zinc gluconate 🐶 Veterinary Use | Indications/Contra | FAERs-F | FAERs-M | Orange Bk | BioActivity |

Stem definition	Drug id	CAS RN
	4343	4468-02-4

Description:

Molecule	Description
Synonyms: zinc gluconate trihydrate zinc gluconate	zinc gluconate has anti-inflammatory activity; RN given refers to (D)-isomer; all RRs refers to (D)-isomer unless otherwise noted Molecular weight: 455.67 Formula: C12H22O14Zn CLOGP: LIPINSKI: None HAC: None HDO: None TPSA: 141.28 ALOGS: ROTB: None

Molecule

Description

Synonyms:

zinc gluconate trihydrate
zinc gluconate

zinc gluconate has anti-inflammatory activity; RN given refers to (D)-isomer; all RRs refers to (D)-isomer unless otherwise noted

Molecular weight: 455.67
Formula: C12H22O14Zn
CLOGP:
LIPINSKI: None
HAC: None
HDO: None
TPSA: 141.28
ALOGS:
ROTB: None

Drug dosage:

None

ADMET properties:

None

Approvals:

Date	Agency	Company	Orphan
None	FDA

FDA Adverse Event Reporting System (Female)

MedDRA adverse event term	Likelihood ratio	Likelihood ratio threshold	Patients taking drug having adverse event	Patients taking drug not having adverse event	Patients not taking drug having adverse event	Patients not taking drug not having adverse event
Sedation complication	512.32	13.41	191	22558	13631	63452642
Creatinine renal clearance decreased	485.11	13.41	192	22557	16116	63450157
Blood calcium decreased	420.15	13.41	200	22549	26251	63440022
Orthostatic hypotension	358.33	13.41	199	22550	35961	63430312
Sedation	342.53	13.41	198	22551	38611	63427662
Cognitive disorder	316.45	13.41	215	22534	55600	63410673
Depressed level of consciousness	264.40	13.41	201	22548	61877	63404396
Balance disorder	263.64	13.41	228	22521	84194	63382079
Mobility decreased	219.81	13.41	243	22506	120916	63345357
Constipation	192.08	13.41	312	22437	224631	63241642
COVID-19	123.39	13.41	176	22573	112927	63353346
Fall	91.25	13.41	328	22421	392006	63074267
Hypotension	71.18	13.41	237	22512	272367	63193906
Toxicity to various agents	53.37	13.41	202	22547	247048	63219225
Contraindicated product administered	51.88	13.41	8	22741	217640	63248633
Synovitis	51.79	13.41	4	22745	186914	63279359
Pain	50.60	13.41	444	22305	740184	62726089
Pulmonary pain	48.17	13.41	24	22725	3466	63462807
Anosmia	47.53	13.41	30	22719	6830	63459443
Systemic lupus erythematosus	44.82	13.41	10	22739	208908	63257365
Necrosis ischaemic	43.59	13.41	15	22734	845	63465428
Illness	42.99	13.41	69	22680	48990	63417283
Glossodynia	41.66	13.41	7	22742	178869	63287404
Multiple drug therapy	41.44	13.41	22	22727	3624	63462649
Salpingo-oophorectomy unilateral	39.41	13.41	14	22735	867	63465406
Maternal exposure during pregnancy	39.05	13.41	15	22734	220047	63246226
Amyloid arthropathy	36.88	13.41	12	22737	568	63465705
Aplastic anaemia	36.36	13.41	29	22720	9540	63456733
Drug ineffective	34.28	13.41	227	22522	1044538	62421735
Beta haemolytic streptococcal infection	34.23	13.41	16	22733	2009	63464264
Pneumonia streptococcal	32.76	13.41	15	22734	1796	63464477
Sinusitis fungal	32.60	13.41	15	22734	1816	63464457
Product dose omission issue	31.26	13.41	166	22583	234147	63232126
Nasal polyps	31.19	13.41	22	22727	6017	63460256
Copper deficiency	30.85	13.41	7	22742	81	63466192
Skin odour abnormal	30.77	13.41	14	22735	1652	63464621
Death	29.36	13.41	56	22693	374325	63091948
Sputum increased	28.41	13.41	15	22734	2444	63463829
