chenodiol 🐶 Veterinary Use | Indications/Contra | FAERs-F | FAERs-M | Orange Bk | BioActivity |

Stem definitionDrug idCAS RN
4361 474-25-9

Description:

MoleculeDescription

Molfile Inchi Smiles

Synonyms:

  • chenodiol
  • chenodeoxycholic acid
  • chenic acid
  • anthropodesoxycholic acid
  • anthropododesoxycholic acid
  • chenodesoxycholic acid
  • gallodesoxycholic acid
A bile acid, usually conjugated with either glycine or taurine. It acts as a detergent to solubilize fats for intestinal absorption and is reabsorbed by the small intestine. It is used as cholagogue, a choleretic laxative, and to prevent or dissolve gallstones.
  • Molecular weight: 392.58
  • Formula: C24H40O4
  • CLOGP: 4.51
  • LIPINSKI: 0
  • HAC: 4
  • HDO: 3
  • TPSA: 77.76
  • ALOGS: -4.30
  • ROTB: 4
  • Status: OFP
    • Legend:
    OFP - off patent
    OFM - off market
    ONP - on patent

Drug dosage:

DoseUnitRoute
1 g O

ADMET properties:

PropertyValueReference
Vd (Volume of distribution) 0.19 L/kg Lombardo F, Berellini G, Obach RS
CL (Clearance) 5.70 mL/min/kg Lombardo F, Berellini G, Obach RS
t_half (Half-life) 1.42 hours Lombardo F, Berellini G, Obach RS

Approvals:

DateAgencyCompanyOrphan
July 28, 1983 FDA

FDA Adverse Event Reporting System (Female)

None

FDA Adverse Event Reporting System (Male)

None

FDA Adverse Event Reporting System (Geriatric)

None

FDA Adverse Event Reporting System (Pediatric)

None

Pharmacologic Action:

SourceCodeDescription
ATC A05AA01 ALIMENTARY TRACT AND METABOLISM
BILE AND LIVER THERAPY
BILE THERAPY
Bile acids and derivatives
MeSH PA D002400 Cathartics
MeSH PA D005765 Gastrointestinal Agents
CHEBI has role CHEBI:75771 Mus musculus metabolites
CHEBI has role CHEBI:77746 Homo sapiens metabolite

Drug Use | Suggest Off label Use Form| |View source of the data|

DiseaseRelationSNOMED_IDDOID
Calculus in biliary tract indication 266474003
Hypercholesterolemia contraindication 13644009
Obstruction of bile duct contraindication 30144000
Primary biliary cirrhosis contraindication 31712002 DOID:12236
Diarrhea contraindication 62315008
Liver function tests abnormal contraindication 166603001
Disease of liver contraindication 235856003 DOID:409
Sclerosing cholangitis contraindication 235917005 DOID:14268
Pregnancy, function contraindication 289908002
Gallstone Complications contraindication




🐶 Veterinary Drug Use

None

🐶 Veterinary products

None

Acid dissociation constants calculated using MoKa v3.0.0

Dissociation levelDissociation constantType (acidic/basic)
pKa1 4.92 acidic

Orange Book patent data (new drug applications)

None

Orange Book exclusivity data (new drug applications)

None

Bioactivity Summary:

TargetClassPharosUniProtActionTypeActivity value
(-log[M])		Mechanism
action		Bioact sourceMoA source
Bile acid receptor Nuclear hormone receptor AGONIST EC50 5.47 CHEMBL CHEMBL
fMet-Leu-Phe receptor GPCR ANTAGONIST Ki 4 IUPHAR
G-protein coupled bile acid receptor 1 GPCR AGONIST EC50 5.40 IUPHAR

External reference:

IDSource
0GEI24LG0J UNII
4022365 VUID
D00163 KEGG_DRUG
N0000146754 NUI
4018428 VANDF
4022365 VANDF
C0008024 UMLSCUI
CHEBI:16755 CHEBI
JN3 PDB_CHEM_ID
CHEMBL240597 ChEMBL_ID
10133 PUBCHEM_CID
DB06777 DRUGBANK_ID
4391 INN_ID
608 IUPHAR_LIGAND_ID
2323 RXNORM
25632 MMSL
d07268 MMSL
001208 NDDF
82490009 SNOMEDCT_US
89132005 SNOMEDCT_US
D002635 MESH_DESCRIPTOR_UI

Pharmaceutical products:

ProductCategoryIngredientsNDCFormQuantityRouteMarketingLabel
Chenodiol HUMAN PRESCRIPTION DRUG LABEL 1 0722-7121 TABLET, FILM COATED 250 mg ORAL ANDA 19 sections
Chenodal HUMAN PRESCRIPTION DRUG LABEL 1 45043-876 TABLET, FILM COATED 250 mg ORAL ANDA 18 sections
Chenodal HUMAN PRESCRIPTION DRUG LABEL 1 68974-876 TABLET, FILM COATED 250 mg ORAL ANDA 20 sections
Chenodal HUMAN PRESCRIPTION DRUG LABEL 1 68974-876 TABLET, FILM COATED 250 mg ORAL ANDA 20 sections
Chenodiol HUMAN PRESCRIPTION DRUG LABEL 1 79739-7121 TABLET, FILM COATED 250 mg ORAL ANDA 19 sections
Chenodiol HUMAN PRESCRIPTION DRUG LABEL 1 79739-7121 TABLET, FILM COATED 250 mg ORAL ANDA 19 sections