calcium gluconate 🐶 Veterinary Use | Indications/Contra | FAERs-F | FAERs-M | Orange Bk | BioActivity |

Stem definition	Drug id	CAS RN
	4348	299-28-5

Description:

Molecule	Description
Synonyms: calcium gluconate calciofon Calcium D-gluconate calcium gluconate monohydrate	The calcium salt of gluconic acid. The compound has a variety of uses, including its use as a calcium replenisher in hypocalcemic states. Molecular weight: 430.37 Formula: C12H22CaO14 CLOGP: LIPINSKI: None HAC: None HDO: None TPSA: 141.28 ALOGS: ROTB: None

Molecule

Description

Synonyms:

calcium gluconate
calciofon
Calcium D-gluconate
calcium gluconate monohydrate

The calcium salt of gluconic acid. The compound has a variety of uses, including its use as a calcium replenisher in hypocalcemic states.

Molecular weight: 430.37
Formula: C12H22CaO14
CLOGP:
LIPINSKI: None
HAC: None
HDO: None
TPSA: 141.28
ALOGS:
ROTB: None

Drug dosage:

Dose	Unit	Route
3	g	O
3	g	P

ADMET properties:

None

Approvals:

Date	Agency	Company	Orphan
None	FDA

FDA Adverse Event Reporting System (Female)

MedDRA adverse event term	Likelihood ratio	Likelihood ratio threshold	Patients taking drug having adverse event	Patients taking drug not having adverse event	Patients not taking drug having adverse event	Patients not taking drug not having adverse event
Liver injury	213.91	12.76	124	17721	24682	50562597
Psoriatic arthropathy	134.37	12.76	120	17725	46912	50540367
Product complaint	82.38	12.76	51	17794	11415	50575864
Glossodynia	53.82	12.76	123	17722	115446	50471833
Hypocalcaemia	47.86	12.76	53	17792	26763	50560516
Pemphigus	47.46	12.76	120	17725	120046	50467233
Systemic lupus erythematosus	44.10	12.76	129	17716	140493	50446786
Alopecia	42.51	12.76	185	17660	244862	50342417
Arthropathy	42.21	12.76	137	17708	157769	50429510
Rheumatoid arthritis	39.88	12.76	159	17686	202391	50384888
Hypercalcaemia	38.01	12.76	44	17801	23308	50563971
Skin reaction	35.97	12.76	31	17814	11537	50575742
Posthaemorrhagic hydrocephalus	33.39	12.76	6	17839	18	50587261
Blood calcium increased	33.17	12.76	25	17820	7694	50579585
Product use issue	30.74	12.76	119	17726	149356	50437923
Recalled product	30.61	12.76	13	17832	1322	50585957
Contraindicated product administered	29.34	12.76	117	17728	148841	50438438
Cystic fibrosis	29.22	12.76	16	17829	2848	50584431
Multiple drug therapy	28.97	12.76	14	17831	1923	50585356
Live birth	28.54	12.76	32	17813	16376	50570903
Abdominal discomfort	26.77	12.76	156	17689	231485	50355794
Product dose omission issue	26.51	12.76	16	17829	183822	50403457
Distributive shock	25.49	12.76	10	17835	830	50586449
Product compounding quality issue	25.18	12.76	5	17840	29	50587250
Hiccups	24.30	12.76	12	17833	1727	50585552
Endometritis	24.05	12.76	10	17835	965	50586314
Culture positive	24.05	12.76	8	17837	413	50586866
Suspected transmission of an infectious agent via product	23.99	12.76	7	17838	233	50587046
Haemodynamic instability	23.93	12.76	21	17824	8003	50579276
Mucous stools	23.65	12.76	14	17831	2888	50584391
Amnesia	23.08	12.76	48	17797	42212	50545067
Neonatal infection	22.89	12.76	6	17839	133	50587146
Nail infection	22.83	12.76	12	17833	1969	50585310
Hyperdynamic left ventricle	22.40	12.76	6	17839	145	50587134
Exercise tolerance decreased	21.42	12.76	16	17829	4858	50582421
Maternal exposure during pregnancy	21.38	12.76	112	17733	159666	50427613
Electrocardiogram U wave present	20.17	12.76	5	17840	88	50587191
Rheumatic fever	19.81	12.76	27	17818	16840	50570439
Pancreatitis chronic	18.86	12.76	11	17834	2209	50585070
Hypokalaemia	18.85	12.76	71	17774	87921	50499358
Colour blindness	18.60	12.76	6	17839	281	50586998
Multiple organ dysfunction syndrome	18.53	12.76	49	17796	50288	50536991
Cytotoxic oedema	18.43	12.76	5	17840	127	50587152
Blood pressure inadequately controlled	18.41	12.76	14	17831	4366	50582913
CSF pressure increased	18.39	12.76	5	17840	128	50587151
Terminal ileitis	17.58	12.76	7	17838	604	50586675
Poor peripheral circulation	17.47	12.76	12	17833	3196	50584083
Colitis ischaemic	17.36	12.76	19	17826	9464	50577815
Hypertension	16.98	12.76	130	17715	211073	50376206
Diabetes mellitus inadequate control	16.91	12.76	22	17823	13123	50574156
Laryngeal pain	16.73	12.76	13	17832	4186	50583093
Toxic epidermal necrolysis	16.67	12.76	28	17817	20964	50566315
Metabolic acidosis	16.60	12.76	40	17805	38785	50548494
Septic shock	16.52	12.76	51	17794	57124	50530155
Weight increased	16.20	12.76	29	17816	201862	50385417
Electrocardiogram P wave abnormal	16.14	12.76	5	17840	205	50587074
Blood cholesterol increased	14.80	12.76	48	17797	55167	50532112
Retinal ischaemia	13.99	12.76	5	17840	320	50586959
Ileus	13.79	12.76	20	17825	13209	50574070
Electrocardiogram T wave amplitude decreased	13.69	12.76	5	17840	341	50586938
Prescribed overdose	13.68	12.76	21	17824	14579	50572700
Small intestinal obstruction	13.52	12.76	22	17823	16046	50571233
Optic atrophy	13.51	12.76	7	17838	1115	50586164
Discomfort	13.15	12.76	74	17771	108306	50478973
Pantoea agglomerans infection	12.95	12.76	3	17842	39	50587240
Blindness cortical	12.91	12.76	5	17840	401	50586878
Anal incontinence	12.90	12.76	18	17827	11472	50575807

