teratoma 26.55 12.70 6 117619 10 70810809
Cholangitis 26.54 12.70 59 117566 11490 70799329
Cerebral venous sinus thrombosis 26.50 12.70 24 117601 2007 70808812
Hyperhidrosis 26.50 12.70 120 117505 131466 70679353
Papillary thyroid cancer 26.42 12.70 26 117599 2414 70808405
Right ventricular failure 26.41 12.70 3 117622 22271 70788548
Choriocarcinoma 26.26 12.70 10 117615 155 70810664
Erythropenia 26.01 12.70 13 117612 398 70810421
Plasma cell myeloma 25.98 12.70 209 117416 72992 70737827
Enterocolitis 25.92 12.70 63 117562 13003 70797816
Alpha 1 foetoprotein increased 25.82 12.70 16 117609 749 70810070
Traumatic lung injury 25.77 12.70 25 117600 2280 70808539
BK virus infection 25.77 12.70 47 117578 7942 70802877
Pancreatitis 25.75 12.70 40 117585 62628 70748191
Diabetes mellitus 25.73 12.70 50 117575 71774 70739045
Metastatic neoplasm 25.67 12.70 35 117590 4613 70806206
Pain in jaw 25.50 12.70 20 117605 42649 70768170
Haemoptysis 25.32 12.70 159 117466 51293 70759526
Swollen tongue 25.30 12.70 15 117610 37031 70773788
Prostate cancer 25.26 12.70 10 117615 31153 70779666
Aortitis 25.25 12.70 20 117605 1391 70809428
Diaphragm muscle weakness 25.20 12.70 10 117615 174 70810645
Device related infection 25.15 12.70 113 117512 32072 70778747
Gout 25.14 12.70 4 117621 23002 70787817
Prescribed underdose 25.06 12.70 3 117622 21382 70789437
Tracheo-oesophageal fistula 25.01 12.70 14 117611 542 70810277
Haemoglobin decreased 24.83 12.70 478 117147 204681 70606138
Hip fracture 24.73 12.70 8 117617 28255 70782564
Encephalopathy 24.64 12.70 181 117444 61480 70749339
Haemophagocytic lymphohistiocytosis 24.54 12.70 80 117545 19532 70791287
Wound evisceration 24.53 12.70 9 117616 125 70810694
Rib fracture 24.37 12.70 6 117619 25350 70785469
Accidental overdose 24.29 12.70 14 117611 35107 70775712
Dysstasia 24.12 12.70 6 117619 25173 70785646
Granulocyte-colony stimulating factor level increased 24.09 12.70 5 117620 4 70810815
Gene mutation 24.04 12.70 24 117601 2267 70808552
Melanosis 24.00 12.70 7 117618 44 70810775
Rhinorrhoea 23.95 12.70 46 117579 66325 70744494
Nightmare 23.88 12.70 4 117621 22152 70788667
Acne 23.85 12.70 6 117619 24983 70785836
Medulloblastoma recurrent 23.84 12.70 9 117616 136 70810683
Sopor 23.80 12.70 11 117614 31256 70779563
Ovarian vein thrombosis 23.73 12.70 7 117618 46 70810773
Oesophageal squamous cell carcinoma 23.49 12.70 13 117612 492 70810327
Liver function test abnormal 23.29 12.70 41 117584 61105 70749714
Myeloid leukaemia 23.18 12.70 14 117611 626 70810193
Hepatic cirrhosis 23.11 12.70 11 117614 30720 70780099
Asthenia 23.08 12.70 953 116672 456713 70354106
Night sweats 23.07 12.70 23 117602 43661 70767158
Chest discomfort 22.96 12.70 117 117508 124264 70686555
Lymphadenopathy 22.91 12.70 149 117476 48642 70762177
Stem cell transplant 22.90 12.70 29 117596 3556 70807263
Varicella zoster virus infection 22.72 12.70 31 117594 4089 70806730
Nephrolithiasis 22.68 12.70 27 117598 47296 70763523
Movement disorder 22.64 12.70 6 117619 24123 70786696
Crying 22.47 12.70 4 117621 21195 70789624
Retroperitoneal neoplasm metastatic 22.42 12.70 6 117619 26 70810793
Frequent bowel movements 22.40 12.70 4 117621 21149 70789670
Tooth disorder 22.37 12.70 6 117619 23932 70786887
Pharyngeal inflammation 22.34 12.70 16 117609 956 70809863
