All FDA-approved EMA-approved PMDA-approved
Target Card Uniprot Example: P23975

busulfan 🐶 Veterinary Use | Indications/Contra | FAERs-F | FAERs-M | Orange Bk | BioActivity |

Stem definition	Drug id	CAS RN
antineoplastic, alkylating agents, methanesulfonates	438	55-98-1

Description:

Molecule

Description

Molfile Inchi Smiles Synonyms: busilvex busulfan busulfex busulphan citosulfan glyzophrol leucosulfan sulphabutin

An alkylating agent having a selective immunosuppressive effect on BONE MARROW. It has been used in the palliative treatment of chronic myeloid leukemia (MYELOID LEUKEMIA, CHRONIC), but although symptomatic relief is provided, no permanent remission is brought about. According to the Fourth Annual Report on Carcinogens (NTP 85-002, 1985), busulfan is listed as a known carcinogen. Molecular weight: 246.29 Formula: C6H14O6S2 CLOGP: -0.59 LIPINSKI: 0 HAC: 6 HDO: 0 TPSA: 86.74 ALOGS: -1.68 ROTB: 7 Status: OFP Legend: OFP - off patent OFM - off market ONP - on patent

Drug dosage:

None

ADMET properties:

Property	Value	Reference
BDDCS (Biopharmaceutical Drug Disposition Classification System)	1	Benet LZ, Broccatelli F, Oprea TI
S (Water solubility)	0.03 mg/mL	Bocci G, Oprea TI, Benet LZ
EoM (Fraction excreted unchanged in urine)	1 %	Benet LZ, Broccatelli F, Oprea TI
MRTD (Maximum Recommended Therapeutic Daily Dose)	0.23 µM/kg/day	Contrera JF, Matthews EJ, Kruhlak NL, Benz RD
BA (Bioavailability)	70 %	Kim MT, Sedykh A, Chakravarti SK, Saiakhov RD, Zhu H
Vd (Volume of distribution)	0.55 L/kg	Lombardo F, Berellini G, Obach RS
CL (Clearance)	2.40 mL/min/kg	Lombardo F, Berellini G, Obach RS
fu (Fraction unbound in plasma)	1 %	Lombardo F, Berellini G, Obach RS
t_half (Half-life)	3.40 hours	Lombardo F, Berellini G, Obach RS

Approvals:

Date	Agency	Company	Orphan
June 26, 1954	FDA	ASPEN GLOBAL
March 25, 2020	PMDA	Otsuka Pharmaceutical Co., Ltd

FDA Adverse Event Reporting System (Female)

