Stem definition | Drug id | CAS RN |
---|---|---|
4380 | 93413-62-8 |
Dose | Unit | Route |
---|---|---|
50 | mg | O |
Property | Value | Reference |
---|---|---|
BDDCS (Biopharmaceutical Drug Disposition Classification System) | 3 | Benet LZ, Broccatelli F, Oprea TI |
S (Water solubility) | 572 mg/mL | Benet LZ, Broccatelli F, Oprea TI |
EoM (Fraction excreted unchanged in urine) | 45 % | Benet LZ, Broccatelli F, Oprea TI |
MRTD (Maximum Recommended Therapeutic Daily Dose) | 5.42 ยตM/kg/day | Contrera JF, Matthews EJ, Kruhlak NL, Benz RD |
Vd (Volume of distribution) | 3.50 L/kg | Lombardo F, Berellini G, Obach RS |
CL (Clearance) | 4.90 mL/min/kg | Lombardo F, Berellini G, Obach RS |
fu (Fraction unbound in plasma) | 0.70 % | Lombardo F, Berellini G, Obach RS |
t_half (Half-life) | 8.40 hours | Lombardo F, Berellini G, Obach RS |
Date | Agency | Company | Orphan |
---|---|---|---|
Feb. 29, 2008 | FDA | WYETH PHARMS INC |
MedDRA adverse event term | Likelihood ratio | Likelihood ratio threshold | Patients taking drug having adverse event | Patients taking drug not having adverse event | Patients not taking drug having adverse event | Patients not taking drug not having adverse event |
---|---|---|---|---|---|---|
Product residue present | 752.66 | 15.15 | 197 | 21967 | 3475 | 50579485 |
Drug withdrawal syndrome | 632.85 | 15.15 | 278 | 21886 | 24803 | 50558157 |
Suicidal ideation | 342.30 | 15.15 | 243 | 21921 | 55142 | 50527818 |
Withdrawal syndrome | 288.70 | 15.15 | 145 | 22019 | 17445 | 50565515 |
Feeling abnormal | 275.77 | 15.15 | 306 | 21858 | 125186 | 50457774 |
Crying | 268.33 | 15.15 | 145 | 22019 | 20271 | 50562689 |
Anxiety | 231.97 | 15.15 | 334 | 21830 | 177272 | 50405688 |
Insomnia | 218.39 | 15.15 | 322 | 21842 | 174543 | 50408417 |
Irritability | 197.18 | 15.15 | 134 | 22030 | 28292 | 50554668 |
Dizziness | 167.27 | 15.15 | 426 | 21738 | 345943 | 50237017 |
Anger | 133.73 | 15.15 | 75 | 22089 | 11258 | 50571702 |
Nausea | 130.22 | 15.15 | 630 | 21534 | 704768 | 49878192 |
Hyperhidrosis | 113.26 | 15.15 | 166 | 21998 | 89260 | 50493700 |
Headache | 109.94 | 15.15 | 475 | 21689 | 506060 | 50076900 |
Condition aggravated | 98.92 | 15.15 | 320 | 21844 | 296738 | 50286222 |
Panic attack | 94.95 | 15.15 | 74 | 22090 | 19268 | 50563692 |
Nervousness | 92.86 | 15.15 | 85 | 22079 | 27566 | 50555394 |
Agitation | 90.17 | 15.15 | 114 | 22050 | 53270 | 50529690 |
Depression | 88.51 | 15.15 | 212 | 21952 | 165211 | 50417749 |
Tremor | 87.59 | 15.15 | 170 | 21994 | 114733 | 50468227 |
Emotional disorder | 87.31 | 15.15 | 58 | 22106 | 11778 | 50571182 |
Abnormal dreams | 84.16 | 15.15 | 52 | 22112 | 9325 | 50573635 |
Intentional product misuse | 84.05 | 15.15 | 103 | 22061 | 46631 | 50536329 |
Feeling jittery | 73.54 | 15.15 | 51 | 22113 | 11109 | 50571851 |
Suicide attempt | 63.95 | 15.15 | 95 | 22069 | 51637 | 50531323 |
Nightmare | 63.07 | 15.15 | 54 | 22110 | 16032 | 50566928 |
Completed suicide | 62.04 | 15.15 | 161 | 22003 | 131728 | 50451232 |
Thinking abnormal | 61.35 | 15.15 | 43 | 22121 | 9524 | 50573436 |
Persistent genital arousal disorder | 58.80 | 15.15 | 15 | 22149 | 237 | 50582723 |
Serotonin syndrome | 51.93 | 15.15 | 59 | 22105 | 24654 | 50558306 |
Disturbance in attention | 50.12 | 15.15 | 65 | 22099 | 31121 | 50551839 |
Overdose | 49.21 | 15.15 | 124 | 22040 | 99603 | 50483357 |
Middle insomnia | 48.77 | 15.15 | 38 | 22126 | 9883 | 50573077 |
Migraine | 47.41 | 15.15 | 103 | 22061 | 75177 | 50507783 |
Paraesthesia | 46.80 | 15.15 | 137 | 22027 | 120106 | 50462854 |
Seizure | 43.69 | 15.15 | 132 | 22032 | 117742 | 50465218 |
Drug ineffective | 43.68 | 15.15 | 548 | 21616 | 818785 | 49764175 |
Depressed mood | 42.78 | 15.15 | 63 | 22101 | 33960 | 50549000 |
Vision blurred | 42.20 | 15.15 | 101 | 22063 | 78546 | 50504414 |
