Stem definition | Drug id | CAS RN |
---|---|---|
anorexics | 435 | 34911-55-2 |
Dose | Unit | Route |
---|---|---|
0.30 | g | O |
Property | Value | Reference |
---|---|---|
BDDCS (Biopharmaceutical Drug Disposition Classification System) | 1 | Benet LZ, Broccatelli F, Oprea TI |
S (Water solubility) | 312 mg/mL | Benet LZ, Broccatelli F, Oprea TI |
EoM (Fraction excreted unchanged in urine) | 0.50 % | Benet LZ, Broccatelli F, Oprea TI |
MRTD (Maximum Recommended Therapeutic Daily Dose) | 31.28 ยตM/kg/day | Contrera JF, Matthews EJ, Kruhlak NL, Benz RD |
Date | Agency | Company | Orphan |
---|---|---|---|
Dec. 30, 1985 | FDA | GLAXOSMITHKLINE |
MedDRA adverse event term | Likelihood ratio | Likelihood ratio threshold | Patients taking drug having adverse event | Patients taking drug not having adverse event | Patients not taking drug having adverse event | Patients not taking drug not having adverse event |
---|---|---|---|---|---|---|
Completed suicide | 3414.53 | 9.96 | 2728 | 134399 | 131105 | 56023835 |
Toxicity to various agents | 788.65 | 9.96 | 1708 | 135419 | 222856 | 55932084 |
Depression | 617.00 | 9.96 | 1357 | 135770 | 178760 | 55976180 |
Overdose | 472.00 | 9.96 | 890 | 136237 | 104940 | 56050000 |
Intentional overdose | 460.26 | 9.96 | 690 | 136437 | 67427 | 56087513 |
Anxiety | 417.76 | 9.96 | 1223 | 135904 | 191949 | 55962991 |
Generalised tonic-clonic seizure | 417.60 | 9.96 | 420 | 136707 | 27146 | 56127794 |
Seizure | 404.77 | 9.96 | 922 | 136205 | 124197 | 56030743 |
Suicidal ideation | 377.38 | 9.96 | 576 | 136551 | 57166 | 56097774 |
Suspected suicide | 336.47 | 9.96 | 193 | 136934 | 5273 | 56149667 |
Cardio-respiratory arrest | 329.73 | 9.96 | 529 | 136598 | 54792 | 56100148 |
Product substitution issue | 294.98 | 9.96 | 261 | 136866 | 14338 | 56140602 |
Serotonin syndrome | 283.20 | 9.96 | 336 | 136791 | 26154 | 56128786 |
Suicide attempt | 259.60 | 9.96 | 488 | 136639 | 57348 | 56097592 |
Electrocardiogram QRS complex prolonged | 243.74 | 9.96 | 157 | 136970 | 5310 | 56149630 |
Cardiac arrest | 232.65 | 9.96 | 593 | 136534 | 85721 | 56069219 |
Temperature regulation disorder | 228.55 | 9.96 | 140 | 136987 | 4328 | 56150612 |
Agitation | 218.90 | 9.96 | 446 | 136681 | 55590 | 56099350 |
Status epilepticus | 213.48 | 9.96 | 222 | 136905 | 14919 | 56140021 |
Irritability | 183.20 | 9.96 | 288 | 136839 | 29300 | 56125640 |
Respiratory arrest | 177.15 | 9.96 | 289 | 136838 | 30336 | 56124604 |
Swelling | 176.81 | 9.96 | 194 | 136933 | 239577 | 55915363 |
Sleep apnoea syndrome | 173.03 | 9.96 | 262 | 136865 | 25799 | 56129141 |
Drug withdrawal syndrome | 170.33 | 9.96 | 259 | 136868 | 25598 | 56129342 |
Mydriasis | 168.19 | 9.96 | 169 | 136958 | 10902 | 56144038 |
Food allergy | 155.26 | 9.96 | 146 | 136981 | 8678 | 56146262 |
Pemphigus | 153.06 | 9.96 | 97 | 137030 | 157115 | 55997825 |
Neutropenia | 152.06 | 9.96 | 99 | 137028 | 158068 | 55996872 |
Coeliac disease | 151.91 | 9.96 | 155 | 136972 | 10184 | 56144756 |
Sensitisation | 149.46 | 9.96 | 85 | 137042 | 2283 | 56152657 |
Hyperhidrosis | 148.90 | 9.96 | 536 | 136591 | 93552 | 56061388 |
Arthropathy | 148.77 | 9.96 | 161 | 136966 | 200114 | 55954826 |
Systemic lupus erythematosus | 146.10 | 9.96 | 134 | 136993 | 179944 | 55974996 |
Tremor | 145.74 | 9.96 | 633 | 136494 | 120456 | 56034484 |
Polycystic ovaries | 144.85 | 9.96 | 94 | 137033 | 3220 | 56151720 |
Anaemia | 142.53 | 9.96 | 272 | 136855 | 267239 | 55887701 |
Thrombocytopenia | 139.69 | 9.96 | 79 | 137048 | 136145 | 56018795 |
Poisoning | 137.70 | 9.96 | 163 | 136964 | 12650 | 56142290 |
Pyrexia | 137.47 | 9.96 | 540 | 136587 | 418233 | 55736707 |
White blood cell count abnormal | 132.91 | 9.96 | 112 | 137015 | 5755 | 56149185 |
Electrocardiogram QT prolonged | 132.70 | 9.96 | 361 | 136766 | 54227 | 56100713 |
Asthma | 131.51 | 9.96 | 584 | 136543 | 112186 | 56042754 |
Sinus tachycardia | 127.37 | 9.96 | 210 | 136917 | 22234 | 56132706 |
Acute kidney injury | 127.19 | 9.96 | 246 | 136881 | 240517 | 55914423 |
Febrile neutropenia | 125.39 | 9.96 | 50 | 137077 | 105495 | 56049445 |
Immunodeficiency | 124.05 | 9.96 | 174 | 136953 | 15983 | 56138957 |
Ejection fraction | 123.11 | 9.96 | 67 | 137060 | 1648 | 56153292 |
Helicobacter infection | 121.60 | 9.96 | 17 | 137110 | 73251 | 56081689 |
Peripheral swelling | 119.54 | 9.96 | 245 | 136882 | 234481 | 55920459 |
Glossodynia | 118.33 | 9.96 | 118 | 137009 | 152340 | 56002600 |
Duodenal ulcer perforation | 113.09 | 9.96 | 16 | 137111 | 68326 | 56086614 |
Headache | 110.63 | 9.96 | 1943 | 135184 | 557101 | 55597839 |
Joint swelling | 110.15 | 9.96 | 351 | 136776 | 289449 | 55865491 |
Insomnia | 107.13 | 9.96 | 817 | 136310 | 191043 | 55963897 |
Pancytopenia | 107.07 | 9.96 | 41 | 137086 | 88674 | 56066266 |
Hand deformity | 105.62 | 9.96 | 103 | 137024 | 134389 | 56020551 |
Muscle injury | 103.59 | 9.96 | 6 | 137121 | 52494 | 56102446 |
Drug hypersensitivity | 101.73 | 9.96 | 1071 | 136056 | 274134 | 55880806 |
Withdrawal syndrome | 99.76 | 9.96 | 169 | 136958 | 18293 | 56136647 |
Cardiac failure | 98.97 | 9.96 | 38 | 137089 | 82055 | 56072885 |
Lower respiratory tract infection | 97.18 | 9.96 | 82 | 137045 | 114712 | 56040228 |
Therapeutic response unexpected | 96.07 | 9.96 | 159 | 136968 | 16885 | 56138055 |
Drug abuse | 95.95 | 9.96 | 372 | 136755 | 67238 | 56087702 |
Maternal exposure during pregnancy | 95.50 | 9.96 | 199 | 136928 | 189354 | 55965586 |
Folliculitis | 95.49 | 9.96 | 11 | 137116 | 54968 | 56099972 |
Blister | 94.38 | 9.96 | 76 | 137051 | 108811 | 56046129 |
Anger | 93.04 | 9.96 | 128 | 136999 | 11544 | 56143396 |
Feeling abnormal | 92.76 | 9.96 | 600 | 136527 | 133002 | 56021938 |
Infusion related reaction | 92.63 | 9.96 | 235 | 136892 | 208696 | 55946244 |
Foot deformity | 89.89 | 9.96 | 187 | 136940 | 23638 | 56131302 |
General physical health deterioration | 88.60 | 9.96 | 175 | 136952 | 169835 | 55985105 |
Treatment failure | 86.57 | 9.96 | 178 | 136949 | 170214 | 55984726 |
Infarction | 86.30 | 9.96 | 61 | 137066 | 2410 | 56152530 |
Joint dislocation | 84.71 | 9.96 | 144 | 136983 | 15629 | 56139311 |
Retinitis | 84.28 | 9.96 | 75 | 137052 | 4149 | 56150791 |
Malignant neoplasm progression | 83.95 | 9.96 | 37 | 137090 | 73550 | 56081390 |
Exposure via ingestion | 83.73 | 9.96 | 63 | 137064 | 2745 | 56152195 |
Memory impairment | 83.22 | 9.96 | 424 | 136703 | 86133 | 56068807 |
Crying | 82.91 | 9.96 | 170 | 136957 | 21270 | 56133670 |
Exostosis | 81.02 | 9.96 | 137 | 136990 | 14806 | 56140134 |
Product odour abnormal | 78.27 | 9.96 | 43 | 137084 | 1078 | 56153862 |
Myoclonus | 77.98 | 9.96 | 136 | 136991 | 15067 | 56139873 |
Tardive dyskinesia | 77.89 | 9.96 | 97 | 137030 | 7934 | 56147006 |
Dyspnoea | 76.05 | 9.96 | 1003 | 136124 | 591574 | 55563366 |
Sympathomimetic effect | 74.27 | 9.96 | 19 | 137108 | 39 | 56154901 |
Alopecia | 73.97 | 9.96 | 416 | 136711 | 293042 | 55861898 |
Rash | 73.74 | 9.96 | 807 | 136320 | 492240 | 55662700 |
Atrial fibrillation | 71.80 | 9.96 | 96 | 137031 | 108801 | 56046139 |
Pericarditis | 70.83 | 9.96 | 97 | 137030 | 108826 | 56046114 |
Rhinitis allergic | 70.68 | 9.96 | 95 | 137032 | 8379 | 56146561 |
Migraine | 70.46 | 9.96 | 406 | 136721 | 86391 | 56068549 |
Mental status changes | 70.13 | 9.96 | 226 | 136901 | 37275 | 56117665 |
Abdominal discomfort | 69.36 | 9.96 | 394 | 136733 | 276880 | 55878060 |
Lupus-like syndrome | 68.79 | 9.96 | 115 | 137012 | 12312 | 56142628 |
Bursitis | 68.60 | 9.96 | 184 | 136943 | 27398 | 56127542 |
Disturbance in attention | 67.22 | 9.96 | 203 | 136924 | 32337 | 56122603 |
Pulseless electrical activity | 66.78 | 9.96 | 84 | 137043 | 6940 | 56148000 |
Gastrointestinal disorder | 65.88 | 9.96 | 108 | 137019 | 112594 | 56042346 |
Postmortem blood drug level increased | 65.55 | 9.96 | 31 | 137096 | 561 | 56154379 |
Diarrhoea | 65.34 | 9.96 | 1129 | 135998 | 637378 | 55517562 |
Postictal state | 64.66 | 9.96 | 36 | 137091 | 927 | 56154013 |
Disease progression | 63.16 | 9.96 | 99 | 137028 | 105074 | 56049866 |
Impaired healing | 62.02 | 9.96 | 72 | 137055 | 86769 | 56068171 |
Bone erosion | 61.80 | 9.96 | 122 | 137005 | 14852 | 56140088 |
Product residue present | 61.47 | 9.96 | 60 | 137067 | 3735 | 56151205 |
Platelet count decreased | 61.20 | 9.96 | 103 | 137024 | 106280 | 56048660 |
Panic attack | 60.85 | 9.96 | 146 | 136981 | 20301 | 56134639 |
Cholecystitis chronic | 60.48 | 9.96 | 95 | 137032 | 9653 | 56145287 |
Stomatitis | 59.83 | 9.96 | 128 | 136999 | 120682 | 56034258 |
Bronchial neoplasm | 59.59 | 9.96 | 27 | 137100 | 441 | 56154499 |
Cerebral venous thrombosis | 59.45 | 9.96 | 44 | 137083 | 1869 | 56153071 |
Hepatic cirrhosis | 59.21 | 9.96 | 148 | 136979 | 21115 | 56133825 |
Nicotine dependence | 57.41 | 9.96 | 30 | 137097 | 678 | 56154262 |
Bipolar disorder | 57.24 | 9.96 | 81 | 137046 | 7499 | 56147441 |
Nephrectomy | 56.96 | 9.96 | 36 | 137091 | 1177 | 56153763 |
Bone marrow failure | 56.52 | 9.96 | 3 | 137124 | 28283 | 56126657 |
Mental disorder | 56.24 | 9.96 | 155 | 136972 | 23449 | 56131491 |
Sepsis | 56.15 | 9.96 | 165 | 136962 | 139675 | 56015265 |
Hallucinations, mixed | 55.53 | 9.96 | 61 | 137066 | 4363 | 56150577 |
Bronchial haemorrhage | 55.11 | 9.96 | 27 | 137100 | 530 | 56154410 |
Anti-cyclic citrullinated peptide antibody positive | 54.41 | 9.96 | 98 | 137029 | 98502 | 56056438 |
Hyperkalaemia | 54.30 | 9.96 | 28 | 137099 | 50837 | 56104103 |
Tachycardia | 54.14 | 9.96 | 442 | 136685 | 105434 | 56049506 |
Sleep-related eating disorder | 53.83 | 9.96 | 30 | 137097 | 774 | 56154166 |
Psoriasis | 53.50 | 9.96 | 398 | 136729 | 92294 | 56062646 |
Multiple organ dysfunction syndrome | 53.49 | 9.96 | 31 | 137096 | 52739 | 56102201 |
Carpal tunnel syndrome | 53.40 | 9.96 | 129 | 136998 | 18015 | 56136925 |
Hepatocellular injury | 52.39 | 9.96 | 3 | 137124 | 26511 | 56128429 |
Synovitis | 52.12 | 9.96 | 209 | 136918 | 161096 | 55993844 |
Asthma exercise induced | 51.44 | 9.96 | 21 | 137106 | 262 | 56154678 |
Areflexia | 51.40 | 9.96 | 48 | 137079 | 2827 | 56152113 |
Weight increased | 51.27 | 9.96 | 815 | 136312 | 228888 | 55926052 |
Brain injury | 51.12 | 9.96 | 70 | 137057 | 6285 | 56148655 |
Hyponatraemia | 50.75 | 9.96 | 108 | 137019 | 102031 | 56052909 |
Hallucination | 50.22 | 9.96 | 245 | 136882 | 48904 | 56106036 |
Factor V Leiden mutation | 49.93 | 9.96 | 19 | 137108 | 194 | 56154746 |
C-reactive protein abnormal | 49.69 | 9.96 | 14 | 137113 | 36795 | 56118145 |
Mucosal inflammation | 49.66 | 9.96 | 21 | 137106 | 42789 | 56112151 |
Discomfort | 49.47 | 9.96 | 178 | 136949 | 141583 | 56013357 |
Neutrophil count decreased | 49.47 | 9.96 | 30 | 137097 | 49792 | 56105148 |
Rubber sensitivity | 49.45 | 9.96 | 40 | 137087 | 1940 | 56153000 |
Renal impairment | 49.39 | 9.96 | 75 | 137052 | 80638 | 56074302 |
Sleep disorder due to general medical condition, insomnia type | 49.09 | 9.96 | 22 | 137105 | 43316 | 56111624 |
Nasal turbinate hypertrophy | 48.82 | 9.96 | 27 | 137100 | 686 | 56154254 |
Persistent genital arousal disorder | 48.57 | 9.96 | 21 | 137106 | 305 | 56154635 |
Major depression | 48.57 | 9.96 | 75 | 137052 | 7509 | 56147431 |
Emotional distress | 48.26 | 9.96 | 171 | 136956 | 29592 | 56125348 |
Rash erythematous | 47.36 | 9.96 | 198 | 136929 | 37023 | 56117917 |
Haemoglobin decreased | 47.09 | 9.96 | 168 | 136959 | 133969 | 56020971 |
Hepatic function abnormal | 46.92 | 9.96 | 13 | 137114 | 34545 | 56120395 |
Wound | 46.65 | 9.96 | 177 | 136950 | 138627 | 56016313 |
Cardiogenic shock | 45.85 | 9.96 | 114 | 137013 | 16211 | 56138729 |
Irritable bowel syndrome | 45.47 | 9.96 | 60 | 137067 | 68398 | 56086542 |
Endometrial ablation | 45.37 | 9.96 | 28 | 137099 | 877 | 56154063 |
Liver disorder | 45.06 | 9.96 | 26 | 137101 | 44344 | 56110596 |
Therapeutic product effect incomplete | 45.04 | 9.96 | 425 | 136702 | 105606 | 56049334 |
Thermal burn | 45.00 | 9.96 | 61 | 137066 | 5424 | 56149516 |
Hypothyroidism | 44.61 | 9.96 | 198 | 136929 | 37998 | 56116942 |
Nasopharyngitis | 44.55 | 9.96 | 335 | 136792 | 220624 | 55934316 |
Leukopenia | 44.30 | 9.96 | 65 | 137062 | 70875 | 56084065 |
Fibromyalgia | 44.00 | 9.96 | 272 | 136855 | 59331 | 56095609 |
Multiple sclerosis relapse | 43.86 | 9.96 | 221 | 136906 | 44682 | 56110258 |
Arthralgia | 43.81 | 9.96 | 911 | 136216 | 500758 | 55654182 |
Mood altered | 43.72 | 9.96 | 99 | 137028 | 13256 | 56141684 |
Hostility | 43.64 | 9.96 | 36 | 137091 | 1795 | 56153145 |
Brugada syndrome | 43.53 | 9.96 | 20 | 137107 | 338 | 56154602 |
Thinking abnormal | 43.47 | 9.96 | 83 | 137044 | 9858 | 56145082 |
Blood test abnormal | 43.23 | 9.96 | 96 | 137031 | 12688 | 56142252 |
Intentional product misuse | 43.15 | 9.96 | 243 | 136884 | 51261 | 56103679 |
Oesophageal spasm | 42.97 | 9.96 | 43 | 137084 | 2759 | 56152181 |
Cholestasis | 42.91 | 9.96 | 7 | 137120 | 26906 | 56128034 |
Libido increased | 42.63 | 9.96 | 31 | 137096 | 1281 | 56153659 |
Affective disorder | 42.50 | 9.96 | 60 | 137067 | 5543 | 56149397 |
Hyperreflexia | 42.48 | 9.96 | 58 | 137069 | 5192 | 56149748 |
Depressed mood | 42.10 | 9.96 | 188 | 136939 | 36171 | 56118769 |
Fluid retention | 41.96 | 9.96 | 250 | 136877 | 53828 | 56101112 |
Product complaint | 41.69 | 9.96 | 90 | 137037 | 11670 | 56143270 |
White blood cell count decreased | 41.48 | 9.96 | 162 | 136965 | 125828 | 56029112 |
Gastrointestinal haemorrhage | 41.44 | 9.96 | 76 | 137051 | 75875 | 56079065 |
Nightmare | 40.59 | 9.96 | 111 | 137016 | 16715 | 56138225 |
Lung disorder | 40.44 | 9.96 | 41 | 137086 | 52556 | 56102384 |
Pruritus | 40.06 | 9.96 | 537 | 136590 | 316086 | 55838854 |
Vertigo | 39.63 | 9.96 | 248 | 136879 | 54324 | 56100616 |
Pre-existing condition improved | 39.01 | 9.96 | 67 | 137060 | 7331 | 56147609 |
Hallucination, auditory | 38.37 | 9.96 | 86 | 137041 | 11438 | 56143502 |
Muscle twitching | 38.04 | 9.96 | 106 | 137021 | 16136 | 56138804 |
Abnormal dreams | 37.88 | 9.96 | 77 | 137050 | 9572 | 56145368 |
Impulse-control disorder | 37.86 | 9.96 | 23 | 137104 | 700 | 56154240 |
Upper respiratory tract infection | 37.73 | 9.96 | 300 | 136827 | 70988 | 56083952 |
Sleep disorder due to a general medical condition | 37.44 | 9.96 | 74 | 137053 | 9016 | 56145924 |
Pleural effusion | 37.17 | 9.96 | 97 | 137030 | 85383 | 56069557 |
Pneumonia | 37.07 | 9.96 | 734 | 136393 | 406364 | 55748576 |
Bruxism | 36.90 | 9.96 | 42 | 137085 | 3124 | 56151816 |
Bronchial disorder | 36.29 | 9.96 | 27 | 137100 | 1156 | 56153784 |
Oesophageal pain | 35.74 | 9.96 | 42 | 137085 | 3233 | 56151707 |
Laryngitis | 35.72 | 9.96 | 94 | 137033 | 13836 | 56141104 |
Hypokalaemia | 35.36 | 9.96 | 115 | 137012 | 94322 | 56060618 |
Endometriosis | 35.14 | 9.96 | 50 | 137077 | 4652 | 56150288 |
Akathisia | 35.11 | 9.96 | 70 | 137057 | 8582 | 56146358 |
Gastrooesophageal reflux disease | 35.00 | 9.96 | 333 | 136794 | 82924 | 56072016 |
Hypoglycaemia | 34.98 | 9.96 | 51 | 137076 | 55764 | 56099176 |
Sleep paralysis | 34.71 | 9.96 | 20 | 137107 | 551 | 56154389 |
Burning sensation | 33.93 | 9.96 | 219 | 136908 | 48477 | 56106463 |
Pupil fixed | 33.70 | 9.96 | 30 | 137097 | 1660 | 56153280 |
Hepatic failure | 33.47 | 9.96 | 20 | 137107 | 33466 | 56121474 |
Dizziness | 33.25 | 9.96 | 1173 | 135954 | 374967 | 55779973 |
Septic shock | 33.08 | 9.96 | 61 | 137066 | 60774 | 56094166 |
Mania | 32.93 | 9.96 | 81 | 137046 | 11439 | 56143501 |
Treatment noncompliance | 32.88 | 9.96 | 162 | 136965 | 32461 | 56122479 |
Feeling jittery | 32.65 | 9.96 | 83 | 137044 | 11963 | 56142977 |
Drug eruption | 32.61 | 9.96 | 11 | 137116 | 25752 | 56129188 |
Stress | 32.32 | 9.96 | 250 | 136877 | 58660 | 56096280 |
Vision blurred | 32.06 | 9.96 | 326 | 136801 | 82617 | 56072323 |
Choreoathetosis | 31.87 | 9.96 | 18 | 137109 | 477 | 56154463 |
Death | 31.85 | 9.96 | 613 | 136514 | 340813 | 55814127 |
Liver injury | 31.74 | 9.96 | 33 | 137094 | 41815 | 56113125 |
Libido decreased | 31.61 | 9.96 | 34 | 137093 | 2374 | 56152566 |
Obsessive-compulsive disorder | 31.60 | 9.96 | 42 | 137085 | 3664 | 56151276 |
Tinnitus | 31.58 | 9.96 | 151 | 136976 | 29891 | 56125049 |
Epistaxis | 31.54 | 9.96 | 73 | 137054 | 66950 | 56087990 |
Ejection fraction abnormal | 31.30 | 9.96 | 24 | 137103 | 1076 | 56153864 |
Sputum purulent | 31.16 | 9.96 | 23 | 137104 | 973 | 56153967 |
International normalised ratio increased | 30.91 | 9.96 | 37 | 137090 | 44004 | 56110936 |
Drug intolerance | 30.69 | 9.96 | 457 | 136670 | 264361 | 55890579 |
Drug screen positive | 30.69 | 9.96 | 40 | 137087 | 3424 | 56151516 |
Rheumatic fever | 30.57 | 9.96 | 16 | 137111 | 28811 | 56126129 |
Economic problem | 30.55 | 9.96 | 30 | 137097 | 1881 | 56153059 |
Ascites | 30.33 | 9.96 | 28 | 137099 | 37516 | 56117424 |
Gamma-glutamyltransferase increased | 30.32 | 9.96 | 19 | 137108 | 30986 | 56123954 |
Hypercalcaemia | 30.22 | 9.96 | 12 | 137115 | 25399 | 56129541 |
Tachyphrenia | 30.09 | 9.96 | 25 | 137102 | 1259 | 56153681 |
Plasma cell myeloma | 29.85 | 9.96 | 42 | 137085 | 46604 | 56108336 |
Anti-neutrophil cytoplasmic antibody positive vasculitis | 29.66 | 9.96 | 34 | 137093 | 2549 | 56152391 |
Anorgasmia | 29.65 | 9.96 | 18 | 137109 | 547 | 56154393 |
Gambling disorder | 29.26 | 9.96 | 24 | 137103 | 1187 | 56153753 |
Myelodysplastic syndrome | 29.20 | 9.96 | 3 | 137124 | 16403 | 56138537 |
Binge eating | 28.98 | 9.96 | 16 | 137111 | 405 | 56154535 |
Cerebral haemorrhage | 28.71 | 9.96 | 17 | 137110 | 28589 | 56126351 |
Anhedonia | 28.65 | 9.96 | 70 | 137057 | 9844 | 56145096 |
Toxic epidermal necrolysis | 28.63 | 9.96 | 9 | 137118 | 22033 | 56132907 |
Dyskinesia | 28.24 | 9.96 | 143 | 136984 | 28965 | 56125975 |
