buspirone 🐶 Veterinary Use | Indications/Contra | FAERs-F | FAERs-M | Orange Bk | BioActivity |

Stem definition	Drug id	CAS RN
anxiolytics, buspirone derivatives	437	36505-84-7

Description:

Molecule	Description
Molfile Inchi Smiles Synonyms: buspirone buspin buspirone hydrochloride buspirone HCl	An anxiolytic agent and serotonin receptor agonist belonging to the azaspirodecanedione class of compounds. Its structure is unrelated to those of the BENZODIAZAPINES, but it has an efficacy comparable to DIAZEPAM. Molecular weight: 385.51 Formula: C21H31N5O2 CLOGP: 2.24 LIPINSKI: 0 HAC: 7 HDO: 0 TPSA: 69.64 ALOGS: -2.82 ROTB: 6 Status: OFP Legend: OFP - off patent OFM - off market ONP - on patent

Molecule

Description

Molfile Inchi Smiles

Synonyms:

buspirone
buspin
buspirone hydrochloride
buspirone HCl

An anxiolytic agent and serotonin receptor agonist belonging to the azaspirodecanedione class of compounds. Its structure is unrelated to those of the BENZODIAZAPINES, but it has an efficacy comparable to DIAZEPAM.

Molecular weight: 385.51
Formula: C21H31N5O2
CLOGP: 2.24
LIPINSKI: 0
HAC: 7
HDO: 0
TPSA: 69.64
ALOGS: -2.82
ROTB: 6

Status: OFP

Legend:
OFP - off patent
OFM - off market
ONP - on patent

Drug dosage:

Dose	Unit	Route
30	mg	O

ADMET properties:

Property	Value	Reference
BDDCS (Biopharmaceutical Drug Disposition Classification System)	2	Benet LZ, Broccatelli F, Oprea TI
S (Water solubility)	0.02 mg/mL	Benet LZ, Broccatelli F, Oprea TI
EoM (Fraction excreted unchanged in urine)	0.10 %	Benet LZ, Broccatelli F, Oprea TI
MRTD (Maximum Recommended Therapeutic Daily Dose)	2.59 µM/kg/day	Contrera JF, Matthews EJ, Kruhlak NL, Benz RD
BA (Bioavailability)	3.90 %	Kim MT, Sedykh A, Chakravarti SK, Saiakhov RD, Zhu H

Approvals:

Date	Agency	Company	Orphan
Sept. 29, 1986	FDA

FDA Adverse Event Reporting System (Female)