FDA Adverse Event Reporting System (Male)

MedDRA adverse event term	Likelihood ratio	Likelihood ratio threshold	Patients taking drug having adverse event	Patients taking drug not having adverse event	Patients not taking drug having adverse event	Patients not taking drug not having adverse event
Toxic epidermal necrolysis	128.02	15.19	71	7443	18082	29548931
Lymphocyte count decreased	66.59	15.19	48	7466	19223	29547790
Hypocalcaemia	44.53	15.19	39	7475	20626	29546387
Cytokine release syndrome	43.77	15.19	32	7482	13087	29553926
Hypokalaemia	35.35	15.19	53	7461	50150	29516863
Red blood cells urine positive	31.90	15.19	13	7501	1660	29565353
Incision site pain	31.10	15.19	13	7501	1770	29565243
Blood urea increased	29.43	15.19	36	7478	28076	29538937
Protein urine present	29.38	15.19	17	7497	4677	29562336
Procedural pain	28.25	15.19	16	7498	4228	29562785
Neutrophil count increased	28.16	15.19	26	7488	14716	29552297
Benign abdominal neoplasm	27.06	15.19	6	7508	90	29566923
Posthaemorrhagic hydrocephalus	26.76	15.19	6	7508	95	29566918
Herpes zoster reactivation	25.45	15.19	7	7507	263	29566750
Wrong patient	25.34	15.19	6	7508	122	29566891
Product preparation error	25.29	15.19	11	7503	1651	29565362
Chest expansion decreased	24.20	15.19	6	7508	149	29566864
Hyperkalaemia	23.92	15.19	50	7464	61342	29505671
Immune effector cell-associated neurotoxicity syndrome	22.91	15.19	10	7504	1514	29565499
Hypotension	22.30	15.19	103	7411	194251	29372762
Blood creatinine increased	21.94	15.19	59	7455	85043	29481970
Scrotal pain	21.63	15.19	8	7506	788	29566225
Axial spondyloarthritis	20.79	15.19	6	7508	269	29566744
Lactobacillus test positive	20.68	15.19	4	7510	29	29566984
Delayed graft function	20.66	15.19	10	7504	1917	29565096
Pantoea agglomerans infection	19.91	15.19	4	7510	36	29566977
Multiple organ dysfunction syndrome	19.64	15.19	47	7467	63069	29503944
Blood albumin decreased	19.24	15.19	19	7495	11676	29555337
Cardiac arrest	18.80	15.19	56	7458	85535	29481478
Hypothalamo-pituitary disorder	18.43	15.19	7	7507	742	29566271
Respiratory failure	18.07	15.19	60	7454	97071	29469942
Hypoxia	17.77	15.19	38	7476	47341	29519672
White blood cell count increased	17.55	15.19	33	7481	37483	29529530
Cyanosis	16.16	15.19	17	7497	11250	29555763
Hypercalcaemia	16.11	15.19	18	7496	12741	29554272
Sepsis	15.88	15.19	75	7439	142607	29424406
Acute kidney injury	15.66	15.19	118	7396	265149	29301864
Bacteraemia	15.63	15.19	20	7494	16303	29550710
Oesophagitis	15.37	15.19	17	7497	11906	29555107
Lactobacillus infection	15.31	15.19	4	7510	123	29566890

FDA Adverse Event Reporting System (Geriatric)