Product quality issue | 28.09 | 9.96 | 152 | 136975 | 31584 | 56123356 |
Somnolence | 27.94 | 9.96 | 556 | 136571 | 162857 | 55992083 |
Amnesia | 27.91 | 9.96 | 201 | 136926 | 46121 | 56108819 |
Renal disorder | 27.72 | 9.96 | 144 | 136983 | 29461 | 56125479 |
Jaundice | 27.71 | 9.96 | 16 | 137111 | 27278 | 56127662 |
Central nervous system necrosis | 27.63 | 9.96 | 11 | 137116 | 128 | 56154812 |
Urine sodium increased | 27.49 | 9.96 | 10 | 137117 | 89 | 56154851 |
Automatism | 27.39 | 9.96 | 9 | 137118 | 57 | 56154883 |
Restless legs syndrome | 27.16 | 9.96 | 97 | 137030 | 16850 | 56138090 |
Renal failure | 27.04 | 9.96 | 158 | 136969 | 110342 | 56044598 |
Electroencephalogram abnormal | 26.99 | 9.96 | 38 | 137089 | 3501 | 56151439 |
Joint stiffness | 26.98 | 9.96 | 163 | 136964 | 35262 | 56119678 |
Secondary immunodeficiency | 26.71 | 9.96 | 23 | 137104 | 1217 | 56153723 |
Infection | 26.59 | 9.96 | 336 | 136791 | 199870 | 55955070 |
Rash maculo-papular | 26.54 | 9.96 | 19 | 137108 | 28888 | 56126052 |
Nervousness | 26.38 | 9.96 | 140 | 136987 | 28875 | 56126065 |
Asthenia | 26.12 | 9.96 | 636 | 136491 | 342337 | 55812603 |
Brain death | 25.73 | 9.96 | 34 | 137093 | 2949 | 56151991 |
Ventricular tachycardia | 25.62 | 9.96 | 95 | 137032 | 16806 | 56138134 |
Mucosal dryness | 25.56 | 9.96 | 31 | 137096 | 2467 | 56152473 |
Melaena | 25.44 | 9.96 | 19 | 137108 | 28271 | 56126669 |
Sexual dysfunction | 25.28 | 9.96 | 36 | 137091 | 3352 | 56151588 |
Decreased interest | 25.18 | 9.96 | 34 | 137093 | 3012 | 56151928 |
Urine osmolarity increased | 25.14 | 9.96 | 10 | 137117 | 116 | 56154824 |
Reversible cerebral vasoconstriction syndrome | 25.14 | 9.96 | 30 | 137097 | 2347 | 56152593 |
Haematemesis | 24.99 | 9.96 | 20 | 137107 | 28738 | 56126202 |
Agranulocytosis | 24.89 | 9.96 | 12 | 137115 | 22647 | 56132293 |
Product dose omission issue | 24.86 | 9.96 | 664 | 136463 | 204089 | 55950851 |
Syncope | 24.76 | 9.96 | 158 | 136969 | 108041 | 56046899 |
Dyspnoea exertional | 24.59 | 9.96 | 61 | 137066 | 54628 | 56100312 |
Neoplasm progression | 24.56 | 9.96 | 25 | 137102 | 31991 | 56122949 |
Osteonecrosis of jaw | 24.52 | 9.96 | 27 | 137100 | 33331 | 56121609 |
Multiple sclerosis | 24.50 | 9.96 | 133 | 136994 | 27669 | 56127271 |
Thalamic infarction | 24.39 | 9.96 | 15 | 137112 | 467 | 56154473 |
Off label use | 24.22 | 9.96 | 1108 | 136019 | 555072 | 55599868 |
Blood lactate dehydrogenase increased | 24.20 | 9.96 | 10 | 137117 | 20665 | 56134275 |
Unresponsive to stimuli | 24.18 | 9.96 | 146 | 136981 | 31579 | 56123361 |
Feeling of despair | 24.15 | 9.96 | 28 | 137099 | 2125 | 56152815 |
Attention deficit hyperactivity disorder | 24.06 | 9.96 | 31 | 137096 | 2623 | 56152317 |
Macular degeneration | 24.06 | 9.96 | 8 | 137119 | 18900 | 56136040 |
Ill-defined disorder | 23.94 | 9.96 | 86 | 137041 | 68457 | 56086483 |
Post-traumatic stress disorder | 23.80 | 9.96 | 41 | 137086 | 4497 | 56150443 |
Large intestine anastomosis | 23.75 | 9.96 | 7 | 137120 | 29 | 56154911 |
Affect lability | 23.63 | 9.96 | 66 | 137061 | 10059 | 56144881 |
Posterior reversible encephalopathy syndrome | 23.63 | 9.96 | 5 | 137122 | 15955 | 56138985 |
Adrenergic syndrome | 23.56 | 9.96 | 7 | 137120 | 30 | 56154910 |
Soft tissue injury | 23.54 | 9.96 | 24 | 137103 | 1575 | 56153365 |
Lactic acidosis | 23.45 | 9.96 | 31 | 137096 | 35315 | 56119625 |
Erythema dyschromicum perstans | 23.42 | 9.96 | 8 | 137119 | 58 | 56154882 |
Swollen joint count increased | 23.40 | 9.96 | 15 | 137112 | 24169 | 56130771 |
Drug specific antibody | 23.24 | 9.96 | 27 | 137100 | 2053 | 56152887 |
Hepatotoxicity | 23.14 | 9.96 | 25 | 137102 | 31128 | 56123812 |
Dissociation | 23.13 | 9.96 | 30 | 137097 | 2555 | 56152385 |
Haemorrhage | 23.02 | 9.96 | 66 | 137061 | 56331 | 56098609 |
Supraventricular tachycardia | 22.97 | 9.96 | 78 | 137049 | 13213 | 56141727 |
Nausea | 22.92 | 9.96 | 2159 | 134968 | 762019 | 55392921 |
Dysphemia | 22.72 | 9.96 | 29 | 137098 | 2431 | 56152509 |
Myoglobinuria | 22.66 | 9.96 | 12 | 137115 | 279 | 56154661 |
Hip arthroplasty | 22.57 | 9.96 | 37 | 137090 | 38586 | 56116354 |
Drug tolerance decreased | 22.51 | 9.96 | 3 | 137124 | 13408 | 56141532 |
Interstitial lung disease | 22.40 | 9.96 | 68 | 137059 | 56995 | 56097945 |
Hypomagnesaemia | 22.24 | 9.96 | 17 | 137110 | 24998 | 56129942 |
Peritonitis | 22.17 | 9.96 | 6 | 137121 | 16196 | 56138744 |
Oppositional defiant disorder | 22.06 | 9.96 | 7 | 137120 | 39 | 56154901 |
Accidental exposure to product by child | 21.78 | 9.96 | 20 | 137107 | 1153 | 56153787 |
Rhonchi | 21.67 | 9.96 | 28 | 137099 | 2376 | 56152564 |
Hepatitis | 21.61 | 9.96 | 33 | 137094 | 35408 | 56119532 |
Heart rate decreased | 21.56 | 9.96 | 41 | 137086 | 40386 | 56114554 |
Complication of device insertion | 21.45 | 9.96 | 48 | 137079 | 6376 | 56148564 |
Rheumatoid arthritis | 21.43 | 9.96 | 740 | 136387 | 381864 | 55773076 |
Mood swings | 21.23 | 9.96 | 89 | 137038 | 16658 | 56138282 |
Paranoia | 21.23 | 9.96 | 66 | 137061 | 10678 | 56144262 |
Product use issue | 21.21 | 9.96 | 322 | 136805 | 185719 | 55969221 |
Cardiac disorder | 21.03 | 9.96 | 187 | 136940 | 45700 | 56109240 |
Compulsive shopping | 20.99 | 9.96 | 16 | 137111 | 711 | 56154229 |
Hypotonic urinary bladder | 20.74 | 9.96 | 5 | 137122 | 7 | 56154933 |
Corneal reflex decreased | 20.74 | 9.96 | 9 | 137118 | 132 | 56154808 |
Rhinitis | 20.69 | 9.96 | 58 | 137069 | 8858 | 56146082 |
Dystonia | 20.68 | 9.96 | 72 | 137055 | 12349 | 56142591 |
Oedema | 20.65 | 9.96 | 116 | 137011 | 81804 | 56073136 |
Pneumonitis | 20.61 | 9.96 | 28 | 137099 | 31536 | 56123404 |
Impaired work ability | 20.51 | 9.96 | 80 | 137047 | 14492 | 56140448 |
Cerebral infarction | 20.39 | 9.96 | 15 | 137112 | 22490 | 56132450 |
Disseminated intravascular coagulation | 20.38 | 9.96 | 9 | 137118 | 17876 | 56137064 |
Solar urticaria | 20.34 | 9.96 | 7 | 137120 | 52 | 56154888 |
Urine amphetamine positive | 20.34 | 9.96 | 7 | 137120 | 52 | 56154888 |
Biliary dyskinesia | 20.26 | 9.96 | 28 | 137099 | 2535 | 56152405 |
Metastases to liver | 20.06 | 9.96 | 14 | 137113 | 21572 | 56133368 |
Narcolepsy | 19.91 | 9.96 | 20 | 137107 | 1289 | 56153651 |
Sternal fracture | 19.88 | 9.96 | 25 | 137102 | 2065 | 56152875 |
Musculoskeletal pain | 19.87 | 9.96 | 116 | 137011 | 81036 | 56073904 |
Anticholinergic syndrome | 19.79 | 9.96 | 24 | 137103 | 1910 | 56153030 |
Neuropathy peripheral | 19.77 | 9.96 | 158 | 136969 | 102735 | 56052205 |
Liver function test abnormal | 19.72 | 9.96 | 52 | 137075 | 45619 | 56109321 |
Apathy | 19.71 | 9.96 | 53 | 137074 | 7901 | 56147039 |
Caput succedaneum | 19.63 | 9.96 | 5 | 137122 | 10 | 56154930 |
Self esteem decreased | 19.52 | 9.96 | 14 | 137113 | 566 | 56154374 |
Emotional disorder | 19.38 | 9.96 | 70 | 137057 | 12225 | 56142715 |
Tongue biting | 19.35 | 9.96 | 20 | 137107 | 1334 | 56153606 |
Cardiomyopathy acute | 19.26 | 9.96 | 10 | 137117 | 223 | 56154717 |
Respiratory failure | 19.19 | 9.96 | 144 | 136983 | 94918 | 56060022 |
Mass excision | 19.12 | 9.96 | 11 | 137116 | 302 | 56154638 |
Blood creatinine increased | 18.91 | 9.96 | 116 | 137011 | 80075 | 56074865 |
Gallbladder disorder | 18.85 | 9.96 | 88 | 137039 | 17246 | 56137694 |
Blood pressure systolic increased | 18.79 | 9.96 | 45 | 137082 | 40791 | 56114149 |
Alcoholism | 18.78 | 9.96 | 25 | 137102 | 2184 | 56152756 |
Upper gastrointestinal haemorrhage | 18.78 | 9.96 | 9 | 137118 | 17045 | 56137895 |
Sexually inappropriate behaviour | 18.58 | 9.96 | 8 | 137119 | 115 | 56154825 |
Femur fracture | 18.32 | 9.96 | 43 | 137084 | 39252 | 56115688 |
Dysphoria | 18.25 | 9.96 | 38 | 137089 | 4804 | 56150136 |
Tenosynovitis | 18.25 | 9.96 | 4 | 137123 | 12457 | 56142483 |
Sensitivity to weather change | 18.22 | 9.96 | 46 | 137081 | 6603 | 56148337 |
Haemoglobin urine | 18.15 | 9.96 | 8 | 137119 | 122 | 56154818 |
Job dissatisfaction | 18.13 | 9.96 | 6 | 137121 | 39 | 56154901 |
Somnambulism | 18.08 | 9.96 | 39 | 137088 | 5053 | 56149887 |
Drug tolerance | 18.05 | 9.96 | 43 | 137084 | 5951 | 56148989 |
Skin necrosis | 18.04 | 9.96 | 4 | 137123 | 12357 | 56142583 |
Urinary tract infection | 18.01 | 9.96 | 447 | 136680 | 240066 | 55914874 |
Drug dependence | 18.01 | 9.96 | 105 | 137022 | 22428 | 56132512 |
Clonus | 17.99 | 9.96 | 35 | 137092 | 4214 | 56150726 |
Haemangioma congenital | 17.91 | 9.96 | 12 | 137115 | 434 | 56154506 |
Uterine perforation | 17.82 | 9.96 | 45 | 137082 | 6460 | 56148480 |
Post-traumatic neck syndrome | 17.77 | 9.96 | 23 | 137104 | 1955 | 56152985 |
Premature delivery | 17.68 | 9.96 | 24 | 137103 | 27036 | 56127904 |
Cough | 17.66 | 9.96 | 490 | 136637 | 259471 | 55895469 |
Oscillopsia | 17.64 | 9.96 | 8 | 137119 | 131 | 56154809 |
Blood bilirubin increased | 17.64 | 9.96 | 34 | 137093 | 33320 | 56121620 |
Drug titration error | 17.47 | 9.96 | 14 | 137113 | 670 | 56154270 |
Skin ulcer | 17.41 | 9.96 | 43 | 137084 | 38565 | 56116375 |
Euphoric mood | 17.37 | 9.96 | 35 | 137092 | 4323 | 56150617 |
Liver function test increased | 17.34 | 9.96 | 26 | 137101 | 28107 | 56126833 |
Product coating issue | 17.27 | 9.96 | 6 | 137121 | 46 | 56154894 |
Device dislocation | 17.20 | 9.96 | 104 | 137023 | 22502 | 56132438 |
Loss of libido | 17.20 | 9.96 | 18 | 137109 | 1218 | 56153722 |
Knee arthroplasty | 17.19 | 9.96 | 53 | 137074 | 44206 | 56110734 |
Acute myeloid leukaemia | 17.15 | 9.96 | 10 | 137117 | 16962 | 56137978 |
Premature baby | 17.14 | 9.96 | 13 | 137114 | 19192 | 56135748 |
Sedation | 16.99 | 9.96 | 144 | 136983 | 34710 | 56120230 |
Infusion site scar | 16.97 | 9.96 | 11 | 137116 | 376 | 56154564 |
Forced expiratory volume decreased | 16.90 | 9.96 | 36 | 137091 | 4624 | 56150316 |
Cortisol increased | 16.79 | 9.96 | 11 | 137116 | 383 | 56154557 |
Herpes zoster | 16.76 | 9.96 | 112 | 137015 | 75777 | 56079163 |
Dermatillomania | 16.76 | 9.96 | 8 | 137119 | 148 | 56154792 |
Cardiac failure congestive | 16.71 | 9.96 | 135 | 136992 | 87585 | 56067355 |
Metastases to bone | 16.42 | 9.96 | 14 | 137113 | 19494 | 56135446 |
Pulmonary hypertension | 16.23 | 9.96 | 40 | 137087 | 35904 | 56119036 |
Right ventricular systolic pressure decreased | 16.20 | 9.96 | 5 | 137122 | 25 | 56154915 |
Exposure via breast milk | 16.17 | 9.96 | 21 | 137106 | 1791 | 56153149 |
Iron deficiency anaemia | 16.16 | 9.96 | 12 | 137115 | 17907 | 56137033 |
Subacute cutaneous lupus erythematosus | 16.13 | 9.96 | 24 | 137103 | 2325 | 56152615 |
Hypertensive crisis | 16.09 | 9.96 | 7 | 137120 | 14029 | 56140911 |
Abnormal behaviour | 15.90 | 9.96 | 94 | 137033 | 20178 | 56134762 |
Pulmonary arterial hypertension | 15.85 | 9.96 | 25 | 137102 | 26478 | 56128462 |
Restlessness | 15.81 | 9.96 | 115 | 137012 | 26471 | 56128469 |
Polyneuropathy | 15.79 | 9.96 | 6 | 137121 | 13044 | 56141896 |
Gastrointestinal sounds abnormal | 15.70 | 9.96 | 31 | 137096 | 3774 | 56151166 |
Encephalopathy | 15.69 | 9.96 | 143 | 136984 | 35182 | 56119758 |
Haematuria | 15.63 | 9.96 | 26 | 137101 | 26961 | 56127979 |
Device placement issue | 15.28 | 9.96 | 15 | 137112 | 940 | 56154000 |
Vomiting | 15.28 | 9.96 | 1027 | 136100 | 497201 | 55657739 |
Angina pectoris | 15.25 | 9.96 | 28 | 137099 | 27948 | 56126992 |
Contraindicated product administered | 15.11 | 9.96 | 342 | 136785 | 185944 | 55968996 |
Contusion | 15.07 | 9.96 | 221 | 136906 | 128209 | 56026731 |
Orgasmic sensation decreased | 15.06 | 9.96 | 3 | 137124 | 0 | 56154940 |
Generalised anxiety disorder | 15.01 | 9.96 | 21 | 137106 | 1923 | 56153017 |
Hypervolaemia | 14.85 | 9.96 | 26 | 137101 | 26432 | 56128508 |
Panniculitis | 14.74 | 9.96 | 3 | 137124 | 9839 | 56145101 |
Wound infection fungal | 14.69 | 9.96 | 7 | 137120 | 129 | 56154811 |
Rheumatoid nodule | 14.67 | 9.96 | 9 | 137118 | 14848 | 56140092 |
Ulcer | 14.63 | 9.96 | 20 | 137107 | 22465 | 56132475 |
Ventricular tachyarrhythmia | 14.59 | 9.96 | 7 | 137120 | 131 | 56154809 |
Snoring | 14.56 | 9.96 | 29 | 137098 | 3552 | 56151388 |
Dysgraphia | 14.49 | 9.96 | 25 | 137102 | 2745 | 56152195 |
Palmar-plantar erythrodysaesthesia syndrome | 14.46 | 9.96 | 18 | 137109 | 21047 | 56133893 |
Breast cancer metastatic | 14.42 | 9.96 | 10 | 137117 | 15459 | 56139481 |
Sputum discoloured | 14.42 | 9.96 | 71 | 137056 | 14221 | 56140719 |
Balance disorder | 14.31 | 9.96 | 264 | 136863 | 76256 | 56078684 |
Decorticate posture | 14.25 | 9.96 | 9 | 137118 | 294 | 56154646 |
Colitis | 14.24 | 9.96 | 53 | 137074 | 41758 | 56113182 |
Visual impairment | 14.22 | 9.96 | 257 | 136870 | 73945 | 56080995 |
Cannabinoid hyperemesis syndrome | 14.21 | 9.96 | 5 | 137122 | 40 | 56154900 |
Lymphoedema | 14.17 | 9.96 | 57 | 137070 | 10473 | 56144467 |
Hypertonic bladder | 14.15 | 9.96 | 27 | 137100 | 3205 | 56151735 |
Impaired driving ability | 14.12 | 9.96 | 31 | 137096 | 4065 | 56150875 |
Pericardial effusion | 14.11 | 9.96 | 28 | 137099 | 27147 | 56127793 |
Homicidal ideation | 14.02 | 9.96 | 19 | 137108 | 1689 | 56153251 |
Dyspareunia | 13.98 | 9.96 | 22 | 137105 | 2238 | 56152702 |
Chronic fatigue syndrome | 13.92 | 9.96 | 15 | 137112 | 1050 | 56153890 |
Product solubility abnormal | 13.87 | 9.96 | 13 | 137114 | 769 | 56154171 |
Obesity | 13.86 | 9.96 | 98 | 137029 | 22350 | 56132590 |
Cerebrovascular accident | 13.77 | 9.96 | 165 | 136962 | 99105 | 56055835 |
Gestational diabetes | 13.65 | 9.96 | 47 | 137080 | 8017 | 56146923 |
Poor personal hygiene | 13.64 | 9.96 | 9 | 137118 | 317 | 56154623 |
Abscess sterile | 13.51 | 9.96 | 5 | 137122 | 47 | 56154893 |
Infusion site discomfort | 13.49 | 9.96 | 15 | 137112 | 1087 | 56153853 |
Ankle fracture | 13.47 | 9.96 | 77 | 137050 | 16326 | 56138614 |
Pelvic pain | 13.46 | 9.96 | 61 | 137066 | 11806 | 56143134 |
Cholelithiasis | 13.33 | 9.96 | 151 | 136976 | 39313 | 56115627 |
Pallor | 13.31 | 9.96 | 24 | 137103 | 24125 | 56130815 |
Antidepressant discontinuation syndrome | 13.30 | 9.96 | 4 | 137123 | 18 | 56154922 |
Clostridium difficile infection | 13.30 | 9.96 | 29 | 137098 | 27169 | 56127771 |
False positive investigation result | 13.29 | 9.96 | 11 | 137116 | 551 | 56154389 |
Wrong technique in product usage process | 13.17 | 9.96 | 207 | 136920 | 57961 | 56096979 |
Pupillary reflex impaired | 13.12 | 9.96 | 20 | 137107 | 1980 | 56152960 |
Incorrect route of product administration | 13.11 | 9.96 | 93 | 137034 | 21236 | 56133704 |
Basal cell carcinoma | 13.08 | 9.96 | 26 | 137101 | 25195 | 56129745 |
Shock haemorrhagic | 13.03 | 9.96 | 3 | 137124 | 9030 | 56145910 |
Brain stem syndrome | 13.02 | 9.96 | 9 | 137118 | 343 | 56154597 |
Coagulopathy | 12.84 | 9.96 | 16 | 137111 | 18700 | 56136240 |
Drug reaction with eosinophilia and systemic symptoms | 12.71 | 9.96 | 35 | 137092 | 30269 | 56124671 |
Mental impairment | 12.69 | 9.96 | 63 | 137064 | 12659 | 56142281 |
Bipolar I disorder | 12.67 | 9.96 | 18 | 137109 | 1672 | 56153268 |
Bronchiectasis | 12.64 | 9.96 | 6 | 137121 | 11428 | 56143512 |
Food craving | 12.62 | 9.96 | 17 | 137110 | 1502 | 56153438 |
Stoma site ulcer | 12.62 | 9.96 | 8 | 137119 | 263 | 56154677 |
Blood pressure fluctuation | 12.58 | 9.96 | 53 | 137074 | 40307 | 56114633 |
Anaphylactic shock | 12.54 | 9.96 | 21 | 137106 | 21719 | 56133221 |
Executive dysfunction | 12.51 | 9.96 | 7 | 137120 | 182 | 56154758 |
Diverticulitis | 12.50 | 9.96 | 45 | 137082 | 35807 | 56119133 |
Flat affect | 12.49 | 9.96 | 16 | 137111 | 1346 | 56153594 |
Depressive symptom | 12.44 | 9.96 | 27 | 137100 | 3514 | 56151426 |
Bezoar | 12.44 | 9.96 | 16 | 137111 | 1352 | 56153588 |
Carbon monoxide poisoning | 12.41 | 9.96 | 7 | 137120 | 185 | 56154755 |
Device expulsion | 12.40 | 9.96 | 121 | 137006 | 30328 | 56124612 |
Hypoaesthesia | 12.39 | 9.96 | 441 | 136686 | 141050 | 56013890 |
Therapeutic product effect decreased | 12.39 | 9.96 | 316 | 136811 | 169136 | 55985804 |
Personality disorder | 12.35 | 9.96 | 34 | 137093 | 5139 | 56149801 |
Yawning | 12.32 | 9.96 | 14 | 137113 | 1039 | 56153901 |
Right ventricular failure | 12.32 | 9.96 | 13 | 137114 | 16366 | 56138574 |
Parkinsonism | 12.31 | 9.96 | 51 | 137076 | 9495 | 56145445 |
Insurance issue | 12.29 | 9.96 | 28 | 137099 | 3764 | 56151176 |
Haemophagocytic lymphohistiocytosis | 12.27 | 9.96 | 4 | 137123 | 9568 | 56145372 |
Muscle rigidity | 12.22 | 9.96 | 55 | 137072 | 10616 | 56144324 |
Pain in jaw | 12.21 | 9.96 | 53 | 137074 | 39983 | 56114957 |
Pancreatitis acute | 12.11 | 9.96 | 27 | 137100 | 25097 | 56129843 |
Orthostatic hypotension | 12.03 | 9.96 | 41 | 137086 | 33158 | 56121782 |
Injection site mass | 11.99 | 9.96 | 76 | 137051 | 16717 | 56138223 |
Haematoma | 11.97 | 9.96 | 39 | 137088 | 31980 | 56122960 |
Drug ineffective | 11.96 | 9.96 | 2013 | 135114 | 916976 | 55237964 |
Embedded device | 11.89 | 9.96 | 24 | 137103 | 2969 | 56151971 |
Road traffic accident | 11.88 | 9.96 | 112 | 137015 | 27815 | 56127125 |
Arthritis | 11.87 | 9.96 | 323 | 136804 | 99529 | 56055411 |
Device related infection | 11.84 | 9.96 | 22 | 137105 | 21858 | 56133082 |
Tooth fracture | 11.79 | 9.96 | 53 | 137074 | 10223 | 56144717 |
Galactorrhoea | 11.79 | 9.96 | 28 | 137099 | 3867 | 56151073 |
Social anxiety disorder | 11.79 | 9.96 | 9 | 137118 | 401 | 56154539 |
Blood pressure orthostatic abnormal | 11.78 | 9.96 | 3 | 137124 | 6 | 56154934 |
Pituitary hyperplasia | 11.78 | 9.96 | 3 | 137124 | 6 | 56154934 |
Metastases to lung | 11.71 | 9.96 | 7 | 137120 | 11711 | 56143229 |
Drug resistance | 11.70 | 9.96 | 20 | 137107 | 20522 | 56134418 |
Hepatic encephalopathy | 11.66 | 9.96 | 5 | 137122 | 10105 | 56144835 |
Bone pain | 11.62 | 9.96 | 73 | 137054 | 50112 | 56104828 |
Ankle arthroplasty | 11.62 | 9.96 | 16 | 137111 | 1444 | 56153496 |
