betazole Indications/Contra | FAERs-F | FAERs-M | Orange Bk | BioActivity |

Stem definitionDrug idCAS RN
357 105-20-4

Description:

MoleculeDescription

Molfile Inchi Smiles

Synonyms:

  • betazole hydrochloride
  • betazole
  • betazole HCl
  • histalog
  • betazole dihydrochloride
  • ametazole
A histamine H2 agonist used clinically to test gastric secretory function.
  • Molecular weight: 111.15
  • Formula: C5H9N3
  • CLOGP: -0.70
  • LIPINSKI: 0
  • HAC: 3
  • HDO: 2
  • TPSA: 54.70
  • ALOGS: 0.19
  • ROTB: 2

  • Status: OFM

  • Legend:
    OFP - off patent
    OFM - off market
    ONP - on patent

Drug dosage:

None

ADMET properties:

PropertyValueReference
MRTD (Maximum Recommended Therapeutic Daily Dose) 4.50 ┬ÁM/kg/day Contrera JF, Matthews EJ, Kruhlak NL, Benz RD

Approvals:

DateAgencyCompanyOrphan
None FDA LILLY

FDA Adverse Event Reporting System (Female)

None

FDA Adverse Event Reporting System (Male)

None

Pharmacologic Action:

SourceCodeDescription
ATC V04CG02 VARIOUS
DIAGNOSTIC AGENTS
OTHER DIAGNOSTIC AGENTS
Tests for gastric secretion
MeSH PA D005765 Gastrointestinal Agents
MeSH PA D018494 Histamine Agents
MeSH PA D017442 Histamine Agonists
MeSH PA D018377 Neurotransmitter Agents
CHEBI has role CHEBI:33295 diagnostic aid
CHEBI has role CHEBI:35678 histamine agonists
CHEBI has role CHEBI:55324 gastrointestinal agents

Drug Use (View source of the data)

DiseaseRelationSNOMED_IDDOID
Stimulated gastric secretory test indication 252660000

Acid dissociation constants calculated using MoKa v3.0.0

Dissociation levelDissociation constantType (acidic/basic)
pKa1 9.7 Basic
pKa2 1.84 Basic

Orange Book patent data (new drug applications)

None

Orange Book exclusivity data (new drug applications)

None

Bioactivity Summary:

TargetClassPharosUniProtActionTypeActivity value
(-log[M])
Mechanism
action
Bioact sourceMoA source
Histamine H2 receptor GPCR AGONIST WOMBAT-PK CHEMBL

External reference:

IDSource
1C065P542O UNII
D01187 KEGG_DRUG
138-92-1 SECONDARY_CAS_RN
4027250 VANDF
C0005321 UMLSCUI
CHEBI:59170 CHEBI
CHEMBL1200949 ChEMBL_ID
CHEMBL1201323 ChEMBL_ID
DB00272 DRUGBANK_ID
D001625 MESH_DESCRIPTOR_UI
7741 PUBCHEM_CID
574 INN_ID
7126 IUPHAR_LIGAND_ID
003367 NDDF
004786 NDDF
2125008 SNOMEDCT_US
260241009 SNOMEDCT_US

Pharmaceutical products:

None