All FDA-approved EMA-approved PMDA-approved
Target Card Uniprot Example: P23975

calcium gluconate 🐶 Veterinary Use | Indications/Contra | FAERs-F | FAERs-M | Orange Bk | BioActivity |

Stem definition	Drug id	CAS RN
	4348	299-28-5

Description:

Molecule	Description
Synonyms: calcium gluconate calciofon Calcium D-gluconate calcium gluconate monohydrate	The calcium salt of gluconic acid. The compound has a variety of uses, including its use as a calcium replenisher in hypocalcemic states. Molecular weight: 430.37 Formula: C12H22CaO14 CLOGP: LIPINSKI: None HAC: None HDO: None TPSA: 141.28 ALOGS: ROTB: None

Drug dosage:

Dose	Unit	Route
3	g	O

ADMET properties:

None

Approvals:

Date	Agency	Company	Orphan
None	FDA

FDA Adverse Event Reporting System (Female)

MedDRA adverse event term	Likelihood ratio	Likelihood ratio threshold	Patients taking drug having adverse event	Patients taking drug not having adverse event	Patients not taking drug having adverse event	Patients not taking drug not having adverse event
Liver injury	739.01	15.37	459	38094	60061	63390408
Psoriatic arthropathy	625.87	15.37	486	38067	91034	63359435
Glossodynia	342.17	15.37	479	38074	178397	63272072
Pemphigus	326.42	15.37	475	38078	183251	63267218
Rheumatoid arthritis	284.32	15.37	533	38020	253286	63197183
Systemic lupus erythematosus	281.87	15.37	476	38077	208442	63242027
Arthropathy	272.88	15.37	501	38052	234291	63216178
Product use issue	210.24	15.37	433	38120	220087	63230382
Contraindicated product administered	201.19	15.37	422	38131	217226	63233243
Alopecia	197.43	15.37	548	38005	336988	63113481
Abdominal discomfort	172.03	15.37	505	38048	320380	63130089
Prescribed overdose	155.98	15.37	144	38409	34009	63416460
Hand deformity	155.22	15.37	316	38237	159141	63291328
Wound	143.13	15.37	310	38243	162953	63287516
Maternal exposure during pregnancy	133.07	15.37	362	38191	219700	63230769
Rheumatic fever	131.29	15.37	146	38407	42965	63407504
Fibromyalgia	129.70	15.37	199	38354	80221	63370248
Swollen joint count increased	120.07	15.37	128	38425	35926	63414543
Discomfort	111.97	15.37	286	38267	167088	63283381
Hip arthroplasty	97.43	15.37	132	38421	47514	63402955
Knee arthroplasty	90.00	15.37	136	38417	54070	63396399
Rheumatoid factor positive	88.90	15.37	173	38380	84233	63366236
Intentional product use issue	87.01	15.37	220	38333	127672	63322797
Pericarditis	86.05	15.37	223	38330	131356	63319113
Product dose omission issue	85.23	15.37	19	38534	234294	63216175
Blood cholesterol increased	81.67	15.37	178	38375	93854	63356615
Fall	81.65	15.37	71	38482	392263	63058206
Anti-cyclic citrullinated peptide antibody positive	81.23	15.37	202	38351	116010	63334459
Dislocation of vertebra	79.54	15.37	55	38498	8580	63441889
Type 2 diabetes mellitus	77.35	15.37	139	38414	63729	63386740
Duodenal ulcer perforation	76.78	15.37	166	38387	87043	63363426
Injury	75.75	15.37	149	38404	73098	63377371
Lupus vulgaris	74.35	15.37	46	38507	5948	63444521
Adjustment disorder with depressed mood	71.31	15.37	55	38498	10149	63440320
Live birth	69.89	15.37	82	38471	25548	63424921
Prescribed underdose	68.03	15.37	87	38466	29602	63420867
Oedema	64.36	15.37	166	38387	97456	63353013
Helicobacter infection	63.48	15.37	160	38393	92625	63357844
Synovitis	62.75	15.37	252	38301	186666	63263803
Anti-cyclic citrullinated peptide antibody	57.49	15.37	41	38512	6717	63443752
Mobility decreased	56.57	15.37	182	38371	120977	63329492
Swelling	55.21	15.37	320	38233	275058	63175411
Death	55.12	15.37	89	38464	374292	63076177
Product complaint	54.60	15.37	52	38501	12757	63437712
Treatment failure	51.33	15.37	248	38305	198795	63251674
Skin reaction	48.15	15.37	52	38501	14797	63435672
Dyspnoea	46.06	15.37	226	38327	661087	62789382
Drug interaction	45.76	15.37	43	38510	229088	63221381
Vascular access complication	44.62	15.37	23	38530	2095	63448374
Musculoskeletal deformity	43.92	15.37	22	38531	1887	63448582
Drug intolerance	43.80	15.37	329	38224	308332	63142137
Red cell distribution width decreased	42.28	15.37	22	38531	2043	63448426
Breast cancer stage III	42.07	15.37	41	38512	10345	63440124
Blood immunoglobulin A decreased	41.99	15.37	19	38534	1298	63449171
Blood immunoglobulin M increased	41.30	15.37	18	38535	1125	63449344
Toxicity to various agents	41.04	15.37	54	38499	247196	63203273
Deep vein thrombosis postoperative	40.76	15.37	42	38511	11327	63439142
Sciatica	40.64	15.37	74	38479	34250	63416219
Amnesia	40.26	15.37	98	38455	55487	63394982
Grip strength decreased	38.52	15.37	57	38496	22230	63428239
Facet joint syndrome	38.47	15.37	42	38511	12096	63438373
Peripheral venous disease	38.07	15.37	47	38506	15430	63435039
Blister	38.06	15.37	168	38385	129646	63320823
Infusion site reaction	35.77	15.37	24	38529	3563	63446906
Wheezing	35.39	15.37	133	38420	95462	63355007
Hepatic enzyme increased	35.36	15.37	227	38326	202101	63248368
Posthaemorrhagic hydrocephalus	35.16	15.37	7	38546	21	63450448
Lip dry	34.91	15.37	45	38508	15425	63435044
Wound infection	34.50	15.37	53	38500	21357	63429112
Mean platelet volume decreased	34.42	15.37	21	38532	2648	63447821
