buspirone 🐶 Veterinary Use | Indications/Contra | FAERs-F | FAERs-M | Orange Bk | PK/Tox | Related Drugs | BioActivity |

Stem definitionDrug idCAS RN
anxiolytics, buspirone derivatives 437 36505-84-7

Description:

MoleculeDescription

Molfile Inchi Smiles

Synonyms:

  • buspirone
  • buspin
  • buspirone hydrochloride
  • buspirone HCl
An anxiolytic agent and serotonin receptor agonist belonging to the azaspirodecanedione class of compounds. Its structure is unrelated to those of the BENZODIAZAPINES, but it has an efficacy comparable to DIAZEPAM.
  • Molecular weight: 385.51
  • Formula: C21H31N5O2
  • CLOGP: 2.24
  • LIPINSKI: 0
  • HAC: 7
  • HDO: 0
  • TPSA: 69.64
  • ALOGS: -2.82
  • ROTB: 6
  • Status: OFP
    • Legend:
    OFP - off patent
    OFM - off market
    ONP - on patent

Drug dosage:

DoseUnitRoute
30 mg O

ADMET properties:

PropertyValueReference
BDDCS (Biopharmaceutical Drug Disposition Classification System) 2 Benet LZ, Broccatelli F, Oprea TI
S (Water solubility) 0.02 mg/mL Benet LZ, Broccatelli F, Oprea TI
EoM (Fraction excreted unchanged in urine) 0.10 % Benet LZ, Broccatelli F, Oprea TI
MRTD (Maximum Recommended Therapeutic Daily Dose) 2.59 µM/kg/day Contrera JF, Matthews EJ, Kruhlak NL, Benz RD
BA (Bioavailability) 3.90 % Kim MT, Sedykh A, Chakravarti SK, Saiakhov RD, Zhu H

Predicted pharmacokinetic/toxicological properties (PK-AZ):

PropertyDescriptionValueUnitConfidenceSimilarity
kinase-safety-class ACVR2B,AXL,BRAF,CAMK2D,CDK5,CDK9,EIF2AK3,EPHB4,ERBB2,GRK2,MAPK7,NTRK2,PDK2,PDK4,PRKDC,SIK2,TEK 17
kinase-selectivity-class AXL,ERBB2,GRK2,STK33,TTK 5
mdck-mdr1-bcrp-efflux MDCK-MDR1-BCRP efflux ratio 0.387 High 1
pfas-class PFAS structural alert (1 = True, 0 = False) 0
pld-class Phospholipidosis risk class (1 = positive, 0 = negative) 1 High 1
rat-kpuu-brain Rat brain Kpuu 0.191 % High 1

Approvals:

DateAgencyCompanyOrphan
Sept. 29, 1986 FDA

FDA Adverse Event Reporting System (Female)