MedDRA adverse event term	Likelihood ratio	Likelihood ratio threshold	Patients taking drug having adverse event	Patients taking drug not having adverse event	Patients not taking drug having adverse event	Patients not taking drug not having adverse event
Toxic epidermal necrolysis	126.66	12.26	98	19184	37068	64442382
Product complaint	99.00	12.26	55	19227	11899	64467551
Hypocalcaemia	77.52	12.26	78	19204	41675	64437775
Hypercalcaemia	51.66	12.26	55	19227	31361	64448089
Completed suicide	49.21	12.26	5	19277	224409	64255041
Hypokalaemia	45.91	12.26	108	19174	121795	64357655
Blood calcium increased	41.62	12.26	28	19254	8514	64470936
Lymphocyte count decreased	37.20	12.26	53	19229	40646	64438804
Incision site pain	35.90	12.26	17	19265	2637	64476813
Multiple organ dysfunction syndrome	32.00	12.26	84	19198	101329	64378121
Culture positive	31.91	12.26	12	19270	1050	64478400
Blood urea increased	31.17	12.26	51	19231	44102	64435348
Recalled product	29.87	12.26	11	19271	908	64478542
Suspected transmission of an infectious agent via product	29.87	12.26	11	19271	908	64478542
Rheumatic fever	28.40	12.26	23	19259	9271	64470179
Endometritis	28.00	12.26	10	19272	756	64478694
Red blood cells urine positive	27.55	12.26	17	19265	4461	64474989
Pantoea agglomerans infection	27.18	12.26	6	19276	74	64479376
Protein urine present	27.02	12.26	22	19260	8934	64470516
Cytokine release syndrome	26.62	12.26	32	19250	20797	64458653
Neutrophil count increased	26.34	12.26	35	19247	25139	64454311
Multiple drug therapy	26.15	12.26	13	19269	2241	64477209
Nail infection	25.50	12.26	12	19270	1835	64477615
Small for dates baby	25.01	12.26	8	19274	431	64479019
Live birth	24.67	12.26	23	19259	11181	64468269
Poor peripheral circulation	24.53	12.26	14	19268	3186	64476264
Product compounding quality issue	24.39	12.26	5	19277	42	64479408
Drug abuse	24.26	12.26	5	19277	132369	64347081
Product dose omission issue	22.93	12.26	15	19267	194732	64284718
Haemodynamic instability	22.57	12.26	25	19257	14887	64464563
Distributive shock	22.31	12.26	11	19271	1864	64477586
Chest expansion decreased	21.86	12.26	6	19276	189	64479261
Acute respiratory distress syndrome	21.04	12.26	40	19242	38895	64440555
Benign abdominal neoplasm	20.83	12.26	6	19276	226	64479224
Lactobacillus test positive	19.91	12.26	4	19278	30	64479420
Delayed graft function	19.89	12.26	12	19270	3024	64476426
Hyperkalaemia	19.89	12.26	71	19211	101058	64378392
Electrocardiogram U wave present	19.64	12.26	5	19277	117	64479333
Hyperdynamic left ventricle	19.49	12.26	6	19276	285	64479165
Hypophosphataemia	19.45	12.26	23	19259	14697	64464753
Metabolic acidosis	18.64	12.26	55	19227	70903	64408547
