Stem definition | Drug id | CAS RN |
---|---|---|
cardiac stimulants, pimobendan derivatives | 1576 | 141505-33-1 |
Dose | Unit | Route |
---|---|---|
11 | mg | P |
Property | Value | Reference |
---|---|---|
BA (Bioavailability) | 85 % | Kim MT, Sedykh A, Chakravarti SK, Saiakhov RD, Zhu H |
Vd (Volume of distribution) | 0.24 L/kg | Lombardo F, Berellini G, Obach RS |
CL (Clearance) | 3.80 mL/min/kg | Lombardo F, Berellini G, Obach RS |
fu (Fraction unbound in plasma) | 0.02 % | Lombardo F, Berellini G, Obach RS |
t_half (Half-life) | 1.10 hours | Lombardo F, Berellini G, Obach RS |
None
MedDRA adverse event term | Likelihood ratio | Likelihood ratio threshold | Patients taking drug having adverse event | Patients taking drug not having adverse event | Patients not taking drug having adverse event | Patients not taking drug not having adverse event |
---|---|---|---|---|---|---|
Lymphatic fistula | 120.98 | 89.97 | 21 | 1436 | 877 | 53346732 |
Femoral hernia incarcerated | 120.66 | 89.97 | 21 | 1436 | 891 | 53346718 |
Pancreatic steatosis | 116.74 | 89.97 | 21 | 1436 | 1078 | 53346531 |
Arterial haemorrhage | 112.79 | 89.97 | 22 | 1435 | 1754 | 53345855 |
Wound infection pseudomonas | 110.69 | 89.97 | 21 | 1436 | 1446 | 53346163 |
Cardiogenic shock | 103.38 | 89.97 | 32 | 1425 | 17450 | 53330159 |
Seroma | 102.54 | 89.97 | 21 | 1436 | 2144 | 53345465 |
Haemarthrosis | 99.40 | 89.97 | 22 | 1435 | 3248 | 53344361 |
Aortic valve stenosis | 99.28 | 89.97 | 22 | 1435 | 3266 | 53344343 |
Tachyarrhythmia | 91.39 | 89.97 | 22 | 1435 | 4694 | 53342915 |
MedDRA adverse event term | Likelihood ratio | Likelihood ratio threshold | Patients taking drug having adverse event | Patients taking drug not having adverse event | Patients not taking drug having adverse event | Patients not taking drug not having adverse event |
---|
Source | Code | Description |
---|---|---|
ATC | C01CX08 | CARDIOVASCULAR SYSTEM CARDIAC THERAPY CARDIAC STIMULANTS EXCL. CARDIAC GLYCOSIDES Other cardiac stimulants |
MeSH PA | D002316 | Cardiotonic Agents |
MeSH PA | D002317 | Cardiovascular Agents |
MeSH PA | D004791 | Enzyme Inhibitors |
MeSH PA | D058987 | Phosphodiesterase 3 Inhibitors |
MeSH PA | D010726 | Phosphodiesterase Inhibitors |
MeSH PA | D020011 | Protective Agents |
MeSH PA | D014665 | Vasodilator Agents |
CHEBI has role | CHEBI:35620 | vasodilator |
CHEBI has role | CHEBI:38070 | antiarrhythmic agent |
CHEBI has role | CHEBI:38147 | cardiotonic drugs |
CHEBI has role | CHEBI:50568 | cyclic nucleotide phosphodiesterase inhibitor |
Disease | Relation | SNOMED_ID | DOID |
---|---|---|---|
Congestive heart failure | indication | 42343007 | DOID:6000 |
Dissociation level | Dissociation constant | Type (acidic/basic) |
---|---|---|
pKa1 | 6.04 | acidic |
pKa2 | 11.34 | acidic |
pKa3 | 4.67 | Basic |
pKa4 | 4.04 | Basic |
None
None
Target | Class | Pharos | UniProt | Action | Type | Activity value (-log[M]) | Mechanism action | Bioact source | MoA source |
---|---|---|---|---|---|---|---|---|---|
Troponin C, slow skeletal and cardiac muscles | Cytosolic other | OPENER | Kd | 3.16 | SCIENTIFIC LITERATURE | SCIENTIFIC LITERATURE | |||
cGMP-inhibited 3',5'-cyclic phosphodiesterase A | Enzyme | WOMBAT-PK | |||||||
ATP-sensitive inward rectifier potassium channel 11 | Ion channel | WOMBAT-PK | |||||||
ATP-sensitive inward rectifier potassium channel 8 | Ion channel | WOMBAT-PK |
ID | Source |
---|---|
D04720 | KEGG_DRUG |
C0246904 | UMLSCUI |
CHEBI:50567 | CHEBI |
CHEMBL2051955 | ChEMBL_ID |
DB00922 | DRUGBANK_ID |
D000077464 | MESH_DESCRIPTOR_UI |
3033825 | PUBCHEM_CID |
7020 | INN_ID |
C6T4514L4E | UNII |
73107 | RXNORM |
009718 | NDDF |
442790008 | SNOMEDCT_US |
442795003 | SNOMEDCT_US |
None