MedDRA adverse event termLikelihood ratioLikelihood ratio thresholdPatients taking drug having adverse eventPatients taking drug not having adverse eventPatients not taking drug having adverse eventPatients not taking drug not having adverse event
Completed suicide 814.11 12.22 605 39943 144453 90443446
Serotonin syndrome 318.40 12.22 203 40345 37684 90550215
Suicidal ideation 242.04 12.22 226 40322 73629 90514270
Depression 171.35 12.22 400 40148 300201 90287698
Anxiety 163.41 12.22 400 40148 309372 90278527
Product dose omission issue 159.56 12.22 382 40166 291305 90296594
Dermatitis atopic 145.07 12.22 104 40444 23368 90564531
Toxicity to various agents 137.45 12.22 358 40190 287488 90300411
Product administration interrupted 133.25 12.22 78 40470 12414 90575485
Glossodynia 129.60 12.22 3 40545 321776 90266123
Synovitis 116.46 12.22 8 40540 329744 90258155
Hand deformity 111.41 12.22 5 40543 296357 90291542
Contraindicated product administered 106.83 12.22 10 40538 320129 90267770
Suspected suicide 97.48 12.22 58 40490 9510 90578389
Systemic lupus erythematosus 94.27 12.22 23 40525 361873 90226026
Infusion related reaction 91.54 12.22 36 40512 416744 90171155
Withdrawal syndrome 87.68 12.22 76 40472 22448 90565451
General physical health deterioration 84.24 12.22 27 40521 355088 90232811
Wound 83.44 12.22 17 40531 302963 90284936
Injection site pain 76.69 12.22 210 40338 173489 90414410
Impaired healing 76.32 12.22 8 40540 234191 90353708
Helicobacter infection 75.89 12.22 7 40541 226843 90361056
Drug intolerance 75.75 12.22 54 40494 447537 90140362
Arthropathy 75.04 12.22 35 40513 366207 90221692
Folliculitis 75.01 12.22 4 40544 204349 90383550
Intentional overdose 74.37 12.22 143 40405 93691 90494208
Hepatic enzyme increased 71.58 12.22 36 40512 360700 90227199
Tremor 71.44 12.22 189 40359 152984 90434915
Lower respiratory tract infection 69.14 12.22 14 40534 250645 90337254
Treatment failure 68.79 12.22 25 40523 303903 90283996
Cardio-respiratory arrest 66.51 12.22 109 40439 63031 90524868
Panic attack 66.49 12.22 70 40478 26295 90561604
Muscle injury 66.29 12.22 3 40545 176651 90411248
Disturbance in attention 63.24 12.22 91 40457 47018 90540881
Joint swelling 61.62 12.22 81 40467 503219 90084680
Feeling abnormal 60.19 12.22 188 40360 167047 90420852
Drug withdrawal syndrome 58.18 12.22 68 40480 28655 90559244
Bezoar 57.78 12.22 27 40521 2707 90585192
Swelling 57.08 12.22 62 40486 418996 90168903
Illness 56.65 12.22 118 40430 81851 90506048
COVID-19 56.39 12.22 185 40363 168658 90419241
Somnolence 55.99 12.22 213 40335 208871 90379028
Liver injury 55.12 12.22 6 40542 170561 90417338
Corneal reflex decreased 54.88 12.22 15 40533 306 90587593
Blister 51.23 12.22 25 40523 254973 90332926
Surgery 50.70 12.22 80 40468 44807 90543092
Depressed mood 49.28 12.22 84 40464 50138 90537761
Agitation 49.21 12.22 99 40449 66999 90520900
Suicide attempt 49.16 12.22 106 40442 75293 90512606
Stomatitis 47.94 12.22 32 40516 274666 90313233
Complication of device insertion 46.35 12.22 38 40510 10398 90577501
Sleep disorder due to general medical condition, insomnia type 45.75 12.22 3 40545 128691 90459208
Febrile neutropenia 45.45 12.22 8 40540 158341 90429558
Mobility decreased 45.41 12.22 28 40520 250706 90337193
Tardive dyskinesia 44.82 12.22 38 40510 10892 90577007
Dry skin 44.47 12.22 112 40436 87961 90499938
Dissociation 44.37 12.22 31 40517 6684 90581215
Pre-existing condition improved 44.15 12.22 35 40513 9134 90578765
Endocarditis enterococcal 43.80 12.22 12 40536 247 90587652
C-reactive protein increased 42.61 12.22 14 40534 181375 90406524
Drug abuse 41.87 12.22 105 40443 82242 90505657
Stress 41.61 12.22 104 40444 81291 90506608
Thrombocytopenia 41.11 12.22 21 40527 208704 90379195
Overdose 40.83 12.22 159 40389 157550 90430349
Product dose omission in error 40.63 12.22 48 40500 20455 90567444
Alopecia 39.81 12.22 103 40445 494968 90092931
Bursitis 39.23 12.22 6 40542 131648 90456251
Drug screen false positive 38.99 12.22 15 40533 928 90586971
Inflammation 38.22 12.22 16 40532 178576 90409323
Intentional dose omission 37.52 12.22 43 40505 17740 90570159
Ill-defined disorder 37.32 12.22 18 40530 184873 90403026
Respiratory syncytial virus test positive 37.32 12.22 15 40533 1043 90586856
Extrapyramidal disorder 37.10 12.22 41 40507 16262 90571637
Rheumatoid arthritis 36.99 12.22 66 40482 362548 90225351
Areflexia 36.84 12.22 22 40526 3631 90584268
Sleep apnoea syndrome 36.43 12.22 57 40491 31690 90556209
Neuroleptic malignant syndrome 36.15 12.22 39 40509 15057 90572842
Fall 35.91 12.22 351 40197 481459 90106440
Mental disorder 35.67 12.22 57 40491 32261 90555638
Mitral valve replacement 35.67 12.22 12 40536 503 90587396
Anger 35.62 12.22 37 40511 13683 90574216
Insomnia 35.45 12.22 263 40285 333211 90254688
Somnambulism 34.86 12.22 26 40522 6202 90581697
Injection site mass 34.64 12.22 46 40502 22044 90565855
Hallucination, auditory 34.34 12.22 39 40509 15936 90571963
Bipolar disorder 34.33 12.22 30 40518 8955 90578944
Anoxia 34.32 12.22 10 40538 259 90587640
Pulmonary fibrosis 34.17 12.22 4 40544 107499 90480400
Hypersensitivity 33.99 12.22 98 40450 454579 90133320
Maternal exposure during pregnancy 33.70 12.22 69 40479 359994 90227905
Hyperhidrosis 33.33 12.22 135 40413 136170 90451729
Respiratory arrest 33.05 12.22 56 40492 33255 90554644
Pupillary reflex impaired 32.83 12.22 18 40530 2527 90585372
Migraine 32.74 12.22 170 40378 190222 90397677
Therapeutic product effect decreased 32.58 12.22 46 40502 277525 90310374
Major depression 31.48 12.22 30 40518 10005 90577894
Emotional disorder 31.20 12.22 36 40512 14961 90572938
Hypothermia 30.10 12.22 36 40512 15539 90572360
Impaired quality of life 30.03 12.22 44 40504 23100 90564799
Neutropenia 29.79 12.22 34 40514 224870 90363029
Alcoholism 29.68 12.22 15 40533 1785 90586114
Total cholesterol/HDL ratio abnormal 29.63 12.22 7 40541 77 90587822
Device expulsion 29.59 12.22 60 40488 40826 90547073
Panic disorder 29.45 12.22 18 40530 3097 90584802
Joint range of motion decreased 29.27 12.22 12 40536 135631 90452268
Multiple sclerosis 29.22 12.22 48 40500 27792 90560107
Foreign body in reproductive tract 29.21 12.22 13 40535 1164 90586735
Hypercholesterolaemia 29.16 12.22 5 40543 100887 90487012
Hospitalisation 29.07 12.22 124 40424 127976 90459923
Generalised anxiety disorder 28.89 12.22 17 40531 2730 90585169
Therapy interrupted 28.79 12.22 67 40481 50041 90537858
Inappropriate schedule of product administration 28.69 12.22 138 40410 149795 90438104
Post-traumatic stress disorder 28.53 12.22 24 40524 6804 90581095
Stiff person syndrome 28.34 12.22 10 40538 484 90587415
Blood cholesterol increased 28.04 12.22 31 40517 207981 90379918
Plasma cell mastitis 27.94 12.22 6 40542 41 90587858
Anaemia 27.87 12.22 74 40474 352728 90235171
Irritable bowel syndrome 27.87 12.22 31 40517 207417 90380482
Product use in unapproved indication 27.54 12.22 250 40298 335986 90251913
Musculoskeletal pain 27.20 12.22 22 40526 171229 90416670
Pancytopenia 27.00 12.22 10 40538 120253 90467646
Peripheral venous disease 26.98 12.22 3 40545 83918 90503981
Gastrointestinal disorder 26.82 12.22 46 40502 256641 90331258
Irritability 26.60 12.22 53 40495 35609 90552290
Pyrexia 26.44 12.22 180 40368 660305 89927594
Sporotrichosis 26.39 12.22 6 40542 55 90587844
Poisoning 25.90 12.22 33 40515 15184 90572715
Grip strength decreased 25.86 12.22 5 40543 92571 90495328
Hallucination, tactile 25.56 12.22 9 40539 433 90587466
Aortic valve replacement 25.23 12.22 11 40537 938 90586961
Mood swings 24.92 12.22 38 40510 20664 90567235
Neurodermatitis 24.81 12.22 16 40532 3022 90584877
Secondary hypertension 24.76 12.22 8 40540 295 90587604
Nausea 24.05 12.22 658 39890 1109658 89478241
Bruxism 23.94 12.22 18 40530 4345 90583554
Generalised tonic-clonic seizure 23.82 12.22 50 40498 34853 90553046