Injection site pain	34.29	15.37	18	38535	129782	63320687
Infusion related reaction	33.29	15.37	259	38294	245262	63205207
Autoimmune disorder	32.71	15.37	46	38507	17131	63433338
Influenza	31.93	15.37	13	38540	108709	63341760
Cough	31.67	15.37	83	38470	292660	63157809
Physical disability	31.35	15.37	20	38533	2728	63447741
Blood immunoglobulin G increased	31.05	15.37	19	38534	2408	63448061
Walking aid user	30.40	15.37	35	38518	10682	63439787
Pain	29.50	15.37	621	37932	740007	62710462
Back pain	29.25	15.37	74	38479	264071	63186398
Colitis microscopic	29.05	15.37	32	38521	9307	63441162
Mean cell volume decreased	29.02	15.37	22	38531	3956	63446513
Osteoarthritis	28.40	15.37	124	38429	95219	63355250
Mean cell haemoglobin decreased	27.93	15.37	24	38529	5155	63445314
Musculoskeletal stiffness	27.40	15.37	199	38354	184419	63266050
Adverse drug reaction	27.12	15.37	108	38445	79606	63370863
Maternal exposure before pregnancy	27.09	15.37	28	38525	7575	63442894
COVID-19	26.61	15.37	18	38535	113085	63337384
Urinary tract infection	26.42	15.37	78	38475	264606	63185863
Hypocalcaemia	26.34	15.37	59	38494	31654	63418815
Suspected transmission of an infectious agent via product	26.23	15.37	9	38544	293	63450176
Hypertension	25.74	15.37	271	38282	279032	63171437
Disease progression	25.73	15.37	22	38531	122736	63327733
Exposure during pregnancy	25.63	15.37	172	38381	155375	63295094
X-ray abnormal	25.59	15.37	28	38525	8082	63442387
Eye injury	25.39	15.37	18	38535	2921	63447548
Red blood cell sedimentation rate	25.17	15.37	22	38531	4832	63445637
Wrong technique in product usage process	24.88	15.37	4	38549	62336	63388133
Hiccups	24.86	15.37	16	38537	2215	63448254
Somnolence	24.84	15.37	44	38509	178641	63271828
Seronegative arthritis	24.78	15.37	20	38533	3939	63446530
Rheumatic disorder	24.67	15.37	18	38535	3054	63447415
Joint destruction	24.06	15.37	24	38529	6228	63444241
Balance disorder	23.36	15.37	11	38542	84411	63366058
Macular degeneration	23.29	15.37	48	38505	24328	63426141
Recalled product	23.28	15.37	13	38540	1390	63449079
Nail infection	23.07	15.37	16	38537	2507	63447962
Product compounding quality issue	22.47	15.37	5	38548	29	63450440
Disability	22.28	15.37	40	38513	18307	63432162
General physical health deterioration	22.25	15.37	203	38350	201199	63249270
Hospitalisation	22.17	15.37	12	38541	85069	63365400
Thrombosis	22.06	15.37	6	38547	64749	63385720
Tremor	21.80	15.37	29	38524	132210	63318259
Therapeutic product effect decreased	21.48	15.37	195	38358	192992	63257477
Cystic fibrosis	21.37	15.37	17	38536	3279	63447190
Hypoaesthesia	21.35	15.37	175	38378	168218	63282251
Productive cough	21.26	15.37	6	38547	63202	63387267
Adverse event	20.98	15.37	89	38464	67470	63382999
Inappropriate schedule of product administration	20.17	15.37	20	38533	103945	63346524
Syncope	20.12	15.37	25	38528	117360	63333109
Stress	19.77	15.37	8	38545	67159	63383310
Culture positive	19.53	15.37	8	38545	428	63450041
Hypercholesterolaemia	19.20	15.37	41	38512	21293	63429176
Neonatal infection	19.10	15.37	6	38547	147	63450322
Nasal congestion	19.04	15.37	8	38545	65652	63384817
Rhinorrhoea	18.99	15.37	8	38545	65569	63384900
Monocyte count increased	18.82	15.37	23	38530	7470	63442999
Hyperplastic cholecystopathy	18.73	15.37	6	38547	157	63450312
Oropharyngeal pain	18.53	15.37	18	38535	94469	63356000
Hypercalcaemia	18.48	15.37	48	38505	28274	63422195
Endometritis	18.46	15.37	10	38543	1008	63449461
Oxygen saturation decreased	18.41	15.37	16	38537	88569	63361900
Distributive shock	18.14	15.37	11	38542	1372	63449097
Malignant neoplasm progression	18.10	15.37	14	38539	82107	63368362
Influenza like illness	18.04	15.37	9	38544	66815	63383654
Hyperdynamic left ventricle	17.95	15.37	6	38547	180	63450289
Epistaxis	17.89	15.37	11	38542	72714	63377755
Blood calcium increased	17.74	15.37	25	38528	9325	63441144
Poor peripheral circulation	17.48	15.37	16	38537	3733	63446736
C-reactive protein	17.43	15.37	18	38535	4864	63445605
Myocardial infarction	17.40	15.37	21	38532	99872	63350597
Drug tolerance decreased	17.39	15.37	35	38518	17438	63433031
Electrocardiogram U wave present	17.07	15.37	5	38548	96	63450373
Injection site swelling	16.99	15.37	4	38549	47568	63402901
Feeling abnormal	16.86	15.37	41	38512	148351	63302118
Delirium	16.81	15.37	68	38485	50473	63399996
Therapeutic response decreased	16.80	15.37	78	38475	61447	63389022
Hepatic enzyme abnormal	16.68	15.37	20	38533	6372	63444097
Glaucoma	16.63	15.37	36	38517	18869	63431600
Cerebrovascular accident	16.50	15.37	25	38528	107999	63342470
Insomnia	16.43	15.37	71	38482	215181	63235288
Vision blurred	16.36	15.37	19	38534	91905	63358564
Hypersensitivity	16.35	15.37	259	38294	292426	63158043
Blood pressure fluctuation	16.33	15.37	4	38549	46313	63404156
Pruritus	16.17	15.37	141	38412	361312	63089157
Multiple drug therapy	15.92	15.37	15	38538	3631	63446838
Lower limb fracture	15.75	15.37	41	38512	24180	63426289
Neutropenia	15.75	15.37	54	38499	174951	63275518
Interstitial lung disease	15.74	15.37	9	38544	61899	63388570
Myalgia	15.48	15.37	42	38511	146487	63303982
Underdose	15.38	15.37	44	38509	27412	63423057

