zinc gluconate 🐶 Veterinary Use | Indications/Contra | FAERs-F | FAERs-M | Orange Bk | BioActivity |

Stem definition	Drug id	CAS RN
	4343	4468-02-4

Description:

Molecule	Description
Synonyms: zinc gluconate trihydrate zinc gluconate	zinc gluconate has anti-inflammatory activity; RN given refers to (D)-isomer; all RRs refers to (D)-isomer unless otherwise noted Molecular weight: 455.67 Formula: C12H22O14Zn CLOGP: LIPINSKI: None HAC: None HDO: None TPSA: 141.28 ALOGS: ROTB: None

Molecule

Description

Synonyms:

zinc gluconate trihydrate
zinc gluconate

zinc gluconate has anti-inflammatory activity; RN given refers to (D)-isomer; all RRs refers to (D)-isomer unless otherwise noted

Molecular weight: 455.67
Formula: C12H22O14Zn
CLOGP:
LIPINSKI: None
HAC: None
HDO: None
TPSA: 141.28
ALOGS:
ROTB: None

Drug dosage:

None

ADMET properties:

None

Approvals:

Date	Agency	Company	Orphan
None	FDA

FDA Adverse Event Reporting System (Female)

MedDRA adverse event term	Likelihood ratio	Likelihood ratio threshold	Patients taking drug having adverse event	Patients taking drug not having adverse event	Patients not taking drug having adverse event	Patients not taking drug not having adverse event
Sedation complication	494.80	13.81	174	18280	11498	56262115
Creatinine renal clearance decreased	457.28	13.81	174	18280	14385	56259228
Blood calcium decreased	396.92	13.81	181	18273	23588	56250025
Orthostatic hypotension	336.69	13.81	180	18274	33019	56240594
Sedation	328.47	13.81	180	18274	34674	56238939
Cognitive disorder	310.76	13.81	196	18258	48937	56224676
Depressed level of consciousness	255.62	13.81	183	18271	56250	56217363
Balance disorder	249.51	13.81	204	18250	76316	56197297
Mobility decreased	215.45	13.81	210	18244	98781	56174832
Constipation	186.89	13.81	277	18177	201666	56071947
COVID-19	106.32	13.81	127	18327	74931	56198682
Fall	89.84	13.81	289	18165	357221	55916392
Hypotension	77.46	13.81	218	18236	250290	56023323
Anosmia	62.39	13.81	30	18424	4389	56269224
Toxicity to various agents	57.58	13.81	183	18271	224381	56049232
Pain	50.89	13.81	381	18073	662803	55610810
Necrosis ischaemic	45.62	13.81	15	18439	804	56272809
Aplastic anaemia	40.45	13.81	29	18425	8899	56264714
Contraindicated product administered	38.99	13.81	7	18447	186279	56087334
Glossodynia	38.60	13.81	3	18451	152455	56121158
Beta haemolytic streptococcal infection	36.61	13.81	16	18438	1878	56271735
Rheumatoid arthritis	36.58	13.81	43	18411	382561	55891052
Systemic lupus erythematosus	35.12	13.81	8	18446	180070	56093543
Pneumonia streptococcal	35.06	13.81	15	18439	1673	56271940
Drug ineffective	34.47	13.81	170	18284	918819	55354794
Maternal exposure during pregnancy	33.95	13.81	10	18444	189543	56084070
Skin odour abnormal	32.90	13.81	14	18440	1541	56272072
Illness	32.72	13.81	48	18406	34463	56239150
Norovirus infection	30.25	13.81	9	18445	346	56273267
Pulmonary pain	30.23	13.81	16	18438	2864	56270749
Lipoedema	27.72	13.81	8	18446	276	56273337
Arthritis infective	26.19	13.81	19	18435	5937	56267676
Hidradenitis	25.92	13.81	14	18440	2610	56271003
Spinal cord disorder	25.53	13.81	11	18443	1248	56272365
Death	25.14	13.81	46	18408	341380	55932233
Acquired diaphragmatic eventration	24.58	13.81	8	18446	415	56273198
Wound secretion	22.42	13.81	15	18439	4119	56269494
White blood cell count decreased	22.25	13.81	91	18363	125899	56147714
Infrapatellar fat pad inflammation	22.03	13.81	6	18448	167	56273446
Procedural complication	22.01	13.81	16	18438	5015	56268598
Feeling abnormal	21.66	13.81	94	18360	133508	56140105
Copper deficiency	21.60	13.81	5	18449	70	56273543
Amyloid arthropathy	20.88	13.81	6	18448	204	56273409
Parosmia	20.65	13.81	15	18439	4696	56268917
Terminal insomnia	20.52	13.81	8	18446	703	56272910
Yellow skin	19.85	13.81	11	18443	2157	56271456
Drug interaction	19.56	13.81	24	18430	209731	56063882
Ageusia	19.15	13.81	22	18432	12429	56261184
Endometrial cancer	18.90	13.81	12	18442	3018	56270595
Discomfort	18.26	13.81	12	18442	141749	56131864
Product dose omission issue	18.10	13.81	122	18332	204631	56068982
Fistula discharge	17.96	13.81	8	18446	983	56272630
Haemorrhagic diathesis	17.88	13.81	13	18441	4075	56269538
Fear of falling	17.69	13.81	6	18448	354	56273259
Gastrointestinal candidiasis	17.60	13.81	5	18449	163	56273450
Heart rate variability increased	17.28	13.81	4	18450	56	56273557
Multiple drug therapy	17.27	13.81	11	18443	2781	56270832
Salpingo-oophorectomy unilateral	17.23	13.81	7	18447	685	56272928
Chondropathy	16.95	13.81	10	18444	2207	56271406
Effusion	16.87	13.81	9	18445	1637	56271976
Sneezing	16.75	13.81	23	18431	15537	56258076
Thinking abnormal	16.03	13.81	18	18436	9923	56263690
Eyelid margin crusting	15.71	13.81	7	18447	861	56272752
Urine odour abnormal	15.70	13.81	14	18440	5860	56267753
Treatment failure	15.35	13.81	20	18434	170372	56103241
Swelling	15.34	13.81	35	18419	239736	56033877
Blood smear test abnormal	15.06	13.81	4	18450	101	56273512
Wound	15.03	13.81	14	18440	138790	56134823
Dysgeusia	15.00	13.81	38	18416	40877	56232736
SARS-CoV-2 test positive	15.00	13.81	14	18440	6215	56267398
Ocular icterus	14.86	13.81	11	18443	3545	56270068
Bladder spasm	14.52	13.81	8	18446	1551	56272062
Osteoarthritis	14.17	13.81	58	18396	80238	56193375
Dysphoria	13.86	13.81	12	18442	4830	56268783