Fear | 11.61 | 9.96 | 69 | 137058 | 14839 | 56140101 |
Blood potassium increased | 11.59 | 9.96 | 15 | 137112 | 17246 | 56137694 |
Hypertension | 11.59 | 9.96 | 716 | 136411 | 243562 | 55911378 |
Pulmonary oedema | 11.53 | 9.96 | 75 | 137052 | 51068 | 56103872 |
Drug screen false positive | 11.51 | 9.96 | 12 | 137115 | 808 | 56154132 |
Suicidal behaviour | 11.49 | 9.96 | 21 | 137106 | 2412 | 56152528 |
Homeless | 11.48 | 9.96 | 5 | 137122 | 74 | 56154866 |
Bipolar II disorder | 11.45 | 9.96 | 8 | 137119 | 310 | 56154630 |
Distractibility | 11.44 | 9.96 | 9 | 137118 | 419 | 56154521 |
Disorientation | 11.43 | 9.96 | 138 | 136989 | 36475 | 56118465 |
Tri-iodothyronine free decreased | 11.43 | 9.96 | 8 | 137119 | 311 | 56154629 |
Rectal haemorrhage | 11.41 | 9.96 | 57 | 137070 | 41410 | 56113530 |
Bankruptcy | 11.37 | 9.96 | 4 | 137123 | 32 | 56154908 |
Inadequate analgesia | 11.31 | 9.96 | 22 | 137105 | 2649 | 56152291 |
Illusion | 11.27 | 9.96 | 13 | 137114 | 981 | 56153959 |
Electrocardiogram QRS complex shortened | 11.26 | 9.96 | 9 | 137118 | 429 | 56154511 |
Impulsive behaviour | 11.23 | 9.96 | 16 | 137111 | 1491 | 56153449 |
Panic disorder | 11.14 | 9.96 | 21 | 137106 | 2470 | 56152470 |
Priapism | 11.13 | 9.96 | 5 | 137122 | 80 | 56154860 |
Intermenstrual bleeding | 11.07 | 9.96 | 40 | 137087 | 6987 | 56147953 |
Partner stress | 11.04 | 9.96 | 8 | 137119 | 329 | 56154611 |
Panic reaction | 11.02 | 9.96 | 27 | 137100 | 3803 | 56151137 |
Injury | 11.02 | 9.96 | 206 | 136921 | 59645 | 56095295 |
Gaze palsy | 11.01 | 9.96 | 15 | 137112 | 1340 | 56153600 |
Essential tremor | 10.97 | 9.96 | 13 | 137114 | 1010 | 56153930 |
Diabetes mellitus | 10.95 | 9.96 | 185 | 136942 | 52550 | 56102390 |
Body temperature decreased | 10.90 | 9.96 | 17 | 137110 | 18091 | 56136849 |
Blood pressure diastolic decreased | 10.84 | 9.96 | 19 | 137108 | 19304 | 56135636 |
Haemolytic anaemia | 10.84 | 9.96 | 5 | 137122 | 9680 | 56145260 |
Nystagmus | 10.79 | 9.96 | 35 | 137092 | 5790 | 56149150 |
Convulsive threshold lowered | 10.79 | 9.96 | 8 | 137119 | 341 | 56154599 |
Vocal cord thickening | 10.77 | 9.96 | 4 | 137123 | 38 | 56154902 |
Middle insomnia | 10.76 | 9.96 | 54 | 137073 | 10896 | 56144044 |
Acute myocardial infarction | 10.70 | 9.96 | 38 | 137089 | 30355 | 56124585 |
Serum sickness-like reaction | 10.67 | 9.96 | 9 | 137118 | 463 | 56154477 |
Poor quality sleep | 10.67 | 9.96 | 77 | 137050 | 17678 | 56137262 |
Tubulointerstitial nephritis | 10.66 | 9.96 | 15 | 137112 | 16650 | 56138290 |
Pulmonary toxicity | 10.64 | 9.96 | 3 | 137124 | 7880 | 56147060 |
Abnormal sleep-related event | 10.62 | 9.96 | 11 | 137116 | 735 | 56154205 |
Concussion | 10.59 | 9.96 | 44 | 137083 | 8202 | 56146738 |
Postmortem blood drug level abnormal | 10.58 | 9.96 | 8 | 137119 | 351 | 56154589 |
Poor feeding infant | 10.55 | 9.96 | 7 | 137120 | 249 | 56154691 |
Hyperphagia | 10.52 | 9.96 | 16 | 137111 | 1580 | 56153360 |
Ankle operation | 10.51 | 9.96 | 14 | 137113 | 1224 | 56153716 |
Mouth ulceration | 10.47 | 9.96 | 37 | 137090 | 29603 | 56125337 |
Foetal death | 10.39 | 9.96 | 45 | 137082 | 8542 | 56146398 |
Gait disturbance | 10.39 | 9.96 | 492 | 136635 | 162829 | 55992111 |
Hangover | 10.36 | 9.96 | 15 | 137112 | 1418 | 56153522 |
Cystitis interstitial | 10.35 | 9.96 | 15 | 137112 | 1419 | 56153521 |
Live birth | 10.35 | 9.96 | 20 | 137107 | 19585 | 56135355 |
Haemodialysis | 10.31 | 9.96 | 4 | 137123 | 8587 | 56146353 |
Rhinorrhoea | 10.31 | 9.96 | 89 | 137038 | 56948 | 56097992 |
Red blood cell count decreased | 10.26 | 9.96 | 50 | 137077 | 36567 | 56118373 |
Tearfulness | 10.25 | 9.96 | 26 | 137101 | 3742 | 56151198 |
Osteoporosis | 10.23 | 9.96 | 181 | 136946 | 51871 | 56103069 |
Haemoptysis | 10.18 | 9.96 | 32 | 137095 | 26528 | 56128412 |
Blood pressure diastolic abnormal | 10.16 | 9.96 | 8 | 137119 | 11590 | 56143350 |
Eosinophilia | 10.16 | 9.96 | 21 | 137106 | 20056 | 56134884 |
Foot operation | 10.15 | 9.96 | 36 | 137091 | 6231 | 56148709 |
Heavy menstrual bleeding | 10.15 | 9.96 | 71 | 137056 | 16138 | 56138802 |
Accidental poisoning | 10.11 | 9.96 | 10 | 137117 | 633 | 56154307 |
Bacteraemia | 10.07 | 9.96 | 14 | 137113 | 15617 | 56139323 |
Pineal gland cyst | 10.07 | 9.96 | 3 | 137124 | 13 | 56154927 |
Clostridium difficile colitis | 10.00 | 9.96 | 19 | 137108 | 18719 | 56136221 |
MedDRA adverse event term | Likelihood ratio | Likelihood ratio threshold | Patients taking drug having adverse event | Patients taking drug not having adverse event | Patients not taking drug having adverse event | Patients not taking drug not having adverse event |
---|---|---|---|---|---|---|
Completed suicide | 2175.39 | 11.39 | 1535 | 51471 | 89979 | 31554359 |
Depression | 1529.10 | 11.39 | 1241 | 51765 | 89574 | 31554764 |
Toxicity to various agents | 600.15 | 11.39 | 1080 | 51926 | 180407 | 31463931 |
Drug interaction | 536.47 | 11.39 | 1116 | 51890 | 207427 | 31436911 |
Serotonin syndrome | 507.08 | 11.39 | 342 | 52664 | 18431 | 31625907 |
Suicidal ideation | 361.30 | 11.39 | 371 | 52635 | 36035 | 31608303 |
Intentional overdose | 356.22 | 11.39 | 391 | 52615 | 40998 | 31603340 |
Overdose | 309.97 | 11.39 | 528 | 52478 | 84136 | 31560202 |
Anxiety | 308.93 | 11.39 | 549 | 52457 | 90484 | 31553854 |
Drug abuse | 241.40 | 11.39 | 484 | 52522 | 87274 | 31557064 |
Seizure | 225.58 | 11.39 | 508 | 52498 | 99260 | 31545078 |
Loss of personal independence in daily activities | 200.69 | 11.39 | 242 | 52764 | 28046 | 31616292 |
Cardio-respiratory arrest | 188.27 | 11.39 | 322 | 52684 | 51404 | 31592934 |
Psychiatric decompensation | 187.92 | 11.39 | 83 | 52923 | 1893 | 31642445 |
Febrile neutropenia | 149.97 | 11.39 | 15 | 52991 | 121834 | 31522504 |
Depression suicidal | 149.90 | 11.39 | 67 | 52939 | 1573 | 31642765 |
Suicide attempt | 143.62 | 11.39 | 238 | 52768 | 37010 | 31607328 |
Electrocardiogram QRS complex prolonged | 143.53 | 11.39 | 89 | 52917 | 4140 | 31640198 |
Status epilepticus | 137.73 | 11.39 | 133 | 52873 | 11973 | 31632365 |
Generalised tonic-clonic seizure | 137.24 | 11.39 | 168 | 52838 | 19763 | 31624575 |
Paranoia | 133.55 | 11.39 | 123 | 52883 | 10432 | 31633906 |
Tearfulness | 133.54 | 11.39 | 65 | 52941 | 1862 | 31642476 |
Hyperreflexia | 131.40 | 11.39 | 74 | 52932 | 2875 | 31641463 |
Anaemia | 129.14 | 11.39 | 101 | 52905 | 213421 | 31430917 |
Acute kidney injury | 123.50 | 11.39 | 173 | 52833 | 279541 | 31364797 |
Thrombocytopenia | 120.66 | 11.39 | 44 | 52962 | 142703 | 31501635 |
Psychotic disorder | 106.15 | 11.39 | 157 | 52849 | 22136 | 31622202 |
Tremor | 105.58 | 11.39 | 324 | 52682 | 76096 | 31568242 |
Poisoning | 104.95 | 11.39 | 107 | 52899 | 10284 | 31634054 |
Suspected suicide | 97.10 | 11.39 | 69 | 52937 | 4038 | 31640300 |
Distributive shock | 94.19 | 11.39 | 43 | 52963 | 1062 | 31643276 |
Depressive symptom | 94.06 | 11.39 | 53 | 52953 | 2061 | 31642277 |
Insomnia | 89.21 | 11.39 | 354 | 52652 | 94482 | 31549856 |
Sepsis | 87.86 | 11.39 | 75 | 52931 | 151854 | 31492484 |
Pyrexia | 87.27 | 11.39 | 242 | 52764 | 303598 | 31340740 |
Agitation | 86.60 | 11.39 | 242 | 52764 | 53927 | 31590411 |
Sexual dysfunction | 82.28 | 11.39 | 73 | 52933 | 5895 | 31638443 |
Neutropenia | 81.51 | 11.39 | 69 | 52937 | 140295 | 31504043 |
Malignant neoplasm progression | 76.38 | 11.39 | 19 | 52987 | 78979 | 31565359 |
Product substitution issue | 75.68 | 11.39 | 86 | 52920 | 9346 | 31634992 |
Major depression | 75.09 | 11.39 | 60 | 52946 | 4193 | 31640145 |
General physical health deterioration | 74.55 | 11.39 | 49 | 52957 | 113386 | 31530952 |
Pneumonia | 71.24 | 11.39 | 304 | 52702 | 335008 | 31309330 |
Psychomotor skills impaired | 70.41 | 11.39 | 51 | 52955 | 3076 | 31641262 |
Pancytopenia | 67.10 | 11.39 | 31 | 52975 | 87285 | 31557053 |
Platelet count decreased | 66.94 | 11.39 | 52 | 52954 | 110383 | 31533955 |
Postmortem blood drug level increased | 66.14 | 11.39 | 22 | 52984 | 222 | 31644116 |
Depressed mood | 64.63 | 11.39 | 110 | 52896 | 17465 | 31626873 |
Interstitial lung disease | 62.89 | 11.39 | 13 | 52993 | 61390 | 31582948 |
Rhinitis perennial | 59.77 | 11.39 | 22 | 52984 | 306 | 31644032 |
Panic attack | 59.31 | 11.39 | 73 | 52933 | 8630 | 31635708 |
Therapeutic response unexpected | 58.78 | 11.39 | 74 | 52932 | 8950 | 31635388 |
Septic shock | 58.24 | 11.39 | 19 | 52987 | 66139 | 31578199 |
Irritability | 57.76 | 11.39 | 122 | 52884 | 22767 | 31621571 |
Exposure via ingestion | 57.28 | 11.39 | 38 | 52968 | 1987 | 31642351 |
Respiratory arrest | 57.27 | 11.39 | 132 | 52874 | 26125 | 31618213 |
Hyperkalaemia | 55.74 | 11.39 | 19 | 52987 | 64332 | 31580006 |
Renal impairment | 54.45 | 11.39 | 39 | 52967 | 86310 | 31558028 |
Cardiogenic shock | 53.75 | 11.39 | 117 | 52889 | 22291 | 31622047 |
Anger | 53.73 | 11.39 | 79 | 52927 | 11074 | 31633264 |
Disturbance in attention | 53.60 | 11.39 | 117 | 52889 | 22333 | 31622005 |
Tardive dyskinesia | 52.09 | 11.39 | 55 | 52951 | 5504 | 31638834 |
Clonus | 52.02 | 11.39 | 39 | 52967 | 2480 | 31641858 |
Memory impairment | 51.98 | 11.39 | 161 | 52845 | 37969 | 31606369 |
Vein of Galen aneurysmal malformation | 51.74 | 11.39 | 11 | 52995 | 11 | 31644327 |
C-reactive protein increased | 50.44 | 11.39 | 10 | 52996 | 48640 | 31595698 |
Disease progression | 49.44 | 11.39 | 47 | 52959 | 90417 | 31553921 |
Feeling abnormal | 48.96 | 11.39 | 207 | 52799 | 56795 | 31587543 |
Cardiac failure | 48.94 | 11.39 | 43 | 52963 | 85910 | 31558428 |
Pupil fixed | 48.20 | 11.39 | 32 | 52974 | 1675 | 31642663 |
Diarrhoea | 48.03 | 11.39 | 369 | 52637 | 352040 | 31292298 |
Erectile dysfunction | 47.93 | 11.39 | 102 | 52904 | 19133 | 31625205 |
Dyspnoea | 47.10 | 11.39 | 359 | 52647 | 343120 | 31301218 |
Autonomic nervous system imbalance | 46.12 | 11.39 | 36 | 52970 | 2431 | 31641907 |
Incorrect route of product administration | 45.50 | 11.39 | 75 | 52931 | 11598 | 31632740 |
Electrocardiogram QT prolonged | 44.21 | 11.39 | 152 | 52854 | 37835 | 31606503 |
Drug withdrawal syndrome | 43.94 | 11.39 | 97 | 52909 | 18653 | 31625685 |
Libido decreased | 43.56 | 11.39 | 45 | 52961 | 4391 | 31639947 |
Renal failure | 43.42 | 11.39 | 88 | 52918 | 123242 | 31521096 |
Cardiac arrest | 43.35 | 11.39 | 276 | 52730 | 88786 | 31555552 |
Haemoglobin decreased | 41.74 | 11.39 | 78 | 52928 | 112597 | 31531741 |
Adjustment disorder | 41.09 | 11.39 | 25 | 52981 | 1123 | 31643215 |
Sedation | 40.98 | 11.39 | 95 | 52911 | 18870 | 31625468 |
Maternal drugs affecting foetus | 40.88 | 11.39 | 41 | 52965 | 3862 | 31640476 |
Pleural effusion | 40.84 | 11.39 | 39 | 52967 | 74881 | 31569457 |
Myoclonus | 40.56 | 11.39 | 79 | 52927 | 13911 | 31630427 |
Product residue present | 39.94 | 11.39 | 34 | 52972 | 2596 | 31641742 |
Euphoric mood | 39.70 | 11.39 | 45 | 52961 | 4875 | 31639463 |
Hallucination, visual | 39.63 | 11.39 | 84 | 52922 | 15710 | 31628628 |
Off label use | 39.10 | 11.39 | 382 | 52624 | 346892 | 31297446 |
Multiple organ dysfunction syndrome | 38.96 | 11.39 | 34 | 52972 | 68169 | 31576169 |
Depersonalisation/derealisation disorder | 38.31 | 11.39 | 19 | 52987 | 567 | 31643771 |
Mucosal inflammation | 38.03 | 11.39 | 6 | 53000 | 34421 | 31609917 |
Psychomotor retardation | 37.49 | 11.39 | 36 | 52970 | 3216 | 31641122 |
Basilar artery occlusion | 36.98 | 11.39 | 11 | 52995 | 74 | 31644264 |
Hyponatraemic coma | 36.91 | 11.39 | 9 | 52997 | 24 | 31644314 |
Electrocardiogram PR prolongation | 36.74 | 11.39 | 20 | 52986 | 726 | 31643612 |
Intentional product misuse | 36.69 | 11.39 | 143 | 52863 | 37808 | 31606530 |
Neonatal toxicity | 36.13 | 11.39 | 9 | 52997 | 27 | 31644311 |
Drug reaction with eosinophilia and systemic symptoms | 36.10 | 11.39 | 4 | 53002 | 30014 | 31614324 |
Bradyphrenia | 35.06 | 11.39 | 40 | 52966 | 4364 | 31639974 |
Dysphoria | 34.89 | 11.39 | 29 | 52977 | 2143 | 31642195 |
Blood creatinine increased | 34.48 | 11.39 | 60 | 52946 | 89018 | 31555320 |
Lower respiratory tract infection | 33.36 | 11.39 | 4 | 53002 | 28233 | 31616105 |
Hypokalaemia | 32.72 | 11.39 | 25 | 52981 | 53549 | 31590789 |
Ascites | 32.37 | 11.39 | 14 | 52992 | 40999 | 31603339 |
Rheumatoid arthritis | 32.27 | 11.39 | 20 | 52986 | 47789 | 31596549 |
Mood swings | 32.09 | 11.39 | 50 | 52956 | 7374 | 31636964 |
Substance abuse | 32.04 | 11.39 | 49 | 52957 | 7109 | 31637229 |
Mania | 31.85 | 11.39 | 56 | 52950 | 9121 | 31635217 |
Mood altered | 31.69 | 11.39 | 53 | 52953 | 8293 | 31636045 |
Leukopenia | 31.63 | 11.39 | 30 | 52976 | 57798 | 31586540 |
Infection | 30.97 | 11.39 | 56 | 52950 | 81875 | 31562463 |
Tinnitus | 30.32 | 11.39 | 77 | 52929 | 16198 | 31628140 |
Transposition of the great vessels | 30.17 | 11.39 | 15 | 52991 | 450 | 31643888 |
Vasoplegia syndrome | 29.88 | 11.39 | 24 | 52982 | 1689 | 31642649 |
Melaena | 29.40 | 11.39 | 9 | 52997 | 32645 | 31611693 |
Aggression | 29.39 | 11.39 | 132 | 52874 | 37159 | 31607179 |
Restless legs syndrome | 29.11 | 11.39 | 49 | 52957 | 7707 | 31636631 |
Intentional self-injury | 29.09 | 11.39 | 67 | 52939 | 13248 | 31631090 |
Encephalopathy neonatal | 28.73 | 11.39 | 8 | 52998 | 41 | 31644297 |
White blood cell count decreased | 28.55 | 11.39 | 65 | 52941 | 87333 | 31557005 |
Cholestasis | 28.55 | 11.39 | 4 | 53002 | 25071 | 31619267 |
Talipes | 28.31 | 11.39 | 24 | 52982 | 1822 | 31642516 |
Hepatic function abnormal | 28.16 | 11.39 | 17 | 52989 | 41205 | 31603133 |
Cytomegalovirus infection | 27.99 | 11.39 | 4 | 53002 | 24703 | 31619635 |
Feelings of worthlessness | 27.48 | 11.39 | 12 | 52994 | 266 | 31644072 |
Hallucination | 27.17 | 11.39 | 151 | 52855 | 46259 | 31598079 |
Delusion | 26.91 | 11.39 | 61 | 52945 | 11936 | 31632402 |
Prescribed overdose | 26.76 | 11.39 | 52 | 52954 | 9140 | 31635198 |
Drug withdrawal syndrome neonatal | 26.60 | 11.39 | 31 | 52975 | 3461 | 31640877 |
Tachycardia | 26.55 | 11.39 | 218 | 52788 | 75989 | 31568349 |
Gastrointestinal haemorrhage | 26.47 | 11.39 | 62 | 52944 | 82487 | 31561851 |
Feeling jittery | 26.25 | 11.39 | 32 | 52974 | 3745 | 31640593 |
Infusion related reaction | 26.20 | 11.39 | 25 | 52981 | 48030 | 31596308 |
Crying | 26.03 | 11.39 | 39 | 52967 | 5558 | 31638780 |
Eosinophilia | 25.80 | 11.39 | 4 | 53002 | 23249 | 31621089 |
Erythema | 25.30 | 11.39 | 61 | 52945 | 80344 | 31563994 |
Dry mouth | 25.15 | 11.39 | 94 | 52912 | 24364 | 31619974 |
Abnormal behaviour | 24.85 | 11.39 | 92 | 52914 | 23736 | 31620602 |
Emotional distress | 24.77 | 11.39 | 66 | 52940 | 14290 | 31630048 |
Abdominal pain | 24.72 | 11.39 | 143 | 52863 | 145809 | 31498529 |
Bone marrow failure | 24.71 | 11.39 | 8 | 52998 | 28000 | 31616338 |
Cerebral haemorrhage | 24.65 | 11.39 | 12 | 52994 | 32800 | 31611538 |
Apathy | 24.39 | 11.39 | 41 | 52965 | 6441 | 31637897 |
Drug dependence | 24.24 | 11.39 | 88 | 52918 | 22491 | 31621847 |
Mental status changes | 23.76 | 11.39 | 121 | 52885 | 35847 | 31608491 |
Sleep disorder | 23.63 | 11.39 | 97 | 52909 | 26251 | 31618087 |
Malaise | 23.53 | 11.39 | 175 | 52831 | 168336 | 31476002 |
Atrial fibrillation | 23.52 | 11.39 | 104 | 52902 | 113679 | 31530659 |
Withdrawal syndrome | 23.47 | 11.39 | 57 | 52949 | 11660 | 31632678 |
Thinking abnormal | 23.34 | 11.39 | 37 | 52969 | 5536 | 31638802 |
Stomatitis | 23.33 | 11.39 | 19 | 52987 | 39419 | 31604919 |
Pelvic abscess | 23.25 | 11.39 | 16 | 52990 | 889 | 31643449 |
Dehydration | 22.77 | 11.39 | 112 | 52894 | 118999 | 31525339 |
Gamma-glutamyltransferase increased | 22.76 | 11.39 | 9 | 52997 | 27816 | 31616522 |
Hypomania | 22.53 | 11.39 | 23 | 52983 | 2212 | 31642126 |
Hallucination, auditory | 22.49 | 11.39 | 52 | 52954 | 10308 | 31634030 |
Oedema peripheral | 22.34 | 11.39 | 101 | 52905 | 109738 | 31534600 |
Dissociation | 22.08 | 11.39 | 18 | 52988 | 1294 | 31643044 |
Respiratory failure | 22.03 | 11.39 | 91 | 52915 | 101358 | 31542980 |
Marital problem | 21.85 | 11.39 | 7 | 52999 | 62 | 31644276 |
Jaundice | 21.38 | 11.39 | 12 | 52994 | 30275 | 31614063 |
Dyskinesia | 21.20 | 11.39 | 80 | 52926 | 20830 | 31623508 |
Decreased interest | 21.15 | 11.39 | 22 | 52984 | 2163 | 31642175 |
Akathisia | 21.07 | 11.39 | 41 | 52965 | 7212 | 31637126 |
Oxygen saturation decreased | 20.95 | 11.39 | 31 | 52975 | 49084 | 31595254 |
Hallucination, tactile | 20.95 | 11.39 | 10 | 52996 | 274 | 31644064 |
Orgasm abnormal | 20.88 | 11.39 | 8 | 52998 | 125 | 31644213 |
Product complaint | 20.87 | 11.39 | 35 | 52971 | 5489 | 31638849 |
Unresponsive to stimuli | 20.83 | 11.39 | 92 | 52914 | 25708 | 31618630 |
Weight increased | 20.71 | 11.39 | 221 | 52785 | 82726 | 31561612 |
Gun shot wound | 20.53 | 11.39 | 16 | 52990 | 1078 | 31643260 |
Substance use disorder | 20.39 | 11.39 | 12 | 52994 | 507 | 31643831 |
Road traffic accident | 20.33 | 11.39 | 67 | 52939 | 16314 | 31628024 |
Nightmare | 20.14 | 11.39 | 55 | 52951 | 12082 | 31632256 |
Amnesia | 20.09 | 11.39 | 85 | 52921 | 23317 | 31621021 |
Prostate cancer | 19.99 | 11.39 | 20 | 52986 | 37581 | 31606757 |
Persecutory delusion | 19.81 | 11.39 | 22 | 52984 | 2330 | 31642008 |
Vomiting | 19.76 | 11.39 | 260 | 52746 | 223713 | 31420625 |
Disseminated intravascular coagulation | 19.72 | 11.39 | 5 | 53001 | 20532 | 31623806 |
Pre-existing condition improved | 19.62 | 11.39 | 22 | 52984 | 2355 | 31641983 |
Dysarthria | 19.29 | 11.39 | 105 | 52901 | 31912 | 31612426 |
Ideas of reference | 19.27 | 11.39 | 6 | 53000 | 48 | 31644290 |
Liver disorder | 19.26 | 11.39 | 13 | 52993 | 29694 | 31614644 |
Haematuria | 19.02 | 11.39 | 30 | 52976 | 46284 | 31598054 |
Lupus-like syndrome | 18.75 | 11.39 | 22 | 52984 | 2473 | 31641865 |
Atrial septal defect | 18.73 | 11.39 | 38 | 52968 | 6889 | 31637449 |
Disorientation | 18.64 | 11.39 | 101 | 52905 | 30643 | 31613695 |