Acute kidney injury | 41.79 | 15.15 | 24 | 22140 | 228034 | 50354926 |
Anaemia | 41.58 | 15.15 | 30 | 22134 | 252426 | 50330534 |
Pyrexia | 41.56 | 15.15 | 64 | 22100 | 380139 | 50202821 |
Mania | 41.48 | 15.15 | 36 | 22128 | 10880 | 50572080 |
Drug screen positive | 41.45 | 15.15 | 23 | 22141 | 3379 | 50579581 |
Tinnitus | 41.15 | 15.15 | 56 | 22108 | 28076 | 50554884 |
Mydriasis | 40.29 | 15.15 | 35 | 22129 | 10592 | 50572368 |
Synovitis | 39.88 | 15.15 | 4 | 22160 | 123861 | 50459099 |
Anorgasmia | 38.98 | 15.15 | 13 | 22151 | 542 | 50582418 |
Death | 38.27 | 15.15 | 52 | 22112 | 325327 | 50257633 |
Energy increased | 38.20 | 15.15 | 19 | 22145 | 2233 | 50580727 |
Impaired driving ability | 38.19 | 15.15 | 23 | 22141 | 3938 | 50579022 |
Product substitution issue | 37.34 | 15.15 | 38 | 22126 | 14019 | 50568941 |
Coma scale abnormal | 36.69 | 15.15 | 24 | 22140 | 4747 | 50578213 |
Neutropenia | 36.19 | 15.15 | 10 | 22154 | 147955 | 50435005 |
Joint swelling | 35.61 | 15.15 | 33 | 22131 | 245253 | 50337707 |
Somnolence | 35.39 | 15.15 | 148 | 22016 | 154837 | 50428123 |
Maternal exposure during pregnancy | 35.17 | 15.15 | 13 | 22151 | 159765 | 50423195 |
Blood pressure increased | 35.11 | 15.15 | 133 | 22031 | 132999 | 50449961 |
Mood altered | 34.79 | 15.15 | 35 | 22129 | 12738 | 50570222 |
Treatment failure | 34.23 | 15.15 | 9 | 22155 | 137628 | 50445332 |
Drug screen false positive | 34.04 | 15.15 | 13 | 22151 | 806 | 50582154 |
Aggression | 33.90 | 15.15 | 44 | 22120 | 21072 | 50561888 |
Systemic lupus erythematosus | 33.47 | 15.15 | 10 | 22154 | 140612 | 50442348 |
Pre-existing condition improved | 32.34 | 15.15 | 26 | 22138 | 7071 | 50575889 |
Therapeutic response unexpected | 31.75 | 15.15 | 37 | 22127 | 15878 | 50567082 |
Weight increased | 31.70 | 15.15 | 173 | 21991 | 201718 | 50381242 |
Stomatitis | 30.80 | 15.15 | 4 | 22160 | 101340 | 50481620 |
Restlessness | 30.76 | 15.15 | 46 | 22118 | 25127 | 50557833 |
Peripheral swelling | 30.72 | 15.15 | 27 | 22137 | 205909 | 50377051 |
Thrombocytopenia | 30.53 | 15.15 | 9 | 22155 | 127664 | 50455296 |
Drug hypersensitivity | 30.41 | 15.15 | 201 | 21963 | 250809 | 50332151 |
Bruxism | 30.21 | 15.15 | 18 | 22146 | 3022 | 50579938 |
Infusion related reaction | 29.43 | 15.15 | 19 | 22145 | 169538 | 50413422 |
Paranoia | 29.37 | 15.15 | 29 | 22135 | 10319 | 50572641 |
General physical health deterioration | 29.05 | 15.15 | 13 | 22151 | 142421 | 50440539 |
Mood swings | 28.40 | 15.15 | 35 | 22129 | 15919 | 50567041 |
Palpitations | 27.93 | 15.15 | 98 | 22066 | 94408 | 50488552 |
Nonspecific reaction | 27.22 | 15.15 | 14 | 22150 | 1765 | 50581195 |
Rheumatoid arthritis | 26.27 | 15.15 | 30 | 22134 | 202520 | 50380440 |
Libido decreased | 26.07 | 15.15 | 15 | 22149 | 2361 | 50580599 |
Sepsis | 25.77 | 15.15 | 13 | 22151 | 132912 | 50450048 |
Amnesia | 25.66 | 15.15 | 57 | 22107 | 42203 | 50540757 |
Tachyphrenia | 25.65 | 15.15 | 12 | 22152 | 1233 | 50581727 |
Abnormal behaviour | 25.58 | 15.15 | 37 | 22127 | 19621 | 50563339 |
Euphoric mood | 25.47 | 15.15 | 18 | 22146 | 4037 | 50578923 |
Mental disorder | 25.19 | 15.15 | 39 | 22125 | 21952 | 50561008 |
Hostility | 24.35 | 15.15 | 13 | 22151 | 1769 | 50581191 |
Infection | 24.23 | 15.15 | 24 | 22140 | 172930 | 50410030 |
Pericarditis | 24.16 | 15.15 | 3 | 22161 | 78686 | 50504274 |
Lower respiratory tract infection | 24.09 | 15.15 | 6 | 22158 | 95195 | 50487765 |
Dissociation | 23.91 | 15.15 | 14 | 22150 | 2277 | 50580683 |
Hypersensitivity vasculitis | 23.33 | 15.15 | 17 | 22147 | 3998 | 50578962 |
Loss of libido | 22.78 | 15.15 | 11 | 22153 | 1212 | 50581748 |
Panic reaction | 22.78 | 15.15 | 16 | 22148 | 3553 | 50579407 |
Stress | 22.56 | 15.15 | 63 | 22101 | 53730 | 50529230 |
Unevaluable event | 22.40 | 15.15 | 57 | 22107 | 46009 | 50536951 |
