bosutinib Indications/Contra | FAERs-F | FAERs-M | Orange Bk | BioActivity |

Stem definitionDrug idCAS RN
tyrosine kinase inhibitors 4359 380843-75-4

Description:

MoleculeDescription

Molfile Inchi Smiles

Synonyms:

  • WAY-173606
  • bosutinib
  • bosulif
  • bosutinib monohydrate
  • bosutinib hydrate
  • SKI-606
  • SKI 606
a 4-anilino-3-quinolinecarbonitrile dual inhibitor of Src and Abl kinases
  • Molecular weight: 530.45
  • Formula: C26H29Cl2N5O3
  • CLOGP: 4.94
  • LIPINSKI: 1
  • HAC: 8
  • HDO: 1
  • TPSA: 82.88
  • ALOGS: -4.75
  • ROTB: 9

  • Status: OFP

  • Legend:
    OFP - off patent
    OFM - off market
    ONP - on patent

Drug dosage:

None

ADMET properties:

None

Approvals:

DateAgencyCompanyOrphan
Sept. 4, 2012 FDA WYETH PHARMS INC
Sept. 26, 2014 PMDA Pfizer Japan Inc

FDA Adverse Event Reporting System (Female)

MedDRA adverse event termLikelihood ratioLikelihood ratio thresholdPatients taking drug having adverse eventPatients taking drug not having adverse eventPatients not taking drug having adverse eventPatients not taking drug not having adverse event
Diarrhoea 635.03 26.66 481 4135 559121 46122325
Nausea 173.53 26.66 269 4347 687185 45994261
Neoplasm progression 114.98 26.66 55 4561 26628 46654818
Chronic myeloid leukaemia 91.15 26.66 25 4591 2433 46679013
Rash 77.23 26.66 131 4485 356381 46325065
Pleural effusion 76.03 26.66 64 4552 82888 46598558
Vomiting 70.09 26.66 144 4472 452650 46228796
Cytogenetic analysis abnormal 63.14 26.66 14 4602 562 46680884
Fatigue 39.95 26.66 141 4475 608556 46072890
Abdominal pain 38.74 26.66 76 4540 229955 46451491
Abdominal pain upper 34.74 26.66 56 4560 145249 46536197
Blast crisis in myelogenous leukaemia 27.62 26.66 7 4609 501 46680945

FDA Adverse Event Reporting System (Male)

MedDRA adverse event termLikelihood ratioLikelihood ratio thresholdPatients taking drug having adverse eventPatients taking drug not having adverse eventPatients not taking drug having adverse eventPatients not taking drug not having adverse event
Diarrhoea 429.84 25.20 352 3674 333751 29614701
Pleural effusion 175.26 25.20 114 3912 73952 29874500
Neoplasm progression 148.44 25.20 64 3962 17959 29930493
Chronic myeloid leukaemia 117.85 25.20 33 3993 2544 29945908
Cytogenetic analysis abnormal 109.51 25.20 22 4004 395 29948057
Nausea 80.74 25.20 143 3883 296814 29651638
Drug intolerance 74.67 25.20 56 3970 45235 29903217
Drug resistance 65.26 25.20 38 3988 20095 29928357
Abdominal discomfort 52.33 25.20 47 3979 48744 29899708
Fatigue 50.96 25.20 124 3902 320549 29627903
Rash 45.04 25.20 87 3939 191802 29756650
Second primary malignancy 43.96 25.20 20 4006 6336 29942116
Acquired gene mutation 40.28 25.20 12 4014 1149 29947303
Blast crisis in myelogenous leukaemia 34.56 25.20 9 4017 525 29947927
Fluid retention 32.69 25.20 27 3999 24971 29923481
Loss of therapeutic response 30.57 25.20 6 4020 95 29948357
Clonal evolution 29.29 25.20 6 4020 119 29948333
Abdominal pain 27.55 25.20 58 3968 135596 29812856
Peripheral arterial occlusive disease 25.79 25.20 13 4013 5155 29943297