Oral candidiasis 22.11 12.70 91 117534 24861 70785958
Fanconi syndrome acquired 22.08 12.70 24 117601 2503 70808316
Staphylococcal infection 22.05 12.70 158 117467 53246 70757573
Aortic embolus 22.01 12.70 7 117618 61 70810758
Lymphangiosis carcinomatosa 21.98 12.70 21 117604 1880 70808939
Ileus 21.95 12.70 89 117536 24148 70786671
Dyspnoea 21.92 12.70 1049 116576 769011 70041808
Myelitis transverse 21.87 12.70 20 117605 1694 70809125
Retinopathy 21.83 12.70 28 117597 3478 70807341
Medication error 21.82 12.70 38 117587 56874 70753945
Fistula of small intestine 21.78 12.70 14 117611 699 70810120
Angina pectoris 21.74 12.70 29 117596 48354 70762465
Purulent pericarditis 21.71 12.70 7 117618 64 70810755
Arteritis 21.64 12.70 15 117610 850 70809969
Gingivitis ulcerative 21.54 12.70 10 117615 259 70810560
Subclavian vein thrombosis 21.54 12.70 23 117602 2351 70808468
Product quality issue 21.40 12.70 12 117613 30549 70780270
Cystitis 21.23 12.70 28 117597 46913 70763906
Transitional cell carcinoma recurrent 21.22 12.70 5 117620 11 70810808
Renal tubular dysfunction 21.19 12.70 14 117611 733 70810086
Iron deficiency anaemia 21.15 12.70 6 117619 23066 70787753
Blood culture positive 21.11 12.70 43 117582 7883 70802936
Viral load increased 21.10 12.70 24 117601 2632 70808187
Abnormal behaviour 21.08 12.70 16 117609 34693 70776126
Ischaemic stroke 21.00 12.70 104 117521 30716 70780103
Adverse event 20.87 12.70 31 117594 49430 70761389
Enterocolitis infectious 20.82 12.70 24 117601 2670 70808149
Granulocyte count decreased 20.78 12.70 18 117607 1419 70809400
Folliculitis 20.71 12.70 24 117601 42546 70768273
Amputation stump pain 20.67 12.70 6 117619 37 70810782
Iliac artery occlusion 20.54 12.70 10 117615 289 70810530
Hyperlipidaemia 20.45 12.70 7 117618 23856 70786963
Hallucination, auditory 20.45 12.70 3 117622 18325 70792494
Ovarian cancer recurrent 20.44 12.70 12 117613 509 70810310
Bone marrow disorder 20.44 12.70 25 117600 2960 70807859
Bradycardia 20.39 12.70 122 117503 124493 70686326
Mood swings 20.39 12.70 3 117622 18283 70792536
Renal tubular injury 20.39 12.70 17 117608 1272 70809547
Hypercalcaemia of malignancy 20.35 12.70 11 117614 397 70810422
Gastrointestinal necrosis 20.30 12.70 33 117592 5085 70805734
Muscle spasticity 20.26 12.70 4 117621 19685 70791134
Subcutaneous emphysema 20.24 12.70 19 117606 1663 70809156
Conductive deafness 20.24 12.70 7 117618 81 70810738
Transplant rejection 20.22 12.70 3 117622 18168 70792651
Colitis ulcerative 20.15 12.70 16 117609 33907 70776912
Immune-mediated hepatic disorder 20.13 12.70 15 117610 953 70809866
Acute promyelocytic leukaemia 20.09 12.70 18 117607 1484 70809335
Azoospermia 20.07 12.70 8 117617 141 70810678
Metastases to pleura 20.06 12.70 17 117608 1301 70809518
Non-small cell lung cancer metastatic 20.04 12.70 15 117610 959 70809860
Metastases to abdominal cavity 20.02 12.70 12 117613 529 70810290
Jaw operation 20.02 12.70 14 117611 805 70810014
Chromaturia 20.00 12.70 7 117618 23521 70787298
Apparent mineralocorticoid excess 19.89 12.70 6 117619 43 70810776
Uterine atrophy 19.87 12.70 5 117620 16 70810803
Amnesia 19.84 12.70 35 117590 52120 70758699
Immune-mediated dermatitis 19.83 12.70 10 117615 312 70810507
Hypersomnia 19.79 12.70 5 117620 20759 70790060