FDA Adverse Event Reporting System (Male)

MedDRA adverse event term	Likelihood ratio	Likelihood ratio threshold	Patients taking drug having adverse event	Patients taking drug not having adverse event	Patients not taking drug having adverse event	Patients not taking drug not having adverse event
Toxic epidermal necrolysis	150.96	15.83	85	9093	21561	34926192
Lymphocyte count decreased	62.57	15.83	50	9128	22572	34925181
Multiple organ dysfunction syndrome	52.19	15.83	81	9097	76485	34871268
Cytokine release syndrome	45.76	15.83	42	9136	22835	34924918
Hypocalcaemia	45.52	15.83	43	9135	24246	34923507
Blood uric acid increased	41.91	15.83	28	9150	9596	34938157
Blood phosphorus increased	39.86	15.83	25	9153	7696	34940057
Hypokalaemia	37.45	15.83	60	9118	58154	34889599
Sepsis	32.69	15.83	107	9071	166454	34781299
Hyperphosphataemia	32.46	15.83	18	9160	4419	34943334
Myasthenia gravis	32.18	15.83	21	9157	6919	34940834
Red blood cells urine positive	30.51	15.83	13	9165	1796	34945957
Appendicolith	30.36	15.83	22	9156	8579	34939174
Incision site pain	30.31	15.83	13	9165	1825	34945928
Immune effector cell-associated neurotoxicity syndrome	29.76	15.83	16	9162	3697	34944056
Cardiogenic shock	28.42	15.83	35	9143	26583	34921170
Blood urea increased	27.81	15.83	37	9141	30327	34917426
Ventricular fibrillation	27.49	15.83	32	9146	22922	34924831
Protein urine present	27.17	15.83	17	9161	5211	34942542
Benign abdominal neoplasm	26.86	15.83	6	9172	90	34947663
Procedural pain	25.91	15.83	16	9162	4790	34942963
Hypophosphataemia	25.53	15.83	22	9156	11004	34936749
Posthaemorrhagic hydrocephalus	25.24	15.83	6	9172	120	34947633
Hypotension	24.52	15.83	119	9059	221530	34726223
Herpes zoster reactivation	24.42	15.83	7	9171	296	34947457
Neutrophil count increased	24.12	15.83	26	9152	17120	34930633
Wrong patient	24.00	15.83	6	9172	149	34947604
Chest expansion decreased	24.00	15.83	6	9172	149	34947604
Appendicitis	23.60	15.83	24	9154	14783	34932970
Hyponatraemia	22.78	15.83	60	9118	82631	34865122
Blood creatinine increased	22.30	15.83	65	9113	94911	34852842
Abdominal distension	22.12	15.83	48	9130	58444	34889309
Blood cholesterol increased	21.91	15.83	27	9151	20516	34927237
Hyperkalaemia	21.88	15.83	53	9125	69336	34878417
Product preparation error	21.46	15.83	11	9167	2306	34945447
Scrotal pain	20.37	15.83	8	9170	898	34946855
Lactobacillus test positive	20.20	15.83	4	9174	32	34947721
Cardiac arrest	19.93	15.83	63	9115	96096	34851657
Analgesic therapy	19.62	15.83	8	9170	990	34946763
Hypoxia	19.46	15.83	44	9134	55051	34892702
Sleep disorder therapy	19.42	15.83	8	9170	1015	34946738
Hypercalcaemia	19.25	15.83	22	9156	15446	34932307
Axial spondyloarthritis	19.13	15.83	6	9172	346	34947407
Stress	19.11	15.83	31	9147	30316	34917437
Delayed graft function	19.01	15.83	10	9168	2211	34945542
Drug therapy	18.58	15.83	8	9170	1133	34946620
Blood albumin decreased	18.08	15.83	20	9158	13552	34934201
Pantoea agglomerans infection	18.03	15.83	4	9174	58	34947695
Respiratory failure	17.99	15.83	66	9112	108506	34839247
Hyperdynamic left ventricle	17.99	15.83	5	9173	189	34947564
Hypothalamo-pituitary disorder	17.51	15.83	7	9171	823	34946930
Product dose omission issue	17.28	15.83	5	9173	119706	34828047
Hepatitis	17.25	15.83	26	9152	23878	34923875
Fungal sepsis	17.24	15.83	7	9171	857	34946896
Aspartate aminotransferase increased	16.49	15.83	47	9131	67736	34880017