Lung disorder | 18.58 | 11.39 | 16 | 52990 | 32296 | 31612042 |
Injection site reaction | 18.54 | 11.39 | 52 | 52954 | 11599 | 31632739 |
Drug resistance | 18.51 | 11.39 | 8 | 52998 | 23445 | 31620893 |
Plasma cell myeloma | 18.49 | 11.39 | 42 | 52964 | 56489 | 31587849 |
Obsessive-compulsive disorder | 18.28 | 11.39 | 31 | 52975 | 4906 | 31639432 |
Toxic epidermal necrolysis | 18.27 | 11.39 | 5 | 53001 | 19519 | 31624819 |
Foetal exposure during pregnancy | 18.24 | 11.39 | 124 | 52882 | 40752 | 31603586 |
Clonic convulsion | 18.14 | 11.39 | 12 | 52994 | 624 | 31643714 |
Obesity | 18.12 | 11.39 | 50 | 52956 | 11050 | 31633288 |
Psychomotor hyperactivity | 17.87 | 11.39 | 43 | 52963 | 8744 | 31635594 |
Alcoholism | 17.72 | 11.39 | 25 | 52981 | 3374 | 31640964 |
Hepatocellular injury | 17.57 | 11.39 | 7 | 52999 | 21537 | 31622801 |
Abulia | 17.44 | 11.39 | 11 | 52995 | 527 | 31643811 |
Blood testosterone decreased | 17.39 | 11.39 | 28 | 52978 | 4245 | 31640093 |
Agranulocytosis | 17.17 | 11.39 | 7 | 52999 | 21240 | 31623098 |
Acute myeloid leukaemia | 17.07 | 11.39 | 5 | 53001 | 18667 | 31625671 |
International normalised ratio increased | 17.00 | 11.39 | 31 | 52975 | 45192 | 31599146 |
Accidental poisoning | 16.63 | 11.39 | 12 | 52994 | 719 | 31643619 |
Mydriasis | 16.61 | 11.39 | 35 | 52971 | 6517 | 31637821 |
Cognitive disorder | 16.57 | 11.39 | 84 | 52922 | 24839 | 31619499 |
Gastrooesophageal reflux disease | 16.47 | 11.39 | 105 | 52901 | 33766 | 31610572 |
Postictal state | 16.44 | 11.39 | 12 | 52994 | 732 | 31643606 |
Delirium | 16.35 | 11.39 | 122 | 52884 | 41299 | 31603039 |
Dependence | 16.32 | 11.39 | 14 | 52992 | 1080 | 31643258 |
Cutaneous lupus erythematosus | 16.30 | 11.39 | 12 | 52994 | 742 | 31643596 |
Vision blurred | 16.29 | 11.39 | 123 | 52883 | 41792 | 31602546 |
Dissociative disorder | 16.22 | 11.39 | 8 | 52998 | 236 | 31644102 |
Poor feeding infant | 16.14 | 11.39 | 10 | 52996 | 464 | 31643874 |
Myelodysplastic syndrome | 16.12 | 11.39 | 6 | 53000 | 19245 | 31625093 |
Loss of employment | 15.88 | 11.39 | 10 | 52996 | 478 | 31643860 |
Product quality issue | 15.80 | 11.39 | 61 | 52945 | 16050 | 31628288 |
Decreased appetite | 15.74 | 11.39 | 172 | 52834 | 153045 | 31491293 |
Tongue biting | 15.73 | 11.39 | 12 | 52994 | 783 | 31643555 |
Hallucinations, mixed | 15.54 | 11.39 | 20 | 52986 | 2472 | 31641866 |
Hostility | 15.44 | 11.39 | 12 | 52994 | 805 | 31643533 |
Gastric hypomotility | 15.31 | 11.39 | 6 | 53000 | 100 | 31644238 |
Treatment failure | 15.30 | 11.39 | 28 | 52978 | 40764 | 31603574 |
Upper gastrointestinal haemorrhage | 15.23 | 11.39 | 10 | 52996 | 23173 | 31621165 |
Hyperhidrosis | 15.19 | 11.39 | 176 | 52830 | 67217 | 31577121 |
Inflammation | 15.13 | 11.39 | 12 | 52994 | 25229 | 31619109 |
Energy increased | 15.05 | 11.39 | 14 | 52992 | 1202 | 31643136 |
Hypoglycaemia | 14.97 | 11.39 | 40 | 52966 | 50906 | 31593432 |
Suicidal behaviour | 14.92 | 11.39 | 15 | 52991 | 1417 | 31642921 |
Abnormal clotting factor | 14.90 | 11.39 | 5 | 53001 | 52 | 31644286 |
Colitis | 14.83 | 11.39 | 21 | 52985 | 33866 | 31610472 |
Hypoplastic right heart syndrome | 14.79 | 11.39 | 4 | 53002 | 18 | 31644320 |
Neutrophil count decreased | 14.74 | 11.39 | 35 | 52971 | 46359 | 31597979 |
Balance disorder | 14.65 | 11.39 | 110 | 52896 | 37312 | 31607026 |
Hunger | 14.62 | 11.39 | 15 | 52991 | 1452 | 31642886 |
Loss of libido | 14.59 | 11.39 | 19 | 52987 | 2376 | 31641962 |
Hepatic failure | 14.58 | 11.39 | 20 | 52986 | 32682 | 31611656 |
Brugada syndrome | 14.57 | 11.39 | 11 | 52995 | 707 | 31643631 |
Priapism | 14.51 | 11.39 | 27 | 52979 | 4593 | 31639745 |
Injection site mass | 14.49 | 11.39 | 31 | 52975 | 5833 | 31638505 |
Rash maculo-papular | 14.46 | 11.39 | 13 | 52993 | 25706 | 31618632 |
Persistent depressive disorder | 14.39 | 11.39 | 8 | 52998 | 303 | 31644035 |
Pulmonary fibrosis | 14.28 | 11.39 | 5 | 53001 | 16655 | 31627683 |
Blood triglycerides increased | 14.20 | 11.39 | 52 | 52954 | 13345 | 31630993 |
Lip pruritus | 14.11 | 11.39 | 3 | 53003 | 3 | 31644335 |
Binge drinking | 14.11 | 11.39 | 3 | 53003 | 3 | 31644335 |
Urine amphetamine positive | 13.98 | 11.39 | 4 | 53002 | 23 | 31644315 |
Sleep apnoea syndrome | 13.98 | 11.39 | 65 | 52941 | 18560 | 31625778 |
Sinus tachycardia | 13.94 | 11.39 | 58 | 52948 | 15791 | 31628547 |
Double inlet left ventricle | 13.84 | 11.39 | 4 | 53002 | 24 | 31644314 |
Pulmonary oedema | 13.80 | 11.39 | 34 | 52972 | 44468 | 31599870 |
Sleep disorder due to a general medical condition | 13.79 | 11.39 | 24 | 52982 | 3878 | 31640460 |
Lactic acidosis | 13.77 | 11.39 | 20 | 52986 | 31917 | 31612421 |
Abnormal dreams | 13.62 | 11.39 | 34 | 52972 | 7074 | 31637264 |
Product solubility abnormal | 13.54 | 11.39 | 9 | 52997 | 472 | 31643866 |
Toxic optic neuropathy | 13.54 | 11.39 | 11 | 52995 | 787 | 31643551 |
Tubulointerstitial nephritis | 13.54 | 11.39 | 7 | 52999 | 18489 | 31625849 |
Gambling disorder | 13.52 | 11.39 | 15 | 52991 | 1587 | 31642751 |
Extra dose administered | 13.46 | 11.39 | 22 | 52984 | 3378 | 31640960 |
Ejaculation disorder | 13.43 | 11.39 | 12 | 52994 | 978 | 31643360 |
Neuropathy peripheral | 13.40 | 11.39 | 73 | 52933 | 75576 | 31568762 |
Migraine | 13.35 | 11.39 | 53 | 52953 | 14127 | 31630211 |
Bipolar disorder | 13.28 | 11.39 | 23 | 52983 | 3701 | 31640637 |
Mental disorder | 13.26 | 11.39 | 52 | 52954 | 13782 | 31630556 |
Depressed level of consciousness | 13.20 | 11.39 | 110 | 52896 | 38491 | 31605847 |
Testicular pain | 13.19 | 11.39 | 19 | 52987 | 2613 | 31641725 |
Sperm concentration decreased | 13.11 | 11.39 | 6 | 53000 | 149 | 31644189 |
Haemoptysis | 13.07 | 11.39 | 21 | 52985 | 32168 | 31612170 |
Ventricular hypoplasia | 13.06 | 11.39 | 5 | 53001 | 78 | 31644260 |
Epistaxis | 13.05 | 11.39 | 46 | 52960 | 53661 | 31590677 |
Blood lactate dehydrogenase increased | 13.05 | 11.39 | 9 | 52997 | 20330 | 31624008 |
Pericardial effusion | 13.01 | 11.39 | 11 | 52995 | 22412 | 31621926 |
Inadequate analgesia | 12.86 | 11.39 | 19 | 52987 | 2674 | 31641664 |
Enuresis | 12.80 | 11.39 | 17 | 52989 | 2167 | 31642171 |
Slow speech | 12.78 | 11.39 | 12 | 52994 | 1042 | 31643296 |
Muscle rigidity | 12.75 | 11.39 | 41 | 52965 | 9856 | 31634482 |
Lymphadenopathy | 12.66 | 11.39 | 15 | 52991 | 26106 | 31618232 |
Lethargy | 12.63 | 11.39 | 109 | 52897 | 38532 | 31605806 |
Cytokine release syndrome | 12.63 | 11.39 | 6 | 53000 | 16636 | 31627702 |
Respiratory distress | 12.61 | 11.39 | 23 | 52983 | 33530 | 31610808 |
Pneumonitis | 12.44 | 11.39 | 20 | 52986 | 30632 | 31613706 |
Univentricular heart | 12.43 | 11.39 | 4 | 53002 | 36 | 31644302 |
Bacteraemia | 12.43 | 11.39 | 7 | 52999 | 17627 | 31626711 |
Metastases to liver | 12.41 | 11.39 | 3 | 53003 | 12724 | 31631614 |
Muscle twitching | 12.38 | 11.39 | 36 | 52970 | 8194 | 31636144 |
Congenital aortic stenosis | 12.35 | 11.39 | 5 | 53001 | 91 | 31644247 |
Hypotonia neonatal | 12.35 | 11.39 | 13 | 52993 | 1296 | 31643042 |
Restlessness | 12.35 | 11.39 | 74 | 52932 | 23287 | 31621051 |
Pulmonary embolism | 12.25 | 11.39 | 83 | 52923 | 81563 | 31562775 |
Joint swelling | 12.17 | 11.39 | 47 | 52959 | 53384 | 31590954 |
Alanine aminotransferase increased | 12.17 | 11.39 | 74 | 52932 | 74582 | 31569756 |
Emotional disorder | 12.12 | 11.39 | 27 | 52979 | 5222 | 31639116 |
Urinary tract infection | 12.11 | 11.39 | 77 | 52929 | 76792 | 31567546 |
Product use in unapproved indication | 11.99 | 11.39 | 107 | 52899 | 99064 | 31545274 |
Hypercholesterolaemia | 11.96 | 11.39 | 35 | 52971 | 7995 | 31636343 |
Derealisation | 11.95 | 11.39 | 9 | 52997 | 576 | 31643762 |
Symptom masked | 11.91 | 11.39 | 9 | 52997 | 579 | 31643759 |
Haemorrhage | 11.87 | 11.39 | 40 | 52966 | 47294 | 31597044 |
Change in sustained attention | 11.80 | 11.39 | 3 | 53003 | 10 | 31644328 |
Drug eruption | 11.74 | 11.39 | 8 | 52998 | 18179 | 31626159 |
Male orgasmic disorder | 11.70 | 11.39 | 5 | 53001 | 105 | 31644233 |
Bladder cancer | 11.66 | 11.39 | 5 | 53001 | 14720 | 31629618 |
Tongue spasm | 11.63 | 11.39 | 4 | 53002 | 45 | 31644293 |
Accidental overdose | 11.61 | 11.39 | 61 | 52945 | 18289 | 31626049 |
Congenital tricuspid valve atresia | 11.57 | 11.39 | 5 | 53001 | 108 | 31644230 |
Gastric ulcer | 11.54 | 11.39 | 5 | 53001 | 14629 | 31629709 |
Hypomagnesaemia | 11.50 | 11.39 | 9 | 52997 | 19049 | 31625289 |
Drug screen positive | 11.47 | 11.39 | 22 | 52984 | 3830 | 31640508 |
MedDRA adverse event term | Likelihood ratio | Likelihood ratio threshold | Patients taking drug having adverse event | Patients taking drug not having adverse event | Patients not taking drug having adverse event | Patients not taking drug not having adverse event |
---|---|---|---|---|---|---|
Completed suicide | 5505.01 | 10.33 | 4256 | 147801 | 222879 | 70553508 |
Toxicity to various agents | 1381.18 | 10.33 | 2725 | 149332 | 379447 | 70396940 |
Depression | 1284.29 | 10.33 | 1841 | 150216 | 197133 | 70579254 |
Intentional overdose | 1053.17 | 10.33 | 1173 | 150884 | 97262 | 70679125 |
Overdose | 762.04 | 10.33 | 1331 | 150726 | 168414 | 70607973 |
Serotonin syndrome | 740.29 | 10.33 | 658 | 151399 | 41456 | 70734931 |
Seizure | 633.01 | 10.33 | 1263 | 150794 | 176699 | 70599688 |
Electrocardiogram QRS complex prolonged | 616.58 | 10.33 | 336 | 151721 | 9470 | 70766917 |
Anxiety | 551.06 | 10.33 | 1358 | 150699 | 218972 | 70557415 |
Generalised tonic-clonic seizure | 528.89 | 10.33 | 544 | 151513 | 41117 | 70735270 |
Cardio-respiratory arrest | 525.42 | 10.33 | 845 | 151212 | 99832 | 70676555 |
Suicidal ideation | 492.46 | 10.33 | 674 | 151383 | 68922 | 70707465 |
Suspected suicide | 401.32 | 10.33 | 245 | 151812 | 8589 | 70767798 |
Status epilepticus | 373.95 | 10.33 | 354 | 151703 | 24172 | 70752215 |
Suicide attempt | 329.93 | 10.33 | 603 | 151454 | 78907 | 70697480 |
Acute kidney injury | 274.60 | 10.33 | 370 | 151687 | 474254 | 70302133 |
Anaemia | 273.62 | 10.33 | 277 | 151780 | 403146 | 70373241 |
Febrile neutropenia | 267.31 | 10.33 | 56 | 152001 | 204262 | 70572125 |
Drug abuse | 265.97 | 10.33 | 806 | 151251 | 146450 | 70629937 |
Cardiac arrest | 256.68 | 10.33 | 840 | 151217 | 158994 | 70617393 |
Thrombocytopenia | 251.38 | 10.33 | 99 | 151958 | 239011 | 70537376 |
Electrocardiogram QT prolonged | 249.01 | 10.33 | 552 | 151505 | 82965 | 70693422 |
Agitation | 246.26 | 10.33 | 588 | 151469 | 92787 | 70683600 |
Temperature regulation disorder | 240.47 | 10.33 | 138 | 151919 | 4306 | 70772081 |
Product substitution issue | 238.96 | 10.33 | 244 | 151813 | 18269 | 70758118 |
Poisoning | 225.23 | 10.33 | 260 | 151797 | 22362 | 70754025 |
Respiratory arrest | 219.85 | 10.33 | 406 | 151651 | 53527 | 70722860 |
Neutropenia | 214.53 | 10.33 | 144 | 151913 | 257012 | 70519375 |
Pyrexia | 204.97 | 10.33 | 645 | 151412 | 606307 | 70170080 |
Mydriasis | 192.50 | 10.33 | 204 | 151853 | 15949 | 70760438 |
Tremor | 181.28 | 10.33 | 737 | 151320 | 154887 | 70621500 |
Pancytopenia | 173.44 | 10.33 | 54 | 152003 | 151053 | 70625334 |
Coeliac disease | 172.41 | 10.33 | 148 | 151909 | 8885 | 70767502 |
Food allergy | 167.48 | 10.33 | 142 | 151915 | 8382 | 70768005 |
Drug withdrawal syndrome | 153.55 | 10.33 | 262 | 151795 | 32453 | 70743934 |
Sensitisation | 150.64 | 10.33 | 83 | 151974 | 2390 | 70773997 |
Irritability | 148.58 | 10.33 | 282 | 151775 | 37943 | 70738444 |
Sepsis | 147.98 | 10.33 | 184 | 151873 | 244361 | 70532026 |
Polycystic ovaries | 146.94 | 10.33 | 86 | 151971 | 2786 | 70773601 |
Drug interaction | 144.45 | 10.33 | 1348 | 150709 | 380093 | 70396294 |
Asthma | 142.17 | 10.33 | 574 | 151483 | 120219 | 70656168 |
Malignant neoplasm progression | 140.60 | 10.33 | 43 | 152014 | 121696 | 70654691 |
Cardiac failure | 140.31 | 10.33 | 66 | 151991 | 143475 | 70632912 |
Psychiatric decompensation | 138.64 | 10.33 | 84 | 151973 | 2903 | 70773484 |
Exposure via ingestion | 135.59 | 10.33 | 100 | 151957 | 4815 | 70771572 |
General physical health deterioration | 135.20 | 10.33 | 185 | 151872 | 235846 | 70540541 |
Sinus tachycardia | 132.81 | 10.33 | 251 | 151806 | 33662 | 70742725 |
Postmortem blood drug level increased | 131.66 | 10.33 | 53 | 152004 | 730 | 70775657 |
Immunodeficiency | 128.58 | 10.33 | 173 | 151884 | 17382 | 70759005 |
Platelet count decreased | 125.66 | 10.33 | 118 | 151939 | 178104 | 70598283 |
Hyperhidrosis | 124.08 | 10.33 | 585 | 151472 | 131001 | 70645386 |
Ejection fraction | 123.74 | 10.33 | 65 | 151992 | 1697 | 70774690 |
Myoclonus | 119.66 | 10.33 | 208 | 151849 | 26147 | 70750240 |
Renal impairment | 118.07 | 10.33 | 82 | 151975 | 143855 | 70632532 |
Hyperkalaemia | 117.19 | 10.33 | 41 | 152016 | 106550 | 70669837 |
Dyspnoea | 117.12 | 10.33 | 1072 | 150985 | 768988 | 70007399 |
Hyperreflexia | 112.61 | 10.33 | 107 | 151950 | 7335 | 70769052 |
Headache | 111.42 | 10.33 | 1804 | 150253 | 578601 | 70197786 |
Depression suicidal | 110.88 | 10.33 | 72 | 151985 | 2815 | 70773572 |
Disease progression | 110.13 | 10.33 | 104 | 151953 | 156568 | 70619819 |
Loss of personal independence in daily activities | 110.04 | 10.33 | 416 | 151641 | 84494 | 70691893 |
Foot deformity | 107.09 | 10.33 | 173 | 151884 | 20482 | 70755905 |
Atrial fibrillation | 107.05 | 10.33 | 143 | 151914 | 184205 | 70592182 |
Paranoia | 105.32 | 10.33 | 156 | 151901 | 17132 | 70759255 |
Joint dislocation | 104.60 | 10.33 | 142 | 151915 | 14389 | 70761998 |
Tearfulness | 103.52 | 10.33 | 86 | 151971 | 4934 | 70771453 |
Lupus-like syndrome | 102.48 | 10.33 | 125 | 151932 | 11390 | 70764997 |
Tardive dyskinesia | 100.31 | 10.33 | 115 | 151942 | 9814 | 70766573 |
Feeling abnormal | 99.87 | 10.33 | 583 | 151474 | 141736 | 70634651 |
Insomnia | 94.29 | 10.33 | 793 | 151264 | 217013 | 70559374 |
Anger | 91.78 | 10.33 | 141 | 151916 | 15991 | 70760396 |
Multiple organ dysfunction syndrome | 91.43 | 10.33 | 60 | 151997 | 108455 | 70667932 |
Pneumonia | 90.49 | 10.33 | 830 | 151227 | 595402 | 70180985 |
Diarrhoea | 90.31 | 10.33 | 1162 | 150895 | 782179 | 69994208 |
Withdrawal syndrome | 89.78 | 10.33 | 178 | 151879 | 24726 | 70751661 |
Sleep apnoea syndrome | 87.24 | 10.33 | 207 | 151850 | 32506 | 70743881 |
Migraine | 87.13 | 10.33 | 346 | 151711 | 71892 | 70704495 |
Drug hypersensitivity | 86.73 | 10.33 | 902 | 151155 | 261557 | 70514830 |
Exostosis | 85.32 | 10.33 | 128 | 151929 | 14217 | 70762170 |
Retinitis | 85.23 | 10.33 | 71 | 151986 | 4089 | 70772298 |
Peripheral swelling | 83.40 | 10.33 | 246 | 151811 | 236317 | 70540070 |
Lower respiratory tract infection | 82.56 | 10.33 | 71 | 151986 | 111842 | 70664545 |
Bursitis | 82.50 | 10.33 | 179 | 151878 | 26494 | 70749893 |
Panic attack | 82.05 | 10.33 | 160 | 151897 | 21959 | 70754428 |
Crying | 81.88 | 10.33 | 156 | 151901 | 21043 | 70755344 |
Septic shock | 81.87 | 10.33 | 72 | 151985 | 112186 | 70664201 |
Mental status changes | 81.62 | 10.33 | 309 | 151748 | 62792 | 70713595 |
Haemoglobin decreased | 81.61 | 10.33 | 201 | 151856 | 204958 | 70571429 |
Depressive symptom | 81.28 | 10.33 | 76 | 151981 | 5105 | 70771282 |
Tachycardia | 81.10 | 10.33 | 600 | 151457 | 157946 | 70618441 |
Pupil fixed | 80.60 | 10.33 | 63 | 151994 | 3311 | 70773076 |
Mucosal inflammation | 80.09 | 10.33 | 23 | 152034 | 67827 | 70708560 |
Memory impairment | 79.50 | 10.33 | 401 | 151656 | 92240 | 70684147 |
Swelling | 78.75 | 10.33 | 180 | 151877 | 188359 | 70588028 |
Cardiogenic shock | 78.32 | 10.33 | 212 | 151845 | 36095 | 70740292 |
Major depression | 77.81 | 10.33 | 94 | 151963 | 8480 | 70767907 |
White blood cell count decreased | 73.87 | 10.33 | 159 | 151898 | 169982 | 70606405 |
Hepatic function abnormal | 73.29 | 10.33 | 27 | 152030 | 67969 | 70708418 |
Interstitial lung disease | 72.95 | 10.33 | 70 | 151987 | 104615 | 70671772 |
Sympathomimetic effect | 72.87 | 10.33 | 19 | 152038 | 52 | 70776335 |
Rhinitis allergic | 71.76 | 10.33 | 94 | 151963 | 9201 | 70767186 |
Cholestasis | 71.75 | 10.33 | 9 | 152048 | 47863 | 70728524 |
Bone marrow failure | 71.58 | 10.33 | 10 | 152047 | 49000 | 70727387 |
Postictal state | 70.26 | 10.33 | 44 | 152013 | 1614 | 70774773 |
Infarction | 69.99 | 10.33 | 64 | 151993 | 4178 | 70772209 |
Hallucination | 69.63 | 10.33 | 336 | 151721 | 75924 | 70700463 |
Renal failure | 69.27 | 10.33 | 193 | 151864 | 188877 | 70587510 |
Leukopenia | 68.88 | 10.33 | 76 | 151981 | 106484 | 70669903 |
Carpal tunnel syndrome | 67.71 | 10.33 | 127 | 151930 | 16930 | 70759457 |
Helicobacter infection | 67.30 | 10.33 | 18 | 152039 | 55638 | 70720749 |
Gastrointestinal haemorrhage | 66.91 | 10.33 | 120 | 151937 | 137288 | 70639099 |
Neutrophil count decreased | 66.67 | 10.33 | 49 | 152008 | 83507 | 70692880 |
Disturbance in attention | 66.56 | 10.33 | 223 | 151834 | 42671 | 70733716 |
Pleural effusion | 66.54 | 10.33 | 114 | 151943 | 132750 | 70643637 |
Cytomegalovirus infection | 66.08 | 10.33 | 5 | 152052 | 39753 | 70736634 |
Hepatocellular injury | 65.93 | 10.33 | 10 | 152047 | 46081 | 70730306 |
Clonus | 65.70 | 10.33 | 74 | 151983 | 6194 | 70770193 |
Emotional distress | 65.57 | 10.33 | 202 | 151855 | 36986 | 70739401 |
Therapeutic product effect incomplete | 64.92 | 10.33 | 460 | 151597 | 119422 | 70656965 |
Psychotic disorder | 64.82 | 10.33 | 203 | 151854 | 37498 | 70738889 |
Arthropathy | 64.50 | 10.33 | 141 | 151916 | 149916 | 70626471 |
Bronchial neoplasm | 62.46 | 10.33 | 27 | 152030 | 449 | 70775938 |
Hypoglycaemia | 62.43 | 10.33 | 66 | 151991 | 94298 | 70682089 |
Intentional product misuse | 62.39 | 10.33 | 336 | 151721 | 79259 | 70697128 |
Liver disorder | 62.18 | 10.33 | 27 | 152030 | 61541 | 70714846 |
Areflexia | 61.58 | 10.33 | 65 | 151992 | 5057 | 70771330 |