Pharmacologic Action:

SourceCodeDescription
ATC L01EA04 ANTINEOPLASTIC AND IMMUNOMODULATING AGENTS
ANTINEOPLASTIC AGENTS
PROTEIN KINASE INHIBITORS
BCR-ABL tyrosine kinase inhibitors
FDA MoA N0000175076 Protein Kinase Inhibitors
FDA EPC N0000175605 Kinase Inhibitor
FDA MoA N0000185503 P-Glycoprotein Inhibitors
CHEBI has role CHEBI:35610 cytostatic
CHEBI has role CHEBI:38637 tyrosine kinase inhibitors

Drug Use (View source of the data)

DiseaseRelationSNOMED_IDDOID
Blastic phase chronic myeloid leukemia indication 413656006
Chronic Myelocytic Leukemia Accelerated Phase indication

Acid dissociation constants calculated using MoKa v3.0.0

Dissociation levelDissociation constantType (acidic/basic)
pKa1 8.74 Basic
pKa2 6.69 Basic
pKa3 4.74 Basic

Orange Book patent data (new drug applications)

None

Orange Book exclusivity data (new drug applications)

Formulation strengthTrade nameApplicantApplication numberApproval dateTypeDose formRouteExclusivity dateDescription
EQ 100MG BASE BOSULIF PF PRISM CV N203341 Sept. 4, 2012 RX TABLET ORAL Dec. 19, 2024 TREATMENT OF ADULT PATIENTS WITH NEWLY-DIAGNOSED CHRONIC PHASE (CP) PHILADELPHIA CHROMOSOME-POSITIVE CHRONIC MYELOGENOUS LEUKEMIA (PH+ CML)
EQ 400MG BASE BOSULIF PF PRISM CV N203341 Oct. 27, 2017 RX TABLET ORAL Dec. 19, 2024 TREATMENT OF ADULT PATIENTS WITH NEWLY-DIAGNOSED CHRONIC PHASE (CP) PHILADELPHIA CHROMOSOME-POSITIVE CHRONIC MYELOGENOUS LEUKEMIA (PH+ CML)
EQ 500MG BASE BOSULIF PF PRISM CV N203341 Sept. 4, 2012 RX TABLET ORAL Dec. 19, 2024 TREATMENT OF ADULT PATIENTS WITH NEWLY-DIAGNOSED CHRONIC PHASE (CP) PHILADELPHIA CHROMOSOME-POSITIVE CHRONIC MYELOGENOUS LEUKEMIA (PH+ CML)

Bioactivity Summary:

TargetClassPharosUniProtActionTypeActivity value
(-log[M])
Mechanism
action
Bioact sourceMoA source
Proto-oncogene tyrosine-protein kinase Src Kinase INHIBITOR Kd 9 CHEMBL CHEMBL
Tyrosine-protein kinase ABL1 Kinase INHIBITOR Kd 10.54 CHEMBL CHEMBL
Tyrosine-protein kinase HCK Kinase INHIBITOR Kd 8.47 CHEMBL CHEMBL
Tyrosine-protein kinase Lyn Kinase INHIBITOR Kd 8.38 CHEMBL CHEMBL
Serine/threonine-protein kinase 35 Kinase Kd 8.70 CHEMBL
Platelet-derived growth factor receptor alpha Kinase Kd 5.29 CHEMBL
Serine/threonine-protein kinase RIO3 Kinase Kd 5.80 CHEMBL
Hepatocyte growth factor receptor Kinase Kd 5.66 CHEMBL
Casein kinase I isoform epsilon Kinase Kd 6.96 CHEMBL
Myosin-IIIb Kinase Kd 5.64 CHEMBL
Dual specificity mitogen-activated protein kinase kinase 3 Kinase Kd 5.59 CHEMBL
Serine/threonine-protein kinase PAK 3 Kinase Kd 5.24 CHEMBL
Cyclin-dependent kinase 15 Kinase Kd 5.80 CHEMBL
Receptor-interacting serine/threonine-protein kinase 2 Kinase Kd 5.43 CHEMBL
Ephrin type-B receptor 4 Kinase Kd 8.04 CHEMBL
Tyrosine-protein kinase JAK2 Kinase Kd 5.96 CHEMBL
Ribosomal protein S6 kinase alpha-6 Kinase Kd 5.57 CHEMBL
Serine/threonine-protein kinase NIM1 Kinase Kd 5.82 CHEMBL
Cyclin-G-associated kinase Kinase Kd 8.89 CHEMBL
Microtubule-associated serine/threonine-protein kinase 1 Kinase Kd 6.46 CHEMBL
Dual specificity mitogen-activated protein kinase kinase 5 Kinase Kd 8.09 CHEMBL
Casein kinase I isoform delta Kinase Kd 6.62 CHEMBL
Tyrosine-protein kinase ITK/TSK Kinase Kd 5.77 CHEMBL
Mitogen-activated protein kinase kinase kinase MLT Kinase Kd 7.10 CHEMBL
Homeodomain-interacting protein kinase 3 Kinase Kd 5.49 CHEMBL
Homeodomain-interacting protein kinase 2 Kinase Kd 5.72 CHEMBL
Tyrosine-protein kinase SYK Kinase Kd 6.54 CHEMBL
Serine/threonine-protein kinase PLK1 Kinase Kd 5.74 CHEMBL
Wee1-like protein kinase Kinase Kd 6.29 CHEMBL
Tyrosine-protein kinase BTK Kinase Kd 8.32 CHEMBL
NUAK family SNF1-like kinase 1 Kinase Kd 5.23 CHEMBL
Mitogen-activated protein kinase kinase kinase 13 Kinase Kd 6.32 CHEMBL
Serine/threonine-protein kinase TBK1 Kinase Kd 6.60 CHEMBL
Ephrin type-A receptor 1 Kinase Kd 5.64 CHEMBL
Mitogen-activated protein kinase kinase kinase kinase 1 Kinase Kd 7.82 CHEMBL
Serine/threonine-protein kinase Nek11 Kinase Kd 6.19 CHEMBL
Tyrosine-protein kinase Fgr Kinase Kd 8.20 CHEMBL
Serine/threonine-protein kinase D3 Kinase Kd 5.34 CHEMBL
STE20/SPS1-related proline-alanine-rich protein kinase Kinase Kd 5.43 CHEMBL
Mitogen-activated protein kinase kinase kinase 7 Kinase Kd 7 CHEMBL
Dual specificity protein kinase CLK2 Kinase Kd 5.77 CHEMBL
Dual specificity protein kinase CLK3 Kinase Kd 6.52 CHEMBL
G protein-coupled receptor kinase 7 Kinase Kd 5.77 CHEMBL
Tyrosine-protein kinase FRK Kinase Kd 8.85 CHEMBL
Homeodomain-interacting protein kinase 1 Kinase Kd 6.28 CHEMBL
Dual specificity protein kinase CLK1 Kinase Kd 6.22 CHEMBL
Ephrin type-A receptor 8 Kinase Kd 8.05 CHEMBL
Ephrin type-A receptor 2 Kinase Kd 7.74 CHEMBL
Ephrin type-A receptor 3 Kinase Kd 8.24 CHEMBL
Serine/threonine-protein kinase tousled-like 2 Kinase Kd 5.68 CHEMBL