False positive investigation result 23.74 12.22 10 40538 783 90587116
Sleep disorder due to a general medical condition 23.74 12.22 58 40490 44680 90543219
Intentional self-injury 23.59 12.22 45 40503 29289 90558610
Seizure 23.34 12.22 132 40416 152497 90435402
Social avoidant behaviour 23.12 12.22 16 40532 3397 90584502
Drug interaction 22.86 12.22 206 40342 276247 90311652
Skin exfoliation 22.28 12.22 74 40474 67839 90520060
Initial insomnia 22.20 12.22 24 40524 9286 90578613
Affective disorder 22.02 12.22 22 40526 7771 90580128
Red blood cell sedimentation rate increased 21.97 12.22 5 40543 82590 90505309
Wheezing 21.94 12.22 46 40502 238034 90349865
Tachyphrenia 21.83 12.22 12 40536 1694 90586205
Blood bicarbonate abnormal 21.78 12.22 5 40543 48 90587851
Liver disorder 21.31 12.22 14 40534 121255 90466644
Diabetic neuropathy 21.04 12.22 17 40531 4557 90583342
Autonomic nervous system imbalance 20.66 12.22 15 40533 3435 90584464
Euphoric mood 20.54 12.22 18 40530 5391 90582508
Wound infection 20.51 12.22 11 40537 106391 90481508
Antidepressant discontinuation syndrome 20.39 12.22 6 40542 161 90587738
Treatment noncompliance 20.32 12.22 60 40488 51667 90536232
Crying 20.20 12.22 39 40509 25606 90562293
Complication of device removal 20.19 12.22 19 40529 6236 90581663
Mydriasis 20.14 12.22 29 40519 14983 90572916
Device breakage 20.13 12.22 28 40520 14016 90573883
Abnormal uterine bleeding 19.98 12.22 12 40536 2000 90585899
Rhabdomyolysis 19.70 12.22 59 40489 51197 90536702
Mental status changes 19.67 12.22 54 40494 44625 90543274
Interstitial lung disease 19.58 12.22 5 40543 76400 90511499
Syndactyly 19.49 12.22 8 40540 587 90587312
Headache 19.41 12.22 514 40034 862232 89725667
Therapeutic response unexpected 19.39 12.22 35 40513 21845 90566054
Exposure via ingestion 19.24 12.22 13 40535 2654 90585245
Therapy cessation 19.14 12.22 47 40501 36314 90551585
Flat affect 19.08 12.22 11 40537 1700 90586199
Oedema 19.05 12.22 38 40510 200257 90387642
Parkinsonism 18.62 12.22 27 40521 14038 90573861
Mania 18.54 12.22 27 40521 14097 90573802
Ovarian granulosa cell tumour 18.42 12.22 4 40544 29 90587870
Lung disorder 18.42 12.22 24 40524 149859 90438040
Nephrolithiasis 18.40 12.22 56 40492 49029 90538870
Nightmare 18.30 12.22 34 40514 21691 90566208
Psychotic disorder 18.21 12.22 42 40506 31188 90556711
Epilepsy 18.18 12.22 7 40541 82199 90505700
Exposure during pregnancy 18.07 12.22 51 40497 238359 90349540
Skin discomfort 17.90 12.22 11 40537 1910 90585989
Malignant neoplasm progression 17.90 12.22 13 40535 106857 90481042
Exposure via skin contact 17.88 12.22 23 40525 10682 90577217
Emotional distress 17.85 12.22 46 40502 36616 90551283
Myofascial pain syndrome 17.84 12.22 13 40535 2994 90584905
Cardiogenic shock 17.81 12.22 36 40512 24432 90563467
Depressed level of consciousness 17.71 12.22 72 40476 72712 90515187
Injection site swelling 17.70 12.22 63 40485 59776 90528123
Dystonia 17.65 12.22 29 40519 16790 90571109
Cleft lip and palate 17.65 12.22 8 40540 748 90587151
Impaired gastric emptying 17.56 12.22 25 40523 12784 90575115
Delusion 17.50 12.22 26 40522 13814 90574085
Gait inability 17.44 12.22 24 40524 146432 90441467
Hepatitis 17.43 12.22 5 40543 70734 90517165
Abdominal discomfort 17.18 12.22 134 40414 477194 90110705
Dental restoration failure 17.17 12.22 9 40539 1155 90586744
Sedation 17.17 12.22 54 40494 48117 90539782
Akathisia 17.13 12.22 23 40525 11136 90576763
Bradykinesia 17.07 12.22 18 40530 6770 90581129
Live birth 17.06 12.22 7 40541 79100 90508799
Therapeutic response shortened 17.06 12.22 34 40514 22845 90565054
Haemoglobin decreased 16.93 12.22 29 40519 161927 90425972
Dyskinesia 16.93 12.22 45 40503 36489 90551410
Cardiac arrest 16.87 12.22 92 40456 104843 90483056
Anhedonia 16.70 12.22 23 40525 11408 90576491
Perinatal depression 16.67 12.22 8 40540 851 90587048
Injury 16.65 12.22 40 40508 197309 90390590
Laryngeal granuloma 16.53 12.22 3 40545 7 90587892
Type 2 diabetes mellitus 16.52 12.22 42 40506 203202 90384697
Accidental exposure to product 16.50 12.22 49 40499 42317 90545582
Agoraphobia 16.47 12.22 7 40541 561 90587338
Dyspareunia 16.42 12.22 12 40536 2774 90585125
Mucosal inflammation 16.34 12.22 3 40545 57622 90530277
Cerebellar infarction 16.28 12.22 11 40537 2247 90585652
Autoimmune disorder 16.21 12.22 7 40541 76737 90511162
Acute respiratory failure 16.12 12.22 49 40499 42869 90545030
Needle issue 15.96 12.22 25 40523 13909 90573990
Insurance issue 15.93 12.22 22 40526 10936 90576963
Mood altered 15.93 12.22 28 40520 17116 90570783
Asthma 15.89 12.22 172 40376 241988 90345911
Impulse-control disorder 15.66 12.22 8 40540 974 90586925
Prescribed underdose 15.60 12.22 7 40541 75012 90512887
Restlessness 15.55 12.22 43 40505 35677 90552222
Sleep-related eating disorder 15.49 12.22 8 40540 996 90586903
Blepharospasm 15.48 12.22 3 40545 55442 90532457
Vitamin D deficiency 15.45 12.22 28 40520 17528 90570371
Hypertensive urgency 15.20 12.22 7 40541 679 90587220
Hallucination 15.07 12.22 64 40484 65895 90522004
Renal impairment 15.00 12.22 15 40533 105406 90482493
Drug effect less than expected 14.95 12.22 16 40532 6122 90581777
Prescribed overdose 14.94 12.22 13 40535 97612 90490287
Nail disorder 14.88 12.22 4 40544 59063 90528836
Hypersomnia 14.87 12.22 31 40517 21500 90566399
Narcolepsy 14.86 12.22 9 40539 1523 90586376
Blood pressure orthostatic 14.85 12.22 4 40544 77 90587822
Vertigo 14.63 12.22 66 40482 69745 90518154
Medication error 14.57 12.22 10 40538 84642 90503257
Sensation of foreign body 14.47 12.22 16 40532 6350 90581549
Psychomotor retardation 14.42 12.22 14 40534 4775 90583124
Psoriasis 14.26 12.22 114 40434 147640 90440259
Lethargy 14.22 12.22 61 40487 63078 90524821
Reversible cerebral vasoconstriction syndrome 14.21 12.22 13 40535 4117 90583782
Spinal operation 14.13 12.22 20 40528 10176 90577723
Attention deficit hyperactivity disorder 14.07 12.22 13 40535 4171 90583728
Osteoarthritis 14.01 12.22 43 40505 195687 90392212
Hypervigilance 13.98 12.22 6 40542 492 90587407
Restless legs syndrome 13.97 12.22 31 40517 22439 90565460
Embedded device 13.90 12.22 13 40535 4235 90583664
Flushing 13.83 12.22 77 40471 88414 90499485
Abnormal behaviour 13.82 12.22 31 40517 22597 90565302
Muscle necrosis 13.82 12.22 7 40541 837 90587062
Sciatica 13.77 12.22 15 40533 101367 90486532
Pleural effusion 13.69 12.22 18 40530 111973 90475926
Dermatillomania 13.68 12.22 5 40543 268 90587631
Product use issue 13.62 12.22 89 40459 329830 90258069
Snoring 13.62 12.22 14 40534 5112 90582787
Hyperkalaemia 13.61 12.22 6 40542 64958 90522941
Muscle twitching 13.51 12.22 32 40516 24170 90563729
Tension 13.48 12.22 12 40536 3670 90584229
Hospice care 13.39 12.22 19 40529 9685 90578214
Infection 13.33 12.22 101 40447 361993 90225906
Musculoskeletal stiffness 13.28 12.22 78 40470 296454 90291445
Alcohol withdrawal syndrome 13.22 12.22 7 40541 917 90586982
Cardiac death 13.03 12.22 6 40542 582 90587317
Disease progression 13.01 12.22 32 40516 156583 90431316
Injection site reaction 13.00 12.22 78 40470 92002 90495897
Hepatic cirrhosis 13 12.22 6 40542 63247 90524652
Abdominal pain 12.91 12.22 114 40434 395607 90192292
Muscle rigidity 12.82 12.22 23 40525 14286 90573613
Sleep deficit 12.73 12.22 7 40541 989 90586910
Stress cardiomyopathy 12.65 12.22 22 40526 13333 90574566
Product preparation error 12.58 12.22 19 40529 10242 90577657
Presbyopia 12.54 12.22 6 40542 634 90587265
Long QT syndrome 12.53 12.22 12 40536 4025 90583874
Accidental death 12.48 12.22 9 40539 2039 90585860
Urinary tract infection 12.46 12.22 199 40349 305433 90282466
Balance disorder 12.31 12.22 80 40468 97000 90490899
Injection site induration 12.29 12.22 19 40529 10449 90577450
Chills 12.28 12.22 101 40447 131880 90456019
Vision blurred 12.27 12.22 88 40460 110205 90477694
Thunderclap headache 12.23 12.22 5 40543 363 90587536