Extrapyramidal disorder 19.77 12.70 5 117620 20745 70790074
Pneumonia 19.76 12.70 1192 116433 595040 70215779
Osteomyelitis 19.70 12.70 13 117612 30305 70780514
Pharyngeal stenosis 19.64 12.70 5 117620 17 70810802
Multiple organ dysfunction syndrome 19.53 12.70 270 117355 108245 70702574
Abdominal pain upper 19.50 12.70 216 117409 193386 70617433
Hyperammonaemic encephalopathy 19.49 12.70 30 117595 4413 70806406
Liver abscess 19.42 12.70 34 117591 5565 70805254
Oroticaciduria 19.38 12.70 4 117621 3 70810816
Surgery 19.30 12.70 13 117612 29976 70780843
Thymoma malignant 19.21 12.70 5 117620 19 70810800
Transient ischaemic attack 19.19 12.70 29 117596 45915 70764904
Staphylococcus test positive 19.17 12.70 35 117590 5919 70804900
Alveolar soft part sarcoma 19.16 12.70 7 117618 96 70810723
Carotid artery dissection 19.10 12.70 10 117615 338 70810481
Anti-Muellerian hormone level decreased 19.10 12.70 7 117618 97 70810722
Dropped head syndrome 19.05 12.70 9 117616 243 70810576
Retinal ischaemia 19.01 12.70 13 117612 721 70810098
Heart rate irregular 19.00 12.70 13 117612 29730 70781089
Chemotherapeutic drug level increased 18.97 12.70 10 117615 343 70810476
Chemotherapy 18.96 12.70 18 117607 1598 70809221
Mucosal toxicity 18.95 12.70 12 117613 584 70810235
Hypovolaemia 18.91 12.70 64 117561 15929 70794890
Lung abscess 18.90 12.70 27 117598 3717 70807102
Oesophageal squamous cell carcinoma metastatic 18.85 12.70 4 117621 4 70810815
Trigeminal nerve paresis 18.85 12.70 4 117621 4 70810815
Maternal death affecting foetus 18.85 12.70 4 117621 4 70810815
Bone sarcoma 18.84 12.70 7 117618 101 70810718
Sinus polyp 18.81 12.70 11 117614 463 70810356
Thrombocytopenia neonatal 18.81 12.70 5 117620 21 70810798
Cervix carcinoma recurrent 18.81 12.70 5 117620 21 70810798
Ureteric dilatation 18.69 12.70 8 117617 170 70810649
Haemoperitoneum 18.58 12.70 28 117597 4043 70806776
Mental disorder 18.50 12.70 12 117613 28228 70782591
Axillary vein thrombosis 18.48 12.70 12 117613 610 70810209
Clostridium colitis 18.40 12.70 22 117603 2544 70808275
Metastases to retroperitoneum 18.30 12.70 10 117615 369 70810450
Dystonia 18.30 12.70 5 117620 19701 70791118
Testicular cancer metastatic 18.22 12.70 6 117619 59 70810760
Vertigo 18.08 12.70 49 117576 62594 70748225
Glaucoma 17.95 12.70 4 117621 18088 70792731
Embolism arterial 17.92 12.70 16 117609 1313 70809506
Sweat gland tumour 17.91 12.70 11 117614 507 70810312
Malignant pleural effusion 17.89 12.70 24 117601 3115 70807704
Gastrointestinal ischaemia 17.68 12.70 10 117615 395 70810424
Granulocytopenia 17.67 12.70 48 117577 10599 70800220
Liver function test increased 17.67 12.70 18 117607 33829 70776990
Rash pruritic 17.64 12.70 50 117575 62941 70747878
Recurrent cancer 17.62 12.70 21 117604 2420 70808399
Squamous cell carcinoma of head and neck 17.61 12.70 9 117616 289 70810530
Laryngeal pain 17.60 12.70 33 117592 5695 70805124
Eczema 17.59 12.70 18 117607 33763 70777056
Campylobacter test positive 17.54 12.70 6 117619 67 70810752
Delusion 17.54 12.70 5 117620 19160 70791659
Eye irritation 17.51 12.70 4 117621 17784 70793035
Pericardial effusion 17.48 12.70 124 117501 41652 70769167
Procedural vomiting 17.39 12.70 12 117613 675 70810144
Adenoviral hepatitis 17.36 12.70 13 117612 832 70809987
