calcium gluconate 🐶 Veterinary Use | Indications/Contra | FAERs-F | FAERs-M | Orange Bk | BioActivity |

Stem definitionDrug idCAS RN
4348 299-28-5

Description:

MoleculeDescription

Synonyms:

  • calcium gluconate
  • calciofon
  • Calcium D-gluconate
  • calcium gluconate monohydrate
The calcium salt of gluconic acid. The compound has a variety of uses, including its use as a calcium replenisher in hypocalcemic states.
  • Molecular weight: 430.37
  • Formula: C12H22CaO14
  • CLOGP:
  • LIPINSKI: None
  • HAC: None
  • HDO: None
  • TPSA: 141.28
  • ALOGS:
  • ROTB: None

Drug dosage:

DoseUnitRoute
3 g O
3 g P

ADMET properties:

None

Approvals:

DateAgencyCompanyOrphan
None FDA

FDA Adverse Event Reporting System (Female)

MedDRA adverse event termLikelihood ratioLikelihood ratio thresholdPatients taking drug having adverse eventPatients taking drug not having adverse eventPatients not taking drug having adverse eventPatients not taking drug not having adverse event
Liver injury 213.91 12.76 124 17721 24682 50562597
Psoriatic arthropathy 134.37 12.76 120 17725 46912 50540367
Product complaint 82.38 12.76 51 17794 11415 50575864
Glossodynia 53.82 12.76 123 17722 115446 50471833
Hypocalcaemia 47.86 12.76 53 17792 26763 50560516
Pemphigus 47.46 12.76 120 17725 120046 50467233
Systemic lupus erythematosus 44.10 12.76 129 17716 140493 50446786
Alopecia 42.51 12.76 185 17660 244862 50342417
Arthropathy 42.21 12.76 137 17708 157769 50429510
Rheumatoid arthritis 39.88 12.76 159 17686 202391 50384888
Hypercalcaemia 38.01 12.76 44 17801 23308 50563971
Skin reaction 35.97 12.76 31 17814 11537 50575742
Posthaemorrhagic hydrocephalus 33.39 12.76 6 17839 18 50587261
Blood calcium increased 33.17 12.76 25 17820 7694 50579585
Product use issue 30.74 12.76 119 17726 149356 50437923
Recalled product 30.61 12.76 13 17832 1322 50585957
Contraindicated product administered 29.34 12.76 117 17728 148841 50438438
Cystic fibrosis 29.22 12.76 16 17829 2848 50584431
Multiple drug therapy 28.97 12.76 14 17831 1923 50585356
Live birth 28.54 12.76 32 17813 16376 50570903
Abdominal discomfort 26.77 12.76 156 17689 231485 50355794
Product dose omission issue 26.51 12.76 16 17829 183822 50403457
Distributive shock 25.49 12.76 10 17835 830 50586449
Product compounding quality issue 25.18 12.76 5 17840 29 50587250
Hiccups 24.30 12.76 12 17833 1727 50585552
Endometritis 24.05 12.76 10 17835 965 50586314
Culture positive 24.05 12.76 8 17837 413 50586866
Suspected transmission of an infectious agent via product 23.99 12.76 7 17838 233 50587046
Haemodynamic instability 23.93 12.76 21 17824 8003 50579276
Mucous stools 23.65 12.76 14 17831 2888 50584391
Amnesia 23.08 12.76 48 17797 42212 50545067
Neonatal infection 22.89 12.76 6 17839 133 50587146
Nail infection 22.83 12.76 12 17833 1969 50585310
Hyperdynamic left ventricle 22.40 12.76 6 17839 145 50587134
Exercise tolerance decreased 21.42 12.76 16 17829 4858 50582421
Maternal exposure during pregnancy 21.38 12.76 112 17733 159666 50427613
Electrocardiogram U wave present 20.17 12.76 5 17840 88 50587191
Rheumatic fever 19.81 12.76 27 17818 16840 50570439
Pancreatitis chronic 18.86 12.76 11 17834 2209 50585070
Hypokalaemia 18.85 12.76 71 17774 87921 50499358
Colour blindness 18.60 12.76 6 17839 281 50586998
Multiple organ dysfunction syndrome 18.53 12.76 49 17796 50288 50536991
Cytotoxic oedema 18.43 12.76 5 17840 127 50587152
Blood pressure inadequately controlled 18.41 12.76 14 17831 4366 50582913
CSF pressure increased 18.39 12.76 5 17840 128 50587151
Terminal ileitis 17.58 12.76 7 17838 604 50586675
Poor peripheral circulation 17.47 12.76 12 17833 3196 50584083
Colitis ischaemic 17.36 12.76 19 17826 9464 50577815
Hypertension 16.98 12.76 130 17715 211073 50376206
Diabetes mellitus inadequate control 16.91 12.76 22 17823 13123 50574156
Laryngeal pain 16.73 12.76 13 17832 4186 50583093
Toxic epidermal necrolysis 16.67 12.76 28 17817 20964 50566315
Metabolic acidosis 16.60 12.76 40 17805 38785 50548494
Septic shock 16.52 12.76 51 17794 57124 50530155
Weight increased 16.20 12.76 29 17816 201862 50385417
Electrocardiogram P wave abnormal 16.14 12.76 5 17840 205 50587074
Blood cholesterol increased 14.80 12.76 48 17797 55167 50532112
Retinal ischaemia 13.99 12.76 5 17840 320 50586959
Ileus 13.79 12.76 20 17825 13209 50574070
Electrocardiogram T wave amplitude decreased 13.69 12.76 5 17840 341 50586938
Prescribed overdose 13.68 12.76 21 17824 14579 50572700
Small intestinal obstruction 13.52 12.76 22 17823 16046 50571233
Optic atrophy 13.51 12.76 7 17838 1115 50586164
Discomfort 13.15 12.76 74 17771 108306 50478973
Pantoea agglomerans infection 12.95 12.76 3 17842 39 50587240
Blindness cortical 12.91 12.76 5 17840 401 50586878
Anal incontinence 12.90 12.76 18 17827 11472 50575807

