cisplatin ๐Ÿถ Veterinary Use | Indications/Contra | FAERs-F | FAERs-M | Orange Bk | BioActivity |

Stem definitionDrug idCAS RN
antineoplastic agents, platinum derivatives 4392 15663-27-1

Description:

MoleculeDescription

Synonyms:

  • cisplatin
  • platinum diamminodichloride
  • cis-Platinum
An inorganic and water-soluble platinum complex. After undergoing hydrolysis, it reacts with DNA to produce both intra and interstrand crosslinks. These crosslinks appear to impair replication and transcription of DNA. The cytotoxicity of cisplatin correlates with cellular arrest in the G2 phase of the cell cycle.
  • Molecular weight: 300.05
  • Formula: Cl2H6N2Pt
  • CLOGP:
  • LIPINSKI: None
  • HAC: None
  • HDO: None
  • TPSA:
  • ALOGS:
  • ROTB: None

Drug dosage:

None

ADMET properties:

PropertyValueReference
BDDCS (Biopharmaceutical Drug Disposition Classification System) 1 Benet LZ, Broccatelli F, Oprea TI
S (Water solubility) 2.53 mg/mL Benet LZ, Broccatelli F, Oprea TI
EoM (Fraction excreted unchanged in urine) 2.30 % Benet LZ, Broccatelli F, Oprea TI
MRTD (Maximum Recommended Therapeutic Daily Dose) 4.75 ยตM/kg/day Contrera JF, Matthews EJ, Kruhlak NL, Benz RD

Approvals:

DateAgencyCompanyOrphan
Dec. 19, 1978 FDA HQ SPCLT PHARMA

FDA Adverse Event Reporting System (Female)