Hot flush 17.34 12.70 35 117590 49549 70761270
Clostridium bacteraemia 17.31 12.70 9 117616 300 70810519
Synovial sarcoma 17.30 12.70 6 117619 70 70810749
Acute myelomonocytic leukaemia 17.28 12.70 9 117616 301 70810518
Sinus disorder 17.25 12.70 5 117620 18954 70791865
Extragonadal primary germ cell tumour mixed 17.23 12.70 4 117621 8 70810811
Cardiac pseudoaneurysm 17.23 12.70 6 117619 71 70810748
Morphoea 17.21 12.70 10 117615 416 70810403
Median nerve injury 17.20 12.70 5 117620 31 70810788
Neck pain 17.16 12.70 55 117570 66602 70744217
Small intestinal perforation 17.14 12.70 23 117602 2986 70807833
Joint range of motion decreased 17.13 12.70 11 117614 26015 70784804
Embryonal rhabdomyosarcoma 17.08 12.70 6 117619 73 70810746
Depressed mood 17.04 12.70 29 117596 43791 70767028
Embolism venous 16.92 12.70 26 117599 3819 70807000
Sinus congestion 16.92 12.70 4 117621 17369 70793450
Jugular vein occlusion 16.92 12.70 4 117621 9 70810810
Carotid artery thrombosis 16.91 12.70 21 117604 2525 70808294
Sarcomatoid carcinoma 16.80 12.70 5 117620 34 70810785
Neoplasm malignant 16.79 12.70 93 117532 28681 70782138
Metastases to abdominal wall 16.70 12.70 7 117618 141 70810678
Clonal haematopoiesis 16.68 12.70 5 117620 35 70810784
Portal vein thrombosis 16.61 12.70 31 117594 5331 70805488
Ganglioneuroma 16.56 12.70 7 117618 144 70810675
Restless legs syndrome 16.51 12.70 5 117620 18423 70792396
Vascular injury 16.48 12.70 14 117611 1075 70809744
Staphylococcal bacteraemia 16.46 12.70 48 117577 11034 70799785
Intentional product use issue 16.46 12.70 124 117501 120018 70690801
Venous thrombosis 16.46 12.70 35 117590 6614 70804205
Herpes zoster 16.41 12.70 79 117546 85156 70725663
Lung cancer metastatic 16.38 12.70 24 117601 3381 70807438
Organising pneumonia 16.37 12.70 45 117580 10005 70800814
Thrombophlebitis migrans 16.35 12.70 9 117616 337 70810482
Pneumonia adenoviral 16.26 12.70 10 117615 462 70810357
Sepsis pasteurella 16.21 12.70 3 117622 0 70810819
Emphysematous cholecystitis 16.21 12.70 3 117622 0 70810819
Oesophageal squamous cell carcinoma recurrent 16.21 12.70 3 117622 0 70810819
Kidney infection 16.17 12.70 6 117619 19449 70791370
Dysphonia 16.16 12.70 37 117588 50063 70760756
Disturbance in attention 16.12 12.70 29 117596 42865 70767954
Metapneumovirus bronchiolitis 16.09 12.70 4 117621 12 70810807
Paraneoplastic syndrome 16.07 12.70 13 117612 932 70809887
Leukaemic lymphoma 16.06 12.70 6 117619 88 70810731
Alopecia 16.05 12.70 232 117393 198258 70612561
Cannabinoid hyperemesis syndrome 15.99 12.70 5 117620 41 70810778
Non-small cell lung cancer stage IIIB 15.88 12.70 5 117620 42 70810777
Marchiafava-Bignami disease 15.85 12.70 4 117621 13 70810806
Bone erosion 15.78 12.70 3 117622 15170 70795649
Retinal toxicity 15.72 12.70 15 117610 1341 70809478
Depressed level of consciousness 15.71 12.70 83 117542 87348 70723471
Respiratory arrest 15.70 12.70 42 117583 53891 70756928
Skin toxicity 15.68 12.70 36 117589 7162 70803657
Device malfunction 15.67 12.70 6 117619 19078 70791741
Myositis 15.66 12.70 64 117561 17425 70793394
Gastroenteritis viral 15.65 12.70 8 117617 21447 70789372
Thrombophlebitis 15.65 12.70 32 117593 5884 70804935
Therapy interrupted 15.63 12.70 11 117614 24791 70786028