MedDRA adverse event term	Likelihood ratio	Likelihood ratio threshold	Patients taking drug having adverse event	Patients taking drug not having adverse event	Patients not taking drug having adverse event	Patients not taking drug not having adverse event
Completed suicide	525.87	13.08	476	28818	145197	63314531
Serotonin syndrome	225.30	13.08	149	29145	28533	63431195
Depression	157.69	13.08	306	28988	196186	63263542
Suicidal ideation	146.91	13.08	162	29132	62259	63397469
Anxiety	133.96	13.08	304	28990	217237	63242491
Toxicity to various agents	98.01	13.08	293	29001	246957	63212771
Contraindicated product administered	83.69	13.08	4	29290	217644	63242084
Product dose omission issue	78.43	13.08	262	29032	234051	63225677
Withdrawal syndrome	69.23	13.08	64	29230	19933	63439795
Drug intolerance	67.49	13.08	29	29265	308632	63151096
Synovitis	59.33	13.08	8	29286	186910	63272818
Hand deformity	55.21	13.08	5	29289	159452	63300276
Treatment failure	53.53	13.08	13	29281	199030	63260698
Panic attack	52.56	13.08	58	29236	22273	63437455
Dermatitis atopic	52.02	13.08	40	29254	9684	63450044
Cardio-respiratory arrest	47.49	13.08	93	29201	59866	63399862
Insomnia	46.77	13.08	210	29084	215042	63244686
Systemic lupus erythematosus	45.04	13.08	20	29274	208898	63250830
Migraine	44.22	13.08	126	29168	103220	63356508
General physical health deterioration	43.86	13.08	19	29275	201383	63258345
Disturbance in attention	42.85	13.08	69	29225	38120	63421608
Tremor	42.52	13.08	146	29148	132093	63327635
Suspected suicide	41.82	13.08	30	29264	6538	63453190
Wound	41.36	13.08	12	29282	163251	63296477
Somnolence	40.83	13.08	177	29117	178508	63281220
Joint swelling	39.72	13.08	56	29238	327610	63132118
Infusion related reaction	39.69	13.08	33	29261	245488	63214240
Agitation	39.46	13.08	86	29208	59671	63400057
Drug abuse	38.71	13.08	96	29198	72422	63387306
Overdose	38.71	13.08	129	29165	114949	63344779
Arthropathy	37.41	13.08	32	29262	234760	63224968
Stiff person syndrome	36.17	13.08	11	29283	321	63459407
Drug withdrawal syndrome	35.94	13.08	53	29241	27141	63432587
Febrile neutropenia	35.44	13.08	6	29288	118443	63341285
Anoxia	35.31	13.08	10	29284	226	63459502
Hepatic enzyme increased	32.94	13.08	27	29267	202301	63257427
Swelling	32.44	13.08	48	29246	275330	63184398
Intentional overdose	32.29	13.08	91	29203	74061	63385667
Thrombocytopenia	31.74	13.08	15	29279	151142	63308586
Pre-existing condition improved	31.71	13.08	28	29266	8216	63451512
Feeling abnormal	31.62	13.08	144	29150	148248	63311480
Alopecia	31.52	13.08	68	29226	337468	63122260
Hypothermia	31.49	13.08	35	29259	13546	63446182
COVID-19	31.36	13.08	119	29175	112984	63346744
Neutropenia	30.20	13.08	22	29272	174983	63284745
Emotional disorder	30.20	13.08	34	29260	13345	63446383
Lower respiratory tract infection	29.57	13.08	12	29282	132295	63327433
Total cholesterol/HDL ratio abnormal	29.41	13.08	7	29287	77	63459651
Mental disorder	29.31	13.08	47	29247	25872	63433856
Drug screen false positive	28.99	13.08	12	29282	872	63458856
Psoriasis	28.81	13.08	97	29197	86860	63372868
Surgery	28.79	13.08	56	29238	35856	63423872
Suicide attempt	28.75	13.08	77	29217	60841	63398887
Anger	28.70	13.08	32	29262	12424	63447304
Rheumatoid arthritis	28.21	13.08	46	29248	253773	63205955
Helicobacter infection	27.10	13.08	5	29289	92780	63366948
Injection site mass	27.05	13.08	38	29256	18618	63441110
Extrapyramidal disorder	27.03	13.08	32	29262	13252	63446476
Sporotrichosis	26.82	13.08	6	29288	49	63459679
Anaemia	26.66	13.08	60	29234	293370	63166358
Therapeutic product effect decreased	26.53	13.08	30	29264	193157	63266571
Alcoholism	26.25	13.08	14	29280	1804	63457924
Poisoning	26.23	13.08	32	29262	13668	63446060
Neuroleptic malignant syndrome	26.13	13.08	30	29264	12026	63447702
Product administration interrupted	26.10	13.08	20	29274	4816	63454912
Multiple sclerosis	25.94	13.08	43	29251	24329	63435399
False positive investigation result	25.33	13.08	10	29284	643	63459085
Impaired healing	25.12	13.08	8	29286	102534	63357194
Device expulsion	25.06	13.08	52	29242	34870	63424858
Bipolar disorder	24.73	13.08	24	29270	7936	63451792
Therapy interrupted	24.08	13.08	49	29245	32406	63427322
Foreign body in reproductive tract	23.85	13.08	10	29284	751	63458977
Mydriasis	23.01	13.08	28	29266	11928	63447800
Pancytopenia	22.98	13.08	8	29286	96925	63362803
Sleep apnoea syndrome	22.83	13.08	45	29249	29088	63430640
Plasma cell mastitis	22.55	13.08	5	29289	39	63459689
Device breakage	22.16	13.08	27	29267	11515	63448213
Illness	22.13	13.08	61	29233	48998	63410730
Memory impairment	22.07	13.08	101	29193	104157	63355571
Blister	21.52	13.08	17	29277	129797	63329931
Panic disorder	21.44	13.08	14	29280	2619	63457109
Hypersensitivity	21.16	13.08	67	29227	292618	63167110
Maternal exposure during pregnancy	20.80	13.08	44	29250	220018	63239710
Myofascial pain syndrome	20.54	13.08	13	29281	2305	63457423
Diabetic neuropathy	20.53	13.08	16	29278	3948	63455780
C-reactive protein increased	20.50	13.08	9	29285	94698	63365030
Irritability	20.22	13.08	45	29249	31649	63428079
Depressed mood	20.18	13.08	52	29242	40139	63419589
Hospitalisation	19.96	13.08	85	29209	84996	63374732
Tardive dyskinesia	19.86	13.08	22	29272	8480	63451248
Abnormal uterine bleeding	19.81	13.08	11	29283	1535	63458193
Parkinsonism	19.37	13.08	24	29270	10415	63449313
Generalised anxiety disorder	19.31	13.08	12	29282	2062	63457666
Interstitial lung disease	18.82	13.08	3	29291	61905	63397823
Dental restoration failure	18.31	13.08	9	29285	978	63458750
Respiratory arrest	18.24	13.08	44	29250	32601	63427127
Autonomic nervous system imbalance	18.23	13.08	13	29281	2805	63456923
Delusion	18.20	13.08	25	29269	11992	63447736
Affective disorder	18.11	13.08	18	29276	6128	63453600
Exposure via ingestion	17.86	13.08	13	29281	2896	63456832
Bruxism	17.77	13.08	14	29280	3511	63456217
Somnambulism	17.76	13.08	17	29277	5526	63454202
Syndactyly	17.58	13.08	7	29287	460	63459268
Blood bicarbonate abnormal	17.44	13.08	4	29290	37	63459691
Cerebellar infarction	17.09	13.08	11	29283	2008	63457720
Intentional self-injury	16.98	13.08	37	29257	25650	63434078
Hallucination, auditory	16.95	13.08	25	29269	12799	63446929
Stress cardiomyopathy	16.38	13.08	21	29273	9429	63450299
Fall	16.38	13.08	263	29031	392071	63067657
Rhabdomyolysis	16.33	13.08	51	29243	43900	63415828
Inflammation	16.02	13.08	9	29285	82264	63377464
Headache	15.86	13.08	393	28901	632848	62826880
Major depression	15.79	13.08	19	29275	7999	63451729
Stress	15.67	13.08	67	29227	67100	63392628
Laryngeal granuloma	15.65	13.08	3	29291	10	63459718
Exposure during pregnancy	15.63	13.08	30	29264	155517	63304211
Cleft lip and palate	15.51	13.08	7	29287	628	63459100
Nightmare	15.47	13.08	30	29264	19164	63440564
Mobility decreased	15.37	13.08	20	29274	121139	63338589
Depressed level of consciousness	15.32	13.08	63	29231	62015	63397713
Muscle necrosis	15.17	13.08	7	29287	661	63459067
Dyspareunia	15.14	13.08	11	29283	2444	63457284
Flat affect	15.06	13.08	9	29285	1441	63458287
Hyperhidrosis	14.96	13.08	93	29201	107743	63351985
Therapy cessation	14.87	13.08	39	29255	30418	63429310
Post-traumatic stress disorder	14.77	13.08	15	29279	5236	63454492
Haemoglobin decreased	14.67	13.08	28	29266	145457	63314271
Muscle rigidity	14.60	13.08	22	29272	11478	63448250
Injection site pain	14.45	13.08	106	29188	129694	63330034
Blood pressure orthostatic	14.40	13.08	4	29290	84	63459644
Long QT syndrome	14.37	13.08	12	29282	3267	63456461
Mood altered	14.35	13.08	25	29269	14718	63445010
Thunderclap headache	14.35	13.08	5	29289	226	63459502
Presbyopia	14.13	13.08	6	29288	465	63459263
Renal impairment	14.11	13.08	12	29282	88343	63371385
Anhedonia	13.94	13.08	21	29273	10953	63448775
Akathisia	13.81	13.08	19	29275	9127	63450601
Restless legs syndrome	13.77	13.08	28	29266	18503	63441225
Alcohol withdrawal syndrome	13.75	13.08	7	29287	820	63458908
Embedded device	13.74	13.08	12	29282	3471	63456257
Injection site reaction	13.36	13.08	58	29236	58466	63401262
Complication of device removal	13.23	13.08	14	29280	5128	63454600
Social avoidant behaviour	13.23	13.08	11	29283	2977	63456751
Anticholinergic syndrome	13.18	13.08	10	29284	2372	63457356
Bradykinesia	13.12	13.08	14	29280	5174	63454554