FDA Adverse Event Reporting System (Geriatric)

MedDRA adverse event term	Likelihood ratio	Likelihood ratio threshold	Patients taking drug having adverse event	Patients taking drug not having adverse event	Patients not taking drug having adverse event	Patients not taking drug not having adverse event
Liver injury	207.21	13.51	186	36238	56428	79651536
Psoriatic arthropathy	186.25	13.51	203	36221	77796	79630168
Rheumatic fever	155.19	13.51	118	36306	28407	79679557
Swollen joint count increased	136.23	13.51	100	36324	22827	79685137
Pemphigus	131.73	13.51	193	36231	99389	79608575
Glossodynia	129.13	13.51	195	36229	103142	79604822
Blood cholesterol increased	123.60	13.51	171	36253	83549	79624415
Hand deformity	121.28	13.51	190	36234	103729	79604235
Fibromyalgia	120.84	13.51	148	36276	64192	79643772
Prescribed overdose	114.60	13.51	112	36312	37771	79670193
Hip arthroplasty	108.70	13.51	106	36318	35650	79672314
Toxic epidermal necrolysis	101.13	13.51	113	36311	44468	79663496
Knee arthroplasty	100.47	13.51	111	36313	43137	79664827
Pericarditis	98.04	13.51	173	36251	104063	79603901
Systemic lupus erythematosus	96.28	13.51	187	36237	120962	79587002
Wound	95.61	13.51	182	36242	115997	79591967
Anti-cyclic citrullinated peptide antibody positive	95.58	13.51	151	36273	82992	79624972
Dislocation of vertebra	93.18	13.51	53	36371	7827	79700137
Completed suicide	88.84	13.51	6	36418	245761	79462203
Adjustment disorder with depressed mood	86.18	13.51	53	36371	9033	79698931
Duodenal ulcer perforation	82.75	13.51	125	36299	66086	79641878
Rheumatoid factor positive	82.04	13.51	118	36306	59721	79648243
Live birth	81.52	13.51	68	36356	18676	79689288
Discomfort	81.10	13.51	178	36246	125439	79582525
Arthropathy	80.26	13.51	219	36205	176892	79531072
Rheumatoid arthritis	80.18	13.51	243	36181	208227	79499737
Maternal exposure during pregnancy	75.48	13.51	182	36242	136356	79571608
Product complaint	74.31	13.51	56	36368	13293	79694671
Type 2 diabetes mellitus	73.03	13.51	109	36315	57013	79650951
Fall	69.73	13.51	72	36352	487557	79220407
Alopecia	68.66	13.51	247	36177	231108	79476856
Helicobacter infection	68.52	13.51	118	36306	69586	79638378
Contraindicated product administered	67.61	13.51	191	36233	157347	79550617
Synovitis	66.90	13.51	185	36239	150549	79557415
Mobility decreased	66.61	13.51	162	36262	122013	79585951
Injury	65.71	13.51	123	36301	77373	79630591
Prescribed underdose	58.83	13.51	70	36354	29444	79678520
Product dose omission issue	58.54	13.51	20	36404	247517	79460447
Lupus vulgaris	57.89	13.51	29	36395	3317	79704647
Treatment failure	56.63	13.51	189	36235	170297	79537667
Musculoskeletal deformity	54.23	13.51	22	36402	1534	79706430
Sciatica	53.78	13.51	71	36353	33151	79674813
Drug abuse	53.28	13.51	6	36418	162685	79545279
Death	53.27	13.51	112	36312	566402	79141562
Toxicity to various agents	52.94	13.51	69	36355	421471	79286493
Hypocalcaemia	52.35	13.51	87	36337	49837	79658127
Breast cancer stage III	52.00	13.51	40	36384	9786	79698178
Vascular access complication	50.20	13.51	23	36401	2159	79705805
Drug interaction	50.07	13.51	70	36354	415113	79292851
Facet joint syndrome	49.14	13.51	41	36383	11261	79696703
Red cell distribution width decreased	48.52	13.51	22	36402	2016	79705948
Blister	48.47	13.51	142	36282	119334	79588630
Grip strength decreased	47.14	13.51	54	36370	21815	79686149
Blood immunoglobulin A decreased	45.40	13.51	19	36405	1434	79706530
Anti-cyclic citrullinated peptide antibody	45.22	13.51	30	36394	5822	79702142
Deep vein thrombosis postoperative	44.68	13.51	38	36386	10714	79697250
Oedema	44.62	13.51	138	36286	119442	79588522