Post-traumatic stress disorder | 22.28 | 15.15 | 17 | 22147 | 4286 | 50578674 |
Prescribed overdose | 21.25 | 15.15 | 29 | 22135 | 14571 | 50568389 |
Bipolar disorder | 21.18 | 15.15 | 20 | 22144 | 6737 | 50576223 |
Apathy | 21.14 | 15.15 | 21 | 22143 | 7527 | 50575433 |
Pneumonia | 20.30 | 15.15 | 91 | 22073 | 378310 | 50204650 |
Muscle twitching | 20.01 | 15.15 | 29 | 22135 | 15402 | 50567558 |
Hallucination | 19.92 | 15.15 | 55 | 22109 | 46602 | 50536358 |
Negative thoughts | 19.88 | 15.15 | 9 | 22155 | 857 | 50582103 |
Swelling | 19.87 | 15.15 | 36 | 22128 | 200836 | 50382124 |
Arthropathy | 19.81 | 15.15 | 24 | 22140 | 157882 | 50425078 |
Febrile neutropenia | 19.77 | 15.15 | 9 | 22155 | 97658 | 50485302 |
Brain injury | 19.23 | 15.15 | 18 | 22146 | 5996 | 50576964 |
Dyspnoea | 19.15 | 15.15 | 151 | 22013 | 547457 | 50035503 |
Suicidal behaviour | 18.58 | 15.15 | 12 | 22152 | 2322 | 50580638 |
Wrong technique in product usage process | 18.54 | 15.15 | 60 | 22104 | 55450 | 50527510 |
Memory impairment | 18.25 | 15.15 | 76 | 22088 | 79284 | 50503676 |
Tardive dyskinesia | 18.11 | 15.15 | 19 | 22145 | 7260 | 50575700 |
Tearfulness | 17.86 | 15.15 | 14 | 22150 | 3673 | 50579287 |
Intestinal pseudo-obstruction | 17.83 | 15.15 | 8 | 22156 | 746 | 50582214 |
Change in seizure presentation | 17.55 | 15.15 | 6 | 22158 | 270 | 50582690 |
Malaise | 17.51 | 15.15 | 224 | 21940 | 335308 | 50247652 |
Haemoglobin decreased | 17.41 | 15.15 | 18 | 22146 | 127198 | 50455762 |
Renal impairment | 16.90 | 15.15 | 6 | 22158 | 75655 | 50507305 |
Hallucination, auditory | 16.67 | 15.15 | 22 | 22142 | 10706 | 50572254 |
Urinary tract infection | 16.58 | 15.15 | 47 | 22117 | 223973 | 50358987 |
Dry mouth | 16.37 | 15.15 | 58 | 22106 | 56120 | 50526840 |
Yawning | 16.21 | 15.15 | 8 | 22156 | 925 | 50582035 |
Impatience | 16.09 | 15.15 | 6 | 22158 | 348 | 50582612 |
Decreased interest | 15.95 | 15.15 | 12 | 22152 | 2964 | 50579996 |
Feeling drunk | 15.84 | 15.15 | 13 | 22151 | 3640 | 50579320 |
Blood triglycerides increased | 15.76 | 15.15 | 22 | 22142 | 11290 | 50571670 |
Galactorrhoea | 15.62 | 15.15 | 13 | 22151 | 3710 | 50579250 |
Wound | 15.60 | 15.15 | 14 | 22150 | 105780 | 50477180 |
Coma | 15.57 | 15.15 | 3 | 22161 | 56876 | 50526084 |
Wernicke-Korsakoff syndrome | 15.46 | 15.15 | 4 | 22160 | 67 | 50582893 |
Impaired work ability | 15.36 | 15.15 | 24 | 22140 | 13616 | 50569344 |
Drug effective for unapproved indication | 15.19 | 15.15 | 10 | 22154 | 1999 | 50580961 |
MedDRA adverse event term | Likelihood ratio | Likelihood ratio threshold | Patients taking drug having adverse event | Patients taking drug not having adverse event | Patients not taking drug having adverse event | Patients not taking drug not having adverse event |
---|---|---|---|---|---|---|
Product residue present | 225.41 | 22.80 | 60 | 6027 | 2479 | 29565961 |
Drug withdrawal syndrome | 170.05 | 22.80 | 80 | 6007 | 17904 | 29550536 |
Serotonin syndrome | 141.61 | 22.80 | 70 | 6017 | 17442 | 29550998 |
Suicidal ideation | 118.41 | 22.80 | 79 | 6008 | 34637 | 29533803 |
Anxiety | 90.28 | 22.80 | 99 | 5988 | 85266 | 29483174 |
Hyperhidrosis | 73.70 | 22.80 | 78 | 6009 | 64462 | 29503978 |
Suicide attempt | 65.43 | 22.80 | 55 | 6032 | 34055 | 29534385 |
Overdose | 61.82 | 22.80 | 79 | 6008 | 79740 | 29488700 |
Sexual dysfunction | 58.39 | 22.80 | 27 | 6060 | 5787 | 29562653 |
Withdrawal syndrome | 52.48 | 22.80 | 31 | 6056 | 10961 | 29557479 |
Insomnia | 50.89 | 22.80 | 76 | 6011 | 88685 | 29479755 |
Feeling abnormal | 50.40 | 22.80 | 59 | 6028 | 54386 | 29514054 |
Anger | 50.13 | 22.80 | 30 | 6057 | 10860 | 29557580 |
Major depression | 45.47 | 22.80 | 20 | 6067 | 3815 | 29564625 |
Drug ineffective | 45.19 | 22.80 | 170 | 5917 | 363000 | 29205440 |
Thinking abnormal | 39.53 | 22.80 | 20 | 6067 | 5216 | 29563224 |
