DrugCentral 2023 ๐
2022 Update-Veterinary Drugs & Uses
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DrugCentral 2023 ๐
2022 Update-Veterinary Drugs & Uses
Search
Structure ๐
Similarity ๐
Smart API
Redial
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L1000
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FDA-approved
EMA-approved
PMDA-approved
Target Card Uniprot Example:
P23975
buserelin ๐ถ
Veterinary Use |
Indications/Contra
| FAERs-F
| FAERs-M
| Orange Bk
| BioActivity |
Stem definition
Drug id
CAS RN
pituitary hormone-release stimulating peptides
436
57982-77-1
Description:
Molecule
Description
Molfile
Inchi
Smiles
Synonyms:
buserelin
etilamide
receptal
buserelin acetate
suprecur
A potent synthetic analog of GONADOTROPIN-RELEASING HORMONE with D-serine substitution at residue 6, glycine10 deletion, and other modifications.
Molecular weight: 1239.45
Formula: C60H86N16O13
CLOGP: -3.63
LIPINSKI: 3
HAC: 29
HDO: 16
TPSA: 438.27
ALOGS: -4.51
ROTB: 33
Drug dosage:
Dose
Unit
Route
0.11
mg
implant
1.20
mg
N
1.50
mg
P
ADMET properties:
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Property
Value
Reference
BDDCS (Biopharmaceutical Drug Disposition Classification System)
3
Bocci G, Oprea TI, Benet LZ
MRTD (Maximum Recommended Therapeutic Daily Dose)
0.02 ยตM/kg/day
Contrera JF, Matthews EJ, Kruhlak NL, Benz RD
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Approvals:
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Date
Agency
Company
Orphan
Feb. 25, 2022
PMDA
Sanofi K.K.
Jan. 1, 1984
YEAR INTRODUCED
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FDA Adverse Event Reporting System (Female)
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MedDRA adverse event term
Likelihood ratio
Likelihood ratio threshold
Patients taking drug having adverse event
Patients taking drug not having adverse event
Patients not taking drug having adverse event
Patients not taking drug not having adverse event
Ovarian hyperstimulation syndrome
104.13
51.45
15
77
3999
63484931
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FDA Adverse Event Reporting System (Male)
None
FDA Adverse Event Reporting System (Geriatric)
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MedDRA adverse event term
Likelihood ratio
Likelihood ratio threshold
Patients taking drug having adverse event
Patients taking drug not having adverse event
Patients not taking drug having adverse event
Patients not taking drug not having adverse event
Ovarian hyperstimulation syndrome
95.74
63.15
15
201
3556
79740616
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FDA Adverse Event Reporting System (Pediatric)
None
Pharmacologic Action:
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Source
Code
Description
ATC
L02AE01
ANTINEOPLASTIC AND IMMUNOMODULATING AGENTS
ENDOCRINE THERAPY
HORMONES AND RELATED AGENTS
Gonadotropin releasing hormone analogues
MeSH PA
D005300
Fertility Agents, Female
MeSH PA
D012102
Reproductive Control Agents
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Drug Use
| Suggest Off label Use Form|
|View source of the data|
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Disease
Relation
SNOMED_ID
DOID
Induction of final follicular maturation
indication
Prevention of premature ovulation
indication
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๐ถ Veterinary Drug Use
None
๐ถ Veterinary products
None
Acid dissociation constants calculated using MoKa v3.0.0
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Dissociation level
Dissociation constant
Type (acidic/basic)
pKa1
9.65
acidic
pKa2
11.9
acidic
pKa3
12.86
acidic
pKa4
13.14
acidic
pKa5
13.23
acidic
pKa6
13.59
acidic
pKa7
10.75
Basic
pKa8
6.69
Basic
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Orange Book patent data (new drug applications)
None
Orange Book exclusivity data (new drug applications)
None
Bioactivity Summary:
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Target
Class
Pharos
UniProt
Action
Type
Activity value
(-log[M])
Mechanism
action
Bioact source
MoA source
Gonadotropin-releasing hormone receptor
GPCR
P30968
GNRHR_HUMAN
AGONIST
EC50
10.52
IUPHAR
IUPHAR
Lutropin-choriogonadotropic hormone receptor
GPCR
P22888
LSHR_HUMAN
Kd
8.57
WOMBAT-PK
Gonadotropin-releasing hormone receptor
GPCR
GNRHR_MOUSE
AGONIST
EC50
10.05
IUPHAR
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External reference:
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ID
Source
003708
NDDF
003709
NDDF
008310
NDDF
008311
NDDF
1825
RXNORM
327301004
SNOMEDCT_US
3860
IUPHAR_LIGAND_ID
395744006
SNOMEDCT_US
4045
INN_ID
426572004
SNOMEDCT_US
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Pharmaceutical products:
None
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buserelin