Dermatitis atopic	27.76	13.41	25	22724	9699	63456574
Norovirus infection	27.54	13.41	10	22739	660	63465613
Respiratory symptom	26.66	13.41	16	22733	3331	63462942
Lipoedema	26.64	13.41	8	22741	290	63465983
Wound secretion	26.64	13.41	18	22731	4596	63461677
Arthritis infective	25.40	13.41	20	22729	6458	63459815
Embolism venous	24.92	13.41	15	22734	3139	63463134
Treatment failure	24.70	13.41	21	22728	199022	63267251
Spinal cord disorder	24.40	13.41	11	22738	1270	63465003
Acquired diaphragmatic eventration	23.36	13.41	8	22741	444	63465829
White blood cell count decreased	23.14	13.41	105	22644	138999	63327274
Rhinocerebral mucormycosis	23.14	13.41	8	22741	457	63465816
Eczema	22.46	13.41	41	22708	32250	63434023
Wound	21.80	13.41	16	22733	163247	63303026
Procedural complication	21.78	13.41	17	22732	5422	63460851
Discomfort	21.58	13.41	17	22732	167357	63298916
Infrapatellar fat pad inflammation	21.50	13.41	6	22743	167	63466106
Diastolic dysfunction	21.21	13.41	18	22731	6453	63459820
Osteoarthritis	19.78	13.41	77	22672	95266	63371007
Feeling abnormal	19.68	13.41	105	22644	148287	63317986
Fistula discharge	19.61	13.41	9	22740	1084	63465189
Chest discomfort	19.03	13.41	84	22665	109885	63356388
Terminal insomnia	19.03	13.41	8	22741	781	63465492
Female genital tract fistula	18.81	13.41	18	22731	7541	63458732
Yellow skin	18.42	13.41	11	22738	2269	63464004
Emphysema	18.18	13.41	21	22728	10917	63455356
Urinary tract infection	17.57	13.41	158	22591	264526	63201747
Ageusia	17.40	13.41	23	22726	13705	63452568
Infusion site extravasation	17.30	13.41	20	22729	10406	63455867
Endometrial cancer	17.24	13.41	12	22737	3213	63463060
Heart rate variability increased	16.93	13.41	4	22745	56	63466217
Cardiac arrest	16.92	13.41	6	22743	92539	63373734
Eyelid margin crusting	16.68	13.41	8	22741	1064	63465209
Joint swelling	16.54	13.41	61	22688	327605	63138668
Gastrointestinal candidiasis	16.45	13.41	5	22744	189	63466084
Seasonal allergy	16.38	13.41	28	22721	20922	63445351
Disease recurrence	16.31	13.41	33	22716	27997	63438276
Acute kidney injury	16.11	13.41	45	22704	263370	63202903
Haemorrhagic diathesis	15.97	13.41	13	22736	4402	63461871
Parosmia	15.86	13.41	15	22734	6191	63460082
Chondropathy	15.79	13.41	10	22739	2290	63463983
Effusion	15.76	13.41	9	22740	1709	63464564
Product use in unapproved indication	15.74	13.41	114	22635	178966	63287307
Confusional state	15.50	13.41	39	22710	236341	63229932
Fear of falling	15.49	13.41	6	22743	474	63465799
Hysterectomy	15.39	13.41	18	22731	9481	63456792
Thrombocytopenia	15.29	13.41	19	22730	151138	63315135
Therapeutic product effect decreased	15.03	13.41	29	22720	193158	63273115
Intentional overdose	15.01	13.41	4	22745	74148	63392125
Candida infection	14.89	13.41	32	22717	28319	63437954
Product use issue	14.76	13.41	36	22713	220484	63245789
Blood smear test abnormal	14.70	13.41	4	22745	101	63466172
Sinus disorder	14.40	13.41	29	22720	24524	63441749
Fungal infection	14.33	13.41	37	22712	36837	63429436
Suspected transmission of an infectious agent via product	14.27	13.41	5	22744	297	63465976
Muscle injury	14.26	13.41	3	22746	65342	63400931
Sneezing	13.78	13.41	24	22725	18194	63448079
Thinking abnormal	13.75	13.41	18	22731	10625	63455648
Ocular icterus	13.72	13.41	11	22738	3645	63462628
Urine odour abnormal	13.64	13.41	14	22735	6375	63459898

FDA Adverse Event Reporting System (Male)