Blood albumin decreased	18.61	12.26	27	19255	21046	64458404
Aspartate aminotransferase increased	18.58	12.26	78	19204	119710	64359740
Blood cholesterol increased	18.44	12.26	44	19238	50022	64429428
Colitis ischaemic	17.79	12.26	21	19261	13393	64466057
Colour blindness	17.75	12.26	6	19276	385	64479065
Hypoalbuminaemia	17.62	12.26	24	19258	17650	64461800
Axial spondyloarthritis	17.50	12.26	6	19276	402	64479048
Alanine aminotransferase increased	17.42	12.26	85	19197	138946	64340504
Septic shock	17.41	12.26	70	19212	105367	64374083
Swollen joint count increased	17.35	12.26	16	19266	7673	64471777
Exercise tolerance decreased	17.31	12.26	16	19266	7694	64471756
Vaginal discharge	16.88	12.26	12	19270	3985	64475465
Ileus	16.85	12.26	27	19255	22939	64456511
Sepsis	16.71	12.26	122	19160	230219	64249231
CSF pressure increased	16.66	12.26	5	19277	218	64479232
Blood creatinine increased	16.29	12.26	82	19200	135700	64343750
Cardiovascular insufficiency	16.24	12.26	10	19272	2614	64476836
Blood pressure inadequately controlled	15.77	12.26	13	19269	5371	64474079
Electrocardiogram T wave amplitude decreased	15.59	12.26	6	19276	559	64478891
Burkholderia test positive	15.45	12.26	6	19276	573	64478877
Procedural pain	15.37	12.26	21	19261	15487	64463963
White blood cell count increased	15.32	12.26	49	19233	65965	64413485
Electrocardiogram P wave abnormal	15.26	12.26	5	19277	291	64479159
Laryngeal pain	15.19	12.26	13	19269	5655	64473795
Blood triglycerides increased	14.98	12.26	23	19259	18843	64460607
Fall	14.91	12.26	69	19213	416757	64062693
Paraesthesia oral	14.89	12.26	19	19263	13112	64466338
Terminal ileitis	14.87	12.26	6	19276	634	64478816
Cytotoxic oedema	14.85	12.26	5	19277	317	64479133
Weight increased	14.49	12.26	26	19256	213322	64266128
Hiccups	14.36	12.26	15	19267	8361	64471089
Death	13.88	12.26	86	19196	482619	63996831
Respiratory failure	13.84	12.26	89	19193	161094	64318356
Pulseless electrical activity	13.77	12.26	18	19264	12721	64466729
Pulmonary oedema	13.60	12.26	53	19229	78621	64400829
Pancreatitis chronic	13.40	12.26	10	19272	3576	64475874
Stillbirth	13.29	12.26	10	19272	3623	64475827
Tumour lysis syndrome	13.10	12.26	22	19260	19418	64460032
Blood glucose increased	13.04	12.26	61	19221	98012	64381438
Lactobacillus infection	12.95	12.26	4	19278	192	64479258
Liver injury	12.90	12.26	28	19254	29904	64449546
Tetany	12.74	12.26	8	19274	2164	64477286
Hypoxia	12.59	12.26	56	19226	88093	64391357
Bilirubin conjugated increased	12.51	12.26	11	19271	4957	64474493
Toxicity to various agents	12.51	12.26	61	19221	363452	64115998
Cyanosis	12.26	12.26	23	19259	22132	64457318