FDA Adverse Event Reporting System (Male)

MedDRA adverse event term	Likelihood ratio	Likelihood ratio threshold	Patients taking drug having adverse event	Patients taking drug not having adverse event	Patients not taking drug having adverse event	Patients not taking drug not having adverse event
Off label use	75.57	14.65	201	6527	347073	31343543
Rhinocerebral mucormycosis	56.90	14.65	14	6714	406	31690210
Anosmia	48.97	14.65	18	6710	2090	31688526
COVID-19	46.96	14.65	58	6670	54763	31635853
Fatigue	32.74	14.65	149	6579	335057	31355559
Aplastic anaemia	23.95	14.65	18	6710	9185	31681431
Product dose omission issue	21.60	14.65	60	6668	105526	31585090
Toxicity to various agents	18.02	14.65	8	6720	181479	31509137
Radiation inflammation	17.57	14.65	6	6722	562	31690054
Metal poisoning	17.27	14.65	4	6724	89	31690527
Vascular device infection	17.25	14.65	10	6718	3305	31687311
Sinusitis	16.95	14.65	29	6699	36667	31653949
Copper deficiency	16.54	14.65	3	6725	18	31690598
Pulmonary pain	15.49	14.65	6	6722	804	31689812
Muscle spasms	15.14	14.65	40	6688	68278	31622338

FDA Adverse Event Reporting System (Geriatric)