Serine/threonine-protein kinase 10 Kinase Kd 8.15 CHEMBL
Tyrosine-protein kinase Fer Kinase Kd 6.44 CHEMBL
Calcium/calmodulin-dependent protein kinase type II subunit gamma Kinase Kd 5.44 CHEMBL
AP2-associated protein kinase 1 Kinase Kd 5.64 CHEMBL
Protein kinase C epsilon type Kinase Kd 5.62 CHEMBL
Tyrosine-protein kinase JAK3 Kinase Kd 5.92 CHEMBL
Tyrosine-protein kinase Yes Kinase Kd 8.40 CHEMBL
Serine/threonine-protein kinase N2 Kinase Kd 5.49 CHEMBL
Tyrosine-protein kinase CSK Kinase Kd 7.49 CHEMBL
Serine/threonine-protein kinase TAO1 Kinase Kd 5.89 CHEMBL
Serine/threonine-protein kinase TNNI3K Kinase Kd 6.77 CHEMBL
Receptor tyrosine-protein kinase erbB-2 Kinase Kd 5.60 CHEMBL
Phosphorylase b kinase gamma catalytic chain, liver/testis isoform Kinase Kd 5.89 CHEMBL
High affinity nerve growth factor receptor Kinase Kd 5.51 CHEMBL
Platelet-derived growth factor receptor beta Kinase Kd 6.70 CHEMBL
Rho-associated protein kinase 1 Kinase Kd 6.06 CHEMBL
Citron Rho-interacting kinase Kinase Kd 5.62 CHEMBL
Ribosomal protein S6 kinase alpha-3 Kinase Kd 5.92 CHEMBL
Myosin-IIIa Kinase Kd 5.21 CHEMBL
Ankyrin repeat and protein kinase domain-containing protein 1 Kinase Kd 5.68 CHEMBL
Homeodomain-interacting protein kinase 4 Kinase Kd 6.89 CHEMBL
Serine/threonine-protein kinase 25 Kinase Kd 6.05 CHEMBL
Myosin light chain kinase, smooth muscle Kinase Kd 6.31 CHEMBL
Mitogen-activated protein kinase kinase kinase 4 Kinase Kd 6.96 CHEMBL
Mitogen-activated protein kinase kinase kinase kinase 5 Kinase Kd 9.30 CHEMBL
Misshapen-like kinase 1 Kinase Kd 8.49 CHEMBL
Casein kinase I isoform alpha-like Kinase Kd 5.59 CHEMBL
Leucine-rich repeat serine/threonine-protein kinase 2 Kinase Kd 6.30 CHEMBL
Serine/threonine-protein kinase 36 Kinase Kd 6.24 CHEMBL
Interleukin-1 receptor-associated kinase 4 Kinase Kd 6.44 CHEMBL
Mast/stem cell growth factor receptor Kit Kinase Kd 7.14 CHEMBL
BMP-2-inducible protein kinase Kinase Kd 6.46 CHEMBL
Receptor tyrosine-protein kinase erbB-4 Kinase Kd 7.59 CHEMBL
Mitogen-activated protein kinase kinase kinase 11 Kinase Kd 5.57 CHEMBL
Ephrin type-A receptor 6 Kinase Kd 5.96 CHEMBL
TRAF2 and NCK-interacting protein kinase Kinase Kd 7.51 CHEMBL
Megakaryocyte-associated tyrosine-protein kinase Kinase Kd 5.24 CHEMBL
Calcium/calmodulin-dependent protein kinase kinase 2 Kinase Kd 6.11 CHEMBL
Membrane-associated tyrosine- and threonine-specific cdc2-inhibitory kinase Kinase Kd 6.46 CHEMBL
STE20-like serine/threonine-protein kinase Kinase Kd 8.33 CHEMBL
Dual specificity protein kinase CLK4 Kinase Kd 5.49 CHEMBL
Macrophage-stimulating protein receptor Kinase Kd 5.20 CHEMBL
Non-receptor tyrosine-protein kinase TYK2 Kinase Kd 5.35 CHEMBL
Serine/threonine-protein kinase PAK 1 Kinase Kd 5.64 CHEMBL
Interleukin-1 receptor-associated kinase 1 Kinase Kd 6.22 CHEMBL
Serine/threonine-protein kinase 4 Kinase Kd 6.72 CHEMBL
Serine/threonine-protein kinase 3 Kinase Kd 6.43 CHEMBL
Calcium/calmodulin-dependent protein kinase type 1D Kinase Kd 6.26 CHEMBL
Serine/threonine-protein kinase TAO2 Kinase Kd 5.72 CHEMBL
Serine/threonine-protein kinase Nek2 Kinase Kd 5.80 CHEMBL