FDA Adverse Event Reporting System (Pediatric)

None

Pharmacologic Action:

Source	Code	Description
ATC	A12AA03	ALIMENTARY TRACT AND METABOLISM MINERAL SUPPLEMENTS CALCIUM Calcium
ATC	D11AX03	DERMATOLOGICALS OTHER DERMATOLOGICAL PREPARATIONS OTHER DERMATOLOGICAL PREPARATIONS Other dermatologicals
CHEBI has role	CHEBI:50733	Dietary Supplement

Drug Use | Suggest Off label Use Form| |View source of the data|

Disease	Relation	SNOMED_ID	DOID
Hypocalcemia	indication	5291005
Osteoporosis	indication	64859006	DOID:11476
Hypocalcemic tetany	indication	190869004
Necrotizing enterocolitis in fetus OR newborn	contraindication	2707005
Alcoholism	contraindication	7200002
Poisoning by digitalis glycoside	contraindication	12876009
Peptic ulcer	contraindication	13200003	DOID:750
Constipation	contraindication	14760008	DOID:2089
Hyperphosphatemia	contraindication	20165001	DOID:0050459
Hypervitaminosis D	contraindication	27712000	DOID:9971
Sarcoidosis	contraindication	31541009	DOID:11335
Dehydration	contraindication	34095006
Hypertensive disorder	contraindication	38341003	DOID:10763
Gastrointestinal ulcer	contraindication	40845000
Conduction disorder of the heart	contraindication	44808001
End stage renal disease	contraindication	46177005	DOID:784
Humoral hypercalcemia of malignancy	contraindication	47709007
Vitamin K deficiency	contraindication	52675005	DOID:11249
Nasal polyp	contraindication	52756005
Heart disease	contraindication	56265001	DOID:114
Acute nephropathy	contraindication	58574008
Hepatic failure	contraindication	59927004
Hypercalcemia	contraindication	66931009	DOID:12678
Hyperparathyroidism	contraindication	66999008	DOID:13543
Poisoning by acetaminophen	contraindication	70273001
Agoraphobia	contraindication	70691001	DOID:593
Ventricular fibrillation	contraindication	71908006
Hypercalciuria	contraindication	71938000
Factor II deficiency	contraindication	73975000
Reye's syndrome	contraindication	74351001	DOID:14525
Gastrointestinal hemorrhage	contraindication	74474003
Thrombotic thrombocytopenic purpura	contraindication	78129009	DOID:10772
Gout	contraindication	90560007	DOID:13189
Kidney disease	contraindication	90708001	DOID:557
Hemophilia	contraindication	90935002
Kidney stone	contraindication	95570007
Anemia due to enzyme deficiency	contraindication	111577008
von Willebrand disorder	contraindication	128105004	DOID:12531
Seizure disorder	contraindication	128613002
Obsessive-compulsive disorder	contraindication	191736004	DOID:10933
Insomnia	contraindication	193462001
Impaired renal function disorder	contraindication	197663003
Osteolysis	contraindication	203522001
Disease of liver	contraindication	235856003	DOID:409
Anemia	contraindication	271737000	DOID:2355
Pregnancy, function	contraindication	289908002
Thrombocytopenic disorder	contraindication	302215000	DOID:1588
Arteriosclerosis obliterans	contraindication	361133006	DOID:5160
Panic disorder	contraindication	371631005	DOID:594
Breastfeeding (mother)	contraindication	413712001
Myocardial ischemia	contraindication	414795007	DOID:3393
Myocardial infarction in recovery phase	contraindication	418044006
Acute erosive gastritis	contraindication	444926003