Peripheral venous disease	44.34	13.51	45	36379	15864	79692100
Hepatic enzyme increased	44.33	13.51	183	36241	182427	79525537
Blood immunoglobulin M increased	43.15	13.51	18	36406	1348	79706616
Intentional product use issue	43.06	13.51	160	36264	151952	79556012
Swelling	42.66	13.51	204	36220	216507	79491457
Hypoaesthesia	42.18	13.51	178	36246	179174	79528790
Mean platelet volume decreased	41.95	13.51	22	36402	2768	79705196
Lip dry	41.86	13.51	43	36381	15375	79692589
Wound infection	41.52	13.51	53	36371	23938	79684026
Drug intolerance	40.52	13.51	232	36192	263887	79444077
Autoimmune disorder	37.47	13.51	42	36382	16570	79691394
Infusion site reaction	37.33	13.51	22	36402	3471	79704493
Abdominal discomfort	35.72	13.51	216	36208	250511	79457453
Hypercalcaemia	35.09	13.51	63	36361	38367	79669597
Therapeutic product effect decreased	34.99	13.51	158	36266	163705	79544259
Product use issue	34.63	13.51	188	36236	209634	79498330
Walking aid user	34.47	13.51	32	36392	10116	79697848
Hyperdynamic left ventricle	34.18	13.51	11	36413	392	79707572
Physical disability	33.23	13.51	20	36404	3278	79704686
Blood immunoglobulin G increased	32.40	13.51	19	36405	2970	79704994
Osteoarthritis	31.86	13.51	100	36324	87209	79620755
X-ray abnormal	31.50	13.51	24	36400	5789	79702175
Joint destruction	31.09	13.51	24	36400	5901	79702063
Infusion related reaction	30.07	13.51	194	36230	230043	79477921
Multiple organ dysfunction syndrome	29.56	13.51	121	36303	120125	79587839
Rheumatic disorder	28.88	13.51	18	36406	3140	79704824
Suspected transmission of an infectious agent via product	28.86	13.51	13	36411	1173	79706791
Disability	28.34	13.51	37	36387	17083	79690881
Blood calcium increased	28.22	13.51	29	36395	10371	79697593
Incision site pain	28.10	13.51	17	36407	2813	79705151
Mean cell volume decreased	28.08	13.51	21	36403	4926	79703038
Red blood cell sedimentation rate	28.03	13.51	22	36402	5543	79702421
Nail infection	28.00	13.51	16	36408	2383	79705581
Mean cell haemoglobin decreased	27.93	13.51	23	36401	6201	79701763
Dyspnoea	27.85	13.51	254	36170	856771	78851193
COVID-19	27.74	13.51	19	36405	157655	79550309
Amnesia	27.55	13.51	77	36347	62980	79644984
Joint range of motion decreased	27.17	13.51	52	36372	33230	79674734
Seronegative arthritis	26.82	13.51	20	36404	4672	79703292
Adverse event	26.78	13.51	74	36350	60140	79647824
Poor peripheral circulation	26.35	13.51	18	36406	3665	79704299
Culture positive	26.31	13.51	12	36412	1114	79706850
Hypersensitivity	26.13	13.51	207	36217	262032	79445932
Wheezing	26.04	13.51	114	36310	116550	79591414
Adverse drug reaction	25.11	13.51	77	36347	66315	79641649
Recalled product	24.95	13.51	11	36413	943	79707021
Vaginal discharge	24.32	13.51	23	36401	7440	79700524
Colitis microscopic	23.90	13.51	27	36397	10741	79697223
Lower limb fracture	23.72	13.51	40	36384	23175	79684789
Influenza	23.63	13.51	15	36409	129591	79578373
Hyperphosphataemia	23.40	13.51	21	36403	6355	79701609
Endometritis	23.36	13.51	10	36414	798	79707166
Paraesthesia oral	23.26	13.51	37	36387	20434	79687530
Pantoea agglomerans infection	23.20	13.51	6	36418	96	79707868
Hypertension	23.14	13.51	242	36182	330750	79377214
Blood phosphorus increased	23.06	13.51	26	36398	10321	79697643
Blood uric acid increased	22.31	13.51	29	36395	13331	79694633
Product compounding quality issue	22.28	13.51	5	36419	42	79707922
Myocardial infarction	22.20	13.51	31	36393	184098	79523866
Night sweats	22.16	13.51	63	36361	52032	79655932
General physical health deterioration	22.04	13.51	207	36217	275031	79432933
Muscle injury	21.91	13.51	60	36364	48501	79659463