Skin exfoliation 15.62 12.70 36 117589 48590 70762229
Proctitis 15.57 12.70 24 117601 3534 70807285
Toxic leukoencephalopathy 15.43 12.70 13 117612 987 70809832
Eosinophilia 15.39 12.70 27 117598 40292 70770527
Necrosis ischaemic 15.38 12.70 13 117612 991 70809828
Cell-mediated immune deficiency 15.36 12.70 6 117619 100 70810719
Dementia 15.35 12.70 9 117616 22356 70788463
Metastases to thorax 15.35 12.70 7 117618 174 70810645
Meningitis tuberculous 15.33 12.70 14 117611 1183 70809636
Hernia 15.33 12.70 3 117622 14857 70795962
Body temperature decreased 15.25 12.70 15 117610 28657 70782162
Hypertension 15.24 12.70 374 117251 295659 70515160
Noctiphobia 15.20 12.70 4 117621 16 70810803
Gastrointestinal haemorrhage 15.18 12.70 150 117475 137258 70673561
Upper limb fracture 15.14 12.70 4 117621 16115 70794704
Hepatoblastoma 15.11 12.70 5 117620 50 70810769
Hypoxia 15.11 12.70 228 117397 93116 70717703
Fistula 15.09 12.70 46 117579 10835 70799984
Cellulitis 15.07 12.70 99 117526 98829 70711990
Muscle twitching 15.05 12.70 7 117618 19820 70790999
Death 15.03 12.70 692 116933 509369 70301450
Spinal stenosis 15.03 12.70 3 117622 14650 70796169
Metastases to the mediastinum 14.96 12.70 10 117615 534 70810285
Platelet transfusion 14.93 12.70 18 117607 2100 70808719
Immune-mediated myocarditis 14.79 12.70 11 117614 697 70810122
Neoplasm 14.75 12.70 37 117588 7787 70803032
Cerebral salt-wasting syndrome 14.73 12.70 6 117619 112 70810707
Blood loss anaemia 14.72 12.70 3 117622 14438 70796381
Pulmonary artery thrombosis 14.69 12.70 14 117611 1249 70809570
Paraneoplastic dermatomyositis 14.69 12.70 5 117620 55 70810764
Cervix cancer metastatic 14.65 12.70 4 117621 19 70810800
Myasthenic syndrome 14.65 12.70 11 117614 707 70810112
Nasopharyngeal cancer 14.61 12.70 7 117618 195 70810624
Enterobacter infection 14.53 12.70 25 117600 4035 70806784
Haematochezia 14.50 12.70 67 117558 73014 70737805
Oral fungal infection 14.46 12.70 22 117603 3204 70807615
Evans syndrome 14.46 12.70 9 117616 425 70810394
Metastases to pelvis 14.44 12.70 10 117615 566 70810253
Cytokine release syndrome 14.42 12.70 84 117541 26383 70784436
Adrenal insufficiency 14.41 12.70 81 117544 25114 70785705
Ovarian failure 14.41 12.70 10 117615 568 70810251
Pelvic fluid collection 14.41 12.70 11 117614 725 70810094
Hypoglossal nerve paresis 14.40 12.70 6 117619 119 70810700
Procedural nausea 14.34 12.70 11 117614 730 70810089
Intestinal infarction 14.33 12.70 14 117611 1288 70809531
Diabetes mellitus inadequate control 14.33 12.70 10 117615 22635 70788184
Conjunctivitis 14.31 12.70 10 117615 22626 70788193
Pneumonia salmonella 14.29 12.70 5 117620 60 70810759
Enterococcal bacteraemia 14.26 12.70 20 117605 2706 70808113
Anaplastic lymphoma kinase gene mutation 14.26 12.70 6 117619 122 70810697
Procedural pain 14.24 12.70 6 117619 18003 70792816
Poor quality sleep 14.23 12.70 8 117617 20341 70790478
Renal-limited thrombotic microangiopathy 14.16 12.70 4 117621 22 70810797
Carotid artery perforation 14.14 12.70 3 117622 3 70810816
Epithelioid mesothelioma 14.14 12.70 3 117622 3 70810816
Non-renal cell carcinoma of kidney 14.14 12.70 3 117622 3 70810816
Endothelial dysfunction 14.11 12.70 7 117618 211 70810608
Vascular pseudoaneurysm 14.08 12.70 22 117603 3279 70807540