Duodenal ulcer perforation | 60.93 | 10.33 | 17 | 152040 | 51095 | 70725292 |
Pulseless electrical activity | 60.90 | 10.33 | 105 | 151952 | 13110 | 70763277 |
Muscle injury | 60.82 | 10.33 | 6 | 152051 | 38488 | 70737899 |
Lung disorder | 60.47 | 10.33 | 37 | 152020 | 69447 | 70706940 |
Sexual dysfunction | 60.22 | 10.33 | 73 | 151984 | 6608 | 70769779 |
Sleep disorder due to a general medical condition | 60.21 | 10.33 | 92 | 151965 | 10384 | 70766003 |
Infusion related reaction | 60.20 | 10.33 | 219 | 151838 | 197315 | 70579072 |
Melaena | 59.69 | 10.33 | 23 | 152034 | 56332 | 70720055 |
Hyponatraemia | 59.69 | 10.33 | 162 | 151895 | 159925 | 70616462 |
Rubber sensitivity | 59.18 | 10.33 | 38 | 152019 | 1457 | 70774930 |
Folliculitis | 59.17 | 10.33 | 10 | 152047 | 42560 | 70733827 |
Bone erosion | 59.03 | 10.33 | 112 | 151945 | 15061 | 70761326 |
Ascites | 57.36 | 10.33 | 37 | 152020 | 67510 | 70708877 |
Fibromyalgia | 56.67 | 10.33 | 228 | 151829 | 47646 | 70728741 |
Hypokalaemia | 56.60 | 10.33 | 123 | 151934 | 131065 | 70645322 |
Neuropathy peripheral | 56.40 | 10.33 | 117 | 151940 | 126779 | 70649608 |
Depressed mood | 56.18 | 10.33 | 214 | 151843 | 43606 | 70732781 |
Distributive shock | 56.12 | 10.33 | 43 | 152014 | 2194 | 70774193 |
Nasal turbinate hypertrophy | 56.01 | 10.33 | 27 | 152030 | 584 | 70775803 |
Cerebral haemorrhage | 55.39 | 10.33 | 23 | 152034 | 53841 | 70722546 |
Blister | 55.31 | 10.33 | 81 | 151976 | 100445 | 70675942 |
Product quality issue | 53.88 | 10.33 | 166 | 151891 | 30395 | 70745992 |
Plasma cell myeloma | 53.30 | 10.33 | 47 | 152010 | 73154 | 70703233 |
Nicotine dependence | 52.79 | 10.33 | 29 | 152028 | 830 | 70775557 |
Psychomotor skills impaired | 52.63 | 10.33 | 55 | 152002 | 4229 | 70772158 |
Stomatitis | 52.59 | 10.33 | 124 | 151933 | 128387 | 70648000 |
Pneumocystis jirovecii pneumonia | 52.30 | 10.33 | 3 | 152054 | 30079 | 70746308 |
Jaundice | 52.17 | 10.33 | 21 | 152036 | 50087 | 70726300 |
Cholecystitis chronic | 52.00 | 10.33 | 81 | 151976 | 9295 | 70767092 |
Akathisia | 51.91 | 10.33 | 94 | 151963 | 12199 | 70764188 |
Cerebral venous thrombosis | 51.68 | 10.33 | 43 | 152014 | 2472 | 70773915 |
Gamma-glutamyltransferase increased | 51.55 | 10.33 | 22 | 152035 | 50663 | 70725724 |
Incorrect route of product administration | 51.54 | 10.33 | 149 | 151908 | 26343 | 70750044 |
Oesophageal spasm | 51.19 | 10.33 | 47 | 152010 | 3084 | 70773303 |
Endometrial ablation | 50.63 | 10.33 | 28 | 152029 | 812 | 70775575 |
Brugada syndrome | 50.63 | 10.33 | 31 | 152026 | 1092 | 70775295 |
International normalised ratio increased | 50.61 | 10.33 | 59 | 151998 | 80667 | 70695720 |
Nephrectomy | 50.45 | 10.33 | 37 | 152020 | 1766 | 70774621 |
Rhinitis perennial | 50.13 | 10.33 | 21 | 152036 | 322 | 70776065 |
Brain injury | 49.77 | 10.33 | 85 | 151972 | 10532 | 70765855 |
Unresponsive to stimuli | 49.72 | 10.33 | 232 | 151825 | 51699 | 70724688 |
Hostility | 49.36 | 10.33 | 40 | 152017 | 2215 | 70774172 |
Joint swelling | 48.74 | 10.33 | 330 | 151727 | 252881 | 70523506 |
Epistaxis | 48.73 | 10.33 | 91 | 151966 | 102536 | 70673851 |
Multiple sclerosis relapse | 48.65 | 10.33 | 202 | 151855 | 42815 | 70733572 |
Mental disorder | 48.49 | 10.33 | 152 | 151905 | 28088 | 70748299 |
Gastrooesophageal reflux disease | 48.26 | 10.33 | 347 | 151710 | 90492 | 70685895 |
Product residue present | 48.24 | 10.33 | 47 | 152010 | 3323 | 70773064 |
Therapeutic response unexpected | 48.21 | 10.33 | 115 | 151942 | 18116 | 70758271 |
Persistent genital arousal disorder | 48.08 | 10.33 | 20 | 152037 | 301 | 70776086 |
Blood creatinine increased | 48.01 | 10.33 | 152 | 151905 | 142849 | 70633538 |
Off label use | 47.73 | 10.33 | 1221 | 150836 | 741839 | 70034548 |
Libido increased | 47.05 | 10.33 | 36 | 152021 | 1833 | 70774554 |
Hepatic failure | 47.00 | 10.33 | 33 | 152024 | 57592 | 70718795 |
Thinking abnormal | 46.93 | 10.33 | 89 | 151968 | 11962 | 70764425 |
Libido decreased | 46.42 | 10.33 | 55 | 152002 | 4861 | 70771526 |
Gastrointestinal disorder | 46.18 | 10.33 | 98 | 151959 | 105329 | 70671058 |
Mania | 46.14 | 10.33 | 109 | 151948 | 17065 | 70759322 |
C-reactive protein abnormal | 43.85 | 10.33 | 14 | 152043 | 38565 | 70737822 |
Hypothyroidism | 43.50 | 10.33 | 204 | 151853 | 45551 | 70730836 |
Product odour abnormal | 43.15 | 10.33 | 29 | 152028 | 1202 | 70775185 |
Impaired healing | 42.83 | 10.33 | 58 | 151999 | 74316 | 70702071 |
Rash maculo-papular | 42.49 | 10.33 | 28 | 152029 | 50517 | 70725870 |
Muscle twitching | 41.98 | 10.33 | 115 | 151942 | 19712 | 70756675 |
Autonomic nervous system imbalance | 41.73 | 10.33 | 49 | 152008 | 4290 | 70772097 |
Respiratory failure | 41.54 | 10.33 | 203 | 151854 | 168532 | 70607855 |
Pneumonitis | 41.04 | 10.33 | 34 | 152023 | 54563 | 70721824 |
Vision blurred | 40.60 | 10.33 | 345 | 151712 | 94639 | 70681748 |
Toxic epidermal necrolysis | 40.50 | 10.33 | 17 | 152040 | 39540 | 70736847 |
Haematuria | 40.35 | 10.33 | 46 | 152011 | 63527 | 70712860 |
Tinnitus | 40.22 | 10.33 | 169 | 151888 | 36007 | 70740380 |
Agranulocytosis | 40.17 | 10.33 | 18 | 152039 | 40280 | 70736107 |
Drug reaction with eosinophilia and systemic symptoms | 40.17 | 10.33 | 39 | 152018 | 57974 | 70718413 |
Rash | 40.05 | 10.33 | 813 | 151244 | 509749 | 70266638 |
Joint stiffness | 39.63 | 10.33 | 165 | 151892 | 35011 | 70741376 |
Blood test abnormal | 39.63 | 10.33 | 93 | 151964 | 14497 | 70761890 |
Laryngitis | 39.35 | 10.33 | 89 | 151968 | 13542 | 70762845 |
Burning sensation | 39.29 | 10.33 | 220 | 151837 | 52650 | 70723737 |
Sedation | 39.18 | 10.33 | 201 | 151856 | 46530 | 70729857 |
Drug eruption | 38.82 | 10.33 | 18 | 152039 | 39478 | 70736909 |
Upper gastrointestinal haemorrhage | 38.54 | 10.33 | 16 | 152041 | 37461 | 70738926 |
Disseminated intravascular coagulation | 38.53 | 10.33 | 12 | 152045 | 33586 | 70742801 |
Hepatic cirrhosis | 38.50 | 10.33 | 149 | 151908 | 30582 | 70745805 |
Mood altered | 38.37 | 10.33 | 99 | 151958 | 16376 | 70760011 |
Sleep-related eating disorder | 38.31 | 10.33 | 22 | 152035 | 687 | 70775700 |
Syncope | 38.17 | 10.33 | 204 | 151853 | 165505 | 70610882 |
Lactic acidosis | 38.16 | 10.33 | 50 | 152007 | 64974 | 70711413 |
Bronchial haemorrhage | 37.73 | 10.33 | 27 | 152030 | 1240 | 70775147 |
Product complaint | 37.72 | 10.33 | 82 | 151975 | 12149 | 70764238 |
Euphoric mood | 37.49 | 10.33 | 59 | 151998 | 6830 | 70769557 |
Treatment failure | 37.49 | 10.33 | 170 | 151887 | 143972 | 70632415 |
Asthenia | 37.32 | 10.33 | 724 | 151333 | 456942 | 70319445 |
Weight increased | 37.29 | 10.33 | 728 | 151329 | 241603 | 70534784 |
Myelodysplastic syndrome | 37.23 | 10.33 | 9 | 152048 | 29776 | 70746611 |
Endometriosis | 37.02 | 10.33 | 40 | 152017 | 3196 | 70773191 |
Nightmare | 36.89 | 10.33 | 118 | 151939 | 22038 | 70754349 |
Osteonecrosis of jaw | 36.85 | 10.33 | 21 | 152036 | 40981 | 70735406 |
Oesophageal pain | 36.67 | 10.33 | 43 | 152014 | 3759 | 70772628 |
Affective disorder | 36.55 | 10.33 | 61 | 151996 | 7418 | 70768969 |
Bipolar disorder | 35.78 | 10.33 | 61 | 151996 | 7547 | 70768840 |
Psoriasis | 35.68 | 10.33 | 345 | 151712 | 98088 | 70678299 |
Fluid retention | 35.34 | 10.33 | 245 | 151812 | 63140 | 70713247 |
Hypomagnesaemia | 35.06 | 10.33 | 22 | 152035 | 40742 | 70735645 |
Obsessive-compulsive disorder | 34.95 | 10.33 | 50 | 152007 | 5320 | 70771067 |
Hallucination, visual | 34.94 | 10.33 | 140 | 151917 | 29197 | 70747190 |
Vertigo | 34.85 | 10.33 | 242 | 151815 | 62401 | 70713986 |
Psychomotor retardation | 34.79 | 10.33 | 51 | 152006 | 5547 | 70770840 |
Blood lactate dehydrogenase increased | 34.53 | 10.33 | 16 | 152041 | 35111 | 70741276 |
Upper respiratory tract infection | 34.43 | 10.33 | 289 | 151768 | 78985 | 70697402 |
Bronchopulmonary aspergillosis | 33.90 | 10.33 | 3 | 152054 | 20999 | 70755388 |
Acute myeloid leukaemia | 33.82 | 10.33 | 12 | 152045 | 30928 | 70745459 |
Intentional self-injury | 33.75 | 10.33 | 146 | 151911 | 31504 | 70744883 |
Haematemesis | 33.56 | 10.33 | 33 | 152024 | 48764 | 70727623 |
Pruritus | 33.48 | 10.33 | 530 | 151527 | 345030 | 70431357 |
Decreased interest | 33.32 | 10.33 | 39 | 152018 | 3402 | 70772985 |
Anaphylactic shock | 33.20 | 10.33 | 14 | 152043 | 32476 | 70743911 |
Prostate cancer | 32.54 | 10.33 | 13 | 152044 | 31150 | 70745237 |
Drug resistance | 32.31 | 10.33 | 21 | 152036 | 38169 | 70738218 |
Dissociation | 32.26 | 10.33 | 38 | 152019 | 3338 | 70773049 |
Polyneuropathy | 32.15 | 10.33 | 4 | 152053 | 21411 | 70754976 |
Obesity | 32.08 | 10.33 | 128 | 151929 | 26643 | 70749744 |
Feeling jittery | 31.81 | 10.33 | 74 | 151983 | 11469 | 70764918 |
Colitis | 31.71 | 10.33 | 55 | 152002 | 63759 | 70712628 |
Substance abuse | 31.55 | 10.33 | 67 | 151990 | 9770 | 70766617 |
Restless legs syndrome | 31.47 | 10.33 | 99 | 151958 | 18329 | 70758058 |
Posterior reversible encephalopathy syndrome | 31.24 | 10.33 | 7 | 152050 | 24395 | 70751992 |
Hallucinations, mixed | 31.24 | 10.33 | 52 | 152005 | 6310 | 70770077 |
Cough | 31.20 | 10.33 | 500 | 151557 | 324877 | 70451510 |
Haemophagocytic lymphohistiocytosis | 31.13 | 10.33 | 3 | 152054 | 19609 | 70756778 |
Hyponatraemic coma | 30.98 | 10.33 | 9 | 152048 | 41 | 70776346 |
Hepatitis | 30.82 | 10.33 | 37 | 152020 | 49943 | 70726444 |
Haemoptysis | 30.77 | 10.33 | 39 | 152018 | 51413 | 70724974 |
Urine amphetamine positive | 30.59 | 10.33 | 10 | 152047 | 72 | 70776315 |
Sleep paralysis | 30.48 | 10.33 | 18 | 152039 | 593 | 70775794 |
Eosinophilia | 30.44 | 10.33 | 25 | 152032 | 40294 | 70736093 |
Hypercalcaemia | 30.35 | 10.33 | 18 | 152039 | 34367 | 70742020 |
Vomiting | 30.12 | 10.33 | 1006 | 151051 | 592105 | 70184282 |
Dysphemia | 29.98 | 10.33 | 36 | 152021 | 3227 | 70773160 |
Impaired work ability | 29.97 | 10.33 | 90 | 151967 | 16250 | 70760137 |
Device expulsion | 29.64 | 10.33 | 110 | 151947 | 22136 | 70754251 |
Complication of device insertion | 29.48 | 10.33 | 46 | 152011 | 5286 | 70771101 |
Heart rate decreased | 29.42 | 10.33 | 55 | 152002 | 61960 | 70714427 |
Abnormal dreams | 29.25 | 10.33 | 68 | 151989 | 10535 | 70765852 |
Rash erythematous | 28.89 | 10.33 | 200 | 151857 | 51518 | 70724869 |
Decreased appetite | 28.66 | 10.33 | 470 | 151587 | 304310 | 70472077 |
Reversible cerebral vasoconstriction syndrome | 28.65 | 10.33 | 32 | 152025 | 2653 | 70773734 |
Sleep disorder due to general medical condition, insomnia type | 28.44 | 10.33 | 21 | 152036 | 35711 | 70740676 |
Metastases to liver | 28.35 | 10.33 | 10 | 152047 | 25868 | 70750519 |
Haemorrhage | 28.18 | 10.33 | 89 | 151968 | 83726 | 70692661 |
Hallucination, auditory | 28.17 | 10.33 | 95 | 151962 | 18233 | 70758154 |
Nasopharyngitis | 27.95 | 10.33 | 323 | 151734 | 221883 | 70554504 |
Pericardial effusion | 27.87 | 10.33 | 29 | 152028 | 41747 | 70734640 |
Cardiac failure congestive | 27.84 | 10.33 | 173 | 151884 | 135284 | 70641103 |
Hepatotoxicity | 27.73 | 10.33 | 32 | 152025 | 43954 | 70732433 |
Corneal reflex decreased | 27.68 | 10.33 | 14 | 152043 | 337 | 70776050 |
Thrombotic microangiopathy | 27.63 | 10.33 | 3 | 152054 | 17845 | 70758542 |
Abnormal behaviour | 27.51 | 10.33 | 147 | 151910 | 34562 | 70741825 |
Neoplasm progression | 27.34 | 10.33 | 34 | 152023 | 45194 | 70731193 |
Dyspnoea exertional | 27.28 | 10.33 | 82 | 151975 | 78348 | 70698039 |
Skin ulcer | 27.26 | 10.33 | 38 | 152019 | 48107 | 70728280 |
Disorientation | 27.23 | 10.33 | 215 | 151842 | 57708 | 70718679 |
Apathy | 27.16 | 10.33 | 71 | 151986 | 11837 | 70764550 |
Tongue biting | 26.87 | 10.33 | 26 | 152031 | 1823 | 70774564 |
Sputum purulent | 26.84 | 10.33 | 22 | 152035 | 1238 | 70775149 |
Pneumothorax | 26.63 | 10.33 | 11 | 152046 | 25835 | 70750552 |
Systemic lupus erythematosus | 26.60 | 10.33 | 120 | 151937 | 101782 | 70674605 |
Bradyphrenia | 26.58 | 10.33 | 63 | 151994 | 9883 | 70766504 |
Nephropathy toxic | 26.52 | 10.33 | 4 | 152053 | 18510 | 70757877 |
Anuria | 26.48 | 10.33 | 5 | 152052 | 19648 | 70756739 |
Anti-neutrophil cytoplasmic antibody positive vasculitis | 26.48 | 10.33 | 34 | 152023 | 3263 | 70773124 |
Bladder cancer | 26.43 | 10.33 | 3 | 152054 | 17239 | 70759148 |
Cerebral infarction | 26.35 | 10.33 | 32 | 152025 | 42977 | 70733410 |
Blood pressure systolic increased | 26.11 | 10.33 | 52 | 152005 | 57207 | 70719180 |
Amnesia | 25.85 | 10.33 | 196 | 151861 | 51959 | 70724428 |
Electroencephalogram abnormal | 25.85 | 10.33 | 43 | 152014 | 5215 | 70771172 |
Shock haemorrhagic | 25.73 | 10.33 | 4 | 152053 | 18102 | 70758285 |
Pericarditis | 25.72 | 10.33 | 94 | 151963 | 84611 | 70691776 |
Multiple sclerosis | 25.71 | 10.33 | 115 | 151942 | 25170 | 70751217 |
Tubulointerstitial nephritis | 25.60 | 10.33 | 20 | 152037 | 33056 | 70743331 |
Peritonitis | 25.58 | 10.33 | 12 | 152045 | 26147 | 70750240 |
Anorgasmia | 25.36 | 10.33 | 20 | 152037 | 1065 | 70775322 |
Impulse-control disorder | 25.14 | 10.33 | 24 | 152033 | 1655 | 70774732 |
Basilar artery occlusion | 24.91 | 10.33 | 11 | 152046 | 193 | 70776194 |
Uterine perforation | 24.81 | 10.33 | 45 | 152012 | 5846 | 70770541 |
Nervousness | 24.80 | 10.33 | 132 | 151925 | 30988 | 70745399 |
Economic problem | 24.79 | 10.33 | 27 | 152030 | 2177 | 70774210 |
Pemphigus | 24.66 | 10.33 | 93 | 151964 | 82943 | 70693444 |
Arthralgia | 24.56 | 10.33 | 858 | 151199 | 502532 | 70273855 |
Blood bilirubin increased | 24.33 | 10.33 | 58 | 151999 | 59843 | 70716544 |
Dizziness | 24.29 | 10.33 | 1222 | 150835 | 462919 | 70313468 |
Device related infection | 24.24 | 10.33 | 20 | 152037 | 32165 | 70744222 |
Erythema dyschromicum perstans | 24.07 | 10.33 | 8 | 152049 | 61 | 70776326 |
Mucosal dryness | 24.02 | 10.33 | 32 | 152025 | 3184 | 70773203 |
Dehydration | 23.89 | 10.33 | 341 | 151716 | 225801 | 70550586 |
Injection site mass | 23.85 | 10.33 | 90 | 151967 | 18253 | 70758134 |
Muscle rigidity | 23.83 | 10.33 | 91 | 151966 | 18559 | 70757828 |
Haematoma | 23.81 | 10.33 | 42 | 152015 | 48376 | 70728011 |
Angina pectoris | 23.77 | 10.33 | 42 | 152015 | 48341 | 70728046 |
Transplant rejection | 23.69 | 10.33 | 5 | 152052 | 18166 | 70758221 |
Hand deformity | 23.69 | 10.33 | 100 | 151957 | 86382 | 70690005 |
Dyskinesia | 23.63 | 10.33 | 160 | 151897 | 40914 | 70735473 |
Oedema | 23.57 | 10.33 | 128 | 151929 | 103453 | 70672934 |
Drug specific antibody | 23.47 | 10.33 | 27 | 152030 | 2312 | 70774075 |
Pancreatitis acute | 23.37 | 10.33 | 38 | 152019 | 45186 | 70731201 |
Bronchial disorder | 23.33 | 10.33 | 27 | 152030 | 2327 | 70774060 |
Solar urticaria | 23.31 | 10.33 | 8 | 152049 | 68 | 70776319 |
Pulmonary oedema | 23.25 | 10.33 | 94 | 151963 | 82184 | 70694203 |
Cytokine release syndrome | 23.15 | 10.33 | 14 | 152043 | 26453 | 70749934 |
Aspergillus infection | 23.13 | 10.33 | 5 | 152052 | 17863 | 70758524 |
Orgasm abnormal | 23.04 | 10.33 | 10 | 152047 | 168 | 70776219 |
Anhedonia | 23.03 | 10.33 | 75 | 151982 | 14138 | 70762249 |
Feelings of worthlessness | 23.02 | 10.33 | 14 | 152043 | 487 | 70775900 |
Psychomotor hyperactivity | 22.85 | 10.33 | 79 | 151978 | 15354 | 70761033 |
Pulmonary arterial hypertension | 22.84 | 10.33 | 22 | 152035 | 32833 | 70743554 |
Soft tissue injury | 22.77 | 10.33 | 23 | 152034 | 1699 | 70774688 |
Attention deficit hyperactivity disorder | 22.74 | 10.33 | 30 | 152027 | 2957 | 70773430 |
Alcoholism | 22.72 | 10.33 | 37 | 152020 | 4408 | 70771979 |
Metastases to lung | 22.63 | 10.33 | 4 | 152053 | 16480 | 70759907 |
Device dislocation | 22.61 | 10.33 | 102 | 151955 | 22405 | 70753982 |
Drug screen positive | 22.58 | 10.33 | 43 | 152014 | 5797 | 70770590 |
Pallor | 22.54 | 10.33 | 33 | 152024 | 40941 | 70735446 |
Drug dependence | 22.44 | 10.33 | 147 | 151910 | 37174 | 70739213 |
Brain death | 22.38 | 10.33 | 40 | 152017 | 5138 | 70771249 |
Oedema peripheral | 22.35 | 10.33 | 349 | 151708 | 227742 | 70548645 |
Bacteraemia | 22.34 | 10.33 | 18 | 152039 | 29291 | 70747096 |
Ejection fraction abnormal | 22.32 | 10.33 | 23 | 152034 | 1740 | 70774647 |
Urinary tract infection | 22.28 | 10.33 | 387 | 151670 | 248382 | 70528005 |
C-reactive protein increased | 22.26 | 10.33 | 142 | 151915 | 110375 | 70666012 |
Gambling disorder | 22.25 | 10.33 | 24 | 152033 | 1914 | 70774473 |
Drug tolerance | 22.00 | 10.33 | 49 | 152008 | 7379 | 70769008 |
Hepatic encephalopathy | 21.86 | 10.33 | 10 | 152047 | 22108 | 70754279 |
Irritable bowel syndrome | 21.65 | 10.33 | 48 | 152009 | 50802 | 70725585 |
Central nervous system necrosis | 21.44 | 10.33 | 11 | 152046 | 273 | 70776114 |
Self esteem decreased | 21.38 | 10.33 | 17 | 152040 | 916 | 70775471 |
Rectal haemorrhage | 21.37 | 10.33 | 71 | 151986 | 65760 | 70710627 |
Palmar-plantar erythrodysaesthesia syndrome | 21.33 | 10.33 | 20 | 152037 | 30227 | 70746160 |
Herpes zoster | 21.28 | 10.33 | 102 | 151955 | 85133 | 70691254 |
Dystonia | 21.08 | 10.33 | 91 | 151966 | 19615 | 70756772 |
Accidental exposure to product by child | 21.08 | 10.33 | 28 | 152029 | 2778 | 70773609 |
Dysphoria | 21.07 | 10.33 | 36 | 152021 | 4462 | 70771925 |
Blood pressure fluctuation | 21.03 | 10.33 | 61 | 151996 | 58951 | 70717436 |
Mood swings | 20.77 | 10.33 | 86 | 151971 | 18200 | 70758187 |
Feeling of despair | 20.76 | 10.33 | 27 | 152030 | 2624 | 70773763 |
Basal cell carcinoma | 20.72 | 10.33 | 25 | 152032 | 33673 | 70742714 |
Infusion site scar | 20.71 | 10.33 | 11 | 152046 | 294 | 70776093 |
Clostridium difficile colitis | 20.65 | 10.33 | 19 | 152038 | 28977 | 70747410 |
Infection | 20.48 | 10.33 | 323 | 151734 | 210462 | 70565925 |
Accidental poisoning | 20.37 | 10.33 | 21 | 152036 | 1589 | 70774798 |
Cardiotoxicity | 20.32 | 10.33 | 61 | 151996 | 11009 | 70765378 |