MedDRA adverse event term	Likelihood ratio	Likelihood ratio threshold	Patients taking drug having adverse event	Patients taking drug not having adverse event	Patients not taking drug having adverse event	Patients not taking drug not having adverse event
Acute graft versus host disease	1027.57	34.35	232	14540	4196	63470054
Graft versus host disease	855.22	34.35	217	14555	6546	63467704
Chronic graft versus host disease	854.10	34.35	187	14585	2915	63471335
Cytomegalovirus infection	781.00	34.35	260	14512	20692	63453558
Venoocclusive liver disease	756.14	34.35	184	14588	4651	63469599
Acute graft versus host disease in skin	731.40	34.35	168	14604	3284	63470966
Product use in unapproved indication	555.35	34.35	402	14370	178678	63295572
Graft versus host disease in skin	502.66	34.35	120	14652	2785	63471465
Venoocclusive disease	499.85	34.35	112	14660	1946	63472304
Mucosal inflammation	417.23	34.35	208	14564	46720	63427530
Graft versus host disease in gastrointestinal tract	404.56	34.35	103	14669	3138	63471112
Cytomegalovirus viraemia	400.99	34.35	115	14657	5534	63468716
Cystitis haemorrhagic	356.68	34.35	98	14674	4025	63470225
Ovarian failure	349.46	34.35	77	14695	1233	63473017
Acute graft versus host disease in intestine	327.31	34.35	77	14695	1672	63472578
Thrombotic microangiopathy	303.41	34.35	108	14664	10453	63463797
Cytomegalovirus infection reactivation	287.15	34.35	82	14690	3881	63470369
Acute myeloid leukaemia recurrent	229.45	34.35	57	14715	1566	63472684
Transplant failure	210.76	34.35	53	14719	1532	63472718
Premature menopause	208.46	34.35	47	14725	839	63473411
Adenovirus infection	206.33	34.35	62	14710	3509	63470741
Viral haemorrhagic cystitis	198.51	34.35	45	14727	824	63473426
Febrile neutropenia	191.83	34.35	183	14589	118266	63355984
Primary hypogonadism	187.35	34.35	33	14739	146	63474104
Ovarian atrophy	178.06	34.35	29	14743	70	63474180
Post transplant lymphoproliferative disorder	169.65	34.35	58	14714	4973	63469277
Epstein-Barr virus infection	167.55	34.35	65	14707	7985	63466265
BK virus infection	164.17	34.35	51	14721	3228	63471022
Posterior reversible encephalopathy syndrome	148.38	34.35	75	14697	17270	63456980
Acute graft versus host disease in liver	143.86	34.35	33	14739	638	63473612
Human herpesvirus 6 infection	139.71	34.35	44	14728	2913	63471337
Chronic graft versus host disease in skin	134.85	34.35	32	14740	721	63473529
Bacteraemia	131.05	34.35	69	14703	17279	63456971
Blood follicle stimulating hormone increased	130.86	34.35	24	14748	139	63474111
Multiple organ dysfunction syndrome	130.38	34.35	107	14665	56645	63417605
Acute lymphocytic leukaemia recurrent	129.37	34.35	39	14733	2230	63472020
Idiopathic pneumonia syndrome	129.05	34.35	27	14745	333	63473917
Off label use	127.57	34.35	394	14378	674068	62800182
Blood luteinising hormone increased	126.89	34.35	22	14750	87	63474163
Cytomegalovirus chorioretinitis	116.08	34.35	34	14738	1759	63472491
Aplastic anaemia	104.78	34.35	49	14723	9520	63464730
Thrombocytopenia	101.73	34.35	149	14623	151008	63323242
Systemic mycosis	101.40	34.35	28	14744	1169	63473081
Mucormycosis	100.32	34.35	34	14738	2837	63471413
Pulmonary haemorrhage	98.39	34.35	43	14729	7138	63467112
Upper respiratory fungal infection	97.50	34.35	19	14753	159	63474091
Pain	92.34	34.35	29	14743	740599	62733651
Haemophagocytic lymphohistiocytosis	91.01	34.35	46	14726	10581	63463669
Cytomegalovirus test positive	90.95	34.35	32	14740	2986	63471264
Acute myeloid leukaemia	90.76	34.35	54	14718	17093	63457157
Bacterial sepsis	89.66	34.35	34	14738	3924	63470326
Fatigue	87.95	34.35	49	14723	887979	62586271
Cystitis viral	87.05	34.35	17	14755	144	63474106
Leukaemia recurrent	84.98	34.35	25	14747	1313	63472937
Graft versus host disease in lung	83.03	34.35	19	14753	363	63473887
Neurotoxicity	78.37	34.35	49	14723	16941	63457309
Arthralgia	77.09	34.35	19	14753	569691	62904559
Transplant dysfunction	76.06	34.35	32	14740	4840	63469410
Bone marrow failure	75.25	34.35	59	14713	29231	63445019
Dizziness	74.71	34.35	7	14765	429918	63044332
Alternaria infection	73.88	34.35	16	14756	235	63474015
Epstein-Barr virus infection reactivation	73.79	34.35	20	14752	778	63473472
Toxoplasmosis	73.35	34.35	23	14749	1500	63472750
Headache	71.68	34.35	29	14743	633212	62841038
Neutropenia	70.26	34.35	137	14635	174868	63299382
Bronchopulmonary aspergillosis	69.94	34.35	36	14736	8599	63465651
Disseminated mucormycosis	66.66	34.35	14	14758	176	63474074
Fall	66.55	34.35	7	14765	392327	63081923
Adenoviral hepatitis	66.41	34.35	16	14756	385	63473865
Obliterative bronchiolitis	66.15	34.35	23	14749	2072	63472178
Encephalitis cytomegalovirus	65.92	34.35	17	14755	544	63473706
Respiratory failure	65	34.35	98	14674	101760	63372490
Pain in extremity	64.57	34.35	3	14769	331483	63142767
Laryngitis fungal	64.27	34.35	13	14759	134	63474116
Aspergillus infection	63.42	34.35	33	14739	8060	63466190
Nodular melanoma	62.02	34.35	11	14761	51	63474199
Neoplasm recurrence	60.97	34.35	23	14749	2615	63471635
Acute respiratory distress syndrome	59.58	34.35	47	14725	23487	63450763
JC virus infection	58.96	34.35	21	14751	2030	63472220
Pulmonary veno-occlusive disease	58.49	34.35	18	14754	1103	63473147
Ascites	58.46	34.35	59	14713	40669	63433581
Drug hypersensitivity	56.87	34.35	4	14768	310683	63163567
Hepatomegaly	56.63	34.35	35	14737	11854	63462396
Epstein-Barr viraemia	56.03	34.35	17	14755	993	63473257
Bone marrow transplant rejection	53.94	34.35	10	14762	62	63474188
Pancytopenia	53.15	34.35	87	14685	96846	63377404
Hypersensitivity	52.90	34.35	4	14768	292681	63181569
Engraft failure	52.46	34.35	13	14759	353	63473897
Drug resistance	52.11	34.35	43	14729	22890	63451360
Citrobacter bacteraemia	49.82	34.35	8	14764	17	63474233
Staphylococcal sepsis	49.38	34.35	28	14744	8100	63466150
Human polyomavirus infection	48.70	34.35	12	14760	318	63473932
Drug intolerance	48.66	34.35	7	14765	308654	63165596
Recurrent cancer	48.39	34.35	18	14754	1969	63472281
Alopecia	48.09	34.35	10	14762	337526	63136724
Cytomegalovirus urinary tract infection	47.72	34.35	9	14763	62	63474188
Staphylococcal infection	47.22	34.35	53	14719	41203	63433047
Septic shock	46.66	34.35	67	14705	66562	63407688
Back pain	46.64	34.35	4	14768	264141	63210109
Progressive multifocal leukoencephalopathy	46.60	34.35	32	14740	12939	63461311
Stem cell transplant	46.19	34.35	17	14755	1805	63472445
Autoimmune haemolytic anaemia	45.59	34.35	22	14750	4579	63469671
Pyrexia	45.58	34.35	223	14549	470255	63003995
Sepsis	45.37	34.35	106	14666	153017	63321233
Complications of bone marrow transplant	44.47	34.35	12	14760	459	63473791
Hypogonadism	43.55	34.35	9	14763	104	63474146
Arthropathy	43.01	34.35	3	14769	234789	63239461
Myelosuppression	42.84	34.35	39	14733	23664	63450586
Focal nodular hyperplasia	42.18	34.35	12	14760	559	63473691
Disseminated toxoplasmosis	41.76	34.35	9	14763	129	63474121
Pruritus	41.71	34.35	16	14756	361437	63112813
Myelodysplastic syndrome	41.42	34.35	33	14739	16721	63457529
Haematuria	41.40	34.35	42	14730	29115	63445135
Device related infection	41.33	34.35	38	14734	23354	63450896
Hepatic necrosis	41.18	34.35	22	14750	5665	63468585
Blood stem cell transplant failure	40.54	34.35	9	14763	149	63474101
Maternal exposure during pregnancy	39.77	34.35	3	14769	220059	63254191
Streptococcal bacteraemia	39.29	34.35	15	14757	1762	63472488
Cellulitis staphylococcal	38.98	34.35	12	14760	736	63473514
Lower respiratory tract infection fungal	38.51	34.35	10	14762	329	63473921
Dedifferentiated liposarcoma	38.39	34.35	7	14765	39	63474211
Cardiotoxicity	38.06	34.35	24	14748	8414	63465836
Gastrointestinal toxicity	37.40	34.35	23	14749	7718	63466532
Hilar lymphadenopathy	36.98	34.35	13	14759	1209	63473041
Pericardial effusion	36.79	34.35	40	14732	30018	63444232
Escherichia bacteraemia	36.77	34.35	18	14754	3865	63470385
Pulmonary alveolar haemorrhage	36.47	34.35	19	14753	4649	63469601
Bronchiolitis obliterans syndrome	35.95	34.35	8	14764	134	63474116
Growth retardation	35.80	34.35	13	14759	1328	63472922
Adrenal haemorrhage	35.74	34.35	10	14762	438	63473812
Rash	35.74	34.35	47	14725	560824	62913426
Primary adrenal insufficiency	35.62	34.35	8	14764	140	63474110
Disseminated tuberculosis	35.51	34.35	16	14756	2851	63471399
Candida sepsis	35.44	34.35	13	14759	1367	63472883
Fungaemia	34.91	34.35	15	14757	2388	63471862

FDA Adverse Event Reporting System (Male)