5'-AMP-activated protein kinase catalytic subunit alpha-1 Kinase Kd 5.41 CHEMBL
Ribosomal protein S6 kinase alpha-2 Kinase Kd 5.49 CHEMBL
Cytoplasmic tyrosine-protein kinase BMX Kinase Kd 6.70 CHEMBL
Ephrin type-A receptor 5 Kinase Kd 7.57 CHEMBL
Serine/threonine-protein kinase ULK2 Kinase Kd 6.35 CHEMBL
Ephrin type-A receptor 4 Kinase Kd 7.74 CHEMBL
NPM/ALK (Nucleophosmin/ALK tyrosine kinase receptor) Kinase IC50 6.82 CHEMBL
Phosphorylase b kinase gamma catalytic chain, skeletal muscle/heart isoform Kinase Kd 6.47 CHEMBL
Ephrin type-B receptor 1 Kinase Kd 7.48 CHEMBL
Activated CDC42 kinase 1 Kinase Kd 7.54 CHEMBL
Cyclin-dependent kinase 16 Kinase Kd 5.62 CHEMBL
Mitogen-activated protein kinase kinase kinase kinase 3 Kinase Kd 8.29 CHEMBL
Focal adhesion kinase 1 Kinase Kd 6.24 CHEMBL
NT-3 growth factor receptor Kinase Kd 5.47 CHEMBL
Tyrosine-protein kinase ZAP-70 Kinase Kd 5.80 CHEMBL
Calcium/calmodulin-dependent protein kinase type II subunit alpha Kinase Kd 5.35 CHEMBL
G protein-coupled receptor kinase 4 Kinase Kd 5.31 CHEMBL
Mitogen-activated protein kinase kinase kinase 2 Kinase Kd 7.52 CHEMBL
Serine/threonine-protein kinase ULK3 Kinase Kd 6.34 CHEMBL
Abelson tyrosine-protein kinase 2 Kinase Kd 8.82 CHEMBL
Eukaryotic translation initiation factor 2-alpha kinase 1 Kinase Kd 6.20 CHEMBL
Serine/threonine-protein kinase 26 Kinase Kd 7.43 CHEMBL
Serine/threonine-protein kinase PLK2 Kinase Kd 6.02 CHEMBL
Bone morphogenetic protein receptor type-2 Kinase Kd 6.24 CHEMBL
Protein-tyrosine kinase 2-beta Kinase Kd 6.41 CHEMBL
Tyrosine-protein kinase Blk Kinase Kd 8.48 CHEMBL
Angiopoietin-1 receptor Kinase Kd 5.41 CHEMBL
Inhibitor of nuclear factor kappa-B kinase subunit epsilon Kinase Kd 7.28 CHEMBL
Dual specificity mitogen-activated protein kinase kinase 7 Kinase Kd 5.28 CHEMBL
Peripheral plasma membrane protein CASK Kinase Kd 6.08 CHEMBL
Dual serine/threonine and tyrosine protein kinase Kinase Kd 6.42 CHEMBL
Receptor tyrosine-protein kinase erbB-3 Kinase Kd 9.11 CHEMBL
Ephrin type-B receptor 6 Kinase Kd 5.52 CHEMBL
Serine/threonine-protein kinase SIK2 Kinase Kd 7.54 CHEMBL
Serine/threonine-protein kinase TAO3 Kinase Kd 6.47 CHEMBL
Tyrosine-protein kinase Srms Kinase Kd 7 CHEMBL
Casein kinase I isoform alpha Kinase Kd 6.55 CHEMBL
Mitogen-activated protein kinase kinase kinase 1 Kinase Kd 5.36 CHEMBL
Cyclin-dependent kinase 7 Kinase Kd 5.92 CHEMBL
Serine/threonine-protein kinase 32A Kinase Kd 5.74 CHEMBL
Serine/threonine-protein kinase SIK3 Kinase Kd 7.19 CHEMBL
Rho-associated protein kinase 2 Kinase Kd 6.44 CHEMBL
Serine/threonine-protein kinase 24 Kinase Kd 6.42 CHEMBL
Tyrosine-protein kinase Fyn Kinase Kd 7.96 CHEMBL
Tyrosine-protein kinase ABL Kinase IC50 8.96 CHEMBL
Wee1-like protein kinase 2 Kinase Kd 7.03 CHEMBL
Macrophage colony-stimulating factor 1 receptor Kinase Kd 6.42 CHEMBL
Hormonally up-regulated neu tumor-associated kinase Kinase Kd 5.30 CHEMBL
Discoidin domain-containing receptor 2 Kinase Kd 6.85 CHEMBL
Protein kinase C delta type Kinase Kd 5.80 CHEMBL
Tyrosine-protein kinase receptor Tie-1 Kinase Kd 5.54 CHEMBL