C-reactive protein	21.52	13.51	18	36406	4961	79703003
White blood cell count increased	21.51	13.51	79	36345	74554	79633410
Procedural pain	21.27	13.51	38	36386	23046	79684918
Hypophosphataemia	21.27	13.51	35	36389	19878	79688086
Small for dates baby	21.06	13.51	8	36416	468	79707496
Lymphocyte count decreased	20.91	13.51	58	36366	47231	79660733
Monocyte count increased	20.77	13.51	25	36399	10636	79697328
Musculoskeletal stiffness	20.75	13.51	144	36280	174864	79533100
Balance disorder	20.10	13.51	10	36414	98847	79609117
Neutropenia	20.02	13.51	66	36358	287644	79420320
Appendicolith	19.94	13.51	22	36402	8529	79699435
Inappropriate schedule of product administration	19.89	13.51	19	36405	133609	79574355
Injection site pain	19.87	13.51	18	36406	129820	79578144
Myasthenia gravis	19.63	13.51	24	36400	10375	79697589
Skin reaction	19.59	13.51	30	36394	16038	79691926
Red blood cells urine positive	19.52	13.51	17	36407	4946	79703018
Deformity	19.50	13.51	23	36401	9582	79698382
Chest expansion decreased	19.35	13.51	6	36418	189	79707775
Multiple fractures	19.32	13.51	21	36403	8005	79699959
Cardiac failure congestive	19.22	13.51	22	36402	142380	79565584
Distributive shock	18.91	13.51	13	36411	2674	79705290
Hypokalaemia	18.56	13.51	121	36303	143919	79564045
Hyperplastic cholecystopathy	18.56	13.51	6	36418	217	79707747
Cardiogenic shock	18.13	13.51	51	36373	41863	79666101
Hepatic enzyme abnormal	18.05	13.51	20	36404	7790	79700174
Lactobacillus test positive	17.88	13.51	4	36420	33	79707931
Cytokine release syndrome	17.78	13.51	46	36378	35952	79672012
Memory impairment	17.66	13.51	99	36325	111635	79596329
Disease progression	17.65	13.51	36	36388	184326	79523638
Hypercholesterolaemia	17.53	13.51	35	36389	23060	79684904
Wrong technique in product usage process	17.39	13.51	6	36418	73869	79634095
C-reactive protein abnormal	17.27	13.51	55	36369	48312	79659652
Irritable bowel syndrome	17.20	13.51	65	36359	62176	79645788
Benign abdominal neoplasm	17.09	13.51	6	36418	280	79707684
Electrocardiogram U wave present	17.04	13.51	5	36419	130	79707834
C-reactive protein increased	17.00	13.51	109	36315	128918	79579046
Protein urine present	16.96	13.51	22	36402	10090	79697874
Cataract operation	16.94	13.51	16	36408	5169	79702795
Drug tolerance decreased	16.91	13.51	25	36399	12953	79695011
Interstitial lung disease	16.77	13.51	16	36408	112584	79595380
Malignant neoplasm progression	16.29	13.51	23	36401	135967	79571997
Glaucoma	16.28	13.51	31	36393	19730	79688234
Folliculitis	16.28	13.51	59	36365	55321	79652643
Multiple drug therapy	16.10	13.51	14	36410	4064	79703900
Retinitis	15.79	13.51	16	36408	5627	79702337
Analgesic therapy	15.29	13.51	8	36416	1001	79706963
Joint swelling	15.25	13.51	200	36224	288446	79419518
Blood urea increased	15.22	13.51	53	36371	48737	79659227
Sleep disorder therapy	15.18	13.51	8	36416	1016	79706948
Neutrophil count increased	14.97	13.51	38	36386	29358	79678606
Bursitis	14.90	13.51	43	36381	35801	79672163
Syncope	14.78	13.51	38	36386	179411	79528553
Colour blindness	14.71	13.51	6	36418	424	79707540
Dry mouth	14.59	13.51	79	36345	87940	79620024
Cough	14.49	13.51	103	36321	366686	79341278
Hepatotoxicity	14.29	13.51	3	36421	51349	79656615
Hiccups	14.06	13.51	20	36404	10011	79697953
Drug therapy	13.99	13.51	8	36416	1193	79706771
CSF pressure increased	13.84	13.51	5	36419	254	79707710
Delayed graft function	13.77	13.51	12	36412	3495	79704469
Nasal congestion	13.76	13.51	9	36415	76543	79631421
Suicidal ideation	13.69	13.51	9	36415	76331	79631633
Stomatitis	13.60	13.51	114	36310	146643	79561321
Blepharospasm	13.55	13.51	15	36409	5836	79702128