MedDRA adverse event term	Likelihood ratio	Likelihood ratio threshold	Patients taking drug having adverse event	Patients taking drug not having adverse event	Patients not taking drug having adverse event	Patients not taking drug not having adverse event
Acute graft versus host disease	974.59	23.00	288	19414	6215	34931014
Venoocclusive liver disease	933.69	23.00	292	19410	7674	34929555
Graft versus host disease	891.81	23.00	302	19400	10267	34926962
Cytomegalovirus infection	840.70	23.00	370	19332	25765	34911464
Product use in unapproved indication	697.25	23.00	555	19147	116944	34820285
Acute graft versus host disease in skin	661.21	23.00	203	19499	4998	34932231
Mucosal inflammation	596.83	23.00	332	19370	38290	34898939
Venoocclusive disease	582.11	23.00	161	19541	2706	34934523
Chronic graft versus host disease	578.48	23.00	176	19526	4197	34933032
Cystitis haemorrhagic	461.89	23.00	158	19544	5521	34931708
Graft versus host disease in skin	357.79	23.00	119	19583	3806	34933423
Graft versus host disease in gastrointestinal tract	345.06	23.00	114	19588	3569	34933660
Acute graft versus host disease in intestine	303.34	23.00	96	19606	2612	34934617
BK virus infection	295.67	23.00	114	19588	5624	34931605
Epstein-Barr virus infection	277.47	23.00	118	19584	7510	34929719
Thrombotic microangiopathy	267.21	23.00	127	19575	10503	34926726
Cytomegalovirus viraemia	253.99	23.00	110	19592	7320	34929909
Posterior reversible encephalopathy syndrome	250.43	23.00	119	19583	9835	34927394
Acute myeloid leukaemia recurrent	247.49	23.00	78	19624	2092	34935137
Transplant failure	247.09	23.00	88	19614	3465	34933764
Cytomegalovirus infection reactivation	240.08	23.00	95	19607	5023	34932206
Post transplant lymphoproliferative disorder	237.47	23.00	101	19601	6427	34930802
Adenovirus infection	200.08	23.00	84	19618	5173	34932056
Viral haemorrhagic cystitis	179.78	23.00	53	19649	1127	34936102
Febrile neutropenia	168.37	23.00	287	19415	136562	34800667
Multiple organ dysfunction syndrome	144.37	23.00	196	19506	76370	34860859
Bacteraemia	139.91	23.00	104	19598	19613	34917616
End stage renal disease	138.76	23.00	77	19625	8784	34928445
Acute graft versus host disease in liver	136.80	23.00	46	19656	1520	34935709
Herpes simplex	135.33	23.00	65	19637	5494	34931735
Fatigue	131.69	23.00	25	19677	370628	34566601
Bronchopulmonary aspergillosis	126.24	23.00	87	19615	14572	34922657
Chronic graft versus host disease in skin	123.60	23.00	38	19664	936	34936293
Stomatitis	112.40	23.00	129	19573	42385	34894844
Off label use	105.16	23.00	490	19212	419034	34518195
JC virus infection	103.58	23.00	41	19661	2167	34935062
Progressive multifocal leukoencephalopathy	103.56	23.00	66	19636	9698	34927531
Leukaemia recurrent	101.03	23.00	37	19665	1578	34935651
Respiratory failure	94.99	23.00	197	19505	108375	34828854
Epstein-Barr virus infection reactivation	94.73	23.00	32	19670	1072	34936157
Bone marrow failure	93.33	23.00	98	19604	29155	34908074
Aplastic anaemia	91.60	23.00	61	19641	9655	34927574
Pneumonia cytomegaloviral	90.75	23.00	41	19661	3013	34934216
Pancytopenia	89.56	23.00	178	19524	94979	34842250
Haematotoxicity	88.43	23.00	56	19646	8138	34929091
Bone marrow transplant rejection	88.18	23.00	21	19681	186	34937043
Graft versus host disease in liver	86.23	23.00	31	19671	1253	34935976
Engraftment syndrome	85.95	23.00	29	19673	968	34936261
Dizziness	85.91	23.00	11	19691	218510	34718719
Cystitis viral	84.86	23.00	25	19677	530	34936699
Cytomegalovirus test positive	84.29	23.00	42	19660	3844	34933385
Chronic graft versus host disease in liver	80.49	23.00	23	19679	436	34936793
Fall	80.26	23.00	10	19692	202875	34734354
Engraft failure	79.14	23.00	23	19679	464	34936765
Human herpesvirus 6 infection	78.32	23.00	33	19669	2048	34935181
Stenotrophomonas infection	77.88	23.00	33	19669	2077	34935152
Blood follicle stimulating hormone increased	75.03	23.00	18	19684	165	34937064
Dyspnoea	68.61	23.00	67	19635	376715	34560514
Arthralgia	68.17	23.00	8	19694	170033	34767196
Pulmonary haemorrhage	63.50	23.00	50	19652	10254	34926975
Idiopathic pneumonia syndrome	63.33	23.00	17	19685	253	34936976
Autoimmune haemolytic anaemia	62.10	23.00	36	19666	4460	34932769
Obliterative bronchiolitis	61.34	23.00	24	19678	1229	34936000
Epstein-Barr virus associated lymphoproliferative disorder	60.37	23.00	27	19675	1937	34935292
Asthenia	59.69	23.00	32	19670	245219	34692010
Chronic graft versus host disease in intestine	59.06	23.00	16	19686	247	34936982
Human herpesvirus 6 encephalitis	58.26	23.00	17	19685	348	34936881
Blood luteinising hormone increased	58.05	23.00	13	19689	85	34937144
Acute myeloid leukaemia	57.88	23.00	61	19641	18209	34919020
Autoimmune lymphoproliferative syndrome	56.21	23.00	14	19688	152	34937077
Product dose omission issue	55.24	23.00	3	19699	119708	34817521
Skin toxicity	54.89	23.00	34	19668	4750	34932479
Epstein-Barr viraemia	53.39	23.00	22	19680	1290	34935939
Meningitis tuberculous	51.55	23.00	18	19684	667	34936562
Acute respiratory distress syndrome	51.16	23.00	68	19634	25901	34911328
Encephalitis	48.51	23.00	37	19665	7240	34929989
Death	47.28	23.00	96	19606	397953	34539276
Constipation	46.88	23.00	10	19692	136972	34800257
Toxoplasmosis	46.64	23.00	20	19682	1296	34935933
Polyomavirus viraemia	45.91	23.00	18	19684	927	34936302
Weight decreased	44.35	23.00	22	19680	176279	34760950