FDA Adverse Event Reporting System (Male)

MedDRA adverse event term	Likelihood ratio	Likelihood ratio threshold	Patients taking drug having adverse event	Patients taking drug not having adverse event	Patients not taking drug having adverse event	Patients not taking drug not having adverse event
Completed suicide	152.17	16.35	162	9743	98006	34849020
Sedation	126.33	16.35	77	9828	20929	34926097
Serotonin syndrome	104.56	16.35	67	9838	19866	34927160
Suicidal ideation	89.21	16.35	81	9824	40307	34906719
Anxiety	85.43	16.35	122	9783	99306	34847720
Tardive dyskinesia	76.89	16.35	36	9869	5754	34941272
Irritability	65.52	16.35	55	9850	24635	34922391
Agitation	62.32	16.35	79	9826	57320	34889706
Depression	43.19	16.35	89	9816	97009	34850017
Neuroleptic malignant syndrome	41.59	16.35	37	9868	17897	34929129
Wrong patient	38.95	16.35	9	9896	146	34946880
Tremor	37.07	16.35	76	9829	82511	34864515
Aggression	36.64	16.35	50	9855	38914	34908112
Withdrawal syndrome	35.64	16.35	29	9876	12426	34934600
Electrocardiogram QRS complex prolonged	34.78	16.35	20	9885	4874	34942152
Muscle necrosis	30.84	16.35	11	9894	875	34946151
Obesity	30.71	16.35	27	9878	12851	34934175
Toxicity to various agents	29.88	16.35	124	9781	200238	34746788
Product dose omission issue	28.07	16.35	86	9819	119625	34827401
Insomnia	27.56	16.35	78	9827	103829	34843197
Seizure	27.11	16.35	78	9827	104779	34842247
Drug abuse	25.90	16.35	74	9831	99022	34848004
Orthostatic tremor	25.01	16.35	4	9901	6	34947020
Nightmare	24.43	16.35	25	9880	14366	34932660
General physical health deterioration	23.57	16.35	4	9901	128265	34818761
Pneumonia	23.36	16.35	42	9863	362585	34584441
Hypoparathyroidism	22.92	16.35	8	9897	597	34946429
Anger	22.68	16.35	22	9883	11862	34935164
Orthostatic hypotension	22.47	16.35	32	9873	25887	34921139
Therapy interrupted	21.83	16.35	23	9882	13674	34933352
Feeling abnormal	21.38	16.35	52	9853	63183	34883843
Drug withdrawal syndrome	21.02	16.35	27	9878	19807	34927219
Lens dislocation	20.33	16.35	5	9900	107	34946919
Electrocardiogram QT prolonged	19.92	16.35	39	9866	40913	34906113
Febrile neutropenia	19.84	16.35	7	9898	136842	34810184
Thrombocytopenia	19.45	16.35	10	9895	156237	34790789
Alcoholism	18.14	16.35	11	9894	2954	34944072
Microvascular coronary artery disease	18.14	16.35	4	9901	52	34946974
Akathisia	17.36	16.35	16	9889	8093	34938933
Acute kidney injury	17.32	16.35	38	9867	304950	34642076
Panic attack	17.14	16.35	17	9888	9415	34937611
Post-traumatic stress disorder	16.98	16.35	9	9896	1872	34945154
Hypertensive urgency	16.85	16.35	5	9900	221	34946805
Pre-existing condition improved	16.85	16.35	10	9895	2582	34944444