MedDRA adverse event termLikelihood ratioLikelihood ratio thresholdPatients taking drug having adverse eventPatients taking drug not having adverse eventPatients not taking drug having adverse eventPatients not taking drug not having adverse event
Febrile neutropenia 1196.26 15.18 945 58515 117504 63312058
Neutropenia 1169.36 15.18 1102 58358 173903 63255659
Disease progression 1092.92 15.18 910 58550 121848 63307714
Thrombocytopenia 833.89 15.18 858 58602 150299 63279263
Malignant neoplasm progression 676.97 15.18 583 58877 81538 63348024
Haematotoxicity 573.12 15.18 243 59217 9133 63420429
Mucosal inflammation 552.89 15.18 411 59049 46517 63383045
Bone marrow failure 539.09 15.18 338 59122 28952 63400610
Anaemia 474.86 15.18 924 58536 292506 63137056
Ototoxicity 426.69 15.18 120 59340 1242 63428320
Myelosuppression 419.79 15.18 267 59193 23436 63406126
Vomiting 416.66 15.18 1307 58153 558310 62871252
Pancytopenia 416.44 15.18 483 58977 96450 63333112
Leukopenia 300.26 15.18 366 59094 76924 63352638
Arthralgia 297.83 15.18 83 59377 569627 62859935
Acute myeloid leukaemia 283.46 15.18 185 59275 16962 63412600
Nausea 281.77 15.18 1553 57907 852918 62576644
Dehydration 276.16 15.18 543 58917 172811 63256751
Posterior reversible encephalopathy syndrome 264.60 15.18 178 59282 17167 63412395
Off label use 255.69 15.18 1275 58185 673187 62756375
Second primary malignancy 249.32 15.18 130 59330 7823 63421739
Hypomagnesaemia 242.49 15.18 207 59253 28530 63401032
Neutrophil count decreased 241.91 15.18 281 59179 56125 63373437
Joint swelling 238.53 15.18 18 59442 327648 63101914
Hypokalaemia 229.11 15.18 375 59085 103429 63326133
Rheumatoid arthritis 222.06 15.18 3 59457 253816 63175746
Diffuse large B-cell lymphoma recurrent 207.10 15.18 79 59381 2241 63427321
Renal salt-wasting syndrome 202.87 15.18 50 59410 292 63429270
Myelodysplastic syndrome 195.49 15.18 146 59314 16608 63412954
Neoplasm progression 195.18 15.18 204 59256 36224 63393338
Pain 192.24 15.18 248 59212 740380 62689182
Abdominal discomfort 184.52 15.18 38 59422 320847 63108715
Arthropathy 182.50 15.18 9 59451 234783 63194779
Deafness 169.41 15.18 138 59322 17819 63411743
Product dose omission issue 161.90 15.18 16 59444 234297 63195265
Metastases to central nervous system 161.43 15.18 118 59342 12987 63416575
Contraindicated product administered 161.04 15.18 11 59449 217637 63211925
Platelet count decreased 159.05 15.18 342 59118 115780 63313782
Nephropathy toxic 158.43 15.18 103 59357 9376 63420186
Peripheral swelling 155.97 15.18 30 59430 265912 63163650
Neutropenic sepsis 152.28 15.18 125 59335 16313 63413249
Musculoskeletal stiffness 150.42 15.18 5 59455 184613 63244949
Therapy partial responder 149.80 15.18 104 59356 10554 63419008
Drug resistance 149.71 15.18 143 59317 22790 63406772
Aortic thrombosis 149.10 15.18 51 59409 1048 63428514
Metastases to lung 148.51 15.18 111 59349 12639 63416923
Therapeutic product effect decreased 148.23 15.18 8 59452 193179 63236383
Sepsis 147.13 15.18 393 59067 152730 63276832
Fall 145.92 15.18 94 59366 392240 63037322
Acute kidney injury 144.13 15.18 557 58903 262858 63166704
Swelling 141.90 15.18 41 59419 275337 63154225
Gastrointestinal toxicity 141.49 15.18 89 59371 7652 63421910
Hyponatraemia 134.64 15.18 313 59147 111587 63317975
Oesophagitis 128.40 15.18 109 59351 14899 63414663
Teratoma 124.59 15.18 29 59431 127 63429435
Neurotoxicity 124.51 15.18 113 59347 16877 63412685
Pulmonary embolism 122.85 15.18 310 59150 116374 63313188
Hypocalcaemia 122.74 15.18 150 59310 31563 63397999
Ovarian germ cell teratoma 120.97 15.18 25 59435 53 63429509
Nasopharyngitis 120.14 15.18 44 59416 254213 63175349
Weight increased 120.11 15.18 47 59413 260745 63168817
Cardiotoxicity 117.79 15.18 82 59378 8356 63421206
Diffuse large B-cell lymphoma refractory 117.45 15.18 44 59416 1186 63428376
Drug hypersensitivity 114.68 15.18 75 59385 310612 63118950
Pyrexia 114.08 15.18 792 58668 469686 62959876
Urogenital fistula 113.40 15.18 29 59431 201 63429361
Wound 110.53 15.18 12 59448 163251 63266311
Pain in extremity 109.42 15.18 90 59370 331396 63098166
Headache 108.35 15.18 274 59186 632967 62796595
Neuropathy peripheral 105.36 15.18 288 59172 113379 63316183
Metastases to liver 103.35 15.18 119 59341 23520 63406042
Renal failure 103.04 15.18 292 59168 117360 63312202
Cardiomyopathy 102.36 15.18 103 59357 17481 63412081
Septic shock 101.41 15.18 205 59255 66424 63363138
Rash 100.36 15.18 237 59223 560634 62868928
Tumour lysis syndrome 99.67 15.18 76 59384 8914 63420648
Hydronephrosis 98.59 15.18 81 59379 10581 63418981
White blood cell count decreased 98.15 15.18 320 59140 138784 63290778
Pruritus 96.57 15.18 118 59342 361335 63068227
Sinusitis 93.14 15.18 48 59412 226605 63202957
Pericarditis 90.79 15.18 9 59451 131570 63297992
Condition aggravated 89.94 15.18 149 59311 402068 63027494
Contusion 89.89 15.18 16 59444 150028 63279534
Metastases to lymph nodes 88.32 15.18 68 59392 8090 63421472
Arthritis 88.27 15.18 5 59455 115916 63313646
Asthma 87.30 15.18 9 59451 127552 63302010
Product use in unapproved indication 86.10 15.18 364 59096 178716 63250846
Polyneuropathy 85.92 15.18 86 59374 14503 63415059
Hepatic enzyme increased 85.91 15.18 41 59419 202287 63227275
Drug intolerance 84.29 15.18 99 59361 308562 63121000
Disease recurrence 84.17 15.18 117 59343 27913 63401649
Insomnia 82.08 15.18 50 59410 215202 63214360
Blister 81.89 15.18 12 59448 129802 63299760
Metastases to skin 81.78 15.18 37 59423 1626 63427936
Oesophageal fistula 81.44 15.18 21 59439 151 63429411
Electrolyte imbalance 81.01 15.18 97 59363 19979 63409583
Migraine 80.12 15.18 4 59456 103342 63326220
Hypophagia 80.05 15.18 121 59339 31138 63398424
Renal impairment 80.00 15.18 222 59238 88133 63341429
Injection site pain 79.60 15.18 13 59447 129787 63299775
Discomfort 72.46 15.18 33 59427 167341 63262221
Teratoma benign 71.36 15.18 16 59444 57 63429505
Infusion related reaction 71.12 15.18 75 59385 245446 63184116
Renal tubular disorder 70.48 15.18 39 59421 2643 63426919
Muscle spasms 70.44 15.18 29 59431 156121 63273441
Metastases to bone 69.59 15.18 92 59368 20927 63408635
Ascites 68.85 15.18 131 59329 40597 63388965
Tinnitus 68.31 15.18 121 59339 35507 63394055
Palmar-plantar erythrodysaesthesia syndrome 67.51 15.18 95 59365 22920 63406642
Febrile bone marrow aplasia 66.37 15.18 55 59405 7270 63422292
Pleural effusion 65.32 15.18 214 59246 92996 63336566
Osteoarthritis 64.53 15.18 7 59453 95336 63334226
Loss of personal independence in daily activities 63.71 15.18 8 59452 97282 63332280
Gastrointestinal perforation 63.45 15.18 40 59420 3451 63426111
Lymphoma 63.02 15.18 67 59393 12120 63417442
Radiation skin injury 62.83 15.18 26 59434 917 63428645
Fibromyalgia 62.69 15.18 3 59457 80417 63349145
Cytopenia 60.38 15.18 64 59396 11537 63418025
Urticaria 59.79 15.18 41 59419 165761 63263801
Leukoencephalopathy 59.53 15.18 42 59418 4371 63425191
Renal tubular necrosis 59.13 15.18 64 59396 11814 63417748
Mobility decreased 58.83 15.18 20 59440 121139 63308423
Metastases to breast 56.70 15.18 18 59442 290 63429272
Decreased appetite 56.19 15.18 415 59045 250637 63178925
Gait disturbance 55.25 15.18 54 59406 183124 63246438
Deafness bilateral 55.23 15.18 27 59433 1415 63428147
Ovarian cancer recurrent 54.40 15.18 24 59436 993 63428569
Diarrhoea 54.19 15.18 955 58505 714411 62715151
Alopecia 52.31 15.18 153 59307 337383 63092179
Large intestine perforation 51.79 15.18 51 59409 8431 63421131
Feeling abnormal 51.79 15.18 38 59422 148354 63281208
Depression 50.46 15.18 66 59394 196426 63233136
Inappropriate antidiuretic hormone secretion 50.14 15.18 67 59393 15395 63414167
Abdominal pain 50.00 15.18 456 59004 293000 63136562
Encephalopathy 49.68 15.18 111 59349 38509 63391053
Fatigue 49.63 15.18 563 58897 887465 62542097
Metastases to peritoneum 49.33 15.18 34 59426 3408 63426154
Overdose 49.31 15.18 23 59437 115055 63314507
Bronchitis 49.03 15.18 28 59432 124907 63304655
Blood creatinine increased 48.91 15.18 187 59273 87657 63341905
Blood cholesterol increased 48.37 15.18 14 59446 94018 63335544
Injury 48.01 15.18 6 59454 73241 63356321
Deep vein thrombosis 47.99 15.18 180 59280 83620 63345942
Myasthenia gravis crisis 47.74 15.18 18 59442 494 63429068
Injection site erythema 47.41 15.18 10 59450 83164 63346398
Haemoglobin decreased 47.01 15.18 264 59196 145221 63284341
Adverse drug reaction 46.65 15.18 9 59451 79705 63349857
Suicidal ideation 46.58 15.18 3 59457 62418 63367144
Ileus 46.52 15.18 63 59397 14662 63414900
Lower respiratory tract infection 46.01 15.18 34 59426 132273 63297289
Drug clearance decreased 45.77 15.18 24 59436 1460 63428102
Anastomotic leak 45.31 15.18 17 59443 460 63429102
Hospitalisation 45.00 15.18 12 59448 85069 63344493
Peripheral artery thrombosis 44.93 15.18 26 59434 1920 63427642
Dizziness 43.54 15.18 231 59229 429694 62999868
Exposure during pregnancy 43.37 15.18 49 59411 155498 63274064
Folliculitis 43.19 15.18 7 59453 70310 63359252
Wheezing 42.70 15.18 18 59442 95577 63333985
Nasal abscess 42.37 15.18 13 59447 186 63429376
Mesenteric abscess 41.97 15.18 11 59449 85 63429477
Somnolence 40.97 15.18 65 59395 178620 63250942
Metastasis 40.91 15.18 36 59424 5161 63424401
Neutropenic colitis 40.69 15.18 29 59431 3066 63426496
Chemical peritonitis 40.29 15.18 11 59449 101 63429461
Malignant transformation 40.12 15.18 15 59445 402 63429160
Maternal exposure during pregnancy 40.00 15.18 92 59368 219970 63209592
Intentional product misuse 39.90 15.18 5 59455 60912 63368650
Blood lactate dehydrogenase increased 39.86 15.18 75 59385 23041 63406521
Cystitis haemorrhagic 39.54 15.18 32 59428 4091 63425471
Large intestinal ulcer perforation 39.39 15.18 10 59450 67 63429495
Nasal congestion 39.31 15.18 7 59453 65653 63363909
Balance disorder 39.17 15.18 15 59445 84407 63345155
Cataract 39.08 15.18 4 59456 57049 63372513
Venoocclusive liver disease 39.08 15.18 34 59426 4801 63424761
Gastrointestinal fungal infection 38.89 15.18 14 59446 336 63429226
Bicytopenia 38.89 15.18 26 59434 2479 63427083
Adverse event 38.75 15.18 8 59452 67551 63362011
Performance status decreased 38.38 15.18 30 59430 3648 63425914
Drug ineffective 38.19 15.18 720 58740 1044045 62385517
Wernicke's encephalopathy 37.79 15.18 8 59452 20 63429542
Gastric perforation 37.62 15.18 22 59438 1657 63427905
Metastases to adrenals 37.55 15.18 17 59443 748 63428814
Cardiac tamponade 37.44 15.18 33 59427 4742 63424820
Varicella zoster virus infection 37.22 15.18 26 59434 2663 63426899
Cervix neoplasm 37.14 15.18 12 59448 205 63429357
Dermatitis 36.99 15.18 61 59399 16897 63412665
Ureteric rupture 36.98 15.18 7 59453 7 63429555
Recall phenomenon 36.91 15.18 16 59444 634 63428928
Stress 36.43 15.18 9 59451 67158 63362404
Anxiety 36.36 15.18 95 59365 217446 63212116
Embryonal rhabdomyosarcoma 36.04 15.18 7 59453 9 63429553
Nephritis bacterial 36.01 15.18 8 59452 27 63429535
Asthenia 35.98 15.18 531 58929 383073 63046489
Memory impairment 35.98 15.18 27 59433 104231 63325331
Bladder perforation 35.88 15.18 11 59449 157 63429405
Injection site reaction 35.56 15.18 6 59454 58518 63371044
Treatment failure 35.54 15.18 84 59376 198959 63230603
Axillary vein thrombosis 35.36 15.18 13 59447 332 63429230
Hypoalbuminaemia 35.02 15.18 49 59411 11756 63417806
Peripheral ischaemia 34.87 15.18 32 59428 4846 63424716
Impaired healing 34.82 15.18 27 59433 102515 63327047
Metastases to abdominal wall 34.36 15.18 10 59450 118 63429444
Dysphagia 34.27 15.18 169 59291 88416 63341146
Unevaluable event 34.19 15.18 4 59456 51382 63378180
Radiation injury 34.18 15.18 14 59446 481 63429081
Stress cardiomyopathy 33.83 15.18 43 59417 9407 63420155
Melanoderma 33.67 15.18 11 59449 195 63429367
Respiratory failure 33.66 15.18 186 59274 101672 63327890
Multiple organ dysfunction syndrome 33.40 15.18 123 59337 56629 63372933
Cerebral venous thrombosis 33.34 15.18 22 59438 2052 63427510
Sinus polyp 33.33 15.18 13 59447 392 63429170
Inappropriate schedule of product administration 33.28 15.18 29 59431 103936 63325626
Malaise 33.01 15.18 241 59219 415713 63013849
Tumour haemorrhage 32.97 15.18 20 59440 1611 63427951
Cerebellar haemangioma 32.45 15.18 9 59451 88 63429474
Product use issue 31.96 15.18 103 59357 220417 63209145
Chloroma 31.89 15.18 11 59449 232 63429330
Haemolytic uraemic syndrome 31.87 15.18 23 59437 2480 63427082
Hypoaesthesia 31.74 15.18 69 59391 168324 63261238
Embolism 31.56 15.18 38 59422 7868 63421694
Gastrooesophageal reflux disease 31.44 15.18 26 59434 95613 63333949
Radiation oesophagitis 31.37 15.18 12 59448 343 63429219
Haemophagocytic lymphohistiocytosis 31.36 15.18 44 59416 10583 63418979
Herpes simplex encephalitis 31.24 15.18 12 59448 347 63429215
Malnutrition 30.67 15.18 53 59407 15245 63414317
Abortion spontaneous 30.60 15.18 4 59456 47191 63382371
Pneumonitis 30.38 15.18 87 59373 35135 63394427
Hypersensitivity 30.30 15.18 156 59304 292529 63137033
Systemic infection 30.29 15.18 29 59431 4631 63424931
Peripheral sensory neuropathy 30.05 15.18 36 59424 7415 63422147
Disseminated intravascular coagulation 29.42 15.18 59 59401 18992 63410570
Cytokine release syndrome 29.23 15.18 50 59410 14264 63415298
Wrong technique in product usage process 29.04 15.18 11 59449 62329 63367233
Chronic kidney disease 28.93 15.18 101 59359 45297 63384265
Pericardial effusion 28.65 15.18 77 59383 29981 63399581
Osteoporosis 28.64 15.18 9 59451 57329 63372233
Neoplasm recurrence 28.58 15.18 22 59438 2616 63426946
Enteritis 28.56 15.18 37 59423 8249 63421313
Bacteraemia 28.33 15.18 55 59405 17293 63412269
Metastases to abdominal cavity 28.31 15.18 12 59448 450 63429112
Arteriospasm coronary 28.30 15.18 26 59434 3942 63425620
Sleep disorder 28.30 15.18 21 59439 81545 63348017
White blood cell count abnormal 28.25 15.18 32 59428 6210 63423352
Acoustic stimulation tests abnormal 28.00 15.18 8 59452 88 63429474
Unmasking of previously unidentified disease 27.88 15.18 15 59445 961 63428601
Acquired gene mutation 27.78 15.18 15 59445 968 63428594
Enterococcal sepsis 27.67 15.18 17 59443 1401 63428161
Enterocolitis infectious 27.66 15.18 18 59442 1640 63427922
Vena cava thrombosis 27.63 15.18 20 59440 2167 63427395
Procalcitonin abnormal 27.55 15.18 6 59454 18 63429544
Intestinal perforation 27.40 15.18 44 59416 11919 63417643
Vesical fistula 27.37 15.18 8 59452 96 63429466
Alveolar soft part sarcoma 27.14 15.18 8 59452 99 63429463
Type 2 diabetes mellitus 26.99 15.18 13 59447 63855 63365707
Neutrophil count abnormal 26.79 15.18 22 59438 2870 63426692
Metastases to meninges 26.67 15.18 21 59439 2581 63426981
Pneumonia salmonella 26.41 15.18 5 59455 5 63429557
Cannabinoid hyperemesis syndrome 26.38 15.18 7 59453 57 63429505
Suicide attempt 26.36 15.18 12 59448 60906 63368656
Cholangitis 26.01 15.18 29 59431 5532 63424030
Radiation pneumonitis 25.96 15.18 17 59443 1566 63427996
Thymus enlargement 25.91 15.18 8 59452 117 63429445
Osteoradionecrosis 25.85 15.18 8 59452 118 63429444
Thrombotic microangiopathy 25.79 15.18 40 59420 10521 63419041
Clostridium bacteraemia 25.78 15.18 9 59451 197 63429365
Extremity necrosis 25.66 15.18 17 59443 1596 63427966
Incorrect dose administered 25.66 15.18 12 59448 59956 63369606
Acute respiratory distress syndrome 25.22 15.18 63 59397 23471 63406091
Klebsiella test positive 25.15 15.18 15 59445 1172 63428390
Osteosarcoma 25.08 15.18 8 59452 131 63429431
Amputation stump pain 24.96 15.18 6 59454 31 63429531
Hepatic function abnormal 24.86 15.18 84 59376 37058 63392504
Influenza like illness 24.78 15.18 16 59444 66808 63362754
Radiation proctitis 24.73 15.18 5 59455 9 63429553
Cervix carcinoma recurrent 24.43 15.18 8 59452 143 63429419
Bursitis 24.36 15.18 3 59457 37038 63392524
Jaw operation 24.08 15.18 13 59447 839 63428723
Road traffic accident 24.01 15.18 3 59457 36629 63392933
Fluid retention 23.95 15.18 13 59447 59673 63369889
Lymphopenia 23.93 15.18 53 59407 18274 63411288
Stem cell transplant 23.79 15.18 17 59443 1805 63427757
Blood pressure fluctuation 23.62 15.18 7 59453 46310 63383252
Influenza 23.56 15.18 41 59419 108681 63320881
Fistula of small intestine 23.51 15.18 10 59450 378 63429184
Cytomegalovirus oesophagitis 23.47 15.18 9 59451 259 63429303
Hypophosphataemia 23.45 15.18 40 59420 11386 63418176
Aortic embolus 23.41 15.18 6 59454 42 63429520
Malignant peritoneal neoplasm 23.27 15.18 12 59448 705 63428857
Cerebral ischaemia 23.12 15.18 30 59430 6698 63422864
Anti-Muellerian hormone level decreased 23.02 15.18 7 59453 97 63429465
Myalgia 22.96 15.18 66 59394 146463 63283099
Fanconi syndrome 22.95 15.18 15 59445 1377 63428185
Peritonitis 22.84 15.18 50 59410 17104 63412458
Urinary tract infection bacterial 22.74 15.18 26 59434 5096 63424466
Blood glucose increased 22.67 15.18 27 59433 83729 63345833
Neck pain 22.59 15.18 19 59441 69299 63360263
Lymphangioleiomyomatosis 22.54 15.18 8 59452 184 63429378
Oesophageal stenosis 22.52 15.18 21 59439 3245 63426317
Acute myelomonocytic leukaemia 22.50 15.18 8 59452 185 63429377
Vision blurred 22.45 15.18 32 59428 91892 63337670
Cytomegalovirus infection 22.36 15.18 56 59404 20896 63408666
Odynophagia 22.10 15.18 31 59429 7455 63422107
Respiratory symptom 22.08 15.18 21 59439 3326 63426236
Blood pressure increased 21.90 15.18 78 59382 161984 63267578
Pregnancy 21.89 15.18 4 59456 36832 63392730
Streptococcal bacteraemia 21.88 15.18 16 59444 1761 63427801
Femur fracture 21.87 15.18 6 59454 41750 63387812
Female genital tract fistula 21.87 15.18 31 59429 7528 63422034
Mucosal erosion 21.78 15.18 15 59445 1501 63428061
Oroticaciduria 21.66 15.18 4 59456 3 63429559
Osteosarcoma metastatic 21.65 15.18 5 59455 21 63429541
Drug reaction with eosinophilia and systemic symptoms 21.62 15.18 3 59457 33833 63395729
Burning sensation 21.62 15.18 12 59448 54395 63375167
Failure to thrive 21.53 15.18 30 59430 7168 63422394
Median nerve injury 21.46 15.18 5 59455 22 63429540
Ovarian vein thrombosis 21.43 15.18 6 59454 61 63429501
Therapy responder 21.32 15.18 9 59451 334 63429228
Cerebral salt-wasting syndrome 21.17 15.18 6 59454 64 63429498
Maternal death affecting foetus 21.13 15.18 4 59456 4 63429558
Product quality issue 21.09 15.18 4 59456 35861 63393701
Oesophageal infection 20.80 15.18 9 59451 355 63429207
Medulloblastoma recurrent 20.76 15.18 6 59454 69 63429493
Plasma cell leukaemia 20.67 15.18 13 59447 1117 63428445
Blood magnesium decreased 20.53 15.18 41 59419 13157 63416405
Sarcomatoid carcinoma 20.46 15.18 5 59455 28 63429534
Gastric disorder 20.28 15.18 5 59455 37364 63392198
Aspergilloma 20.24 15.18 8 59452 250 63429312
Vaginitis gardnerella 20.17 15.18 5 59455 30 63429532
Joint stiffness 20.16 15.18 7 59453 41862 63387700
VIth nerve paresis 20.01 15.18 6 59454 79 63429483
Pulmonary vascular disorder 19.92 15.18 9 59451 394 63429168
Peritoneal gliomatosis 19.86 15.18 4 59456 7 63429555
Radiation mucositis 19.76 15.18 5 59455 33 63429529
Pain in jaw 19.72 15.18 8 59452 43488 63386074
Leukaemic lymphoma 19.68 15.18 6 59454 84 63429478
Bronchial fistula 19.63 15.18 5 59455 34 63429528
Superior sagittal sinus thrombosis 19.42 15.18 11 59449 780 63428782
Dry eye 19.31 15.18 7 59453 40754 63388808
Gastrointestinal necrosis 19.31 15.18 18 59442 2780 63426782
Lip swelling 19.28 15.18 3 59457 31060 63398502
Salivary gland cancer 19.22 15.18 7 59453 174 63429388
Blood sodium decreased 19.10 15.18 58 59402 24194 63405368
Lymphocele 19.09 15.18 11 59449 806 63428756
Ear infection 19.08 15.18 6 59454 38207 63391355
Granulocytopenia 19.04 15.18 25 59435 5647 63423915
Marchiafava-Bignami disease 18.90 15.18 4 59456 10 63429552
Blood creatine phosphokinase increased 18.75 15.18 3 59457 30427 63399135
Hiccups 18.66 15.18 16 59444 2215 63427347
Respiratory distress 18.66 15.18 72 59388 33879 63395683
Aortitis 18.62 15.18 12 59448 1075 63428487
Metastases to pelvis 18.58 15.18 9 59451 462 63429100
Gastroenteritis radiation 18.57 15.18 9 59451 463 63429099
Adrenocortical carcinoma 18.50 15.18 5 59455 44 63429518
Vascular compression 18.47 15.18 7 59453 195 63429367
Pelvic fluid collection 18.38 15.18 11 59449 865 63428697
Obesity 18.35 15.18 3 59457 29949 63399613
Sweat gland tumour 18.33 15.18 6 59454 107 63429455
Intentional product use issue 18.33 15.18 60 59400 127832 63301730
Hypoacusis 18.31 15.18 57 59403 24094 63405468
Therapy interrupted 18.29 15.18 4 59456 32451 63397111
Joint range of motion decreased 18.27 15.18 4 59456 32424 63397138
Confusional state 18.22 15.18 138 59322 236242 63193320
Death 18.17 15.18 469 58991 373912 63055650
Uterine atrophy 18.11 15.18 5 59455 48 63429514
Tumour associated fever 18.06 15.18 8 59452 334 63429228
Hypoglossal nerve paresis 18.03 15.18 6 59454 113 63429449
Candida infection 18.00 15.18 63 59397 28288 63401274
Urinary tract toxicity 17.92 15.18 3 59457 0 63429562
Gait inability 17.90 15.18 14 59446 52945 63376617
Transdifferentiation of neoplasm 17.89 15.18 4 59456 14 63429548
Sedation 17.82 15.18 7 59453 38802 63390760
Tachycardia 17.79 15.18 179 59281 117977 63311585
Hypoglycaemia 17.76 15.18 18 59442 60047 63369515
Purulent pericarditis 17.67 15.18 5 59455 53 63429509
Neurosensory hypoacusis 17.58 15.18 7 59453 223 63429339
Ill-defined disorder 17.56 15.18 31 59429 81724 63347838
Ovarian disorder 17.51 15.18 10 59450 720 63428842
Palpitations 17.51 15.18 51 59409 112719 63316843
Central nervous system vasculitis 17.51 15.18 11 59449 943 63428619
Refeeding syndrome 17.50 15.18 5 59455 55 63429507
Eye pain 17.48 15.18 5 59455 33849 63395713
Heart rate increased 17.43 15.18 39 59421 94199 63335363
Drug clearance increased 17.37 15.18 6 59454 127 63429435
Blood lactate dehydrogenase abnormal 17.36 15.18 8 59452 367 63429195
Central obesity 17.35 15.18 12 59448 1209 63428353
Hepatic lesion 17.34 15.18 22 59438 4803 63424759
Fungal oesophagitis 17.34 15.18 10 59450 734 63428828
Surgery 17.30 15.18 6 59454 35906 63393656
Urogenital disorder 17.26 15.18 5 59455 58 63429504
Blood pressure immeasurable 17.26 15.18 12 59448 1220 63428342
Sinus tachycardia 17.24 15.18 56 59404 24212 63405350
Deafness neurosensory 17.24 15.18 22 59438 4833 63424729
Chronic obstructive pulmonary disease 17.18 15.18 20 59440 62666 63366896
Roseolovirus test positive 17.18 15.18 5 59455 59 63429503
Cardiopulmonary failure 17.17 15.18 19 59441 3593 63425969
Liver abscess 17.13 15.18 17 59443 2837 63426725
Fluid intake reduced 17.05 15.18 19 59441 3622 63425940
Renal-limited thrombotic microangiopathy 17.03 15.18 5 59455 61 63429501
Throat irritation 16.95 15.18 7 59453 37640 63391922
Tumour thrombosis 16.92 15.18 4 59456 19 63429543
Melanosis 16.92 15.18 4 59456 19 63429543
Ureteric obstruction 16.85 15.18 14 59446 1856 63427706
Rhinorrhoea 16.84 15.18 22 59438 65555 63364007
Myasthenic syndrome 16.75 15.18 7 59453 253 63429309
Tearfulness 16.70 15.18 20 59440 4119 63425443
Metastases to pleura 16.70 15.18 13 59447 1572 63427990
Hallucination 16.70 15.18 16 59444 54801 63374761
Abdominal compartment syndrome 16.62 15.18 9 59451 584 63428978
Necrosis 16.61 15.18 23 59437 5464 63424098
Ovarian failure 16.59 15.18 12 59448 1298 63428264
Tumour invasion 16.59 15.18 6 59454 146 63429416
Necrotising colitis 16.48 15.18 9 59451 594 63428968
Low cardiac output syndrome 16.48 15.18 8 59452 413 63429149
Muscular weakness 16.45 15.18 59 59401 122294 63307268
Haemoglobin abnormal 16.42 15.18 22 59438 5066 63424496
Hypoxia 16.40 15.18 104 59356 59688 63369874
Underdose 16.27 15.18 3 59457 27453 63402109
Small cell lung cancer 16.24 15.18 13 59447 1636 63427926
Renal tubular dysfunction 16.23 15.18 8 59452 427 63429135
Skin toxicity 16.17 15.18 21 59439 4693 63424869
Staphylococcal infection 16.15 15.18 79 59381 41177 63388385
Metastases to retroperitoneum 16.15 15.18 6 59454 158 63429404
Aorto-oesophageal fistula 16.14 15.18 4 59456 24 63429538
Tracheal stenosis 16.11 15.18 6 59454 159 63429403
Metastatic neoplasm 16.10 15.18 20 59440 4275 63425287
Blood culture positive 16.09 15.18 21 59439 4714 63424848
Limb discomfort 16.08 15.18 4 59456 29712 63399850
Clostridium difficile colitis 16.02 15.18 49 59411 20520 63409042
VIth nerve disorder 15.85 15.18 3 59457 3 63429559
Stomatitis 15.81 15.18 199 59261 138526 63291036
Stent malfunction 15.78 15.18 5 59455 80 63429482
Bacterial sepsis 15.76 15.18 19 59441 3939 63425623
Pseudomonal sepsis 15.72 15.18 15 59445 2386 63427176
Blood phosphorus decreased 15.53 15.18 20 59440 4433 63425129
Neuromyopathy 15.49 15.18 9 59451 670 63428892
Metastases to the mediastinum 15.36 15.18 8 59452 480 63429082
Acute promyelocytic leukaemia 15.31 15.18 10 59450 917 63428645
Electrocardiogram ST segment depression 15.20 15.18 16 59444 2861 63426701
Drug-device interaction 15.18 15.18 5 59455 91 63429471

FDA Adverse Event Reporting System (Male)