Candida infection	43.84	23.00	52	19650	17663	34919566
Cardiotoxicity	42.76	23.00	31	19671	5617	34931612
Haemophagocytic lymphohistiocytosis	42.31	23.00	44	19658	12929	34924300
Complications of bone marrow transplant	41.92	23.00	12	19690	229	34937000
Cerebral toxoplasmosis	41.50	23.00	20	19682	1701	34935528
Mucormycosis	41.35	23.00	31	19671	5911	34931318
Gastrointestinal toxicity	40.84	23.00	23	19679	2696	34934533
Hepatic failure	40.42	23.00	71	19631	34460	34902769
Poikiloderma	40.41	23.00	11	19691	173	34937056
Chloroma	40.27	23.00	14	19688	512	34936717
Stem cell transplant	40.23	23.00	21	19681	2118	34935111
Blood bilirubin increased	40.07	23.00	75	19627	38221	34899008
Enterococcal bacteraemia	39.66	23.00	20	19682	1877	34935352
Anxiety	39.02	23.00	5	19697	99423	34837806
Ascites	38.88	23.00	83	19619	46488	34890741
Pruritus	38.37	23.00	16	19686	141965	34795264
Chest pain	38.13	23.00	12	19690	126750	34810479
Sepsis	38.07	23.00	190	19512	166371	34770858
Tooth development disorder	38.03	23.00	7	19695	13	34937216
Pain in extremity	38.01	23.00	12	19690	126501	34810728
Infection reactivation	37.93	23.00	18	19684	1480	34935749
Cytopenia	37.69	23.00	41	19661	12682	34924547
Myocardial infarction	37.25	23.00	11	19691	121074	34816155
Aspergillus infection	37.19	23.00	40	19662	12214	34925015
Overdose	37.17	23.00	4	19698	91055	34846174
Bone marrow transplant	37.09	23.00	16	19686	1052	34936177
Pulmonary alveolar haemorrhage	36.98	23.00	32	19670	7480	34929749
Gastrointestinal mucosal disorder	36.53	23.00	12	19690	368	34936861
Diffuse alveolar damage	35.92	23.00	20	19682	2294	34934935
Blood pressure increased	35.63	23.00	4	19698	88098	34849131
Lactobacillus infection	34.89	23.00	11	19691	295	34936934
Chronic myeloid leukaemia recurrent	34.77	23.00	10	19692	194	34937035
Varicella zoster virus infection	34.73	23.00	18	19684	1788	34935441
Transplant rejection	33.68	23.00	35	19667	10276	34926953
Depression	33.39	23.00	7	19695	97091	34840138
Eccrine squamous syringometaplasia	32.85	23.00	7	19695	35	34937194
Insomnia	32.77	23.00	9	19693	103898	34833331
Graft versus host disease in eye	32.61	23.00	10	19692	244	34936985
Malaise	32.61	23.00	34	19668	185791	34751438
Pathogen resistance	32.44	23.00	33	19669	9449	34927780
Portal hypertension	32.37	23.00	23	19679	4039	34933190
Retinopathy haemorrhagic	32.07	23.00	7	19695	40	34937189
Evans syndrome	32.01	23.00	10	19692	260	34936969
Septic shock	31.91	23.00	101	19601	71733	34865496
Reticulocytosis	31.65	23.00	10	19692	270	34936959
Myalgia	31.20	23.00	5	19697	84105	34853124
Hepatic vein occlusion	31.18	23.00	9	19693	177	34937052
Pain	31.06	23.00	42	19660	204633	34732596
Back pain	30.90	23.00	15	19687	121774	34815455
Rash	30.59	23.00	49	19653	222703	34714526
Dehydration	30.07	23.00	18	19684	129951	34807278
Hyperfibrinogenaemia	29.92	23.00	7	19695	57	34937172
Pyrexia	29.19	23.00	301	19401	332712	34604517
Dysbiosis	29.09	23.00	11	19691	513	34936716
Pneumocystis jirovecii pneumonia	29.09	23.00	45	19657	19665	34917564
Primary hypogonadism	28.45	23.00	7	19695	72	34937157
Haptoglobin decreased	28.34	23.00	11	19691	551	34936678
Thrombocytopenia	28.09	23.00	167	19535	156080	34781149
Pseudomonal sepsis	28.07	23.00	20	19682	3527	34933702
Drug interaction	28.03	23.00	53	19649	225893	34711336
Adenomatous polyposis coli	27.98	23.00	8	19694	152	34937077
Stenotrophomonas bacteraemia	27.94	23.00	7	19695	78	34937151
Acanthamoeba infection	27.70	23.00	10	19692	409	34936820
Device related bacteraemia	27.54	23.00	10	19692	416	34936813
Encephalitis cytomegalovirus	27.33	23.00	11	19691	607	34936622
Enterobacter sepsis	27.21	23.00	12	19690	832	34936397
Hypogammaglobulinaemia	26.59	23.00	27	19675	7713	34929516
Neurological decompensation	26.46	23.00	18	19684	2948	34934281
Lymphadenopathy	26.42	23.00	53	19649	28410	34908819
Staphylococcal bacteraemia	26.37	23.00	28	19674	8424	34928805
Second primary malignancy	26.17	23.00	27	19675	7859	34929370
Acute lymphocytic leukaemia recurrent	26.03	23.00	18	19684	3026	34934203
Coombs direct test positive	26.02	23.00	9	19693	324	34936905
Hypodontia	25.93	23.00	4	19698	0	34937229
Myelodysplastic syndrome	25.79	23.00	42	19660	19166	34918063
Respiratory distress	25.76	23.00	60	19642	35605	34901624
Gait disturbance	25.70	23.00	8	19694	85132	34852097
Cerebrovascular accident	25.54	23.00	8	19694	84803	34852426
Neurotoxicity	25.03	23.00	40	19662	17970	34919259
Pneumonia fungal	24.82	23.00	25	19677	7075	34930154
Urticaria	24.80	23.00	3	19699	62374	34874855
Graft versus host disease in lung	24.47	23.00	10	19692	574	34936655
Pericardial effusion	24.19	23.00	47	19655	24615	34912614
Anti-platelet antibody positive	24.09	23.00	8	19694	254	34936975
Meningioma	23.91	23.00	13	19689	1423	34935806
Condition aggravated	23.90	23.00	45	19657	192151	34745078
Blood bilirubin unconjugated increased	23.89	23.00	10	19692	610	34936619
Staphylococcal infection	23.53	23.00	55	19647	32705	34904524
Abdominal discomfort	23.49	23.00	3	19699	59832	34877397
Urinary bladder toxicity	23.47	23.00	5	19697	25	34937204
Refractoriness to platelet transfusion	23.32	23.00	6	19696	75	34937154
Hypotension	23.32	23.00	57	19645	221592	34715637
Hepatomegaly	23.25	23.00	29	19673	10367	34926862
Platelet transfusion	23.17	23.00	13	19689	1513	34935716
Cardiac failure congestive	23.11	23.00	9	19693	83261	34853968
Disseminated toxoplasmosis	23.10	23.00	6	19696	78	34937151

