dapoxetine 🐶 Veterinary Use | Indications/Contra | FAERs-F | FAERs-M | Orange Bk | BioActivity |
| Stem definition | Drug id | CAS RN |
|---|---|---|
| serotonin and/or norepinephrine reuptake inhibitors, fluoxetine derivatives | 4381 | 119356-77-3 |
Description:
| Molecule | Description |
|---|---|
|
Synonyms:
|
selective serotonin reuptake inhibitor (SSRI) that was designed specifically for premature ejaculation
|
Drug dosage:
| Dose | Unit | Route |
|---|---|---|
| 30 | mg | O |
ADMET properties:
| Property | Value | Reference |
|---|---|---|
| S (Water solubility) | 25.64 mg/mL | Bocci G, Oprea TI, Benet LZ |
| BDDCS (Biopharmaceutical Drug Disposition Classification System) | 1 | Bocci G, Oprea TI, Benet LZ |
Approvals:
None
FDA Adverse Event Reporting System (Female)
None
FDA Adverse Event Reporting System (Male)
None
FDA Adverse Event Reporting System (Geriatric)
None
FDA Adverse Event Reporting System (Pediatric)
None
Pharmacologic Action:
| Source | Code | Description |
|---|---|---|
| ATC | G04BX14 | GENITO URINARY SYSTEM AND SEX HORMONES UROLOGICALS UROLOGICALS Other urologicals |
Drug Use | Suggest Off label Use Form| |View source of the data|
| Disease | Relation | SNOMED_ID | DOID |
|---|---|---|---|
| Premature ejaculation | indication | 44001008 | DOID:13709 |
🐶 Veterinary Drug Use
None
🐶 Veterinary products
None
Acid dissociation constants calculated using MoKa v3.0.0
| Dissociation level | Dissociation constant | Type (acidic/basic) |
|---|---|---|
| pKa1 | 8.52 | Basic |
Orange Book patent data (new drug applications)
None
Orange Book exclusivity data (new drug applications)
None
Bioactivity Summary:
| Target | Class | Pharos | UniProt | Action | Type | Activity value (-log[M]) | Mechanism action | Bioact source | MoA source |
|---|---|---|---|---|---|---|---|---|---|
| Sodium-dependent serotonin transporter | Transporter | INHIBITOR | IC50 | 8.95 | IUPHAR | IUPHAR |
External reference:
| ID | Source |
|---|---|
| C0215087 | UMLSCUI |
| CHEBI:135962 | CHEBI |
| D03649 | KEGG_DRUG |
| CHEMBL2110900 | ChEMBL_ID |
| DB04884 | DRUGBANK_ID |
| C080598 | MESH_SUPPLEMENTAL_RECORD_UI |
| 7901 | IUPHAR_LIGAND_ID |
| 6834 | INN_ID |
| 129938-20-1 | SECONDARY_CAS_RN |
| GB2433A4M3 | UNII |
| 71353 | PUBCHEM_CID |
| 015051 | NDDF |
| 015052 | NDDF |
| 702794006 | SNOMEDCT_US |
| 734472002 | SNOMEDCT_US |
| CHEMBL2106574 | ChEMBL_ID |
Pharmaceutical products:
None