MedDRA adverse event termLikelihood ratioLikelihood ratio thresholdPatients taking drug having adverse eventPatients taking drug not having adverse eventPatients not taking drug having adverse eventPatients not taking drug not having adverse event
Febrile neutropenia 1417.99 13.27 1713 84514 135136 34735568
Neutropenia 1019.04 13.27 1566 84661 155212 34715492
Disease progression 848.28 13.27 1181 85046 106896 34763808
Mucosal inflammation 763.61 13.27 685 85542 37937 34832767
Malignant neoplasm progression 602.26 13.27 902 85325 87144 34783560
Thrombocytopenia 602.23 13.27 1243 84984 155004 34715700
Myelosuppression 462.36 13.27 382 85845 18883 34851821
Pancytopenia 429.95 13.27 810 85417 94347 34776357
Bone marrow failure 376.86 13.27 411 85816 28842 34841862
Dehydration 351.56 13.27 900 85327 129069 34741635
Leukopenia 343.95 13.27 582 85645 62274 34808430
Haematotoxicity 342.50 13.27 227 86000 7967 34862737
Neoplasm progression 292.49 13.27 323 85904 22977 34847727
Stomatitis 290.78 13.27 436 85791 42078 34828626
Vomiting 281.92 13.27 1282 84945 246339 34624365
Neutropenic sepsis 267.45 13.27 242 85985 13525 34857179
Anaemia 262.50 13.27 1204 85023 232131 34638573
Acute myeloid leukaemia 249.82 13.27 265 85962 18005 34852699
Dysphagia 247.37 13.27 503 85724 61878 34808826
Therapy partial responder 246.05 13.27 198 86029 9418 34861286
Nausea 231.51 13.27 1530 84697 338378 34532326
Renal salt-wasting syndrome 230.78 13.27 68 86159 277 34870427
Drug abuse 228.57 13.27 3 86224 99093 34771611
Nephropathy toxic 228.41 13.27 213 86014 12375 34858329
Second primary malignancy 226.84 13.27 174 86053 7712 34862992
Completed suicide 226.31 13.27 3 86224 98165 34772539
Product dose omission issue 224.60 13.27 19 86208 119692 34751012
Off label use 220.78 13.27 1775 84452 417749 34452955
Neutrophil count decreased 216.89 13.27 424 85803 50680 34820024
Arthralgia 193.10 13.27 89 86138 169952 34700752
Fall 180.32 13.27 142 86085 202743 34667961
Aortic thrombosis 176.55 13.27 68 86159 710 34869994
Pulmonary embolism 169.81 13.27 547 85680 89199 34781505
Myelodysplastic syndrome 154.70 13.27 213 86014 18995 34851709
Tumour lysis syndrome 153.98 13.27 200 86027 16859 34853845
Drug interaction 144.05 13.27 209 86018 225737 34644967
Ototoxicity 142.60 13.27 77 86150 1840 34868864
Decreased appetite 139.24 13.27 791 85436 165601 34705103
Pyrexia 132.40 13.27 1327 84900 331686 34539018
Cardiotoxicity 127.16 13.27 108 86119 5540 34865164
Headache 122.59 13.27 191 86036 200444 34670260
Overdose 119.30 13.27 38 86189 91021 34779683
Hyponatraemia 118.45 13.27 460 85767 82231 34788473
Diffuse large B-cell lymphoma refractory 114.60 13.27 58 86169 1208 34869496
White blood cell count decreased 111.68 13.27 499 85728 94946 34775758
Weight increased 111.37 13.27 45 86182 92988 34777716
Diffuse large B-cell lymphoma recurrent 110.27 13.27 79 86148 3149 34867555
Acute kidney injury 107.28 13.27 1186 85041 303802 34566902
Septic shock 105.64 13.27 403 85824 71431 34799273
Anastomotic leak 104.61 13.27 44 86183 587 34870117
Hypomagnesaemia 103.39 13.27 190 86037 21661 34849043
Depression 102.32 13.27 56 86171 97042 34773662
Oesophagitis 102.21 13.27 144 86083 13117 34857587
Arterial thrombosis 102.07 13.27 57 86170 1458 34869246
Febrile bone marrow aplasia 101.58 13.27 113 86114 8096 34862608
Rhabdomyolysis 99.50 13.27 23 86204 68140 34802564
Intentional product misuse 95.23 13.27 4 86223 45607 34825097
Radiation skin injury 94.41 13.27 43 86184 702 34870002
Hospitalisation 94.18 13.27 14 86213 56888 34813816
Platelet count decreased 91.52 13.27 556 85671 119161 34751543
Anxiety 91.50 13.27 67 86160 99361 34771343
Metastases to central nervous system 91.46 13.27 107 86120 8098 34862606
Aorto-oesophageal fistula 90.90 13.27 22 86205 31 34870673
Cardiac failure congestive 90.72 13.27 46 86181 83224 34787480
Muscle spasms 90.21 13.27 36 86191 74965 34795739
Peripheral swelling 88.42 13.27 39 86188 76502 34794202
Sepsis 87.58 13.27 706 85521 165855 34704849
Hypophagia 87.26 13.27 187 86040 23835 34846869
Insomnia 85.70 13.27 78 86149 103829 34766875
Deafness 84.86 13.27 121 86106 11144 34859560
Renal impairment 84.70 13.27 458 85769 94055 34776649
Metastases to lung 83.67 13.27 109 86118 9211 34861493
Nasopharyngitis 83.47 13.27 34 86193 69934 34800770
Condition aggravated 82.51 13.27 224 86003 191972 34678732
Joint swelling 82.04 13.27 23 86204 59867 34810837
Osteoradionecrosis 80.59 13.27 22 86205 63 34870641
Inappropriate antidiuretic hormone secretion 80.35 13.27 126 86101 12627 34858077
Blood pressure increased 80.24 13.27 60 86167 88042 34782662
Gastric perforation 80.01 13.27 59 86168 2461 34868243
Suicide attempt 79.80 13.27 4 86223 39112 34831592
Suicidal ideation 79.72 13.27 5 86222 40383 34830321
Myalgia 79.59 13.27 55 86172 84055 34786649
Peripheral artery thrombosis 78.88 13.27 57 86170 2303 34868401
Odynophagia 78.86 13.27 82 86145 5439 34865265
Peripheral ischaemia 76.84 13.27 82 86145 5605 34865099
Musculoskeletal stiffness 76.07 13.27 12 86215 46668 34824036
Hypokalaemia 75.44 13.27 314 85913 57900 34812804
Inappropriate schedule of product administration 74.75 13.27 30 86197 62266 34808438
Pain in extremity 72.91 13.27 125 86102 126388 34744316
Pneumonitis 72.79 13.27 216 86011 33662 34837042
Vena cava thrombosis 71.66 13.27 42 86185 1180 34869524
Product use in unapproved indication 70.03 13.27 513 85714 116986 34753718
Tinnitus 68.96 13.27 153 86074 19965 34850739
Drug reaction with eosinophilia and systemic symptoms 68.56 13.27 3 86224 33009 34837695
Neutropenic colitis 68.49 13.27 59 86168 3085 34867619
Oesophageal fistula 67.28 13.27 26 86201 274 34870430
Asthma 67.22 13.27 12 86215 42644 34828060
Hepatitis B 66.65 13.27 78 86149 5905 34864799
Blood lactate dehydrogenase increased 65.87 13.27 163 86064 22827 34847877
Psoriasis 65.50 13.27 9 86218 38803 34831901
Deafness neurosensory 64.83 13.27 55 86172 2816 34867888
Disease recurrence 64.38 13.27 155 86072 21335 34849369
General physical health deterioration 64.29 13.27 538 85689 127731 34742973
Rheumatoid arthritis 64.22 13.27 9 86218 38229 34832475
Portal venous gas 64.07 13.27 27 86200 362 34870342
Cardiac disorder 64.04 13.27 14 86213 43112 34827592
Radiation pneumonitis 62.56 13.27 52 86175 2588 34868116
Wheezing 62.38 13.27 13 86214 41389 34829315
Renal failure 61.96 13.27 541 85686 130016 34740688
B-cell lymphoma recurrent 61.78 13.27 33 86194 771 34869933
Aplasia 61.72 13.27 66 86161 4522 34866182
Death 60.31 13.27 660 85567 397389 34473315
Splenic infarction 60.14 13.27 46 86181 2029 34868675
Neuropathy peripheral 59.99 13.27 381 85846 82882 34787822
Pruritus 59.74 13.27 167 86060 141814 34728890
Heart rate decreased 59.58 13.27 5 86222 31740 34838964
Bacterial translocation 59.33 13.27 25 86202 335 34870369
Injection site pain 59.27 13.27 12 86215 38993 34831711
Gastrointestinal toxicity 59.18 13.27 51 86176 2668 34868036
Colitis 58.95 13.27 216 86011 37534 34833170
Dermatitis 58.89 13.27 93 86134 9375 34861329
Prostate cancer 58.61 13.27 13 86214 39636 34831068
Deep vein thrombosis 58.28 13.27 316 85911 64932 34805772
Dizziness 57.84 13.27 310 85917 218211 34652493
Hiccups 57.22 13.27 95 86132 9987 34860717
Hallucination 56.74 13.27 28 86199 51470 34819234
Oesophageal stenosis 56.04 13.27 41 86186 1689 34869015
Somnolence 55.94 13.27 119 86108 110997 34759707
Aggression 55.18 13.27 14 86213 38950 34831754
Tremor 54.88 13.27 74 86153 82513 34788191
Influenza 54.73 13.27 27 86200 49639 34821065
Tumour necrosis 54.58 13.27 36 86191 1252 34869452
Gait disturbance 53.87 13.27 79 86148 85061 34785643
Metastases to liver 53.86 13.27 110 86117 13553 34857151
Vision blurred 53.73 13.27 23 86204 45940 34824764
Bacteraemia 53.56 13.27 137 86090 19580 34851124
Oesophagobronchial fistula 52.21 13.27 19 86208 167 34870537
Malignant transformation 51.89 13.27 30 86197 821 34869883
Feeling abnormal 51.48 13.27 48 86179 63187 34807517
Radiation oesophagitis 51.34 13.27 24 86203 417 34870287
Mobility decreased 50.81 13.27 7 86220 30121 34840583
Hypertension 50.62 13.27 170 86057 136273 34734431
Osteosarcoma 50.48 13.27 21 86206 272 34870432
Progressive multifocal leukoencephalopathy 50.14 13.27 88 86139 9676 34861028
Electrolyte imbalance 49.83 13.27 110 86117 14302 34856402
Arthritis 48.99 13.27 9 86218 31337 34839367
Wrong technique in product usage process 48.94 13.27 14 86213 35972 34834732
Acute respiratory distress syndrome 48.75 13.27 158 86069 25811 34844893
Blood creatine phosphokinase increased 48.50 13.27 25 86202 44832 34825872
Thrombotic microangiopathy 48.48 13.27 91 86136 10539 34860165
Incorrect dose administered 47.80 13.27 20 86207 40495 34830209
Urticaria 47.72 13.27 50 86177 62327 34808377
Blood pressure fluctuation 47.32 13.27 4 86223 25245 34845459
Memory impairment 47.05 13.27 24 86203 43294 34827410
Respiratory failure 46.94 13.27 441 85786 108131 34762573
Metastases to lymph nodes 46.71 13.27 58 86169 4670 34866034
Coronary artery disease 46.46 13.27 31 86196 48274 34822430
Pulmonary vascular disorder 46.45 13.27 26 86201 668 34870036
Ameloblastoma 46.29 13.27 15 86212 89 34870615
Hypocalcaemia 45.80 13.27 148 86079 24141 34846563
Leukoencephalopathy 45.37 13.27 54 86173 4161 34866543
Interstitial lung disease 45.33 13.27 296 85931 64986 34805718
Atypical haemolytic uraemic syndrome 45.14 13.27 20 86207 305 34870399
Abdominal discomfort 44.62 13.27 49 86178 59786 34810918
Drug hypersensitivity 44.17 13.27 82 86145 80447 34790257
Mantle cell lymphoma recurrent 44.15 13.27 26 86201 737 34869967
Carotid artery thrombosis 43.45 13.27 20 86207 335 34870369
Foetal exposure during pregnancy 43.07 13.27 20 86207 38081 34832623
Large intestine perforation 42.84 13.27 76 86151 8427 34862277
Renal tubular disorder 42.77 13.27 55 86172 4588 34866116
Neoplasm recurrence 42.61 13.27 39 86188 2210 34868494
Adverse drug reaction 42.61 13.27 10 86217 29332 34841372
Cytomegalovirus oesophagitis 42.38 13.27 22 86205 484 34870220
Embolism arterial 42.31 13.27 24 86203 633 34870071
Azoospermia 42.26 13.27 21 86206 420 34870284
Salivary gland cancer 42.23 13.27 19 86208 301 34870403
Product prescribing error 41.97 13.27 4 86223 22923 34847781
Angioedema 41.66 13.27 20 86207 37354 34833350
Hyperammonaemic encephalopathy 41.52 13.27 39 86188 2285 34868419
Intestinal ischaemia 41.00 13.27 71 86156 7723 34862981
Renal infarct 40.97 13.27 31 86196 1345 34869359
Influenza like illness 40.96 13.27 9 86218 27625 34843079
Embolism 40.77 13.27 71 86156 7758 34862946
Balance disorder 40.59 13.27 25 86202 40629 34830075
Pulmonary arteriopathy 40.28 13.27 13 86214 76 34870628
Metastasis 39.61 13.27 50 86177 4094 34866610
Hypoglycaemia 39.38 13.27 46 86181 54594 34816110
Pain 39.15 13.27 320 85907 204355 34666349
Pulmonary toxicity 39.09 13.27 61 86166 6086 34864618
Enteritis 38.76 13.27 71 86156 8071 34862633
Tumour perforation 38.60 13.27 18 86209 311 34870393
Pneumatosis intestinalis 38.56 13.27 48 86179 3875 34866829
Electrocardiogram QT prolonged 38.42 13.27 27 86200 40925 34829779
Therapeutic product effect decreased 38.10 13.27 19 86208 34724 34835980
Anastomotic complication 37.96 13.27 19 86208 386 34870318
Cataract 37.87 13.27 9 86218 26177 34844527
Bronchial fistula 37.54 13.27 15 86212 174 34870530
Nasal congestion 37.39 13.27 6 86221 23051 34847653
Blood stem cell transplant failure 37.23 13.27 19 86208 403 34870301
Unevaluable event 37 13.27 17 86210 32573 34838131
Sleep disorder 36.81 13.27 16 86211 31672 34839032
Osteoarthritis 36.75 13.27 4 86223 20638 34850066
Confusional state 36.72 13.27 207 86020 143953 34726751
Rash 36.60 13.27 362 85865 222390 34648314
Myocardial infarction 36.47 13.27 164 86063 120921 34749783
Depressed mood 36.36 13.27 3 86224 19314 34851390
International normalised ratio increased 36.13 13.27 38 86189 47289 34823415
Chest discomfort 36.07 13.27 49 86178 54481 34816223
Lymphopenia 35.89 13.27 105 86122 16230 34854474
Back pain 35.46 13.27 167 86060 121622 34749082
Chronic obstructive pulmonary disease 35.44 13.27 41 86186 48877 34821827
Contusion 35.42 13.27 23 86204 36341 34834363
Toxicity to various agents 35.31 13.27 320 85907 200042 34670662
Bradycardia 35.30 13.27 84 86143 75334 34795370
Radiation mucositis 35.27 13.27 15 86212 206 34870498
Chemotherapy 35.27 13.27 21 86206 608 34870096
Blood sodium decreased 35.26 13.27 104 86123 16147 34854557
Cytopenia 35.17 13.27 89 86138 12634 34858070
Tracheo-oesophageal fistula 35.15 13.27 19 86208 455 34870249
Sedation 35.14 13.27 5 86222 21001 34849703
Neurosensory hypoacusis 35.05 13.27 7 86220 0 34870704
Teratoma 34.90 13.27 9 86218 19 34870685
Lymphadenopathy 34.88 13.27 151 86076 28312 34842392
Blood glucose increased 34.78 13.27 70 86157 66648 34804056
Recall phenomenon 34.48 13.27 20 86207 551 34870153
Cystitis haemorrhagic 34.24 13.27 55 86172 5624 34865080
Tumour haemorrhage 33.63 13.27 39 86188 2923 34867781
Alopecia 33.61 13.27 134 86093 24221 34846483
Blood creatinine increased 33.48 13.27 370 85857 94606 34776098
Chloroma 33.30 13.27 19 86208 507 34870197
Neurotoxicity 33.28 13.27 109 86118 17901 34852803
Acquired gene mutation 32.75 13.27 27 86200 1328 34869376
Serotonin syndrome 32.75 13.27 5 86222 19928 34850776
Nephrolithiasis 32.65 13.27 17 86210 30316 34840388
Empyema 32.46 13.27 40 86187 3196 34867508
Blood cholesterol increased 31.88 13.27 6 86221 20537 34850167
Sinusitis 31.87 13.27 33 86194 41369 34829335
Dyskinesia 31.83 13.27 8 86219 22405 34848299
Malaise 31.78 13.27 299 85928 185526 34685178
Bicytopenia 31.55 13.27 34 86193 2350 34868354
Hypoacusis 31.34 13.27 100 86127 16201 34854503
Gout 31.25 13.27 5 86222 19248 34851456
Hepatitis B reactivation 31.09 13.27 43 86184 3848 34866856
Pancreatitis 31.08 13.27 30 86197 38861 34831843
Blood pressure systolic increased 31.08 13.27 9 86218 22943 34847761
Blood HIV RNA increased 30.76 13.27 25 86202 1205 34869499
Radiation injury 30.58 13.27 18 86209 510 34870194
Immune-mediated hepatic disorder 30.35 13.27 23 86204 1000 34869704
Injury 30.13 13.27 7 86220 20680 34850024
Lymphoma 30.01 13.27 83 86144 12424 34858280
Localised infection 29.86 13.27 4 86223 17583 34853121
Osteosarcoma recurrent 29.81 13.27 8 86219 21 34870683
Loss of personal independence in daily activities 29.67 13.27 23 86204 33156 34837548
Palmar-plantar erythrodysaesthesia syndrome 29.57 13.27 100 86127 16695 34854009
Diarrhoea 29.48 13.27 1208 85019 388704 34482000
Pharyngeal inflammation 29.23 13.27 15 86212 322 34870382
Drug resistance 29.10 13.27 134 86093 25793 34844911
Papillary thyroid cancer 29.08 13.27 19 86208 650 34870054
Flagellate dermatitis 28.97 13.27 10 86217 74 34870630
Arterial occlusive disease 28.95 13.27 44 86183 4290 34866414
Oedema peripheral 28.92 13.27 175 86052 119637 34751067