FDA Adverse Event Reporting System (Geriatric)

MedDRA adverse event term	Likelihood ratio	Likelihood ratio threshold	Patients taking drug having adverse event	Patients taking drug not having adverse event	Patients not taking drug having adverse event	Patients not taking drug not having adverse event
Completed suicide	687.67	12.55	643	30117	245124	79468504
Serotonin syndrome	309.10	12.55	201	30559	44826	79668802
Suicidal ideation	137.16	12.55	158	30602	76182	79637446
Anxiety	128.62	12.55	291	30469	248221	79465407
Toxicity to various agents	127.24	12.55	404	30356	421136	79292492
Depression	111.18	12.55	253	30507	216537	79497091
Withdrawal syndrome	85.89	12.55	76	30684	26778	79686850
Agitation	83.42	12.55	143	30617	99572	79614056
Product dose omission issue	67.98	12.55	230	30530	247307	79466321
Tremor	65.48	12.55	178	30582	169905	79543723
Neuroleptic malignant syndrome	65.19	12.55	66	30694	27493	79686135
Irritability	57.40	12.55	75	30685	41069	79672559
Insomnia	55.56	12.55	214	30546	244956	79468672
General physical health deterioration	54.60	12.55	19	30741	275219	79438409
Tardive dyskinesia	53.16	12.55	39	30721	10532	79703096
Febrile neutropenia	51.18	12.55	13	30747	230986	79482642
Sedation	50.91	12.55	80	30680	51815	79661813
Thrombocytopenia	49.78	12.55	20	30740	265239	79448389
Overdose	49.51	12.55	170	30590	184036	79529592
Suspected suicide	48.68	12.55	37	30723	10539	79703089
Dermatitis atopic	48.10	12.55	36	30724	10020	79703608
Panic attack	46.65	12.55	52	30708	24164	79689464
Drug abuse	45.35	12.55	152	30608	162539	79551089
Muscle necrosis	44.95	12.55	18	30742	1440	79712188
Intentional overdose	44.93	12.55	115	30645	105845	79607783
Pancytopenia	43.79	12.55	6	30754	165739	79547889
Drug withdrawal syndrome	40.44	12.55	58	30702	34660	79678968
Neutropenia	39.29	12.55	32	30728	287678	79425950
Anaemia	39.04	12.55	70	30690	444945	79268683
Stiff person syndrome	38.45	12.55	11	30749	311	79713317
Injection site mass	38.29	12.55	43	30717	20141	79693487
Anger	36.80	12.55	39	30721	17123	79696505
Alcoholism	36.78	12.55	21	30739	3702	79709926
Contraindicated product administered	36.59	12.55	8	30752	157530	79556098
Drug intolerance	36.53	12.55	29	30731	264090	79449538
Mydriasis	35.91	12.55	39	30721	17604	79696024
Akathisia	35.53	12.55	34	30726	13225	79700403
Cardio-respiratory arrest	35.36	12.55	107	30653	108403	79605225
Drug screen false positive	35.27	12.55	14	30746	1095	79712533
Renal impairment	34.70	12.55	9	30751	157774	79555854
Anoxia	32.88	12.55	10	30750	351	79713277
Migraine	32.08	12.55	90	30670	87403	79626225
Feeling abnormal	32.05	12.55	134	30626	159065	79554563
Nightmare	31.29	12.55	44	30716	25817	79687811
Total cholesterol/HDL ratio abnormal	30.58	12.55	7	30753	78	79713550
Synovitis	30.58	12.55	10	30750	150724	79562904
Emotional disorder	29.63	12.55	32	30728	14355	79699273
Lower respiratory tract infection	29.13	12.55	7	30753	129213	79584415
Behaviour disorder	28.86	12.55	22	30738	6291	79707337
Depressed mood	28.68	12.55	60	30700	48420	79665208
Treatment failure	28.63	12.55	15	30745	170471	79543157
Somnolence	28.20	12.55	173	30587	238808	79474820
Delusion	28.13	12.55	37	30723	20386	79693242
Electrocardiogram QRS complex prolonged	27.57	12.55	27	30733	10806	79702822
Suicide attempt	27.22	12.55	82	30678	82850	79630778
Device expulsion	26.94	12.55	41	30719	25820	79687808
Hand deformity	26.89	12.55	4	30756	103915	79609713
Foreign body in reproductive tract	26.80	12.55	10	30750	661	79712967
Wound	26.77	12.55	6	30754	116173	79597455
Glossodynia	26.69	12.55	4	30756	103333	79610295
Mental status changes	26.66	12.55	71	30689	66888	79646740
Therapy interrupted	26.25	12.55	45	30715	31296	79682332
Hyperkalaemia	26.18	12.55	6	30754	114392	79599236
Respiratory arrest	25.99	12.55	64	30696	57486	79656142
Parkinsonism	25.93	12.55	32	30728	16552	79697076
Injection site reaction	25.89	12.55	62	30698	54723	79658905
Mental disorder	24.99	12.55	44	30716	31258	79682370
Device breakage	24.21	12.55	25	30735	10650	79702978
Infusion related reaction	24.20	12.55	32	30728	230205	79483423
C-reactive protein increased	23.75	12.55	10	30750	129017	79584611
Surgery	23.54	12.55	44	30716	32722	79680906
Generalised anxiety disorder	23.35	12.55	13	30747	2184	79711444
Attention deficit hyperactivity disorder	23.24	12.55	15	30745	3294	79710334
Pre-existing condition improved	22.43	12.55	18	30742	5545	79708083
Extrapyramidal disorder	22.29	12.55	35	30725	22644	79690984
Hypothermia	22.21	12.55	35	30725	22711	79690917
False positive investigation result	21.92	12.55	10	30750	1102	79712526
Interstitial lung disease	21.92	12.55	8	30752	112592	79601036
