zinc gluconate 🐶 Veterinary Use | Indications/Contra | FAERs-F | FAERs-M | Orange Bk | BioActivity |

Stem definitionDrug idCAS RN
4343 4468-02-4

Description:

MoleculeDescription

Synonyms:

  • zinc gluconate trihydrate
  • zinc gluconate
zinc gluconate has anti-inflammatory activity; RN given refers to (D)-isomer; all RRs refers to (D)-isomer unless otherwise noted
  • Molecular weight: 455.67
  • Formula: C12H22O14Zn
  • CLOGP:
  • LIPINSKI: None
  • HAC: None
  • HDO: None
  • TPSA: 141.28
  • ALOGS:
  • ROTB: None

Drug dosage:

None

ADMET properties:

None

Approvals:

DateAgencyCompanyOrphan
None FDA

FDA Adverse Event Reporting System (Female)

MedDRA adverse event termLikelihood ratioLikelihood ratio thresholdPatients taking drug having adverse eventPatients taking drug not having adverse eventPatients not taking drug having adverse eventPatients not taking drug not having adverse event
Sedation complication 357.50 13.94 124 14987 8642 50581371
Creatinine renal clearance decreased 324.29 13.94 125 14986 11756 50578257
Blood calcium decreased 275.70 13.94 131 14980 20575 50569438
Orthostatic hypotension 232.01 13.94 131 14980 29350 50560663
Sedation 216.80 13.94 127 14984 30483 50559530
Cognitive disorder 214.11 13.94 144 14967 43979 50546034
Depressed level of consciousness 170.90 13.94 134 14977 51819 50538194
Mobility decreased 168.88 13.94 160 14951 79788 50510225
Balance disorder 167.96 13.94 151 14960 70439 50519574
Constipation 142.32 13.94 222 14889 185486 50404527
Anosmia 65.20 13.94 29 15082 3902 50586111
Fall 53.13 13.94 219 14892 334713 50255300
COVID-19 52.24 13.94 67 15044 46595 50543418
Necrosis ischaemic 47.36 13.94 15 15096 784 50589229
Hypotension 45.50 13.94 164 14947 235305 50354708
Pain 39.35 13.94 301 14810 578602 50011411
Beta haemolytic streptococcal infection 38.59 13.94 16 15095 1814 50588199
Aplastic anaemia 36.97 13.94 25 15086 7678 50582335
Pneumonia streptococcal 36.91 13.94 15 15096 1616 50588397
Contraindicated product administered 33.45 13.94 3 15108 148955 50441058
Drug ineffective 31.63 13.94 132 14979 819201 49770812
Skin odour abnormal 31.48 13.94 13 15098 1459 50588554
Norovirus infection 29.54 13.94 8 15103 240 50589773
Maternal exposure during pregnancy 29.33 13.94 6 15105 159772 50430241
Lipoedema 28.77 13.94 8 15103 265 50589748
Illness 27.08 13.94 35 15076 24505 50565508
Spinal cord disorder 26.97 13.94 11 15100 1196 50588817
Toxicity to various agents 26.12 13.94 129 14982 212370 50377643
Acquired diaphragmatic eventration 25.54 13.94 8 15103 403 50589610
Drug interaction 25.40 13.94 14 15097 199607 50390406
Glossodynia 24.22 13.94 3 15108 115566 50474447
Infrapatellar fat pad inflammation 22.79 13.94 6 15105 161 50589852
Death 22.67 13.94 39 15072 325340 50264673
Wound secretion 22.26 13.94 14 15097 3803 50586210
Ageusia 22.17 13.94 22 15089 11561 50578452
Arthritis infective 21.89 13.94 16 15095 5553 50584460
Terminal insomnia 21.72 13.94 8 15103 661 50589352
Procedural complication 21.60 13.94 15 15096 4808 50585205
Yellow skin 21.50 13.94 11 15100 2018 50587995
Systemic lupus erythematosus 20.77 13.94 8 15103 140614 50449399
Endometrial cancer 20.48 13.94 12 15099 2871 50587142
Osteoarthritis 19.84 13.94 55 15056 68551 50521462
Haemorrhagic diathesis 19.39 13.94 13 15098 3935 50586078
Fistula discharge 19.08 13.94 8 15103 932 50589081
Chondropathy 18.32 13.94 10 15101 2090 50587923
Parosmia 18.02 13.94 13 15098 4423 50585590
Thinking abnormal 18.00 13.94 18 15093 9549 50580464
Effusion 17.89 13.94 9 15102 1594 50588419
Copper deficiency 17.52 13.94 4 15107 58 50589955
Sneezing 17.03 13.94 21 15090 14023 50575990
Feeling abnormal 16.71 13.94 78 15033 125414 50464599
Discomfort 16.27 13.94 6 15105 108374 50481639
Ocular icterus 16.01 13.94 11 15100 3464 50586549
Bladder spasm 15.87 13.94 8 15103 1422 50588591
White blood cell count decreased 15.87 13.94 73 15038 116649 50473364
Urine odour abnormal 15.81 13.94 13 15098 5360 50584653
Blood smear test abnormal 15.58 13.94 4 15107 97 50589916
Dysphoria 14.99 13.94 12 15099 4762 50585251
Pulmonary pain 14.79 13.94 9 15102 2306 50587707
Abnormal faeces 14.15 13.94 11 15100 4185 50585828
Eyelid margin crusting 14.13 13.94 6 15105 722 50589291