FDA Adverse Event Reporting System (Male)

MedDRA adverse event termLikelihood ratioLikelihood ratio thresholdPatients taking drug having adverse eventPatients taking drug not having adverse eventPatients not taking drug having adverse eventPatients not taking drug not having adverse event
Serotonin syndrome 224.29 15.67 125 13391 25720 42582099
Completed suicide 203.41 15.67 198 13318 96267 42511552
Sedation 162.70 15.67 108 13408 30367 42577452
Suicidal ideation 120.81 15.67 109 13407 48052 42559767
Dissociation 108.44 15.67 42 13474 3756 42604063
Anxiety 105.53 15.67 157 13359 118403 42489416
Irritability 91.65 15.67 74 13442 28054 42579765
Tardive dyskinesia 87.17 15.67 43 13473 6881 42600938
Agitation 74.88 15.67 97 13419 64217 42543602
Depression 61.14 15.67 119 13397 111244 42496575
Aggression 58.38 15.67 71 13445 44092 42563727
Product administration interrupted 51.33 15.67 27 13489 4939 42602880
Tremor 50.07 15.67 101 13415 96828 42510991
Drug abuse 42.48 15.67 99 13417 104672 42503147
Product dose omission issue 41.35 15.67 125 13391 154240 42453579
Obesity 40.72 15.67 37 13479 16422 42591397
Insomnia 38.73 15.67 103 13413 118150 42489669
Neuroleptic malignant syndrome 37.67 15.67 40 13476 21432 42586387
Toxicity to various agents 34.58 15.67 154 13362 228982 42378837
Withdrawal syndrome 32.29 15.67 31 13485 14744 42593075
General physical health deterioration 31.73 15.67 5 13511 151241 42456578
Febrile neutropenia 31.25 15.67 10 13506 185693 42422126
Electrocardiogram QRS complex prolonged 29.51 15.67 20 13496 5803 42602016
Akathisia 28.85 15.67 25 13491 10426 42597393
Suspected suicide 28.37 15.67 20 13496 6179 42601640
Muscle necrosis 27.86 15.67 11 13505 1034 42606785
Orthostatic hypotension 26.42 15.67 40 13476 30530 42577289
Seizure 26.25 15.67 91 13425 120470 42487349
Anger 25.99 15.67 26 13490 12992 42594827
Thrombocytopenia 25.97 15.67 14 13502 190265 42417554
Drug withdrawal syndrome 25.82 15.67 33 13483 21516 42586303
Poisoning deliberate 25.49 15.67 23 13493 10111 42597708
Wrong patient 25.35 15.67 9 13507 630 42607189
Post-traumatic stress disorder 25.26 15.67 13 13503 2272 42605547
Orthostatic tremor 24.56 15.67 4 13512 6 42607813
Behaviour disorder 23.90 15.67 19 13497 7035 42600784
Panic attack 23.80 15.67 23 13493 11022 42596797
Bipolar disorder 23.60 15.67 15 13501 3907 42603912
Pneumonia 23.57 15.67 63 13453 422086 42185733
Intentional overdose 23.48 15.67 51 13465 51405 42556414
Hypoparathyroidism 20.63 15.67 8 13508 717 42607102
Therapy interrupted 20.50 15.67 30 13486 22220 42585599
Anaemia 20.45 15.67 36 13480 280242 42327577
Pancytopenia 20.41 15.67 6 13510 117737 42490082
Acute kidney injury 20.35 15.67 55 13461 367282 42240537
Injection site reaction 20.31 15.67 25 13491 15696 42592123
Dermatitis atopic 19.82 15.67 22 13494 12382 42595437
Feeling abnormal 19.10 15.67 57 13459 69729 42538090
Lens dislocation 18.67 15.67 5 13511 135 42607684
Neonatal respiratory distress 18.42 15.67 8 13508 957 42606862
Renal impairment 18.41 15.67 6 13510 110222 42497597
Hypotonia neonatal 18.03 15.67 9 13507 1475 42606344
Stress cardiomyopathy 17.63 15.67 11 13505 2774 42605045
Parkinsonism 17.25 15.67 19 13497 10604 42597215
Alcoholism 17.12 15.67 11 13505 2919 42604900
Neutropenia 17.04 15.67 23 13493 199408 42408411
Coma 16.85 15.67 46 13470 53508 42554311
Nightmare 16.54 15.67 29 13487 24983 42582836
Disinhibition 16.52 15.67 12 13504 3883 42603936
Microvascular coronary artery disease 16.12 15.67 4 13512 79 42607740
Drug interaction 15.70 15.67 141 13375 266858 42340961

FDA Adverse Event Reporting System (Geriatric)