Gait inability 28.36 13.27 8 86219 20750 34849954
Gastrooesophageal reflux disease 28.33 13.27 31 86196 37893 34832811
Diabetes mellitus 28.19 13.27 45 86182 46828 34823876
Hepatic candidiasis 28.12 13.27 9 86218 51 34870653
Spinal column injury 27.81 13.27 18 86209 606 34870098
Haematochezia 27.68 13.27 45 86182 46489 34824215
Lactic acidosis 27.58 13.27 27 86200 34745 34835959
Peritonitis 27.55 13.27 96 86131 16269 34854435
Liver function test abnormal 27.21 13.27 22 86205 31052 34839652
Oesophageal perforation 27.14 13.27 23 86204 1176 34869528
Product administration error 27.08 13.27 4 86223 16340 34854364
Blindness cortical 27.06 13.27 15 86212 378 34870326
Hyperhidrosis 26.90 13.27 96 86131 75596 34795108
Abnormal behaviour 26.86 13.27 14 86213 24955 34845749
Abdominal neoplasm 26.78 13.27 15 86212 386 34870318
Primitive neuroectodermal tumour 26.63 13.27 9 86218 62 34870642
Emotional distress 26.53 13.27 3 86224 15023 34855681
Arteriospasm coronary 26.46 13.27 37 86190 3345 34867359
Thrombophlebitis 26.34 13.27 36 86191 3186 34867518
Labelled drug-drug interaction medication error 26.33 13.27 3 86224 14936 34855768
Wound 26.16 13.27 3 86224 14861 34855843
Swelling 26.11 13.27 40 86187 42326 34828378
Upper respiratory tract infection 25.84 13.27 26 86201 33033 34837671
Diaphragm muscle weakness 25.74 13.27 11 86216 153 34870551
Sleep apnoea syndrome 25.68 13.27 9 86218 20312 34850392
Disseminated intravascular coagulation 25.41 13.27 114 86113 21702 34849002
Road traffic accident 25.23 13.27 6 86221 17444 34853260
Cerebral infarction 25.19 13.27 134 86093 27321 34843383
Lymphadenopathy mediastinal 25.10 13.27 31 86196 2482 34868222
Extravasation 25.09 13.27 27 86200 1863 34868841
Irritability 24.90 13.27 15 86212 24675 34846029
Visual impairment 24.88 13.27 31 86196 35771 34834933
Transient ischaemic attack 24.87 13.27 19 86208 27594 34843110
Fluid retention 24.86 13.27 18 86209 26869 34843835
Hot flush 24.61 13.27 7 86220 18059 34852645
Dermatitis acneiform 24.59 13.27 50 86177 6139 34864565
Agitation 24.49 13.27 67 86160 57332 34813372
Refeeding syndrome 24.48 13.27 7 86220 25 34870679
Psychotic disorder 24.45 13.27 15 86212 24437 34846267
Superior mesenteric artery syndrome 24.35 13.27 9 86218 83 34870621
Therapy cessation 24.22 13.27 6 86221 16967 34853737
Testicular malignant teratoma 24.18 13.27 6 86221 10 34870694
Enterocolitis 24.15 13.27 58 86169 7968 34862736
Angina pectoris 24.14 13.27 25 86202 31338 34839366
Cholelithiasis 24.05 13.27 11 86216 21137 34849567
Oral candidiasis 23.93 13.27 75 86152 12035 34858669
Cerebral ischaemia 23.86 13.27 50 86177 6272 34864432
Peripheral sensory neuropathy 23.82 13.27 52 86175 6708 34863996
Herpes zoster 23.68 13.27 30 86197 34369 34836335
Accidental overdose 23.66 13.27 10 86217 20130 34850574
Muscular weakness 23.61 13.27 96 86131 72801 34797903
Myoclonus 23.50 13.27 4 86223 14721 34855983
Granulocyte count decreased 23.47 13.27 18 86209 797 34869907
Disturbance in attention 23.18 13.27 18 86209 25927 34844777
Immune-mediated dermatitis 23.15 13.27 13 86214 336 34870368
Illness 23.15 13.27 3 86224 13526 34857178
Drug intolerance 22.90 13.27 73 86154 59497 34811207
Refractory cancer 22.90 13.27 10 86217 147 34870557
Retinal toxicity 22.89 13.27 14 86213 426 34870278
Medulloblastoma recurrent 22.64 13.27 8 86219 64 34870640
Cerebral venous sinus thrombosis 22.63 13.27 15 86212 526 34870178
Adenoviral hepatitis 22.55 13.27 15 86212 529 34870175
Cerebral venous thrombosis 22.48 13.27 17 86210 737 34869967
Deafness bilateral 22.45 13.27 20 86207 1094 34869610
BK virus infection 22.38 13.27 46 86181 5692 34865012
Paraneoplastic syndrome 22.33 13.27 15 86212 538 34870166
Performance status decreased 22.17 13.27 38 86189 4099 34866605
COVID-19 22.17 13.27 107 86120 77443 34793261
Granulocyte-colony stimulating factor level increased 22.11 13.27 5 86222 4 34870700
Bronchitis 21.89 13.27 44 86183 41919 34828785
EGFR gene mutation 21.75 13.27 10 86217 167 34870537
Meningitis tuberculous 21.66 13.27 16 86211 669 34870035
Pleural effusion 21.53 13.27 301 85926 81245 34789459
Accidental exposure to product 21.52 13.27 3 86224 12799 34857905
Frequent bowel movements 21.49 13.27 3 86224 12784 34857920
Speech disorder 21.49 13.27 19 86208 25667 34845037
Underdose 21.44 13.27 4 86223 13776 34856928
Necrosis 21.29 13.27 45 86182 5678 34865026
Full blood count decreased 21.22 13.27 9 86218 18079 34852625
Procedural nausea 21.16 13.27 8 86219 79 34870625
Palpitations 20.79 13.27 42 86185 39944 34830760
Choriocarcinoma 20.68 13.27 5 86222 7 34870697
Coronary artery thrombosis 20.55 13.27 26 86201 2133 34868571
Metastases to peritoneum 20.47 13.27 24 86203 1820 34868884
Soft tissue disorder 20.37 13.27 16 86211 734 34869970
Loss of consciousness 20.33 13.27 120 86107 82547 34788157
Morphoea 20.31 13.27 10 86217 196 34870508
Gene mutation 20.26 13.27 21 86206 1387 34869317
Blood glucose decreased 20.26 13.27 4 86223 13233 34857471
Burning sensation 20.26 13.27 10 86217 18384 34852320
Hypochloraemia 20.25 13.27 15 86212 630 34870074
Poisoning 20.24 13.27 3 86224 12223 34858481
Acquired tracheo-oesophageal fistula 20.24 13.27 8 86219 90 34870614
Hypogammaglobulinaemia 20.21 13.27 53 86174 7687 34863017
Hepatic steatosis 20.19 13.27 10 86217 18352 34852352
Erectile dysfunction 20.17 13.27 13 86214 20624 34850080
Injection site erythema 20.16 13.27 7 86220 15892 34854812
Pneumonia escherichia 20.10 13.27 13 86214 437 34870267
Eosinophilia 20.07 13.27 21 86206 26201 34844503
Metastases to skin 20.05 13.27 13 86214 439 34870265
Mitral valve incompetence 19.97 13.27 6 86221 14937 34855767
Metastases to bone 19.96 13.27 70 86157 11900 34858804
Gastrointestinal obstruction 19.88 13.27 17 86210 880 34869824
Hypoaesthesia 19.84 13.27 81 86146 61363 34809341
Polyneuropathy 19.78 13.27 81 86146 14815 34855889
Vascular injury 19.74 13.27 11 86216 280 34870424
Arteritis 19.74 13.27 12 86215 361 34870343
Candida pneumonia 19.71 13.27 13 86214 452 34870252
Necrosis ischaemic 19.71 13.27 11 86216 281 34870423
Adrenocortical carcinoma 19.71 13.27 6 86221 28 34870676
Metastases to meninges 19.70 13.27 21 86206 1433 34869271
Gastrointestinal ischaemia 19.68 13.27 10 86217 210 34870494
Neuroblastoma recurrent 19.65 13.27 9 86218 149 34870555
Pneumonia adenoviral 19.62 13.27 12 86215 365 34870339
Hallucination, auditory 19.55 13.27 3 86224 11914 34858790
Campylobacter test positive 19.53 13.27 6 86221 29 34870675
Obesity 19.48 13.27 4 86223 12874 34857830
Pneumothorax 19.48 13.27 96 86131 18996 34851708
Swelling face 19.44 13.27 17 86210 23088 34847616
Dementia 19.35 13.27 5 86222 13743 34856961
Tumour thrombosis 19.34 13.27 8 86219 102 34870602
Procedural vomiting 19.30 13.27 10 86217 219 34870485
Transitional cell carcinoma recurrent 19.25 13.27 5 86222 11 34870693
Peritoneal lesion 19.20 13.27 8 86219 104 34870600
Respiratory depression 19.19 13.27 8 86219 16237 34854467
Carotid artery dissection 19.17 13.27 9 86218 158 34870546
Product quality issue 19.16 13.27 9 86218 17026 34853678
Plasma cell leukaemia 19.13 13.27 17 86210 927 34869777
Delusion 18.96 13.27 4 86223 12631 34858073
Iliac artery occlusion 18.87 13.27 9 86218 164 34870540
Treatment noncompliance 18.83 13.27 25 86202 28075 34842629
Hepatic enzyme increased 18.70 13.27 43 86184 39037 34831667
Injection site swelling 18.69 13.27 3 86224 11524 34859180
Oesophageal pain 18.63 13.27 16 86211 833 34869871
Withdrawal syndrome 18.57 13.27 4 86223 12451 34858253
Traumatic lung injury 18.51 13.27 19 86208 1241 34869463
Migraine 18.51 13.27 10 86217 17468 34853236
Thrombocytosis 18.50 13.27 35 86192 4077 34866627
Fanconi syndrome 18.45 13.27 22 86205 1698 34869006
B-cell lymphoma refractory 18.39 13.27 9 86218 174 34870530
Laryngeal pain 18.38 13.27 28 86199 2736 34867968
Neutrophil count abnormal 18.26 13.27 23 86204 1879 34868825
Skin toxicity 18.24 13.27 38 86189 4746 34865958
Visceral venous thrombosis 18.14 13.27 5 86222 15 34870689
Movement disorder 18.13 13.27 4 86223 12244 34858460
Neoplasm 18.08 13.27 41 86186 5426 34865278
Mucosal toxicity 18.07 13.27 10 86217 251 34870453
Dry skin 17.91 13.27 31 86196 31256 34839448
Transformation to acute myeloid leukaemia 17.83 13.27 15 86212 759 34869945
Paranoia 17.74 13.27 4 86223 12064 34858640
Bladder cancer 17.70 13.27 9 86218 16269 34854435
Venous thrombosis 17.69 13.27 31 86196 3404 34867300
Failure to thrive 17.67 13.27 54 86173 8547 34862157
Urinary tract infection 17.66 13.27 128 86099 83953 34786751
Intestinal infarction 17.63 13.27 13 86214 542 34870162
Hypoalbuminaemia 17.62 13.27 68 86159 12106 34858598
Extremity necrosis 17.60 13.27 23 86204 1949 34868755
Gastrointestinal perforation 17.52 13.27 33 86194 3830 34866874
Cardiogenic shock 17.51 13.27 24 86203 26594 34844110
White blood cell disorder 17.50 13.27 21 86206 1632 34869072
Osteomyelitis 17.43 13.27 9 86218 16127 34854577
Chromaturia 17.39 13.27 7 86220 14513 34856191
Metastases to chest wall 17.34 13.27 9 86218 198 34870506
Trigeminal nerve paresis 17.27 13.27 4 86223 4 34870700
Joint stiffness 17.25 13.27 3 86224 10870 34859834
Hypophosphataemia 17.13 13.27 63 86164 10963 34859741
Blood creatinine 17.09 13.27 6 86221 47 34870657
Infected neoplasm 17.09 13.27 7 86220 87 34870617
Human chorionic gonadotropin increased 17.04 13.27 5 86222 20 34870684
Head injury 17.00 13.27 12 86215 18148 34852556
Dermatitis diaper 16.97 13.27 10 86217 284 34870420
Eye pain 16.95 13.27 6 86221 13456 34857248
Chemotherapeutic drug level increased 16.90 13.27 9 86218 209 34870495
Cell-mediated immune deficiency 16.87 13.27 6 86221 49 34870655
Laryngeal inflammation 16.85 13.27 5 86222 21 34870683
Haemorrhagic tumour necrosis 16.80 13.27 4 86223 5 34870699
Blister 16.72 13.27 19 86208 22839 34847865
Immune-mediated renal disorder 16.71 13.27 8 86219 147 34870557
Blood triglycerides increased 16.68 13.27 7 86220 14152 34856552
Small cell lung cancer 16.66 13.27 22 86205 1883 34868821
Dyspnoea 16.64 13.27 760 85467 376022 34494682
Gingivitis ulcerative 16.56 13.27 6 86221 52 34870652
Hypersomnia 16.55 13.27 5 86222 12402 34858302
Haemoptysis 16.53 13.27 145 86082 34861 34835843
Hyperglycaemic hyperosmolar nonketotic syndrome 16.49 13.27 18 86209 1262 34869442
Muscle rigidity 16.48 13.27 3 86224 10515 34860189
Amnesia 16.44 13.27 25 86202 26538 34844166
Dysstasia 16.11 13.27 5 86222 12190 34858514
Subdural haematoma 16.03 13.27 16 86211 20405 34850299
Dyspnoea exertional 15.97 13.27 54 86173 43225 34827479
Brachiocephalic vein thrombosis 15.96 13.27 7 86220 104 34870600
Myeloid leukaemia 15.95 13.27 11 86216 412 34870292
Drug clearance decreased 15.91 13.27 21 86206 1797 34868907
Basal cell carcinoma 15.90 13.27 15 86212 19643 34851061
Ureteric dilatation 15.88 13.27 8 86219 165 34870539
Premature baby 15.85 13.27 15 86212 19618 34851086
Urine sodium increased 15.81 13.27 6 86221 60 34870644
Testicular germ cell cancer metastatic 15.81 13.27 6 86221 60 34870644
Wound evisceration 15.78 13.27 7 86220 107 34870597
Cellulitis 15.75 13.27 72 86155 52879 34817825
Subcutaneous emphysema 15.75 13.27 17 86210 1177 34869527
Rectal haemorrhage 15.70 13.27 49 86178 40200 34830504
Ill-defined disorder 15.69 13.27 72 86155 13837 34856867
Ganglioneuroma 15.66 13.27 4 86223 8 34870696
Rib fracture 15.60 13.27 8 86219 14392 34856312
Aortitis 15.56 13.27 11 86216 429 34870275
Hip fracture 15.56 13.27 5 86222 11920 34858784
Gastrointestinal anastomotic leak 15.47 13.27 11 86216 433 34870271
Staphylococcus test positive 15.44 13.27 28 86199 3158 34867546
Lymphangiosis carcinomatosa 15.43 13.27 15 86212 917 34869787
Monocyte count decreased 15.38 13.27 17 86210 1209 34869495
Osteosarcoma metastatic 15.34 13.27 4 86223 9 34870695
Seizure 15.32 13.27 175 86052 104682 34766022
Recurrent cancer 15.31 13.27 18 86209 1369 34869335
Candida infection 15.26 13.27 85 86142 17630 34853074
Tooth disorder 15.23 13.27 4 86223 10878 34859826
Anaplastic lymphoma kinase gene mutation 15.11 13.27 7 86220 119 34870585
Evans syndrome 15.10 13.27 9 86218 261 34870443
Limb injury 15.08 13.27 5 86222 11684 34859020
Salivary gland cancer recurrent 15.02 13.27 3 86224 0 34870704
Pharyngeal stenosis 15.02 13.27 3 86224 0 34870704
Heart rate increased 15.02 13.27 61 86166 46282 34824422
Chronic hepatitis B 14.98 13.27 5 86222 33 34870671
Immune-mediated lung disease 14.89 13.27 19 86208 1572 34869132
Device issue 14.87 13.27 3 86224 9774 34860930
Laboratory test abnormal 14.86 13.27 17 86210 20374 34850330
Testicular cancer metastatic 14.83 13.27 6 86221 72 34870632
Blastic plasmacytoid dendritic cell neoplasia 14.76 13.27 6 86221 73 34870631
No adverse event 14.76 13.27 21 86206 22906 34847798
Agranulocytosis 14.73 13.27 105 86122 23716 34846988
Malassezia infection 14.73 13.27 5 86222 35 34870669
Myelitis transverse 14.63 13.27 16 86211 1124 34869580
Hypovolaemia 14.54 13.27 53 86174 9181 34861523
Pulmonary oedema 14.51 13.27 64 86163 47465 34823239
Metapneumovirus bronchiolitis 14.51 13.27 4 86223 12 34870692
Haemorrhoids 14.49 13.27 9 86218 14566 34856138
Dysphonia 14.48 13.27 22 86205 23361 34847343
Abdominal pain upper 14.45 13.27 110 86117 71380 34799324
Hyperlipidaemia 14.41 13.27 9 86218 14520 34856184
Benign prostatic hyperplasia 14.34 13.27 9 86218 14486 34856218
Thrombotic thrombocytopenic purpura 14.32 13.27 28 86199 3342 34867362
Hypercreatininaemia 14.28 13.27 11 86216 490 34870214
Cough 14.15 13.27 273 85954 149867 34720837
Haematoma 14.09 13.27 26 86201 25579 34845125
Heart rate irregular 14.08 13.27 11 86216 15796 34854908
Ventricular extrasystoles 14.04 13.27 6 86221 12002 34858702
Apparent mineralocorticoid excess 14.04 13.27 5 86222 41 34870663
Renal tubular necrosis 14.02 13.27 76 86151 15604 34855100
Subclavian vein thrombosis 13.99 13.27 14 86213 887 34869817
Nocturia 13.83 13.27 4 86223 10206 34860498
Dropped head syndrome 13.82 13.27 7 86220 146 34870558
Cerebrovascular accident 13.82 13.27 138 86089 84673 34786031
Cholangitis 13.79 13.27 50 86177 8639 34862065
Sarcoma 13.75 13.27 10 86217 408 34870296
Ventricular tachycardia 13.75 13.27 28 86199 26551 34844153
Therapeutic embolisation 13.67 13.27 9 86218 312 34870392
Torulopsis infection 13.63 13.27 4 86223 16 34870688
Escherichia bacteraemia 13.63 13.27 27 86200 3253 34867451
Penile vein thrombosis 13.63 13.27 4 86223 16 34870688
Malocclusion 13.63 13.27 6 86221 90 34870614
Discomfort 13.58 13.27 16 86211 18922 34851782
Red blood cell sedimentation rate increased 13.54 13.27 3 86224 9159 34861545
Chondrosarcoma 13.54 13.27 5 86222 46 34870658
Melanosis 13.44 13.27 4 86223 17 34870687
Focal nodular hyperplasia 13.40 13.27 7 86220 156 34870548
Systemic toxicity 13.35 13.27 5 86222 48 34870656
Immunosuppression 13.35 13.27 40 86187 6264 34864440
Lip swelling 13.32 13.27 12 86215 16068 34854636