BRAF gene mutation 14.07 12.70 5 117620 63 70810756
Thymus enlargement 14.04 12.70 6 117619 127 70810692
Laryngeal cancer stage IV 14.01 12.70 4 117621 23 70810796
B-cell lymphoma refractory 14.00 12.70 6 117619 128 70810691
Unresponsive to stimuli 13.97 12.70 42 117583 51889 70758930
Stent malfunction 13.93 12.70 5 117620 65 70810754
Vaginitis gardnerella 13.87 12.70 4 117621 24 70810795
Nephropathy 13.86 12.70 39 117586 8786 70802033
Thrombocytosis 13.83 12.70 36 117589 7748 70803071
Mood altered 13.83 12.70 5 117620 16470 70794349
Dyspnoea exertional 13.79 12.70 75 117550 78355 70732464
Culture urine positive 13.76 12.70 25 117600 4212 70806607
Adenocarcinoma 13.74 12.70 23 117602 3630 70807189
Enterococcal sepsis 13.74 12.70 19 117606 2538 70808281
Fracture 13.72 12.70 8 117617 19936 70790883
Oesophageal prosthesis insertion 13.68 12.70 3 117622 4 70810815
Abdominal pain 13.66 12.70 696 116929 341431 70469388
Skin ulcer 13.64 12.70 38 117587 48107 70762712
Neuroblastoma 13.61 12.70 8 117617 340 70810479
Rhabdoid tumour 13.60 12.70 4 117621 26 70810793
VIth nerve paresis 13.58 12.70 6 117619 138 70810681
Thrombotic thrombocytopenic purpura 13.57 12.70 31 117594 6146 70804673
Retroperitoneal neoplasm 13.47 12.70 4 117621 27 70810792
Glycosylated haemoglobin increased 13.42 12.70 6 117619 17385 70793434
Fear 13.42 12.70 9 117616 20802 70790017
Mydriasis 13.40 12.70 5 117620 16148 70794671
Tachycardia 13.37 12.70 351 117274 158195 70652624
Streptococcus test positive 13.37 12.70 17 117608 2094 70808725
Adenocarcinoma of appendix 13.34 12.70 5 117620 74 70810745
Head and neck cancer 13.33 12.70 7 117618 238 70810581
Oxygen saturation decreased 13.32 12.70 126 117499 116303 70694516
Capillary leak syndrome 13.30 12.70 22 117603 3440 70807379
Paranoia 13.29 12.70 6 117619 17282 70793537
Epiphyses premature fusion 13.28 12.70 5 117620 75 70810744
Hyperglycaemic hyperosmolar nonketotic syndrome 13.25 12.70 16 117609 1870 70808949
Gastroenteritis sapovirus 13.23 12.70 6 117619 147 70810672
Immune-mediated lung disease 13.21 12.70 15 117610 1642 70809177
Metastases to bladder 13.17 12.70 7 117618 244 70810575
Hypothermia 13.15 12.70 9 117616 20585 70790234
Hemianopia 13.15 12.70 15 117610 1650 70809169
Mania 13.14 12.70 6 117619 17168 70793651
Retroperitoneal lymphadenopathy 13.10 12.70 12 117613 1018 70809801
Systemic infection 13.10 12.70 32 117593 6625 70804194
Eye pruritus 13.08 12.70 4 117621 14643 70796176
White blood cell disorder 13.07 12.70 20 117605 2928 70807891
Diabetic ketoacidosis 13.05 12.70 20 117605 31492 70779327
Blood iron decreased 13.02 12.70 3 117622 13258 70797561
Carpal tunnel syndrome 12.99 12.70 6 117619 17051 70793768
Hepatic function abnormal 12.98 12.70 171 117454 67825 70742994
Coma 12.96 12.70 94 117531 91750 70719069
Peritoneal sarcoma 12.93 12.70 3 117622 6 70810813
Stoma site dermatitis 12.93 12.70 3 117622 6 70810813
Visual impairment 12.90 12.70 79 117546 80171 70730648
Feeling cold 12.89 12.70 14 117611 25556 70785263
Metastatic squamous cell carcinoma 12.88 12.70 9 117616 517 70810302
Germ cell cancer 12.84 12.70 6 117619 158 70810661
Blood phosphorus decreased 12.83 12.70 30 117595 6039 70804780
Delirium 12.76 12.70 72 117553 74542 70736277
Cough 12.72 12.70 427 117198 324950 70485869