FDA Adverse Event Reporting System (Male)

MedDRA adverse event termLikelihood ratioLikelihood ratio thresholdPatients taking drug having adverse eventPatients taking drug not having adverse eventPatients not taking drug having adverse eventPatients not taking drug not having adverse event
Off label use 72.60 15.78 174 5714 300626 29268013
Anosmia 47.32 15.78 17 5871 1974 29566665
Rhinocerebral mucormycosis 32.66 15.78 8 5880 243 29568396
Fatigue 28.22 15.78 131 5757 316690 29251949
COVID-19 24.61 15.78 33 5855 35981 29532658
Aplastic anaemia 23.44 15.78 16 5872 7494 29561145
Metal poisoning 17.70 15.78 4 5884 85 29568554

FDA Adverse Event Reporting System (Geriatric)

MedDRA adverse event termLikelihood ratioLikelihood ratio thresholdPatients taking drug having adverse eventPatients taking drug not having adverse eventPatients not taking drug having adverse eventPatients not taking drug not having adverse event
Sedation complication 368.80 13.01 128 16730 10226 64471648
Creatinine renal clearance decreased 330.99 13.01 129 16729 14292 64467582
Blood calcium decreased 284.06 13.01 137 16721 25417 64456457
Cognitive disorder 211.79 13.01 148 16710 54939 64426935
Sedation 211.76 13.01 133 16725 41329 64440545
Orthostatic hypotension 206.84 13.01 137 16721 46601 64435273
Mobility decreased 185.26 13.01 164 16694 85676 64396198
Balance disorder 156.96 13.01 148 16710 83778 64398096
Depressed level of consciousness 136.05 13.01 135 16723 81301 64400573
Constipation 129.39 13.01 222 16636 229115 64252759
Anosmia 99.47 13.01 39 16819 4378 64477496
COVID-19 68.84 13.01 85 16773 65055 64416819
Pain 54.88 13.01 287 16571 553224 63928650
Off label use 52.06 13.01 312 16546 632494 63849380
Aplastic anaemia 50.18 13.01 36 16822 13884 64467990
Necrosis ischaemic 46.27 13.01 15 16843 968 64480906
Fall 38.40 13.01 212 16646 416614 64065260
Beta haemolytic streptococcal infection 36.67 13.01 15 16843 1879 64479995
Hypotension 35.90 13.01 195 16663 380779 64101095
Drug interaction 33.91 13.01 27 16831 362056 64119818
Skin odour abnormal 33.49 13.01 14 16844 1853 64480021
Pneumonia streptococcal 33.38 13.01 15 16843 2363 64479511
Norovirus infection 30.99 13.01 8 16850 228 64481646
Rhinocerebral mucormycosis 29.42 13.01 9 16849 480 64481394