FDA Adverse Event Reporting System (Geriatric)

MedDRA adverse event term	Likelihood ratio	Likelihood ratio threshold	Patients taking drug having adverse event	Patients taking drug not having adverse event	Patients not taking drug having adverse event	Patients not taking drug not having adverse event
Venoocclusive liver disease	1879.56	25.29	513	32828	11258	79699789
Acute graft versus host disease	1877.37	25.29	497	32844	9670	79701377
Graft versus host disease	1729.18	25.29	507	32834	14519	79696528
Cytomegalovirus infection	1668.08	25.29	638	32703	42006	79669041
Product use in unapproved indication	1373.74	25.29	1000	32341	249359	79461688
Chronic graft versus host disease	1349.85	25.29	352	32989	6429	79704618
Acute graft versus host disease in skin	1241.74	25.29	338	33003	7320	79703727
Mucosal inflammation	1097.27	25.29	564	32777	75016	79636031
Venoocclusive disease	922.57	25.29	240	33101	4333	79706714
Cystitis haemorrhagic	803.27	25.29	251	33090	8921	79702126
Graft versus host disease in skin	764.85	25.29	220	33121	5853	79705194
Graft versus host disease in gastrointestinal tract	671.76	25.29	201	33140	6155	79704892
Acute graft versus host disease in intestine	570.18	25.29	160	33181	3881	79707166
Cytomegalovirus viraemia	551.62	25.29	206	33135	12615	79698432
Thrombotic microangiopathy	523.04	25.29	225	33116	19944	79691103
Cytomegalovirus infection reactivation	514.39	25.29	177	33164	8539	79702508
Post transplant lymphoproliferative disorder	470.64	25.29	178	33163	11286	79699761
BK virus infection	462.73	25.29	164	33177	8640	79702407
Epstein-Barr virus infection	451.53	25.29	184	33157	14232	79696815
Acute myeloid leukaemia recurrent	450.33	25.29	128	33213	3255	79707792
Adenovirus infection	386.38	25.29	142	33199	8305	79702742
Posterior reversible encephalopathy syndrome	357.31	25.29	188	33153	26093	79684954
Viral haemorrhagic cystitis	352.75	25.29	95	33246	1966	79709081
Transplant failure	348.41	25.29	113	33228	4528	79706519
Febrile neutropenia	336.32	25.29	447	32894	230552	79480495
Acute graft versus host disease in liver	279.25	25.29	78	33263	1857	79709190
Bacteraemia	271.93	25.29	170	33171	32654	79678393
Multiple organ dysfunction syndrome	267.57	25.29	289	33052	119957	79591090
Chronic graft versus host disease in skin	257.41	25.29	70	33271	1504	79709543
Ovarian failure	229.97	25.29	54	33287	622	79710425
Herpes simplex	220.97	25.29	106	33235	12081	79698966
Off label use	216.90	25.29	848	32493	906367	78804680
Fatigue	198.53	25.29	71	33270	929656	78781391
Aplastic anaemia	187.90	25.29	108	33233	17797	79693250
Pancytopenia	186.59	25.29	284	33057	165461	79545586
Leukaemia recurrent	185.91	25.29	62	33279	2712	79708335
Cystitis viral	185.17	25.29	46	33295	682	79710365
Premature menopause	182.06	25.29	44	33297	578	79710469
Human herpesvirus 6 infection	180.01	25.29	72	33269	5298	79705749
Blood follicle stimulating hormone increased	179.90	25.29	39	33302	303	79710744
Idiopathic pneumonia syndrome	178.76	25.29	43	33298	553	79710494
Blood luteinising hormone increased	168.55	25.29	34	33307	177	79710870
Ovarian atrophy	162.26	25.29	29	33312	66	79710981
Dizziness	160.19	25.29	17	33324	526424	79184623
Pulmonary haemorrhage	155.04	25.29	89	33252	14628	79696419
Arthralgia	153.86	25.29	27	33314	571776	79139271
Bronchopulmonary aspergillosis	146.73	25.29	100	33241	22194	79688853
Bone marrow failure	146.63	25.29	141	33200	50966	79660081
Fall	145.17	25.29	17	33324	487612	79223435
JC virus infection	140.45	25.29	55	33286	3826	79707221
Acute myeloid leukaemia	138.70	25.29	110	33231	30775	79680272
Respiratory failure	138.42	25.29	261	33080	180650	79530397
End stage renal disease	137.07	25.29	77	33264	12143	79698904
Epstein-Barr virus infection reactivation	133.64	25.29	44	33297	1848	79709199
Cytomegalovirus test positive	133.55	25.29	60	33281	5887	79705160
Bone marrow transplant rejection	131.09	25.29	29	33312	250	79710797
Acute lymphocytic leukaemia recurrent	129.99	25.29	55	33286	4669	79706378
Toxoplasmosis	129.47	25.29	47	33294	2650	79708397
Progressive multifocal leukoencephalopathy	125.23	25.29	88	33253	20512	79690535
Pain	118.84	25.29	74	33267	703728	79007319
Thrombocytopenia	118.09	25.29	308	33033	264951	79446096
Epstein-Barr viraemia	115.54	25.29	41	33300	2164	79708883
Pneumonia cytomegaloviral	114.35	25.29	51	33290	4918	79706129
Haemophagocytic lymphohistiocytosis	113.86	25.29	85	33256	21752	79689295
Primary hypogonadism	113.53	25.29	24	33317	163	79710884
Chronic graft versus host disease in liver	110.64	25.29	30	33311	637	79710410
Haematotoxicity	110.25	25.29	73	33268	15446	79695601
Stomatitis	110.07	25.29	210	33131	146547	79564500
Engraft failure	108.66	25.29	30	33311	683	79710364
Pain in extremity	107.70	25.29	13	33328	364525	79346522
Graft versus host disease in liver	104.92	25.29	36	33305	1718	79709329
Mucormycosis	102.20	25.29	56	33285	8413	79702634
Acute respiratory distress syndrome	101.54	25.29	108	33233	43959	79667088
Drug hypersensitivity	100.97	25.29	6	33335	298910	79412137
Engraftment syndrome	100.45	25.29	33	33308	1376	79709671
Peripheral swelling	99.03	25.29	3	33338	269614	79441433
Dyspnoea	98.33	25.29	129	33212	856896	78854151
Headache	95.61	25.29	80	33261	653692	79057355
Stem cell transplant	94.90	25.29	41	33300	3663	79707384
Neurotoxicity	93.79	25.29	90	33251	32428	79678619
Graft versus host disease in lung	92.69	25.29	28	33313	884	79710163