Hypomania | 20.22 | 10.33 | 42 | 152015 | 6030 | 70770357 |
Post-traumatic neck syndrome | 20.18 | 10.33 | 23 | 152034 | 1950 | 70774437 |
Prescribed overdose | 20.12 | 10.33 | 113 | 151944 | 27068 | 70749319 |
Tenosynovitis | 20.06 | 10.33 | 3 | 152054 | 13973 | 70762414 |
Oliguria | 19.92 | 10.33 | 4 | 152053 | 15047 | 70761340 |
Graft versus host disease | 19.87 | 10.33 | 4 | 152053 | 15019 | 70761368 |
Liver injury | 19.81 | 10.33 | 36 | 152021 | 40999 | 70735388 |
Liver function test abnormal | 19.81 | 10.33 | 66 | 151991 | 61080 | 70715307 |
Balance disorder | 19.80 | 10.33 | 287 | 151770 | 89841 | 70686546 |
Treatment noncompliance | 19.80 | 10.33 | 169 | 151888 | 46405 | 70729982 |
Hyperbilirubinaemia | 19.66 | 10.33 | 12 | 152045 | 22556 | 70753831 |
Left ventricular dysfunction | 19.57 | 10.33 | 7 | 152050 | 17950 | 70758437 |
Adrenergic syndrome | 19.50 | 10.33 | 8 | 152049 | 116 | 70776271 |
Hyperglycaemia | 19.48 | 10.33 | 72 | 151985 | 64600 | 70711787 |
Alanine aminotransferase increased | 19.47 | 10.33 | 212 | 151845 | 147268 | 70629119 |
Compulsive shopping | 19.45 | 10.33 | 15 | 152042 | 773 | 70775614 |
Stress | 19.37 | 10.33 | 227 | 151830 | 67739 | 70708648 |
Metastases to bone | 19.35 | 10.33 | 12 | 152045 | 22364 | 70754023 |
Gallbladder disorder | 19.11 | 10.33 | 82 | 151975 | 17630 | 70758757 |
Urine sodium increased | 19.04 | 10.33 | 9 | 152048 | 186 | 70776201 |
Enterococcal infection | 19.04 | 10.33 | 4 | 152053 | 14578 | 70761809 |
Maternal exposure during pregnancy | 18.99 | 10.33 | 157 | 151900 | 115188 | 70661199 |
Serum sickness-like reaction | 18.92 | 10.33 | 13 | 152044 | 559 | 70775828 |
Acute myocardial infarction | 18.92 | 10.33 | 86 | 151971 | 72801 | 70703586 |
Cardiomyopathy acute | 18.83 | 10.33 | 10 | 152047 | 267 | 70776120 |
Electrocardiogram PR prolongation | 18.68 | 10.33 | 19 | 152038 | 1415 | 70774972 |
Sudden death | 18.63 | 10.33 | 11 | 152046 | 21053 | 70755334 |
Delusion | 18.62 | 10.33 | 86 | 151971 | 19079 | 70757308 |
Sternal fracture | 18.50 | 10.33 | 24 | 152033 | 2327 | 70774060 |
Malaise | 18.41 | 10.33 | 750 | 151307 | 432182 | 70344205 |
Haemoglobin urine | 18.40 | 10.33 | 8 | 152049 | 135 | 70776252 |
Respiratory distress | 18.39 | 10.33 | 58 | 151999 | 54592 | 70721795 |
Renal disorder | 18.37 | 10.33 | 142 | 151915 | 37867 | 70738520 |
Binge eating | 18.35 | 10.33 | 12 | 152045 | 475 | 70775912 |
Extra dose administered | 18.28 | 10.33 | 45 | 152012 | 7232 | 70769155 |
Lymphopenia | 18.24 | 10.33 | 19 | 152038 | 27340 | 70749047 |
Blood pressure decreased | 18.22 | 10.33 | 118 | 151939 | 91397 | 70684990 |
Atrioventricular block complete | 18.15 | 10.33 | 5 | 152052 | 15158 | 70761229 |
Rhonchi | 18.11 | 10.33 | 30 | 152027 | 3625 | 70772762 |
Oxygen saturation decreased | 18.04 | 10.33 | 161 | 151896 | 116268 | 70660119 |
Erectile dysfunction | 18.01 | 10.33 | 67 | 151990 | 13495 | 70762892 |
Product dose omission issue | 17.90 | 10.33 | 601 | 151456 | 216867 | 70559520 |
Marital problem | 17.86 | 10.33 | 9 | 152048 | 215 | 70776172 |
Ankle arthroplasty | 17.80 | 10.33 | 17 | 152040 | 1173 | 70775214 |
Somnolence | 17.78 | 10.33 | 596 | 151461 | 215010 | 70561377 |
Sensitivity to weather change | 17.76 | 10.33 | 45 | 152012 | 7360 | 70769027 |
Dermatitis bullous | 17.72 | 10.33 | 3 | 152054 | 12754 | 70763633 |
Partner stress | 17.54 | 10.33 | 10 | 152047 | 308 | 70776079 |
Poor personal hygiene | 17.46 | 10.33 | 12 | 152045 | 516 | 70775871 |
Restlessness | 17.46 | 10.33 | 152 | 151905 | 41976 | 70734411 |
Homicidal ideation | 17.45 | 10.33 | 28 | 152029 | 3295 | 70773092 |
Chronic fatigue syndrome | 17.41 | 10.33 | 17 | 152040 | 1205 | 70775182 |
Pulmonary hypertension | 17.40 | 10.33 | 47 | 152010 | 46489 | 70729898 |
Loss of libido | 17.36 | 10.33 | 24 | 152033 | 2473 | 70773914 |
Dependence | 17.35 | 10.33 | 23 | 152034 | 2277 | 70774110 |
Large intestine anastomosis | 17.35 | 10.33 | 7 | 152050 | 97 | 70776290 |
Adjustment disorder | 17.21 | 10.33 | 27 | 152030 | 3117 | 70773270 |
Cardiac failure acute | 17.14 | 10.33 | 8 | 152049 | 17479 | 70758908 |
Hypertensive crisis | 17.12 | 10.33 | 10 | 152047 | 19252 | 70757135 |
Brain stem syndrome | 17.06 | 10.33 | 14 | 152043 | 789 | 70775598 |
Clostridium difficile infection | 17.06 | 10.33 | 36 | 152021 | 38780 | 70737607 |
Liver function test increased | 16.97 | 10.33 | 29 | 152028 | 33818 | 70742569 |
Mass excision | 16.95 | 10.33 | 10 | 152047 | 329 | 70776058 |
Abdominal pain | 16.92 | 10.33 | 582 | 151475 | 341545 | 70434842 |
Lymphoma | 16.90 | 10.33 | 6 | 152051 | 15456 | 70760931 |
Staphylococcal sepsis | 16.89 | 10.33 | 4 | 152053 | 13423 | 70762964 |
Body temperature decreased | 16.87 | 10.33 | 22 | 152035 | 28650 | 70747737 |
Dyspareunia | 16.79 | 10.33 | 20 | 152037 | 1777 | 70774610 |
Subacute cutaneous lupus erythematosus | 16.77 | 10.33 | 27 | 152030 | 3186 | 70773201 |
Automatism | 16.77 | 10.33 | 8 | 152049 | 169 | 70776218 |
Inadequate analgesia | 16.75 | 10.33 | 31 | 152026 | 4091 | 70772296 |
Supraventricular tachycardia | 16.67 | 10.33 | 85 | 151972 | 19625 | 70756762 |
Generalised anxiety disorder | 16.61 | 10.33 | 21 | 152036 | 1984 | 70774403 |
Biliary dyskinesia | 16.60 | 10.33 | 23 | 152034 | 2376 | 70774011 |
Duodenal ulcer | 16.58 | 10.33 | 6 | 152051 | 15274 | 70761113 |
Gun shot wound | 16.47 | 10.33 | 16 | 152041 | 1127 | 70775260 |
Emotional disorder | 16.46 | 10.33 | 64 | 151993 | 13162 | 70763225 |
Bruxism | 16.36 | 10.33 | 29 | 152028 | 3700 | 70772687 |
Device placement issue | 16.35 | 10.33 | 14 | 152043 | 837 | 70775550 |
Injection site reaction | 16.26 | 10.33 | 171 | 151886 | 49681 | 70726706 |
Hypocalcaemia | 16.25 | 10.33 | 46 | 152011 | 44813 | 70731574 |
Musculoskeletal pain | 16.24 | 10.33 | 120 | 151937 | 90207 | 70686180 |
Enterocolitis | 16.23 | 10.33 | 4 | 152053 | 13062 | 70763325 |
Job dissatisfaction | 16.20 | 10.33 | 6 | 152051 | 65 | 70776322 |
Oscillopsia | 16.19 | 10.33 | 8 | 152049 | 183 | 70776204 |
Gastric ulcer | 16.16 | 10.33 | 27 | 152030 | 31763 | 70744624 |
Compartment syndrome | 16.09 | 10.33 | 32 | 152025 | 4454 | 70771933 |
Choreoathetosis | 16.06 | 10.33 | 18 | 152039 | 1498 | 70774889 |
Injury | 16.05 | 10.33 | 212 | 151845 | 65033 | 70711354 |
Eczema | 15.99 | 10.33 | 30 | 152027 | 33751 | 70742636 |
Haemolytic anaemia | 15.97 | 10.33 | 8 | 152049 | 16786 | 70759601 |
Urine osmolarity increased | 15.91 | 10.33 | 9 | 152048 | 273 | 70776114 |
Bezoar | 15.79 | 10.33 | 22 | 152035 | 2284 | 70774103 |
Haematochezia | 15.71 | 10.33 | 92 | 151965 | 72989 | 70703398 |
Clonic convulsion | 15.58 | 10.33 | 16 | 152041 | 1205 | 70775182 |
Wound infection fungal | 15.58 | 10.33 | 8 | 152049 | 199 | 70776188 |
Impulsive behaviour | 15.56 | 10.33 | 24 | 152033 | 2730 | 70773657 |
Tachyphrenia | 15.48 | 10.33 | 20 | 152037 | 1931 | 70774456 |
Corneal light reflex test abnormal | 15.44 | 10.33 | 3 | 152054 | 0 | 70776387 |
Thalamic infarction | 15.38 | 10.33 | 16 | 152041 | 1224 | 70775163 |
Poor quality sleep | 15.33 | 10.33 | 85 | 151972 | 20264 | 70756123 |
Pseudomonas infection | 15.33 | 10.33 | 11 | 152046 | 18983 | 70757404 |
Postmortem blood drug level abnormal | 15.25 | 10.33 | 12 | 152045 | 637 | 70775750 |
Premature delivery | 15.12 | 10.33 | 14 | 152043 | 21290 | 70755097 |
Wound | 15.08 | 10.33 | 137 | 151920 | 98595 | 70677792 |
Oculocephalogyric reflex absent | 15.06 | 10.33 | 5 | 152052 | 38 | 70776349 |
Synovitis | 15.03 | 10.33 | 191 | 151866 | 129037 | 70647350 |
Suicidal behaviour | 15.03 | 10.33 | 25 | 152032 | 3031 | 70773356 |
Respiratory tract infection | 14.98 | 10.33 | 44 | 152013 | 42354 | 70734033 |
Blood pressure diastolic decreased | 14.94 | 10.33 | 20 | 152037 | 25760 | 70750627 |
Dry mouth | 14.94 | 10.33 | 223 | 151834 | 70234 | 70706153 |
Hypoxia | 14.93 | 10.33 | 128 | 151929 | 93216 | 70683171 |
Decorticate posture | 14.93 | 10.33 | 9 | 152048 | 308 | 70776079 |
Bronchiectasis | 14.82 | 10.33 | 8 | 152049 | 16089 | 70760298 |
Cannabinoid hyperemesis syndrome | 14.73 | 10.33 | 5 | 152052 | 41 | 70776346 |
Acute respiratory failure | 14.73 | 10.33 | 62 | 151995 | 53603 | 70722784 |
Accidental overdose | 14.70 | 10.33 | 127 | 151930 | 34994 | 70741393 |
Orthostatic hypotension | 14.69 | 10.33 | 59 | 151998 | 51684 | 70724703 |
Lymphoedema | 14.69 | 10.33 | 55 | 152002 | 11114 | 70765273 |
Infusion site discomfort | 14.57 | 10.33 | 14 | 152043 | 973 | 70775414 |
Acute hepatic failure | 14.54 | 10.33 | 23 | 152034 | 27649 | 70748738 |
Injection site induration | 14.52 | 10.33 | 48 | 152009 | 9120 | 70767267 |
Hypoaesthesia | 14.51 | 10.33 | 432 | 151625 | 153307 | 70623080 |
Coagulopathy | 14.47 | 10.33 | 31 | 152026 | 33218 | 70743169 |
Electrolyte imbalance | 14.42 | 10.33 | 22 | 152035 | 26839 | 70749548 |
Body height decreased | 14.40 | 10.33 | 43 | 152014 | 7740 | 70768647 |
Priapism | 14.36 | 10.33 | 29 | 152028 | 4081 | 70772306 |
Bipolar I disorder | 14.20 | 10.33 | 19 | 152038 | 1898 | 70774489 |
Hyperthermia | 14.17 | 10.33 | 72 | 151985 | 16599 | 70759788 |
Anticholinergic syndrome | 14.16 | 10.33 | 24 | 152033 | 2956 | 70773431 |
Drug titration error | 14.15 | 10.33 | 14 | 152043 | 1009 | 70775378 |
Post-traumatic stress disorder | 14.11 | 10.33 | 30 | 152027 | 4377 | 70772010 |
Blood potassium increased | 14.08 | 10.33 | 23 | 152034 | 27303 | 70749084 |
Ischaemic stroke | 14.04 | 10.33 | 28 | 152029 | 30792 | 70745595 |
Vaginal haemorrhage | 14.01 | 10.33 | 83 | 151974 | 20269 | 70756118 |
Stoma site ulcer | 13.93 | 10.33 | 8 | 152049 | 250 | 70776137 |
Hypophosphataemia | 13.78 | 10.33 | 9 | 152048 | 16317 | 70760070 |
Ear infection | 13.77 | 10.33 | 106 | 151951 | 28230 | 70748157 |
Muscular weakness | 13.76 | 10.33 | 211 | 151846 | 138125 | 70638262 |
Pre-existing condition improved | 13.71 | 10.33 | 32 | 152025 | 4970 | 70771417 |
Persecutory delusion | 13.61 | 10.33 | 30 | 152027 | 4487 | 70771900 |
Arthritis | 13.61 | 10.33 | 290 | 151767 | 97690 | 70678697 |
Ankle fracture | 13.56 | 10.33 | 67 | 151990 | 15277 | 70761110 |
Social anxiety disorder | 13.49 | 10.33 | 10 | 152047 | 485 | 70775902 |
Hypervolaemia | 13.46 | 10.33 | 42 | 152015 | 39664 | 70736723 |
Faeces discoloured | 13.41 | 10.33 | 23 | 152034 | 26786 | 70749601 |
Carbon monoxide poisoning | 13.40 | 10.33 | 8 | 152049 | 269 | 70776118 |
Abortion spontaneous | 13.40 | 10.33 | 100 | 151957 | 26379 | 70750008 |
Non-alcoholic steatohepatitis | 13.38 | 10.33 | 19 | 152038 | 2008 | 70774379 |
Pituitary hyperplasia | 13.37 | 10.33 | 3 | 152054 | 3 | 70776384 |
Pharyngeal exudate | 13.37 | 10.33 | 3 | 152054 | 3 | 70776384 |
Sedation complication | 13.35 | 10.33 | 6 | 152051 | 13404 | 70762983 |
Abulia | 13.31 | 10.33 | 13 | 152044 | 922 | 70775465 |
Hypotonic urinary bladder | 13.27 | 10.33 | 5 | 152052 | 57 | 70776330 |
Homeless | 13.15 | 10.33 | 6 | 152051 | 114 | 70776273 |
Illusion | 13.15 | 10.33 | 17 | 152040 | 1642 | 70774745 |
Hyperammonaemia | 13.08 | 10.33 | 3 | 152054 | 10290 | 70766097 |
Cardiac failure chronic | 13.04 | 10.33 | 3 | 152054 | 10266 | 70766121 |
Aggression | 13.01 | 10.33 | 160 | 151897 | 48286 | 70728101 |
Erythema induratum | 12.91 | 10.33 | 7 | 152050 | 195 | 70776192 |
Hallucination, tactile | 12.90 | 10.33 | 10 | 152047 | 519 | 70775868 |
Substance use disorder | 12.89 | 10.33 | 11 | 152046 | 655 | 70775732 |
Pelvic pain | 12.84 | 10.33 | 54 | 152003 | 11506 | 70764881 |
Face oedema | 12.82 | 10.33 | 22 | 152035 | 25617 | 70750770 |
Road traffic accident | 12.78 | 10.33 | 122 | 151935 | 34560 | 70741827 |
Initial insomnia | 12.77 | 10.33 | 36 | 152021 | 6273 | 70770114 |
Cytopenia | 12.76 | 10.33 | 11 | 152046 | 17312 | 70759075 |
Peripheral sensory neuropathy | 12.73 | 10.33 | 5 | 152052 | 12105 | 70764282 |
Food craving | 12.71 | 10.33 | 16 | 152041 | 1505 | 70774882 |
Red blood cell count decreased | 12.68 | 10.33 | 63 | 151994 | 52098 | 70724289 |
Flat affect | 12.65 | 10.33 | 18 | 152039 | 1905 | 70774482 |
Pupillary reflex impaired | 12.63 | 10.33 | 24 | 152033 | 3230 | 70773157 |
Lower gastrointestinal haemorrhage | 12.58 | 10.33 | 8 | 152049 | 14712 | 70761675 |
Cardiac disorder | 12.58 | 10.33 | 188 | 151869 | 59227 | 70717160 |
Personality disorder | 12.57 | 10.33 | 33 | 152024 | 5515 | 70770872 |
Purpura | 12.54 | 10.33 | 12 | 152045 | 17963 | 70758424 |
Blood pressure systolic abnormal | 12.50 | 10.33 | 6 | 152051 | 12903 | 70763484 |
Pancreatic carcinoma | 12.50 | 10.33 | 6 | 152051 | 12898 | 70763489 |
Dermatillomania | 12.47 | 10.33 | 7 | 152050 | 209 | 70776178 |
Blood calcium decreased | 12.47 | 10.33 | 27 | 152030 | 28819 | 70747568 |
Kidney transplant rejection | 12.47 | 10.33 | 3 | 152054 | 9958 | 70766429 |
Heavy menstrual bleeding | 12.43 | 10.33 | 57 | 152000 | 12608 | 70763779 |
Hyperuricaemia | 12.43 | 10.33 | 4 | 152053 | 10962 | 70765425 |
Renal tubular necrosis | 12.42 | 10.33 | 19 | 152038 | 23152 | 70753235 |
Abscess sterile | 12.41 | 10.33 | 5 | 152052 | 69 | 70776318 |
Femur fracture | 12.40 | 10.33 | 38 | 152019 | 36094 | 70740293 |
Gastrointestinal sounds abnormal | 12.40 | 10.33 | 31 | 152026 | 5030 | 70771357 |
Ventricular tachycardia | 12.38 | 10.33 | 126 | 151931 | 36297 | 70740090 |
Glossodynia | 12.36 | 10.33 | 122 | 151935 | 86365 | 70690022 |
Anaphylactic reaction | 12.36 | 10.33 | 102 | 151955 | 74872 | 70701515 |
Cutaneous lupus erythematosus | 12.31 | 10.33 | 22 | 152035 | 2826 | 70773561 |
Blood lactic acid increased | 12.26 | 10.33 | 52 | 152005 | 11121 | 70765266 |
Anti-cyclic citrullinated peptide antibody positive | 12.25 | 10.33 | 94 | 151963 | 70091 | 70706296 |
Drug tolerance decreased | 12.23 | 10.33 | 3 | 152054 | 9830 | 70766557 |
Drug screen false positive | 12.22 | 10.33 | 13 | 152044 | 1020 | 70775367 |
Panic disorder | 12.22 | 10.33 | 22 | 152035 | 2842 | 70773545 |
Forced expiratory volume decreased | 12.22 | 10.33 | 39 | 152018 | 7275 | 70769112 |
Subdural haematoma | 12.19 | 10.33 | 28 | 152029 | 29270 | 70747117 |
Binge drinking | 12.16 | 10.33 | 3 | 152054 | 6 | 70776381 |
Narcolepsy | 12.15 | 10.33 | 14 | 152043 | 1201 | 70775186 |
Encephalitis | 12.15 | 10.33 | 7 | 152050 | 13578 | 70762809 |
Persistent depressive disorder | 12.14 | 10.33 | 13 | 152044 | 1028 | 70775359 |
Vaginal odour | 12.13 | 10.33 | 8 | 152049 | 321 | 70776066 |
Concussion | 12.12 | 10.33 | 43 | 152014 | 8466 | 70767921 |
Abscess | 11.99 | 10.33 | 16 | 152041 | 20638 | 70755749 |
Dysarthria | 11.98 | 10.33 | 194 | 151863 | 62119 | 70714268 |
Ileus | 11.94 | 10.33 | 21 | 152036 | 24216 | 70752171 |
Vasoplegia syndrome | 11.91 | 10.33 | 23 | 152034 | 3133 | 70773254 |
Klebsiella infection | 11.90 | 10.33 | 8 | 152049 | 14284 | 70762103 |
Pain in jaw | 11.89 | 10.33 | 49 | 152008 | 42620 | 70733767 |
Rheumatoid nodule | 11.80 | 10.33 | 9 | 152048 | 15058 | 70761329 |
Injection site abscess | 11.75 | 10.33 | 15 | 152042 | 1431 | 70774956 |
Oesophagitis | 11.74 | 10.33 | 19 | 152038 | 22633 | 70753754 |
Gastric haemorrhage | 11.73 | 10.33 | 8 | 152049 | 14177 | 70762210 |
Cerebrovascular accident | 11.64 | 10.33 | 227 | 151830 | 143243 | 70633144 |
Visual impairment | 11.62 | 10.33 | 239 | 151818 | 80011 | 70696376 |
Rhinorrhoea | 11.54 | 10.33 | 89 | 151968 | 66282 | 70710105 |
Parkinsonism | 11.53 | 10.33 | 64 | 151993 | 15261 | 70761126 |
Cortisol increased | 11.53 | 10.33 | 9 | 152048 | 472 | 70775915 |
Right ventricular systolic pressure decreased | 11.52 | 10.33 | 5 | 152052 | 84 | 70776303 |
Ideas of reference | 11.48 | 10.33 | 6 | 152051 | 155 | 70776232 |
Chills | 11.47 | 10.33 | 230 | 151827 | 144556 | 70631831 |
Tongue spasm | 11.47 | 10.33 | 5 | 152052 | 85 | 70776302 |
Ejaculation failure | 11.44 | 10.33 | 8 | 152049 | 354 | 70776033 |
Increased appetite | 11.35 | 10.33 | 49 | 152008 | 10564 | 70765823 |
Rales | 11.31 | 10.33 | 12 | 152045 | 17123 | 70759264 |
Partial seizures | 11.29 | 10.33 | 41 | 152016 | 8164 | 70768223 |
Bankruptcy | 11.27 | 10.33 | 4 | 152053 | 38 | 70776349 |
Right ventricular failure | 11.24 | 10.33 | 19 | 152038 | 22255 | 70754132 |
Osteoporosis | 11.24 | 10.33 | 157 | 151900 | 48750 | 70727637 |
Hyperthyroidism | 11.23 | 10.33 | 16 | 152041 | 20075 | 70756312 |
Blood pressure diastolic abnormal | 11.23 | 10.33 | 10 | 152047 | 15494 | 70760893 |
Tri-iodothyronine free decreased | 11.22 | 10.33 | 8 | 152049 | 365 | 70776022 |
Inflammatory marker increased | 11.21 | 10.33 | 3 | 152054 | 9271 | 70767116 |
Contusion | 11.19 | 10.33 | 200 | 151857 | 127836 | 70648551 |
Pulmonary fibrosis | 11.14 | 10.33 | 37 | 152020 | 34273 | 70742114 |
Urinary incontinence | 11.05 | 10.33 | 127 | 151930 | 37715 | 70738672 |
Derealisation | 11.04 | 10.33 | 15 | 152042 | 1521 | 70774866 |
Mental impairment | 11.01 | 10.33 | 69 | 151988 | 17186 | 70759201 |
Visuospatial deficit | 11.00 | 10.33 | 4 | 152053 | 41 | 70776346 |
Petechiae | 10.98 | 10.33 | 15 | 152042 | 19157 | 70757230 |
Staphylococcal bacteraemia | 10.97 | 10.33 | 5 | 152052 | 11077 | 70765310 |
Blood uric acid increased | 10.95 | 10.33 | 3 | 152054 | 9126 | 70767261 |
Hyperlipidaemia | 10.90 | 10.33 | 88 | 151969 | 23775 | 70752612 |
Gastritis erosive | 10.89 | 10.33 | 4 | 152053 | 10091 | 70766296 |
Energy increased | 10.86 | 10.33 | 21 | 152036 | 2863 | 70773524 |
Blood urea increased | 10.85 | 10.33 | 56 | 152001 | 45853 | 70730534 |
Reactive psychosis | 10.84 | 10.33 | 3 | 152054 | 11 | 70776376 |
Secondary immunodeficiency | 10.84 | 10.33 | 21 | 152036 | 2868 | 70773519 |
Galactorrhoea | 10.82 | 10.33 | 23 | 152034 | 3355 | 70773032 |
Family stress | 10.82 | 10.33 | 10 | 152047 | 662 | 70775725 |
Angioedema | 10.81 | 10.33 | 91 | 151966 | 66519 | 70709868 |