FDA Adverse Event Reporting System (Male)

MedDRA adverse event termLikelihood ratioLikelihood ratio thresholdPatients taking drug having adverse eventPatients taking drug not having adverse eventPatients not taking drug having adverse eventPatients not taking drug not having adverse event
Toxic epidermal necrolysis 128.02 15.19 71 7443 18082 29548931
Lymphocyte count decreased 66.59 15.19 48 7466 19223 29547790
Hypocalcaemia 44.53 15.19 39 7475 20626 29546387
Cytokine release syndrome 43.77 15.19 32 7482 13087 29553926
Hypokalaemia 35.35 15.19 53 7461 50150 29516863
Red blood cells urine positive 31.90 15.19 13 7501 1660 29565353
Incision site pain 31.10 15.19 13 7501 1770 29565243
Blood urea increased 29.43 15.19 36 7478 28076 29538937
Protein urine present 29.38 15.19 17 7497 4677 29562336
Procedural pain 28.25 15.19 16 7498 4228 29562785
Neutrophil count increased 28.16 15.19 26 7488 14716 29552297
Benign abdominal neoplasm 27.06 15.19 6 7508 90 29566923
Posthaemorrhagic hydrocephalus 26.76 15.19 6 7508 95 29566918
Herpes zoster reactivation 25.45 15.19 7 7507 263 29566750
Wrong patient 25.34 15.19 6 7508 122 29566891
Product preparation error 25.29 15.19 11 7503 1651 29565362
Chest expansion decreased 24.20 15.19 6 7508 149 29566864
Hyperkalaemia 23.92 15.19 50 7464 61342 29505671
Immune effector cell-associated neurotoxicity syndrome 22.91 15.19 10 7504 1514 29565499
Hypotension 22.30 15.19 103 7411 194251 29372762
Blood creatinine increased 21.94 15.19 59 7455 85043 29481970
Scrotal pain 21.63 15.19 8 7506 788 29566225
Axial spondyloarthritis 20.79 15.19 6 7508 269 29566744
Lactobacillus test positive 20.68 15.19 4 7510 29 29566984
Delayed graft function 20.66 15.19 10 7504 1917 29565096
Pantoea agglomerans infection 19.91 15.19 4 7510 36 29566977
Multiple organ dysfunction syndrome 19.64 15.19 47 7467 63069 29503944
Blood albumin decreased 19.24 15.19 19 7495 11676 29555337
Cardiac arrest 18.80 15.19 56 7458 85535 29481478
Hypothalamo-pituitary disorder 18.43 15.19 7 7507 742 29566271
Respiratory failure 18.07 15.19 60 7454 97071 29469942
Hypoxia 17.77 15.19 38 7476 47341 29519672
White blood cell count increased 17.55 15.19 33 7481 37483 29529530
Cyanosis 16.16 15.19 17 7497 11250 29555763
Hypercalcaemia 16.11 15.19 18 7496 12741 29554272
Sepsis 15.88 15.19 75 7439 142607 29424406
Acute kidney injury 15.66 15.19 118 7396 265149 29301864
Bacteraemia 15.63 15.19 20 7494 16303 29550710
Oesophagitis 15.37 15.19 17 7497 11906 29555107
Lactobacillus infection 15.31 15.19 4 7510 123 29566890

