Stem definition | Drug id | CAS RN |
---|---|---|
cardiac stimulants, pimobendan derivatives | 1576 | 141505-33-1 |
Dose | Unit | Route |
---|---|---|
11 | mg | P |
Property | Value | Reference |
---|---|---|
BA (Bioavailability) | 85 % | Kim MT, Sedykh A, Chakravarti SK, Saiakhov RD, Zhu H |
Vd (Volume of distribution) | 0.24 L/kg | Lombardo F, Berellini G, Obach RS |
CL (Clearance) | 3.80 mL/min/kg | Lombardo F, Berellini G, Obach RS |
fu (Fraction unbound in plasma) | 0.02 % | Lombardo F, Berellini G, Obach RS |
t_half (Half-life) | 1.10 hours | Lombardo F, Berellini G, Obach RS |
None
MedDRA adverse event term | Likelihood ratio | Likelihood ratio threshold | Patients taking drug having adverse event | Patients taking drug not having adverse event | Patients not taking drug having adverse event | Patients not taking drug not having adverse event |
---|---|---|---|---|---|---|
Lymphatic fistula | 130.61 | 96.07 | 22 | 1521 | 764 | 56289760 |
Femoral hernia incarcerated | 130.19 | 96.07 | 22 | 1521 | 779 | 56289745 |
Pancreatic steatosis | 126.03 | 96.07 | 22 | 1521 | 946 | 56289578 |
Arterial haemorrhage | 120.89 | 96.07 | 23 | 1520 | 1602 | 56288922 |
Wound infection pseudomonas | 119.30 | 96.07 | 22 | 1521 | 1293 | 56289231 |
Seroma | 111.10 | 96.07 | 22 | 1521 | 1889 | 56288635 |
Haemarthrosis | 106.50 | 96.07 | 23 | 1520 | 3021 | 56287503 |
Aortic valve stenosis | 105.73 | 96.07 | 23 | 1520 | 3124 | 56287400 |
Cardiogenic shock | 105.41 | 96.07 | 32 | 1511 | 16293 | 56274231 |
Tachyarrhythmia | 99.01 | 96.07 | 23 | 1520 | 4198 | 56286326 |
None
MedDRA adverse event term | Likelihood ratio | Likelihood ratio threshold | Patients taking drug having adverse event | Patients taking drug not having adverse event | Patients not taking drug having adverse event | Patients not taking drug not having adverse event |
---|---|---|---|---|---|---|
Lymphatic fistula | 130.50 | 76.54 | 22 | 1895 | 778 | 70925749 |
Femoral hernia incarcerated | 130.31 | 76.54 | 22 | 1895 | 785 | 70925742 |
Pancreatic steatosis | 124.32 | 76.54 | 22 | 1895 | 1038 | 70925489 |
Wound infection pseudomonas | 115.49 | 76.54 | 22 | 1895 | 1562 | 70924965 |
Arterial haemorrhage | 112.13 | 76.54 | 23 | 1894 | 2388 | 70924139 |
Seroma | 108.95 | 76.54 | 22 | 1895 | 2112 | 70924415 |
Cardiogenic shock | 98.63 | 76.54 | 37 | 1880 | 36270 | 70890257 |
Aortic valve stenosis | 95.61 | 76.54 | 23 | 1894 | 4936 | 70921591 |
Haemarthrosis | 93.50 | 76.54 | 23 | 1894 | 5416 | 70921111 |
Tachyarrhythmia | 89.85 | 76.54 | 23 | 1894 | 6359 | 70920168 |
Hepatic cyst | 87.93 | 76.54 | 22 | 1895 | 5549 | 70920978 |
Wound dehiscence | 85.57 | 76.54 | 22 | 1895 | 6186 | 70920341 |
Diverticulum intestinal | 84.58 | 76.54 | 23 | 1894 | 8018 | 70918509 |
Inflammatory marker increased | 81.33 | 76.54 | 23 | 1894 | 9251 | 70917276 |
Aortic arteriosclerosis | 80.40 | 76.54 | 22 | 1895 | 7847 | 70918680 |
Eructation | 80.17 | 76.54 | 23 | 1894 | 9737 | 70916790 |
None
Source | Code | Description |
---|---|---|
ATC | C01CX08 | CARDIOVASCULAR SYSTEM CARDIAC THERAPY CARDIAC STIMULANTS EXCL. CARDIAC GLYCOSIDES Other cardiac stimulants |
MeSH PA | D002316 | Cardiotonic Agents |
MeSH PA | D002317 | Cardiovascular Agents |
MeSH PA | D004791 | Enzyme Inhibitors |
MeSH PA | D058987 | Phosphodiesterase 3 Inhibitors |
MeSH PA | D010726 | Phosphodiesterase Inhibitors |
MeSH PA | D020011 | Protective Agents |
MeSH PA | D014665 | Vasodilator Agents |
CHEBI has role | CHEBI:35620 | vasodilator agents |
CHEBI has role | CHEBI:38070 | antiarrhythmic agent |
CHEBI has role | CHEBI:38147 | cardiotonic drugs |
CHEBI has role | CHEBI:50568 | 3,5-cyclic nucleoside monophosphate phosphodiesterase inhibitors |
Disease | Relation | SNOMED_ID | DOID |
---|---|---|---|
Congestive heart failure | indication | 42343007 | DOID:6000 |
None
None
Dissociation level | Dissociation constant | Type (acidic/basic) |
---|---|---|
pKa1 | 6.04 | acidic |
pKa2 | 11.34 | acidic |
pKa3 | 4.67 | Basic |
pKa4 | 4.04 | Basic |
None
None
Target | Class | Pharos | UniProt | Action | Type | Activity value (-log[M]) | Mechanism action | Bioact source | MoA source |
---|---|---|---|---|---|---|---|---|---|
Troponin C, slow skeletal and cardiac muscles | Cytosolic other | OPENER | Kd | 3.16 | SCIENTIFIC LITERATURE | SCIENTIFIC LITERATURE | |||
ATP-sensitive inward rectifier potassium channel 11 | Ion channel | WOMBAT-PK | |||||||
ATP-sensitive inward rectifier potassium channel 8 | Ion channel | WOMBAT-PK | |||||||
cGMP-inhibited 3',5'-cyclic phosphodiesterase A | Enzyme | WOMBAT-PK |
ID | Source |
---|---|
D04720 | KEGG_DRUG |
C0246904 | UMLSCUI |
CHEBI:50567 | CHEBI |
CHEMBL2051955 | ChEMBL_ID |
DB00922 | DRUGBANK_ID |
D000077464 | MESH_DESCRIPTOR_UI |
3033825 | PUBCHEM_CID |
7020 | INN_ID |
C6T4514L4E | UNII |
73107 | RXNORM |
009718 | NDDF |
442790008 | SNOMEDCT_US |
442795003 | SNOMEDCT_US |
None