Serine/threonine-protein kinase DCLK3 Kinase Kd 5.27 CHEMBL
Cyclin-dependent kinase 14 Kinase Kd 5.85 CHEMBL
Eukaryotic translation initiation factor 2-alpha kinase 4 Kinase Kd 6.57 CHEMBL
Proto-oncogene tyrosine-protein kinase receptor Ret Kinase Kd 5.42 CHEMBL
Myotonin-protein kinase Kinase Kd 7.04 CHEMBL
Epithelial discoidin domain-containing receptor 1 Kinase Kd 6.92 CHEMBL
Mitogen-activated protein kinase kinase kinase kinase 4 Kinase Kd 8.09 CHEMBL
Serine/threonine-protein kinase PAK 2 Kinase Kd 5.72 CHEMBL
Tyrosine-protein kinase receptor TYRO3 Kinase Kd 7.21 CHEMBL
Tyrosine-protein kinase Fes/Fps Kinase Kd 6.48 CHEMBL
Tyrosine-protein kinase Lck Kinase Kd 9.23 CHEMBL
Mitogen-activated protein kinase kinase kinase 9 Kinase Kd 5.57 CHEMBL
Leukocyte tyrosine kinase receptor Kinase Kd 5.52 CHEMBL
Mitogen-activated protein kinase kinase kinase 19 Kinase Kd 7.80 CHEMBL
Tyrosine-protein kinase receptor UFO Kinase Kd 7.28 CHEMBL
BDNF/NT-3 growth factors receptor Kinase Kd 5.92 CHEMBL
NUAK family SNF1-like kinase 2 Kinase Kd 6.66 CHEMBL
Ephrin type-B receptor 2 Kinase Kd 8.08 CHEMBL
Dual specificity mitogen-activated protein kinase kinase 2 Kinase Kd 8 CHEMBL
Dual specificity mitogen-activated protein kinase kinase 4 Kinase Kd 5.59 CHEMBL
Serine/threonine-protein kinase tousled-like 1 Kinase Kd 6.24 CHEMBL
SRSF protein kinase 3 Kinase Kd 5.41 CHEMBL
Tyrosine-protein kinase TXK Kinase Kd 7.14 CHEMBL
Serine/threonine-protein kinase VRK2 Kinase Kd 6.15 CHEMBL
Dual specificity mitogen-activated protein kinase kinase 6 Kinase Kd 5.89 CHEMBL
ALK tyrosine kinase receptor Kinase Kd 6.16 CHEMBL
Ephrin type-B receptor 3 Kinase Kd 6.68 CHEMBL
Mitogen-activated protein kinase kinase kinase 12 Kinase Kd 6.17 CHEMBL
Tyrosine-protein kinase Tec Kinase Kd 5.49 CHEMBL
Phosphatidylinositol 4-phosphate 5-kinase type-1 alpha Kinase Kd 5.48 CHEMBL
Mitogen-activated protein kinase kinase kinase 3 Kinase Kd 7.27 CHEMBL
Bcr/Abl fusion protein Kinase IC50 7.70 CHEMBL
Serine/threonine-protein kinase RIO1 Kinase Kd 5.66 CHEMBL
Ribosomal protein S6 kinase beta-1 Kinase Kd 6.18 CHEMBL
Serine/threonine-protein kinase ULK1 Kinase Kd 5.92 CHEMBL
Serine/threonine-protein kinase 33 Kinase Kd 7.43 CHEMBL
Serine/threonine-protein kinase Chk2 Kinase Kd 6.92 CHEMBL
Testis-specific serine/threonine-protein kinase 1 Kinase Kd 5.34 CHEMBL
Serine/threonine-protein kinase NLK Kinase Kd 5.66 CHEMBL
Serine/threonine-protein kinase Chk1 Kinase Kd 5.52 CHEMBL
Serine/threonine-protein kinase N1 Kinase Kd 5.54 CHEMBL
Serine/threonine-protein kinase SIK1 Kinase Kd 7.52 CHEMBL
Mitogen-activated protein kinase kinase kinase kinase 2 Kinase Kd 8.51 CHEMBL
Tyrosine-protein kinase Mer Kinase Kd 6.96 CHEMBL
Dual specificity mitogen-activated protein kinase kinase 1 Kinase Kd 7.72 CHEMBL
Mitogen-activated protein kinase 7 Kinase Kd 5.64 CHEMBL
Receptor-type tyrosine-protein kinase FLT3 Kinase Kd 6 CHEMBL
Epidermal growth factor receptor Kinase Kd 7.74 CHEMBL
Protein kinase C theta type Kinase Kd 6.04 CHEMBL
Tyrosine-protein kinase Blk Kinase IC50 8.14 CHEMBL
Serine/threonine-protein kinase PknB Kinase Kd 5.26 CHEMBL