FDA Adverse Event Reporting System (Pediatric)

None

Pharmacologic Action:

SourceCodeDescription
ATC L01XA01 ANTINEOPLASTIC AND IMMUNOMODULATING AGENTS
ANTINEOPLASTIC AGENTS
OTHER ANTINEOPLASTIC AGENTS
Platinum compounds
FDA EXT N0000175073 Platinum-containing Compounds
FDA EPC N0000175413 Platinum-based Drug
MeSH PA D000970 Antineoplastic Agents
MeSH PA D003432 Cross-Linking Reagents
MeSH PA D007202 Indicators and Reagents
MeSH PA D011838 Radiation-Sensitizing Agents
CHEBI has role CHEBI:25435 mutagens
CHEBI has role CHEBI:35610 antineoplastic agents
CHEBI has role CHEBI:47868 photosensitising agent
CHEBI has role CHEBI:50684 cross-linking reagents
CHEBI has role CHEBI:50902 genotoxic agent
CHEBI has role CHEBI:61015 nephrotoxins
CHEBI has role CHEBI:68495 Type I cell-death inducers
CHEBI has role CHEBI:173085 ferroptosis inducers

Drug Use | Suggest Off label Use Form| |View source of the data|

DiseaseRelationSNOMED_IDDOID
Malignant tumor of ovary indication 363443007 DOID:2394
Ovarian Germ Cell Tumor Carcinoma indication
Testicular Germ Cell Tumor indication
Invasive Bladder Malignancy indication




๐Ÿถ Veterinary Drug Use

None

๐Ÿถ Veterinary products

None

Acid dissociation constants calculated using MoKa v3.0.0

None

Orange Book patent data (new drug applications)

None

Orange Book exclusivity data (new drug applications)

None

Bioactivity Summary:

TargetClassPharosUniProtActionTypeActivity value
(-log[M])
Mechanism
action
Bioact sourceMoA source
D(3) dopamine receptor GPCR Ki 5.95 CHEMBL
Muscarinic acetylcholine receptor M5 GPCR Ki 5.37 CHEMBL
Canalicular multispecific organic anion transporter 1 Transporter WOMBAT-PK
Adenosine receptor A3 GPCR Ki 5.62 DRUG MATRIX
Multidrug resistance-associated protein 6 Transporter WOMBAT-PK
Multidrug resistance-associated protein 5 Transporter WOMBAT-PK
Epidermal growth factor receptor Kinase IC50 5.58 DRUG MATRIX
Tyrosine-protein kinase Lck Kinase IC50 4.64 DRUG MATRIX
Tyrosine-protein kinase Fyn Kinase IC50 5.32 DRUG MATRIX
C-X-C chemokine receptor type 2 GPCR Ki 5.02 DRUG MATRIX
Thromboxane-A synthase Enzyme IC50 5.03 DRUG MATRIX
C-C chemokine receptor type 2 GPCR Ki 5.15 DRUG MATRIX
Mitogen-activated protein kinase 3 Kinase IC50 5.34 DRUG MATRIX
Melanocortin receptor 5 GPCR Ki 5.22 DRUG MATRIX
Sodium/potassium-transporting ATPase subunit alpha-2 Ion channel IC50 5.03 DRUG MATRIX