Seizure	21.82	12.55	136	30624	188698	79524930
Memory impairment	21.67	12.55	93	30667	111641	79601987
Intentional self-injury	21.40	12.55	42	30718	32377	79681251
Injection site pain	21.40	12.55	103	30657	129735	79583893
Disturbance in attention	21.38	12.55	55	30705	50746	79662882
Joint swelling	21.37	12.55	50	30710	288596	79425032
Fall	20.85	12.55	283	30477	487346	79226282
Poisoning	20.79	12.55	36	30724	25236	79688392
Injection site induration	20.50	12.55	22	30738	9797	79703831
Wrong patient	20.43	12.55	7	30753	361	79713267
Pyrexia	20.32	12.55	166	30594	678543	79035085
Arthropathy	20.31	12.55	23	30737	177088	79536540
Headache	19.80	12.55	358	30402	653414	79060214
Anticholinergic syndrome	19.70	12.55	14	30746	3597	79710031
Orthostatic tremor	19.53	12.55	4	30756	25	79713603
Mucosal inflammation	19.34	12.55	3	30757	75577	79638051
Psoriasis	19.28	12.55	77	30683	89510	79624118
Vision blurred	18.91	12.55	86	30674	105812	79607816
Myofascial pain syndrome	18.82	12.55	11	30749	2026	79711602
Flat affect	18.80	12.55	11	30749	2030	79711598
Muscle twitching	18.73	12.55	34	30726	24730	79688898
Plasma cell mastitis	18.56	12.55	4	30756	33	79713595
Haemoglobin decreased	18.50	12.55	36	30724	222083	79491545
Hepatic function abnormal	18.49	12.55	3	30757	73104	79640524
Stress cardiomyopathy	18.19	12.55	22	30738	11144	79702484
Weight increased	18.17	12.55	175	30585	277211	79436417
Swelling	18.16	12.55	35	30725	216676	79496952
Pleural effusion	17.62	12.55	18	30742	145244	79568384
Hypertensive urgency	17.59	12.55	7	30753	551	79713077
Hepatic enzyme increased	17.58	12.55	27	30733	182583	79531045
Accidental exposure to product by child	17.50	12.55	12	30748	2914	79710714
Malignant neoplasm progression	17.48	12.55	16	30744	135974	79577654
Impaired healing	17.45	12.55	6	30754	87649	79625979
Panic disorder	17.26	12.55	12	30748	2980	79710648
Therapeutic response unexpected	17.18	12.55	29	30731	19917	79693711
Presbyopia	17.12	12.55	7	30753	591	79713037
Hallucination	17.11	12.55	72	30688	85673	79627955
Lens dislocation	17.04	12.55	5	30755	155	79713473
Laryngeal granuloma	16.97	12.55	3	30757	7	79713621
Ideas of reference	16.74	12.55	5	30755	165	79713463
Complication of device removal	16.58	12.55	13	30747	3876	79709752
Aggression	16.35	12.55	50	30710	50908	79662720
Therapy cessation	16.15	12.55	41	30719	37521	79676107
Embedded device	16.14	12.55	12	30748	3307	79710321
Blood bilirubin increased	16.13	12.55	3	30757	66229	79647399
Drug-induced liver injury	16.09	12.55	3	30757	66114	79647514
Tachyphrenia	16.03	12.55	10	30750	2070	79711558
Muscle rigidity	15.94	12.55	28	30732	19854	79693774
Hypoparathyroidism	15.93	12.55	8	30752	1090	79712538
Antisocial behaviour	15.86	12.55	7	30753	714	79712914
Bipolar disorder	15.62	12.55	17	30743	7690	79705938
Euphoric mood	15.58	12.55	17	30743	7709	79705919
Feeling of despair	15.54	12.55	11	30749	2810	79710818
Rheumatoid arthritis	15.51	12.55	36	30724	208434	79505194
Ascites	15.34	12.55	5	30755	75557	79638071
Exposure via ingestion	15.27	12.55	14	30746	5160	79708468
Device dislocation	15.19	12.55	32	30728	25938	79687690
Rhabdomyolysis	15.01	12.55	79	30681	103052	79610576
Dizziness	14.78	12.55	285	30475	526156	79187472
Systemic lupus erythematosus	14.70	12.55	15	30745	121134	79592494
Product administered at inappropriate site	14.25	12.55	12	30748	3953	79709675
Platelet count decreased	14.18	12.55	34	30726	194630	79518998
Therapeutic product effect decreased	14.13	12.55	26	30734	163837	79549791
Gynaecomastia	13.95	12.55	16	30744	7665	79705963
Dental restoration failure	13.78	12.55	7	30753	977	79712651
Disease progression	13.59	12.55	32	30728	184330	79529298
Helicobacter infection	13.48	12.55	5	30755	69699	79643929
Depressed level of consciousness	13.36	12.55	73	30687	96579	79617049
Hallucination, visual	13.32	12.55	35	30725	32694	79680934
Hyperhidrosis	13.29	12.55	102	30658	151390	79562238
Abnormal uterine bleeding	13.21	12.55	7	30753	1066	79712562
Blister	13.17	12.55	16	30744	119460	79594168
Tension	13.16	12.55	12	30748	4392	79709236
Pupillary deformity	13.14	12.55	3	30757	33	79713595
Blood bicarbonate abnormal	13.11	12.55	4	30756	142	79713486
Diabetic neuropathy	13.10	12.55	14	30746	6202	79707426
Cerebellar infarction	13.03	12.55	11	30749	3636	79709992
Injection site abscess	12.93	12.55	8	30752	1632	79711996
Aspartate aminotransferase increased	12.87	12.55	21	30739	138620	79575008
Complication of device insertion	12.86	12.55	14	30746	6336	79707292
Psychotic disorder	12.71	12.55	40	30720	41362	79672266
Hallucination, auditory	12.69	12.55	26	30734	20667	79692961
Hypersensitivity	12.68	12.55	55	30705	262184	79451444