Completed suicide | 39.02 | 22.80 | 68 | 6019 | 90178 | 29478262 |
Erectile dysfunction | 36.50 | 22.80 | 30 | 6057 | 17979 | 29550461 |
Schizophreniform disorder | 35.65 | 22.80 | 7 | 6080 | 70 | 29568370 |
Coma scale abnormal | 34.49 | 22.80 | 16 | 6071 | 3453 | 29564987 |
Nervousness | 34.37 | 22.80 | 24 | 6063 | 11282 | 29557158 |
Dry mouth | 33.48 | 22.80 | 31 | 6056 | 21753 | 29546687 |
Depression | 30.29 | 22.80 | 59 | 6028 | 85088 | 29483352 |
Mania | 30.16 | 22.80 | 20 | 6067 | 8643 | 29559797 |
Headache | 29.93 | 22.80 | 91 | 5996 | 173916 | 29394524 |
Libido decreased | 28.36 | 22.80 | 15 | 6072 | 4283 | 29564157 |
Tremor | 27.43 | 22.80 | 52 | 6035 | 73486 | 29494954 |
Drug screen positive | 27.18 | 22.80 | 14 | 6073 | 3787 | 29564653 |
Abnormal behaviour | 26.42 | 22.80 | 28 | 6059 | 23099 | 29545341 |
Irritability | 25.63 | 22.80 | 27 | 6060 | 22125 | 29546315 |
Paralysis | 24.92 | 22.80 | 15 | 6072 | 5482 | 29562958 |
Acute kidney injury | 24.57 | 22.80 | 12 | 6075 | 265255 | 29303185 |
Drug screen false positive | 24.51 | 22.80 | 8 | 6079 | 672 | 29567768 |
Dizziness | 24.43 | 22.80 | 90 | 5997 | 189594 | 29378846 |
Paraesthesia | 23.79 | 22.80 | 41 | 6046 | 53804 | 29514636 |
Emotional disorder | 23.77 | 22.80 | 14 | 6073 | 4917 | 29563523 |
Intentional product misuse | 23.21 | 22.80 | 32 | 6055 | 34629 | 29533811 |
Bipolar disorder | 23.17 | 22.80 | 12 | 6075 | 3283 | 29565157 |
MedDRA adverse event term | Likelihood ratio | Likelihood ratio threshold | Patients taking drug having adverse event | Patients taking drug not having adverse event | Patients not taking drug having adverse event | Patients not taking drug not having adverse event |
---|---|---|---|---|---|---|
Withdrawal syndrome | 278.99 | 15.26 | 135 | 18060 | 23357 | 64457180 |
Drug withdrawal syndrome | 234.30 | 15.26 | 132 | 18063 | 31159 | 64449378 |
Suicidal ideation | 219.58 | 15.26 | 168 | 18027 | 66374 | 64414163 |
Feeling abnormal | 208.52 | 15.26 | 221 | 17974 | 133381 | 64347156 |
Product residue present | 183.69 | 15.26 | 58 | 18137 | 3184 | 64477353 |
Anxiety | 175.58 | 15.26 | 249 | 17946 | 202400 | 64278137 |
Crying | 164.72 | 15.26 | 90 | 18105 | 20000 | 64460537 |
Serotonin syndrome | 140.19 | 15.26 | 104 | 18091 | 39178 | 64441359 |
Irritability | 126.02 | 15.26 | 95 | 18100 | 36651 | 64443886 |
Overdose | 115.00 | 15.26 | 180 | 18015 | 159386 | 64321151 |
Anger | 103.36 | 15.26 | 61 | 18134 | 15680 | 64464857 |
Insomnia | 100.31 | 15.26 | 191 | 18004 | 197645 | 64282892 |
Suicide attempt | 99.32 | 15.26 | 111 | 18084 | 70896 | 64409641 |
Dizziness | 86.56 | 15.26 | 292 | 17903 | 429871 | 64050666 |
Completed suicide | 85.91 | 15.26 | 193 | 18002 | 224221 | 64256316 |
Hyperhidrosis | 81.83 | 15.26 | 135 | 18060 | 124785 | 64355752 |
Emotional disorder | 77.93 | 15.26 | 47 | 18148 | 12560 | 64467977 |
Depression | 75.05 | 15.26 | 162 | 18033 | 183129 | 64297408 |
Coma scale abnormal | 69.78 | 15.26 | 37 | 18158 | 7737 | 64472800 |
Headache | 67.93 | 15.26 | 312 | 17883 | 529155 | 63951382 |
Persistent genital arousal disorder | 65.78 | 15.26 | 15 | 18180 | 230 | 64480307 |
Drug ineffective | 64.18 | 15.26 | 430 | 17765 | 839817 | 63640720 |
Nausea | 62.31 | 15.26 | 406 | 17789 | 785394 | 63695143 |
Drug hypersensitivity | 62.14 | 15.26 | 177 | 18018 | 237638 | 64242899 |
Tremor | 61.78 | 15.26 | 132 | 18063 | 148098 | 64332439 |
Nervousness | 59.06 | 15.26 | 56 | 18139 | 29500 | 64451037 |
Intentional product misuse | 56.84 | 15.26 | 85 | 18110 | 72210 | 64408327 |
Panic attack | 56.41 | 15.26 | 47 | 18148 | 20906 | 64459631 |
Acute kidney injury | 55.23 | 15.26 | 29 | 18166 | 449211 | 64031326 |
Depressed mood | 52.05 | 15.26 | 61 | 18134 | 40951 | 64439586 |
Thinking abnormal | 51.37 | 15.26 | 35 | 18160 | 11521 | 64469016 |