MedDRA adverse event term	Likelihood ratio	Likelihood ratio threshold	Patients taking drug having adverse event	Patients taking drug not having adverse event	Patients not taking drug having adverse event	Patients not taking drug not having adverse event
Off label use	77.12	14.79	245	8015	419279	34529392
Rhinocerebral mucormycosis	55.89	14.79	15	8245	553	34948118
COVID-19	54.98	14.79	79	8181	77471	34871200
Radiation inflammation	40.62	14.79	13	8247	892	34947779
Pulmonary pain	36.77	14.79	13	8247	1211	34947460
Anosmia	35.90	14.79	18	8242	4006	34944665
Product dose omission issue	31.62	14.79	80	8180	119631	34829040
Fatigue	26.18	14.79	163	8097	370490	34578181
Aplastic anaemia	21.38	14.79	18	8242	9698	34938973
Vascular device infection	18.95	14.79	12	8248	4173	34944498
Toxicity to various agents	17.61	14.79	13	8247	200349	34748322
Sinusitis	16.94	14.79	33	8227	41369	34907302
Metal poisoning	16.71	14.79	4	8256	92	34948579
Copper deficiency	15.95	14.79	3	8257	20	34948651
Arthropathy	15.61	14.79	25	8235	26882	34921789

FDA Adverse Event Reporting System (Geriatric)