Hypertension | 10.80 | 10.33 | 755 | 151302 | 295278 | 70481109 |
Heparin-induced thrombocytopenia | 10.78 | 10.33 | 3 | 152054 | 9034 | 70767353 |
Blood parathyroid hormone decreased | 10.76 | 10.33 | 3 | 152054 | 9021 | 70767366 |
Pulmonary mass | 10.74 | 10.33 | 25 | 152032 | 26008 | 70750379 |
Erysipelas | 10.59 | 10.33 | 4 | 152053 | 9920 | 70766467 |
Sputum discoloured | 10.58 | 10.33 | 73 | 151984 | 18778 | 70757609 |
Tooth fracture | 10.56 | 10.33 | 48 | 152009 | 10579 | 70765808 |
Cachexia | 10.55 | 10.33 | 4 | 152053 | 9896 | 70766491 |
Red blood cell sedimentation rate increased | 10.54 | 10.33 | 128 | 151929 | 38514 | 70737873 |
Acute pulmonary oedema | 10.52 | 10.33 | 8 | 152049 | 13404 | 70762983 |
Feeling guilty | 10.48 | 10.33 | 11 | 152046 | 850 | 70775537 |
Myoglobinuria | 10.47 | 10.33 | 12 | 152045 | 1023 | 70775364 |
Change in sustained attention | 10.45 | 10.33 | 3 | 152054 | 13 | 70776374 |
Tic | 10.42 | 10.33 | 20 | 152037 | 2713 | 70773674 |
Multiple fractures | 10.34 | 10.33 | 35 | 152022 | 6730 | 70769657 |
None
Source | Code | Description |
---|---|---|
ATC | A08AA62 | ALIMENTARY TRACT AND METABOLISM ANTIOBESITY PREPARATIONS, EXCL. DIET PRODUCTS ANTIOBESITY PREPARATIONS, EXCL. DIET PRODUCTS Centrally acting antiobesity products |
ATC | N06AX12 | NERVOUS SYSTEM PSYCHOANALEPTICS ANTIDEPRESSANTS Other antidepressants |
FDA MoA | N0000000102 | Norepinephrine Uptake Inhibitors |
FDA MoA | N0000000114 | Dopamine Uptake Inhibitors |
FDA PE | N0000009282 | Increased Dopamine Activity |
FDA PE | N0000009456 | Increased Norepinephrine Activity |
CHEBI has role | CHEBI:35469 | antidepressants |
CHEBI has role | CHEBI:35703 | Xenobiotic |
CHEBI has role | CHEBI:78298 | environmental contaminants |
FDA EPC | N0000180855 | Aminoketone |
MeSH PA | D000928 | Antidepressive Agents |
MeSH PA | D018687 | Antidepressive Agents, Second-Generation |
MeSH PA | D002491 | Central Nervous System Agents |
MeSH PA | D065690 | Cytochrome P-450 CYP2D6 Inhibitors |
MeSH PA | D065607 | Cytochrome P-450 Enzyme Inhibitors |
MeSH PA | D015259 | Dopamine Agents |
MeSH PA | D018765 | Dopamine Uptake Inhibitors |
MeSH PA | D004791 | Enzyme Inhibitors |
MeSH PA | D049990 | Membrane Transport Modulators |
MeSH PA | D065606 | Metabolic Side Effects of Drugs and Substances |
MeSH PA | D018377 | Neurotransmitter Agents |
MeSH PA | D014179 | Neurotransmitter Uptake Inhibitors |
MeSH PA | D011619 | Psychotropic Drugs |
MeSH PA | D000077444 | Smoking Cessation Agents |
Disease | Relation | SNOMED_ID | DOID |
---|---|---|---|
Depressive disorder | indication | 35489007 | |
Nicotine dependence | indication | 56294008 | DOID:0050742 |
Seasonal affective disorder | indication | 247803002 | |
Major depressive disorder | indication | 370143000 | |
Smoking cessation assistance | indication | 384742004 | |
Obesity | indication | 414916001 | DOID:9970 |
Bipolar affective disorder, current episode depression | off-label use | 191627008 | DOID:3312 |
Attention deficit hyperactivity disorder | off-label use | 406506008 | |
Suicidal thoughts | contraindication | 6471006 | |
Alcoholism | contraindication | 7200002 | |
Mood swings | contraindication | 18963009 | |
Lowered convulsive threshold | contraindication | 19260006 | |
Cirrhosis of liver | contraindication | 19943007 | DOID:5082 |
Myocardial infarction | contraindication | 22298006 | DOID:5844 |
Feeling agitated | contraindication | 24199005 | |
Hypertensive disorder | contraindication | 38341003 | DOID:10763 |
Anorexia nervosa | contraindication | 56882008 | DOID:8689 |
Hepatic failure | contraindication | 59927004 | |
Psychotic disorder | contraindication | 69322001 | |
Opioid dependence | contraindication | 75544000 | DOID:2559 |
Bulimia nervosa | contraindication | 78004001 | |
Hostile behavior | contraindication | 79351003 | |
Injury of head | contraindication | 82271004 | |
Weight loss | contraindication | 89362005 | |
Kidney disease | contraindication | 90708001 | DOID:557 |
Secondary malignant neoplasm of cerebrum | contraindication | 94248000 | |
Neoplasm of central nervous system | contraindication | 126951006 | DOID:3620 |
Seizure disorder | contraindication | 128613002 | |
Bipolar affective disorder, current episode manic | contraindication | 191618007 | |
Disease of liver | contraindication | 235856003 | DOID:409 |
Diabetic - poor control | contraindication | 268519009 | |
Alcohol withdrawal-induced convulsion | contraindication | 308742005 | |
Panic disorder | contraindication | 371631005 | DOID:594 |
Sedative Drug Dependence | contraindication | ||
Seizure due to Abrupt Benzodiazepine Withdrawal | contraindication | ||
Stimulant Drug Dependence | contraindication |
None
None
Dissociation level | Dissociation constant | Type (acidic/basic) |
---|---|---|
pKa1 | 7.87 | Basic |
Formulation strength | Trade name | Applicant | Application number | Approval date | Type | Dose form | Route | Patent number | Patent expiration date | Patent use |
---|---|---|---|---|---|---|---|---|---|---|
90MG;8MG | CONTRAVE | NALPROPION | N200063 | Sept. 10, 2014 | RX | TABLET, EXTENDED RELEASE | ORAL | 11278544 | April 21, 2024 | FOR CHRONIC WEIGHT MANAGEMENT FOR TREATING OVERWEIGHT OR OBESITY |
90MG;8MG | CONTRAVE | NALPROPION | N200063 | Sept. 10, 2014 | RX | TABLET, EXTENDED RELEASE | ORAL | 7462626 | July 20, 2024 | FOR CHRONIC WEIGHT MANAGEMENT FOR TREATING OVERWEIGHT OR OBESITY |
90MG;8MG | CONTRAVE | NALPROPION | N200063 | Sept. 10, 2014 | RX | TABLET, EXTENDED RELEASE | ORAL | 8815889 | July 20, 2024 | FOR EFFECT ON BLOOD GLUCOSE PARAMETERS IN PATIENTS WITH INSULIN RESISTANCE |
174MG | APLENZIN | BAUSCH | N022108 | April 23, 2008 | RX | TABLET, EXTENDED RELEASE | ORAL | 7569610 | June 27, 2026 | TREATMENT OF MAJOR DEPRESSIVE DISORDER BY DOSING AT INTERVALS OF 24 HOURS |
348MG | APLENZIN | BAUSCH | N022108 | April 23, 2008 | RX | TABLET, EXTENDED RELEASE | ORAL | 7569610 | June 27, 2026 | TREATMENT OF MAJOR DEPRESSIVE DISORDER BY DOSING AT INTERVALS OF 24 HOURS |
522MG | APLENZIN | BAUSCH | N022108 | April 23, 2008 | RX | TABLET, EXTENDED RELEASE | ORAL | 7569610 | June 27, 2026 | TREATMENT OF MAJOR DEPRESSIVE DISORDER BY DOSING AT INTERVALS OF 24 HOURS |
90MG;8MG | CONTRAVE | NALPROPION | N200063 | Sept. 10, 2014 | RX | TABLET, EXTENDED RELEASE | ORAL | 9107837 | June 4, 2027 | USE OF NALTREXONE AND BUPROPION IN EXTENDED-RELEASE FORM FOR CHRONIC WEIGHT MANAGEMENT FOR TREATING OVERWEIGHT OR OBESITY |
90MG;8MG | CONTRAVE | NALPROPION | N200063 | Sept. 10, 2014 | RX | TABLET, EXTENDED RELEASE | ORAL | 10307376 | Nov. 8, 2027 | USE OF NALTREXONE AND BUPROPION BASED ON AN ESCALATING DOSE SCHEDULE |
90MG;8MG | CONTRAVE | NALPROPION | N200063 | Sept. 10, 2014 | RX | TABLET, EXTENDED RELEASE | ORAL | 8318788 | Nov. 8, 2027 | USE OF NALTREXONE AND BUPROPION IN A LAYERED FORMULATION FOR CHRONIC WEIGHT MANAGEMENT FOR AFFECTING WEIGHT LOSS |
90MG;8MG | CONTRAVE | NALPROPION | N200063 | Sept. 10, 2014 | RX | TABLET, EXTENDED RELEASE | ORAL | 8722085 | Nov. 8, 2027 | USE OF NALTREXONE AND BUPROPION BASED ON AN ESCALATING DOSE SCHEDULE |
90MG;8MG | CONTRAVE | NALPROPION | N200063 | Sept. 10, 2014 | RX | TABLET, EXTENDED RELEASE | ORAL | 9125868 | Nov. 8, 2027 | USE OF NALTREXONE AND BUPROPION BASED ON AN ESCALATING DOSE SCHEDULE |
90MG;8MG | CONTRAVE | NALPROPION | N200063 | Sept. 10, 2014 | RX | TABLET, EXTENDED RELEASE | ORAL | 11324741 | May 29, 2029 | FOR CHRONIC WEIGHT MANAGEMENT FOR TREATING OVERWEIGHT OR OBESITY |
90MG;8MG | CONTRAVE | NALPROPION | N200063 | Sept. 10, 2014 | RX | TABLET, EXTENDED RELEASE | ORAL | 8916195 | Feb. 2, 2030 | USE OF NALTREXONE AND BUPROPION IN EXTENDED-RELEASE FORM FOR CHRONIC WEIGHT MANAGEMENT FOR TREATING OVERWEIGHT OR OBESITY |
90MG;8MG | CONTRAVE | NALPROPION | N200063 | Sept. 10, 2014 | RX | TABLET, EXTENDED RELEASE | ORAL | 11033543 | Jan. 10, 2031 | FOR CHRONIC WEIGHT MANAGEMENT FOR TREATING OVERWEIGHT OR OBESITY |
90MG;8MG | CONTRAVE | NALPROPION | N200063 | Sept. 10, 2014 | RX | TABLET, EXTENDED RELEASE | ORAL | 9248123 | Jan. 13, 2032 | USE OF NALTREXONE AND BUPROPION FOR CHRONIC WEIGHT MANAGEMENT FOR TREATING OVERWEIGHT OR OBESITY IN PATIENTS WITH MAJOR DEPRESSIVE DISORDER |
90MG;8MG | CONTRAVE | NALPROPION | N200063 | Sept. 10, 2014 | RX | TABLET, EXTENDED RELEASE | ORAL | 10403170 | June 5, 2033 | FOR CHRONIC WEIGHT MANAGEMENT FOR TREATING OVERWEIGHT OR OBESITY |
90MG;8MG | CONTRAVE | NALPROPION | N200063 | Sept. 10, 2014 | RX | TABLET, EXTENDED RELEASE | ORAL | 11139056 | June 5, 2033 | FOR CHRONIC WEIGHT MANAGEMENT FOR TREATING OVERWEIGHT OR OBESITY |
90MG;8MG | CONTRAVE | NALPROPION | N200063 | Sept. 10, 2014 | RX | TABLET, EXTENDED RELEASE | ORAL | 9633575 | June 25, 2033 | FOR CHRONIC WEIGHT MANAGEMENT FOR TREATING OVERWEIGHT OR OBESITY |
105MG;45MG | AUVELITY | AXSOME | N215430 | Aug. 18, 2022 | RX | TABLET, EXTENDED RELEASE | ORAL | 8569328 | Oct. 29, 2033 | DEXTROMETHORPHAN AND BUPROPION IN COMBINATION TO TREAT MAJOR DEPRESSIVE DISORDER |
90MG;8MG | CONTRAVE | NALPROPION | N200063 | Sept. 10, 2014 | RX | TABLET, EXTENDED RELEASE | ORAL | 10231964 | July 2, 2034 | FOR CHRONIC WEIGHT MANAGEMENT FOR TREATING OVERWEIGHT OR OBESITY |
90MG;8MG | CONTRAVE | NALPROPION | N200063 | Sept. 10, 2014 | RX | TABLET, EXTENDED RELEASE | ORAL | 10828294 | July 2, 2034 | FOR CHRONIC WEIGHT MANAGEMENT FOR TREATING OVERWEIGHT OR OBESITY |
90MG;8MG | CONTRAVE | NALPROPION | N200063 | Sept. 10, 2014 | RX | TABLET, EXTENDED RELEASE | ORAL | 10835527 | July 2, 2034 | FOR CHRONIC WEIGHT MANAGEMENT FOR TREATING OVERWEIGHT OR OBESITY |
105MG;45MG | AUVELITY | AXSOME | N215430 | Aug. 18, 2022 | RX | TABLET, EXTENDED RELEASE | ORAL | 10058518 | Nov. 5, 2034 | DEXTROMETHORPHAN AND BUPROPION IN COMBINATION TO TREAT MAJOR DEPRESSIVE DISORDER |
105MG;45MG | AUVELITY | AXSOME | N215430 | Aug. 18, 2022 | RX | TABLET, EXTENDED RELEASE | ORAL | 10064857 | Nov. 5, 2034 | DEXTROMETHORPHAN AND BUPROPION IN COMBINATION TO TREAT MAJOR DEPRESSIVE DISORDER |
105MG;45MG | AUVELITY | AXSOME | N215430 | Aug. 18, 2022 | RX | TABLET, EXTENDED RELEASE | ORAL | 10080727 | Nov. 5, 2034 | DEXTROMETHORPHAN AND BUPROPION IN COMBINATION TO TREAT MAJOR DEPRESSIVE DISORDER |
105MG;45MG | AUVELITY | AXSOME | N215430 | Aug. 18, 2022 | RX | TABLET, EXTENDED RELEASE | ORAL | 10092560 | Nov. 5, 2034 | DEXTROMETHORPHAN AND BUPROPION IN COMBINATION TO TREAT MAJOR DEPRESSIVE DISORDER |
105MG;45MG | AUVELITY | AXSOME | N215430 | Aug. 18, 2022 | RX | TABLET, EXTENDED RELEASE | ORAL | 10092561 | Nov. 5, 2034 | DEXTROMETHORPHAN AND BUPROPION IN COMBINATION TO TREAT MAJOR DEPRESSIVE DISORDER |
105MG;45MG | AUVELITY | AXSOME | N215430 | Aug. 18, 2022 | RX | TABLET, EXTENDED RELEASE | ORAL | 10105327 | Nov. 5, 2034 | DEXTROMETHORPHAN AND BUPROPION IN COMBINATION TO TREAT MAJOR DEPRESSIVE DISORDER |
105MG;45MG | AUVELITY | AXSOME | N215430 | Aug. 18, 2022 | RX | TABLET, EXTENDED RELEASE | ORAL | 10105361 | Nov. 5, 2034 | DEXTROMETHORPHAN AND BUPROPION IN COMBINATION TO TREAT MAJOR DEPRESSIVE DISORDER |
105MG;45MG | AUVELITY | AXSOME | N215430 | Aug. 18, 2022 | RX | TABLET, EXTENDED RELEASE | ORAL | 10251879 | Nov. 5, 2034 | DEXTROMETHORPHAN AND BUPROPION IN COMBINATION TO TREAT MAJOR DEPRESSIVE DISORDER |
105MG;45MG | AUVELITY | AXSOME | N215430 | Aug. 18, 2022 | RX | TABLET, EXTENDED RELEASE | ORAL | 10463634 | Nov. 5, 2034 | DEXTROMETHORPHAN AND BUPROPION IN COMBINATION TO TREAT MAJOR DEPRESSIVE DISORDER |
105MG;45MG | AUVELITY | AXSOME | N215430 | Aug. 18, 2022 | RX | TABLET, EXTENDED RELEASE | ORAL | 10512643 | Nov. 5, 2034 | DEXTROMETHORPHAN AND BUPROPION IN COMBINATION TO TREAT MAJOR DEPRESSIVE DISORDER |
105MG;45MG | AUVELITY | AXSOME | N215430 | Aug. 18, 2022 | RX | TABLET, EXTENDED RELEASE | ORAL | 10548857 | Nov. 5, 2034 | DEXTROMETHORPHAN AND BUPROPION IN COMBINATION TO TREAT MAJOR DEPRESSIVE DISORDER |
105MG;45MG | AUVELITY | AXSOME | N215430 | Aug. 18, 2022 | RX | TABLET, EXTENDED RELEASE | ORAL | 10596167 | Nov. 5, 2034 | DEXTROMETHORPHAN AND BUPROPION IN COMBINATION TO TREAT MAJOR DEPRESSIVE DISORDER |
105MG;45MG | AUVELITY | AXSOME | N215430 | Aug. 18, 2022 | RX | TABLET, EXTENDED RELEASE | ORAL | 10772850 | Nov. 5, 2034 | DEXTROMETHORPHAN AND BUPROPION IN COMBINATION TO TREAT MAJOR DEPRESSIVE DISORDER |
105MG;45MG | AUVELITY | AXSOME | N215430 | Aug. 18, 2022 | RX | TABLET, EXTENDED RELEASE | ORAL | 10786469 | Nov. 5, 2034 | DEXTROMETHORPHAN AND BUPROPION IN COMBINATION TO TREAT MAJOR DEPRESSIVE DISORDER |
105MG;45MG | AUVELITY | AXSOME | N215430 | Aug. 18, 2022 | RX | TABLET, EXTENDED RELEASE | ORAL | 10786496 | Nov. 5, 2034 | DEXTROMETHORPHAN AND BUPROPION IN COMBINATION TO TREAT MAJOR DEPRESSIVE DISORDER |
105MG;45MG | AUVELITY | AXSOME | N215430 | Aug. 18, 2022 | RX | TABLET, EXTENDED RELEASE | ORAL | 10799497 | Nov. 5, 2034 | DEXTROMETHORPHAN AND BUPROPION IN COMBINATION TO TREAT MAJOR DEPRESSIVE DISORDER |
105MG;45MG | AUVELITY | AXSOME | N215430 | Aug. 18, 2022 | RX | TABLET, EXTENDED RELEASE | ORAL | 10806710 | Nov. 5, 2034 | DEXTROMETHORPHAN AND BUPROPION IN COMBINATION TO TREAT MAJOR DEPRESSIVE DISORDER |
105MG;45MG | AUVELITY | AXSOME | N215430 | Aug. 18, 2022 | RX | TABLET, EXTENDED RELEASE | ORAL | 10864209 | Nov. 5, 2034 | DEXTROMETHORPHAN AND BUPROPION IN COMBINATION TO TREAT MAJOR DEPRESSIVE DISORDER |
105MG;45MG | AUVELITY | AXSOME | N215430 | Aug. 18, 2022 | RX | TABLET, EXTENDED RELEASE | ORAL | 10874663 | Nov. 5, 2034 | DEXTROMETHORPHAN AND BUPROPION IN COMBINATION TO TREAT MAJOR DEPRESSIVE DISORDER |
105MG;45MG | AUVELITY | AXSOME | N215430 | Aug. 18, 2022 | RX | TABLET, EXTENDED RELEASE | ORAL | 10874664 | Nov. 5, 2034 | DEXTROMETHORPHAN AND BUPROPION IN COMBINATION TO TREAT MAJOR DEPRESSIVE DISORDER |
105MG;45MG | AUVELITY | AXSOME | N215430 | Aug. 18, 2022 | RX | TABLET, EXTENDED RELEASE | ORAL | 10874665 | Nov. 5, 2034 | DEXTROMETHORPHAN AND BUPROPION IN COMBINATION TO TREAT MAJOR DEPRESSIVE DISORDER |
105MG;45MG | AUVELITY | AXSOME | N215430 | Aug. 18, 2022 | RX | TABLET, EXTENDED RELEASE | ORAL | 10881624 | Nov. 5, 2034 | DEXTROMETHORPHAN AND BUPROPION IN COMBINATION TO TREAT MAJOR DEPRESSIVE DISORDER |
105MG;45MG | AUVELITY | AXSOME | N215430 | Aug. 18, 2022 | RX | TABLET, EXTENDED RELEASE | ORAL | 10881657 | Nov. 5, 2034 | DEXTROMETHORPHAN AND BUPROPION IN COMBINATION TO TREAT MAJOR DEPRESSIVE DISORDER |
105MG;45MG | AUVELITY | AXSOME | N215430 | Aug. 18, 2022 | RX | TABLET, EXTENDED RELEASE | ORAL | 10894046 | Nov. 5, 2034 | DEXTROMETHORPHAN AND BUPROPION IN COMBINATION TO TREAT MAJOR DEPRESSIVE DISORDER |
105MG;45MG | AUVELITY | AXSOME | N215430 | Aug. 18, 2022 | RX | TABLET, EXTENDED RELEASE | ORAL | 10894047 | Nov. 5, 2034 | DEXTROMETHORPHAN AND BUPROPION IN COMBINATION TO TREAT MAJOR DEPRESSIVE DISORDER |
105MG;45MG | AUVELITY | AXSOME | N215430 | Aug. 18, 2022 | RX | TABLET, EXTENDED RELEASE | ORAL | 10898453 | Nov. 5, 2034 | DEXTROMETHORPHAN AND BUPROPION IN COMBINATION TO TREAT MAJOR DEPRESSIVE DISORDER |
105MG;45MG | AUVELITY | AXSOME | N215430 | Aug. 18, 2022 | RX | TABLET, EXTENDED RELEASE | ORAL | 10933034 | Nov. 5, 2034 | DEXTROMETHORPHAN AND BUPROPION IN COMBINATION TO TREAT MAJOR DEPRESSIVE DISORDER |
105MG;45MG | AUVELITY | AXSOME | N215430 | Aug. 18, 2022 | RX | TABLET, EXTENDED RELEASE | ORAL | 10945973 | Nov. 5, 2034 | DEXTROMETHORPHAN AND BUPROPION IN COMBINATION TO TREAT MAJOR DEPRESSIVE DISORDER |
105MG;45MG | AUVELITY | AXSOME | N215430 | Aug. 18, 2022 | RX | TABLET, EXTENDED RELEASE | ORAL | 10966941 | Nov. 5, 2034 | DEXTROMETHORPHAN AND BUPROPION IN COMBINATION TO TREAT MAJOR DEPRESSIVE DISORDER |
105MG;45MG | AUVELITY | AXSOME | N215430 | Aug. 18, 2022 | RX | TABLET, EXTENDED RELEASE | ORAL | 10966974 | Nov. 5, 2034 | DEXTROMETHORPHAN AND BUPROPION IN COMBINATION TO TREAT MAJOR DEPRESSIVE DISORDER |
105MG;45MG | AUVELITY | AXSOME | N215430 | Aug. 18, 2022 | RX | TABLET, EXTENDED RELEASE | ORAL | 11020389 | Nov. 5, 2034 | DEXTROMETHORPHAN AND BUPROPION IN COMBINATION TO TREAT MAJOR DEPRESSIVE DISORDER |
105MG;45MG | AUVELITY | AXSOME | N215430 | Aug. 18, 2022 | RX | TABLET, EXTENDED RELEASE | ORAL | 11058648 | Nov. 5, 2034 | DEXTROMETHORPHAN AND BUPROPION IN COMBINATION TO TREAT MAJOR DEPRESSIVE DISORDER |
105MG;45MG | AUVELITY | AXSOME | N215430 | Aug. 18, 2022 | RX | TABLET, EXTENDED RELEASE | ORAL | 11090300 | Nov. 5, 2034 | DEXTROMETHORPHAN AND BUPROPION IN COMBINATION TO TREAT MAJOR DEPRESSIVE DISORDER |
105MG;45MG | AUVELITY | AXSOME | N215430 | Aug. 18, 2022 | RX | TABLET, EXTENDED RELEASE | ORAL | 11096937 | Nov. 5, 2034 | DEXTROMETHORPHAN AND BUPROPION IN COMBINATION TO TREAT MAJOR DEPRESSIVE DISORDER |
105MG;45MG | AUVELITY | AXSOME | N215430 | Aug. 18, 2022 | RX | TABLET, EXTENDED RELEASE | ORAL | 11123343 | Nov. 5, 2034 | DEXTROMETHORPHAN AND BUPROPION IN COMBINATION TO TREAT MAJOR DEPRESSIVE DISORDER |
105MG;45MG | AUVELITY | AXSOME | N215430 | Aug. 18, 2022 | RX | TABLET, EXTENDED RELEASE | ORAL | 11129826 | Nov. 5, 2034 | DEXTROMETHORPHAN AND BUPROPION IN COMBINATION TO TREAT MAJOR DEPRESSIVE DISORDER |
105MG;45MG | AUVELITY | AXSOME | N215430 | Aug. 18, 2022 | RX | TABLET, EXTENDED RELEASE | ORAL | 11141388 | Nov. 5, 2034 | DEXTROMETHORPHAN AND BUPROPION IN COMBINATION TO TREAT MAJOR DEPRESSIVE DISORDER |
105MG;45MG | AUVELITY | AXSOME | N215430 | Aug. 18, 2022 | RX | TABLET, EXTENDED RELEASE | ORAL | 11141416 | Nov. 5, 2034 | DEXTROMETHORPHAN AND BUPROPION IN COMBINATION TO TREAT MAJOR DEPRESSIVE DISORDER |
105MG;45MG | AUVELITY | AXSOME | N215430 | Aug. 18, 2022 | RX | TABLET, EXTENDED RELEASE | ORAL | 11147808 | Nov. 5, 2034 | DEXTROMETHORPHAN AND BUPROPION IN COMBINATION TO TREAT MAJOR DEPRESSIVE DISORDER |