Product substitution issue | 47.94 | 15.26 | 40 | 18155 | 17821 | 64462716 |
Abnormal dreams | 47.54 | 15.26 | 32 | 18163 | 10324 | 64470213 |
Nightmare | 46.24 | 15.26 | 42 | 18153 | 20951 | 64459586 |
Major depression | 40.37 | 15.26 | 26 | 18169 | 7790 | 64472747 |
Agitation | 38.29 | 15.26 | 80 | 18115 | 88287 | 64392250 |
Migraine | 36.07 | 15.26 | 64 | 18131 | 62613 | 64417924 |
Feeling jittery | 35.34 | 15.26 | 27 | 18168 | 10608 | 64469929 |
Condition aggravated | 33.42 | 15.26 | 199 | 17996 | 372227 | 64108310 |
Neutropenia | 33.25 | 15.26 | 13 | 18182 | 239611 | 64240926 |
Impaired driving ability | 33.09 | 15.26 | 19 | 18176 | 4635 | 64475902 |
Anaemia | 32.91 | 15.26 | 35 | 18160 | 378645 | 64101892 |
Tinnitus | 32.52 | 15.26 | 44 | 18151 | 34089 | 64446448 |
Mood altered | 31.39 | 15.26 | 30 | 18165 | 15949 | 64464588 |
Mental disorder | 31.35 | 15.26 | 38 | 18157 | 26407 | 64454130 |
Thrombocytopenia | 31.28 | 15.26 | 12 | 18183 | 223789 | 64256748 |
Mania | 30.90 | 15.26 | 30 | 18165 | 16256 | 64464281 |
Paranoia | 30.80 | 15.26 | 30 | 18165 | 16322 | 64464215 |
Pre-existing condition improved | 30.07 | 15.26 | 18 | 18177 | 4744 | 64475793 |
Febrile neutropenia | 29.88 | 15.26 | 8 | 18187 | 187649 | 64292888 |
Seizure | 29.69 | 15.26 | 109 | 18086 | 166783 | 64313754 |
Disturbance in attention | 29.04 | 15.26 | 46 | 18149 | 41028 | 64439509 |
Prescribed overdose | 28.77 | 15.26 | 32 | 18163 | 20299 | 64460238 |
Abnormal behaviour | 28.53 | 15.26 | 41 | 18154 | 33581 | 64446956 |
General physical health deterioration | 28.50 | 15.26 | 11 | 18184 | 204414 | 64276123 |
Schizophreniform disorder | 28.40 | 15.26 | 7 | 18188 | 152 | 64480385 |
Sepsis | 28.06 | 15.26 | 15 | 18180 | 230326 | 64250211 |
Panic reaction | 27.46 | 15.26 | 16 | 18179 | 4011 | 64476526 |
Hostility | 27.13 | 15.26 | 13 | 18182 | 2194 | 64478343 |
Pyrexia | 26.35 | 15.26 | 76 | 18119 | 558568 | 63921969 |
Mood swings | 25.59 | 15.26 | 28 | 18167 | 17440 | 64463097 |
Therapeutic response unexpected | 24.47 | 15.26 | 27 | 18168 | 16974 | 64463563 |
Suicidal behaviour | 23.83 | 15.26 | 13 | 18182 | 2874 | 64477663 |
Reversible cerebral vasoconstriction syndrome | 23.46 | 15.26 | 12 | 18183 | 2330 | 64478207 |
Paraesthesia | 22.37 | 15.26 | 86 | 18109 | 134436 | 64346101 |
Bipolar disorder | 22.10 | 15.26 | 17 | 18178 | 6744 | 64473793 |
Hypersensitivity vasculitis | 22.10 | 15.26 | 17 | 18178 | 6744 | 64473793 |
Affect lability | 21.81 | 15.26 | 19 | 18176 | 8971 | 64471566 |
Tardive dyskinesia | 21.47 | 15.26 | 19 | 18176 | 9159 | 64471378 |
Frustration tolerance decreased | 21.35 | 15.26 | 16 | 18179 | 6109 | 64474428 |
Renal impairment | 21.03 | 15.26 | 6 | 18189 | 135011 | 64345526 |
Stress | 20.82 | 15.26 | 50 | 18145 | 60484 | 64420053 |
Dissociation | 20.63 | 15.26 | 12 | 18183 | 2999 | 64477538 |
Renal failure | 20.46 | 15.26 | 13 | 18182 | 181675 | 64298862 |
Drug dependence | 20.44 | 15.26 | 35 | 18160 | 33277 | 64447260 |
Amnesia | 20.09 | 15.26 | 43 | 18152 | 48226 | 64432311 |
Palpitations | 20.07 | 15.26 | 70 | 18125 | 104418 | 64376119 |
Drug screen positive | 20.04 | 15.26 | 15 | 18180 | 5714 | 64474823 |
Self-injurious ideation | 19.96 | 15.26 | 12 | 18183 | 3185 | 64477352 |
Road traffic accident | 19.79 | 15.26 | 33 | 18162 | 30712 | 64449825 |
Memory impairment | 19.68 | 15.26 | 61 | 18134 | 85621 | 64394916 |
Hypersomnia | 19.67 | 15.26 | 26 | 18169 | 19691 | 64460846 |
Malaise | 19.63 | 15.26 | 184 | 18011 | 396063 | 64084474 |
Malignant neoplasm progression | 19.56 | 15.26 | 4 | 18191 | 112867 | 64367670 |
Change in seizure presentation | 19.52 | 15.26 | 6 | 18189 | 301 | 64480236 |
Dyspnoea | 19.47 | 15.26 | 121 | 18074 | 718553 | 63761984 |
Energy increased | 18.92 | 15.26 | 11 | 18184 | 2747 | 64477790 |
Bradycardia | 18.88 | 15.26 | 5 | 18190 | 118214 | 64362323 |
