sodium benzoate 🐶 Veterinary Use | Indications/Contra | FAERs-F | FAERs-M | Orange Bk | PK/Tox | Related Drugs | BioActivity |

Stem definitionDrug idCAS RN
4373 532-32-1

Description:

MoleculeDescription

Synonyms:

  • sodium benzoate
The sodium salt of BENZOIC ACID. It is used as an antifungal preservative in pharmaceutical preparations and foods. It may also be used as a test for liver function.
  • Molecular weight: 144.11
  • Formula: C7H5NaO2
  • CLOGP:
  • LIPINSKI: None
  • HAC: None
  • HDO: None
  • TPSA: 40.13
  • ALOGS:
  • ROTB: None

Drug dosage:

None

ADMET properties:

None

Predicted pharmacokinetic/toxicological properties (PK-AZ):

None

Approvals:

DateAgencyCompanyOrphan
Dec. 23, 1987 FDA

FDA Adverse Event Reporting System (Female)

MedDRA adverse event termLikelihood ratioLikelihood ratio thresholdPatients taking drug having adverse eventPatients taking drug not having adverse eventPatients not taking drug having adverse eventPatients not taking drug not having adverse event
Creatinine renal clearance decreased 174.20 124.24 39 774 18860 90608774
Sedation complication 167.31 124.24 37 776 16907 90610727
Orthostatic hypotension 157.61 124.24 42 771 41785 90585849
Blood calcium decreased 156.04 124.24 39 774 30143 90597491
Sedation 128.92 124.24 37 776 48134 90579500
Cognitive disorder 128.10 124.24 40 773 69367 90558267

FDA Adverse Event Reporting System (Male)

None

FDA Adverse Event Reporting System (Geriatric)

MedDRA adverse event termLikelihood ratioLikelihood ratio thresholdPatients taking drug having adverse eventPatients taking drug not having adverse eventPatients not taking drug having adverse eventPatients not taking drug not having adverse event
Creatinine renal clearance decreased 184.97 98.09 42 941 21773 110566543
Sedation complication 177.93 98.09 40 943 19815 110568501
Blood calcium decreased 164.24 98.09 42 941 35803 110552513
Orthostatic hypotension 151.74 98.09 45 938 66204 110522112
Cognitive disorder 135.30 98.09 44 939 87467 110500849
Sedation 123.94 98.09 39 944 69644 110518672
Depressed level of consciousness 116.93 98.09 42 941 112236 110476080
Balance disorder 115.40 98.09 42 941 116518 110471798
Hyperammonaemia 108.49 98.09 25 958 13707 110574609

FDA Adverse Event Reporting System (Pediatric)

None

Pharmacologic Action:

SourceCodeDescription
ATC A16AX11 ALIMENTARY TRACT AND METABOLISM
OTHER ALIMENTARY TRACT AND METABOLISM PRODUCTS
OTHER ALIMENTARY TRACT AND METABOLISM PRODUCTS
Various alimentary tract and metabolism products
ATC A16AX30 ALIMENTARY TRACT AND METABOLISM
OTHER ALIMENTARY TRACT AND METABOLISM PRODUCTS
OTHER ALIMENTARY TRACT AND METABOLISM PRODUCTS
Various alimentary tract and metabolism products
ATC V04CG30 VARIOUS
DIAGNOSTIC AGENTS
OTHER DIAGNOSTIC AGENTS
Tests for gastric secretion
MeSH PA D000890 Anti-Infective Agents
MeSH PA D000935 Antifungal Agents
MeSH PA D005503 Food Additives
MeSH PA D005520 Food Preservatives
CHEBI has role CHEBI:35476 antipsychotic agent
CHEBI has role CHEBI:64996 EC 1.13.11.33 (arachidonate 15-lipoxygenase) inhibitor
CHEBI has role CHEBI:65001 EC 3.1.1.3 (triacylglycerol lipase) inhibitor
CHEBI has role CHEBI:65256 antimicrobial food preservative
CHEBI has role CHEBI:76924 plant metabolite
CHEBI has role CHEBI:76967 human xenobiotic metabolite
CHEBI has role CHEBI:84735 algal metabolite
CHEBI has role CHEBI:88188 drug allergen

Related Drugs by ATC class:

A16AX Various alimentary tract and metabolism products 23 drugs
anethole trithionedoxecitinedoxribtimineeliglustatfosdenopteringivosiranglycerol phenylbutyratelonafarniblumasiranmigalastatmiglustatnedosiran show all 23 →
V04CG Tests for gastric secretion 5 drugs
betazolecaffeinehistaminemethylthioninium chloridepentagastrin

Drug Use | Suggest Off label Use Form| |View source of the data|

DiseaseRelationSNOMED_IDDOID
Hyperammonemia indication 9360008
Apnea in the newborn indication 13094009
Fatigue off-label use 84229001
Drowsy off-label use 271782001
Necrotizing enterocolitis in fetus OR newborn contraindication 2707005
Peptic ulcer contraindication 13200003 DOID:750
Hypertensive disorder contraindication 38341003 DOID:10763
Hypokalemia contraindication 43339004
Body fluid retention contraindication 43498006
Conduction disorder of the heart contraindication 44808001
Chronic heart failure contraindication 48447003
Acute nephropathy contraindication 58574008
Metabolic acidosis contraindication 59455009
Hepatic failure contraindication 59927004
Agoraphobia contraindication 70691001 DOID:593
Hyperglycemia contraindication 80394007 DOID:4195
Kidney disease contraindication 90708001 DOID:557
Seizure disorder contraindication 128613002
Obsessive-compulsive disorder contraindication 191736004 DOID:10933
Insomnia contraindication 193462001
Impaired renal function disorder contraindication 197663003
Disease of liver contraindication 235856003 DOID:409
Edema contraindication 267038008
Panic disorder contraindication 371631005 DOID:594
Myocardial ischemia contraindication 414795007 DOID:3393
Myocardial infarction in recovery phase contraindication 418044006
CNS Toxicity contraindication