FDA Adverse Event Reporting System (Geriatric)

MedDRA adverse event termLikelihood ratioLikelihood ratio thresholdPatients taking drug having adverse eventPatients taking drug not having adverse eventPatients not taking drug having adverse eventPatients not taking drug not having adverse event
Febrile neutropenia 2362.74 12.74 2333 124465 228666 79388924
Neutropenia 1941.01 12.74 2334 124464 285376 79332214
Disease progression 1406.73 12.74 1595 125203 182767 79434823
Thrombocytopenia 1369.03 12.74 1886 124912 263373 79354217
Malignant neoplasm progression 1256.39 12.74 1302 125496 134688 79482902
Mucosal inflammation 1155.74 12.74 959 125839 74621 79542969
Pancytopenia 898.26 12.74 1208 125590 164537 79453053
Bone marrow failure 836.65 12.74 675 126123 50432 79567158
Myelosuppression 834.37 12.74 612 126186 39684 79577906
Haematotoxicity 781.59 12.74 415 126383 15104 79602486
Anaemia 665.18 12.74 1875 124923 443140 79174450
Leukopenia 574.73 12.74 812 125986 115701 79501889
Acute myeloid leukaemia 539.68 12.74 424 126374 30461 79587129
Arthralgia 515.28 12.74 137 126661 571666 79045924
Dehydration 490.95 12.74 1163 125635 247024 79370566
Vomiting 454.64 12.74 2175 124623 663653 78953937
Second primary malignancy 450.14 12.74 282 126516 14068 79603522
Renal salt-wasting syndrome 416.94 12.74 115 126683 601 79616989
Off label use 394.06 12.74 2624 124174 904591 78712999
Neutrophil count decreased 392.78 12.74 606 126192 93353 79524237
Completed suicide 373.77 12.74 3 126795 245764 79371826
Neoplasm progression 369.25 12.74 433 126365 51249 79566341
Therapy partial responder 350.44 12.74 260 126538 17137 79600453
Ototoxicity 349.36 12.74 147 126651 3127 79614463
Neutropenic sepsis 345.44 12.74 310 126488 26754 79590836
Nausea 341.00 12.74 2640 124158 954556 78663034
Nephropathy toxic 334.60 12.74 270 126528 20149 79597441
Aortic thrombosis 330.70 12.74 118 126680 1577 79616013
Joint swelling 324.51 12.74 39 126759 288607 79328983
Fall 318.11 12.74 191 126607 487438 79130152
Myelodysplastic syndrome 295.25 12.74 299 126499 30002 79587588
Product dose omission issue 286.90 12.74 30 126768 247507 79370083
Rheumatoid arthritis 283.42 12.74 11 126787 208459 79409131
Acute kidney injury 280.38 12.74 1591 125207 517813 79099777
Hypomagnesaemia 280.01 12.74 359 126439 46552 79571038
Tumour lysis syndrome 266.36 12.74 254 126544 23685 79593905
Pulmonary embolism 258.00 12.74 726 126072 170928 79446662
Pain 251.85 12.74 460 126338 703342 78914248
Peripheral swelling 241.61 12.74 65 126733 269552 79348038
Arthropathy 238.53 12.74 10 126788 177101 79440489
Drug abuse 238.27 12.74 4 126794 162687 79454903
Headache 236.80 12.74 424 126374 653348 78964242
Pyrexia 233.04 12.74 1858 124940 676851 78940739
Platelet count decreased 232.12 12.74 759 126039 193905 79423685
Sepsis 230.48 12.74 943 125855 268485 79349105
Diffuse large B-cell lymphoma recurrent 230.29 12.74 119 126679 4088 79613502
Weight increased 223.30 12.74 81 126717 277305 79340285
Musculoskeletal stiffness 222.70 12.74 14 126784 174994 79442596
Metastases to central nervous system 217.76 12.74 192 126606 16183 79601407
Cardiotoxicity 215.84 12.74 169 126629 12070 79605520
Dysphagia 215.18 12.74 548 126250 121588 79496002
Nasopharyngitis 213.24 12.74 69 126729 253812 79363778
Hypokalaemia 206.45 12.74 599 126199 143441 79474149
Abdominal discomfort 203.87 12.74 72 126726 250655 79366935
Metastases to lung 202.60 12.74 193 126605 17970 79599620
Deafness 200.22 12.74 205 126593 20832 79596758
Decreased appetite 193.06 12.74 1062 125736 341356 79276234
Drug hypersensitivity 189.24 12.74 121 126677 298795 79318795
Septic shock 188.96 12.74 524 126274 122277 79495313
Hyponatraemia 188.72 12.74 667 126131 177181 79440409
Therapeutic product effect decreased 186.89 12.74 21 126777 163842 79453748
White blood cell count decreased 186.11 12.74 690 126108 187598 79429992
Posterior reversible encephalopathy syndrome 185.68 12.74 219 126579 26062 79591528
Pain in extremity 185.12 12.74 184 126614 364354 79253236
Renal impairment 184.25 12.74 611 126187 157172 79460418
Anastomotic leak 177.46 12.74 66 126732 999 79616591
Oesophagitis 174.25 12.74 204 126594 24085 79593505
Systemic lupus erythematosus 173.28 12.74 4 126794 121145 79496445
Swelling 168.17 12.74 67 126731 216644 79400946
Neuropathy peripheral 165.69 12.74 548 126250 140757 79476833
Condition aggravated 162.99 12.74 346 126452 500778 79116812
Renal failure 162.79 12.74 692 126106 200276 79417314
Product use in unapproved indication 156.38 12.74 799 125999 249560 79368030
Stomatitis 155.30 12.74 550 126248 146207 79471383
Drug resistance 153.96 12.74 256 126542 41957 79575633
Overdose 152.98 12.74 51 126747 184155 79433435
Asthma 152.33 12.74 18 126780 135077 79482513
Insomnia 151.41 12.74 102 126696 245068 79372522
Glossodynia 149.41 12.74 3 126795 103334 79514256
Pruritus 148.93 12.74 249 126549 394399 79223191
Contraindicated product administered 146.79 12.74 35 126763 157503 79460087
Radiation skin injury 145.07 12.74 62 126736 1372 79616218
Injection site pain 144.68 12.74 18 126780 129820 79487770
Contusion 140.71 12.74 32 126766 148744 79468846
Wound 140.04 12.74 12 126786 116167 79501423
Pemphigus 139.72 12.74 4 126794 99578 79518012
Metastases to liver 137.43 12.74 196 126602 28118 79589472
Muscle spasms 137.22 12.74 53 126745 174677 79442913
Tinnitus 137.11 12.74 250 126548 44083 79573507
Oesophageal fistula 136.17 12.74 44 126754 425 79617165
Arthritis 135.42 12.74 13 126785 114867 79502723
Inappropriate antidiuretic hormone secretion 134.91 12.74 187 126611 26126 79591464
Diffuse large B-cell lymphoma refractory 131.95 12.74 58 126740 1377 79616213
Disease recurrence 131.71 12.74 245 126553 43864 79573726
Teratoma 131.05 12.74 34 126764 134 79617456
Febrile bone marrow aplasia 129.60 12.74 130 126668 12890 79604700
Sinusitis 129.44 12.74 75 126723 195426 79422164
Hypocalcaemia 127.98 12.74 260 126538 49664 79567926
Intentional product misuse 126.04 12.74 6 126792 95159 79522431
Peripheral artery thrombosis 125.99 12.74 75 126723 3408 79614182
Gastrointestinal toxicity 123.96 12.74 103 126695 8006 79609584
Depression 122.44 12.74 99 126699 216691 79400899
Deep vein thrombosis 119.28 12.74 443 126355 120476 79497114
Metastases to lymph nodes 118.85 12.74 112 126686 10285 79607305
Mobility decreased 118.12 12.74 25 126773 122150 79495440
Hypophagia 117.16 12.74 237 126561 45130 79572460
Neurotoxicity 114.31 12.74 194 126604 32324 79585266
Anxiety 113.29 12.74 137 126661 248375 79369215
Blister 112.37 12.74 26 126772 119450 79498140
Aorto-oesophageal fistula 111.81 12.74 26 126772 56 79617534
Osteoarthritis 110.98 12.74 7 126791 87302 79530288
Gastric perforation 108.49 12.74 72 126726 3965 79613625
Migraine 108.34 12.74 8 126790 87485 79530105
Ovarian germ cell teratoma 107.78 12.74 25 126773 53 79617537
Drug intolerance 106.80 12.74 159 126639 263960 79353630
Wheezing 106.57 12.74 27 126771 116637 79500953
Urticaria 106.55 12.74 83 126715 185118 79432472
Hepatic enzyme increased 106.12 12.74 81 126717 182529 79435061
Psoriasis 105.95 12.74 10 126788 89577 79528013
Pneumonitis 104.96 12.74 271 126527 60589 79557001
Palmar-plantar erythrodysaesthesia syndrome 102.64 12.74 187 126611 32947 79584643
Peripheral ischaemia 102.64 12.74 99 126699 9358 79608232
Renal tubular disorder 102.52 12.74 84 126714 6402 79611188
Dizziness 102.24 12.74 460 126338 525981 79091609
Discomfort 102.16 12.74 36 126762 125581 79492009
Venoocclusive liver disease 101.80 12.74 109 126689 11662 79605928
Electrolyte imbalance 101.70 12.74 179 126619 30702 79586888
Gait disturbance 101.53 12.74 108 126690 207398 79410192
Rash 101.51 12.74 524 126274 577834 79039756
Leukoencephalopathy 101.50 12.74 91 126707 7838 79609752
Arterial thrombosis 100.45 12.74 59 126739 2615 79614975
Hiccups 97.72 12.74 99 126699 9932 79607658
Suicidal ideation 97.39 12.74 6 126792 76334 79541256
Blood pressure increased 96.87 12.74 116 126682 211244 79406346
Bacteraemia 93.87 12.74 179 126619 32645 79584945
Stress 93.85 12.74 9 126789 79603 79537987
Hospitalisation 93.76 12.74 18 126780 94218 79523372
Radiation pneumonitis 93.45 12.74 65 126733 3868 79613722
Osteoradionecrosis 92.83 12.74 24 126774 93 79617497
Odynophagia 91.18 12.74 101 126697 11226 79606364
Dermatitis 91.08 12.74 139 126659 21182 79596408
Injury 90.72 12.74 9 126789 77487 79540103
Nasal congestion 89.33 12.74 9 126789 76543 79541047
Malignant transformation 89.16 12.74 42 126756 1176 79616414
Fibromyalgia 88.76 12.74 3 126795 64337 79553253
Feeling abnormal 88.25 12.74 74 126724 159125 79458465
Loss of personal independence in daily activities 87.62 12.74 27 126771 102553 79515037
Inappropriate schedule of product administration 87.38 12.74 52 126746 133576 79484014
Myalgia 87.09 12.74 100 126698 185541 79432049
Bronchitis 86.62 12.74 50 126748 130594 79486996
Suicide attempt 86.52 12.74 14 126784 82918 79534672
Infusion related reaction 86.07 12.74 146 126652 230091 79387499
Hypoacusis 85.70 12.74 164 126634 29986 79587604
Drug interaction 84.68 12.74 356 126442 414827 79202763
Colitis 82.05 12.74 280 126518 73027 79544563
Blood creatinine increased 81.93 12.74 473 126325 154584 79463006
Blood cholesterol increased 81.19 12.74 17 126781 83703 79533887
Teratoma benign 81.04 12.74 20 126778 61 79617529
Somnolence 80.92 12.74 161 126637 238820 79378770
Urogenital fistula 80.02 12.74 23 126775 143 79617447
Large intestine perforation 79.93 12.74 107 126691 14460 79603130
Acute respiratory distress syndrome 79.90 12.74 200 126598 43867 79573723
Blood lactate dehydrogenase increased 79.84 12.74 186 126612 38984 79578606
Recall phenomenon 79.54 12.74 38 126760 1099 79616491
Osteosarcoma 79.45 12.74 28 126770 360 79617230
Balance disorder 79.24 12.74 29 126769 98828 79518762
Drug reaction with eosinophilia and systemic symptoms 79.18 12.74 6 126792 64238 79553352
Injection site erythema 77.66 12.74 15 126783 78182 79539408
Radiation oesophagitis 76.99 12.74 32 126766 659 79616931
Metastasis 76.51 12.74 73 126725 6807 79610783
Respiratory failure 75.74 12.74 520 126278 180391 79437199
Metastases to skin 75.04 12.74 42 126756 1697 79615893
Thrombotic microangiopathy 74.45 12.74 123 126675 20046 79597544
Influenza 73.37 12.74 59 126739 129547 79488043
Blood pressure fluctuation 73.12 12.74 10 126788 67135 79550455
Bicytopenia 72.80 12.74 60 126738 4610 79612980
Cystitis haemorrhagic 72.48 12.74 81 126717 9091 79608499
Enteritis 72.31 12.74 102 126696 14481 79603109
Deafness bilateral 71.19 12.74 44 126754 2141 79615449
Exposure during pregnancy 70.99 12.74 36 126762 101096 79516494
Pleural effusion 70.88 12.74 434 126364 144828 79472762
Cytomegalovirus oesophagitis 70.80 12.74 31 126767 729 79616861
Rhabdomyolysis 70.48 12.74 38 126760 103093 79514497
Portal venous gas 70.37 12.74 26 126772 386 79617204
Neutropenic colitis 70.11 12.74 64 126734 5643 79611947
Wrong technique in product usage process 69.61 12.74 16 126782 73859 79543731
Deafness neurosensory 68.88 12.74 69 126729 6829 79610761
Memory impairment 68.23 12.74 47 126751 111687 79505903
Oesophageal stenosis 68 12.74 56 126742 4298 79613292
Chloroma 67.19 12.74 30 126768 740 79616850
Metastases to bone 67.14 12.74 131 126667 24296 79593294
Cytopenia 66.92 12.74 118 126680 20265 79597325
Pulmonary vascular disorder 66.76 12.74 33 126765 1030 79616560
Heart rate decreased 66.71 12.74 15 126783 70301 79547289
Influenza like illness 66.64 12.74 16 126782 71691 79545899
Hepatitis B 66.56 12.74 74 126724 8258 79609332
Oesophagobronchial fistula 66.19 12.74 22 126776 234 79617356
Pericarditis 66.15 12.74 42 126756 104194 79513396
Maternal exposure during pregnancy 65.72 12.74 72 126726 136466 79481124
Bronchial fistula 65.34 12.74 21 126777 199 79617391
Aplasia 65.15 12.74 71 126727 7749 79609841
Radiation injury 64.59 12.74 30 126768 813 79616777
Malaise 64.01 12.74 486 126312 489383 79128207
B-cell lymphoma recurrent 62.67 12.74 31 126767 969 79616621
Renal tubular necrosis 62.50 12.74 129 126669 24910 79592680
Interstitial lung disease 62.43 12.74 348 126450 112252 79505338
Embolism 62.34 12.74 93 126705 13889 79603701
Cardiac failure congestive 62.25 12.74 81 126717 142321 79475269
Adverse drug reaction 61.33 12.74 15 126783 66377 79551213
Cardiomyopathy 61.25 12.74 139 126659 28635 79588955
Diarrhoea 61.16 12.74 1831 124967 878658 78738932
Duodenal ulcer perforation 61.08 12.74 15 126783 66196 79551394
Polyneuropathy 60.96 12.74 125 126673 24026 79593564
Sleep disorder 60.88 12.74 30 126768 85647 79531943
Acquired gene mutation 60.43 12.74 40 126758 2193 79615397
Cataract 59.44 12.74 13 126785 62107 79555483
Injection site swelling 59.24 12.74 4 126794 47128 79570462
Osteoporosis 59.06 12.74 8 126790 54104 79563486
Bacterial translocation 58.43 12.74 26 126772 636 79616954
Vision blurred 57.73 12.74 50 126748 105848 79511742
Red blood cell sedimentation rate increased 57.45 12.74 4 126794 45938 79571652
Gastrooesophageal reflux disease 57.09 12.74 49 126749 104197 79513393
Salivary gland cancer 57.04 12.74 23 126775 437 79617153
Osteosarcoma metastatic 56.90 12.74 14 126784 42 79617548
Drug clearance decreased 56.63 12.74 45 126753 3282 79614308
Electrocardiogram QT prolonged 56.56 12.74 37 126761 90349 79527241
Hypoaesthesia 56.36 12.74 126 126672 179226 79438364
Pulmonary arteriopathy 56.29 12.74 16 126782 95 79617495
Atypical haemolytic uraemic syndrome 55.93 12.74 29 126769 1003 79616587
Metastases to breast 55.93 12.74 20 126778 269 79617321
Tumour necrosis 55.85 12.74 36 126762 1886 79615704
General physical health deterioration 55.35 12.74 675 126123 274563 79343027
Disseminated intravascular coagulation 55.12 12.74 153 126645 35689 79581901
Sedation 53.60 12.74 9 126789 51886 79565704
Serotonin syndrome 53.31 12.74 5 126793 45022 79572568
Vena cava thrombosis 53.27 12.74 41 126757 2854 79614736
Hypoglycaemia 52.95 12.74 50 126748 101544 79516046
Splenic infarction 52.83 12.74 45 126753 3619 79613971
Ameloblastoma 52.78 12.74 15 126783 89 79617501
Peritonitis 52.68 12.74 129 126669 27907 79589683
Tumour haemorrhage 51.94 12.74 47 126751 4097 79613493
Renal infarct 51.47 12.74 39 126759 2652 79614938
Incorrect dose administered 51.25 12.74 29 126769 76601 79540989
Mantle cell lymphoma recurrent 50.97 12.74 23 126775 582 79617008
Arteriospasm coronary 50.83 12.74 58 126740 6658 79610932
Cerebral infarction 50.69 12.74 174 126624 45502 79572088
Empyema 50.67 12.74 47 126751 4229 79613361
Performance status decreased 50.05 12.74 55 126743 6058 79611532
Fatigue 49.93 12.74 1113 125685 928614 78688976
Anastomotic complication 49.80 12.74 21 126777 449 79617141
Back pain 49.69 12.74 282 126516 303898 79313692
Lymphopenia 49.55 12.74 133 126665 30424 79587166
Neoplasm recurrence 49.32 12.74 46 126752 4168 79613422
Road traffic accident 48.75 12.74 6 126792 43658 79573932
Lower respiratory tract infection 48.21 12.74 82 126716 129138 79488452