Multiple organ dysfunction syndrome | 18.86 | 15.26 | 3 | 18192 | 101410 | 64379127 |
Product dose omission issue | 18.68 | 15.26 | 106 | 18089 | 194641 | 64285896 |
Mental impairment | 18.59 | 15.26 | 23 | 18172 | 16320 | 64464217 |
Bruxism | 18.58 | 15.26 | 12 | 18183 | 3612 | 64476925 |
Drug effective for unapproved indication | 18.33 | 15.26 | 12 | 18183 | 3696 | 64476841 |
Contraindicated product administered | 18.32 | 15.26 | 4 | 18191 | 107825 | 64372712 |
Impaired work ability | 18.25 | 15.26 | 22 | 18173 | 15197 | 64465340 |
Death | 17.77 | 15.26 | 73 | 18122 | 482632 | 63997905 |
Dry mouth | 17.74 | 15.26 | 47 | 18148 | 60371 | 64420166 |
Septic shock | 17.74 | 15.26 | 4 | 18191 | 105433 | 64375104 |
Muscle twitching | 17.35 | 15.26 | 24 | 18171 | 18974 | 64461563 |
Somnolence | 17.06 | 15.26 | 107 | 18088 | 203538 | 64276999 |
Wernicke-Korsakoff syndrome | 17.04 | 15.26 | 4 | 18191 | 70 | 64480467 |
Ankyloglossia congenital | 16.70 | 15.26 | 3 | 18192 | 12 | 64480525 |
Intestinal pseudo-obstruction | 16.49 | 15.26 | 9 | 18186 | 1991 | 64478546 |
Brain injury | 16.41 | 15.26 | 17 | 18178 | 9948 | 64470589 |
Synovitis | 16.19 | 15.26 | 4 | 18191 | 99086 | 64381451 |
Anorgasmia | 16.12 | 15.26 | 7 | 18188 | 942 | 64479595 |
Illness | 16.10 | 15.26 | 25 | 18170 | 21913 | 64458624 |
Vision blurred | 16.05 | 15.26 | 59 | 18136 | 90257 | 64390280 |
Paralysis | 15.97 | 15.26 | 18 | 18177 | 11577 | 64468960 |
Insulinoma | 15.89 | 15.26 | 4 | 18191 | 95 | 64480442 |
Therapeutic response changed | 15.87 | 15.26 | 7 | 18188 | 977 | 64479560 |
Hypotension | 15.70 | 15.26 | 55 | 18140 | 380919 | 64099618 |
Aggression | 15.70 | 15.26 | 38 | 18157 | 46194 | 64434343 |
Vertigo | 15.43 | 15.26 | 44 | 18151 | 58967 | 64421570 |
None
Source | Code | Description |
---|---|---|
ATC | N06AX23 | NERVOUS SYSTEM PSYCHOANALEPTICS ANTIDEPRESSANTS Other antidepressants |
FDA MoA | N0000000102 | Norepinephrine Uptake Inhibitors |
FDA MoA | N0000000109 | Serotonin Uptake Inhibitors |
MeSH PA | D000928 | Antidepressive Agents |
MeSH PA | D002491 | Central Nervous System Agents |
MeSH PA | D049990 | Membrane Transport Modulators |
MeSH PA | D018377 | Neurotransmitter Agents |
MeSH PA | D014179 | Neurotransmitter Uptake Inhibitors |
MeSH PA | D011619 | Psychotropic Drugs |
MeSH PA | D000068760 | Serotonin and Noradrenaline Reuptake Inhibitors |
FDA EPC | N0000175749 | Serotonin and Norepinephrine Reuptake Inhibitor |
FDA MoA | N0000182137 | Cytochrome P450 2D6 Inhibitors |
CHEBI has role | CHEBI:35469 | antidepressants |
CHEBI has role | CHEBI:49103 | drug metabolites |
CHEBI has role | CHEBI:83399 | marine xenobiotic metabolites |
Disease | Relation | SNOMED_ID | DOID |
---|---|---|---|
Major depressive disorder | indication | 370143000 | |
Generalized anxiety disorder | off-label use | 21897009 | DOID:14320 |
Social phobia | off-label use | 25501002 | DOID:11257 |
Menopausal flushing | off-label use | 198436008 | |
Neuropathic pain | off-label use | 247398009 | |
Panic disorder | off-label use | 371631005 | DOID:594 |
Ocular hypertension | contraindication | 4210003 | DOID:9282 |
Suicidal thoughts | contraindication | 6471006 | |
Hypercholesterolemia | contraindication | 13644009 | |
Bipolar disorder | contraindication | 13746004 | DOID:3312 |
Neuroleptic malignant syndrome | contraindication | 15244003 | DOID:14464 |
Hypertensive disorder | contraindication | 38341003 | DOID:10763 |
Disorder of cardiovascular system | contraindication | 49601007 | DOID:1287 |
Syndrome of inappropriate vasopressin secretion | contraindication | 55004003 | DOID:3401 |
Cerebrovascular disease | contraindication | 62914000 | DOID:6713 |
Blood coagulation disorder | contraindication | 64779008 | DOID:1247 |
Hyponatremia | contraindication | 89627008 | |
Seizure disorder | contraindication | 128613002 | |