Acquired diaphragmatic eventration 28.02 13.01 9 16849 564 64481310
Copper deficiency 25.91 13.01 6 16852 107 64481767
Ageusia 25.09 13.01 24 16834 13789 64468085
Infrapatellar fat pad inflammation 23.59 13.01 6 16852 161 64481713
Drug ineffective 23.32 13.01 127 16731 840120 63641754
Lipoedema 22.57 13.01 6 16852 192 64481682
Endometrial cancer 20.48 13.01 10 16848 1900 64479974
Terminal insomnia 19.92 13.01 8 16850 956 64480918
Fatigue 19.63 13.01 289 16569 748441 63733433
Spinal cord disorder 18.90 13.01 9 16849 1617 64480257
Osteoarthritis 18.63 13.01 47 16811 63289 64418585
Chondropathy 18.52 13.01 10 16848 2339 64479535
Contraindicated product administered 18.48 13.01 3 16855 107826 64374048
Arthritis infective 18.34 13.01 15 16843 7015 64474859
SARS-CoV-2 test positive 17.64 13.01 14 16844 6272 64475602
Pulmonary pain 17.63 13.01 10 16848 2574 64479300
Opportunistic infection 17.35 13.01 10 16848 2652 64479222
Effusion 17.28 13.01 9 16849 1959 64479915
Product dose omission issue 16.51 13.01 97 16761 194650 64287224
Chest discomfort 16.45 13.01 67 16791 116039 64365835
Maternal exposure during pregnancy 15.71 13.01 3 16855 95881 64385993
Urine odour abnormal 15.63 13.01 12 16846 5124 64476750
Wound secretion 15.43 13.01 12 16846 5220 64476654
Dysphoria 15.02 13.01 11 16847 4377 64477497
Eyelid margin crusting 14.98 13.01 6 16852 712 64481162
Scar 14.98 13.01 18 16840 13380 64468494
Haemorrhagic diathesis 14.88 13.01 12 16846 5502 64476372
Illness 14.69 13.01 23 16835 21915 64459959
Sneezing 14.66 13.01 19 16839 15232 64466642
Taste disorder 14.56 13.01 15 16843 9418 64472456
Nasal polyps 14.51 13.01 10 16848 3619 64478255
Parosmia 14.47 13.01 11 16847 4629 64477245
Procedural complication 13.91 13.01 13 16845 7252 64474622
Cardiac failure 13.50 13.01 9 16849 132364 64349510
Salpingo-oophorectomy unilateral 13.39 13.01 5 16853 491 64481383
Death 13.31 13.01 73 16785 482632 63999242
Rhinorrhoea 13.17 13.01 40 16818 59929 64421945
Hepato-lenticular degeneration 13.15 13.01 3 16855 50 64481824
Fistula discharge 13.06 13.01 6 16852 994 64480880

FDA Adverse Event Reporting System (Pediatric)

None

Pharmacologic Action:

SourceCodeDescription
ATC A12CB02 ALIMENTARY TRACT AND METABOLISM
MINERAL SUPPLEMENTS
OTHER MINERAL SUPPLEMENTS
Zinc

Drug Use (View source of the data)