MedDRA adverse event termLikelihood ratioLikelihood ratio thresholdPatients taking drug having adverse eventPatients taking drug not having adverse eventPatients not taking drug having adverse eventPatients not taking drug not having adverse event
Completed suicide 1032.75 12.23 808 41930 241573 110304988
Serotonin syndrome 551.00 12.23 321 42417 58832 110487729
Suicidal ideation 261.53 12.23 246 42492 93691 110452870
Toxicity to various agents 178.10 12.23 496 42242 480059 110066502
Anxiety 160.49 12.23 388 42350 344690 110201871
Dissociation 140.66 12.23 71 42667 9771 110536790
Depression 126.84 12.23 337 42401 316998 110229563
Product dose omission issue 121.86 12.23 335 42403 321447 110225114
Suspected suicide 119.41 12.23 74 42664 15125 110531436
Dermatitis atopic 118.87 12.23 90 42648 25451 110521110
Agitation 110.35 12.23 174 42564 112877 110433684
Sedation 106.48 12.23 133 42605 69550 110477011
Intentional overdose 105.34 12.23 186 42552 132315 110414246
Product administration interrupted 101.66 12.23 60 42678 11232 110535329
Tremor 99.96 12.23 233 42505 201999 110344562
Withdrawal syndrome 98.60 12.23 88 42650 31292 110515269
General physical health deterioration 94.41 12.23 24 42714 425271 110121290
Injection site pain 86.83 12.23 204 42534 177718 110368843
Irritability 75.84 12.23 93 42645 47716 110498845
Tardive dyskinesia 72.53 12.23 52 42686 13527 110533034
Synovitis 72.43 12.23 10 42728 274082 110272479
Neuroleptic malignant syndrome 72.23 12.23 77 42661 33982 110512579
Febrile neutropenia 70.04 12.23 18 42720 316749 110229812
Hand deformity 68.32 12.23 4 42734 218502 110328059
Glossodynia 66.66 12.23 5 42733 221999 110324562
Drug abuse 62.45 12.23 180 42558 177231 110369330
Panic attack 62.38 12.23 66 42672 28874 110517687
Drug withdrawal syndrome 61.94 12.23 75 42663 37979 110508582
Infusion related reaction 60.73 12.23 36 42702 381126 110165435
Thrombocytopenia 59.87 12.23 30 42708 348855 110197706
Lower respiratory tract infection 59.44 12.23 11 42727 243095 110303466
Drug intolerance 58.54 12.23 43 42695 406469 110140092
Wound 56.48 12.23 11 42727 234426 110312135
Overdose 55.12 12.23 207 42531 233587 110312974
Anaemia 54.86 12.23 79 42659 547007 109999554
Impaired healing 54.84 12.23 6 42732 196711 110349850
Complication of device insertion 54.59 12.23 37 42701 8801 110537760
Suicide attempt 53.10 12.23 121 42617 103273 110443288
Insomnia 52.19 12.23 276 42462 360314 110186247
Systemic lupus erythematosus 51.54 12.23 17 42721 254321 110292240
Bezoar 51.44 12.23 27 42711 4027 110542534
Contraindicated product administered 51.36 12.23 16 42722 248251 110298310
Arthropathy 50.42 12.23 24 42714 287498 110259063
Pancytopenia 50.15 12.23 10 42728 209603 110336958
Helicobacter infection 49.57 12.23 6 42732 181871 110364690
Depressed mood 49.12 12.23 86 42652 60723 110485838
Corneal reflex decreased 48.98 12.23 15 42723 538 110546023
Neutropenia 48.49 12.23 44 42694 374576 110171985
Akathisia 47.92 12.23 45 42693 17068 110529493
Treatment failure 47.31 12.23 24 42714 277210 110269351
Cardio-respiratory arrest 47.18 12.23 124 42614 115712 110430849
Feeling abnormal 45.95 12.23 164 42574 180547 110366014
Hepatic enzyme increased 44.83 12.23 35 42703 320857 110225704
Folliculitis 44.56 12.23 6 42732 167647 110378914
Respiratory arrest 43.94 12.23 80 42658 58219 110488342
C-reactive protein increased 43.39 12.23 15 42723 217904 110328657
Pupillary reflex impaired 43.29 12.23 24 42714 3991 110542570
Muscle injury 42.75 12.23 3 42735 140804 110405757
Surgery 42.29 12.23 65 42673 41218 110505343
Muscle necrosis 41.29 12.23 18 42720 1779 110544782
Endocarditis enterococcal 41.08 12.23 12 42726 365 110546196
Anger 40.35 12.23 43 42695 18964 110527597
Stomatitis 39.65 12.23 28 42710 270214 110276347
Alcoholism 39.53 12.23 22 42716 3685 110542876
Injection site mass 39.23 12.23 48 42690 24565 110521996
Renal impairment 37.47 12.23 13 42725 188432 110358129
Pyrexia 37.11 12.23 200 42538 898065 109648496
Swelling 36.85 12.23 49 42689 350992 110195569
Generalised anxiety disorder 36.67 12.23 19 42719 2760 110543801
Liver injury 36.34 12.23 7 42731 150406 110396155
Behaviour disorder 36.30 12.23 30 42708 9617 110536944
Impaired quality of life 36.14 12.23 51 42687 29966 110516595
Seizure 35.96 12.23 175 42563 221010 110325551
Drug screen false positive 35.70 12.23 15 42723 1354 110545207
Inflammation 35.64 12.23 15 42723 193223 110353338
Mental disorder 35.49 12.23 58 42680 38733 110507828
Drug-induced liver injury 35.21 12.23 3 42735 120064 110426497
Mitral valve replacement 35.09 12.23 12 42726 614 110545947
Emotional disorder 35.08 12.23 37 42701 16123 110530438
Mental status changes 34.64 12.23 85 42653 76037 110470524
Disturbance in attention 34.58 12.23 75 42663 61920 110484641
Respiratory syncytial virus test positive 34.44 12.23 15 42723 1479 110545082
Poisoning 34.38 12.23 49 42689 29056 110517505
Joint swelling 34.37 12.23 75 42663 442770 110103791
Delusion 34.15 12.23 44 42694 23711 110522850
Electrocardiogram QRS complex prolonged 34.10 12.23 33 42705 12988 110533573
Blister 34.09 12.23 23 42715 227353 110319208
Major depression 31.81 12.23 29 42709 10592 110535969
Parkinsonism 31.74 12.23 41 42697 22146 110524415
Bursitis 31.48 12.23 6 42732 129912 110416649
Fall 31.46 12.23 364 42374 603118 109943443
Drug interaction 30.84 12.23 312 42426 499871 110046690
Anoxia 30.83 12.23 10 42728 434 110546127
Total cholesterol/HDL ratio abnormal 30.57 12.23 7 42731 78 110546483
Somnolence 30.40 12.23 208 42530 297241 110249320
Intentional self-injury 30.31 12.23 53 42685 37376 110509185
Mydriasis 30.23 12.23 40 42698 22117 110524444
Foreign body in reproductive tract 29.92 12.23 12 42726 962 110545599
Bipolar disorder 29.77 12.23 26 42712 8981 110537580
Hyperhidrosis 29.59 12.23 147 42591 187151 110359410
Hyperkalaemia 29.46 12.23 8 42730 135788 110410773
Aggression 28.97 12.23 68 42670 59142 110487419
Extrapyramidal disorder 28.93 12.23 45 42693 28822 110517739
Stress cardiomyopathy 28.78 12.23 33 42705 15773 110530788
Post-traumatic stress disorder 27.97 12.23 22 42716 6574 110539987
Hypertensive urgency 27.93 12.23 12 42726 1145 110545416
Sleep disorder due to general medical condition, insomnia type 27.55 12.23 4 42734 105639 110440922
Areflexia 27.47 12.23 22 42716 6747 110539814
COVID-19 27.23 12.23 175 42563 244885 110301676
Interstitial lung disease 27.03 12.23 10 42728 139324 110407237
Stiff person syndrome 26.95 12.23 10 42728 650 110545911
Product dose omission in error 26.91 12.23 39 42699 23473 110523088
Device expulsion 26.66 12.23 45 42693 30846 110515715
Somnambulism 26.38 12.23 21 42717 6384 110540177
Muscle twitching 26.36 12.23 44 42694 29891 110516670
Hallucination, auditory 26.25 12.23 41 42697 26356 110520205
Pre-existing condition improved 26.04 12.23 21 42717 6505 110540056
Rheumatoid arthritis 25.58 12.23 48 42690 299565 110246996
Nightmare 25.17 12.23 50 42688 38813 110507748
Dry skin 25.08 12.23 95 42643 107558 110439003
Panic disorder 25.05 12.23 16 42722 3445 110543116
Initial insomnia 24.74 12.23 25 42713 10364 110536197
Ovarian granulosa cell tumour 24.72 12.23 5 42733 29 110546532
Ill-defined disorder 24.69 12.23 15 42723 156838 110389723
Nausea 24.67 12.23 638 42100 1235052 109311509
Malignant neoplasm progression 24.42 12.23 19 42719 174548 110372013
Musculoskeletal pain 24.26 12.23 21 42717 183002 110363559
Mucosal inflammation 24.25 12.23 4 42734 96137 110450424
Therapy interrupted 24.14 12.23 57 42681 49765 110496796
Disinhibition 23.96 12.23 15 42723 3119 110543442
Plasma cell mastitis 23.91 12.23 5 42733 35 110546526
Illness 23.88 12.23 78 42660 82093 110464468
Device breakage 23.82 12.23 28 42710 13741 110532820