Bleeding | contraindication | 131148009 | |
Impaired renal function disorder | contraindication | 197663003 | |
Mania | contraindication | 231494001 | |
Hypomania | contraindication | 231496004 | |
Interstitial lung disease | contraindication | 233703007 | DOID:3082 |
Disease of liver | contraindication | 235856003 | DOID:409 |
Hypertriglyceridemia | contraindication | 302870006 | |
Serotonin syndrome | contraindication | 371089000 | |
Angle-closure glaucoma | contraindication | 392291006 | DOID:13550 |
Myocardial infarction in recovery phase | contraindication | 418044006 | |
Hypertensive urgency | contraindication | 443482000 |
None
None
Dissociation level | Dissociation constant | Type (acidic/basic) |
---|---|---|
pKa1 | 10.79 | acidic |
pKa2 | 9.33 | Basic |
Formulation strength | Trade name | Applicant | Application number | Approval date | Type | Dose form | Route | Patent number | Patent expiration date | Patent use |
---|---|---|---|---|---|---|---|---|---|---|
EQ 100MG BASE | PRISTIQ | PF PRISM CV | N021992 | Feb. 29, 2008 | RX | TABLET, EXTENDED RELEASE | ORAL | 6673838 | March 1, 2022 | FOR THE APPROVED USES AND CONDITIONS OF USE, INCLUDING DEPRESSION |
EQ 100MG BASE | PRISTIQ | PF PRISM CV | N021992 | Feb. 29, 2008 | RX | TABLET, EXTENDED RELEASE | ORAL | 6673838 | March 1, 2022 | MAINTENANCE TREATMENT OF MAJOR DEPRESSIVE DISORDER (MDD) |
EQ 25MG BASE | PRISTIQ | PF PRISM CV | N021992 | Aug. 20, 2014 | RX | TABLET, EXTENDED RELEASE | ORAL | 6673838 | March 1, 2022 | FOR THE APPROVED USES AND CONDITIONS OF USE, INCLUDING DEPRESSION |
EQ 25MG BASE | PRISTIQ | PF PRISM CV | N021992 | Aug. 20, 2014 | RX | TABLET, EXTENDED RELEASE | ORAL | 6673838 | March 1, 2022 | MAINTENANCE TREATMENT OF MAJOR DEPRESSIVE DISORDER (MDD) |
EQ 50MG BASE | PRISTIQ | PF PRISM CV | N021992 | Feb. 29, 2008 | RX | TABLET, EXTENDED RELEASE | ORAL | 6673838 | March 1, 2022 | FOR THE APPROVED USES AND CONDITIONS OF USE, INCLUDING DEPRESSION |
EQ 50MG BASE | PRISTIQ | PF PRISM CV | N021992 | Feb. 29, 2008 | RX | TABLET, EXTENDED RELEASE | ORAL | 6673838 | March 1, 2022 | MAINTENANCE TREATMENT OF MAJOR DEPRESSIVE DISORDER (MDD) |
None
Target | Class | Pharos | UniProt | Action | Type | Activity value (-log[M]) | Mechanism action | Bioact source | MoA source |
---|---|---|---|---|---|---|---|---|---|
Sodium-dependent serotonin transporter | Transporter | INHIBITOR | Ki | 7.33 | WOMBAT-PK | CHEMBL | |||
Sodium-dependent noradrenaline transporter | Transporter | INHIBITOR | Ki | 6.28 | WOMBAT-PK | CHEMBL | |||
Alpha-1A adrenergic receptor | GPCR | IC50 | 7.22 | CHEMBL |
ID | Source |
---|---|
D07793 | KEGG_DRUG |
4027338 | VUID |
N0000176142 | NUI |
386750-22-7 | SECONDARY_CAS_RN |
93414-04-1 | SECONDARY_CAS_RN |
4027338 | VANDF |
C1880288 | UMLSCUI |
CHEBI:83527 | CHEBI |
CHEMBL1118 | ChEMBL_ID |
CHEMBL1201728 | ChEMBL_ID |
DB06700 | DRUGBANK_ID |
7158 | IUPHAR_LIGAND_ID |
8361 | INN_ID |
NG99554ANW | UNII |
125017 | PUBCHEM_CID |
683693 | RXNORM |
132507 | MMSL |
200628 | MMSL |
25184 | MMSL |
339716 | MMSL |
38906 | MMSL |
d07113 | MMSL |
012574 | NDDF |
012575 | NDDF |
015249 | NDDF |
430267008 | SNOMEDCT_US |
430271006 | SNOMEDCT_US |
433292007 | SNOMEDCT_US |
D000069468 | MESH_DESCRIPTOR_UI |
CHEMBL3989861 | ChEMBL_ID |
Product | Category | Ingredients | NDC | Form | Quantity | Route | Marketing | Label |
---|---|---|---|---|---|---|---|---|
Pristiq Extended-Release | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0008-1210 | TABLET, EXTENDED RELEASE | 25 mg | ORAL | NDA | 31 sections |
Pristiq Extended-Release | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0008-1210 | TABLET, EXTENDED RELEASE | 25 mg | ORAL | NDA | 31 sections |
Pristiq Extended-Release | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0008-1211 | TABLET, EXTENDED RELEASE | 50 mg | ORAL | NDA | 31 sections |