FDA Adverse Event Reporting System (Geriatric)

MedDRA adverse event termLikelihood ratioLikelihood ratio thresholdPatients taking drug having adverse eventPatients taking drug not having adverse eventPatients not taking drug having adverse eventPatients not taking drug not having adverse event
Toxic epidermal necrolysis 126.66 12.26 98 19184 37068 64442382
Product complaint 99.00 12.26 55 19227 11899 64467551
Hypocalcaemia 77.52 12.26 78 19204 41675 64437775
Hypercalcaemia 51.66 12.26 55 19227 31361 64448089
Completed suicide 49.21 12.26 5 19277 224409 64255041
Hypokalaemia 45.91 12.26 108 19174 121795 64357655
Blood calcium increased 41.62 12.26 28 19254 8514 64470936
Lymphocyte count decreased 37.20 12.26 53 19229 40646 64438804
Incision site pain 35.90 12.26 17 19265 2637 64476813
Multiple organ dysfunction syndrome 32.00 12.26 84 19198 101329 64378121
Culture positive 31.91 12.26 12 19270 1050 64478400
Blood urea increased 31.17 12.26 51 19231 44102 64435348
Recalled product 29.87 12.26 11 19271 908 64478542
Suspected transmission of an infectious agent via product 29.87 12.26 11 19271 908 64478542
Rheumatic fever 28.40 12.26 23 19259 9271 64470179
Endometritis 28.00 12.26 10 19272 756 64478694
Red blood cells urine positive 27.55 12.26 17 19265 4461 64474989
Pantoea agglomerans infection 27.18 12.26 6 19276 74 64479376
Protein urine present 27.02 12.26 22 19260 8934 64470516
Cytokine release syndrome 26.62 12.26 32 19250 20797 64458653
Neutrophil count increased 26.34 12.26 35 19247 25139 64454311
Multiple drug therapy 26.15 12.26 13 19269 2241 64477209
Nail infection 25.50 12.26 12 19270 1835 64477615
Small for dates baby 25.01 12.26 8 19274 431 64479019
Live birth 24.67 12.26 23 19259 11181 64468269
Poor peripheral circulation 24.53 12.26 14 19268 3186 64476264
Product compounding quality issue 24.39 12.26 5 19277 42 64479408
Drug abuse 24.26 12.26 5 19277 132369 64347081
Product dose omission issue 22.93 12.26 15 19267 194732 64284718
Haemodynamic instability 22.57 12.26 25 19257 14887 64464563
Distributive shock 22.31 12.26 11 19271 1864 64477586
Chest expansion decreased 21.86 12.26 6 19276 189 64479261
Acute respiratory distress syndrome 21.04 12.26 40 19242 38895 64440555
Benign abdominal neoplasm 20.83 12.26 6 19276 226 64479224
Lactobacillus test positive 19.91 12.26 4 19278 30 64479420
Delayed graft function 19.89 12.26 12 19270 3024 64476426
Hyperkalaemia 19.89 12.26 71 19211 101058 64378392
Electrocardiogram U wave present 19.64 12.26 5 19277 117 64479333
Hyperdynamic left ventricle 19.49 12.26 6 19276 285 64479165
Hypophosphataemia 19.45 12.26 23 19259 14697 64464753
Metabolic acidosis 18.64 12.26 55 19227 70903 64408547
Blood albumin decreased 18.61 12.26 27 19255 21046 64458404
Aspartate aminotransferase increased 18.58 12.26 78 19204 119710 64359740
Blood cholesterol increased 18.44 12.26 44 19238 50022 64429428
Colitis ischaemic 17.79 12.26 21 19261 13393 64466057
Colour blindness 17.75 12.26 6 19276 385 64479065
Hypoalbuminaemia 17.62 12.26 24 19258 17650 64461800
Axial spondyloarthritis 17.50 12.26 6 19276 402 64479048
Alanine aminotransferase increased 17.42 12.26 85 19197 138946 64340504
Septic shock 17.41 12.26 70 19212 105367 64374083
Swollen joint count increased 17.35 12.26 16 19266 7673 64471777
Exercise tolerance decreased 17.31 12.26 16 19266 7694 64471756
Vaginal discharge 16.88 12.26 12 19270 3985 64475465
Ileus 16.85 12.26 27 19255 22939 64456511
Sepsis 16.71 12.26 122 19160 230219 64249231
CSF pressure increased 16.66 12.26 5 19277 218 64479232
Blood creatinine increased 16.29 12.26 82 19200 135700 64343750
Cardiovascular insufficiency 16.24 12.26 10 19272 2614 64476836
Blood pressure inadequately controlled 15.77 12.26 13 19269 5371 64474079
Electrocardiogram T wave amplitude decreased 15.59 12.26 6 19276 559 64478891
Burkholderia test positive 15.45 12.26 6 19276 573 64478877
Procedural pain 15.37 12.26 21 19261 15487 64463963
White blood cell count increased 15.32 12.26 49 19233 65965 64413485
Electrocardiogram P wave abnormal 15.26 12.26 5 19277 291 64479159
Laryngeal pain 15.19 12.26 13 19269 5655 64473795
Blood triglycerides increased 14.98 12.26 23 19259 18843 64460607
Fall 14.91 12.26 69 19213 416757 64062693
Paraesthesia oral 14.89 12.26 19 19263 13112 64466338
Terminal ileitis 14.87 12.26 6 19276 634 64478816
Cytotoxic oedema 14.85 12.26 5 19277 317 64479133
Weight increased 14.49 12.26 26 19256 213322 64266128
Hiccups 14.36 12.26 15 19267 8361 64471089
Death 13.88 12.26 86 19196 482619 63996831
Respiratory failure 13.84 12.26 89 19193 161094 64318356
Pulseless electrical activity 13.77 12.26 18 19264 12721 64466729
Pulmonary oedema 13.60 12.26 53 19229 78621 64400829
Pancreatitis chronic 13.40 12.26 10 19272 3576 64475874
Stillbirth 13.29 12.26 10 19272 3623 64475827
Tumour lysis syndrome 13.10 12.26 22 19260 19418 64460032
Blood glucose increased 13.04 12.26 61 19221 98012 64381438
Lactobacillus infection 12.95 12.26 4 19278 192 64479258
Liver injury 12.90 12.26 28 19254 29904 64449546
Tetany 12.74 12.26 8 19274 2164 64477286
Hypoxia 12.59 12.26 56 19226 88093 64391357
Bilirubin conjugated increased 12.51 12.26 11 19271 4957 64474493
Toxicity to various agents 12.51 12.26 61 19221 363452 64115998
Cyanosis 12.26 12.26 23 19259 22132 64457318