External reference:

IDSource
5018V4AEZ0 UNII
4031718 VUID
N0000185728 NUI
D03252 KEGG_DRUG
918639-08-4 SECONDARY_CAS_RN
4031718 VANDF
C3496923 UMLSCUI
CHEBI:68533 CHEBI
DB8 PDB_CHEM_ID
CHEMBL288441 ChEMBL_ID
DB06616 DRUGBANK_ID
8715 INN_ID
C471992 MESH_SUPPLEMENTAL_RECORD_UI
5328940 PUBCHEM_CID
5710 IUPHAR_LIGAND_ID
1307619 RXNORM
192772 MMSL
28803 MMSL
d07901 MMSL
014636 NDDF
703128001 SNOMEDCT_US
703585009 SNOMEDCT_US
703586005 SNOMEDCT_US

Pharmaceutical products:

ProductCategoryIngredientsNDCFormQuantityRouteMarketingLabel
BOSULIF HUMAN PRESCRIPTION DRUG LABEL 1 0069-0135 TABLET, FILM COATED 100 mg ORAL NDA 33 sections
BOSULIF HUMAN PRESCRIPTION DRUG LABEL 1 0069-0136 TABLET, FILM COATED 500 mg ORAL NDA 33 sections
BOSULIF HUMAN PRESCRIPTION DRUG LABEL 1 0069-0193 TABLET, FILM COATED 400 mg ORAL NDA 33 sections
BOSULIF HUMAN PRESCRIPTION DRUG LABEL 1 63539-117 TABLET, FILM COATED 100 mg ORAL NDA 29 sections