Pristiq Extended-Release | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0008-1211 | TABLET, EXTENDED RELEASE | 50 mg | ORAL | NDA | 31 sections |
Pristiq Extended-Release | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0008-1222 | TABLET, EXTENDED RELEASE | 100 mg | ORAL | NDA | 31 sections |
Pristiq Extended-Release | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0008-1222 | TABLET, EXTENDED RELEASE | 100 mg | ORAL | NDA | 31 sections |
Desvenlafaxine | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0054-0400 | TABLET, FILM COATED, EXTENDED RELEASE | 50 mg | ORAL | ANDA | 30 sections |
Desvenlafaxine | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0054-0401 | TABLET, FILM COATED, EXTENDED RELEASE | 100 mg | ORAL | ANDA | 30 sections |
Desvenlafaxine | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0054-0603 | TABLET, FILM COATED, EXTENDED RELEASE | 25 mg | ORAL | ANDA | 30 sections |
Desvenlafaxine | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0591-3659 | TABLET, EXTENDED RELEASE | 50 mg | ORAL | ANDA | 30 sections |
Desvenlafaxine | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0591-3659 | TABLET, EXTENDED RELEASE | 50 mg | ORAL | ANDA | 30 sections |
Desvenlafaxine | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0591-3660 | TABLET, EXTENDED RELEASE | 100 mg | ORAL | ANDA | 30 sections |
Desvenlafaxine | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0591-3660 | TABLET, EXTENDED RELEASE | 100 mg | ORAL | ANDA | 30 sections |
Desvenlafaxine | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0591-4060 | TABLET, EXTENDED RELEASE | 25 mg | ORAL | ANDA | 30 sections |
Desvenlafaxine | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0591-4060 | TABLET, EXTENDED RELEASE | 25 mg | ORAL | ANDA | 30 sections |
Desvenlafaxine | Human Prescription Drug Label | 1 | 35208-009 | TABLET, EXTENDED RELEASE | 50 mg | ORAL | ANDA | 30 sections |
Desvenlafaxine | Human Prescription Drug Label | 1 | 35208-010 | TABLET, EXTENDED RELEASE | 100 mg | ORAL | ANDA | 30 sections |
PristiqExtended-Release | HUMAN PRESCRIPTION DRUG LABEL | 1 | 43063-262 | TABLET, EXTENDED RELEASE | 50 mg | ORAL | NDA | 31 sections |
Desvenlafaxine | Human Prescription Drug Label | 1 | 46708-152 | TABLET, EXTENDED RELEASE | 50 mg | ORAL | NDA | 30 sections |
Desvenlafaxine | Human Prescription Drug Label | 1 | 46708-153 | TABLET, EXTENDED RELEASE | 100 mg | ORAL | NDA | 30 sections |
Desvenlafaxine | Human Prescription Drug Label | 1 | 46708-540 | TABLET, EXTENDED RELEASE | 50 mg | ORAL | ANDA | 30 sections |
Desvenlafaxine | Human Prescription Drug Label | 1 | 46708-541 | TABLET, EXTENDED RELEASE | 100 mg | ORAL | ANDA | 30 sections |
Desvenlafaxine | Human Prescription Drug Label | 1 | 46708-542 | TABLET, EXTENDED RELEASE | 25 mg | ORAL | ANDA | 30 sections |
Desvenlafaxine Succinate | HUMAN PRESCRIPTION DRUG LABEL | 1 | 50090-4069 | TABLET, EXTENDED RELEASE | 50 mg | ORAL | NDA AUTHORIZED GENERIC | 30 sections |
Desvenlafaxine | HUMAN PRESCRIPTION DRUG LABEL | 1 | 50090-4388 | TABLET, EXTENDED RELEASE | 25 mg | ORAL | ANDA | 30 sections |
Desvenlafaxine | HUMAN PRESCRIPTION DRUG LABEL | 1 | 50090-4806 | TABLET, FILM COATED, EXTENDED RELEASE | 50 mg | ORAL | ANDA | 30 sections |
Desvenlafaxine | Human Prescription Drug Label | 1 | 50090-5274 | TABLET, EXTENDED RELEASE | 25 mg | ORAL | ANDA | 30 sections |
Desvenlafaxine | Human Prescription Drug Label | 1 | 50090-5293 | TABLET, EXTENDED RELEASE | 50 mg | ORAL | ANDA | 30 sections |
Desvenlafaxine | HUMAN PRESCRIPTION DRUG LABEL | 1 | 51407-021 | TABLET, EXTENDED RELEASE | 25 mg | ORAL | ANDA | 30 sections |
Desvenlafaxine | HUMAN PRESCRIPTION DRUG LABEL | 1 | 51407-022 | TABLET, EXTENDED RELEASE | 50 mg | ORAL | ANDA | 30 sections |