105MG;45MG | AUVELITY | AXSOME | N215430 | Aug. 18, 2022 | RX | TABLET, EXTENDED RELEASE | ORAL | 11185515 | Nov. 5, 2034 | DEXTROMETHORPHAN AND BUPROPION IN COMBINATION TO TREAT MAJOR DEPRESSIVE DISORDER |
105MG;45MG | AUVELITY | AXSOME | N215430 | Aug. 18, 2022 | RX | TABLET, EXTENDED RELEASE | ORAL | 11191739 | Nov. 5, 2034 | DEXTROMETHORPHAN AND BUPROPION IN COMBINATION TO TREAT MAJOR DEPRESSIVE DISORDER |
105MG;45MG | AUVELITY | AXSOME | N215430 | Aug. 18, 2022 | RX | TABLET, EXTENDED RELEASE | ORAL | 11197839 | Nov. 5, 2034 | DEXTROMETHORPHAN AND BUPROPION IN COMBINATION TO TREAT MAJOR DEPRESSIVE DISORDER |
105MG;45MG | AUVELITY | AXSOME | N215430 | Aug. 18, 2022 | RX | TABLET, EXTENDED RELEASE | ORAL | 11207281 | Nov. 5, 2034 | DEXTROMETHORPHAN AND BUPROPION IN COMBINATION TO TREAT MAJOR DEPRESSIVE DISORDER |
105MG;45MG | AUVELITY | AXSOME | N215430 | Aug. 18, 2022 | RX | TABLET, EXTENDED RELEASE | ORAL | 11213521 | Nov. 5, 2034 | DEXTROMETHORPHAN AND BUPROPION IN COMBINATION TO TREAT MAJOR DEPRESSIVE DISORDER |
105MG;45MG | AUVELITY | AXSOME | N215430 | Aug. 18, 2022 | RX | TABLET, EXTENDED RELEASE | ORAL | 11229640 | Nov. 5, 2034 | DEXTROMETHORPHAN AND BUPROPION IN COMBINATION TO TREAT MAJOR DEPRESSIVE DISORDER |
105MG;45MG | AUVELITY | AXSOME | N215430 | Aug. 18, 2022 | RX | TABLET, EXTENDED RELEASE | ORAL | 11234946 | Nov. 5, 2034 | DEXTROMETHORPHAN AND BUPROPION IN COMBINATION TO TREAT MAJOR DEPRESSIVE DISORDER |
105MG;45MG | AUVELITY | AXSOME | N215430 | Aug. 18, 2022 | RX | TABLET, EXTENDED RELEASE | ORAL | 11253491 | Nov. 5, 2034 | DEXTROMETHORPHAN AND BUPROPION IN COMBINATION TO TREAT MAJOR DEPRESSIVE DISORDER |
105MG;45MG | AUVELITY | AXSOME | N215430 | Aug. 18, 2022 | RX | TABLET, EXTENDED RELEASE | ORAL | 11253492 | Nov. 5, 2034 | DEXTROMETHORPHAN AND BUPROPION IN COMBINATION TO TREAT MAJOR DEPRESSIVE DISORDER |
105MG;45MG | AUVELITY | AXSOME | N215430 | Aug. 18, 2022 | RX | TABLET, EXTENDED RELEASE | ORAL | 11273133 | Nov. 5, 2034 | DEXTROMETHORPHAN AND BUPROPION IN COMBINATION TO TREAT MAJOR DEPRESSIVE DISORDER |
105MG;45MG | AUVELITY | AXSOME | N215430 | Aug. 18, 2022 | RX | TABLET, EXTENDED RELEASE | ORAL | 11273134 | Nov. 5, 2034 | DEXTROMETHORPHAN AND BUPROPION IN COMBINATION TO TREAT MAJOR DEPRESSIVE DISORDER |
105MG;45MG | AUVELITY | AXSOME | N215430 | Aug. 18, 2022 | RX | TABLET, EXTENDED RELEASE | ORAL | 11285118 | Nov. 5, 2034 | DEXTROMETHORPHAN AND BUPROPION IN COMBINATION TO TREAT MAJOR DEPRESSIVE DISORDER |
105MG;45MG | AUVELITY | AXSOME | N215430 | Aug. 18, 2022 | RX | TABLET, EXTENDED RELEASE | ORAL | 11285146 | Nov. 5, 2034 | DEXTROMETHORPHAN AND BUPROPION IN COMBINATION TO TREAT MAJOR DEPRESSIVE DISORDER |
105MG;45MG | AUVELITY | AXSOME | N215430 | Aug. 18, 2022 | RX | TABLET, EXTENDED RELEASE | ORAL | 11291638 | Nov. 5, 2034 | DEXTROMETHORPHAN AND BUPROPION IN COMBINATION TO TREAT MAJOR DEPRESSIVE DISORDER |
105MG;45MG | AUVELITY | AXSOME | N215430 | Aug. 18, 2022 | RX | TABLET, EXTENDED RELEASE | ORAL | 11291665 | Nov. 5, 2034 | DEXTROMETHORPHAN AND BUPROPION IN COMBINATION TO TREAT MAJOR DEPRESSIVE DISORDER |
105MG;45MG | AUVELITY | AXSOME | N215430 | Aug. 18, 2022 | RX | TABLET, EXTENDED RELEASE | ORAL | 11298351 | Nov. 5, 2034 | DEXTROMETHORPHAN AND BUPROPION IN COMBINATION TO TREAT MAJOR DEPRESSIVE DISORDER |
105MG;45MG | AUVELITY | AXSOME | N215430 | Aug. 18, 2022 | RX | TABLET, EXTENDED RELEASE | ORAL | 11298352 | Nov. 5, 2034 | DEXTROMETHORPHAN AND BUPROPION IN COMBINATION TO TREAT MAJOR DEPRESSIVE DISORDER |
105MG;45MG | AUVELITY | AXSOME | N215430 | Aug. 18, 2022 | RX | TABLET, EXTENDED RELEASE | ORAL | 11311534 | Nov. 5, 2034 | DEXTROMETHORPHAN AND BUPROPION IN COMBINATION TO TREAT MAJOR DEPRESSIVE DISORDER |
105MG;45MG | AUVELITY | AXSOME | N215430 | Aug. 18, 2022 | RX | TABLET, EXTENDED RELEASE | ORAL | 11344544 | Nov. 5, 2034 | DEXTROMETHORPHAN AND BUPROPION IN COMBINATION TO TREAT MAJOR DEPRESSIVE DISORDER |
105MG;45MG | AUVELITY | AXSOME | N215430 | Aug. 18, 2022 | RX | TABLET, EXTENDED RELEASE | ORAL | 11357744 | Nov. 5, 2034 | DEXTROMETHORPHAN AND BUPROPION IN COMBINATION TO TREAT MAJOR DEPRESSIVE DISORDER |
105MG;45MG | AUVELITY | AXSOME | N215430 | Aug. 18, 2022 | RX | TABLET, EXTENDED RELEASE | ORAL | 11364233 | Nov. 5, 2034 | DEXTROMETHORPHAN AND BUPROPION IN COMBINATION TO TREAT MAJOR DEPRESSIVE DISORDER |
105MG;45MG | AUVELITY | AXSOME | N215430 | Aug. 18, 2022 | RX | TABLET, EXTENDED RELEASE | ORAL | 11382874 | Nov. 5, 2034 | DEXTROMETHORPHAN AND BUPROPION IN COMBINATION TO TREAT MAJOR DEPRESSIVE DISORDER |
105MG;45MG | AUVELITY | AXSOME | N215430 | Aug. 18, 2022 | RX | TABLET, EXTENDED RELEASE | ORAL | 11419867 | Nov. 5, 2034 | DEXTROMETHORPHAN AND BUPROPION IN COMBINATION TO TREAT MAJOR DEPRESSIVE DISORDER |
105MG;45MG | AUVELITY | AXSOME | N215430 | Aug. 18, 2022 | RX | TABLET, EXTENDED RELEASE | ORAL | 11426370 | Nov. 5, 2034 | DEXTROMETHORPHAN AND BUPROPION IN COMBINATION TO TREAT MAJOR DEPRESSIVE DISORDER |
105MG;45MG | AUVELITY | AXSOME | N215430 | Aug. 18, 2022 | RX | TABLET, EXTENDED RELEASE | ORAL | 11426401 | Nov. 5, 2034 | DEXTROMETHORPHAN AND BUPROPION IN COMBINATION TO TREAT MAJOR DEPRESSIVE DISORDER |
105MG;45MG | AUVELITY | AXSOME | N215430 | Aug. 18, 2022 | RX | TABLET, EXTENDED RELEASE | ORAL | 11433067 | Nov. 5, 2034 | DEXTROMETHORPHAN AND BUPROPION IN COMBINATION TO TREAT MAJOR DEPRESSIVE DISORDER |
105MG;45MG | AUVELITY | AXSOME | N215430 | Aug. 18, 2022 | RX | TABLET, EXTENDED RELEASE | ORAL | 11439636 | Nov. 5, 2034 | DEXTROMETHORPHAN AND BUPROPION IN COMBINATION TO TREAT MAJOR DEPRESSIVE DISORDER |
105MG;45MG | AUVELITY | AXSOME | N215430 | Aug. 18, 2022 | RX | TABLET, EXTENDED RELEASE | ORAL | 9168234 | Nov. 5, 2034 | DEXTROMETHORPHAN AND BUPROPION IN COMBINATION TO TREAT MAJOR DEPRESSIVE DISORDER |
105MG;45MG | AUVELITY | AXSOME | N215430 | Aug. 18, 2022 | RX | TABLET, EXTENDED RELEASE | ORAL | 9198905 | Nov. 5, 2034 | DEXTROMETHORPHAN AND BUPROPION IN COMBINATION TO TREAT MAJOR DEPRESSIVE DISORDER |
105MG;45MG | AUVELITY | AXSOME | N215430 | Aug. 18, 2022 | RX | TABLET, EXTENDED RELEASE | ORAL | 9205083 | Nov. 5, 2034 | DEXTROMETHORPHAN AND BUPROPION IN COMBINATION TO TREAT MAJOR DEPRESSIVE DISORDER |
105MG;45MG | AUVELITY | AXSOME | N215430 | Aug. 18, 2022 | RX | TABLET, EXTENDED RELEASE | ORAL | 9238032 | Nov. 5, 2034 | DEXTROMETHORPHAN AND BUPROPION IN COMBINATION TO TREAT MAJOR DEPRESSIVE DISORDER |
105MG;45MG | AUVELITY | AXSOME | N215430 | Aug. 18, 2022 | RX | TABLET, EXTENDED RELEASE | ORAL | 9278095 | Nov. 5, 2034 | DEXTROMETHORPHAN AND BUPROPION IN COMBINATION TO TREAT MAJOR DEPRESSIVE DISORDER |
105MG;45MG | AUVELITY | AXSOME | N215430 | Aug. 18, 2022 | RX | TABLET, EXTENDED RELEASE | ORAL | 9314462 | Nov. 5, 2034 | DEXTROMETHORPHAN AND BUPROPION IN COMBINATION TO TREAT MAJOR DEPRESSIVE DISORDER |
105MG;45MG | AUVELITY | AXSOME | N215430 | Aug. 18, 2022 | RX | TABLET, EXTENDED RELEASE | ORAL | 9370513 | Nov. 5, 2034 | DEXTROMETHORPHAN AND BUPROPION IN COMBINATION TO TREAT MAJOR DEPRESSIVE DISORDER |
105MG;45MG | AUVELITY | AXSOME | N215430 | Aug. 18, 2022 | RX | TABLET, EXTENDED RELEASE | ORAL | 9375429 | Nov. 5, 2034 | DEXTROMETHORPHAN AND BUPROPION IN COMBINATION TO TREAT MAJOR DEPRESSIVE DISORDER |
105MG;45MG | AUVELITY | AXSOME | N215430 | Aug. 18, 2022 | RX | TABLET, EXTENDED RELEASE | ORAL | 9408815 | Nov. 5, 2034 | DEXTROMETHORPHAN AND BUPROPION IN COMBINATION TO TREAT MAJOR DEPRESSIVE DISORDER |
105MG;45MG | AUVELITY | AXSOME | N215430 | Aug. 18, 2022 | RX | TABLET, EXTENDED RELEASE | ORAL | 9421176 | Nov. 5, 2034 | DEXTROMETHORPHAN AND BUPROPION IN COMBINATION TO TREAT MAJOR DEPRESSIVE DISORDER |
105MG;45MG | AUVELITY | AXSOME | N215430 | Aug. 18, 2022 | RX | TABLET, EXTENDED RELEASE | ORAL | 9457023 | Nov. 5, 2034 | DEXTROMETHORPHAN AND BUPROPION IN COMBINATION TO TREAT MAJOR DEPRESSIVE DISORDER |
105MG;45MG | AUVELITY | AXSOME | N215430 | Aug. 18, 2022 | RX | TABLET, EXTENDED RELEASE | ORAL | 9457025 | Nov. 5, 2034 | DEXTROMETHORPHAN AND BUPROPION IN COMBINATION TO TREAT MAJOR DEPRESSIVE DISORDER |
105MG;45MG | AUVELITY | AXSOME | N215430 | Aug. 18, 2022 | RX | TABLET, EXTENDED RELEASE | ORAL | 9474731 | Nov. 5, 2034 | DEXTROMETHORPHAN AND BUPROPION IN COMBINATION TO TREAT MAJOR DEPRESSIVE DISORDER |
105MG;45MG | AUVELITY | AXSOME | N215430 | Aug. 18, 2022 | RX | TABLET, EXTENDED RELEASE | ORAL | 9486450 | Nov. 5, 2034 | DEXTROMETHORPHAN AND BUPROPION IN COMBINATION TO TREAT MAJOR DEPRESSIVE DISORDER |
105MG;45MG | AUVELITY | AXSOME | N215430 | Aug. 18, 2022 | RX | TABLET, EXTENDED RELEASE | ORAL | 9700528 | Nov. 5, 2034 | DEXTROMETHORPHAN AND BUPROPION IN COMBINATION TO TREAT MAJOR DEPRESSIVE DISORDER |
105MG;45MG | AUVELITY | AXSOME | N215430 | Aug. 18, 2022 | RX | TABLET, EXTENDED RELEASE | ORAL | 9700553 | Nov. 5, 2034 | DEXTROMETHORPHAN AND BUPROPION IN COMBINATION TO TREAT MAJOR DEPRESSIVE DISORDER |
105MG;45MG | AUVELITY | AXSOME | N215430 | Aug. 18, 2022 | RX | TABLET, EXTENDED RELEASE | ORAL | 9707191 | Nov. 5, 2034 | DEXTROMETHORPHAN AND BUPROPION IN COMBINATION TO TREAT MAJOR DEPRESSIVE DISORDER |
105MG;45MG | AUVELITY | AXSOME | N215430 | Aug. 18, 2022 | RX | TABLET, EXTENDED RELEASE | ORAL | 9763932 | Nov. 5, 2034 | DEXTROMETHORPHAN AND BUPROPION IN COMBINATION TO TREAT MAJOR DEPRESSIVE DISORDER |
105MG;45MG | AUVELITY | AXSOME | N215430 | Aug. 18, 2022 | RX | TABLET, EXTENDED RELEASE | ORAL | 9861595 | Nov. 5, 2034 | DEXTROMETHORPHAN AND BUPROPION IN COMBINATION TO TREAT MAJOR DEPRESSIVE DISORDER |
105MG;45MG | AUVELITY | AXSOME | N215430 | Aug. 18, 2022 | RX | TABLET, EXTENDED RELEASE | ORAL | 9867819 | Nov. 5, 2034 | DEXTROMETHORPHAN AND BUPROPION IN COMBINATION TO TREAT MAJOR DEPRESSIVE DISORDER |
105MG;45MG | AUVELITY | AXSOME | N215430 | Aug. 18, 2022 | RX | TABLET, EXTENDED RELEASE | ORAL | 9968568 | Nov. 5, 2034 | DEXTROMETHORPHAN AND BUPROPION IN COMBINATION TO TREAT MAJOR DEPRESSIVE DISORDER |
105MG;45MG | AUVELITY | AXSOME | N215430 | Aug. 18, 2022 | RX | TABLET, EXTENDED RELEASE | ORAL | 10780066 | Nov. 9, 2034 | DEXTROMETHORPHAN AND BUPROPION IN COMBINATION TO TREAT MAJOR DEPRESSIVE DISORDER |
105MG;45MG | AUVELITY | AXSOME | N215430 | Aug. 18, 2022 | RX | TABLET, EXTENDED RELEASE | ORAL | 10780064 | Jan. 7, 2040 | DEXTROMETHORPHAN AND BUPROPION IN COMBINATION TO TREAT MAJOR DEPRESSIVE DISORDER |
105MG;45MG | AUVELITY | AXSOME | N215430 | Aug. 18, 2022 | RX | TABLET, EXTENDED RELEASE | ORAL | 10925842 | Jan. 7, 2040 | DEXTROMETHORPHAN AND BUPROPION IN COMBINATION TO TREAT MAJOR DEPRESSIVE DISORDER |
105MG;45MG | AUVELITY | AXSOME | N215430 | Aug. 18, 2022 | RX | TABLET, EXTENDED RELEASE | ORAL | 10940124 | Jan. 7, 2040 | DEXTROMETHORPHAN AND BUPROPION IN COMBINATION TO TREAT MAJOR DEPRESSIVE DISORDER |
105MG;45MG | AUVELITY | AXSOME | N215430 | Aug. 18, 2022 | RX | TABLET, EXTENDED RELEASE | ORAL | 10966942 | Jan. 7, 2040 | DEXTROMETHORPHAN AND BUPROPION IN COMBINATION TO TREAT MAJOR DEPRESSIVE DISORDER |
Formulation strength | Trade name | Applicant | Application number | Approval date | Type | Dose form | Route | Exclusivity date | Description |
---|---|---|---|---|---|---|---|---|---|
105MG;45MG | AUVELITY | AXSOME | N215430 | Aug. 18, 2022 | RX | TABLET, EXTENDED RELEASE | ORAL | Aug. 18, 2025 | NEW PRODUCT |
Target | Class | Pharos | UniProt | Action | Type | Activity value (-log[M]) | Mechanism action | Bioact source | MoA source |
---|---|---|---|---|---|---|---|---|---|
Sodium-dependent dopamine transporter | Transporter | INHIBITOR | Kd | 6.28 | WOMBAT-PK | CHEMBL | |||
Sodium-dependent noradrenaline transporter | Transporter | INHIBITOR | Ki | 5.16 | CHEMBL | CHEMBL | |||
Cytochrome P450 2D6 | Enzyme | WOMBAT-PK | |||||||
Neuronal acetylcholine receptor subunit alpha-7 | Ion channel | IC50 | 4.30 | CHEMBL | |||||
Cytochrome P450 2C19 | Enzyme | IC50 | 5.70 | DRUG MATRIX | |||||
Neuronal acetylcholine receptor; alpha3/beta4 | Ion channel | IC50 | 5.74 | CHEMBL | |||||
Sodium-dependent serotonin transporter | Transporter | Kd | 5.04 | WOMBAT-PK | |||||
Neuronal acetylcholine receptor; alpha3/beta2 | Ion channel | IC50 | 6 | CHEMBL | |||||
Alpha-1A adrenergic receptor | GPCR | Ki | 4.80 | PDSP | |||||
Membrane-associated progesterone receptor component 1 | Membrane receptor | Ki | 5.85 | DRUG MATRIX | |||||
Sodium-dependent dopamine transporter | Transporter | IC50 | 5.91 | CHEMBL |
ID | Source |
---|---|
4019645 | VUID |
N0000147738 | NUI |
D00817 | KEGG_DRUG |
31677-93-7 | SECONDARY_CAS_RN |
905818-69-1 | SECONDARY_CAS_RN |
203204 | RXNORM |
4019483 | VANDF |
4019645 | VANDF |
4029878 | VANDF |
C0085208 | UMLSCUI |
CHEBI:3219 | CHEBI |
CHEMBL894 | ChEMBL_ID |
DB01156 | DRUGBANK_ID |
CHEMBL1201735 | ChEMBL_ID |
CHEMBL1698 | ChEMBL_ID |
D016642 | MESH_DESCRIPTOR_UI |
444 | PUBCHEM_CID |
7135 | IUPHAR_LIGAND_ID |
3562 | INN_ID |
01ZG3TPX31 | UNII |
162122 | MMSL |
26259 | MMSL |
31548 | MMSL |
4307 | MMSL |
4319 | MMSL |
d00181 | MMSL |
001512 | NDDF |
004611 | NDDF |
012996 | NDDF |
387564004 | SNOMEDCT_US |
395733003 | SNOMEDCT_US |
431408005 | SNOMEDCT_US |
96199001 | SNOMEDCT_US |
Product | Category | Ingredients | NDC | Form | Quantity | Route | Marketing | Label |
---|---|---|---|---|---|---|---|---|
Bupropion Hydrochloride | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0115-5445 | TABLET, FILM COATED, EXTENDED RELEASE | 200 mg | ORAL | ANDA | 30 sections |
Bupropion Hydrochloride | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0115-6811 | TABLET, FILM COATED, EXTENDED RELEASE | 150 mg | ORAL | ANDA | 30 sections |
Bupropion Hydrochloride | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0115-6811 | TABLET, FILM COATED, EXTENDED RELEASE | 150 mg | ORAL | ANDA | 30 sections |
WELLBUTRINSR | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0173-0135 | TABLET, FILM COATED | 150 mg | ORAL | NDA | 29 sections |
WELLBUTRINSR | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0173-0135 | TABLET, FILM COATED | 150 mg | ORAL | NDA | 29 sections |
WELLBUTRINSR | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0173-0135 | TABLET, FILM COATED | 150 mg | ORAL | NDA | 29 sections |
WELLBUTRINSR | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0173-0722 | TABLET, FILM COATED | 200 mg | ORAL | NDA | 29 sections |
WELLBUTRINSR | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0173-0722 | TABLET, FILM COATED | 200 mg | ORAL | NDA | 29 sections |
WELLBUTRINSR | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0173-0722 | TABLET, FILM COATED | 200 mg | ORAL | NDA | 29 sections |
WELLBUTRINSR | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0173-0947 | TABLET, FILM COATED | 100 mg | ORAL | NDA | 29 sections |
WELLBUTRINSR | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0173-0947 | TABLET, FILM COATED | 100 mg | ORAL | NDA | 29 sections |
WELLBUTRINSR | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0173-0947 | TABLET, FILM COATED | 100 mg | ORAL | NDA | 29 sections |
Bupropion Hydrochloride | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0185-0410 | TABLET, EXTENDED RELEASE | 100 mg | ORAL | ANDA | 29 sections |
Bupropion Hydrochloride | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0185-0410 | TABLET, EXTENDED RELEASE | 100 mg | ORAL | ANDA | 29 sections |
Bupropion Hydrochloride | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0185-0415 | TABLET, EXTENDED RELEASE | 150 mg | ORAL | ANDA | 29 sections |
Bupropion Hydrochloride | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0185-0415 | TABLET, EXTENDED RELEASE | 150 mg | ORAL | ANDA | 29 sections |
Bupropion Hydrochloride | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0185-1111 | TABLET, EXTENDED RELEASE | 200 mg | ORAL | ANDA | 29 sections |
Bupropion Hydrochloride | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0185-1111 | TABLET, EXTENDED RELEASE | 200 mg | ORAL | ANDA | 29 sections |
WELLBUTRINXL | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0187-0730 | TABLET, EXTENDED RELEASE | 150 mg | ORAL | NDA | 28 sections |
WELLBUTRINXL | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0187-0730 | TABLET, EXTENDED RELEASE | 150 mg | ORAL | NDA | 28 sections |
WELLBUTRINXL | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0187-0731 | TABLET, EXTENDED RELEASE | 300 mg | ORAL | NDA | 28 sections |
WELLBUTRINXL | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0187-0731 | TABLET, EXTENDED RELEASE | 300 mg | ORAL | NDA | 28 sections |
Aplenzin | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0187-5810 | TABLET, EXTENDED RELEASE | 174 mg | ORAL | NDA | 29 sections |
Aplenzin | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0187-5810 | TABLET, EXTENDED RELEASE | 174 mg | ORAL | NDA | 29 sections |
Aplenzin | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0187-5811 | TABLET, EXTENDED RELEASE | 348 mg | ORAL | NDA | 29 sections |
Aplenzin | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0187-5811 | TABLET, EXTENDED RELEASE | 348 mg | ORAL | NDA | 29 sections |
Aplenzin | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0187-5812 | TABLET, EXTENDED RELEASE | 522 mg | ORAL | NDA | 29 sections |
Aplenzin | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0187-5812 | TABLET, EXTENDED RELEASE | 522 mg | ORAL | NDA | 29 sections |
Bupropion Hydrochloride | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0440-7200 | TABLET, FILM COATED, EXTENDED RELEASE | 150 mg | ORAL | ANDA | 28 sections |
Bupropion hydrochloride (XL) | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0527-2415 | TABLET, EXTENDED RELEASE | 150 mg | ORAL | ANDA | 21 sections |