FDA Adverse Event Reporting System (Pediatric)

None

Pharmacologic Action:

SourceCodeDescription
ATC A12AA03 ALIMENTARY TRACT AND METABOLISM
MINERAL SUPPLEMENTS
CALCIUM
Calcium
ATC D11AX03 DERMATOLOGICALS
OTHER DERMATOLOGICAL PREPARATIONS
OTHER DERMATOLOGICAL PREPARATIONS
Other dermatologicals
CHEBI has role CHEBI:50733 Dietary Supplement

Drug Use (View source of the data)

DiseaseRelationSNOMED_IDDOID
Hypocalcemia indication 5291005
Osteoporosis indication 64859006 DOID:11476
Hypocalcemic tetany indication 190869004
Necrotizing enterocolitis in fetus OR newborn contraindication 2707005
Alcoholism contraindication 7200002
Poisoning by digitalis glycoside contraindication 12876009
Peptic ulcer contraindication 13200003 DOID:750
Constipation contraindication 14760008 DOID:2089
Hyperphosphatemia contraindication 20165001 DOID:0050459
Hypervitaminosis D contraindication 27712000 DOID:9971
Sarcoidosis contraindication 31541009 DOID:11335
Dehydration contraindication 34095006
Hypertensive disorder contraindication 38341003 DOID:10763
Gastrointestinal ulcer contraindication 40845000
Conduction disorder of the heart contraindication 44808001
End stage renal disease contraindication 46177005 DOID:784
Humoral hypercalcemia of malignancy contraindication 47709007
Vitamin K deficiency contraindication 52675005 DOID:11249
Nasal polyp contraindication 52756005
Heart disease contraindication 56265001 DOID:114
Acute nephropathy contraindication 58574008
Hepatic failure contraindication 59927004
Hypercalcemia contraindication 66931009 DOID:12678
Hyperparathyroidism contraindication 66999008 DOID:13543
Poisoning by acetaminophen contraindication 70273001
Agoraphobia contraindication 70691001 DOID:593
Ventricular fibrillation contraindication 71908006
Hypercalciuria contraindication 71938000
Factor II deficiency contraindication 73975000
Reye's syndrome contraindication 74351001 DOID:14525
Gastrointestinal hemorrhage contraindication 74474003
Thrombotic thrombocytopenic purpura contraindication 78129009 DOID:10772
Gout contraindication 90560007 DOID:13189
Kidney disease contraindication 90708001 DOID:557
Hemophilia contraindication 90935002
Kidney stone contraindication 95570007
Anemia due to enzyme deficiency contraindication 111577008
von Willebrand disorder contraindication 128105004 DOID:12531
Seizure disorder contraindication 128613002
Obsessive-compulsive disorder contraindication 191736004 DOID:10933
Insomnia contraindication 193462001
Impaired renal function disorder contraindication 197663003
Osteolysis contraindication 203522001
Disease of liver contraindication 235856003 DOID:409
Anemia contraindication 271737000 DOID:2355
Pregnancy, function contraindication 289908002
Thrombocytopenic disorder contraindication 302215000 DOID:1588
Arteriosclerosis obliterans contraindication 361133006 DOID:5160
Panic disorder contraindication 371631005 DOID:594
Breastfeeding (mother) contraindication 413712001
Myocardial ischemia contraindication 414795007 DOID:3393
Myocardial infarction in recovery phase contraindication 418044006
Acute erosive gastritis contraindication 444926003