Gastrointestinal perforation 48.15 12.74 54 126744 6083 79611507
Hypophosphataemia 47.84 12.74 101 126697 19812 79597778
Tremor 47.53 12.74 127 126671 169956 79447634
Lymphadenopathy 47.48 12.74 189 126609 53058 79564532
Hallucination 47.33 12.74 40 126758 85705 79531885
Fluid retention 47.29 12.74 26 126772 69783 79547807
Blood pressure systolic increased 46.77 12.74 24 126774 66962 79550628
Pulmonary toxicity 46.65 12.74 78 126720 12836 79604754
Heart rate increased 46.53 12.74 75 126723 120649 79496941
Cerebral venous thrombosis 46.36 12.74 37 126761 2716 79614874
Cardiac disorder 45.26 12.74 24 126774 65733 79551857
Tumour perforation 45.24 12.74 19 126779 402 79617188
Confusional state 44.61 12.74 309 126489 317688 79299902
Cholangitis 44.60 12.74 76 126722 12700 79604890
Hypersensitivity 44.53 12.74 240 126558 261999 79355591
Gait inability 44.39 12.74 19 126779 58898 79558692
Progressive multifocal leukoencephalopathy 44.38 12.74 100 126698 20500 79597090
Burning sensation 44.03 12.74 19 126779 58613 79558977
Blood stem cell transplant failure 44.00 12.74 20 126778 515 79617075
Palpitations 43.95 12.74 84 126714 126526 79491064
Product prescribing error 43.65 12.74 9 126789 44804 79572786
Blood sodium decreased 43.51 12.74 134 126664 33121 79584469
Drug withdrawal syndrome 43.48 12.74 3 126795 34715 79582875
Embolism arterial 43.05 12.74 28 126770 1490 79616100
Pneumatosis intestinalis 43.02 12.74 52 126746 6345 79611245
Blood creatine phosphokinase increased 42.80 12.74 26 126772 66064 79551526
Oedema peripheral 42.77 12.74 231 126567 252057 79365533
Aggression 42.46 12.74 14 126784 50944 79566646
Impaired healing 42.42 12.74 46 126752 87609 79529981
Injection site reaction 42.35 12.74 17 126781 54768 79562822
Extremity necrosis 41.89 12.74 37 126761 3124 79614466
Immune-mediated hepatic disorder 41.80 12.74 28 126770 1566 79616024
Hydronephrosis 41.32 12.74 88 126710 17366 79600224
Intestinal ischaemia 41.23 12.74 75 126723 13195 79604395
Chronic obstructive pulmonary disease 41.14 12.74 45 126753 85374 79532216
Fanconi syndrome 41.02 12.74 35 126763 2821 79614769
Necrosis 40.70 12.74 62 126736 9431 79608159
Metastases to peritoneum 40.50 12.74 42 126756 4330 79613260
Hypoalbuminaemia 40.02 12.74 98 126700 21199 79596391
Localised infection 39.97 12.74 6 126792 37569 79580021
Lactic acidosis 39.85 12.74 32 126766 70327 79547263
Radiation mucositis 39.80 12.74 15 126783 236 79617354
Dermatitis acneiform 39.68 12.74 63 126735 9930 79607660
Peripheral sensory neuropathy 39.66 12.74 73 126725 12960 79604630
Cerebral ischaemia 39.62 12.74 67 126731 11128 79606462
Type 2 diabetes mellitus 39.09 12.74 21 126777 57101 79560489
Angioedema 38.95 12.74 38 126760 75997 79541593
Nervousness 38.80 12.74 4 126794 33411 79584179
Small cell lung cancer 38.75 12.74 34 126764 2846 79614744
Sciatica 38.51 12.74 4 126794 33218 79584372
Haemophagocytic lymphohistiocytosis 38.42 12.74 98 126700 21739 79595851
Adrenocortical carcinoma 38.32 12.74 11 126787 68 79617522
Gastrointestinal fungal infection 38.21 12.74 18 126780 504 79617086
Joint stiffness 38.15 12.74 9 126789 40821 79576769
Osteosarcoma recurrent 38.04 12.74 10 126788 42 79617548
Blindness cortical 37.66 12.74 22 126776 965 79616625
Unevaluable event 37.22 12.74 21 126777 55564 79562026
Refeeding syndrome 37.03 12.74 11 126787 78 79617512
Pneumothorax 36.93 12.74 114 126684 28209 79589381
Coronary artery thrombosis 36.54 12.74 34 126764 3072 79614518
Metastases to adrenals 36.42 12.74 24 126774 1306 79616284
Throat irritation 36.38 12.74 10 126788 40936 79576654
Nasal abscess 36.01 12.74 13 126785 180 79617410
Prescribed underdose 35.69 12.74 3 126795 29511 79588079
Abortion spontaneous 35.68 12.74 3 126795 29504 79588086
Gastric disorder 35.48 12.74 8 126790 37425 79580165
Myasthenia gravis crisis 35.25 12.74 22 126776 1089 79616501
Oesophageal perforation 35.09 12.74 25 126773 1546 79616044
Product use issue 35.07 12.74 193 126605 209629 79407961
Upper respiratory tract infection 34.79 12.74 57 126741 91111 79526479
Extravasation 34.69 12.74 36 126762 3714 79613876
Lip swelling 34.51 12.74 11 126787 40900 79576690
Plasma cell leukaemia 34.42 12.74 26 126772 1760 79615830
Obesity 34.32 12.74 7 126791 35118 79582472
Gastrointestinal anastomotic leak 34.32 12.74 17 126781 533 79617057
Blood glucose increased 34.32 12.74 83 126715 114892 79502698
Neoplasm 34.19 12.74 56 126742 9060 79608530
Large intestinal ulcer perforation 34.15 12.74 10 126788 67 79617523
Metastases to meninges 34.09 12.74 35 126763 3566 79614024
Cytokine release syndrome 33.90 12.74 130 126668 35868 79581722
Neurosensory hypoacusis 33.79 12.74 13 126785 217 79617373
Eye pain 33.73 12.74 9 126789 37569 79580021
Musculoskeletal pain 33.72 12.74 70 126728 102284 79515306
Cholelithiasis 33.71 12.74 21 126777 52643 79564947
Candida infection 33.56 12.74 135 126663 38079 79579511
Refractory cancer 33.46 12.74 13 126785 223 79617367
Ear infection 33.36 12.74 7 126791 34425 79583165
Accidental exposure to product 33.32 12.74 5 126793 31317 79586273
Hyperhidrosis 33.28 12.74 126 126672 151366 79466224
Ureteric rupture 33.28 12.74 7 126791 7 79617583
Injection site haemorrhage 33.24 12.74 3 126795 27867 79589723
Coronary artery disease 33.21 12.74 33 126765 65441 79552149
Muscular weakness 33.20 12.74 137 126661 160592 79456998
Frequent bowel movements 33.12 12.74 4 126794 29535 79588055
Labelled drug-drug interaction medication error 32.92 12.74 3 126795 27647 79589943
BK virus infection 32.91 12.74 54 126744 8750 79608840
Melanoderma 32.69 12.74 15 126783 395 79617195
Wernicke's encephalopathy 32.51 12.74 8 126790 24 79617566
Acoustic stimulation tests abnormal 32.51 12.74 8 126790 24 79617566
Skin toxicity 32.44 12.74 52 126746 8262 79609328
Thrombophlebitis 32.43 12.74 45 126753 6290 79611300
Cervix neoplasm 32.30 12.74 12 126786 181 79617409
COVID-19 32.20 12.74 135 126663 157539 79460051
Hepatitis B reactivation 32.19 12.74 44 126754 6064 79611526
Product administration error 31.85 12.74 6 126792 31840 79585750
Blood pressure diastolic decreased 31.74 12.74 5 126793 30211 79587379
Pregnancy 31.73 12.74 3 126795 26848 79590742
Flagellate dermatitis 31.63 12.74 13 126785 260 79617330
Basal cell carcinoma 31.62 12.74 10 126788 37365 79580225
Plasmacytoma 31.60 12.74 37 126761 4366 79613224
Underdose 31.59 12.74 7 126791 33144 79584446
Intestinal perforation 31.49 12.74 79 126719 17347 79600243
Limb discomfort 31.17 12.74 7 126791 32843 79584747
Mesenteric abscess 31.17 12.74 11 126787 142 79617448
Limb injury 30.76 12.74 5 126793 29523 79588067
Hyperammonaemic encephalopathy 30.75 12.74 38 126760 4744 79612846
Intentional product use issue 30.59 12.74 131 126667 151981 79465609
Prescribed overdose 30.54 12.74 11 126787 37872 79579718
Rhinorrhoea 30.51 12.74 46 126752 76028 79541562
Sleep apnoea syndrome 30.43 12.74 10 126788 36468 79581122
Chemical peritonitis 30.40 12.74 13 126785 288 79617302
Myoclonus 30.40 12.74 4 126794 27656 79589934
Folliculitis 30.36 12.74 26 126772 55354 79562236
Hepatic steatosis 30.35 12.74 11 126787 37727 79579863
Tumour thrombosis 30.17 12.74 11 126787 157 79617433
Lymphangiosis carcinomatosa 30.13 12.74 26 126772 2128 79615462
Visceral venous thrombosis 30.13 12.74 7 126791 15 79617575
Emotional distress 29.93 12.74 13 126785 39956 79577634
Toxicity to various agents 29.81 12.74 481 126317 421059 79196531
Blood HIV RNA increased 29.81 12.74 24 126774 1784 79615806
Swelling face 29.60 12.74 42 126756 71170 79546420
Nephritis bacterial 29.46 12.74 8 126790 39 79617551
Medulloblastoma recurrent 29.46 12.74 10 126788 114 79617476
Lymphoma 29.32 12.74 77 126721 17383 79600207
Urinary tract infection 29.24 12.74 287 126511 274225 79343365
Hepatic candidiasis 28.82 12.74 9 126789 77 79617513
Superior mesenteric artery syndrome 28.73 12.74 11 126787 181 79617409
International normalised ratio increased 28.71 12.74 57 126741 84664 79532926
Diaphragm muscle weakness 28.68 12.74 11 126787 182 79617408
Swollen tongue 28.62 12.74 16 126782 42554 79575036
Melanosis 28.51 12.74 8 126790 45 79617545
Dyskinesia 28.45 12.74 18 126780 44755 79572835
Amnesia 28.45 12.74 35 126763 63022 79554568
Irritability 28.34 12.74 15 126783 41129 79576461
Femur fracture 28.27 12.74 13 126785 38639 79578951
Abdominal pain upper 28.25 12.74 224 126574 223595 79393995
Medication error 28.02 12.74 41 126757 68601 79548989
Pancreatitis 27.95 12.74 41 126757 68534 79549056
EGFR gene mutation 27.94 12.74 14 126784 450 79617140
Malnutrition 27.89 12.74 89 126709 22413 79595177
Nightmare 27.81 12.74 4 126794 25857 79591733
Traumatic lung injury 27.79 12.74 26 126772 2365 79615225
Myocardial infarction 27.77 12.74 175 126623 183954 79433636
Cerebellar haemangioma 27.75 12.74 9 126789 88 79617502
Haemoptysis 27.72 12.74 168 126630 55831 79561759
Dry eye 27.68 12.74 12 126786 36919 79580671
Neutrophil count abnormal 27.62 12.74 31 126767 3495 79614095
Metastatic neoplasm 27.61 12.74 37 126761 5005 79612585
Agranulocytosis 27.54 12.74 143 126655 44887 79572703
Enterocolitis 27.50 12.74 67 126731 14445 79603145
Device issue 27.34 12.74 5 126793 27103 79590487
Stress cardiomyopathy 27.25 12.74 57 126741 11109 79606481
Tracheo-oesophageal fistula 27.14 12.74 15 126783 591 79616999
Myeloid leukaemia 27.08 12.74 16 126782 717 79616873
Herpes simplex encephalitis 27.02 12.74 16 126782 720 79616870
Intervertebral disc protrusion 26.98 12.74 3 126795 23618 79593972
Aortitis 26.98 12.74 21 126777 1486 79616104
Dyspnoea 26.97 12.74 1102 125696 855923 78761667
Poisoning 26.96 12.74 4 126794 25268 79592322
Clostridium bacteraemia 26.93 12.74 13 126785 385 79617205
Therapy cessation 26.91 12.74 13 126785 37549 79580041
Nephrolithiasis 26.87 12.74 27 126771 53264 79564326
Testicular malignant teratoma 26.81 12.74 6 126792 10 79617580
Right ventricular failure 26.80 12.74 3 126795 23494 79594096
Lymphadenopathy mediastinal 26.78 12.74 34 126764 4362 79613228
Haemoglobin decreased 26.73 12.74 499 126299 221620 79395970
Tracheal stenosis 26.71 12.74 13 126785 392 79617198
Hepatic cirrhosis 26.71 12.74 11 126787 34895 79582695
Agitation 26.69 12.74 76 126722 99639 79517951
Necrotising colitis 26.63 12.74 18 126780 1022 79616568
Liver abscess 26.61 12.74 40 126758 6014 79611576
Hip fracture 26.43 12.74 8 126790 30753 79586837
Rib fracture 26.43 12.74 6 126792 27941 79589649
Gout 26.21 12.74 4 126794 24745 79592845
Blood glucose decreased 26.11 12.74 5 126793 26229 79591361
Device related infection 26.11 12.74 116 126682 34178 79583412
Failure to thrive 26.08 12.74 58 126740 11786 79605804
Papillary thyroid cancer 26.06 12.74 26 126772 2560 79615030
Erythropenia 25.94 12.74 13 126785 418 79617172
Alpha 1 foetoprotein increased 25.64 12.74 16 126782 792 79616798
Acne 25.39 12.74 6 126792 27184 79590406
Ascites 25.24 12.74 206 126592 75356 79542234
Cystitis 25.15 12.74 28 126770 52704 79564886
Multiple sclerosis 25.03 12.74 3 126795 22279 79595311
Acute promyelocytic leukaemia 25.02 12.74 20 126778 1471 79616119
Ileus 24.96 12.74 95 126703 26116 79591474
Varicella zoster virus infection 24.95 12.74 33 126765 4408 79613182
Blood magnesium decreased 24.91 12.74 70 126728 16442 79601148
Cerebral venous sinus thrombosis 24.89 12.74 24 126774 2267 79615323
Pain in jaw 24.89 12.74 22 126776 46129 79571461
Encephalopathy 24.86 12.74 188 126610 67209 79550381
Hepatic function abnormal 24.80 12.74 200 126598 72907 79544683
Diabetes mellitus 24.67 12.74 55 126743 78335 79539255
Joint range of motion decreased 24.65 12.74 11 126787 33271 79584319
Wound evisceration 24.65 12.74 9 126789 129 79617461
Klebsiella test positive 24.51 12.74 21 126777 1702 79615888
Sopor 24.31 12.74 11 126787 32999 79584591
Granulocyte-colony stimulating factor level increased 24.30 12.74 5 126793 4 79617586
Metastases to pleura 24.30 12.74 20 126778 1534 79616056
Dysstasia 24.24 12.74 7 126791 27739 79589851
Multiple organ dysfunction syndrome 24.17 12.74 295 126503 119951 79497639
Product quality issue 23.93 12.74 12 126786 33928 79583662
Crying 23.79 12.74 4 126794 23039 79594551
Hypogammaglobulinaemia 23.70 12.74 59 126739 12892 79604698
Asthenia 23.70 12.74 1017 125781 510672 79106918
Accidental overdose 23.69 12.74 17 126781 39564 79578026
Ovarian vein thrombosis 23.64 12.74 7 126791 49 79617541
Movement disorder 23.59 12.74 7 126791 27252 79590338
Adverse event 23.58 12.74 37 126761 60177 79557413
Subclavian vein thrombosis 23.48 12.74 24 126774 2433 79615157
Gene mutation 23.45 12.74 25 126773 2661 79614929
Fanconi syndrome acquired 23.39 12.74 25 126773 2669 79614921
Plasma cell myeloma recurrent 23.36 12.74 34 126764 4967 79612623
Iron deficiency anaemia 23.32 12.74 6 126792 25666 79591924
Sinus polyp 23.23 12.74 13 126785 525 79617065
Stem cell transplant 23.12 12.74 29 126769 3675 79613915
Prostate cancer 23.10 12.74 12 126786 33256 79584334
Immune-mediated lung disease 23.04 12.74 23 126775 2267 79615323
Transient ischaemic attack 22.99 12.74 30 126768 52665 79564925
Hallucination, auditory 22.72 12.74 3 126795 20690 79596900
Immune-mediated myocarditis 22.70 12.74 17 126781 1136 79616454
Retroperitoneal neoplasm metastatic 22.67 12.74 6 126792 26 79617564
Haematoma 22.48 12.74 30 126768 52165 79565425
Bradycardia 22.47 12.74 125 126673 135432 79482158
Clostridium colitis 22.31 12.74 25 126773 2814 79614776
Tooth disorder 22.22 12.74 7 126791 26226 79591364
Cannabinoid hyperemesis syndrome 22.20 12.74 7 126791 62 79617528
Liver function test abnormal 22.17 12.74 43 126755 64432 79553158
Streptococcal bacteraemia 22.14 12.74 28 126770 3578 79614012
Immune-mediated dermatitis 22.11 12.74 13 126785 577 79617013
Pharyngeal inflammation 22.11 12.74 16 126782 1014 79616576
Retinopathy 21.99 12.74 29 126769 3862 79613728
Gastrointestinal necrosis 21.98 12.74 35 126763 5530 79612060
Staphylococcus test positive 21.90 12.74 38 126760 6443 79611147
Granulocyte count decreased 21.67 12.74 20 126778 1788 79615802
Recurrent cancer 21.65 12.74 24 126774 2669 79614921
Chromaturia 21.58 12.74 7 126791 25739 79591851
Lung cancer metastatic 21.57 12.74 28 126770 3671 79613919
Muscle spasticity 21.57 12.74 4 126794 21471 79596119
Mood swings 21.55 12.74 3 126795 19877 79597713
Chest discomfort 21.43 12.74 130 126668 137914 79479676
Transitional cell carcinoma recurrent 21.43 12.74 5 126793 11 79617579
Gingivitis ulcerative 21.39 12.74 10 126788 275 79617315
Unmasking of previously unidentified disease 21.32 12.74 21 126777 2036 79615554
Arteritis 21.28 12.74 15 126783 912 79616678
Axillary vein thrombosis 21.23 12.74 13 126785 622 79616968
Renal tubular dysfunction 21.22 12.74 14 126784 763 79616827
Extrapyramidal disorder 21.19 12.74 5 126793 22674 79594916
Staphylococcal infection 21.16 12.74 162 126636 58133 79559457
Angina pectoris 21.02 12.74 31 126767 51701 79565889
Aortic embolus 21.01 12.74 7 126791 75 79617515