Product preparation error 23.78 12.23 25 42713 10854 110535707
Attention deficit hyperactivity disorder 23.53 12.23 17 42721 4474 110542087
Liver disorder 23.25 12.23 13 42725 142230 110404331
Vision blurred 23.09 12.23 105 42633 128917 110417644
Mobility decreased 23.06 12.23 35 42703 237387 110309174
Pleural effusion 22.82 12.23 21 42717 177688 110368873
Treatment noncompliance 22.77 12.23 71 42667 72919 110473642
Needle issue 22.50 12.23 31 42707 17809 110528752
Peripheral venous disease 22.37 12.23 3 42735 84114 110462447
Fatigue 22.03 12.23 620 42118 1215338 109331223
Injection site reaction 21.91 12.23 80 42658 88990 110457571
Disease progression 21.80 12.23 38 42700 243996 110302565
Flat affect 21.74 12.23 13 42725 2492 110544069
Antidepressant discontinuation syndrome 21.63 12.23 6 42732 151 110546410
Therapy cessation 21.38 12.23 51 42687 44806 110501755
Feeling of despair 21.34 12.23 15 42723 3783 110542778
Psychotic disorder 21.21 12.23 55 42683 50882 110495679
Aortic valve replacement 21.12 12.23 11 42727 1615 110544946
Dermatillomania 20.98 12.23 7 42731 332 110546229
Complication of device removal 20.88 12.23 16 42722 4604 110541957
Social avoidant behaviour 20.83 12.23 17 42721 5352 110541209
Rhabdomyolysis 20.82 12.23 97 42641 120304 110426257
Secondary hypertension 20.52 12.23 8 42730 595 110545966
Hypercholesterolaemia 20.37 12.23 5 42733 90832 110455729
Joint range of motion decreased 20.10 12.23 11 42727 121821 110424740
Tachyphrenia 19.86 12.23 12 42726 2344 110544217
Hospitalisation 19.85 12.23 108 42630 142385 110404176
Hypothermia 19.70 12.23 36 42702 26266 110520295
Restlessness 19.69 12.23 57 42681 56202 110490359
False positive investigation result 19.62 12.23 10 42728 1404 110545157
Therapeutic response unexpected 19.61 12.23 34 42704 23809 110522752
Hallucination, tactile 19.59 12.23 9 42729 1006 110545555
Orthostatic tremor 19.52 12.23 4 42734 25 110546536
Hypersensitivity 19.51 12.23 85 42653 403913 110142648
Headache 19.47 12.23 462 42276 881915 109664646
Injection site induration 19.45 12.23 23 42715 11360 110535201
Oedema 19.40 12.23 32 42706 209944 110336617
Haemoglobin decreased 19.38 12.23 42 42696 248685 110297876
Hallucination 19.24 12.23 84 42654 101348 110445213
Mania 18.89 12.23 31 42707 20765 110525796
Euphoric mood 18.79 12.23 20 42718 8807 110537754
Therapeutic product effect decreased 18.43 12.23 42 42696 244274 110302287
Wheezing 18.36 12.23 45 42693 255185 110291376
Intentional dose omission 18.33 12.23 30 42708 20050 110526511
Cardiogenic shock 18.09 12.23 56 42682 57282 110489279
Impulse-control disorder 18.04 12.23 11 42727 2183 110544378
Hepatic function abnormal 18.02 12.23 6 42732 89289 110457272
Accidental exposure to product 17.83 12.23 51 42687 49957 110496604
Anticholinergic syndrome 17.56 12.23 14 42724 4266 110542295
Sleep disorder due to a general medical condition 17.48 12.23 52 42686 52060 110494501
Neurodermatitis 17.45 12.23 12 42726 2920 110543641
Ascites 17.44 12.23 7 42731 92801 110453760
Sleep deficit 17.39 12.23 10 42728 1782 110544779
Platelet count decreased 17.07 12.23 40 42698 230403 110316158
Blood bicarbonate abnormal 17.06 12.23 5 42733 154 110546407
Laryngeal granuloma 16.97 12.23 3 42735 7 110546554
Diabetic neuropathy 16.96 12.23 17 42721 6982 110539579
Grip strength decreased 16.87 12.23 5 42733 80169 110466392
Hypersomnia 16.86 12.23 35 42703 28026 110518535
Stress 16.86 12.23 83 42655 105265 110441296
Mood swings 16.80 12.23 31 42707 22781 110523780
Impaired gastric emptying 16.64 12.23 23 42715 13252 110533309
Crying 16.63 12.23 33 42705 25595 110520966
Epilepsy 16.60 12.23 9 42729 100200 110446361
Hepatitis 16.59 12.23 7 42731 90047 110456514
Accidental exposure to product by child 16.52 12.23 12 42726 3186 110543375
Septic shock 16.50 12.23 22 42716 157506 110389055
Injection site swelling 16.49 12.23 57 42681 61733 110484828
Myofascial pain syndrome 16.44 12.23 11 42727 2562 110543999
Gastrointestinal disorder 16.37 12.23 44 42694 241908 110304653
Alopecia 16.26 12.23 79 42659 364674 110181887
Depressed level of consciousness 16.25 12.23 86 42652 112192 110434369
Emotional distress 16.24 12.23 46 42692 44801 110501760
Hospice care 16.22 12.23 22 42716 12451 110534110
Lens dislocation 16.15 12.23 5 42733 186 110546375
Irritable bowel syndrome 16.14 12.23 24 42714 164191 110382370
Embedded device 16.14 12.23 13 42725 4020 110542541
Ideas of reference 16.03 12.23 5 42733 191 110546370
Poisoning deliberate 16.01 12.23 33 42705 26298 110520263
Exposure via ingestion 15.90 12.23 14 42724 4886 110541675
Agoraphobia 15.89 12.23 7 42731 709 110545852
Skin discomfort 15.88 12.23 10 42728 2100 110544461
Dizziness 15.82 12.23 367 42371 697826 109848735
Presbyopia 15.68 12.23 7 42731 732 110545829
Therapeutic response shortened 15.60 12.23 35 42703 29548 110517013
Live birth 15.24 12.23 4 42734 69480 110477081
Lung disorder 15.22 12.23 29 42709 180018 110366543
Migraine 15.19 12.23 116 42622 171536 110375025
Affective disorder 14.89 12.23 20 42718 11221 110535340
Coma 14.87 12.23 87 42651 117782 110428779
Pneumonia 14.82 12.23 244 42494 876470 109670091
Maternal exposure during pregnancy 14.63 12.23 50 42688 254833 110291728
Antisocial behaviour 14.60 12.23 7 42731 861 110545700
Increased appetite 14.53 12.23 23 42715 14954 110531607
Muscle rigidity 14.47 12.23 30 42708 24001 110522560
Death 14.22 12.23 362 42376 698507 109848054
Generalised tonic-clonic seizure 14.20 12.23 50 42688 54630 110491931
Dystonia 14.14 12.23 31 42707 25774 110520787
Drug dependence 14.10 12.23 47 42691 49973 110496588
Abnormal behaviour 14.10 12.23 40 42698 38999 110507562
Respiratory disorder 14.05 12.23 5 42733 71377 110475184
Device dislocation 14.00 12.23 35 42703 31669 110514892
Restless legs syndrome 13.97 12.23 30 42708 24596 110521965
Clonus 13.89 12.23 17 42721 8699 110537862
Exposure via skin contact 13.88 12.23 21 42717 13126 110533435
Injection site abscess 13.84 12.23 9 42729 1997 110544564
Tension 13.54 12.23 13 42725 5065 110541496
Ankle fracture 13.44 12.23 26 42712 19793 110526768
Hypoparathyroidism 13.43 12.23 8 42730 1522 110545039
Dopamine transporter scintigraphy abnormal 13.40 12.23 3 42735 30 110546531
Pupillary deformity 13.40 12.23 3 42735 30 110546531
Nail disorder 13.36 12.23 3 42735 57932 110488629
Gait inability 13.34 12.23 20 42718 136356 110410205
Bone marrow failure 13.34 12.23 3 42735 57845 110488716
Dyskinesia 13.33 12.23 47 42691 51399 110495162
Hyperphagia 13.32 12.23 11 42727 3520 110543041
Hepatotoxicity 13.26 12.23 4 42734 63396 110483165
Hypervigilance 13.23 12.23 6 42732 651 110545910
Melaena 13.23 12.23 5 42733 68752 110477809
Liver function test increased 13.21 12.23 9 42729 88539 110458022
Psoriasis 13.18 12.23 96 42642 139897 110406664
Multiple sclerosis 13.10 12.23 30 42708 25668 110520893
Liquid product physical issue 13.10 12.23 8 42730 1592 110544969
Red blood cell sedimentation rate increased 13.02 12.23 7 42731 78295 110468266
Obsessive-compulsive disorder 12.99 12.23 15 42723 7226 110539335
Gestational hypertension 12.96 12.23 9 42729 2225 110544336
Dyspareunia 12.91 12.23 9 42729 2240 110544321
Expired product administered 12.89 12.23 16 42722 8304 110538257
Hepatic cirrhosis 12.87 12.23 5 42733 67621 110478940
Wound infection 12.86 12.23 11 42727 96454 110450107
Activation syndrome 12.79 12.23 5 42733 375 110546186
Dental restoration failure 12.76 12.23 7 42731 1140 110545421
Gynaecomastia 12.74 12.23 17 42721 9473 110537088
Agranulocytosis 12.73 12.23 4 42734 61756 110484805
Anhedonia 12.69 12.23 22 42716 15406 110531155
Radioisotope scan abnormal 12.57 12.23 6 42732 731 110545830
Blepharospasm 12.34 12.23 3 42735 54848 110491713
Spinal operation 12.27 12.23 18 42720 10954 110535607