DiseaseRelationSNOMED_IDDOID
Ascorbic acid deficiency indication 76169001
Zinc deficiency indication 238124008
Hereditary acrodermatitis enteropathica off-label use 37702000
Methemoglobinemia off-label use 38959009 DOID:10783
Viral gastroenteritis off-label use 111843007
Cerebral trauma off-label use 275382005
Attention deficit hyperactivity disorder off-label use 406506008
Primary hyperoxaluria contraindication 17901006 DOID:2977
Hypocupremia contraindication 19577007
Multiple sclerosis contraindication 24700007 DOID:2377
Acute tuberculosis contraindication 25629007
Hypertensive disorder contraindication 38341003 DOID:10763
Systemic lupus erythematosus contraindication 55464009 DOID:9074
Allergic rhinitis contraindication 61582004
Diarrhea contraindication 62315008
Blood coagulation disorder contraindication 64779008 DOID:1247
Rheumatoid arthritis contraindication 69896004 DOID:7148
Human immunodeficiency virus infection contraindication 86406008 DOID:526
Leukemia, disease contraindication 93143009 DOID:1240
Anemia due to enzyme deficiency contraindication 111577008
Hb SS disease contraindication 127040003 DOID:10923
Hemochromatosis contraindication 399187006 DOID:2352
Acute exacerbation of asthma contraindication 708038006




🐶 Veterinary Drug Use

None

🐶 Veterinary products

ProductApplicantIngredients
Zeuterin Ark Sciences Inc. 1

Acid dissociation constants calculated using MoKa v3.0.0

None

Orange Book patent data (new drug applications)

None

Orange Book exclusivity data (new drug applications)

None

Bioactivity Summary:

None

External reference:

IDSource
4020809 VUID
N0000148330 NUI
D02390 KEGG_DRUG
12389-19-4 SECONDARY_CAS_RN
4020507 VANDF
4020809 VANDF
C0149381 UMLSCUI
CHEBI:29708 CHEBI
CHEMBL3833377 ChEMBL_ID
DB11248 DRUGBANK_ID
C030691 MESH_SUPPLEMENTAL_RECORD_UI
U6WSN5SQ1Z UNII
20543 PUBCHEM_CID
1440975 RXNORM
5059 MMSL
5708 MMSL
72012 MMSL
d04056 MMSL
000843 NDDF
001943 NDDF
111039007 SNOMEDCT_US
420444000 SNOMEDCT_US

Pharmaceutical products:

ProductCategoryIngredientsNDCFormQuantityRouteMarketingLabel
Floriva HUMAN PRESCRIPTION DRUG LABEL 16 52796-173 TABLET, CHEWABLE 5 mg ORAL UNAPPROVED DRUG OTHER 6 sections
Floriva HUMAN PRESCRIPTION DRUG LABEL 16 52796-174 TABLET, CHEWABLE 5 mg ORAL UNAPPROVED DRUG OTHER 6 sections
Floriva HUMAN PRESCRIPTION DRUG LABEL 16 52796-177 TABLET, CHEWABLE 5 mg ORAL UNAPPROVED DRUG OTHER 7 sections
Gynetox HUMAN OTC DRUG LABEL 21 57520-0103 LIQUID 6 [hp_X] ORAL unapproved homeopathic 9 sections
ZINC INJECTABLE A 1mg/ml, solution injectable pour perfusion HUMAN PRESCRIPTION DRUG LABEL 1 60710-001 INJECTION, SOLUTION 1 mg INTRAVENOUS Unapproved drug for use in drug shortage 2 sections
NBB HUMAN OTC DRUG LABEL 3 64762-862 SPRAY, METERED 12.42 mg ORAL OTC MONOGRAPH FINAL 12 sections
NBE HUMAN OTC DRUG LABEL 2 64762-871 SPRAY, METERED 12.26 mg ORAL OTC MONOGRAPH FINAL 12 sections
Zyvana HUMAN PRESCRIPTION DRUG LABEL 5 69336-405 CAPSULE 23 mg ORAL unapproved drug other 8 sections
Dermamed Nutrition for troubled skin HUMAN OTC DRUG LABEL 7 69711-687 CAPSULE, GELATIN COATED 10 mg ORAL OTC monograph not final 10 sections
Detanjiang HUMAN OTC DRUG LABEL 8 82570-008 POWDER 2 g TOPICAL unapproved drug other 8 sections
Detangjiang HUMAN OTC DRUG LABEL 8 82570-018 POWDER 2 g TOPICAL unapproved drug other 8 sections