Heart rate irregular 20.96 12.74 13 126785 32666 79584924
Acquired tracheo-oesophageal fistula 20.93 12.74 8 126790 131 79617459
Amputation stump pain 20.92 12.74 6 126792 37 79617553
Sinus disorder 20.89 12.74 5 126793 22459 79595131
Metastases to abdominal cavity 20.70 12.74 13 126785 651 79616939
Hypercalcaemia of malignancy 20.69 12.74 11 126787 401 79617189
Purulent pericarditis 20.61 12.74 7 126791 80 79617510
Bone marrow disorder 20.59 12.74 26 126772 3317 79614273
Blood culture positive 20.53 12.74 43 126755 8386 79609204
Clonal haematopoiesis 20.52 12.74 6 126792 40 79617550
Eye irritation 20.46 12.74 4 126794 20677 79596913
Fistula of small intestine 20.43 12.74 14 126784 813 79616777
Enterocolitis infectious 20.41 12.74 24 126774 2845 79614745
Myelitis transverse 20.41 12.74 20 126778 1927 79615663
Jaw operation 20.40 12.74 14 126784 815 79616775
Candida pneumonia 20.39 12.74 13 126785 668 79616922
Sarcomatoid carcinoma 20.39 12.74 6 126792 41 79617549
Dysphonia 20.38 12.74 37 126761 56835 79560755
Eye pruritus 20.31 12.74 4 126794 20566 79597024
Embryonal rhabdomyosarcoma 20.26 12.74 6 126792 42 79617548
Liver function test increased 20.22 12.74 20 126778 39753 79577837
Pneumonia 20.12 12.74 1261 125537 658985 78958605
Disturbance in attention 20.10 12.74 31 126767 50770 79566820
Iliac artery occlusion 20.09 12.74 10 126788 317 79617273
Abnormal behaviour 20.08 12.74 17 126781 36404 79581186
Gastrointestinal obstruction 20.08 12.74 19 126779 1753 79615837
Uterine atrophy 20.08 12.74 5 126793 16 79617574
Adrenal insufficiency 19.93 12.74 94 126704 28393 79589197
Apparent mineralocorticoid excess 19.91 12.74 6 126792 45 79617545
Viral load increased 19.89 12.74 24 126774 2924 79614666
Subcutaneous emphysema 19.88 12.74 19 126779 1775 79615815
Meningitis tuberculous 19.87 12.74 16 126782 1189 79616401
Hypersomnia 19.84 12.74 6 126792 23080 79594510
Haematochezia 19.83 12.74 72 126726 87573 79530017
Neck pain 19.80 12.74 58 126740 75359 79542231
Depressed mood 19.74 12.74 29 126769 48451 79569139
Surgery 19.71 12.74 14 126784 32752 79584838
Alveolar soft part sarcoma 19.65 12.74 7 126791 93 79617497
Hyperpyrexia 19.65 12.74 35 126763 6057 79611533
Staphylococcal bacteraemia 19.62 12.74 53 126745 12165 79605425
Azoospermia 19.60 12.74 8 126790 157 79617433
Breast cancer 19.59 12.74 15 126783 33766 79583824
Oroticaciduria 19.55 12.74 4 126794 3 79617587
Oesophageal squamous cell carcinoma metastatic 19.55 12.74 4 126794 3 79617587
Systemic infection 19.53 12.74 46 126752 9706 79607884
Myositis 19.53 12.74 71 126727 19097 79598493
Haemoperitoneum 19.52 12.74 29 126769 4314 79613276
Ischaemic stroke 19.43 12.74 104 126694 33027 79584563
Hot flush 19.40 12.74 36 126762 54841 79562749
Anti-Muellerian hormone level decreased 19.38 12.74 7 126791 97 79617493
Therapy interrupted 19.37 12.74 13 126785 31328 79586262
Sinus congestion 19.37 12.74 4 126794 19892 79597698
Mucosal toxicity 19.34 12.74 12 126786 588 79617002
Hypovolaemia 19.28 12.74 67 126731 17624 79599966
Lung abscess 19.27 12.74 28 126770 4084 79613506
Chemotherapeutic drug level increased 19.26 12.74 10 126788 347 79617243
Carotid artery dissection 19.26 12.74 10 126788 347 79617243
Pharyngeal stenosis 19.21 12.74 5 126793 20 79617570
Glaucoma 19.18 12.74 4 126794 19757 79597833
Abdominal neoplasm 19.17 12.74 12 126786 597 79616993
Enterococcal bacteraemia 19.12 12.74 24 126774 3044 79614546
Thrombocytopenia neonatal 19.02 12.74 5 126793 21 79617569
Maternal death affecting foetus 19.02 12.74 4 126794 4 79617586
Trigeminal nerve paresis 19.02 12.74 4 126794 4 79617586
Adenoviral hepatitis 18.99 12.74 14 126784 913 79616677
Ureteric dilatation 18.89 12.74 8 126790 173 79617417
Dry mouth 18.82 12.74 74 126724 87945 79529645
Granulocytopenia 18.78 12.74 50 126748 11381 79606209
Transplant rejection 18.73 12.74 4 126794 19433 79598157
Retinal ischaemia 18.67 12.74 13 126785 775 79616815
Bone erosion 18.64 12.74 3 126795 17844 79599746
Muscle twitching 18.63 12.74 8 126790 24756 79592834
Renal tubular injury 18.59 12.74 17 126781 1502 79616088
Eosinophilia 18.59 12.74 27 126771 45318 79572272
Testicular germ cell cancer metastatic 18.47 12.74 6 126792 59 79617531
Pneumonia adenoviral 18.45 12.74 11 126787 501 79617089
Immune-mediated renal disorder 18.39 12.74 8 126790 185 79617405
Choriocarcinoma 18.38 12.74 6 126792 60 79617530
Chemotherapy 18.33 12.74 18 126780 1739 79615851
Metastases to abdominal wall 18.24 12.74 8 126790 189 79617401
Colitis ulcerative 18.21 12.74 17 126781 34725 79582865
Sweat gland tumour 18.14 12.74 11 126787 517 79617073
Delusion 18.12 12.74 5 126793 20418 79597172
Organising pneumonia 18.12 12.74 48 126750 10891 79606699
Visual impairment 18.12 12.74 80 126718 92051 79525539
Procedural pain 18.11 12.74 7 126791 23077 79594513
Metastases to retroperitoneum 18.09 12.74 10 126788 394 79617196
Mental disorder 18.02 12.74 14 126784 31288 79586302
Vaginitis gardnerella 17.99 12.74 5 126793 27 79617563
Testicular cancer metastatic 17.95 12.74 6 126792 65 79617525
Thrombocytosis 17.93 12.74 41 126757 8485 79609105
Campylobacter test positive 17.79 12.74 6 126792 67 79617523
Small intestinal perforation 17.75 12.74 24 126774 3273 79614317
Peritoneal gliomatosis 17.75 12.74 4 126794 7 79617583
Body temperature decreased 17.73 12.74 15 126783 32130 79585460
Hypertension 17.72 12.74 396 126402 330596 79286994
Alopecia 17.68 12.74 260 126538 231095 79386495
Restless legs syndrome 17.68 12.74 5 126793 20087 79597503
Cerebral salt-wasting syndrome 17.56 12.74 7 126791 129 79617461
Hepatic lesion 17.54 12.74 36 126762 6923 79610667
Hernia 17.52 12.74 3 126795 17056 79600534
Vertigo 17.51 12.74 54 126744 69028 79548562
Cardiac pseudoaneurysm 17.47 12.74 6 126792 71 79617519
Rash pruritic 17.45 12.74 57 126741 71572 79546018
Median nerve injury 17.41 12.74 5 126793 31 79617559
Oral candidiasis 17.37 12.74 93 126705 29535 79588055
Malignant pleural effusion 17.29 12.74 24 126774 3356 79614234
Oxygen saturation decreased 17.29 12.74 127 126671 128920 79488670
Primitive neuroectodermal tumour 17.27 12.74 5 126793 32 79617558
Acute myelomonocytic leukaemia 17.26 12.74 9 126789 315 79617275
Paraneoplastic dermatomyositis 17.25 12.74 6 126792 74 79617516
Anaplastic lymphoma kinase gene mutation 17.22 12.74 7 126791 136 79617454
Ovarian cancer recurrent 17.21 12.74 10 126788 434 79617156
Embolism venous 17.21 12.74 27 126771 4212 79613378
Gastroenteritis viral 17.18 12.74 9 126789 24822 79592768
Pneumonia escherichia 17.12 12.74 13 126785 887 79616703
Morphoea 17.11 12.74 10 126788 439 79617151
Jugular vein occlusion 17.08 12.74 4 126794 9 79617581
Laryngeal pain 17.06 12.74 33 126765 6081 79611509
Venous thrombosis 16.98 12.74 36 126762 7080 79610510
Dementia 16.97 12.74 9 126789 24650 79592940
Cough 16.86 12.74 449 126349 366340 79251250
Ganglioneuroma 16.85 12.74 7 126791 144 79617446
Dropped head syndrome 16.80 12.74 9 126789 333 79617257
Cellulitis 16.77 12.74 103 126695 108957 79508633
Malassezia infection 16.77 12.74 5 126793 36 79617554
Upper limb fracture 16.71 12.74 4 126794 17963 79599627
Metastases to the mediastinum 16.68 12.74 11 126787 599 79616991
Dry skin 16.64 12.74 54 126744 67941 79549649
Vascular injury 16.64 12.74 14 126784 1107 79616483
B-cell lymphoma refractory 16.59 12.74 7 126791 150 79617440
Kidney infection 16.53 12.74 7 126791 21844 79595746
Leukaemic lymphoma 16.49 12.74 6 126792 85 79617505
Enterococcal sepsis 16.47 12.74 21 126777 2705 79614885
Nephropathy 16.41 12.74 43 126755 9695 79607895
Sepsis pasteurella 16.34 12.74 3 126795 0 79617590
Deafness congenital 16.34 12.74 3 126795 0 79617590
Oesophageal squamous cell carcinoma recurrent 16.34 12.74 3 126795 0 79617590
Procedural vomiting 16.33 12.74 12 126786 779 79616811
Skin exfoliation 16.26 12.74 40 126758 55060 79562530
Metapneumovirus bronchiolitis 16.26 12.74 4 126794 12 79617578
Cervix carcinoma recurrent 16.26 12.74 4 126794 12 79617578
Osteomyelitis 16.17 12.74 17 126781 32848 79584742
Gastrointestinal ischaemia 16.17 12.74 10 126788 487 79617103
Incorrect route of product administration 16.16 12.74 19 126779 34910 79582680
Depressed level of consciousness 16.08 12.74 89 126709 96563 79521027
Poor quality sleep 16.07 12.74 8 126790 22714 79594876
Marchiafava-Bignami disease 16.02 12.74 4 126794 13 79617577
Oesophageal squamous cell carcinoma 16.01 12.74 10 126788 496 79617094
Adrenocorticotropic hormone deficiency 15.98 12.74 15 126783 1370 79616220
Pericardial effusion 15.95 12.74 127 126671 46110 79571480
Pelvic fluid collection 15.95 12.74 12 126786 807 79616783
Capillary leak syndrome 15.94 12.74 25 126773 3900 79613690
Hyperlipidaemia 15.89 12.74 11 126787 26082 79591508
Live birth 15.88 12.74 5 126793 18739 79598851
Obstructive airways disorder 15.79 12.74 16 126782 31443 79586147
Retinal toxicity 15.74 12.74 15 126783 1396 79616194
Enterobacter infection 15.74 12.74 27 126771 4535 79613055
Spinal stenosis 15.74 12.74 3 126795 15788 79601802
Dyspnoea exertional 15.71 12.74 78 126720 86995 79530595
Portal vein thrombosis 15.71 12.74 31 126767 5796 79611794
Cardiac tamponade 15.67 12.74 41 126757 9235 79608355
Myasthenic syndrome 15.66 12.74 12 126786 830 79616760
Acute monocytic leukaemia 15.43 12.74 10 126788 529 79617061
Oral fungal infection 15.42 12.74 24 126774 3719 79613871
Noctiphobia 15.37 12.74 4 126794 16 79617574
Paraneoplastic syndrome 15.35 12.74 13 126785 1037 79616553
White blood cell disorder 15.34 12.74 22 126776 3170 79614420
Herpes zoster 15.33 12.74 86 126712 92997 79524593
Blood loss anaemia 15.33 12.74 3 126795 15495 79602095
Unresponsive to stimuli 15.31 12.74 42 126756 55746 79561844
Blood iron decreased 15.24 12.74 3 126795 15431 79602159
Night sweats 15.23 12.74 38 126760 52057 79565533
Carpal tunnel syndrome 15.19 12.74 6 126792 19522 79598068
Vascular pseudoaneurysm 15.15 12.74 23 126775 3487 79614103
Diabetes mellitus inadequate control 15.08 12.74 10 126788 24254 79593336
Paranoia 15.07 12.74 6 126792 19426 79598164
Fracture 14.94 12.74 8 126790 21793 79595797
Necrosis ischaemic 14.93 12.74 13 126785 1077 79616513
Thrombotic thrombocytopenic purpura 14.92 12.74 32 126766 6344 79611246
Glycosylated haemoglobin increased 14.85 12.74 6 126792 19254 79598336
Metastases to thorax 14.73 12.74 7 126791 200 79617390
Mood altered 14.70 12.74 5 126793 17842 79599748
Skin ulcer 14.69 12.74 41 126757 54109 79563481
Evans syndrome 14.67 12.74 9 126789 432 79617158
Hypoglossal nerve paresis 14.64 12.74 6 126792 119 79617471
Immune-mediated enterocolitis 14.63 12.74 27 126771 4803 79612787
Carotid artery thrombosis 14.61 12.74 21 126777 3032 79614558
Hypoxia 14.58 12.74 238 126560 103005 79514585
Respiratory arrest 14.58 12.74 45 126753 57505 79560085
Thrombophlebitis migrans 14.56 12.74 9 126789 438 79617152
Intestinal infarction 14.52 12.74 14 126784 1322 79616268
Device malfunction 14.51 12.74 8 126790 21440 79596150
Gastroenteritis pseudomonas 14.50 12.74 5 126793 60 79617530
Pneumonia salmonella 14.50 12.74 5 126793 60 79617530
Coma 14.49 12.74 97 126701 100552 79517038
Mydriasis 14.43 12.74 5 126793 17638 79599952
Haemorrhoids 14.41 12.74 15 126783 29113 79588477
BRAF gene mutation 14.35 12.74 5 126793 62 79617528
Hyperglycaemic hyperosmolar nonketotic syndrome 14.33 12.74 18 126780 2285 79615305
Toxic leukoencephalopathy 14.29 12.74 13 126785 1141 79616449
Thymus enlargement 14.28 12.74 6 126792 127 79617463
Eastern Cooperative Oncology Group performance status worsened 14.24 12.74 17 126781 2048 79615542
Mucosal erosion 14.23 12.74 18 126780 2300 79615290
Eczema 14.23 12.74 27 126771 40791 79576799
Chest pain 14.19 12.74 341 126457 281963 79335627
Conjunctivitis 14.18 12.74 12 126786 25703 79591887
Cell-mediated immune deficiency 14.16 12.74 6 126792 130 79617460
Laryngitis 14.10 12.74 4 126794 16035 79601555
Platelet transfusion 14.09 12.74 18 126780 2324 79615266
Pulmonary artery thrombosis 14.04 12.74 14 126784 1378 79616212
Feeling cold 13.98 12.74 15 126783 28714 79588876
Laryngeal cancer stage IV 13.90 12.74 4 126794 25 79617565
Stent malfunction 13.87 12.74 5 126793 69 79617521
Sneezing 13.82 12.74 7 126791 19676 79597914
Drug level decreased 13.80 12.74 3 126795 14399 79603191
Oesophageal prosthesis insertion 13.80 12.74 3 126795 4 79617586
VIth nerve paresis 13.79 12.74 6 126792 139 79617451
Endothelial dysfunction 13.77 12.74 7 126791 232 79617358
Fear 13.75 12.74 9 126789 21977 79595613
Pseudocellulitis 13.73 12.74 5 126793 71 79617519
Culture urine positive 13.69 12.74 25 126773 4410 79613180
Vitamin D deficiency 13.63 12.74 3 126795 14276 79603314
Neoplasm malignant 13.62 12.74 92 126706 31718 79585872
Conductive deafness 13.61 12.74 7 126791 238 79617352
Mania 13.58 12.74 6 126792 18254 79599336
Metastases to pelvis 13.57 12.74 10 126788 652 79616938
Adenocarcinoma of appendix 13.55 12.74 5 126793 74 79617516
Delirium 13.50 12.74 79 126719 84548 79533042
Procedural nausea 13.50 12.74 11 126787 832 79616758
Infective spondylitis 13.41 12.74 9 126789 505 79617085
Post procedural diarrhoea 13.41 12.74 10 126788 664 79616926
Spinal column injury 13.39 12.74 17 126781 2181 79615409
Rotator cuff syndrome 13.38 12.74 3 126795 14092 79603498
Ovarian failure 13.38 12.74 10 126788 666 79616924
Non-small cell lung cancer metastatic 13.38 12.74 12 126786 1034 79616556
Pneumocystis jirovecii pneumonia 13.32 12.74 93 126705 32415 79585175
Hypothermia 13.31 12.74 10 126788 22736 79594854
Squamous cell carcinoma of the cervix 13.30 12.74 7 126791 250 79617340
Colony stimulating factor therapy 13.25 12.74 9 126789 515 79617075
Hemianopia 13.21 12.74 15 126783 1713 79615877
Injection site rash 13.19 12.74 6 126792 17948 79599642
Intestinal metastasis 13.16 12.74 8 126790 378 79617212
Treatment noncompliance 13.15 12.74 41 126757 52227 79565363
Streptococcus test positive 13.15 12.74 17 126781 2221 79615369
Gastroenteritis sapovirus 13.11 12.74 6 126792 157 79617433
Dystonia 13.06 12.74 9 126789 21390 79596200
Peritoneal sarcoma 13.05 12.74 3 126795 6 79617584
Ecchymosis 12.98 12.74 4 126794 15202 79602388
Adenocarcinoma gastric 12.98 12.74 15 126783 1746 79615844
Metastases to kidney 12.95 12.74 9 126789 535 79617055
Facial paralysis 12.94 12.74 67 126731 21005 79596585
Chromosomal deletion 12.94 12.74 6 126792 162 79617428
Oesophageal haemorrhage 12.94 12.74 15 126783 1752 79615838
Brachiocephalic vein thrombosis 12.90 12.74 7 126791 266 79617324
Malignant peritoneal neoplasm 12.89 12.74 10 126788 704 79616886
Retroperitoneal lymphadenopathy 12.86 12.74 12 126786 1088 79616502
Synovial sarcoma 12.86 12.74 5 126793 86 79617504
Blastic plasmacytoid dendritic cell neoplasia 12.86 12.74 5 126793 86 79617504
Respiratory depression 12.82 12.74 15 126783 27615 79589975
Drug-device interaction 12.81 12.74 5 126793 87 79617503
Lymphangioleiomyomatosis 12.77 12.74 6 126792 167 79617423
Hepatic artery occlusion 12.75 12.74 5 126793 88 79617502