FDA Adverse Event Reporting System (Pediatric)

None

Pharmacologic Action:

Source	Code	Description
ATC	A12AA03	ALIMENTARY TRACT AND METABOLISM MINERAL SUPPLEMENTS CALCIUM Calcium
ATC	D11AX03	DERMATOLOGICALS OTHER DERMATOLOGICAL PREPARATIONS OTHER DERMATOLOGICAL PREPARATIONS Other dermatologicals
CHEBI has role	CHEBI:50733	Dietary Supplement

Drug Use | Suggest Off label Use Form| |View source of the data|

Disease	Relation	SNOMED_ID	DOID
Hypocalcemia	indication	5291005
Osteoporosis	indication	64859006	DOID:11476
Hypocalcemic tetany	indication	190869004
Necrotizing enterocolitis in fetus OR newborn	contraindication	2707005
Alcoholism	contraindication	7200002
Poisoning by digitalis glycoside	contraindication	12876009
Peptic ulcer	contraindication	13200003	DOID:750
Constipation	contraindication	14760008	DOID:2089
Hyperphosphatemia	contraindication	20165001	DOID:0050459
Hypervitaminosis D	contraindication	27712000	DOID:9971
Sarcoidosis	contraindication	31541009	DOID:11335
Dehydration	contraindication	34095006
Hypertensive disorder	contraindication	38341003	DOID:10763
Gastrointestinal ulcer	contraindication	40845000
Conduction disorder of the heart	contraindication	44808001
End stage renal disease	contraindication	46177005	DOID:784
Humoral hypercalcemia of malignancy	contraindication	47709007
Vitamin K deficiency	contraindication	52675005	DOID:11249
Nasal polyp	contraindication	52756005
Heart disease	contraindication	56265001	DOID:114
Acute nephropathy	contraindication	58574008
Hepatic failure	contraindication	59927004
Hypercalcemia	contraindication	66931009	DOID:12678
Hyperparathyroidism	contraindication	66999008	DOID:13543
Poisoning by acetaminophen	contraindication	70273001
Agoraphobia	contraindication	70691001	DOID:593
Ventricular fibrillation	contraindication	71908006
Hypercalciuria	contraindication	71938000
Factor II deficiency	contraindication	73975000
Reye's syndrome	contraindication	74351001	DOID:14525
Gastrointestinal hemorrhage	contraindication	74474003
Thrombotic thrombocytopenic purpura	contraindication	78129009	DOID:10772
Gout	contraindication	90560007	DOID:13189
Kidney disease	contraindication	90708001	DOID:557
Hemophilia	contraindication	90935002
Kidney stone	contraindication	95570007
Anemia due to enzyme deficiency	contraindication	111577008
von Willebrand disorder	contraindication	128105004	DOID:12531
Seizure disorder	contraindication	128613002
Obsessive-compulsive disorder	contraindication	191736004	DOID:10933
Insomnia	contraindication	193462001
Impaired renal function disorder	contraindication	197663003
Osteolysis	contraindication	203522001
Disease of liver	contraindication	235856003	DOID:409
Anemia	contraindication	271737000	DOID:2355
Pregnancy, function	contraindication	289908002
Thrombocytopenic disorder	contraindication	302215000	DOID:1588
Arteriosclerosis obliterans	contraindication	361133006	DOID:5160
Panic disorder	contraindication	371631005	DOID:594
Breastfeeding (mother)	contraindication	413712001
Myocardial ischemia	contraindication	414795007	DOID:3393
Myocardial infarction in recovery phase	contraindication	418044006
Acute erosive gastritis	contraindication	444926003

🐶 Veterinary Drug Use

None

🐶 Veterinary products

None

Acid dissociation constants calculated using MoKa v3.0.0

None

Orange Book patent data (new drug applications)

None

Orange Book exclusivity data (new drug applications)

Formulation strength	Trade name	Applicant	Application number	Approval date	Type	Dose form	Route	Exclusivity date	Description
1GM/10ML (100MG/ML)	CALCIUM GLUCONATE	NIVAGEN PHARMS INC	A213071	Oct. 14, 2022	RX	SOLUTION	INTRAVENOUS	May 5, 2023	COMPETITIVE GENERIC THERAPY

Bioactivity Summary:

None

External reference:

ID	Source
4018087	VUID
N0000146426	NUI
D00935	KEGG_DRUG
66905-23-5	SECONDARY_CAS_RN
4018087	VANDF
C0006699	UMLSCUI
CHEBI:3309	CHEBI
CHEMBL2106119	ChEMBL_ID
D002125	MESH_DESCRIPTOR_UI
DB11126	DRUGBANK_ID
SQE6VB453K	UNII
9290	PUBCHEM_CID
1298846	RXNORM
20	MMSL
4337	MMSL
71865	MMSL
d03800	MMSL
000777	NDDF
007049	NDDF
387292008	SNOMEDCT_US
53691001	SNOMEDCT_US