MedDRA adverse event term	Likelihood ratio	Likelihood ratio threshold	Patients taking drug having adverse event	Patients taking drug not having adverse event	Patients not taking drug having adverse event	Patients not taking drug not having adverse event
Sedation complication	526.44	12.70	195	25074	15474	79703645
Creatinine renal clearance decreased	493.37	12.70	196	25073	18806	79700313
Blood calcium decreased	426.36	12.70	206	25063	31613	79687506
Sedation	324.32	12.70	203	25066	51692	79667427
Orthostatic hypotension	314.51	12.70	205	25064	55959	79663160
Cognitive disorder	305.63	12.70	219	25050	69707	79649412
Balance disorder	250.70	12.70	225	25044	98632	79620487
Mobility decreased	231.91	12.70	237	25032	121938	79597181
Depressed level of consciousness	210.26	12.70	202	25067	96450	79622669
Constipation	173.94	12.70	317	24952	282733	79436386
COVID-19	149.27	12.70	215	25054	157459	79561660
Pulmonary pain	85.14	12.70	37	25232	4436	79714683
Pain	77.52	12.70	432	24837	703370	79015749
Rhinocerebral mucormycosis	74.60	12.70	23	25246	1035	79718084
Fall	73.25	12.70	327	24942	487302	79231817
Anosmia	71.84	12.70	41	25228	8803	79710316
Hypotension	52.17	12.70	276	24993	440041	79279078
Off label use	50.20	12.70	472	24797	906743	78812376
Product dose omission issue	49.84	12.70	182	25087	247355	79471764
Aplastic anaemia	47.78	12.70	42	25227	17863	79701256
Copper deficiency	43.81	12.70	10	25259	136	79718983
Necrosis ischaemic	41.92	12.70	15	25254	1075	79718044
Salpingo-oophorectomy unilateral	41.85	12.70	14	25255	820	79718299
Multiple drug therapy	41.66	12.70	22	25247	4056	79715063
Nasal polyps	41.58	12.70	27	25242	7300	79711819
Amyloid arthropathy	38.33	12.70	12	25257	568	79718551
Illness	37.62	12.70	59	25210	46452	79672667
Radiation inflammation	36.87	12.70	13	25256	892	79718227
Synovitis	36.50	12.70	3	25266	150731	79568388
Beta haemolytic streptococcal infection	32.42	12.70	15	25254	2082	79717037
Skin odour abnormal	32.12	12.70	15	25254	2126	79716993
Sinusitis fungal	30.65	12.70	15	25254	2359	79716760
Drug ineffective	29.15	12.70	212	25057	1080701	78638418
Pneumonia streptococcal	28.59	12.70	15	25254	2730	79716389
Sputum increased	26.18	12.70	17	25252	4596	79714523
Contraindicated product administered	25.53	12.70	9	25260	157529	79561590
Acquired diaphragmatic eventration	25.10	12.70	9	25260	649	79718470
Female genital tract fistula	24.44	12.70	18	25251	5957	79713162
Acute kidney injury	24.22	12.70	84	25185	519320	79199799
Arthritis infective	23.27	12.70	20	25249	8251	79710868
Chest discomfort	23.26	12.70	96	25173	137948	79581171
Respiratory symptom	23.20	12.70	16	25253	4775	79714344
Pericarditis	22.85	12.70	3	25266	104233	79614886
Embolism venous	22.54	12.70	15	25254	4224	79714895
Infrapatellar fat pad inflammation	22.23	12.70	6	25263	167	79718952
Toxicity to various agents	21.52	12.70	216	25053	421324	79297795
Systemic lupus erythematosus	21.27	12.70	6	25263	121143	79597976
Norovirus infection	20.86	12.70	8	25261	696	79718423
Lipoedema	20.75	12.70	6	25263	216	79718903
Taste disorder	20.19	12.70	25	25244	15798	79703321
Coma	19.60	12.70	4	25265	100645	79618474
Wound secretion	19.55	12.70	16	25253	6172	79712947
Hysterectomy	19.36	12.70	16	25253	6256	79712863
Ageusia	19.20	12.70	25	25244	16607	79702512
Intentional overdose	19.07	12.70	5	25264	105955	79613164
Fistula discharge	18.73	12.70	9	25260	1359	79717760
Oral pain	18.67	12.70	35	25234	31763	79687356
Maternal exposure during pregnancy	18.64	12.70	10	25259	136528	79582591
Urinary tract infection	18.25	12.70	149	25120	274363	79444756
Disease recurrence	18.20	12.70	42	25227	44067	79675052
Drug interaction	18.11	12.70	69	25200	415114	79304005
Infusion site extravasation	18.04	12.70	19	25250	10089	79709030
Seasonal allergy	17.92	12.70	24	25245	16382	79702737
Endometrial cancer	17.79	12.70	10	25259	2084	79717035
Cardiac failure	17.53	12.70	14	25255	154828	79564291
Sinus disorder	17.47	12.70	28	25241	22436	79696683
Heart rate variability increased	17.35	12.70	4	25265	57	79719062
White blood cell count decreased	17.01	12.70	110	25159	188178	79530941
Eczema	16.99	12.70	39	25230	40779	79678340
Diastolic dysfunction	16.98	12.70	19	25250	10792	79708327
Sinusitis	16.92	12.70	113	25156	195388	79523731
Terminal insomnia	16.65	12.70	8	25261	1209	79717910
Dermatitis atopic	16.36	12.70	18	25251	10038	79709081
Treatment failure	16.27	12.70	18	25251	170468	79548651
Feeling abnormal	16.26	12.70	96	25173	159103	79560016
Spinal cord disorder	16.24	12.70	9	25260	1826	79717293
Death	16.23	12.70	109	25160	566405	79152714
Chondropathy	16.11	12.70	10	25259	2502	79716617
Fatigue	15.94	12.70	396	24873	929331	78789788
SARS-CoV-2 test positive	15.74	12.70	19	25250	11697	79707422
Emphysema	15.05	12.70	22	25247	16278	79702841
Suicide attempt	14.76	12.70	4	25265	82928	79636191
Effusion	14.67	12.70	9	25260	2205	79716914
Opportunistic infection	14.64	12.70	10	25259	2940	79716179
Eyelid margin crusting	14.60	12.70	7	25262	1052	79718067
Sneezing	14.58	12.70	24	25245	19659	79699460
Procedural complication	14.23	12.70	15	25254	7968	79711151
Osteoarthritis	14.14	12.70	60	25209	87249	79631870
Multiple allergies	14.11	12.70	17	25252	10443	79708676
Fear of falling	14.05	12.70	6	25263	689	79718430
Parosmia	13.99	12.70	14	25255	7000	79712119
Rhinorrhoea	13.68	12.70	54	25215	76020	79643099
Urine odour abnormal	13.40	12.70	13	25256	6260	79712859
Gastrointestinal candidiasis	13.11	12.70	5	25264	429	79718690
Angioedema	12.92	12.70	4	25265	76031	79643088

FDA Adverse Event Reporting System (Pediatric)

None

Pharmacologic Action:

Source	Code	Description
ATC	A12CB02	ALIMENTARY TRACT AND METABOLISM MINERAL SUPPLEMENTS OTHER MINERAL SUPPLEMENTS Zinc