FDA Adverse Event Reporting System (Pediatric)

None

Pharmacologic Action:

SourceCodeDescription
ATC N05BE01 NERVOUS SYSTEM
PSYCHOLEPTICS
ANXIOLYTICS
Azaspirodecanedione derivatives
CHEBI has role CHEBI:35469 antidepressant
CHEBI has role CHEBI:35474 anxiolytic drug
CHEBI has role CHEBI:35476 antipsychotic agent
CHEBI has role CHEBI:35717 sedative
CHEBI has role CHEBI:35941 serotonergic agonist
CHEBI has role CHEBI:48407 antiparkinson drug
CHEBI has role CHEBI:55324 gastrointestinal drug
CHEBI has role CHEBI:76779 EC 3.4.21.26 (prolyl oligopeptidase) inhibitor
MeSH PA D002492 Central Nervous System Depressants
MeSH PA D011619 Psychotropic Drugs
MeSH PA D014151 Anti-Anxiety Agents
MeSH PA D017366 Serotonin Receptor Agonists
MeSH PA D018377 Neurotransmitter Agents
MeSH PA D018490 Serotonin Agents

Drug Use | Suggest Off label Use Form| |View source of the data|

DiseaseRelationSNOMED_IDDOID
Generalized anxiety disorder indication 21897009 DOID:14320
Acute nephropathy contraindication 58574008
Hepatic failure contraindication 59927004




🐶 Veterinary Drug Use

None

🐶 Veterinary products

None

Acid dissociation constants calculated using MoKa v3.0.0

Dissociation levelDissociation constantType (acidic/basic)
pKa1 7.51 Basic
pKa2 2.23 Basic

Orange Book patent data (new drug applications)

None

Orange Book exclusivity data (new drug applications)

None

Bioactivity Summary:

TargetClassPharosUniProtActionTypeActivity value
(-log[M])		Mechanism
action		Bioact sourceMoA source
5-hydroxytryptamine receptor 1A GPCR PARTIAL AGONIST EC50 7.25 WOMBAT-PK CHEMBL
Sigma non-opioid intracellular receptor 1 Membrane receptor Ki 7.32 WOMBAT-PK
Potassium voltage-gated channel subfamily H member 2 Ion channel IC50 5.40 CHEMBL
Cytochrome P450 3A4 Enzyme Ki 5.13 WOMBAT-PK
5-hydroxytryptamine receptor 2A GPCR Ki 6.60 WOMBAT-PK
5-hydroxytryptamine receptor 2B GPCR Ki 6.41 WOMBAT-PK
5-hydroxytryptamine receptor 2C GPCR Ki 6.04 WOMBAT-PK
5-hydroxytryptamine receptor 7 GPCR Ki 6.08 CHEMBL
Alpha-1A adrenergic receptor GPCR Ki 6.44 WOMBAT-PK
D(3) dopamine receptor GPCR Ki 6.18 CHEMBL
D(4) dopamine receptor GPCR Ki 7 WOMBAT-PK
Alpha-1D adrenergic receptor GPCR Ki 6.28 DRUG MATRIX
Solute carrier family 22 member 2 Transporter IC50 4.92 CHEMBL
Multidrug and toxin extrusion protein 1 Transporter IC50 5.77 CHEMBL
Multidrug and toxin extrusion protein 2 Transporter IC50 4.34 CHEMBL
D(2) dopamine receptor GPCR Ki 7.68 WOMBAT-PK
5-hydroxytryptamine receptor 1B GPCR Ki 7.77 CHEMBL
Membrane-associated progesterone receptor component 1 Membrane receptor IC50 5.47 DRUG MATRIX
D(2) dopamine receptor GPCR Ki 6.92 CHEMBL
5-hydroxytryptamine receptor 1A GPCR Ki 8.42 CHEMBL
5-hydroxytryptamine receptor 2A GPCR Ki 6.32 CHEMBL
Sigma non-opioid intracellular receptor 1 Membrane receptor Ki 7.32 CHEMBL
5-hydroxytryptamine receptor 7 GPCR AGONIST Ki 6.40 IUPHAR
5-hydroxytryptamine receptor 7 GPCR ANTAGONIST Ki 6.40 IUPHAR
D(1A) dopamine receptor GPCR Ki 5.21 CHEMBL
D(2) dopamine receptor GPCR Ki 7.36 CHEMBL
5-hydroxytryptamine receptor 2C GPCR IC50 6 CHEMBL
Alpha-1A adrenergic receptor GPCR IC50 4.80 CHEMBL
Alpha-2A adrenergic receptor GPCR IC50 5 CHEMBL
5-hydroxytryptamine receptor 2A GPCR Ki 6.75 CHEMBL
Serotonin 1 (5-HT1) receptor GPCR IC50 7.02 CHEMBL
Adrenergic receptor alpha-2 GPCR IC50 5 CHEMBL
Dopamine receptor GPCR IC50 6.92 CHEMBL
Adrenergic receptor alpha-1 GPCR Ki 6.86 CHEMBL
Serotonin 2 (5-HT2) receptor GPCR Ki 6.76 CHEMBL