🐶 Veterinary Drug Use

None

🐶 Veterinary products

None

Acid dissociation constants calculated using MoKa v3.0.0

None

Orange Book patent data (new drug applications)

None

Orange Book exclusivity data (new drug applications)

None

Bioactivity Summary:

None

External reference:

ID	Source
4018087	VUID
N0000146426	NUI
D00935	KEGG_DRUG
66905-23-5	SECONDARY_CAS_RN
4018087	VANDF
C0006699	UMLSCUI
CHEBI:3309	CHEBI
CHEMBL2106119	ChEMBL_ID
D002125	MESH_DESCRIPTOR_UI
DB11126	DRUGBANK_ID
SQE6VB453K	UNII
9290	PUBCHEM_CID
1298846	RXNORM
20	MMSL
4337	MMSL
71865	MMSL
d03800	MMSL
000777	NDDF
007049	NDDF
387292008	SNOMEDCT_US
53691001	SNOMEDCT_US

Pharmaceutical products:

Product	Category	Ingredients	NDC	Form	Quantity	Route	Marketing	Label
Calgonate Calcium Gluconate Gel2.5%	HUMAN OTC DRUG LABEL	1	0295-7520	GEL	2.50 g	TOPICAL	unapproved drug other	8 sections
Calcium Gluconate	HUMAN PRESCRIPTION DRUG LABEL	1	0404-9831	INJECTION, SOLUTION	98 mg	INTRAVENOUS	NDA	15 sections
Dairy Allergen Mix	HUMAN OTC DRUG LABEL	38	43742-1277	LIQUID	6 [hp_C]	ORAL	unapproved drug other	9 sections
Calcium Gluconate	HUMAN PRESCRIPTION DRUG LABEL	1	44567-620	INJECTION, SOLUTION	20 mg	INTRAVENOUS	NDA	22 sections
Calcium Gluconate	HUMAN PRESCRIPTION DRUG LABEL	1	44567-621	INJECTION, SOLUTION	20 mg	INTRAVENOUS	NDA	22 sections
Calcium Gluconate	HUMAN PRESCRIPTION DRUG LABEL	1	44567-622	INJECTION, SOLUTION	10 mg	INTRAVENOUS	NDA	22 sections
Calcium Gluconate	Human Prescription Drug Label	1	50090-3398	INJECTION, SOLUTION	98 mg	INTRAVENOUS	NDA	23 sections
CALCIUM GLUCONATE	HUMAN PRESCRIPTION DRUG LABEL	1	51662-1312	INJECTION, SOLUTION	98 mg	INTRAVENOUS	NDA	17 sections
CALCIUM GLUCONATE	HUMAN PRESCRIPTION DRUG LABEL	1	51662-1347	INJECTION, SOLUTION	98 mg	INTRAVENOUS	NDA	17 sections
Calcium Gluconate	HUMAN PRESCRIPTION DRUG LABEL	1	52584-360	INJECTION, SOLUTION	98 mg	INTRAVENOUS	NDA	15 sections
Calcium Gluconate	HUMAN PRESCRIPTION DRUG LABEL	1	63323-360	INJECTION, SOLUTION	98 mg	INTRAVENOUS	NDA	23 sections
Calcium Gluconate	HUMAN PRESCRIPTION DRUG LABEL	1	65219-162	INJECTION, SOLUTION	20 mg	INTRAVENOUS	NDA	23 sections
Calcium Gluconate	HUMAN PRESCRIPTION DRUG LABEL	1	65219-164	INJECTION, SOLUTION	20 mg	INTRAVENOUS	NDA	23 sections
Calcium Gluconate	HUMAN PRESCRIPTION DRUG LABEL	1	71872-7222	INJECTION, SOLUTION	98 mg	INTRAVENOUS	NDA	23 sections