FDA Adverse Event Reporting System (Pediatric)

None

Pharmacologic Action:

SourceCodeDescription
ATC L01XA01 ANTINEOPLASTIC AND IMMUNOMODULATING AGENTS
ANTINEOPLASTIC AGENTS
OTHER ANTINEOPLASTIC AGENTS
Platinum compounds
FDA EXT N0000175073 Platinum-containing Compounds
FDA EPC N0000175413 Platinum-based Drug
MeSH PA D000970 Antineoplastic Agents
MeSH PA D003432 Cross-Linking Reagents
MeSH PA D007202 Indicators and Reagents
MeSH PA D011838 Radiation-Sensitizing Agents
CHEBI has role CHEBI:25435 mutagens
CHEBI has role CHEBI:35610 antineoplastic agents
CHEBI has role CHEBI:47868 photosensitising agent
CHEBI has role CHEBI:50684 cross-linking reagents
CHEBI has role CHEBI:50902 genotoxic agent
CHEBI has role CHEBI:61015 nephrotoxins
CHEBI has role CHEBI:68495 Type I cell-death inducers
CHEBI has role CHEBI:173085 ferroptosis inducers

Drug Use | Suggest Off label Use Form| |View source of the data|

DiseaseRelationSNOMED_IDDOID
Malignant tumor of ovary indication 363443007 DOID:2394
Ovarian Germ Cell Tumor Carcinoma indication
Testicular Germ Cell Tumor indication
Invasive Bladder Malignancy indication




๐Ÿถ Veterinary Drug Use

None

๐Ÿถ Veterinary products

None

Acid dissociation constants calculated using MoKa v3.0.0

None

Orange Book patent data (new drug applications)

None

Orange Book exclusivity data (new drug applications)

None

Bioactivity Summary:

TargetClassPharosUniProtActionTypeActivity value
(-log[M])
Mechanism
action
Bioact sourceMoA source
D(3) dopamine receptor GPCR Ki 5.95 CHEMBL
Muscarinic acetylcholine receptor M5 GPCR Ki 5.37 CHEMBL
Canalicular multispecific organic anion transporter 1 Transporter WOMBAT-PK
Adenosine receptor A3 GPCR Ki 5.62 DRUG MATRIX
Multidrug resistance-associated protein 6 Transporter WOMBAT-PK
Multidrug resistance-associated protein 5 Transporter WOMBAT-PK
Epidermal growth factor receptor Kinase IC50 5.58 DRUG MATRIX
Tyrosine-protein kinase Lck Kinase IC50 4.64 DRUG MATRIX
Tyrosine-protein kinase Fyn Kinase IC50 5.32 DRUG MATRIX
C-X-C chemokine receptor type 2 GPCR Ki 5.02 DRUG MATRIX
Thromboxane-A synthase Enzyme IC50 5.03 DRUG MATRIX
C-C chemokine receptor type 2 GPCR Ki 5.15 DRUG MATRIX
Mitogen-activated protein kinase 3 Kinase IC50 5.34 DRUG MATRIX
Melanocortin receptor 5 GPCR Ki 5.22 DRUG MATRIX
Sodium/potassium-transporting ATPase subunit alpha-2 Ion channel IC50 5.03 DRUG MATRIX

External reference:

IDSource
D00275 KEGG_DRUG
4018139 VUID
N0000146476 NUI
4018139 VANDF
C0008838 UMLSCUI
CHEBI:27899 CHEBI
CPT PDB_CHEM_ID
CHEMBL1386 ChEMBL_ID
CHEMBL11359 ChEMBL_ID
CHEMBL2068237 ChEMBL_ID
DB00515 DRUGBANK_ID
5343 IUPHAR_LIGAND_ID
4426 INN_ID
Q20Q21Q62J UNII
5702198 PUBCHEM_CID
2555 RXNORM
31747 MMSL
4456 MMSL
d00195 MMSL
002641 NDDF
387318005 SNOMEDCT_US
57066004 SNOMEDCT_US
D002945 MESH_DESCRIPTOR_UI

Pharmaceutical products:

ProductCategoryIngredientsNDCFormQuantityRouteMarketingLabel
CISplatin HUMAN PRESCRIPTION DRUG LABEL 1 0143-9504 INJECTION 1 mg INTRAVENOUS ANDA 19 sections
CISplatin HUMAN PRESCRIPTION DRUG LABEL 1 0143-9505 INJECTION 1 mg INTRAVENOUS ANDA 19 sections
Cisplatin HUMAN PRESCRIPTION DRUG LABEL 1 0703-5747 INJECTION, SOLUTION 50 mg INTRAVENOUS ANDA 29 sections
Cisplatin HUMAN PRESCRIPTION DRUG LABEL 1 0703-5747 INJECTION, SOLUTION 50 mg INTRAVENOUS ANDA 29 sections
Cisplatin HUMAN PRESCRIPTION DRUG LABEL 1 0703-5748 INJECTION, SOLUTION 100 mg INTRAVENOUS ANDA 29 sections
Cisplatin HUMAN PRESCRIPTION DRUG LABEL 1 0703-5748 INJECTION, SOLUTION 100 mg INTRAVENOUS ANDA 29 sections
Cisplatin HUMAN PRESCRIPTION DRUG LABEL 1 16729-288 INJECTION 1 mg INTRAVENOUS ANDA 26 sections
Cisplatin HUMAN PRESCRIPTION DRUG LABEL 1 25021-253 INJECTION, SOLUTION 1 mg INTRAVENOUS ANDA 21 sections
CISplatin HUMAN PRESCRIPTION DRUG LABEL 1 44567-509 INJECTION, SOLUTION 1 mg INTRAVENOUS NDA 19 sections
CISplatin HUMAN PRESCRIPTION DRUG LABEL 1 44567-510 INJECTION, SOLUTION 1 mg INTRAVENOUS NDA 19 sections
CISplatin HUMAN PRESCRIPTION DRUG LABEL 1 44567-511 INJECTION, SOLUTION 1 mg INTRAVENOUS NDA 19 sections
Cisplatin HUMAN PRESCRIPTION DRUG LABEL 1 44567-530 INJECTION, POWDER, LYOPHILIZED, FOR SOLUTION 1 mg INTRAVENOUS NDA 26 sections
CISplatin HUMAN PRESCRIPTION DRUG LABEL 1 60505-6277 INJECTION, SOLUTION 50 mg INTRAVENOUS Unapproved drug for use in drug shortage 2 sections
Cisplatin HUMAN PRESCRIPTION DRUG LABEL 1 63323-103 INJECTION, SOLUTION 1 mg INTRAVENOUS ANDA 13 sections
Cisplatin HUMAN PRESCRIPTION DRUG LABEL 1 68001-283 INJECTION 1 mg INTRAVENOUS ANDA 26 sections
CISPLATIN Human Prescription Drug Label 1 68083-162 INJECTION, SOLUTION 1 mg INTRAVENOUS ANDA 13 sections
CISPLATIN Human Prescription Drug Label 1 68083-163 INJECTION, SOLUTION 1 mg INTRAVENOUS ANDA 13 sections
Cisplatin HUMAN PRESCRIPTION DRUG LABEL 1 70860-206 INJECTION, SOLUTION 1 mg INTRAVENOUS ANDA 21 sections
CISPLATIN HUMAN PRESCRIPTION DRUG LABEL 1 72266-252 INJECTION, SOLUTION 1 mg INTRAVENOUS ANDA 13 sections
CISPLATIN HUMAN PRESCRIPTION DRUG LABEL 1 72266-253 INJECTION, SOLUTION 1 mg INTRAVENOUS ANDA 13 sections