External reference:

IDSource
4019646 VUID
N0000147739 NUI
D00702 KEGG_DRUG
33386-08-2 SECONDARY_CAS_RN
1827 RXNORM
C0006462 UMLSCUI
CHEBI:3223 CHEBI
YLX PDB_CHEM_ID
CHEMBL49 ChEMBL_ID
CHEMBL1200399 ChEMBL_ID
DB00490 DRUGBANK_ID
D002065 MESH_DESCRIPTOR_UI
2477 PUBCHEM_CID
36 IUPHAR_LIGAND_ID
3456 INN_ID
TK65WKS8HL UNII
37673 MMSL
4308 MMSL
d00182 MMSL
387523009 SNOMEDCT_US
419484002 SNOMEDCT_US
91452003 SNOMEDCT_US
4018813 VANDF
4019646 VANDF
001468 NDDF
004586 NDDF
TK65WKS8HL INXIGHT DRUGS

Pharmaceutical products:

ProductCategoryIngredientsNDCFormQuantityRouteMarketingLabel
Buspirone Hydrochloride HUMAN PRESCRIPTION DRUG LABEL 1 0093-0053 TABLET 5 mg ORAL ANDA 28 sections
Buspirone Hydrochloride HUMAN PRESCRIPTION DRUG LABEL 1 0093-0054 TABLET 10 mg ORAL ANDA 28 sections
Buspirone Hydrochloride HUMAN PRESCRIPTION DRUG LABEL 1 0093-1003 TABLET 15 mg ORAL ANDA 28 sections
Buspirone Hydrochloride HUMAN PRESCRIPTION DRUG LABEL 1 0093-5200 TABLET 30 mg ORAL ANDA 28 sections
Buspirone Hydrochloride HUMAN PRESCRIPTION DRUG LABEL 1 0378-1140 TABLET 5 mg ORAL ANDA 27 sections
Buspirone Hydrochloride HUMAN PRESCRIPTION DRUG LABEL 1 0378-1150 TABLET 10 mg ORAL ANDA 27 sections
Buspirone Hydrochloride HUMAN PRESCRIPTION DRUG LABEL 1 0378-1165 TABLET 15 mg ORAL ANDA 27 sections
Buspirone Hydrochloride HUMAN PRESCRIPTION DRUG LABEL 1 0378-1175 TABLET 30 mg ORAL ANDA 27 sections
Buspirone Hydrochloride HUMAN PRESCRIPTION DRUG LABEL 1 0615-7689 TABLET 15 mg ORAL ANDA 28 sections
Buspirone Hydrochloride HUMAN PRESCRIPTION DRUG LABEL 1 0615-7714 TABLET 5 mg ORAL ANDA 28 sections
Buspirone Hydrochloride HUMAN PRESCRIPTION DRUG LABEL 1 0615-7718 TABLET 10 mg ORAL ANDA 28 sections
Buspirone Hydrochloride HUMAN PRESCRIPTION DRUG LABEL 1 0615-8434 TABLET 7.50 mg ORAL ANDA 22 sections
Buspirone Hydrochloride HUMAN PRESCRIPTION DRUG LABEL 1 0615-8527 TABLET 30 mg ORAL ANDA 28 sections
Buspirone hydrochloride HUMAN PRESCRIPTION DRUG LABEL 1 0904-6899 TABLET 15 mg ORAL ANDA 22 sections
Buspirone Hydrochloride HUMAN PRESCRIPTION DRUG LABEL 1 0904-7121 TABLET 10 mg ORAL ANDA 15 sections
Buspirone Hydrochloride HUMAN PRESCRIPTION DRUG LABEL 1 0904-7122 TABLET 5 mg ORAL ANDA 15 sections
Buspirone HCl HUMAN PRESCRIPTION DRUG LABEL 1 10544-176 TABLET 10 mg ORAL ANDA 27 sections
Buspirone hydrochloride HUMAN PRESCRIPTION DRUG LABEL 1 11788-057 TABLET 5 mg ORAL ANDA 15 sections
Buspirone hydrochloride HUMAN PRESCRIPTION DRUG LABEL 1 11788-058 TABLET 7.50 mg ORAL ANDA 15 sections
Buspirone hydrochloride HUMAN PRESCRIPTION DRUG LABEL 1 11788-059 TABLET 10 mg ORAL ANDA 15 sections
Buspirone hydrochloride HUMAN PRESCRIPTION DRUG LABEL 1 11788-060 TABLET 15 mg ORAL ANDA 15 sections
Buspirone hydrochloride HUMAN PRESCRIPTION DRUG LABEL 1 11788-061 TABLET 30 mg ORAL ANDA 15 sections
BUSPIRONE HYDROCHLORIDE HUMAN PRESCRIPTION DRUG LABEL 1 16590-375 TABLET 30 mg ORAL ANDA 27 sections
BUSPIRONE HCl HUMAN PRESCRIPTION DRUG LABEL 1 16590-579 TABLET 15 mg ORAL ANDA 27 sections
BUSPIRONE HUMAN PRESCRIPTION DRUG LABEL 1 16590-600 TABLET 10 mg ORAL ANDA 13 sections
BUSPIRONE HYDROCHLORIDE HUMAN PRESCRIPTION DRUG LABEL 1 16590-727 TABLET 7.50 mg ORAL ANDA 26 sections
Buspirone Hydrochloride HUMAN PRESCRIPTION DRUG LABEL 1 16729-200 TABLET 5 mg ORAL ANDA 29 sections
Buspirone Hydrochloride HUMAN PRESCRIPTION DRUG LABEL 1 16729-200 TABLET 5 mg ORAL ANDA 29 sections
Buspirone Hydrochloride HUMAN PRESCRIPTION DRUG LABEL 1 16729-201 TABLET 7.50 mg ORAL ANDA 29 sections
Buspirone Hydrochloride HUMAN PRESCRIPTION DRUG LABEL 1 16729-201 TABLET 7.50 mg ORAL ANDA 29 sections