🐶 Veterinary Drug Use

None

🐶 Veterinary products

None

Acid dissociation constants calculated using MoKa v3.0.0

None

Orange Book patent data (new drug applications)

None

Orange Book exclusivity data (new drug applications)

None

Bioactivity Summary:

TargetClassPharosUniProtActionTypeActivity value
(-log[M])		Mechanism
action		Bioact sourceMoA source
Carbonic anhydrase 2 Enzyme Ki 4.52 CHEMBL
Carbonic anhydrase 4 Enzyme Ki 4.13 CHEMBL
Carbonic anhydrase Enzyme Ki 4.61 CHEMBL

External reference:

IDSource
D02277 KEGG_DRUG
4017797 VUID
N0000146158 NUI
4017797 VANDF
C0142805 UMLSCUI
CHEBI:113455 CHEBI
CHEMBL1356 ChEMBL_ID
OJ245FE5EU UNII
517055 PUBCHEM_CID
56455 RXNORM
5206 MMSL
5472 MMSL
d03096 MMSL
001243 NDDF
003194 NDDF
125706008 SNOMEDCT_US
398718007 SNOMEDCT_US
D020160 MESH_DESCRIPTOR_UI

Pharmaceutical products:

ProductCategoryIngredientsNDCFormQuantityRouteMarketingLabel
Ammonul HUMAN PRESCRIPTION DRUG LABEL 2 62592-720 INJECTION, SOLUTION, CONCENTRATE 100 mg INTRAVENOUS NDA 28 sections
SODIUM PHENYLACETATE AND SODIUM BENZOATE HUMAN PRESCRIPTION DRUG LABEL 2 68382-396 INJECTION, SOLUTION, CONCENTRATE 100 mg INTRAVENOUS ANDA 24 sections
Sodium Phenylacetate and sodium benzoate HUMAN PRESCRIPTION DRUG LABEL 2 68475-001 INJECTION, SOLUTION, CONCENTRATE 100 mg INTRAVENOUS ANDA 24 sections
Sodium phenylacetate and Sodium benzoate HUMAN PRESCRIPTION DRUG LABEL 2 68475-513 INJECTION, SOLUTION, CONCENTRATE 100 mg INTRAVENOUS ANDA 24 sections
SODIUM PHENYLACETATE AND SODIUM BENZOATE HUMAN PRESCRIPTION DRUG LABEL 2 70511-101 INJECTION, SOLUTION, CONCENTRATE 100 mg INTRAVENOUS ANDA 28 sections
Sodium Phenylacetate and Sodium Benzoate HUMAN PRESCRIPTION DRUG LABEL 2 70511-102 INJECTION 100 mg INTRAVENOUS NDA 29 sections
SODIUM PHENYLACETATE and SODIUM BENZOATE HUMAN PRESCRIPTION DRUG LABEL 2 70556-100 INJECTION, SOLUTION, CONCENTRATE 100 mg INTRAVENOUS ANDA 28 sections
Sodium phenylacetate and Sodium benzoate HUMAN PRESCRIPTION DRUG LABEL 2 70710-1926 INJECTION, SOLUTION, CONCENTRATE 100 mg INTRAVENOUS ANDA 24 sections
Sodium Phenylacetate and Sodium Benzoate HUMAN PRESCRIPTION DRUG LABEL 2 72266-236 INJECTION 100 mg INTRAVENOUS NDA 29 sections
seo jeong ho hwang chill mist HUMAN OTC DRUG LABEL 1 76675-0006 LIQUID 0.50 g TOPICAL unapproved drug other 7 sections
seo jeong ho hwang chill deodorant HUMAN OTC DRUG LABEL 1 76675-0008 LIQUID 0.50 g TOPICAL unapproved drug other 7 sections
s panax mist for refill HUMAN OTC DRUG LABEL 1 76675-0011 LIQUID 0.50 g TOPICAL unapproved drug other 7 sections
s panax mist HUMAN OTC DRUG LABEL 1 76675-0013 LIQUID 0.50 g TOPICAL unapproved drug other 7 sections
SODIUM PHENYLACETATE and SODIUM BENZOATE HUMAN PRESCRIPTION DRUG LABEL 2 81665-203 INJECTION, SOLUTION, CONCENTRATE 100 mg INTRAVENOUS ANDA 28 sections
SODIUM PHENYLACETATE and SODIUM BENZOATE HUMAN PRESCRIPTION DRUG LABEL 2 81665-204 INJECTION, SOLUTION, CONCENTRATE 100 mg INTRAVENOUS ANDA 28 sections
s panax all in one mist HUMAN OTC DRUG LABEL 1 81885-0002 LIQUID 0.50 g TOPICAL unapproved drug other 7 sections
GKV Anti Dandruff Smooth HUMAN OTC DRUG LABEL 7 84558-001 SHAMPOO 0.40 g TOPICAL OTC Monograph Drug 12 sections