Chronic graft versus host disease in intestine	92.51	25.29	23	33318	342	79710705
Asthenia	88.78	25.29	52	33289	511637	79199410
Abdominal discomfort	87.92	25.29	4	33337	250723	79460324
Pruritus	87.62	25.29	28	33313	394620	79316427
Epstein-Barr virus associated lymphoproliferative disorder	86.91	25.29	38	33303	3494	79707553
Product dose omission issue	86.63	25.29	4	33337	247533	79463514
Nasopharyngitis	86.02	25.29	5	33336	253876	79457171
Obliterative bronchiolitis	85.80	25.29	36	33305	2992	79708055
Bacterial sepsis	84.80	25.29	49	33292	8149	79702898
Sepsis	83.48	25.29	275	33066	269153	79441894
Aspergillus infection	83.36	25.29	67	33274	19094	79691953
Cytomegalovirus chorioretinitis	82.40	25.29	42	33299	5448	79705599
Transplant dysfunction	82.34	25.29	46	33295	7175	79703872
Encephalitis cytomegalovirus	82.25	25.29	27	33314	1123	79709924
Infusion related reaction	79.67	25.29	4	33337	230233	79480814
Complications of bone marrow transplant	79.50	25.29	23	33318	623	79710424
Ascites	77.27	25.29	124	33217	75438	79635609
Transplant rejection	76.25	25.29	64	33277	19373	79691674
Autoimmune haemolytic anaemia	75.97	25.29	46	33295	8334	79702713
Anxiety	75.53	25.29	8	33333	248504	79462543
Adenoviral hepatitis	75.42	25.29	24	33317	903	79710144
Human polyomavirus infection	75.23	25.29	25	33316	1081	79709966
Gastrointestinal toxicity	74.77	25.29	45	33296	8064	79702983
Back pain	74.16	25.29	18	33323	304162	79406885
Human herpesvirus 6 encephalitis	74.03	25.29	22	33319	656	79710391
Cerebral toxoplasmosis	73.41	25.29	30	33311	2332	79708715
Upper respiratory fungal infection	73.34	25.29	19	33322	336	79710711
Systemic mycosis	73.22	25.29	31	33310	2635	79708412
Pulmonary veno-occlusive disease	72.74	25.29	27	33314	1621	79709426
Stenotrophomonas infection	71.99	25.29	34	33307	3739	79707308
Drug resistance	69.51	25.29	87	33254	42126	79668921
Malaise	69.03	25.29	62	33279	489807	79221240
Septic shock	68.88	25.29	156	33185	122645	79588402
Swelling	68.43	25.29	6	33335	216705	79494342
Pulmonary alveolar haemorrhage	67.44	25.29	48	33293	11409	79699638
Pyrexia	67.13	25.29	499	32842	678210	79032837
Nausea	67.10	25.29	193	33148	957003	78754044
Hepatic failure	66.10	25.29	103	33238	61109	79649938
Weight decreased	66.07	25.29	33	33308	355165	79355882
Hypersensitivity	64.94	25.29	15	33326	262224	79448823
Cardiotoxicity	64.60	25.29	48	33293	12191	79698856
Rash	63.21	25.29	90	33251	578268	79132779
Constipation	62.93	25.29	20	33321	283030	79428017
Staphylococcal infection	62.82	25.29	98	33243	58197	79652850
Neoplasm recurrence	62.56	25.29	32	33309	4182	79706865
Cytomegalovirus urinary tract infection	62.32	25.29	13	33328	82	79710965
Urticaria	61.66	25.29	4	33337	185197	79525850
Blood stem cell transplant failure	61.21	25.29	18	33323	517	79710530
Disseminated toxoplasmosis	60.59	25.29	15	33326	219	79710828
Pericardial effusion	60.27	25.29	85	33256	46152	79664895
Syncope	59.38	25.29	4	33337	179445	79531602
Chest pain	59.21	25.29	22	33319	282282	79428765
Myelodysplastic syndrome	58.98	25.29	68	33273	30233	79680814
Blood pressure increased	58.91	25.29	9	33332	211351	79499696
Encephalitis	58.72	25.29	49	33292	14711	79696336
Autoimmune lymphoproliferative syndrome	58.56	25.29	14	33327	175	79710872
Polyomavirus viraemia	57.60	25.29	23	33318	1684	79709363
Gait disturbance	57.46	25.29	9	33332	207497	79503550
Somnolence	56.58	25.29	15	33326	238966	79472081
Skin toxicity	56.38	25.29	38	33303	8276	79702771
Myalgia	56.33	25.29	6	33335	185635	79525412
Respiratory distress	55.93	25.29	93	33248	58246	79652801
Hepatic vein occlusion	55.89	25.29	14	33327	215	79710832
Hepatomegaly	55.86	25.29	53	33288	18821	79692226
Condition aggravated	54.71	25.29	78	33263	501046	79210001
Depression	54.47	25.29	12	33329	216778	79494269
Feeling abnormal	54.32	25.29	3	33338	159196	79551851
Seizure	54.24	25.29	188	33153	188646	79522401
Bone marrow transplant	54.09	25.29	21	33320	1427	79709620
Infection reactivation	53.96	25.29	25	33316	2632	79708415
Pseudomonal sepsis	53.69	25.29	33	33308	6141	79704906
Recurrent cancer	53.64	25.29	25	33316	2668	79708379
Enterococcal bacteraemia	53.53	25.29	26	33315	3042	79708005
Insomnia	53.30	25.29	18	33323	245152	79465895
Myelitis	53.29	25.29	24	33317	2367	79708680
Mucosal disorder	52.98	25.29	27	33314	3501	79707546
Staphylococcal sepsis	52.69	25.29	46	33295	14680	79696367
Candida sepsis	52.15	25.29	24	33317	2489	79708558
Pathogen resistance	51.72	25.29	45	33296	14297	79696750
Laryngitis fungal	51.44	25.29	12	33329	134	79710913
Graft versus host disease in eye	51.29	25.29	14	33327	305	79710742
Chloroma	50.76	25.29	17	33324	753	79710294
Neutropenia	49.09	25.29	244	33097	287466	79423581
Alternaria infection	48.73	25.29	16	33325	666	79710381
Hyperhidrosis	48.34	25.29	4	33337	151488	79559559
Growth retardation	48.12	25.29	21	33320	1922	79709125
Synovitis	48.05	25.29	4	33337	150730	79560317
Abdominal pain upper	47.67	25.29	17	33324	223802	79487245
Hypotension	47.58	25.29	69	33272	440248	79270799
Meningitis tuberculous	46.88	25.29	18	33323	1187	79709860
Tooth hypoplasia	46.71	25.29	12	33329	205	79710842
Overdose	46.67	25.29	10	33331	184196	79526851
Myocardial infarction	46.64	25.29	10	33331	184119	79526928
Pneumocystis jirovecii pneumonia	45.72	25.29	62	33279	32446	79678601
Cytopenia	45.26	25.29	49	33292	20334	79690713
Candida infection	45.06	25.29	67	33274	38147	79672900
Dehydration	44.72	25.29	24	33317	248163	79462884