MedDRA adverse event term	Likelihood ratio	Likelihood ratio threshold	Patients taking drug having adverse event	Patients taking drug not having adverse event	Patients not taking drug having adverse event	Patients not taking drug not having adverse event
Sedation complication	508	12.75	178	20302	13232	70894732
Creatinine renal clearance decreased	464.78	12.75	178	20302	17022	70890942
Blood calcium decreased	403.94	12.75	187	20293	28659	70879305
Sedation	313.58	12.75	185	20295	46546	70861418
Cognitive disorder	304.49	12.75	200	20280	60756	70847208
Orthostatic hypotension	298.69	12.75	186	20294	51557	70856407
Mobility decreased	240.88	12.75	215	20265	102784	70805180
Balance disorder	238.73	12.75	202	20278	89926	70818038
Depressed level of consciousness	207.34	12.75	184	20296	87247	70820717
Constipation	173.50	12.75	282	20198	252156	70655808
COVID-19	130.99	12.75	157	20323	105600	70802364
Anosmia	95.26	12.75	40	20440	4843	70903121
Fall	71.46	12.75	285	20195	443811	70464153
Pain	70.86	12.75	363	20117	628453	70279511
Rhinocerebral mucormycosis	61.65	12.75	18	20462	738	70907226
Hypotension	59.07	12.75	252	20228	404129	70503835
Aplastic anaemia	53.73	12.75	42	20438	16674	70891290
Off label use	53.61	12.75	382	20098	742678	70165286
Pulmonary pain	47.02	12.75	22	20458	3440	70904524
Necrosis ischaemic	44.49	12.75	15	20465	989	70906975
Skin odour abnormal	34.74	12.75	15	20465	1944	70906020
Beta haemolytic streptococcal infection	34.68	12.75	15	20465	1952	70906012
Copper deficiency	34.63	12.75	8	20472	127	70907837
Pneumonia streptococcal	31.33	12.75	15	20465	2468	70905496
Hidradenitis	28.54	12.75	15	20465	3007	70904957
Drug ineffective	27.67	12.75	159	20321	939593	69968371
Product dose omission issue	27.51	12.75	130	20350	217338	70690626
Acquired diaphragmatic eventration	26.94	12.75	9	20471	577	70907387
Norovirus infection	26.74	12.75	8	20472	357	70907607
Toxicity to various agents	25.98	12.75	194	20286	381978	70525986
Drug interaction	24.96	12.75	45	20435	381396	70526568
Infrapatellar fat pad inflammation	22.78	12.75	6	20474	167	70907797
Arthritis infective	22.48	12.75	18	20462	7394	70900570
Lipoedema	21.74	12.75	6	20474	200	70907764
Amyloid arthropathy	21.63	12.75	6	20474	204	70907760
Ageusia	21.62	12.75	24	20456	14838	70893126
Taste disorder	21.24	12.75	21	20459	11364	70896600
Illness	21.04	12.75	35	20445	31756	70876208
SARS-CoV-2 test positive	19.96	12.75	18	20462	8683	70899281
Contraindicated product administered	19.89	12.75	7	20473	134605	70773359
Fatigue	19.88	12.75	341	20139	823978	70083986
Endometrial cancer	19.06	12.75	10	20470	1997	70905967
Terminal insomnia	18.64	12.75	8	20472	1022	70906942
Salpingo-oophorectomy unilateral	18.57	12.75	7	20473	638	70907326
Heart rate variability increased	17.72	12.75	4	20476	57	70907907
Chest discomfort	17.68	12.75	77	20403	124304	70783660
Spinal cord disorder	17.52	12.75	9	20471	1722	70906242
Systemic lupus erythematosus	17.46	12.75	4	20476	101898	70806066
Chondropathy	17.27	12.75	10	20470	2420	70905544
Multiple drug therapy	17.20	12.75	11	20469	3181	70904783
Parosmia	17.18	12.75	13	20467	4918	70903046
Maternal exposure during pregnancy	17.04	12.75	6	20474	115339	70792625
Acute kidney injury	16.93	12.75	75	20405	474549	70433415
White blood cell count decreased	16.83	12.75	95	20385	170046	70737918
Hepato-lenticular degeneration	16.79	12.75	4	20476	73	70907891
Eyelid margin crusting	16.77	12.75	7	20473	834	70907130
Opportunistic infection	16.18	12.75	10	20470	2726	70905238
Effusion	16.01	12.75	9	20471	2061	70905903
Sneezing	15.97	12.75	22	20458	16929	70891035
Nasal polyps	15.94	12.75	12	20468	4504	70903460
Cardiac failure	15.88	12.75	11	20469	143530	70764434
Feeling abnormal	15.79	12.75	82	20398	142237	70765727
Wound secretion	15.77	12.75	13	20467	5562	70902402
Radiation inflammation	15.76	12.75	6	20474	562	70907402
Fear of falling	15.64	12.75	6	20474	574	70907390
Urine odour abnormal	15.63	12.75	13	20467	5630	70902334
Rheumatoid arthritis	15.27	12.75	39	20441	291766	70616198
Coma	14.97	12.75	4	20476	91840	70816124
Intentional overdose	14.75	12.75	5	20475	98430	70809534
Scar	14.47	12.75	19	20461	13962	70894002
Rhinorrhoea	14.35	12.75	47	20433	66324	70841640
Procedural complication	14.28	12.75	14	20466	7500	70900464
Gastrointestinal candidiasis	13.98	12.75	5	20475	393	70907571
Suicide attempt	13.86	12.75	3	20477	79507	70828457
Osteoarthritis	13.84	12.75	50	20430	74097	70833867
Dysphoria	13.80	12.75	11	20469	4487	70903477
Haemorrhagic diathesis	13.55	12.75	12	20468	5655	70902309
Spleen atrophy	12.91	12.75	3	20477	49	70907915

FDA Adverse Event Reporting System (Pediatric)

None

Pharmacologic Action:

Source	Code	Description
ATC	A12CB02	ALIMENTARY TRACT AND METABOLISM MINERAL SUPPLEMENTS OTHER MINERAL SUPPLEMENTS Zinc

