angiotensinamide 🐶 Veterinary Use | Indications/Contra | FAERs-F | FAERs-M | Orange Bk | PK/Tox | Related Drugs | BioActivity |

Stem definitionDrug idCAS RN
peptides and glycopeptides 4338 38027-96-2

Description:

MoleculeDescription

Molfile Inchi Smiles

Synonyms:

  • angiotensinamide
  • Molecular weight: 1031.19
  • Formula: C49H70N14O11
  • CLOGP: -5.05
  • LIPINSKI: 3
  • HAC: 25
  • HDO: 14
  • TPSA: 412.13
  • ALOGS: -4.79
  • ROTB: 28

Drug dosage:

DoseUnitRoute
5 mg P

ADMET properties:

None

Predicted pharmacokinetic/toxicological properties (PK-AZ):

PropertyDescriptionValueUnitConfidenceSimilarity
azlogd74 LogD at pH 7.4 -0.903 Moderate 0.77
caco2-efflux Caco-2 efflux ratio (BA/AB) 1.824 Moderate 0.77
caco2-intrinsic-papp Caco-2 intrinsic apparent permeability 0.352 10^-6 cm/s Moderate 0.77
dh-clint Dog hepatocyte intrinsic clearance 1.611 uL/min/10^6 cells Moderate 0.77
dppb Dog plasma protein binding (% unbound) 64.800 % Moderate 0.77
fcs-ppb Fetal calf serum protein binding (% unbound) 35.360 % Moderate 0.77
herg hERG pIC50 4.646 pIC50 Moderate 0.77
hh-clint Human hepatocyte intrinsic clearance 95.499 uL/min/10^6 cells Moderate 0.77
hlm-clint Human liver microsomal intrinsic clearance 12.417 uL/min/mg protein Moderate 0.77
hppb Human plasma protein binding (% unbound) 56.130 % Moderate 0.77
kinase-safety-class ACVR2B,AXL,BRAF,BTK,CAMK2D,CDK5,CDK9,EIF2AK3,ERBB2,GRK2,ITK,MAPK7,NTRK2,PDK1,PDK2,PDK4,PRKDC,TEK,TGFBR1 19
kinase-selectivity-class GRK2,PDK1 2
mdck-mdr1-efflux MDCK-MDR1 efflux ratio 2.023 Moderate 0.77
mh-clint Mouse hepatocyte intrinsic clearance 78.343 Moderate 0.77
mppb Mouse plasma protein binding (% unbound) 45.180 Moderate 0.77
nih-mdck-mdr1-efflux NIH MDCK-MDR1 efflux ratio 1.675 Moderate 0.77
pfas-class PFAS structural alert (1 = True, 0 = False) 0
pppb Pig plasma protein binding (% unbound) 41.950 % Moderate 0.77
rh-clint Rat hepatocyte intrinsic clearance 79.983 uL/min/10^6 cells Moderate 0.77
rh-fuinc Rat hepatocyte fraction unbound in incubation 35.460 % Moderate 0.77
rppb Rat plasma protein binding (% unbound) 43.080 % Moderate 0.77
solubility-dd Solubility at pH 7.4 in DMSO 174.582 uM Moderate 0.77

Approvals:

None

FDA Adverse Event Reporting System (Female)

None

FDA Adverse Event Reporting System (Male)

None

FDA Adverse Event Reporting System (Geriatric)

None

FDA Adverse Event Reporting System (Pediatric)

None

Pharmacologic Action:

SourceCodeDescription
ATC C01CX06 CARDIOVASCULAR SYSTEM
CARDIAC THERAPY
CARDIAC STIMULANTS EXCL. CARDIAC GLYCOSIDES
Other cardiac stimulants
MeSH PA D002317 Cardiovascular Agents
MeSH PA D014662 Vasoconstrictor Agents
CHEBI has role CHEBI:35554 cardiovascular drug

Related Drugs by ATC class:

C01CX Other cardiac stimulants 3 drugs
angiotensin IIlevosimendanxamoterol

Drug Use | Suggest Off label Use Form| |View source of the data|

DiseaseRelationSNOMED_IDDOID
Low blood pressure indication 45007003




🐶 Veterinary Drug Use

None

🐶 Veterinary products

None

Acid dissociation constants calculated using MoKa v3.0.0

Dissociation levelDissociation constantType (acidic/basic)
pKa1 3.61 acidic
pKa2 9.65 acidic
pKa3 12.46 acidic
pKa4 13.07 acidic
pKa5 13.77 acidic
pKa6 10.75 Basic
pKa7 7.31 Basic
pKa8 6.3 Basic

Orange Book patent data (new drug applications)

None

Orange Book exclusivity data (new drug applications)

None

Bioactivity Summary:

None

External reference:

IDSource
53-73-6 SECONDARY_CAS_RN
C0003001 UMLSCUI
CHEBI:748275 CHEBI
CHEMBL409803 ChEMBL_ID
DB13517 DRUGBANK_ID
1057 INN_ID
7WAL1X78KV UNII
10351092 PUBCHEM_CID
D000802 MESH_DESCRIPTOR_UI

Pharmaceutical products:

None