Pneumonia fungal	44.15	25.29	37	33304	11173	79699874
Myelosuppression	43.77	25.29	68	33273	40228	79670819
Urinary tract infection	43.30	25.29	31	33310	274481	79436566
Blood bilirubin increased	42.66	25.29	89	33252	66143	79644904
Varicella zoster virus infection	41.87	25.29	25	33316	4416	79706631
Staphylococcal bacteraemia	41.39	25.29	37	33304	12181	79698866
Sinusitis	41.37	25.29	15	33326	195486	79515561
Meningoencephalitis herpetic	41.29	25.29	19	33322	1970	79709077
Diffuse alveolar damage	41.20	25.29	23	33318	3581	79707466
Alopecia	40.77	25.29	23	33318	231332	79479715
Cerebrovascular accident	40.23	25.29	8	33333	155284	79555763
Gastroenteritis adenovirus	40.02	25.29	12	33329	369	79710678
Hepatic necrosis	39.96	25.29	32	33309	9068	79701979
Disseminated mucormycosis	39.54	25.29	14	33327	734	79710313
Asthma	39.40	25.29	5	33336	135090	79575957
Poikiloderma	39.36	25.29	12	33329	391	79710656
Confusional state	39.32	25.29	45	33296	317952	79393095
Fungal infection	39.27	25.29	66	33275	41682	79669365
Systemic candida	39.25	25.29	28	33313	6678	79704369
Product administration error	39.23	25.29	57	33284	31789	79679258
Clostridium difficile colitis	38.64	25.29	57	33284	32226	79678821
Aplasia pure red cell	37.61	25.29	29	33312	7781	79703266
Aplasia	37.58	25.29	29	33312	7791	79703256
Renal failure	37.54	25.29	175	33166	200793	79510254
Enterococcal infection	37.16	25.29	39	33302	15621	79695426
Immune thrombocytopenia	36.41	25.29	41	33300	17764	79693283
Respiratory tract infection fungal	36.32	25.29	15	33326	1198	79709849
Sweat gland tumour	36.17	25.29	12	33329	516	79710531
Fungaemia	36.05	25.29	23	33318	4568	79706479
Eccrine squamous syringometaplasia	35.63	25.29	7	33334	31	79711016
Memory impairment	35.51	25.29	3	33338	111731	79599316
Lactobacillus infection	35.38	25.29	11	33330	383	79710664
Disseminated intravascular coagulation	34.16	25.29	57	33284	35785	79675262
Citrobacter bacteraemia	33.46	25.29	6	33335	14	79711033
Cardiac tamponade	33.23	25.29	29	33312	9247	79701800
Pneumonia respiratory syncytial viral	32.92	25.29	16	33325	1874	79709173
Hypoaesthesia	32.81	25.29	17	33324	179335	79531712
Reticulocytosis	32.61	25.29	11	33330	498	79710549
Gastrooesophageal reflux disease	32.58	25.29	3	33338	104243	79606804
Abdominal pain	32.23	25.29	72	33269	389497	79321550
Focal nodular hyperplasia	32.18	25.29	12	33329	730	79710317
Neutropenic infection	31.94	25.29	17	33324	2410	79708637
Palpitations	31.81	25.29	7	33334	126603	79584444
Haptoglobin decreased	31.55	25.29	14	33327	1333	79709714
Hypoglycaemia	31.55	25.29	3	33338	101591	79609456
Bacterial infection	31.51	25.29	51	33290	31229	79679818
Muscle spasms	31.32	25.29	17	33324	174713	79536334
Bradycardia	31.15	25.29	9	33332	135548	79575499
Refractoriness to platelet transfusion	30.85	25.29	8	33333	142	79710905
Tooth development disorder	30.80	25.29	7	33334	69	79710978
Device related infection	30.65	25.29	53	33288	34241	79676806
Retinopathy haemorrhagic	30.62	25.29	7	33334	71	79710976
Coombs direct test positive	30.34	25.29	10	33331	421	79710626
Pulmonary hypertension	30.25	25.29	64	33277	48016	79663031
Microangiopathy	30.14	25.29	15	33326	1850	79709197
Drug intolerance	29.88	25.29	40	33301	264079	79446968
General physical health deterioration	29.83	25.29	43	33298	275195	79435852
Pseudomonas infection	29.60	25.29	40	33301	20863	79690184
Lymphoproliferative disorder	29.58	25.29	22	33319	5593	79705454
Nodular melanoma	29.50	25.29	8	33333	170	79710877
Hyponatraemia	29.48	25.29	19	33322	177829	79533218
Organising pneumonia	29.15	25.29	29	33312	10910	79700137
Paraesthesia	29.00	25.29	19	33322	176304	79534743
Anti-platelet antibody positive	28.85	25.29	9	33332	317	79710730
Acanthamoeba infection	28.79	25.29	10	33331	495	79710552
Transplantation complication	28.53	25.29	9	33332	329	79710718
Adenoviral haemorrhagic cystitis	28.41	25.29	10	33331	515	79710532
Blood bilirubin unconjugated increased	28.28	25.29	12	33329	1025	79710022
Encephalitis viral	28.24	25.29	16	33325	2563	79708484
Hyperfibrinogenaemia	28.10	25.29	7	33334	105	79710942
Disease recurrence	28.08	25.29	59	33282	44050	79666997
Primary adrenal insufficiency	27.93	25.29	8	33333	209	79710838
Metapneumovirus infection	27.80	25.29	14	33327	1770	79709277
Heart rate increased	27.77	25.29	8	33333	120716	79590331
Oedema peripheral	27.74	25.29	39	33302	252249	79458798
Iron overload	27.22	25.29	14	33327	1850	79709197
Haemolysis	27.05	25.29	30	33311	12782	79698265
Portal hypertension	27.04	25.29	23	33318	7085	79703962
Cough	27.02	25.29	72	33269	366717	79344330
Leukoencephalopathy	26.83	25.29	24	33317	7905	79703142
Adenomatous polyposis coli	26.81	25.29	8	33333	242	79710805
Adrenal haemorrhage	26.79	25.29	10	33331	610	79710437
Colitis herpes	26.73	25.29	5	33336	16	79711031
Dysbiosis	26.42	25.29	12	33329	1207	79709840
Flushing	26.39	25.29	3	33338	88265	79622782
Hyperbilirubinaemia	26.10	25.29	41	33300	24477	79686570
Second primary malignancy	25.92	25.29	31	33310	14319	79696728
BK polyomavirus test positive	25.89	25.29	7	33334	147	79710900
Infusion site eschar	25.86	25.29	5	33336	20	79711027
Tooth malformation	25.71	25.29	7	33334	151	79710896
Delayed engraftment	25.58	25.29	8	33333	284	79710763
Oxygen saturation decreased	25.49	25.29	11	33330	129036	79582011
Chest discomfort	25.37	25.29	13	33328	138031	79573016
Pleural effusion	25.30	25.29	124	33217	145138	79565909