FDA Adverse Event Reporting System (Pediatric)

None

Pharmacologic Action:

Source	Code	Description
ATC	N05BE01	NERVOUS SYSTEM PSYCHOLEPTICS ANXIOLYTICS Azaspirodecanedione derivatives
CHEBI has role	CHEBI:35474	anti-anxiety agents
CHEBI has role	CHEBI:35717	hypnotics
CHEBI has role	CHEBI:35941	serotonin agonists
CHEBI has role	CHEBI:76779	post-proline endopeptidase inhibitors
MeSH PA	D014151	Anti-Anxiety Agents
MeSH PA	D002491	Central Nervous System Agents
MeSH PA	D002492	Central Nervous System Depressants
MeSH PA	D018377	Neurotransmitter Agents
MeSH PA	D011619	Psychotropic Drugs
MeSH PA	D018490	Serotonin Agents
MeSH PA	D017366	Serotonin Receptor Agonists
MeSH PA	D014149	Tranquilizing Agents

Drug Use | Suggest Off label Use Form| |View source of the data|

Disease	Relation	SNOMED_ID	DOID
Generalized anxiety disorder	indication	21897009	DOID:14320
Acute nephropathy	contraindication	58574008
Hepatic failure	contraindication	59927004

🐶 Veterinary Drug Use

None

🐶 Veterinary products

None

Acid dissociation constants calculated using MoKa v3.0.0

Dissociation level	Dissociation constant	Type (acidic/basic)
pKa1	7.51	Basic
pKa2	2.23	Basic

Orange Book patent data (new drug applications)

None

Orange Book exclusivity data (new drug applications)

None

Bioactivity Summary:

Target	Class	Pharos	UniProt	Action	Type	Activity value (-log[M])	Bioact source	MoA source
5-hydroxytryptamine receptor 1A	GPCR	P08908	5HT1A_HUMAN	PARTIAL AGONIST	EC50	7.25	WOMBAT-PK	CHEMBL
D(2) dopamine receptor	GPCR	P14416	DRD2_HUMAN		Ki	7.68	WOMBAT-PK
Sigma non-opioid intracellular receptor 1	Membrane receptor	Q99720	SGMR1_HUMAN		Ki	7.32	WOMBAT-PK
Potassium voltage-gated channel subfamily H member 2	Ion channel	Q12809	KCNH2_HUMAN		IC50	5.40	CHEMBL
Cytochrome P450 3A4	Enzyme	P08684	CP3A4_HUMAN		Ki	5.13	WOMBAT-PK
5-hydroxytryptamine receptor 2A	GPCR	P28223	5HT2A_HUMAN		Ki	6.60	WOMBAT-PK
5-hydroxytryptamine receptor 2B	GPCR	P41595	5HT2B_HUMAN		Ki	6.41	WOMBAT-PK
5-hydroxytryptamine receptor 2C	GPCR	P28335	5HT2C_HUMAN		Ki	6.04	WOMBAT-PK
5-hydroxytryptamine receptor 7	GPCR	P34969	5HT7R_HUMAN		Ki	6.08	CHEMBL
Alpha-1A adrenergic receptor	GPCR	P35348	ADA1A_HUMAN		Ki	6.44	WOMBAT-PK
D(3) dopamine receptor	GPCR	P35462	DRD3_HUMAN		Ki	6.18	CHEMBL
D(4) dopamine receptor	GPCR	P21917	DRD4_HUMAN		Ki	7	WOMBAT-PK
Alpha-1D adrenergic receptor	GPCR	P25100	ADA1D_HUMAN		Ki	6.28	DRUG MATRIX
Solute carrier family 22 member 2	Transporter	O15244	S22A2_HUMAN		IC50	4.92	CHEMBL
Multidrug and toxin extrusion protein 1	Transporter	Q96FL8	S47A1_HUMAN		IC50	5.77	CHEMBL
Multidrug and toxin extrusion protein 2	Transporter	Q86VL8	S47A2_HUMAN		IC50	4.34	CHEMBL
5-hydroxytryptamine receptor 1B	GPCR		5HT1B_RAT		Ki	7.77	CHEMBL
Membrane-associated progesterone receptor component 1	Membrane receptor		PGRC1_RAT		IC50	5.47	DRUG MATRIX
D(2) dopamine receptor	GPCR		DRD2_RAT		Ki	6.92	CHEMBL
5-hydroxytryptamine receptor 1A	GPCR		5HT1A_RAT		Ki	8.42	CHEMBL
5-hydroxytryptamine receptor 2A	GPCR		5HT2A_RAT		Ki	6.32	CHEMBL
Sigma non-opioid intracellular receptor 1	Membrane receptor		SGMR1_RAT		Ki	7.32	CHEMBL
5-hydroxytryptamine receptor 7	GPCR		5HT7R_RAT	AGONIST	Ki	6.40	IUPHAR
5-hydroxytryptamine receptor 7	GPCR		5HT7R_MOUSE	ANTAGONIST	Ki	6.40	IUPHAR
D(1A) dopamine receptor	GPCR		DRD1_BOVIN		Ki	5.21	CHEMBL
D(2) dopamine receptor	GPCR		DRD2_BOVIN		Ki	7.36	CHEMBL
5-hydroxytryptamine receptor 2C	GPCR		5HT2C_RAT		IC50	6	CHEMBL
Alpha-2A adrenergic receptor	GPCR		ADA2A_BOVIN		IC50	5	CHEMBL
5-hydroxytryptamine receptor 2A	GPCR		5HT2A_BOVIN		Ki	6.75	CHEMBL
Serotonin 1 (5-HT1) receptor	GPCR		5HT1A_RAT 5HT1B_RAT 5HT1D_RAT 5HT1F_RAT		IC50	7.02	CHEMBL
Adrenergic receptor alpha-2	GPCR		ADA2B_RAT ADA2C_RAT ADA2A_RAT		IC50	5	CHEMBL
Dopamine receptor	GPCR		DRD1_RAT DRD3_RAT DRD5_RAT DRD4_RAT DRD2_RAT		IC50	6.92	CHEMBL
Adrenergic receptor alpha-1	GPCR		ADA1B_RAT ADA1D_RAT ADA1A_RAT		Ki	6.86	CHEMBL
Alpha-1A adrenergic receptor	GPCR		ADA1A_BOVIN		IC50	4.80	CHEMBL
Serotonin 2 (5-HT2) receptor	GPCR		5HT2C_RAT 5HT2A_RAT 5HT2B_RAT		Ki	6.76	CHEMBL

External reference:

ID	Source
4019646	VUID
N0000147739	NUI
D00702	KEGG_DRUG
33386-08-2	SECONDARY_CAS_RN
1827	RXNORM
C0006462	UMLSCUI
CHEBI:3223	CHEBI
CHEMBL49	ChEMBL_ID
DB00490	DRUGBANK_ID
CHEMBL1200399	ChEMBL_ID
D002065	MESH_DESCRIPTOR_UI
2477	PUBCHEM_CID
36	IUPHAR_LIGAND_ID
3456	INN_ID
TK65WKS8HL	UNII
37673	MMSL
4308	MMSL
d00182	MMSL
387523009	SNOMEDCT_US
419484002	SNOMEDCT_US
91452003	SNOMEDCT_US
4018813	VANDF
4019646	VANDF
001468	NDDF
004586	NDDF

Pharmaceutical products:

Product	Category	Ingredients	NDC	Form	Quantity	Route	Marketing	Label
Buspirone Hydrochloride	HUMAN PRESCRIPTION DRUG LABEL	1	0093-0053	TABLET	5 mg	ORAL	ANDA	29 sections
Buspirone Hydrochloride	HUMAN PRESCRIPTION DRUG LABEL	1	0093-0053	TABLET	5 mg	ORAL	ANDA	29 sections
Buspirone Hydrochloride	HUMAN PRESCRIPTION DRUG LABEL	1	0093-0054	TABLET	10 mg	ORAL	ANDA	29 sections
Buspirone Hydrochloride	HUMAN PRESCRIPTION DRUG LABEL	1	0093-0054	TABLET	10 mg	ORAL	ANDA	29 sections
Buspirone Hydrochloride	HUMAN PRESCRIPTION DRUG LABEL	1	0093-1003	TABLET	15 mg	ORAL	ANDA	29 sections
Buspirone Hydrochloride	HUMAN PRESCRIPTION DRUG LABEL	1	0093-1003	TABLET	15 mg	ORAL	ANDA	29 sections
Buspirone Hydrochloride	HUMAN PRESCRIPTION DRUG LABEL	1	0093-5200	TABLET	30 mg	ORAL	ANDA	29 sections
Buspirone Hydrochloride	HUMAN PRESCRIPTION DRUG LABEL	1	0093-5200	TABLET	30 mg	ORAL	ANDA	29 sections
Buspirone Hydrochloride	HUMAN PRESCRIPTION DRUG LABEL	1	0378-1140	TABLET	5 mg	ORAL	ANDA	27 sections
Buspirone Hydrochloride	HUMAN PRESCRIPTION DRUG LABEL	1	0378-1140	TABLET	5 mg	ORAL	ANDA	27 sections
Buspirone Hydrochloride	HUMAN PRESCRIPTION DRUG LABEL	1	0378-1145	TABLET	7.50 mg	ORAL	ANDA	27 sections
Buspirone Hydrochloride	HUMAN PRESCRIPTION DRUG LABEL	1	0378-1145	TABLET	7.50 mg	ORAL	ANDA	27 sections
Buspirone Hydrochloride	HUMAN PRESCRIPTION DRUG LABEL	1	0378-1150	TABLET	10 mg	ORAL	ANDA	27 sections
Buspirone Hydrochloride	HUMAN PRESCRIPTION DRUG LABEL	1	0378-1150	TABLET	10 mg	ORAL	ANDA	27 sections
Buspirone Hydrochloride	HUMAN PRESCRIPTION DRUG LABEL	1	0378-1165	TABLET	15 mg	ORAL	ANDA	27 sections
Buspirone Hydrochloride	HUMAN PRESCRIPTION DRUG LABEL	1	0378-1165	TABLET	15 mg	ORAL	ANDA	27 sections
Buspirone Hydrochloride	HUMAN PRESCRIPTION DRUG LABEL	1	0378-1175	TABLET	30 mg	ORAL	ANDA	27 sections
Buspirone Hydrochloride	HUMAN PRESCRIPTION DRUG LABEL	1	0378-1175	TABLET	30 mg	ORAL	ANDA	27 sections
Buspirone Hydrochloride	HUMAN PRESCRIPTION DRUG LABEL	1	0615-4575	TABLET	10 mg	ORAL	ANDA	29 sections
Buspirone Hydrochloride	HUMAN PRESCRIPTION DRUG LABEL	1	0615-4595	TABLET	5 mg	ORAL	ANDA	29 sections
Buspirone Hydrochloride	HUMAN PRESCRIPTION DRUG LABEL	1	0615-4596	TABLET	15 mg	ORAL	ANDA	29 sections
Buspirone Hydrochloride	HUMAN PRESCRIPTION DRUG LABEL	1	0615-7633	TABLET	5 mg	ORAL	ANDA	30 sections
Buspirone Hydrochloride	HUMAN PRESCRIPTION DRUG LABEL	1	0615-7634	TABLET	10 mg	ORAL	ANDA	30 sections
Buspirone Hydrochloride	HUMAN PRESCRIPTION DRUG LABEL	1	0615-7635	TABLET	15 mg	ORAL	ANDA	30 sections
Buspirone Hydrochloride	HUMAN PRESCRIPTION DRUG LABEL	1	0615-7689	TABLET	15 mg	ORAL	ANDA	30 sections
Buspirone Hydrochloride	HUMAN PRESCRIPTION DRUG LABEL	1	0615-7689	TABLET	15 mg	ORAL	ANDA	30 sections
Buspirone Hydrochloride	HUMAN PRESCRIPTION DRUG LABEL	1	0615-7714	TABLET	5 mg	ORAL	ANDA	30 sections
Buspirone Hydrochloride	HUMAN PRESCRIPTION DRUG LABEL	1	0615-7714	TABLET	5 mg	ORAL	ANDA	30 sections
Buspirone Hydrochloride	HUMAN PRESCRIPTION DRUG LABEL	1	0615-7718	TABLET	10 mg	ORAL	ANDA	30 sections
Buspirone Hydrochloride	HUMAN PRESCRIPTION DRUG LABEL	1	0615-7718	TABLET	10 mg	ORAL	ANDA	30 sections