Drug Use | Suggest Off label Use Form| |View source of the data|

Disease	Relation	SNOMED_ID	DOID
Ascorbic acid deficiency	indication	76169001
Zinc deficiency	indication	238124008
Hereditary acrodermatitis enteropathica	off-label use	37702000
Methemoglobinemia	off-label use	38959009	DOID:10783
Viral gastroenteritis	off-label use	111843007
Cerebral trauma	off-label use	275382005
Attention deficit hyperactivity disorder	off-label use	406506008
Primary hyperoxaluria	contraindication	17901006	DOID:2977
Hypocupremia	contraindication	19577007
Multiple sclerosis	contraindication	24700007	DOID:2377
Acute tuberculosis	contraindication	25629007
Hypertensive disorder	contraindication	38341003	DOID:10763
Systemic lupus erythematosus	contraindication	55464009	DOID:9074
Allergic rhinitis	contraindication	61582004
Diarrhea	contraindication	62315008
Blood coagulation disorder	contraindication	64779008	DOID:1247
Rheumatoid arthritis	contraindication	69896004	DOID:7148
Human immunodeficiency virus infection	contraindication	86406008	DOID:526
Leukemia, disease	contraindication	93143009	DOID:1240
Anemia due to enzyme deficiency	contraindication	111577008
Hb SS disease	contraindication	127040003	DOID:10923
Hemochromatosis	contraindication	399187006	DOID:2352
Acute exacerbation of asthma	contraindication	708038006

🐶 Veterinary Drug Use

Species	Use	Relation
Dogs	Chemical sterilization	Indication

🐶 Veterinary products

Product	Applicant	Ingredients
Zeuterin	Ark Sciences Inc.	1

Acid dissociation constants calculated using MoKa v3.0.0

None

Orange Book patent data (new drug applications)

None

Orange Book exclusivity data (new drug applications)

None

Bioactivity Summary:

None

External reference:

ID	Source
4020809	VUID
N0000148330	NUI
D02390	KEGG_DRUG
12389-19-4	SECONDARY_CAS_RN
4020507	VANDF
4020809	VANDF
C0149381	UMLSCUI
CHEBI:29708	CHEBI
CHEMBL3833377	ChEMBL_ID
DB11248	DRUGBANK_ID
C030691	MESH_SUPPLEMENTAL_RECORD_UI
U6WSN5SQ1Z	UNII
443445	PUBCHEM_CID
1440975	RXNORM
34828	MMSL
5059	MMSL
5708	MMSL
72012	MMSL
d04056	MMSL
000843	NDDF
001943	NDDF
111039007	SNOMEDCT_US
420444000	SNOMEDCT_US

Pharmaceutical products:

Product	Category	Ingredients	NDC	Form	Quantity	Route	Marketing	Label
Floriva	HUMAN PRESCRIPTION DRUG LABEL	16	52796-173	TABLET, CHEWABLE	5 mg	ORAL	UNAPPROVED DRUG OTHER	6 sections
Floriva	HUMAN PRESCRIPTION DRUG LABEL	16	52796-174	TABLET, CHEWABLE	5 mg	ORAL	UNAPPROVED DRUG OTHER	6 sections
Floriva	HUMAN PRESCRIPTION DRUG LABEL	16	52796-177	TABLET, CHEWABLE	5 mg	ORAL	UNAPPROVED DRUG OTHER	7 sections
Gynetox	HUMAN OTC DRUG LABEL	21	57520-0103	LIQUID	6 [hp_X]	ORAL	unapproved homeopathic	9 sections
ZINC INJECTABLE A 1mg/ml, solution injectable pour perfusion	HUMAN PRESCRIPTION DRUG LABEL	1	60710-001	INJECTION, SOLUTION	1 mg	INTRAVENOUS	Unapproved drug for use in drug shortage	2 sections
NBB	HUMAN OTC DRUG LABEL	3	64762-862	SPRAY, METERED	12.42 mg	ORAL	OTC MONOGRAPH FINAL	24 sections
NBE	HUMAN OTC DRUG LABEL	2	64762-871	SPRAY, METERED	12.26 mg	ORAL	OTC MONOGRAPH FINAL	12 sections
Zyvana	HUMAN PRESCRIPTION DRUG LABEL	5	69336-405	CAPSULE	23 mg	ORAL	unapproved drug other	8 sections
Dermamed Nutrition for troubled skin	HUMAN OTC DRUG LABEL	7	69711-687	CAPSULE, GELATIN COATED	10 mg	ORAL	OTC monograph not final	10 sections
Detanjiang	HUMAN OTC DRUG LABEL	8	82570-008	POWDER	2 g	TOPICAL	unapproved drug other	8 sections
Detangjiang	HUMAN OTC DRUG LABEL	8	82570-018	POWDER	2 g	TOPICAL	unapproved drug other	8 sections