🐶 Veterinary Drug Use

None

🐶 Veterinary products

None

Acid dissociation constants calculated using MoKa v3.0.0

None

Orange Book patent data (new drug applications)

None

Orange Book exclusivity data (new drug applications)

None

Bioactivity Summary:

None

External reference:

IDSource
4018087 VUID
N0000146426 NUI
D00935 KEGG_DRUG
66905-23-5 SECONDARY_CAS_RN
4018087 VANDF
C0006699 UMLSCUI
CHEBI:3309 CHEBI
CHEMBL2106119 ChEMBL_ID
D002125 MESH_DESCRIPTOR_UI
DB11126 DRUGBANK_ID
SQE6VB453K UNII
9290 PUBCHEM_CID
1298846 RXNORM
20 MMSL
4337 MMSL
71865 MMSL
d03800 MMSL
000777 NDDF
007049 NDDF
387292008 SNOMEDCT_US
53691001 SNOMEDCT_US

Pharmaceutical products:

ProductCategoryIngredientsNDCFormQuantityRouteMarketingLabel
Calgonate Calcium Gluconate Gel2.5% HUMAN OTC DRUG LABEL 1 0295-7520 GEL 2.50 g TOPICAL unapproved drug other 8 sections
Calcium Gluconate HUMAN PRESCRIPTION DRUG LABEL 1 0404-9831 INJECTION, SOLUTION 98 mg INTRAVENOUS NDA 15 sections
Dairy Allergen Mix HUMAN OTC DRUG LABEL 38 43742-1277 LIQUID 6 [hp_C] ORAL unapproved drug other 9 sections
Calcium Gluconate HUMAN PRESCRIPTION DRUG LABEL 1 44567-620 INJECTION, SOLUTION 20 mg INTRAVENOUS NDA 22 sections
Calcium Gluconate HUMAN PRESCRIPTION DRUG LABEL 1 44567-621 INJECTION, SOLUTION 20 mg INTRAVENOUS NDA 22 sections
Calcium Gluconate HUMAN PRESCRIPTION DRUG LABEL 1 44567-622 INJECTION, SOLUTION 10 mg INTRAVENOUS NDA 22 sections
Calcium Gluconate Human Prescription Drug Label 1 50090-3398 INJECTION, SOLUTION 98 mg INTRAVENOUS NDA 23 sections
CALCIUM GLUCONATE HUMAN PRESCRIPTION DRUG LABEL 1 51662-1312 INJECTION, SOLUTION 98 mg INTRAVENOUS NDA 17 sections
CALCIUM GLUCONATE HUMAN PRESCRIPTION DRUG LABEL 1 51662-1347 INJECTION, SOLUTION 98 mg INTRAVENOUS NDA 17 sections
Calcium Gluconate HUMAN PRESCRIPTION DRUG LABEL 1 52584-360 INJECTION, SOLUTION 98 mg INTRAVENOUS NDA 15 sections
Calcium Gluconate HUMAN PRESCRIPTION DRUG LABEL 1 63323-360 INJECTION, SOLUTION 98 mg INTRAVENOUS NDA 23 sections
Calcium Gluconate HUMAN PRESCRIPTION DRUG LABEL 1 65219-162 INJECTION, SOLUTION 20 mg INTRAVENOUS NDA 23 sections
Calcium Gluconate HUMAN PRESCRIPTION DRUG LABEL 1 65219-164 INJECTION, SOLUTION 20 mg INTRAVENOUS NDA 23 sections
Calcium Gluconate HUMAN PRESCRIPTION DRUG LABEL 1 71872-7222 INJECTION, SOLUTION 98 mg INTRAVENOUS NDA 23 sections