External reference:

IDSource
D00275 KEGG_DRUG
4018139 VUID
N0000146476 NUI
4018139 VANDF
C0008838 UMLSCUI
CHEBI:27899 CHEBI
CPT PDB_CHEM_ID
CHEMBL1386 ChEMBL_ID
CHEMBL11359 ChEMBL_ID
CHEMBL2068237 ChEMBL_ID
DB00515 DRUGBANK_ID
5343 IUPHAR_LIGAND_ID
4426 INN_ID
Q20Q21Q62J UNII
5702198 PUBCHEM_CID
2555 RXNORM
31747 MMSL
4456 MMSL
d00195 MMSL
002641 NDDF
387318005 SNOMEDCT_US
57066004 SNOMEDCT_US
D002945 MESH_DESCRIPTOR_UI

Pharmaceutical products:

ProductCategoryIngredientsNDCFormQuantityRouteMarketingLabel
CISplatin HUMAN PRESCRIPTION DRUG LABEL 1 0143-9504 INJECTION 1 mg INTRAVENOUS ANDA 19 sections
CISplatin HUMAN PRESCRIPTION DRUG LABEL 1 0143-9505 INJECTION 1 mg INTRAVENOUS ANDA 19 sections
Cisplatin HUMAN PRESCRIPTION DRUG LABEL 1 0703-5747 INJECTION, SOLUTION 50 mg INTRAVENOUS ANDA 29 sections
Cisplatin HUMAN PRESCRIPTION DRUG LABEL 1 0703-5747 INJECTION, SOLUTION 50 mg INTRAVENOUS ANDA 29 sections
Cisplatin HUMAN PRESCRIPTION DRUG LABEL 1 0703-5748 INJECTION, SOLUTION 100 mg INTRAVENOUS ANDA 29 sections
Cisplatin HUMAN PRESCRIPTION DRUG LABEL 1 0703-5748 INJECTION, SOLUTION 100 mg INTRAVENOUS ANDA 29 sections
Cisplatin HUMAN PRESCRIPTION DRUG LABEL 1 16729-288 INJECTION 1 mg INTRAVENOUS ANDA 26 sections
CISplatin HUMAN PRESCRIPTION DRUG LABEL 1 44567-509 INJECTION, SOLUTION 1 mg INTRAVENOUS NDA 19 sections
CISplatin HUMAN PRESCRIPTION DRUG LABEL 1 44567-510 INJECTION, SOLUTION 1 mg INTRAVENOUS NDA 19 sections
CISplatin HUMAN PRESCRIPTION DRUG LABEL 1 44567-511 INJECTION, SOLUTION 1 mg INTRAVENOUS NDA 19 sections
Cisplatin HUMAN PRESCRIPTION DRUG LABEL 1 44567-530 INJECTION, POWDER, LYOPHILIZED, FOR SOLUTION 1 mg INTRAVENOUS NDA 26 sections
Cisplatin HUMAN PRESCRIPTION DRUG LABEL 1 63323-103 INJECTION, SOLUTION 1 mg INTRAVENOUS ANDA 13 sections
Cisplatin HUMAN PRESCRIPTION DRUG LABEL 1 68001-283 INJECTION 1 mg INTRAVENOUS ANDA 26 sections
CISPLATIN Human Prescription Drug Label 1 68083-162 INJECTION, SOLUTION 1 mg INTRAVENOUS ANDA 13 sections
CISPLATIN Human Prescription Drug Label 1 68083-163 INJECTION, SOLUTION 1 mg INTRAVENOUS ANDA 13 sections
Cisplatin HUMAN PRESCRIPTION DRUG LABEL 1 70860-206 INJECTION, SOLUTION 1 mg INTRAVENOUS ANDA 21 sections