FDA Adverse Event Reporting System (Pediatric)

None

Pharmacologic Action:

Source	Code	Description
ATC	L01AB01	ANTINEOPLASTIC AND IMMUNOMODULATING AGENTS ANTINEOPLASTIC AGENTS ALKYLATING AGENTS Alkyl sulfonates
FDA MoA	N0000000236	Alkylating Activity
FDA EPC	N0000175558	Alkylating Drug
MeSH PA	D000477	Alkylating Agents
MeSH PA	D000970	Antineoplastic Agents
MeSH PA	D018906	Antineoplastic Agents, Alkylating
MeSH PA	D007155	Immunologic Factors
MeSH PA	D007166	Immunosuppressive Agents
MeSH PA	D019653	Myeloablative Agonists
MeSH PA	D009676	Noxae
CHEBI has role	CHEBI:35610	antineoplastic agents
CHEBI has role	CHEBI:50903	carcinogen
CHEBI has role	CHEBI:50905	teratogeno
CHEBI has role	CHEBI:67105	insect sterilants

Drug Use | Suggest Off label Use Form| |View source of the data|

Disease	Relation	SNOMED_ID	DOID
Allogeneic bone marrow transplantation	indication	58390007
Malignant lymphoma	indication	118600007	DOID:0060058
Neuroblastoma	indication	432328008	DOID:769
Autologous hematopoietic stem-cell transplantation for Ewing's sarcoma family of tumors	indication	709115004
Philadelphia Chromosome Positive Chronic Myelocytic Leukemia	indication
Mycosis	contraindication	3218000	DOID:1564
Fanconi's anemia	contraindication	30575002	DOID:13636
Viral disease	contraindication	34014006	DOID:934
Hyperuricemia	contraindication	35885006	DOID:1920
Hypokalemia	contraindication	43339004
Fibrosis of lung	contraindication	51615001	DOID:3770
Portal vein obstruction	contraindication	57348003
Hyperglycemia	contraindication	80394007	DOID:4195
Epilepsy	contraindication	84757009	DOID:1826
Bacterial infectious disease	contraindication	87628006
Radiation oncology AND/OR radiotherapy	contraindication	108290001
Hypomagnesemia	contraindication	190855004
Anemia	contraindication	271737000	DOID:2355
Pregnancy, function	contraindication	289908002
Thrombocytopenic disorder	contraindication	302215000	DOID:1588
Neutropenic disorder	contraindication	303011007	DOID:1227
Breastfeeding (mother)	contraindication	413712001
Severe Bone Marrow Depression	contraindication

🐶 Veterinary Drug Use

None

🐶 Veterinary products

None

Acid dissociation constants calculated using MoKa v3.0.0

None

Orange Book patent data (new drug applications)

None

Orange Book exclusivity data (new drug applications)

None

Bioactivity Summary:

Target	Class	Pharos	UniProt	Action	Type	Activity value (-log[M])	Mechanism action	Bioact source	MoA source
Matrix metalloproteinase-9	Enzyme	P14780	MMP9_HUMAN		IC50	5.28		DRUG MATRIX

External reference:

ID	Source
4018773	VUID
N0000147076	NUI
D00248	KEGG_DRUG
1828	RXNORM
C0006463	UMLSCUI
CHEBI:28901	CHEBI
CHEMBL820	ChEMBL_ID
DB01008	DRUGBANK_ID
D002066	MESH_DESCRIPTOR_UI
2478	PUBCHEM_CID
7136	IUPHAR_LIGAND_ID
564	INN_ID
G1LN9045DK	UNII
121305	MMSL
37850	MMSL
4309	MMSL
d00183	MMSL
2571007	SNOMEDCT_US
387138002	SNOMEDCT_US
4018773	VANDF
002638	NDDF

Pharmaceutical products:

Product	Category	Ingredients	NDC	Form	Quantity	Route	Marketing	Label
BUSULFAN	HUMAN PRESCRIPTION DRUG LABEL	1	0409-1112	INJECTION, SOLUTION	6 mg	INTRAVENOUS	ANDA	28 sections
BUSULFAN	HUMAN PRESCRIPTION DRUG LABEL	1	0517-0920	INJECTION	6 mg	INTRAVENOUS	ANDA	27 sections
Busulfan	HUMAN PRESCRIPTION DRUG LABEL	1	16729-351	INJECTION	6 mg	INTRAVENOUS	ANDA	27 sections
Busulfan	HUMAN PRESCRIPTION DRUG LABEL	1	25021-241	INJECTION, SOLUTION, CONCENTRATE	6 mg	INTRAVENOUS	ANDA	27 sections
Busulfan	HUMAN PRESCRIPTION DRUG LABEL	1	25021-241	INJECTION, SOLUTION, CONCENTRATE	6 mg	INTRAVENOUS	ANDA	27 sections
Busulfan	HUMAN PRESCRIPTION DRUG LABEL	1	51817-170	INJECTION	6 mg	INTRAVENOUS	ANDA	28 sections
Busulfan	HUMAN PRESCRIPTION DRUG LABEL	1	51817-170	INJECTION	6 mg	INTRAVENOUS	ANDA	28 sections
BUSULFEX	HUMAN PRESCRIPTION DRUG LABEL	1	59148-070	INJECTION	6 mg	INTRAVENOUS	NDA	28 sections
BUSULFEX	HUMAN PRESCRIPTION DRUG LABEL	1	59148-070	INJECTION	6 mg	INTRAVENOUS	NDA	28 sections
Busulfan	HUMAN PRESCRIPTION DRUG LABEL	1	60505-6177	INJECTION	6 mg	INTRAVENOUS	ANDA	27 sections
Busulfan	HUMAN PRESCRIPTION DRUG LABEL	1	65219-160	INJECTION	6 mg	INTRAVENOUS	ANDA	27 sections
Busulfan	HUMAN PRESCRIPTION DRUG LABEL	1	67457-893	INJECTION	6 mg	INTRAVENOUS	ANDA	28 sections
MYLERAN	HUMAN PRESCRIPTION DRUG LABEL	1	69784-620	TABLET, FILM COATED	2 mg	ORAL	NDA	23 sections
MYLERAN	HUMAN PRESCRIPTION DRUG LABEL	1	69784-620	TABLET, FILM COATED	2 mg	ORAL	NDA	23 sections
Busulfan	HUMAN PRESCRIPTION DRUG LABEL	1	70121-1244	INJECTION	6 mg	INTRAVENOUS	ANDA	27 sections
Busulfan	HUMAN PRESCRIPTION DRUG LABEL	1	70121-1244	INJECTION	6 mg	INTRAVENOUS	ANDA	27 sections
Busulfan	HUMAN PRESCRIPTION DRUG LABEL	1	71288-116	INJECTION, SOLUTION	6 mg	INTRAVENOUS	ANDA	27 sections
Busulfan	HUMAN PRESCRIPTION DRUG LABEL	1	71288-158	INJECTION, SOLUTION	6 mg	INTRAVENOUS	ANDA	28 sections
Busulfan	HUMAN PRESCRIPTION DRUG LABEL	1	72485-210	INJECTION, SOLUTION	6 mg	INTRAVENOUS	ANDA	28 sections
Busulfan	HUMAN PRESCRIPTION DRUG LABEL	1	72606-559	INJECTION	6 mg	INTRAVENOUS	ANDA	28 sections
MYLERAN	HUMAN PRESCRIPTION DRUG LABEL	1	76388-713	TABLET, FILM COATED	2 mg	ORAL	NDA	23 sections
MYLERAN	HUMAN PRESCRIPTION DRUG LABEL	1	76388-713	TABLET, FILM COATED	2 mg	ORAL	NDA	23 sections
MYLERAN	HUMAN PRESCRIPTION DRUG LABEL	1	80725-620	TABLET, FILM COATED	2 mg	ORAL	NDA	23 sections