Pharmaceutical products:

Product	Category	Ingredients	NDC	Form	Quantity	Route	Marketing	Label
Calcium Gluconate	HUMAN PRESCRIPTION DRUG LABEL	1	0264-5600	INJECTION, SOLUTION	98 mg	INTRAVENOUS	ANDA	23 sections
Calgonate Calcium Gluconate Gel2.5%	HUMAN OTC DRUG LABEL	1	0295-7520	GEL	2.50 g	TOPICAL	unapproved drug other	8 sections
Calcium Gluconate	HUMAN PRESCRIPTION DRUG LABEL	1	0404-9831	INJECTION, SOLUTION	98 mg	INTRAVENOUS	NDA	16 sections
Calcium Gluconate	HUMAN PRESCRIPTION DRUG LABEL	1	0404-9831	INJECTION, SOLUTION	98 mg	INTRAVENOUS	NDA	16 sections
Dairy Allergen Mix	HUMAN OTC DRUG LABEL	38	43742-1277	LIQUID	6 [hp_C]	ORAL	unapproved drug other	9 sections
Calcium Gluconate	HUMAN PRESCRIPTION DRUG LABEL	1	44567-620	INJECTION, SOLUTION	20 mg	INTRAVENOUS	NDA	22 sections
Calcium Gluconate	HUMAN PRESCRIPTION DRUG LABEL	1	44567-621	INJECTION, SOLUTION	20 mg	INTRAVENOUS	NDA	22 sections
Calcium Gluconate	HUMAN PRESCRIPTION DRUG LABEL	1	44567-622	INJECTION, SOLUTION	10 mg	INTRAVENOUS	NDA	22 sections
Calcium Gluconate	Human Prescription Drug Label	1	50090-3398	INJECTION, SOLUTION	98 mg	INTRAVENOUS	NDA	23 sections
CALCIUM GLUCONATE	HUMAN PRESCRIPTION DRUG LABEL	1	51662-1312	INJECTION, SOLUTION	98 mg	INTRAVENOUS	NDA	17 sections
CALCIUM GLUCONATE	HUMAN PRESCRIPTION DRUG LABEL	1	51662-1312	INJECTION, SOLUTION	98 mg	INTRAVENOUS	NDA	17 sections
CALCIUM GLUCONATE	HUMAN PRESCRIPTION DRUG LABEL	1	51662-1347	INJECTION, SOLUTION	98 mg	INTRAVENOUS	NDA	17 sections
CALCIUM GLUCONATE	HUMAN PRESCRIPTION DRUG LABEL	1	51662-1347	INJECTION, SOLUTION	98 mg	INTRAVENOUS	NDA	17 sections
Calcium Gluconate	HUMAN PRESCRIPTION DRUG LABEL	1	52584-360	INJECTION, SOLUTION	98 mg	INTRAVENOUS	NDA	15 sections
Calcium Gluconate	HUMAN PRESCRIPTION DRUG LABEL	1	52584-360	INJECTION, SOLUTION	98 mg	INTRAVENOUS	NDA	15 sections
Calcium Gluconate	HUMAN PRESCRIPTION DRUG LABEL	1	63323-360	INJECTION, SOLUTION	98 mg	INTRAVENOUS	NDA	26 sections
Calcium Gluconate	HUMAN PRESCRIPTION DRUG LABEL	1	63323-360	INJECTION, SOLUTION	98 mg	INTRAVENOUS	NDA	26 sections
Calcium Gluconate	HUMAN PRESCRIPTION DRUG LABEL	1	65219-162	INJECTION, SOLUTION	20 mg	INTRAVENOUS	NDA	23 sections
Calcium Gluconate	HUMAN PRESCRIPTION DRUG LABEL	1	65219-162	INJECTION, SOLUTION	20 mg	INTRAVENOUS	NDA	23 sections
Calcium Gluconate	HUMAN PRESCRIPTION DRUG LABEL	1	65219-164	INJECTION, SOLUTION	20 mg	INTRAVENOUS	NDA	23 sections
Calcium Gluconate	HUMAN PRESCRIPTION DRUG LABEL	1	65219-164	INJECTION, SOLUTION	20 mg	INTRAVENOUS	NDA	23 sections
Calcium Gluconate	HUMAN PRESCRIPTION DRUG LABEL	1	71872-7222	INJECTION, SOLUTION	98 mg	INTRAVENOUS	NDA	23 sections
Calcium Gluconate	HUMAN PRESCRIPTION DRUG LABEL	1	71872-7222	INJECTION, SOLUTION	98 mg	INTRAVENOUS	NDA	23 sections
calcium gluconate	Human Prescription Drug Label	1	75834-171	INJECTION, SOLUTION	98 mg	INTRAVENOUS	ANDA	23 sections