Drug Use | Suggest Off label Use Form| |View source of the data|

Disease	Relation	SNOMED_ID	DOID
Ascorbic acid deficiency	indication	76169001
Zinc deficiency	indication	238124008
Hereditary acrodermatitis enteropathica	off-label use	37702000
Methemoglobinemia	off-label use	38959009	DOID:10783
Viral gastroenteritis	off-label use	111843007
Cerebral trauma	off-label use	275382005
Attention deficit hyperactivity disorder	off-label use	406506008
Primary hyperoxaluria	contraindication	17901006	DOID:2977
Hypocupremia	contraindication	19577007
Multiple sclerosis	contraindication	24700007	DOID:2377
Acute tuberculosis	contraindication	25629007
Hypertensive disorder	contraindication	38341003	DOID:10763
Systemic lupus erythematosus	contraindication	55464009	DOID:9074
Allergic rhinitis	contraindication	61582004
Diarrhea	contraindication	62315008
Blood coagulation disorder	contraindication	64779008	DOID:1247
Rheumatoid arthritis	contraindication	69896004	DOID:7148
Human immunodeficiency virus infection	contraindication	86406008	DOID:526
Leukemia, disease	contraindication	93143009	DOID:1240
Anemia due to enzyme deficiency	contraindication	111577008
Hb SS disease	contraindication	127040003	DOID:10923
Hemochromatosis	contraindication	399187006	DOID:2352
Acute exacerbation of asthma	contraindication	708038006

🐶 Veterinary Drug Use

Species	Use	Relation
Dogs	Chemical sterilization	Indication

🐶 Veterinary products

Product	Applicant	Ingredients
Zeuterin	Ark Sciences Inc.	1

Acid dissociation constants calculated using MoKa v3.0.0

None

Orange Book patent data (new drug applications)

None

Orange Book exclusivity data (new drug applications)

None

Bioactivity Summary:

None

External reference:

ID	Source
4020809	VUID
N0000148330	NUI
D02390	KEGG_DRUG
12389-19-4	SECONDARY_CAS_RN
4020507	VANDF
4020809	VANDF
C0149381	UMLSCUI
CHEBI:29708	CHEBI
CHEMBL3833377	ChEMBL_ID
DB11248	DRUGBANK_ID
C030691	MESH_SUPPLEMENTAL_RECORD_UI
U6WSN5SQ1Z	UNII
443445	PUBCHEM_CID
1440975	RXNORM
5059	MMSL
5708	MMSL
72012	MMSL
d04056	MMSL
000843	NDDF
001943	NDDF
111039007	SNOMEDCT_US
420444000	SNOMEDCT_US

Pharmaceutical products:

Product	Category	Ingredients	NDC	Form	Quantity	Route	Marketing	Label
Floriva	HUMAN PRESCRIPTION DRUG LABEL	16	52796-173	TABLET, CHEWABLE	5 mg	ORAL	UNAPPROVED DRUG OTHER	6 sections
Floriva	HUMAN PRESCRIPTION DRUG LABEL	16	52796-174	TABLET, CHEWABLE	5 mg	ORAL	UNAPPROVED DRUG OTHER	6 sections
Floriva	HUMAN PRESCRIPTION DRUG LABEL	16	52796-177	TABLET, CHEWABLE	5 mg	ORAL	UNAPPROVED DRUG OTHER	7 sections
Gynetox	HUMAN OTC DRUG LABEL	21	57520-0103	LIQUID	6 [hp_X]	ORAL	unapproved homeopathic	9 sections
ZINC INJECTABLE A 1mg/ml, solution injectable pour perfusion	HUMAN PRESCRIPTION DRUG LABEL	1	60710-001	INJECTION, SOLUTION	1 mg	INTRAVENOUS	Unapproved drug for use in drug shortage	2 sections
NBB	HUMAN OTC DRUG LABEL	3	64762-862	SPRAY, METERED	12.42 mg	ORAL	OTC MONOGRAPH FINAL	12 sections
NBE	HUMAN OTC DRUG LABEL	2	64762-871	SPRAY, METERED	12.26 mg	ORAL	OTC MONOGRAPH FINAL	12 sections
Zyvana	HUMAN PRESCRIPTION DRUG LABEL	5	69336-405	CAPSULE	23 mg	ORAL	unapproved drug other	8 sections
Dermamed Nutrition for troubled skin	HUMAN OTC DRUG LABEL	7	69711-687	CAPSULE, GELATIN COATED	10 mg	ORAL	OTC monograph not final	10 sections
Detanjiang	HUMAN OTC DRUG LABEL	8	82570-008	POWDER	2 g	TOPICAL	unapproved drug other	8 sections
Detangjiang	HUMAN OTC DRUG LABEL	8	82570-018	POWDER	2 g	TOPICAL	unapproved drug other	8 sections